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Conserved domains on  [gi|1907152274|ref|XP_036019241|]
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ATP-dependent DNA/RNA helicase DHX36 isoform X1 [Mus musculus]

Protein Classification

ATP-dependent RNA helicase( domain architecture ID 13388279)

DEAD/DEAH box containing ATP-dependent RNA helicase catalyzes the unwinding of RNA, similar to DEAH box protein 34 (DHX34) that is required for nonsense-mediated decay (NMD) degradation of mRNA transcripts containing premature stop codons

CATH:  3.40.50.300
EC:  3.6.4.13
Gene Ontology:  GO:0005524|GO:0003724|GO:0003676|GO:0016887|GO:0003723
PubMed:  34680866|19747077|22922795|20206133|21779027|20225155

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HrpA super family cl34328
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
41-492 8.74e-83

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG1643:

Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 280.04  E-value: 8.74e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152274  41 LSSVSHIVLDEIHERNLQSDVLMTVIKDLLH-FRSDLKVILMSATLNAEKFSEYFGNCPMIHIPGFTFPVveyllediiE 119
Cdd:COG1643   121 LEGVDTVIFDEFHERSLNADLLLALLLDLQPaLRPDLKLLVMSATLDAERFARLLGDAPVIESSGRTYPV---------E 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152274 120 kIRYVPDQKEHRSQfkrgfmqghvnrqekeekeaiykerwpayikelrtrysastvdvlqmmdddkvdLNLIAALIRyIV 199
Cdd:COG1643   192 -VRYRPLPADERDL------------------------------------------------------EDAVADAVR-EA 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152274 200 LEEEDGAILVFLPGWDNISTLHDLLMSQVmfkSDKFLIIPLHSLMPTVNQTQVFKKTPPGVRKIVIATNIAETSITIDDV 279
Cdd:COG1643   216 LAEEPGDILVFLPGEREIRRTAEALRGRL---PPDTEILPLYGRLSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPGI 292

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152274 280 VYVIDGGKIKETHFDTQNNISTMSAEWVSKANAKQRKGRAGRVQPGHCYHLYNGLRASLLDDYQLPEILRTPLEELCLQI 359
Cdd:COG1643   293 RYVIDSGLARIPRYDPRSGVTRLPTERISQASANQRAGRAGRLAPGICYRLWSEEDFARRPAFTDPEILRADLASLILEL 372

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152274 360 KILRLGGIAYFlsRLMDPPS----NEAVVLsikhLMELSALDKQEELTPLGVHLARLPVEPHIGKMILFGALFCCLDPVL 435
Cdd:COG1643   373 AAWGLGDPEDL--PFLDPPParaiADARAL----LQELGALDADGRLTPLGRALARLPLDPRLARMLLAAAELGCLREAA 446

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1907152274 436 TIAASLSFKDPfviplgkekiadaRRkelaKETRSDHLTVVNAFEGWEEAKRRGFRY 492
Cdd:COG1643   447 ILAALLSERDP-------------RR----GAAGSDLLARLNLWRRLREQQREFLSY 486
OB_NTP_bind pfam07717
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ...
 547-633 7.09e-18

Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.


:

Pssm-ID: 400182 [Multi-domain]  Cd Length: 82  Bit Score: 78.83  E-value: 7.09e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152274 547 IKAVICAGLYPKVAKiRLNLGKKRKmvkvHTKSDGLVSIHPKSVNVEQTDFHYNWLIYHLKMRTSSIYLYDCTEVSPYCL 626
Cdd:pfam07717   1 LRAALAAGLYPNVAR-RDPKGKGYT----TLSDNQRVFIHPSSVLFNEKTFPPEWVVYQELVETTKVYIRTVTAISPEWL 75


                  ....*..
gi 1907152274 627 LFFGGDI 633
Cdd:pfam07717  76 LLFAPHI 82
 
Name Accession Description Interval E-value
HrpA COG1643
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
41-492 8.74e-83

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 280.04  E-value: 8.74e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152274  41 LSSVSHIVLDEIHERNLQSDVLMTVIKDLLH-FRSDLKVILMSATLNAEKFSEYFGNCPMIHIPGFTFPVveyllediiE 119
Cdd:COG1643   121 LEGVDTVIFDEFHERSLNADLLLALLLDLQPaLRPDLKLLVMSATLDAERFARLLGDAPVIESSGRTYPV---------E 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152274 120 kIRYVPDQKEHRSQfkrgfmqghvnrqekeekeaiykerwpayikelrtrysastvdvlqmmdddkvdLNLIAALIRyIV 199
Cdd:COG1643   192 -VRYRPLPADERDL------------------------------------------------------EDAVADAVR-EA 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152274 200 LEEEDGAILVFLPGWDNISTLHDLLMSQVmfkSDKFLIIPLHSLMPTVNQTQVFKKTPPGVRKIVIATNIAETSITIDDV 279
Cdd:COG1643   216 LAEEPGDILVFLPGEREIRRTAEALRGRL---PPDTEILPLYGRLSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPGI 292

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152274 280 VYVIDGGKIKETHFDTQNNISTMSAEWVSKANAKQRKGRAGRVQPGHCYHLYNGLRASLLDDYQLPEILRTPLEELCLQI 359
Cdd:COG1643   293 RYVIDSGLARIPRYDPRSGVTRLPTERISQASANQRAGRAGRLAPGICYRLWSEEDFARRPAFTDPEILRADLASLILEL 372

