|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MFSD14 |
cd17387 |
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of ... |
48-461 |
0e+00 |
|
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of major facilitator superfamily domain-containing 14A (MFSD14A) and MFSD14B, and similar proteins. MFSD14A and MFSD14B are also called hippocampus abundant transcript 1 protein (HIAT1) and hippocampus abundant transcript-like protein 1 (HIATL1), respectively. They are both ubiquitously expressed with HIAT1 highly expressed intestis and HIATL1 most abundantly expressed in skeletal muscle. Gene disruption of MFSD14A causes globozoospermia and infertility in male mice. It has bee suggested that MFSD14A may transport a solute from the bloodstream that is required for spermiogenesis. The function of MFSD14B is unknown. The MFSD14 subfamily belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340945 [Multi-domain] Cd Length: 410 Bit Score: 745.01 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 48 VYHAVVVIFLEFFAWGLLTTPMLTVLHQTFPQHTFLMNGLIHGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPI 127
Cdd:cd17387 1 VYHAVVVIFLEFFAWGLLTTPMITVLHETFPQHTFLMNGLVQGVKGILSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 128 PLMRISPWWYFAVISMSGVFAVTFSVIFAYVADITQEHERSTAYGLVSATFAASLVTSPAIGAYLSRAYGDTLVVILATA 207
Cdd:cd17387 81 PLMRISPWWYFAMISVSGIFSVTFSVIFAYVADITTEEERSTAYGLVSATFAASLVTSPALGAYLSESYGDNLVVLVATI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 208 IALLDICFILVAVPESLPEKMRPASWGAPISWEQADPFASLRKVGQDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIG 287
Cdd:cd17387 161 VALLDICFILLAVPESLPEKMRPASWGAPISWEQADPFASLRKVGKDKTVLLICITVFLSYLPEAGQYSSFFVYLKQVMG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 288 FTSETVAAFIAVVGILSILAQTVVLGILMRSIGNKNTILLGLGFQILQLAWYGFGSQPWMMWAAGAVAAMSSITFPAISA 367
Cdd:cd17387 241 FEYEEVAAFIAVVGILSITAQTLLLSILMRSIGAKNTILLGLGFQMLQLAWYGFGSQHWMMWAAGAVAAMSSITFPAISA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 368 IVSRNADPDQQGVVQGMITGIRGLCNGLGPALYGFVFYLFHVELNEMDAVESpdkdTKPNMANPTDESAIIPGPPFLFGA 447
Cdd:cd17387 321 LVSRYADPDQQGAVQGMITGIRGLCNGLGPALFGFVFYLFHVDLNEIKPVQS----SKQRMQNPSLEGAIIPGPPFLFGA 396
|
410
....*....|....
gi 1916914340 448 CSVLLSLLVALFIP 461
Cdd:cd17387 397 ISVLLAILVASFIP 410
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
53-407 |
6.52e-71 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 229.77 E-value: 6.52e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 53 VVIFLEFFAWGLLTTPMLTVLHQT-FPQHTFLMNGLIHGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMR 131
Cdd:cd17330 3 LVVFLDALGFGIVFPVLPFYVREFnKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 132 ISP--WWYFAVISMSGVFAVTFSVIFAYVADITQEHERSTAYGLVSATFAASLVTSPAIGAYLSRAYGDTLVVILATAIA 209
Cdd:cd17330 83 LSRnlWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 210 LLDICFILVAVPeslpekmrpaswgapisweqadpfaslrkvgqdsTVLLICITVFLSYLPEAGQYSSFFLYLRQVIGFT 289
Cdd:cd17330 163 LLNLVLVLFFLP----------------------------------PLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFS 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 290 SETVAAFIAVVGILSILAQTVVLGILMRSIGNKNTILLGLGFQILQLAWYGFGS-QPWMMWAAGAVAAMSSITFPAISAI 368
Cdd:cd17330 209 PSQIGLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASsVPLLVLAAAILAFGTGIVFPALSAL 288
|
330 340 350
....*....|....*....|....*....|....*....
