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Conserved domains on  [gi|1907132195|ref|XP_036017434|]
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echinoderm microtubule-associated protein-like 3 isoform X2 [Mus musculus]

Protein Classification

HELP and WD40 domain-containing protein( domain architecture ID 12044477)

HELP and WD40 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HELP pfam03451
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm ...
 189-257 2.96e-32

HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.


:

Pssm-ID: 460922  Cd Length: 72  Bit Score: 119.58  E-value: 2.96e-32
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907132195 189 KMFLRGRPITMYIPSGIRSLEELPS--GPPPETLSLDWVYGYRGRDSRSNLFVLRSGEVVYFIACVVVLYR 257
Cdd:pfam03451   1 KMAIRGRPGAVYPPSNYYPKDDLDQkkEPPDKKLKLEWVYGYRGKDCRSNLYYLPTGEIVYFTAAVVVLYD 71
WD40 COG2319
WD40 repeat [General function prediction only];
477-841 3.43e-28

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 118.09  E-value: 3.43e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132195 477 TIVAQAHAHEGSIFALCLRRDGTVLSGGGRDRRLVQWGPgLVALQEAEIPEHFGAVRAIA-EGLGSELLVGTTKNALLRG 555
Cdd:COG2319    69 ALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDL-ATGLLLRTLTGHTGAVRSVAfSPDGKTLASGSADGTVRLW 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132195 556 DLAQG-FSPVIQGHTDELWGLCTHPSQNRFLTCGHDRQLCLWDGEGHALAWSMDLKETGL-CADFHPSGAVVVVGLNTGR 633
Cdd:COG2319   148 DLATGkLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVrSVAFSPDGKLLASGSADGT 227

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132195 634 WLVLDTETREIVSDVTDGNEQLSVVRYSPDGLYLAIGSHDNMIYIYSVSScGTKSSRFGrcmGHSSFITHLDWSKDGNFI 713
Cdd:COG2319   228 VRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLAT-GELLRTLT---GHSGGVNSVAFSPDGKLL 303

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132195 714 MSNSGDYEILYWDVAGGcKLLRnryesrdrewatytcVLGFHVYGVWpdgsdgtdinSLCRSHNERVVAVADDFCKVHLF 793
Cdd:COG2319   304 ASGSDDGTVRLWDLATG-KLLR---------------TLTGHTGAVR----------SVAFSPDGKTLASGSDDGTVRLW 357

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 1907132195 794 QypcARAKAPSRMYSGHGSHVTSVRFTHDDSYLVSlGGKDASIFQWRV 841
Cdd:COG2319   358 D---LATGELLRTLTGHTGAVTSVAFSPDGRTLAS-GSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
271-597 1.30e-23

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.22  E-value: 1.30e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132195 271 RHYRGHTDCVRCLAVHPDGVRVASGqtaGVDKdgkplqpVVHIWDSETLLKLQEigLGAFERGVGALAFSAadQGAFLcv 350
Cdd:COG2319   114 RTLTGHTGAVRSVAFSPDGKTLASG---SADG-------TVRLWDLATGKLLRT--LTGHSGAVTSVAFSP--DGKLL-- 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132195 351 VDDSNEHMLSVWDCSRGVKLAEIKSTNDSVLAVGFSPrDSSCIVTSGKSH-VHFWNWSGGTgapgngLLARKQGvfgkyk 429
Cdd:COG2319   178 ASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGtVRLWDLATGK------LLRTLTG------ 244

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132195 430 KPKFIPCFVFLPDGDIL-TGDSEGNILTWGRsvsdsktpgrggakETYTIVAQAHAHEGSIFALCLRRDGTVLSGGGRDR 508
Cdd:COG2319   245 HSGSVRSVAFSPDGRLLaSGSADGTVRLWDL--------------ATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDG 310

