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Conserved domains on  [gi|1907152680|ref|XP_036019328|]
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WD repeat-containing protein 47 isoform X4 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
663-972 2.45e-53

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 191.66  E-value: 2.45e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152680 663 TQAVRAVAFHPSGSLYAVGSNSKTLRVcaypekMDASAHDNPKQPvvrfkrnKHHKGSIYCVAWSPCGQLLATGSNDKYV 742
Cdd:COG2319    78 TAAVLSVAFSPDGRLLASASADGTVRL------WDLATGLLLRTL-------TGHTGAVRSVAFSPDGKTLASGSADGTV 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152680 743 KVlpFNAetcnATGPDL-EFSMHDGTIRDLAFmegpeSG-GAILISAGAgDCNIYTTDCQRGQGLHALSGHTGHILALyT 820
Cdd:COG2319   145 RL--WDL----ATGKLLrTLTGHSGAVTSVAF-----SPdGKLLASGSD-DGTVRLWDLATGKLLRTLTGHTGAVRSV-A 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152680 821 WS--GWMIASGSQDKTVRFWDLRVPSCVRvvgtTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPH 898
Cdd:COG2319   212 FSpdGKLLASGSADGTVRLWDLATGKLLR----TLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGH 287

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907152680 899 SSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQ-GDLTKQLPlmvvgEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 972
Cdd:COG2319   288 SGGVNSVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLT-----GHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
CTLH smart00668
C-terminal to LisH motif; Alpha-helical motif of unknown function.
 95-152 8.17e-13

C-terminal to LisH motif; Alpha-helical motif of unknown function.


:

Pssm-ID: 128914  Cd Length: 58  Bit Score: 63.74  E-value: 8.17e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1907152680   95 FSDDMLFLRQLILDGQWDEVLQFIQPLECMEKFDKKRFRYIILKQKFLEALCVNNAMS 152
Cdd:smart00668   1 EFDERKRIRELILKGDWDEALEWLSSLKPPLLERNSKLEFELRKQKFLELVRQGKLEE 58
LisH_TPL super family cl39307
LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal ...
 63-90 2.25e-05

LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal domain containing a lissencephaly homologous (LisH) dimerization motif.


The actual alignment was detected with superfamily member pfam17814:

Pssm-ID: 375350  Cd Length: 30  Bit Score: 41.99  E-value: 2.25e-05
                          10        20
                  ....*....|....*....|....*...
gi 1907152680  63 EIIKLILDFLNSKKLHISMLALEKESGV 90
Cdd:pfam17814   3 DVVRLILQFLKENGLHRTLQALQTESGV 30
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
663-972 2.45e-53

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 191.66  E-value: 2.45e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152680 663 TQAVRAVAFHPSGSLYAVGSNSKTLRVcaypekMDASAHDNPKQPvvrfkrnKHHKGSIYCVAWSPCGQLLATGSNDKYV 742
Cdd:COG2319    78 TAAVLSVAFSPDGRLLASASADGTVRL------WDLATGLLLRTL-------TGHTGAVRSVAFSPDGKTLASGSADGTV 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152680 743 KVlpFNAetcnATGPDL-EFSMHDGTIRDLAFmegpeSG-GAILISAGAgDCNIYTTDCQRGQGLHALSGHTGHILALyT 820
Cdd:COG2319   145 RL--WDL----ATGKLLrTLTGHSGAVTSVAF-----SPdGKLLASGSD-DGTVRLWDLATGKLLRTLTGHTGAVRSV-A 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152680 821 WS--GWMIASGSQDKTVRFWDLRVPSCVRvvgtTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPH 898
Cdd:COG2319   212 FSpdGKLLASGSADGTVRLWDLATGKLLR----TLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGH 287

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907152680 899 SSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQ-GDLTKQLPlmvvgEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 972
Cdd:COG2319   288 SGGVNSVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLT-----GHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 656-972 4.29e-51