gi 1916914340 369 VSRNADPDQQGVVQGMITGIRGLCNGLGPALYGFVFYLF 407
Cdd:cd17330 289 LSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFL 327
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
93-407 |
3.39e-44 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 160.11 E-value: 3.39e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 93 GLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMRISP--WWYFAVISMSGVFAVTFSVIFAYVADITQEHERSTA 170
Cdd:cd17388 48 ALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYLLMAFAPtlWWLYLGRIIAGITGATGAVAAAYIADVTPPEQRARN 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 171 YGLVSATFAASLVTSPAIGAYLSrAYGDTLVVILATAIALLDICFILVAVPESLPEKMRPASwgapiSWEQADPFASLRK 250
Cdd:cd17388 128 FGLLGAAFGLGFIAGPALGGLLG-EISPRAPFLVAAGLNGLNFLLGLFVLPESLPPERRRAF-----RWRRANPFGSLRW 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 251 VGQDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIGFTSETVAAFIAVVGILSILAQTVVLGILMRSIGNKNTILLGLG 330
Cdd:cd17388 202 LTGFPGLLGLLAVFFLIQLIGQVPATTWVLFTEDRFDWSPTMVGLSLAVFGLLHALFQAFVTGPIAKRLGEKRAILLGLA 281
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1916914340 331 FQILQLAWYGFGSQPWMMWAAGAVAAMSSITFPAISAIVSRNADPDQQGVVQGMITGIRGLCNGLGPALYGFVFYLF 407
Cdd:cd17388 282 ADALGFLLLAFATQGWMVFPILILLALGGIAGPALQGLLSRQVPENEQGELQGVLTSLTSLTSIIGPLLFTGIFAAS 358
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
53-408 |
8.90e-35 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 133.86 E-value: 8.90e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 53 VVIFLEFFAWGLLTtPMLTVLHQTFPQHTFLMnGLIHGVKGLLSFLSAPLIGALSDVWGRKSFLLL-TVFFTCAPIPLMR 131
Cdd:cd17325 3 LALFLDMLGYGIII-PILPLYAESLGASVAQI-GLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLgLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 132 ISPWWYFAVISM-SGVF-AVTFSVIFAYVADITQEHERSTAYGLVSATFAASLVTSPAIGAYLSRAYGDTLVVILATAIA 209
Cdd:cd17325 81 ATSYWQLLLARFlQGLAsAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 210 LLDICFILVAVPESLPEKmrpaswgAPISWEQADPFASLRKVGQDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIGFT 289
Cdd:cd17325 161 LLALVLALLLLPEPRPPP-------NKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLS 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 290 SETVAAFIAVVGILSILAQtVVLGILMRSIGNKNTILLGLGFQILQLAWYGFGSQPWMMWAAGAVA-AMSSITFPAISAI 368
Cdd:cd17325 234 PAQIGLLFGAQGLASALSQ-PPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLgLGLGLVFPATLAL 312
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1916914340 369 VSRNADPDQQGVVQGMITGIRGLCNGLGPALYGFVFYLFH 408
Cdd:cd17325 313 LADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFG 352
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
52-395 |
1.90e-31 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 124.32 E-value: 1.90e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 52 VVVIFLEFFAWGLLTtPMLTVLHQTFpQHTFLMNGLIHGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMR 131
Cdd:COG2814 16 ALGAFLSGLGIGIVL-PALPLIAADL-GASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 132 ISP--WWYFAVISMSGVF-AVTFSVIFAYVADITQEHERSTAYGLVSATFAASLVTSPAIGAYLSRAYGDTLVVILATAI 208
Cdd:COG2814 94 LAPslWLLLAARFLQGLGaGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 209 ALLDICFILVAVPESLPEKMRPASwgapisweqadpfASLRKVGQDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIGF 288
Cdd:COG2814 174 ALLALLLLLRLLPESRPAARARLR-------------GSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 289 TSETVAAFIAVVGILSILAQtVVLGILMRSIGNKNTILLGLGFQILQLAWYGFGSQPWMMWAAGAVAAMS-SITFPAISA 367
Cdd:COG2814 241 SASAAGLLLALFGLGGVLGA-LLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGfGLLFPLLQA 319
|
330 340
....*....|....*....|....*...