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152274 360 KILRLGGIAYFlsRLMDPPS----NEAVVLsikhLMELSALDKQEELTPLGVHLARLPVEPHIGKMILFGALFCCLDPVL 435
Cdd:COG1643   373 AAWGLGDPEDL--PFLDPPParaiADARAL----LQELGALDADGRLTPLGRALARLPLDPRLARMLLAAAELGCLREAA 446

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1907152274 436 TIAASLSFKDPfviplgkekiadaRRkelaKETRSDHLTVVNAFEGWEEAKRRGFRY 492
Cdd:COG1643   447 ILAALLSERDP-------------RR----GAAGSDLLARLNLWRRLREQQREFLSY 486
SF2_C_RHA cd18791
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ...
 179-331 7.82e-78

C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350178 [Multi-domain]  Cd Length: 171  Bit Score: 246.68  E-value: 7.82e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152274 179 QMMDDDKVDLNLIAALIRYIVLEEEDGAILVFLPGWDNISTLHDLLMSQVMFKS-DKFLIIPLHSLMPTVNQTQVFKKTP 257
Cdd:cd18791    18 SSEKEDPDYVDAAVRLILQIHRTEEPGDILVFLPGQEEIERLCELLREELLSPDlGKLLVLPLHSSLPPEEQQRVFEPPP 97

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907152274 258 PGVRKIVIATNIAETSITIDDVVYVIDGGKIKETHFDTQNNISTMSAEWVSKANAKQRKGRAGRVQPGHCYHLY 331
Cdd:cd18791    98 PGVRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISKASAEQRAGRAGRTRPGKCYRLY 171
PRK11131 PRK11131
ATP-dependent RNA helicase HrpA; Provisional
 47-477 5.82e-61

ATP-dependent RNA helicase HrpA; Provisional


Pssm-ID: 182986 [Multi-domain]  Cd Length: 1294  Bit Score: 222.63  E-value: 5.82e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152274   47 IVLDEIHERNLQSDVLMTVIKDLLHFRSDLKVILMSATLNAEKFSEYFGNCPMIHIPGFTFPVveyllediieKIRYVPd 126
Cdd:PRK11131   190 IIIDEAHERSLNIDFILGYLKELLPRRPDLKVIITSATIDPERFSRHFNNAPIIEVSGRTYPV----------EVRYRP- 258

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152274  127 qkehrsqfkrgfMQGHVNRQEKEEKEAIYkerwpayikelrtrysaSTVDVLQmmdddkvdlnliaaliryivlEEEDGA 206
Cdd:PRK11131   259 ------------IVEEADDTERDQLQAIF-----------------DAVDELG---------------------REGPGD 288

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152274  207 ILVFLPGWDNISTLHDLLMSQVMFKSDkflIIPLHSLMPTVNQTQVFKktPPGVRKIVIATNIAETSITIDDVVYVIDGG 286
Cdd:PRK11131   289 ILIFMSGEREIRDTADALNKLNLRHTE---ILPLYARLSNSEQNRVFQ--SHSGRRIVLATNVAETSLTVPGIKYVIDPG 363

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152274  287 KIKETHFDTQNNISTMSAEWVSKANAKQRKGRAGRVQPGHCYHLYNGL----RASLLDdyqlPEILRTPLEELCLQIKIL 362
Cdd:PRK11131   364 TARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVSEGICIRLYSEDdflsRPEFTD----PEILRTNLASVILQMTAL 439

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152274  363 RLGGIAYFlsRLMDPPSNEAVVLSIKHLMELSALDKQE-----ELTPLGVHLARLPVEPHIGKMILFGALFCCLDPVLTI 437
Cdd:PRK11131   440 GLGDIAAF--PFVEAPDKRNIQDGVRLLEELGAITTDEqasayKLTPLGRQLAQLPVDPRLARMVLEAQKHGCVREVMII 517

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|
gi 1907152274  438 AASLSFKDPFVIPLGKEKIADARRKELAKEtRSDHLTVVN 477
Cdd:PRK11131   518 TSALSIQDPRERPMDKQQASDEKHRRFADK-ESDFLAFVN 556
DEAH_box_HrpB TIGR01970
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but ...
 41-461 9.27e-53

ATP-dependent helicase HrpB; This model represents HrpB, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria, but also in a few species of other lineages. The member from Rhizobium meliloti has been designated HelO. HrpB is typically about 800 residues in length, while its paralog HrpA (TIGR01967), also uncharacterized, is about 1300 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 273901 [Multi-domain]  Cd Length: 819  Bit Score: 196.14  E-value: 9.27e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152274  41 LSSVSHIVLDEIHERNLQSDVLMTVIKDLLH-FRSDLKVILMSATLNAEKFSEYFGNCPMIHIPGFTFPVveyllediie 119
Cdd:TIGR01970 111 LDGVGALIFDEFHERSLDADLGLALALDVQSsLREDLKILAMSATLDGERLSSLLPDAPVVESEGRSFPV---------- 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152274 120 KIRYVPDQKEHRsqfkrgfMQGHVNRQekeekeaiykerwpayikelrtrysastvdVLQMmdddkvdlnliaaliryiv 199
Cdd:TIGR01970 181 EIRYLPLRGDQR-------LEDAVSRA------------------------------VEHA------------------- 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152274 200 LEEEDGAILVFLPGWDNI----STLHDLLMSQVmfksdkfLIIPLHSLMPTVNQTQVFKKTPPGVRKIVIATNIAETSIT 275
Cdd:TIGR01970 205 LASETGSILVFLPGQAEIrrvqEQLAERLDSDV-------LICPLYGELSLAAQDRAIKPDPQGRRKVVLATNIAETSLT 277