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 181.76  E-value: 4.29e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152680 656 CINTLED-TQAVRAVAFHPSGSLYAVGSNSKTLRVCAYpekmdasahdnpkQPVVRFKRNKHHKGSIYCVAWSPCGQLLA 734
Cdd:cd00200     1 LRRTLKGhTGGVTCVAFSPDGKLLATGSGDGTIKVWDL-------------ETGELLRTLKGHTGPVRDVAASADGTYLA 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152680 735 TGSNDKYVKVLPFNAETCNATgpdleFSMHDGTIRDLAFMEGPEsggaiLISAGAGDCNIYTTDCQRGQGLHALSGHTGH 814
Cdd:cd00200    68 SGSSDKTIRLWDLETGECVRT-----LTGHTSYVSSVAFSPDGR-----ILSSSSRDKTIKVWDVETGKCLTTLRGHTDW 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152680 815 ILAL-YTWSGWMIASGSQDKTVRFWDLRVPSCVRvvgtTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQ 893
Cdd:cd00200   138 VNSVaFSPDGTFVASSSQDGTIKLWDLRTGKCVA----TLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLG 213

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907152680 894 SYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQgdltKQLPLMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 972
Cdd:cd00200   214 TLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLR----TGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
CTLH smart00668
C-terminal to LisH motif; Alpha-helical motif of unknown function.
 95-152 8.17e-13

C-terminal to LisH motif; Alpha-helical motif of unknown function.


Pssm-ID: 128914  Cd Length: 58  Bit Score: 63.74  E-value: 8.17e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1907152680   95 FSDDMLFLRQLILDGQWDEVLQFIQPLECMEKFDKKRFRYIILKQKFLEALCVNNAMS 152
Cdd:smart00668   1 EFDERKRIRELILKGDWDEALEWLSSLKPPLLERNSKLEFELRKQKFLELVRQGKLEE 58
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 715-744 2.04e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.08  E-value: 2.04e-07
                           10        20        30
                   ....*....|....*....|....*....|
gi 1907152680  715 KHHKGSIYCVAWSPCGQLLATGSNDKYVKV 744
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKL 38
WD40 pfam00400
WD domain, G-beta repeat;
715-744 1.82e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.41  E-value: 1.82e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 1907152680 715 KHHKGSIYCVAWSPCGQLLATGSNDKYVKV 744
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKV 37
LisH_TPL pfam17814
LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal ...
 63-90 2.25e-05

LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal domain containing a lissencephaly homologous (LisH) dimerization motif.


Pssm-ID: 375350  Cd Length: 30  Bit Score: 41.99  E-value: 2.25e-05
                          10        20
                  ....*....|....*....|....*...
gi 1907152680  63 EIIKLILDFLNSKKLHISMLALEKESGV 90
Cdd:pfam17814   3 DVVRLILQFLKENGLHRTLQALQTESGV 30
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 821-975 1.87e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.46  E-value: 1.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152680 821 WSGWM---IASGSQDKTVRFWDLRVPSCVrvvgTTFHGTGSAVASV---AVDPSgrLLATGQEDSSCMLYDIRGGRMVQS 894
Cdd:PLN00181  540 WNSYIksqVASSNFEGVVQVWDVARSQLV----TEMKEHEKRVWSIdysSADPT--LLASGSDDGSVKLWSINQGVSIGT 613

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152680 895 YHPhSSDVRSVRF-SPGAHYLLTGSYDMKIKVTDLQgdlTKQLPLMVVGEHKDKVIQCRWhTQDLSFLSSSADRTVTLWT 973
Cdd:PLN00181  614 IKT-KANICCVQFpSESGRSLAFGSADHKVYYYDLR---NPKLPLCTMIGHSKTVSYVRF-VDSSTLVSSSTDNTLKLWD 688


                  ..
gi 1907152680 974 YS 975
Cdd:PLN00181  689 LS 690
LisH smart00667
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
 59-92 3.20e-03

Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.