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132195 509 RLVQWGPGLVALQeAEIPEHFGAVRAIA-EGLGSELLVGTTKNALLRGDLAQG-FSPVIQGHTDELWGLCTHPSQNRFLT 586
Cdd:COG2319   311 TVRLWDLATGKLL-RTLTGHTGAVRSVAfSPDGKTLASGSDDGTVRLWDLATGeLLRTLTGHTGAVTSVAFSPDGRTLAS 389

                         330
                  ....*....|.
gi 1907132195 587 CGHDRQLCLWD 597
Cdd:COG2319   390 GSADGTVRLWD 400
 
Name Accession Description Interval E-value
HELP pfam03451
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm ...
 189-257 2.96e-32

HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.


Pssm-ID: 460922  Cd Length: 72  Bit Score: 119.58  E-value: 2.96e-32
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907132195 189 KMFLRGRPITMYIPSGIRSLEELPS--GPPPETLSLDWVYGYRGRDSRSNLFVLRSGEVVYFIACVVVLYR 257
Cdd:pfam03451   1 KMAIRGRPGAVYPPSNYYPKDDLDQkkEPPDKKLKLEWVYGYRGKDCRSNLYYLPTGEIVYFTAAVVVLYD 71
WD40 COG2319
WD40 repeat [General function prediction only];
477-841 3.43e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 118.09  E-value: 3.43e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132195 477 TIVAQAHAHEGSIFALCLRRDGTVLSGGGRDRRLVQWGPgLVALQEAEIPEHFGAVRAIA-EGLGSELLVGTTKNALLRG 555
Cdd:COG2319    69 ALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDL-ATGLLLRTLTGHTGAVRSVAfSPDGKTLASGSADGTVRLW 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132195 556 DLAQG-FSPVIQGHTDELWGLCTHPSQNRFLTCGHDRQLCLWDGEGHALAWSMDLKETGL-CADFHPSGAVVVVGLNTGR 633
Cdd:COG2319   148 DLATGkLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVrSVAFSPDGKLLASGSADGT 227

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132195 634 WLVLDTETREIVSDVTDGNEQLSVVRYSPDGLYLAIGSHDNMIYIYSVSScGTKSSRFGrcmGHSSFITHLDWSKDGNFI 713
Cdd:COG2319   228 VRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLAT-GELLRTLT---GHSGGVNSVAFSPDGKLL 303

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132195 714 MSNSGDYEILYWDVAGGcKLLRnryesrdrewatytcVLGFHVYGVWpdgsdgtdinSLCRSHNERVVAVADDFCKVHLF 793
Cdd:COG2319   304 ASGSDDGTVRLWDLATG-KLLR---------------TLTGHTGAVR----------SVAFSPDGKTLASGSDDGTVRLW 357

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 1907132195 794 QypcARAKAPSRMYSGHGSHVTSVRFTHDDSYLVSlGGKDASIFQWRV 841
Cdd:COG2319   358 D---LATGELLRTLTGHTGAVTSVAFSPDGRTLAS-GSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 523-840 1.02e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 110.89  E-value: 1.02e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132195 523 AEIPEHFGAVRAIAEGLGSELLVGTTKNALLRG-DLAQGFSP-VIQGHTDELWGLCTHPSQNRFLTCGHDRQLCLWDGEG 600
Cdd:cd00200     3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVwDLETGELLrTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132195 601 HALAWSMDL-KETGLCADFHPSGAVVVVGLNTGRWLVLDTETREIVSDVTDGNEQLSVVRYSPDGLYLAIGSHDNMIYIY 679
Cdd:cd00200    83 GECVRTLTGhTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLW 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132195 680 SVSSCgtksSRFGRCMGHSSFITHLDWSKDGNFIMSNSGDYEILYWDVAGGcKLLrnryesrdrewatytCVLGFHVYGV 759
Cdd:cd00200   163 DLRTG----KCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG-KCL---------------GTLRGHENGV 222