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152274 276 IDDVVYVIDGGKIKETHFDTQNNISTMSAEWVSKANAKQRKGRAGRVQPGHCYHLYNGLRASLLDDYQLPEILRTPLEEL 355
Cdd:TIGR01970 278 IEGIRVVIDSGLARVARFDPKTGITRLETVRISQASATQRAGRAGRLEPGVCYRLWSEEQHQRLPAQDEPEILQADLSGL 357

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152274 356 CLQikILRLGGIAYFLSRLMDPPSNEAVVLSIKHLMELSALDKQEELTPLGVHLARLPVEPHIGKMILFG------ALFC 429
Cdd:TIGR01970 358 ALE--LAQWGAKDPSDLRWLDAPPSVALAAARQLLQRLGALDAQGRLTAHGKAMAALGCHPRLAAMLLSAhstglaALAC 435

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|...
gi 1907152274 430 CLDPVLT-----------IAASLSFKDPFVIPLGKEKIADARR 461
Cdd:TIGR01970 436 DLAALLEerglprqggadLMNRLHRLQQGRQGRGQRAQQLAKK 478
HA2 pfam04408
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ...
 386-475 2.57e-27

Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 461295 [Multi-domain]  Cd Length: 104  Bit Score: 106.55  E-value: 2.57e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152274 386 SIKHLMELSALDKQEELTPLGVHLARLPVEPHIGKMILFGALFCCLDPVLTIAASLSFKDPFVIPLG------------- 452
Cdd:pfam04408   1 ALELLYYLGALDEDGELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFVQPNFldprsaakaarrr 80

                          90       100
                  ....*....|....*....|....
gi 1907152274 453 -KEKIADARRKELAKETRSDHLTV 475
Cdd:pfam04408  81 rRAADEKARAKFARLDLEGDHLTL 104
HA2 smart00847
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ...
 392-476 1.31e-24

Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 214852 [Multi-domain]  Cd Length: 82  Bit Score: 97.72  E-value: 1.31e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152274  392 ELSALDKQEELTPLGVHLARLPVEPHIGKMILFGALFCCLDPVLTIAASLSFKDPFviPLGKEKIADARRKELAKEtRSD 471
Cdd:smart00847   1 ELGALDDDGRLTPLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGDPR--PKEKREDADAARRRFADP-ESD 77


                   ....*
gi 1907152274  472 HLTVV 476
Cdd:smart00847  78 HLTLL 82
OB_NTP_bind pfam07717
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ...
 547-633 7.09e-18

Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.


Pssm-ID: 400182 [Multi-domain]  Cd Length: 82  Bit Score: 78.83  E-value: 7.09e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152274 547 IKAVICAGLYPKVAKiRLNLGKKRKmvkvHTKSDGLVSIHPKSVNVEQTDFHYNWLIYHLKMRTSSIYLYDCTEVSPYCL 626
Cdd:pfam07717   1 LRAALAAGLYPNVAR-RDPKGKGYT----TLSDNQRVFIHPSSVLFNEKTFPPEWVVYQELVETTKVYIRTVTAISPEWL 75


                  ....*..
gi 1907152274 627 LFFGGDI 633
Cdd:pfam07717  76 LLFAPHI 82
 
Name Accession Description Interval E-value
HrpA COG1643
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
41-492 8.74e-83

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 280.04  E-value: 8.74e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152274  41 LSSVSHIVLDEIHERNLQSDVLMTVIKDLLH-FRSDLKVILMSATLNAEKFSEYFGNCPMIHIPGFTFPVveyllediiE 119
Cdd:COG1643   121 LEGVDTVIFDEFHERSLNADLLLALLLDLQPaLRPDLKLLVMSATLDAERFARLLGDAPVIESSGRTYPV---------E 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152274 120 kIRYVPDQKEHRSQfkrgfmqghvnrqekeekeaiykerwpayikelrtrysastvdvlqmmdddkvdLNLIAALIRyIV 199
Cdd:COG1643   192 -VRYRPLPADERDL------------------------------------------------------EDAVADAVR-EA 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152274 200 LEEEDGAILVFLPGWDNISTLHDLLMSQVmfkSDKFLIIPLHSLMPTVNQTQVFKKTPPGVRKIVIATNIAETSITIDDV 279
Cdd:COG1643   216 LAEEPGDILVFLPGEREIRRTAEALRGRL---PPDTEILPLYGRLSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPGI 292

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152274 280 VYVIDGGKIKETHFDTQNNISTMSAEWVSKANAKQRKGRAGRVQPGHCYHLYNGLRASLLDDYQLPEILRTPLEELCLQI 359
Cdd:COG1643   293 RYVIDSGLARIPRYDPRSGVTRLPTERISQASANQRAGRAGRLAPGICYRLWSEEDFARRPAFTDPEILRADLASLILEL 372

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152274 360 KILRLGGIAYFlsRLMDPPS----NEAVVLsikhLMELSALDKQEELTPLGVHLARLPVEPHIGKMILFGALFCCLDPVL 435
Cdd:COG1643   373 AAWGLGDPEDL--PFLDPPParaiADARAL----LQELGALDADGRLTPLGRALARLPLDPRLARMLLAAAELGCLREAA 446

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1907152274 436 TIAASLSFKDPfviplgkekiadaRRkelaKETRSDHLTVVNAFEGWEEAKRRGFRY 492
Cdd:COG1643   447 ILAALLSERDP-------------RR----GAAGSDLLARLNLWRRLREQQREFLSY 486
SF2_C_RHA cd18791
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ...
 179-331 7.82e-78