Pssm-ID: 128913  Cd Length: 34  Bit Score: 35.87  E-value: 3.20e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907152680   59 VKEVEIIKLILDFLNSKKLHISMLALEKESGVIN 92
Cdd:smart00667   1 ISRSELNRLILEYLLRNGYEETAETLQKESGLSL 34
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
663-972 2.45e-53

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 191.66  E-value: 2.45e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152680 663 TQAVRAVAFHPSGSLYAVGSNSKTLRVcaypekMDASAHDNPKQPvvrfkrnKHHKGSIYCVAWSPCGQLLATGSNDKYV 742
Cdd:COG2319    78 TAAVLSVAFSPDGRLLASASADGTVRL------WDLATGLLLRTL-------TGHTGAVRSVAFSPDGKTLASGSADGTV 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152680 743 KVlpFNAetcnATGPDL-EFSMHDGTIRDLAFmegpeSG-GAILISAGAgDCNIYTTDCQRGQGLHALSGHTGHILALyT 820
Cdd:COG2319   145 RL--WDL----ATGKLLrTLTGHSGAVTSVAF-----SPdGKLLASGSD-DGTVRLWDLATGKLLRTLTGHTGAVRSV-A 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152680 821 WS--GWMIASGSQDKTVRFWDLRVPSCVRvvgtTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPH 898
Cdd:COG2319   212 FSpdGKLLASGSADGTVRLWDLATGKLLR----TLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGH 287

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907152680 899 SSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQ-GDLTKQLPlmvvgEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 972
Cdd:COG2319   288 SGGVNSVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLT-----GHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 COG2319
WD40 repeat [General function prediction only];
663-972 1.06e-52

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 190.12  E-value: 1.06e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152680 663 TQAVRAVAFHPSGSLYAVGSNSKTLRVcaypekMDASAhdnpKQPVVRFKrnkHHKGSIYCVAWSPCGQLLATGSNDKYV 742
Cdd:COG2319   120 TGAVRSVAFSPDGKTLASGSADGTVRL------WDLAT----GKLLRTLT---GHSGAVTSVAFSPDGKLLASGSDDGTV 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152680 743 KVlpFNAetcnATGPDL-EFSMHDGTIRDLAFmeGPEsgGAILISAGAgDCNIYTTDCQRGQGLHALSGHTGHILALyTW 821
Cdd:COG2319   187 RL--WDL----ATGKLLrTLTGHTGAVRSVAF--SPD--GKLLASGSA-DGTVRLWDLATGKLLRTLTGHSGSVRSV-AF 254

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152680 822 S--GWMIASGSQDKTVRFWDLRVPSCVRvvgtTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHS 899
Cdd:COG2319   255 SpdGRLLASGSADGTVRLWDLATGELLR----TLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHT 330

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907152680 900 SDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGdltkQLPLMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 972
Cdd:COG2319   331 GAVRSVAFSPDGKTLASGSDDGTVRLWDLAT----GELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 656-972 4.29e-51

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 181.76  E-value: 4.29e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152680 656 CINTLED-TQAVRAVAFHPSGSLYAVGSNSKTLRVCAYpekmdasahdnpkQPVVRFKRNKHHKGSIYCVAWSPCGQLLA 734
Cdd:cd00200     1 LRRTLKGhTGGVTCVAFSPDGKLLATGSGDGTIKVWDL-------------ETGELLRTLKGHTGPVRDVAASADGTYLA 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152680 735 TGSNDKYVKVLPFNAETCNATgpdleFSMHDGTIRDLAFMEGPEsggaiLISAGAGDCNIYTTDCQRGQGLHALSGHTGH 814
Cdd:cd00200    68 SGSSDKTIRLWDLETGECVRT-----LTGHTSYVSSVAFSPDGR-----ILSSSSRDKTIKVWDVETGKCLTTLRGHTDW 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152680 815 ILAL-YTWSGWMIASGSQDKTVRFWDLRVPSCVRvvgtTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQ 893
Cdd:cd00200   138 VNSVaFSPDGTFVASSSQDGTIKLWDLRTGKCVA----TLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLG 213

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907152680 894 SYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQgdltKQLPLMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 972
Cdd:cd00200   214 TLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLR----TGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
656-930 6.60e-48

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 176.26  E-value: 6.60e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152680 656 CINTLED-TQAVRAVAFHPSGSLYAVGSNSKTLRVCaypekmDASAHdnpkQPVVRFKrnkHHKGSIYCVAWSPCGQLLA 734
Cdd:COG2319   154 LLRTLTGhSGAVTSVAFSPDGKLLASGSDDGTVRLW------DLATG----KLLRTLT---GHTGAVRSVAFSPDGKLLA 220