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132195 760 WpdgsdgtdinSLCRSHNERVVAVADDFCKVHLFQYpcaRAKAPSRMYSGHGSHVTSVRFTHDDSYLVSlGGKDASIFQW 839
Cdd:cd00200   223 N----------SVAFSPDGYLLASGSEDGTIRVWDL---RTGECVQTLSGHTNSVTSLAWSPDGKRLAS-GSADGTIRIW 288


                  .
gi 1907132195 840 R 840
Cdd:cd00200   289 D 289
WD40 COG2319
WD40 repeat [General function prediction only];
271-597 1.30e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.22  E-value: 1.30e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132195 271 RHYRGHTDCVRCLAVHPDGVRVASGqtaGVDKdgkplqpVVHIWDSETLLKLQEigLGAFERGVGALAFSAadQGAFLcv 350
Cdd:COG2319   114 RTLTGHTGAVRSVAFSPDGKTLASG---SADG-------TVRLWDLATGKLLRT--LTGHSGAVTSVAFSP--DGKLL-- 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132195 351 VDDSNEHMLSVWDCSRGVKLAEIKSTNDSVLAVGFSPrDSSCIVTSGKSH-VHFWNWSGGTgapgngLLARKQGvfgkyk 429
Cdd:COG2319   178 ASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGtVRLWDLATGK------LLRTLTG------ 244

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132195 430 KPKFIPCFVFLPDGDIL-TGDSEGNILTWGRsvsdsktpgrggakETYTIVAQAHAHEGSIFALCLRRDGTVLSGGGRDR 508
Cdd:COG2319   245 HSGSVRSVAFSPDGRLLaSGSADGTVRLWDL--------------ATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDG 310

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132195 509 RLVQWGPGLVALQeAEIPEHFGAVRAIA-EGLGSELLVGTTKNALLRGDLAQG-FSPVIQGHTDELWGLCTHPSQNRFLT 586
Cdd:COG2319   311 TVRLWDLATGKLL-RTLTGHTGAVRSVAfSPDGKTLASGSDDGTVRLWDLATGeLLRTLTGHTGAVTSVAFSPDGRTLAS 389

                         330
                  ....*....|.
gi 1907132195 587 CGHDRQLCLWD 597
Cdd:COG2319   390 GSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 271-597 8.62e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 90.47  E-value: 8.62e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132195 271 RHYRGHTDCVRCLAVHPDGVRVASGqtagvDKDGKplqpvVHIWDSETllKLQEIGLGAFERGVGALAFSAADQGAFLCv 350
Cdd:cd00200     3 RTLKGHTGGVTCVAFSPDGKLLATG-----SGDGT-----IKVWDLET--GELLRTLKGHTGPVRDVAASADGTYLASG- 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132195 351 vddSNEHMLSVWDCSRGVKLAEIKSTNDSVLAVGFSPrDSSCIVTSGKSH-VHFWNWSGGTgapgngLLARKQGvfgkyk 429
Cdd:cd00200    70 ---SSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSP-DGRILSSSSRDKtIKVWDVETGK------CLTTLRG------ 133

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132195 430 KPKFIPCFVFLPDGDILT-GDSEGNILTWgrsvsDSKTPgrggaketyTIVAQAHAHEGSIFALCLRRDGTVLSGGGRDR 508
Cdd:cd00200   134 HTDWVNSVAFSPDGTFVAsSSQDGTIKLW-----DLRTG---------KCVATLTGHTGEVNSVAFSPDGEKLLSSSSDG 199

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132195 509 RLVQWGPGLVALQeAEIPEHFGAVRAIAEGLGSELLVGTTKNALLRG-DLAQG-FSPVIQGHTDELWGLCTHPSQNRFLT 586
Cdd:cd00200   200 TIKLWDLSTGKCL-GTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVwDLRTGeCVQTLSGHTNSVTSLAWSPDGKRLAS 278