C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350178 [Multi-domain]  Cd Length: 171  Bit Score: 246.68  E-value: 7.82e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152274 179 QMMDDDKVDLNLIAALIRYIVLEEEDGAILVFLPGWDNISTLHDLLMSQVMFKS-DKFLIIPLHSLMPTVNQTQVFKKTP 257
Cdd:cd18791    18 SSEKEDPDYVDAAVRLILQIHRTEEPGDILVFLPGQEEIERLCELLREELLSPDlGKLLVLPLHSSLPPEEQQRVFEPPP 97

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907152274 258 PGVRKIVIATNIAETSITIDDVVYVIDGGKIKETHFDTQNNISTMSAEWVSKANAKQRKGRAGRVQPGHCYHLY 331
Cdd:cd18791    98 PGVRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISKASAEQRAGRAGRTRPGKCYRLY 171
PRK11131 PRK11131
ATP-dependent RNA helicase HrpA; Provisional
 47-477 5.82e-61

ATP-dependent RNA helicase HrpA; Provisional


Pssm-ID: 182986 [Multi-domain]  Cd Length: 1294  Bit Score: 222.63  E-value: 5.82e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152274   47 IVLDEIHERNLQSDVLMTVIKDLLHFRSDLKVILMSATLNAEKFSEYFGNCPMIHIPGFTFPVveyllediieKIRYVPd 126
Cdd:PRK11131   190 IIIDEAHERSLNIDFILGYLKELLPRRPDLKVIITSATIDPERFSRHFNNAPIIEVSGRTYPV----------EVRYRP- 258

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152274  127 qkehrsqfkrgfMQGHVNRQEKEEKEAIYkerwpayikelrtrysaSTVDVLQmmdddkvdlnliaaliryivlEEEDGA 206
Cdd:PRK11131   259 ------------IVEEADDTERDQLQAIF-----------------DAVDELG---------------------REGPGD 288

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152274  207 ILVFLPGWDNISTLHDLLMSQVMFKSDkflIIPLHSLMPTVNQTQVFKktPPGVRKIVIATNIAETSITIDDVVYVIDGG 286
Cdd:PRK11131   289 ILIFMSGEREIRDTADALNKLNLRHTE---ILPLYARLSNSEQNRVFQ--SHSGRRIVLATNVAETSLTVPGIKYVIDPG 363

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152274  287 KIKETHFDTQNNISTMSAEWVSKANAKQRKGRAGRVQPGHCYHLYNGL----RASLLDdyqlPEILRTPLEELCLQIKIL 362
Cdd:PRK11131   364 TARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVSEGICIRLYSEDdflsRPEFTD----PEILRTNLASVILQMTAL 439

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152274  363 RLGGIAYFlsRLMDPPSNEAVVLSIKHLMELSALDKQE-----ELTPLGVHLARLPVEPHIGKMILFGALFCCLDPVLTI 437
Cdd:PRK11131   440 GLGDIAAF--PFVEAPDKRNIQDGVRLLEELGAITTDEqasayKLTPLGRQLAQLPVDPRLARMVLEAQKHGCVREVMII 517

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|
gi 1907152274  438 AASLSFKDPFVIPLGKEKIADARRKELAKEtRSDHLTVVN 477
Cdd:PRK11131   518 TSALSIQDPRERPMDKQQASDEKHRRFADK-ESDFLAFVN 556
DEAH_box_HrpB TIGR01970
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but ...
 41-461 9.27e-53

ATP-dependent helicase HrpB; This model represents HrpB, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria, but also in a few species of other lineages. The member from Rhizobium meliloti has been designated HelO. HrpB is typically about 800 residues in length, while its paralog HrpA (TIGR01967), also uncharacterized, is about 1300 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 273901 [Multi-domain]  Cd Length: 819  Bit Score: 196.14  E-value: 9.27e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152274  41 LSSVSHIVLDEIHERNLQSDVLMTVIKDLLH-FRSDLKVILMSATLNAEKFSEYFGNCPMIHIPGFTFPVveyllediie 119
Cdd:TIGR01970 111 LDGVGALIFDEFHERSLDADLGLALALDVQSsLREDLKILAMSATLDGERLSSLLPDAPVVESEGRSFPV---------- 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152274 120 KIRYVPDQKEHRsqfkrgfMQGHVNRQekeekeaiykerwpayikelrtrysastvdVLQMmdddkvdlnliaaliryiv 199
Cdd:TIGR01970 181 EIRYLPLRGDQR-------LEDAVSRA------------------------------VEHA------------------- 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152274 200 LEEEDGAILVFLPGWDNI----STLHDLLMSQVmfksdkfLIIPLHSLMPTVNQTQVFKKTPPGVRKIVIATNIAETSIT 275
Cdd:TIGR01970 205 LASETGSILVFLPGQAEIrrvqEQLAERLDSDV-------LICPLYGELSLAAQDRAIKPDPQGRRKVVLATNIAETSLT 277

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152274 276 IDDVVYVIDGGKIKETHFDTQNNISTMSAEWVSKANAKQRKGRAGRVQPGHCYHLYNGLRASLLDDYQLPEILRTPLEEL 355
Cdd:TIGR01970 278 IEGIRVVIDSGLARVARFDPKTGITRLETVRISQASATQRAGRAGRLEPGVCYRLWSEEQHQRLPAQDEPEILQADLSGL 357

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152274 356 CLQikILRLGGIAYFLSRLMDPPSNEAVVLSIKHLMELSALDKQEELTPLGVHLARLPVEPHIGKMILFG------ALFC 429
Cdd:TIGR01970 358 ALE--LAQWGAKDPSDLRWLDAPPSVALAAARQLLQRLGALDAQGRLTAHGKAMAALGCHPRLAAMLLSAhstglaALAC 435