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152680 735 TGSNDKYVKVlpFNAETCNATGPdleFSMHDGTIRDLAFMegpeSGGAILISAGAgDCNIYTTDCQRGQGLHALSGHTGH 814
Cdd:COG2319   221 SGSADGTVRL--WDLATGKLLRT---LTGHSGSVRSVAFS----PDGRLLASGSA-DGTVRLWDLATGELLRTLTGHSGG 290

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152680 815 ILALyTWS--GWMIASGSQDKTVRFWDLRVPSCVRvvgtTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMV 892
Cdd:COG2319   291 VNSV-AFSpdGKLLASGSDDGTVRLWDLATGKLLR----TLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELL 365

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1907152680 893 QSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQG 930
Cdd:COG2319   366 RTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 656-885 1.72e-33

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 130.92  E-value: 1.72e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152680 656 CINTLED-TQAVRAVAFHPSGSLYAVGSNSKTLRVcaypekmdasaHDNPK-QPVVRFKrnkHHKGSIYCVAWSPCGQLL 733
Cdd:cd00200    85 CVRTLTGhTSYVSSVAFSPDGRILSSSSRDKTIKV-----------WDVETgKCLTTLR---GHTDWVNSVAFSPDGTFV 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152680 734 ATGSNDKYVKVLPFNAETCNATgpdleFSMHDGTIRDLAFMEgpeSGGAILISAGAGDCNIYttDCQRGQGLHALSGHTG 813
Cdd:cd00200   151 ASSSQDGTIKLWDLRTGKCVAT-----LTGHTGEVNSVAFSP---DGEKLLSSSSDGTIKLW--DLSTGKCLGTLRGHEN 220

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907152680 814 HILAL-YTWSGWMIASGSQDKTVRFWDLRVPSCVRvvgtTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYD 885
Cdd:cd00200   221 GVNSVaFSPDGYLLASGSEDGTIRVWDLRTGECVQ----TLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 653-839 1.74e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 98.95  E-value: 1.74e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152680 653 QFVCINTLED-TQAVRAVAFHPSGSLYAVGSNSKTLRVCaypekmDASAHdnpkQPVVRFKrnkHHKGSIYCVAWSPCGQ 731
Cdd:cd00200   124 TGKCLTTLRGhTDWVNSVAFSPDGTFVASSSQDGTIKLW------DLRTG----KCVATLT---GHTGEVNSVAFSPDGE 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152680 732 LLATGSNDKYVKVLPFNAETCNATgpdleFSMHDGTIRDLAFMEGPEsggaiLISAGAGDCNIYTTDCQRGQGLHALSGH 811
Cdd:cd00200   191 KLLSSSSDGTIKLWDLSTGKCLGT-----LRGHENGVNSVAFSPDGY-----LLASGSEDGTIRVWDLRTGECVQTLSGH 260

                         170       180       190
                  ....*....|....*....|....*....|
gi 1907152680 812 TGHILALyTWS--GWMIASGSQDKTVRFWD 839
Cdd:cd00200   261 TNSVTSL-AWSpdGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
779-972 1.10e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 89.59  E-value: 1.10e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152680 779 SGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILAL-YTWSGWMIASGSQDKTVRFWDLRVPSCVRvvgtTFHGTG 857
Cdd:COG2319     3 SADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLaASPDGARLAAGAGDLTLLLLDAAAGALLA----TLLGHT 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152680 858 SAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQ-GDLTKQL 936
Cdd:COG2319    79 AAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAtGKLLRTL 158

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1907152680 937 PlmvvgEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 972
Cdd:COG2319   159 T-----GHSGAVTSVAFSPDGKLLASGSDDGTVRLW 189
CTLH smart00668
C-terminal to LisH motif; Alpha-helical motif of unknown function.
 95-152 8.17e-13

C-terminal to LisH motif; Alpha-helical motif of unknown function.