                         330
                  ....*....|.
gi 1907132195 587 CGHDRQLCLWD 597
Cdd:cd00200   279 GSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 564-597 3.81e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 3.81e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907132195  564 VIQGHTDELWGLCTHPSQNRFLTCGHDRQLCLWD 597
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
564-597 3.50e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 3.50e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1907132195 564 VIQGHTDELWGLCTHPSQNRFLTCGHDRQLCLWD 597
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 271-315 1.18e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 1.18e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1907132195  271 RHYRGHTDCVRCLAVHPDGVRVASGqtagvDKDGKplqpvVHIWD 315
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASG-----SDDGT-----IKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
270-315 3.27e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 3.27e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1907132195 270 QRHYRGHTDCVRCLAVHPDGVRVASGqtagvDKDGKplqpvVHIWD 315
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASG-----SDDGT-----VKVWD 39
 
Name Accession Description Interval E-value
HELP pfam03451
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm ...
 189-257 2.96e-32

HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.


Pssm-ID: 460922  Cd Length: 72  Bit Score: 119.58  E-value: 2.96e-32
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907132195 189 KMFLRGRPITMYIPSGIRSLEELPS--GPPPETLSLDWVYGYRGRDSRSNLFVLRSGEVVYFIACVVVLYR 257
Cdd:pfam03451   1 KMAIRGRPGAVYPPSNYYPKDDLDQkkEPPDKKLKLEWVYGYRGKDCRSNLYYLPTGEIVYFTAAVVVLYD 71
WD40 COG2319
WD40 repeat [General function prediction only];
477-841 3.43e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 118.09  E-value: 3.43e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132195 477 TIVAQAHAHEGSIFALCLRRDGTVLSGGGRDRRLVQWGPgLVALQEAEIPEHFGAVRAIA-EGLGSELLVGTTKNALLRG 555
Cdd:COG2319    69 ALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDL-ATGLLLRTLTGHTGAVRSVAfSPDGKTLASGSADGTVRLW 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132195 556 DLAQG-FSPVIQGHTDELWGLCTHPSQNRFLTCGHDRQLCLWDGEGHALAWSMDLKETGL-CADFHPSGAVVVVGLNTGR 633
Cdd:COG2319   148 DLATGkLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVrSVAFSPDGKLLASGSADGT 227

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132195 634 WLVLDTETREIVSDVTDGNEQLSVVRYSPDGLYLAIGSHDNMIYIYSVSScGTKSSRFGrcmGHSSFITHLDWSKDGNFI 713
Cdd:COG2319   228 VRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLAT-GELLRTLT---GHSGGVNSVAFSPDGKLL 303

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132195 714 MSNSGDYEILYWDVAGGcKLLRnryesrdrewatytcVLGFHVYGVWpdgsdgtdinSLCRSHNERVVAVADDFCKVHLF 793
Cdd:COG2319   304 ASGSDDGTVRLWDLATG-KLLR---------------TLTGHTGAVR----------SVAFSPDGKTLASGSDDGTVRLW 357

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 1907132195 794 QypcARAKAPSRMYSGHGSHVTSVRFTHDDSYLVSlGGKDASIFQWRV 841
Cdd:COG2319   358 D---LATGELLRTLTGHTGAVTSVAFSPDGRTLAS-GSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
283-729 2.00e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 115.78  E-value: 2.00e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132195 283 LAVHPDGVRVASGQTAGVDKDGKPLQPVVHIWDSETLLKLQEigLGAFERGVGALAFSAADQGaflcVVDDSNEHMLSVW 362
Cdd:COG2319    32 LLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLAT--LLGHTAAVLSVAFSPDGRL----LASASADGTVRLW 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132195 363 DCSRGVKLAEIKSTNDSVLAVGFSPrDSSCIVTSGKSH-VHFWNWSGGTgapgngLLARKQGvfgkykKPKFIPCFVFLP 441
Cdd:COG2319   106 DLATGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGtVRLWDLATGK------LLRTLTG------HSGAVTSVAFSP 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132195 442 DGDIL-TGDSEGNILTWgrsvsDSKTPgrggaKETYTIvaqaHAHEGSIFALCLRRDGTVLSGGGRDRRLVQWgpglval 520
Cdd:COG2319   173 DGKLLaSGSDDGTVRLW-----DLATG-----KLLRTL----TGHTGAVRSVAFSPDGKLLASGSADGTVRLW------- 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132195 521 qeaeipehfgavraiaeglgsellvgttknallrgDLAQGFSP-VIQGHTDELWGLCTHPSQNRFLTCGHDRQLCLWDGE 599
Cdd:COG2319   232 -----------------------------------DLATGKLLrTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLA 276