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|...
gi 1907152274 430 CLDPVLT-----------IAASLSFKDPFVIPLGKEKIADARR 461
Cdd:TIGR01970 436 DLAALLEerglprqggadLMNRLHRLQQGRQGRGQRAQQLAKK 478
PRK11664 PRK11664
ATP-dependent RNA helicase HrpB; Provisional
 41-426 4.04e-45

ATP-dependent RNA helicase HrpB; Provisional


Pssm-ID: 236950 [Multi-domain]  Cd Length: 812  Bit Score: 173.19  E-value: 4.04e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152274  41 LSSVSHIVLDEIHERNLQSDV----LMTVIKDLlhfRSDLKVILMSATLNAEKFSEYFGNCPMIHIPGFTFPVveylled 116
Cdd:PRK11664  114 LSGVGLVILDEFHERSLQADLalalLLDVQQGL---RDDLKLLIMSATLDNDRLQQLLPDAPVIVSEGRSFPV------- 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152274 117 iieKIRYVPdqkehrsqfkrgfmqghVNRQEKEEkEAIYKErwpayikelrtrysastvdVLQMMDddkvdlnliaalir 196
Cdd:PRK11664  184 ---ERRYQP-----------------LPAHQRFD-EAVARA-------------------TAELLR-------------- 209

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152274 197 yivleEEDGAILVFLPGWDNISTLHDLLMSQVmfkSDKFLIIPLHSLMPTVNQTQVFKKTPPGVRKIVIATNIAETSITI 276
Cdd:PRK11664  210 -----QESGSLLLFLPGVGEIQRVQEQLASRV---ASDVLLCPLYGALSLAEQQKAILPAPAGRRKVVLATNIAETSLTI 281

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152274 277 DDVVYVIDGGKIKETHFDTQNNISTMSAEWVSKANAKQRKGRAGRVQPGHCYHLYNGLRASLLDDYQLPEILRTPLEELC 356
Cdd:PRK11664  282 EGIRLVVDSGLERVARFDPKTGLTRLVTQRISQASMTQRAGRAGRLEPGICLHLYSKEQAERAAAQSEPEILHSDLSGLL 361

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907152274 357 LQikILRLGgiAYFLSRLM--DPPSNEAVVLSIKHLMELSALDKQEELTPLGVHLARLPVEPHIGKMILFGA 426
Cdd:PRK11664  362 LE--LLQWG--CHDPAQLSwlDQPPAAALAAAKRLLQQLGALDGQGRLTARGRKMAALGNDPRLAAMLVAAK 429
DEXHc_DHX36 cd17981
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ...
 41-102 2.48e-34

DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350739 [Multi-domain]  Cd Length: 180  Bit Score: 129.19  E-value: 2.48e-34
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907152274  41 LSSVSHIVLDEIHERNLQSDVLMTVIKDLLHFRSDLKVILMSATLNAEKFSEYFGNCPMIHI 102
Cdd:cd17981   119 LSNVSHLVLDEIHERNLQSDVLMGIVKDLLPFRSDLKVILMSATLNAEKFSDYFNNCPMIHI 180
DEXHc_RHA-like cd17917
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) ...
 41-102 9.78e-31

DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438707 [Multi-domain]  Cd Length: 159  Bit Score: 117.95  E-value: 9.78e-31
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907152274  41 LSSVSHIVLDEIHERNLQSDVLMTVIKDLLHFRSDLKVILMSATLNAEKFSEYFGNCPMIHI 102
Cdd:cd17917    98 LSGYSHVILDEAHERSLDTDFLLGLLKDLLRKRPDLKVILMSATLDAEKFSSYFGGAPVIHI 159
HA2 pfam04408
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ...
 386-475 2.57e-27

Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 461295 [Multi-domain]  Cd Length: 104  Bit Score: 106.55  E-value: 2.57e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152274 386 SIKHLMELSALDKQEELTPLGVHLARLPVEPHIGKMILFGALFCCLDPVLTIAASLSFKDPFVIPLG------------- 452
Cdd:pfam04408   1 ALELLYYLGALDEDGELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFVQPNFldprsaakaarrr 80

                          90       100
                  ....*....|....*....|....
gi 1907152274 453 -KEKIADARRKELAKETRSDHLTV 475
Cdd:pfam04408  81 rRAADEKARAKFARLDLEGDHLTL 104
HA2 smart00847
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ...
 392-476 1.31e-24

Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 214852 [Multi-domain]  Cd Length: 82  Bit Score: 97.72  E-value: 1.31e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152274  392 ELSALDKQEELTPLGVHLARLPVEPHIGKMILFGALFCCLDPVLTIAASLSFKDPFviPLGKEKIADARRKELAKEtRSD 471
Cdd:smart00847   1 ELGALDDDGRLTPLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGDPR--PKEKREDADAARRRFADP-ESD 77


                   ....*
gi 1907152274  472 HLTVV 476
Cdd:smart00847  78 HLTLL 82
DEXHc_DHX57 cd17985
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the ...
 41-102 2.19e-23

DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350743 [Multi-domain]  Cd Length: 177  Bit Score: 97.60  E-value: 2.19e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907152274  41 LSSVSHIVLDEIHERNLQSDVLMTVIKDLLHFRSDLKVILMSATLNAEKFSEYFGNCPMIHI 102
Cdd:cd17985   116 LQGVTHVIVDEVHERTEESDFLLLVLKDLMVQRPDLKVILMSATLNAELFSDYFNSCPVIHI 177
DEXHc_DHX29 cd17975
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of ...
 41-102 7.35e-23

DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of the 43S pre-initiation complex involved in translation initiation of mRNAs with structured 5'-UTRs. DHX29 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350733 [Multi-domain]  Cd Length: 183  Bit Score: 96.52  E-value: 7.35e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907152274  41 LSSVSHIVLDEIHERNLQSDVLMTVIKDLLHFRSDLKVILMSATLNAEKFSEYFGNCPMIHI 102
Cdd:cd17975   122 LSSISHIIVDEVHERSVQSDFLLIILKEILHKRSDLHLILMSATVDCEKFSSYFTHCPILRI 183
DEXHc_DHX15 cd17973
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA ...
 41-102 1.22e-19

DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. DHX15 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438709 [Multi-domain]  Cd Length: 187  Bit Score: 87.09  E-value: 1.22e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907152274  41 LSSVSHIVLDEIHERNLQSDVLMTVIKDLLHFRSDLKVILMSATLNAEKFSEYFGNCPMIHI 102
Cdd:cd17973   126 LSRYSVIILDEAHERTLATDILMGLLKEVVRRRPDLKLIVMSATLDAGKFQKYFDNAPLLKV 187
DEXHc_DHX8 cd17971
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as ...
 41-103 1.80e-18

DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22) acts late in the splicing of pre-mRNA and mediates the release of the spliced mRNA from spliceosomes. DHX8 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350729 [Multi-domain]  Cd Length: 179  Bit Score: 83.69  E-value: 1.80e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907152274  41 LSSVSHIVLDEIHERNLQSDVLMTVIKDLLHFRSDLKVILMSATLNAEKFSEYFGNCPMIHIP 103
Cdd:cd17971   117 LSQYSVIMLDEAHERTIHTDVLFGLLKKTVQKRPDLKLIVTSATLDAVKFSQYFYEAPIFTIP 179
DEXHc_DHX30 cd17976
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an ...
 40-102 5.40e-18

DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an important role in the assembly of the mitochondrial large ribosomal subunit. DHX30 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350734 [Multi-domain]  Cd Length: 178  Bit Score: 82.15  E-value: 5.40e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907152274  40 RLSSVSHIVLDEIHERNLQSDVLMTVIKDLLHFRSDLKVILMSATLNAEKFSEYFGNCPMIHI 102
Cdd:cd17976   116 RLEGVSHVIVDEVHERDVNTDFLLILLKGVLQLNPELRVVLMSATGDNQRLSRYFGGCPVVRV 178
OB_NTP_bind pfam07717
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ...
 547-633 7.09e-18

Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.


Pssm-ID: 400182 [Multi-domain]  Cd Length: 82  Bit Score: 78.83  E-value: 7.09e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152274 547 IKAVICAGLYPKVAKiRLNLGKKRKmvkvHTKSDGLVSIHPKSVNVEQTDFHYNWLIYHLKMRTSSIYLYDCTEVSPYCL 626
Cdd:pfam07717   1 LRAALAAGLYPNVAR-RDPKGKGYT----TLSDNQRVFIHPSSVLFNEKTFPPEWVVYQELVETTKVYIRTVTAISPEWL 75


                  ....*..
gi 1907152274 627 LFFGGDI 633
Cdd:pfam07717  76 LLFAPHI 82
DEXHc_DHX34 cd17979
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in ...
 47-102 1.68e-17

DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in the nonsense-mediated decay (NMD), a surveillance mechanism that degrades aberrant mRNAs. DHX34 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350737 [Multi-domain]  Cd Length: 170  Bit Score: 80.56  E-value: 1.68e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907152274  47 IVLDEIHERNLQSDVLMTVIKDLLHFRSDLKVILMSATLNAEKFSEYFGNCPMIHI 102
Cdd:cd17979   115 LILDEVHERHLHGDFLLGVLRCLLRLRPDLKLILMSATINIELFSGYFEGAPVVQV 170
DEXHc_DHX9 cd17972
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ...
 41-102 1.68e-17

DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ATP-dependent RNA helicase A or RHA and leukophysin or LKP) plays an important role in many cellular processes, including regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. DHX9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350730 [Multi-domain]  Cd Length: 234  Bit Score: 82.19  E-value: 1.68e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907152274  41 LSSVSHIVLDEIHERNLQSDVLMTVIKDLLHFRSDLKVILMSATLNAEKFSEYFGNCPMIHI 102
Cdd:cd17972   173 IRGISHVIVDEIHERDINTDFLLVVLRDVVQAYPDLRVILMSATIDTSMFCEYFFNCPVIEV 234
DEXHc_YTHDC2 cd17987
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) ...
 39-102 6.23e-17

DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) regulates mRNA translation and stability via binding to N6-methyladenosine, a modified RNA nucleotide enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. YTHDC2 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350745 [Multi-domain]  Cd Length: 176  Bit Score: 79.10  E-value: 6.23e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907152274  39 ERLSSVSHIVLDEIHERNLQSDVLMTVIKDLLHFRSDLKVILMSATLNAEKFSEYFGNCPMIHI 102
Cdd:cd17987   113 SALSTVTHVIVDEVHERDRFSDFLLTKLRDILQKHPNLKLILSSAALDVNLFIRYFGSCPVIYI 176
DEXHc_DHX38 cd17983
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as ...
 41-102 7.12e-17

DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as PRP16) is involved in pre-mRNA splicing. DHX38 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350741 [Multi-domain]  Cd Length: 173  Bit Score: 79.04  E-value: 7.12e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907152274  41 LSSVSHIVLDEIHERNLQSDVLMTVIKDLLHFRSDLKVILMSATLNAEKFSEYFGNCPMIHI 102
Cdd:cd17983   112 LDKYSAIIMDEAHERSLNTDVLFGLLREVVARRRDLKLIVTSATMDADKFADFFGNVPIFTI 173
DEXHc_DHX16 cd17974
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably ...
 41-102 2.12e-16

DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably involved in pre-mRNA splicing. DHX16 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350732 [Multi-domain]  Cd Length: 174  Bit Score: 77.54  E-value: 2.12e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907152274  41 LSSVSHIVLDEIHERNLQSDVLMTVIKDLLHFRSDLKVILMSATLNAEKFSEYFGNCPMIHI 102
Cdd:cd17974   113 LASYSVMIIDEAHERTLHTDILFGLVKDIARFRPDLKLLISSATMDAEKFSAFFDDAPIFRI 174
DEXHc_DHX33 cd17978
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA ...
 41-102 2.90e-16

DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA polymerase I transcription of the 47S precursor rRNA. DHX33 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438710 [Multi-domain]  Cd Length: 178  Bit Score: 77.39  E-value: 2.90e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907152274  41 LSSVSHIVLDEIHERNLQSDVLMTVIKDLLHFR-----SDLKVILMSATLNAEKFSEYFGNCPMIHI 102
Cdd:cd17978   112 LSKYSVIILDEAHERTVHTDVLFGLVKSAQRRRkeqklSPLKVIIMSATLDADLFSEYFNGAPVLYI 178
DEXHc_DHX40 cd17984
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the ...
 41-102 9.64e-15

DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350742 [Multi-domain]  Cd Length: 178  Bit Score: 72.96  E-value: 9.64e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907152274  41 LSSVSHIVLDEIHERNLQSDVLMTVIKDLLHFRS-----DLKVILMSATLNAEKFSEYFGNCPMIHI 102
Cdd:cd17984   112 LTKYSVIILDEAHERSLTTDILFGLLKKLFQEKSpnrkeHLKVVVMSATLELAKLSAFFGNCPVFDI 178
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
 193-322 1.07e-14

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 70.70  E-value: 1.07e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152274 193 ALIRYIVLEEEDGAILVFLPGWDnistlhdLLMSQVMFKSDKFLIIPLHSLMPTVNQTQVFKKTPPGVRKIVIATNIAET 272
Cdd:pfam00271   4 EALLELLKKERGGKVLIFSQTKK-------TLEAELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAER 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1907152274 273 SITIDDVVYVIdggkiketHFDTQNNISTMsaewvskanaKQRKGRAGRV 322
Cdd:pfam00271  77 GLDLPDVDLVI--------NYDLPWNPASY----------IQRIGRAGRA 108
DEXHc_HrpA cd17989
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA ...
 41-102 1.92e-14

DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpA belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350747 [Multi-domain]  Cd Length: 173  Bit Score: 71.72  E-value: 1.92e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907152274  41 LSSVSHIVLDEIHERNLQSDVLMTVIKDLLHFRSDLKVILMSATLNAEKFSEYFGNCPMIHI 102
Cdd:cd17989   112 LRAYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPDLKVIITSATIDAERFSRHFNNAPIIEV 173
HELICc smart00490
helicase superfamily c-terminal domain;
229-321 7.07e-14

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 67.24  E-value: 7.07e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152274  229 MFKSDKFLIIPLHSLMPTVNQTQVFKKTPPGVRKIVIATNIAETSITIDDVVYVIdggkiketHFDTqnnistmsaeWVS 308
Cdd:smart00490   6 LLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVI--------IYDL----------PWS 67

                           90
                   ....*....|...
gi 1907152274  309 KANAKQRKGRAGR 321
Cdd:smart00490  68 PASYIQRIGRAGR 80
DEXHc_TDRD9 cd17988
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also ...
 41-109 4.86e-12

DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also known as HIG-1or NET54 or C14orf75) is a part of the nuclear PIWI-interacting RNA (piRNA) pathway essential for transposon silencing and male fertility TDRD9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350746 [Multi-domain]  Cd Length: 180  Bit Score: 65.22  E-value: 4.86e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152274  41 LSSVSHIVLDEIHERNLQSDVLMTVIKDLLHFRSD-LKVILMSATLNAEKFSEYFGncpMIHIPGFTFPV 109
Cdd:cd17988   114 LTEYTHIILDEVHERDQELDFLLLVVRRLLRTNSRhVKIILMSATISCKEFADYFT---TPNNPAYVFEV 180
DEXHc_HrpB cd17990
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ...
 41-100 7.15e-12

DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438711 [Multi-domain]  Cd Length: 174  Bit Score: 64.28  E-value: 7.15e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907152274  41 LSSVSHIVLDEIHERNLQSDVLMTVIKDLLH-FRSDLKVILMSATLNAEKFSEYFGNCPMI 100
Cdd:cd17990   112 LSGVGAVILDEFHERSLDADLALALLLEVQQlLRDDLRLLAMSATLDGDGLAALLPEAPVV 172
PHA02653 PHA02653
RNA helicase NPH-II; Provisional
 37-325 9.66e-12

RNA helicase NPH-II; Provisional


Pssm-ID: 177443 [Multi-domain]  Cd Length: 675  Bit Score: 68.47  E-value: 9.66e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152274  37 TRERLSSVSHIVLDEIHERNLQSDVLMTVI-KDLLHFRSdlkVILMSATL--NAEKFSEYFGNCPMIHIPGFT-FPVVEy 112
Cdd:PHA02653  285 TLNKLFDYGTVIIDEVHEHDQIGDIIIAVArKHIDKIRS---LFLMTATLedDRDRIKEFFPNPAFVHIPGGTlFPISE- 360