Pssm-ID: 128914  Cd Length: 58  Bit Score: 63.74  E-value: 8.17e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1907152680   95 FSDDMLFLRQLILDGQWDEVLQFIQPLECMEKFDKKRFRYIILKQKFLEALCVNNAMS 152
Cdd:smart00668   1 EFDERKRIRELILKGDWDEALEWLSSLKPPLLERNSKLEFELRKQKFLELVRQGKLEE 58
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 898-976 8.48e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 63.89  E-value: 8.48e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907152680 898 HSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLtkqlPLMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLWTYSG 976
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGE----LLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET 82
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 715-744 2.04e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.08  E-value: 2.04e-07
                           10        20        30
                   ....*....|....*....|....*....|
gi 1907152680  715 KHHKGSIYCVAWSPCGQLLATGSNDKYVKV 744
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKL 38
WD40 pfam00400
WD domain, G-beta repeat;
715-744 1.82e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.41  E-value: 1.82e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 1907152680 715 KHHKGSIYCVAWSPCGQLLATGSNDKYVKV 744
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKV 37
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 889-927 2.77e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 2.77e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1907152680  889 GRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTD 927
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
889-927 9.67e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 9.67e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1907152680 889 GRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTD 927
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 802-839 1.72e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 1.72e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1907152680  802 GQGLHALSGHTGHILALyTWS--GWMIASGSQDKTVRFWD 839
Cdd:smart00320   2 GELLKTLKGHTGPVTSV-AFSpdGKYLASGSDDGTIKLWD 40
LisH_TPL pfam17814
LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal ...
 63-90 2.25e-05

LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal domain containing a lissencephaly homologous (LisH) dimerization motif.


Pssm-ID: 375350  Cd Length: 30  Bit Score: 41.99  E-value: 2.25e-05
                          10        20
                  ....*....|....*....|....*...
gi 1907152680  63 EIIKLILDFLNSKKLHISMLALEKESGV 90
Cdd:pfam17814   3 DVVRLILQFLKENGLHRTLQALQTESGV 30
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 821-975 1.87e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.46  E-value: 1.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152680 821 WSGWM---IASGSQDKTVRFWDLRVPSCVrvvgTTFHGTGSAVASV---AVDPSgrLLATGQEDSSCMLYDIRGGRMVQS 894
Cdd:PLN00181  540 WNSYIksqVASSNFEGVVQVWDVARSQLV----TEMKEHEKRVWSIdysSADPT--LLASGSDDGSVKLWSINQGVSIGT 613

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152680 895 YHPhSSDVRSVRF-SPGAHYLLTGSYDMKIKVTDLQgdlTKQLPLMVVGEHKDKVIQCRWhTQDLSFLSSSADRTVTLWT 973
Cdd:PLN00181  614 IKT-KANICCVQFpSESGRSLAFGSADHKVYYYDLR---NPKLPLCTMIGHSKTVSYVRF-VDSSTLVSSSTDNTLKLWD 688


                  ..
gi 1907152680 974 YS 975
Cdd:PLN00181  689 LS 690
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 847-902 7.92e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 39.57  E-value: 7.92e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907152680 847 RVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDV 902
Cdd:pfam12894  28 RVWTLSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLI 83
WD40 pfam00400
WD domain, G-beta repeat;
805-839 1.04e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 1.04e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1907152680 805 LHALSGHTGHILAL-YTWSGWMIASGSQDKTVRFWD 839
Cdd:pfam00400   4 LKTLEGHTGSVTSLaFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 852-885 1.54e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 1.54e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907152680  852 TFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYD 885
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
851-885 2.22e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 2.22e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1907152680 851 TTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYD 885
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
LisH smart00667
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
 59-92 3.20e-03

Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.


Pssm-ID: 128913  Cd Length: 34  Bit Score: 35.87  E-value: 3.20e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907152680   59 VKEVEIIKLILDFLNSKKLHISMLALEKESGVIN 92
Cdd:smart00667   1 ISRSELNRLILEYLLRNGYEETAETLQKESGLSL 34
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 653-689 3.45e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.14  E-value: 3.45e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1907152680  653 QFVCINTLED-TQAVRAVAFHPSGSLYAVGSNSKTLRV 689
Cdd:smart00320   1 SGELLKTLKGhTGPVTSVAFSPDGKYLASGSDDGTIKL 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 937-972 6.61e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 6.61e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907152680  937 PLMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 972
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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