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132195 600 GHALAWSMDLKETGLCA-DFHPSGAVVVVGLNTGRWLVLDTETREIVSDVTDGNEQLSVVRYSPDGLYLAIGSHDNMIYI 678
Cdd:COG2319   277 TGELLRTLTGHSGGVNSvAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRL 356

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1907132195 679 YSVSScGTKSSRFGrcmGHSSFITHLDWSKDGNFIMSNSGDYEILYWDVAG 729
Cdd:COG2319   357 WDLAT-GELLRTLT---GHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 523-840 1.02e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 110.89  E-value: 1.02e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132195 523 AEIPEHFGAVRAIAEGLGSELLVGTTKNALLRG-DLAQGFSP-VIQGHTDELWGLCTHPSQNRFLTCGHDRQLCLWDGEG 600
Cdd:cd00200     3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVwDLETGELLrTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132195 601 HALAWSMDL-KETGLCADFHPSGAVVVVGLNTGRWLVLDTETREIVSDVTDGNEQLSVVRYSPDGLYLAIGSHDNMIYIY 679
Cdd:cd00200    83 GECVRTLTGhTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLW 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132195 680 SVSSCgtksSRFGRCMGHSSFITHLDWSKDGNFIMSNSGDYEILYWDVAGGcKLLrnryesrdrewatytCVLGFHVYGV 759
Cdd:cd00200   163 DLRTG----KCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG-KCL---------------GTLRGHENGV 222

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132195 760 WpdgsdgtdinSLCRSHNERVVAVADDFCKVHLFQYpcaRAKAPSRMYSGHGSHVTSVRFTHDDSYLVSlGGKDASIFQW 839
Cdd:cd00200   223 N----------SVAFSPDGYLLASGSEDGTIRVWDL---RTGECVQTLSGHTNSVTSLAWSPDGKRLAS-GSADGTIRIW 288


                  .
gi 1907132195 840 R 840
Cdd:cd00200   289 D 289
WD40 COG2319
WD40 repeat [General function prediction only];
494-841 5.51e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 108.46  E-value: 5.51e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132195 494 LRRDGTVLSGGGRDRRLVQWGPGLVALQEAEIPEHFGAVRAIAEGLGSELLVGTTKNALLRGDLAQG-FSPVIQGHTDEL 572
Cdd:COG2319     2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGaLLATLLGHTAAV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132195 573 WGLCTHPSQNRFLTCGHDRQLCLWDGE-GHALAWSMDLKETGLCADFHPSGAVVVVGLNTGRWLVLDTETREIVSDVTDG 651
Cdd:COG2319    82 LSVAFSPDGRLLASASADGTVRLWDLAtGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGH 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132195 652 NEQLSVVRYSPDGLYLAIGSHDNMIYIYSVSScGTKSSRFGrcmGHSSFITHLDWSKDGNFIMSNSGDYEILYWDVAGGc 731
Cdd:COG2319   162 SGAVTSVAFSPDGKLLASGSDDGTVRLWDLAT-GKLLRTLT---GHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG- 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132195 732 KLLRnryesrdrewatytcVLGFHVYGVWpdgsdgtdinSLCRSHNERVVAVADDFCKVHLFQypcARAKAPSRMYSGHG 811
Cdd:COG2319   237 KLLR---------------TLTGHSGSVR----------SVAFSPDGRLLASGSADGTVRLWD---LATGELLRTLTGHS 288