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152274 113 lledIIEKIRYVPDQKehrsqfkrgfmqghvnRQEKEEkeaiykerwpayikELRtrysastvdvlqmmdddkvdlNLIA 192
Cdd:PHA02653  361 ----VYVKNKYNPKNK----------------RAYIEE--------------EKK---------------------NIVT 385

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152274 193 ALIRYIVLEEEDGaiLVFLPgwdNISTLHDL--LMSQvMFKSDKFLIIplHSLMPTVNQ--TQVFKKTPPgvrKIVIATN 268
Cdd:PHA02653  386 ALKKYTPPKGSSG--IVFVA---SVSQCEEYkkYLEK-RLPIYDFYII--HGKVPNIDEilEKVYSSKNP---SIIISTP 454

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1907152274 269 IAETSITIDDVVYVIDGGKIKETHFDTQNNIstmsaeWVSKANAKQRKGRAGRVQPG 325
Cdd:PHA02653  455 YLESSVTIRNATHVYDTGRVYVPEPFGGKEM------FISKSMRTQRKGRVGRVSPG 505
DEXHc_DHX35 cd17980
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and ...
 41-94 2.75e-11

DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and seems to be associated with risk to thyroid cancers. It also has been shown to positively regulate poxviruses, such as Myxoma virus. DEAH-box helicase 35 (DHX35) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350738 [Multi-domain]  Cd Length: 185  Bit Score: 62.87  E-value: 2.75e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1907152274  41 LSSVSHIVLDEIHERNLQSDVLMTVIKDLLHFRSDLKVILMSATLNAEKFSEYF 94
Cdd:cd17980   114 LTKYSVIMLDEAHERTLYTDILIGLLKKIQKKRGDLRLIVASATLDAEKFRDFF 167
DEXHc_DHX32 cd17977
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the ...
 41-102 2.44e-09

DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350735 [Multi-domain]  Cd Length: 176  Bit Score: 57.14  E-value: 2.44e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907152274  41 LSSVSHIVLDEIHERNLQSDVLMTVIKDLLHFRSDLKVILMSATLNAEKFSEYFGNCPMIHI 102
Cdd:cd17977   115 LESYGVIILDDAHERTVSTDVLLGLLKDVLLSRPELKLVIITCPHLSSKLLSYYGNVPLIEV 176
DEXHc_DHX37 cd17982
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the ...
 41-92 5.56e-07

DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the human nervous system and has been linked to schizophrenia. It also negatively regulates poxviruses such as Myxoma virus. DEAH-box helicase 37 (DHX37) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350740 [Multi-domain]  Cd Length: 191  Bit Score: 50.43  E-value: 5.56e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907152274  41 LSSVSHIVLDEIHERNLQSDVLMTVIKDLLHFRSD----------LKVILMSATLNAEKFSE 92
Cdd:cd17982   116 LRKYSVIIIDEAHERSVNTDILIGMLSRIVPLRAKlylqdqtvkpLKLVIMSATLRVEDFTE 177
DEXDc smart00487
DEAD-like helicases superfamily;
38-108 6.04e-07

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 50.57  E-value: 6.04e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907152274   38 RERLSSVSHIVLDEIHER--NLQSDVLMTVIKDLlhfRSDLKVILMSATL--NAEKFSEYFGNCPMIHIPGFTFP 108
Cdd:smart00487 124 KLSLSNVDLVILDEAHRLldGGFGDQLEKLLKLL---PKNVQLLLLSATPpeEIENLLELFLNDPVFIDVGFTPL 195
DEXQc_DQX1 cd17986
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 ...
 47-102 7.65e-07

DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 (DQX1) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350744 [Multi-domain]  Cd Length: 177  Bit Score: 49.90  E-value: 7.65e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907152274  47 IVLDEIHERNLQSDVLMTVIKDLLHFRSDLKVILMSATLNAEKFSEYFGNCPMIHI 102
Cdd:cd17986   122 VVLDEAQERSVASDSLLGLLKDVRLQRPELRVVVVTSPALEPKLRAFWGNPPVVHV 177
DEXHc_Ski2 cd17921
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ...
 41-103 4.81e-04

DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350679 [Multi-domain]  Cd Length: 181  Bit Score: 41.86  E-value: 4.81e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907152274  41 LSSVSHIVLDEIHERNLQS--DVLMTVIKDLLHFRSDLKVILMSATL-NAEKFSEYFGNCPMIHIP 103
Cdd:cd17921   116 IQDVRLVVVDEAHLIGDGErgVVLELLLSRLLRINKNARFVGLSATLpNAEDLAEWLGVEDLIRFD 181
DEAD pfam00270
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ...
 38-88 8.97e-04

DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.


Pssm-ID: 425570 [Multi-domain]  Cd Length: 165  Bit Score: 40.69  E-value: 8.97e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1907152274  38 RERLSSVSHIVLDEIHE--RNLQSDVLMTVIKdllHFRSDLKVILMSATLNAE 88
Cdd:pfam00270 112 RKLLKNLKLLVLDEAHRllDMGFGPDLEEILR---RLPKKRQILLLSATLPRN 161
SF2_C cd18785
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ...
 262-321 9.77e-03

C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350172 [Multi-domain]  Cd Length: 77  Bit Score: 35.76  E-value: 9.77e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152274 262 KIVIATNIAETSITIDDVVYVIdggkiketHFDtqnnistmsaEWVSKANAKQRKGRAGR 321
Cdd:cd18785    24 EILVATNVLGEGIDVPSLDTVI--------FFD----------PPSSAASYIQRVGRAGR 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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