                         330       340       350
                  ....*....|....*....|....*....|
gi 1907132195 812 SHVTSVRFTHDDSYLVSlGGKDASIFQWRV 841
Cdd:COG2319   289 GGVNSVAFSPDGKLLAS-GSDDGTVRLWDL 317
WD40 COG2319
WD40 repeat [General function prediction only];
271-597 1.30e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.22  E-value: 1.30e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132195 271 RHYRGHTDCVRCLAVHPDGVRVASGqtaGVDKdgkplqpVVHIWDSETLLKLQEigLGAFERGVGALAFSAadQGAFLcv 350
Cdd:COG2319   114 RTLTGHTGAVRSVAFSPDGKTLASG---SADG-------TVRLWDLATGKLLRT--LTGHSGAVTSVAFSP--DGKLL-- 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132195 351 VDDSNEHMLSVWDCSRGVKLAEIKSTNDSVLAVGFSPrDSSCIVTSGKSH-VHFWNWSGGTgapgngLLARKQGvfgkyk 429
Cdd:COG2319   178 ASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGtVRLWDLATGK------LLRTLTG------ 244

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132195 430 KPKFIPCFVFLPDGDIL-TGDSEGNILTWGRsvsdsktpgrggakETYTIVAQAHAHEGSIFALCLRRDGTVLSGGGRDR 508
Cdd:COG2319   245 HSGSVRSVAFSPDGRLLaSGSADGTVRLWDL--------------ATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDG 310

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132195 509 RLVQWGPGLVALQeAEIPEHFGAVRAIA-EGLGSELLVGTTKNALLRGDLAQG-FSPVIQGHTDELWGLCTHPSQNRFLT 586
Cdd:COG2319   311 TVRLWDLATGKLL-RTLTGHTGAVRSVAfSPDGKTLASGSDDGTVRLWDLATGeLLRTLTGHTGAVTSVAFSPDGRTLAS 389

                         330
                  ....*....|.
gi 1907132195 587 CGHDRQLCLWD 597
Cdd:COG2319   390 GSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 370-680 1.15e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.17  E-value: 1.15e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132195 370 LAEIKSTNDSVLAVGFSPrDSSCIVTSGKSH-VHFWNWSGGTgapgngLLARKQGvfgkykKPKFIPCFVFLPDGD-ILT 447
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSP-DGKLLATGSGDGtIKVWDLETGE------LLRTLKG------HTGPVRDVAASADGTyLAS 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132195 448 GDSEGNILTWgrsvsDSKTPgrggaKETYTIvaqaHAHEGSIFALCLRRDGTVLSGGGRDRRLVQWgPGLVALQEAEIPE 527
Cdd:cd00200    69 GSSDKTIRLW-----DLETG-----ECVRTL----TGHTSYVSSVAFSPDGRILSSSSRDKTIKVW-DVETGKCLTTLRG 133

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132195 528 HFGAVRAIAEGLGSELLVGTTKNALLR-GDLAQGfSPV--IQGHTDELWGLCTHPSQNRFLTCGHDRQLCLWD-GEGHAL 603
Cdd:cd00200   134 HTDWVNSVAFSPDGTFVASSSQDGTIKlWDLRTG-KCVatLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDlSTGKCL 212

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907132195 604 AwSMDLKETGLCA-DFHPSGAVVVVGLNTGRWLVLDTETREIVSDVTDGNEQLSVVRYSPDGLYLAIGSHDNMIYIYS 680
Cdd:cd00200   213 G-TLRGHENGVNSvAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 271-597 8.62e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 90.47  E-value: 8.62e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132195 271 RHYRGHTDCVRCLAVHPDGVRVASGqtagvDKDGKplqpvVHIWDSETllKLQEIGLGAFERGVGALAFSAADQGAFLCv 350
Cdd:cd00200     3 RTLKGHTGGVTCVAFSPDGKLLATG-----SGDGT-----IKVWDLET--GELLRTLKGHTGPVRDVAASADGTYLASG- 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132195 351 vddSNEHMLSVWDCSRGVKLAEIKSTNDSVLAVGFSPrDSSCIVTSGKSH-VHFWNWSGGTgapgngLLARKQGvfgkyk 429
Cdd:cd00200    70 ---SSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSP-DGRILSSSSRDKtIKVWDVETGK------CLTTLRG------ 133

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132195 430 KPKFIPCFVFLPDGDILT-GDSEGNILTWgrsvsDSKTPgrggaketyTIVAQAHAHEGSIFALCLRRDGTVLSGGGRDR 508
Cdd:cd00200   134 HTDWVNSVAFSPDGTFVAsSSQDGTIKLW-----DLRTG---------KCVATLTGHTGEVNSVAFSPDGEKLLSSSSDG 199

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132195 509 RLVQWGPGLVALQeAEIPEHFGAVRAIAEGLGSELLVGTTKNALLRG-DLAQG-FSPVIQGHTDELWGLCTHPSQNRFLT 586
Cdd:cd00200   200 TIKLWDLSTGKCL-GTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVwDLRTGeCVQTLSGHTNSVTSLAWSPDGKRLAS 278

                         330
                  ....*....|.
gi 1907132195 587 CGHDRQLCLWD 597
Cdd:cd00200   279 GSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 696-841 2.24e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 53.49  E-value: 2.24e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132195 696 GHSSFITHLDWSKDGNFIMSNSGDYEILYWDVAGGCKLLRNRyesrdrewatytcvlgfhvygvwpdGSDGTDINSLCRS 775
Cdd:cd00200     7 GHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLK-------------------------GHTGPVRDVAASA 61

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907132195 776 HNERVVAVADDFCkVHLFQYpcaRAKAPSRMYSGHGSHVTSVRFTHDDSYLVSlGGKDASIFQWRV 841
Cdd:cd00200    62 DGTYLASGSSDKT-IRLWDL---ETGECVRTLTGHTSYVSSVAFSPDGRILSS-SSRDKTIKVWDV 122
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 564-597 3.81e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 3.81e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907132195  564 VIQGHTDELWGLCTHPSQNRFLTCGHDRQLCLWD 597
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
564-597 3.50e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 3.50e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1907132195 564 VIQGHTDELWGLCTHPSQNRFLTCGHDRQLCLWD 597
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 694-726 9.13e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 9.13e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907132195  694 CMGHSSFITHLDWSKDGNFIMSNSGDYEILYWD 726
Cdd:smart00320   8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 271-315 1.18e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 1.18e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1907132195  271 RHYRGHTDCVRCLAVHPDGVRVASGqtagvDKDGKplqpvVHIWD 315
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASG-----SDDGT-----IKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 803-839 3.04e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.14  E-value: 3.04e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1907132195  803 PSRMYSGHGSHVTSVRFTHDDSYLVSlGGKDASIFQW 839
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLAS-GSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
270-315 3.27e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 3.27e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1907132195 270 QRHYRGHTDCVRCLAVHPDGVRVASGqtagvDKDGKplqpvVHIWD 315
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASG-----SDDGT-----VKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
696-726 4.99e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 4.99e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1907132195 696 GHSSFITHLDWSKDGNFIMSNSGDYEILYWD 726
Cdd:pfam00400   9 GHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
803-839 8.09e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 8.09e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1907132195 803 PSRMYSGHGSHVTSVRFTHDDSYLVSlGGKDASIFQW 839
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLAS-GSDDGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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