gi 1916914340 368 IVSRNADPDQQGVVQGMITGIRGLCNGL 395
Cdd:COG2814 320 LVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
86-407 |
6.18e-28 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 114.63 E-value: 6.18e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 86 GLIHGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMRI--SPWWYFAVISMSGVF-AVTFSVIFAYVADIT 162
Cdd:cd17329 38 GLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFahSPWLFAIALVLTGFGgGLFEPASEAMIADVT 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 163 QEHERSTAYGLVSATFAASLVTSPAIGAYLSRaYGDTLVVILATAIALLDICFILVAVPESLPEKMRPaswgapiswEQA 242
Cdd:cd17329 118 TPENRTRAFSLLYWAINLGVAIGPLLGGLLLL-YSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAA---------EKT 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 243 DPFASLRKVGQDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIGFTSETVAAFIAVVGILSILAQTVVLGiLMRSIGNK 322
Cdd:cd17329 188 EILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVAR-LVERFRLR 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 323 NTILLGLGFQILQLAWYGFGSQPWMMWAAGAVAAM-SSITFPAISAIVSRNADPDQQGVVQGMITGIRGLCNGLGPALYG 401
Cdd:cd17329 267 KILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLgEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGG 346
|
....*.
gi 1916914340 402 FVFYLF 407
Cdd:cd17329 347 LLLDLL 352
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
53-397 |
3.48e-26 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 109.04 E-value: 3.48e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 53 VVIFLEFFAWGLLTTPMLTVLHQTFpQHTFLMNGLIHGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAP--IPLM 130
Cdd:pfam07690 3 LAAFLAALGRSLLGPALPLLLAEDL-GISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGllLLLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 131 RISPWWYFAVISMSGVF-AVTFSVIFAYVADITQEHERSTAYGLVSATFAASLVTSPAIGAYLSRAYGDTLVVILATAIA 209
Cdd:pfam07690 82 ASSLWLLLVLRVLQGLGaGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILS 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 210 LldICFILVAVPESLPEKMRPASWGApISWEQADPFASLRKVGQDSTVLLICITVFLSYLpeagqYSSFFLYLRQVIGFT 289
Cdd:pfam07690 162 L--LAAVLLLLPRPPPESKRPKPAEE-ARLSLIVAWKALLRDPVLWLLLALLLFGFAFFG-----LLTYLPLYQEVLGLS 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 290 SETVAAFIAVVGILSILAQtVVLGILMRSIGNKNTILLGLGFQIL---QLAWYGFGSQPWMMWAAGAVAAMS-SITFPAI 365
Cdd:pfam07690 234 ALLAGLLLGLGGLLGAIGR-LLLGRLSDRLGRRRRLLLALLLLILaalGLLLLSLTLSSLWLLLALLLLGFGfGLVFPAL 312
|
330 340 350
....*....|....*....|....*....|..
gi 1916914340 366 SAIVSRNADPDQQGVVQGMITGIRGLCNGLGP 397
Cdd:pfam07690 313 NALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
51-408 |
3.90e-26 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 109.82 E-value: 3.90e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 51 AVVVIFLEFFAWGLLTTPMLTVLHQTfpQHTFLMNGLIHGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLM 130
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSF--GLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 131 RISP--WWYFAVISMSGVF-AVTFSVIFAYVADITQEHERSTAYGLVSATFAASLVTSPAIGAYLSRAYGDTLVVILATA 207
Cdd:cd06174 79 AFAPsfWLLLLGRFLLGLGsGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 208 IALLDICFIL-VAVPESLPEKMRPaswgAPISWEQADPFASLRKVGQDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVI 286
Cdd:cd06174 159 AALALLAAILlLLVVPDPPESARA----KNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 287 GFTSETVAAFIAVVGILSILAQTVVLGILMRSIGNKNTILLGLGFQILQLAWYGFGSQPWMMWAAGA-VAAMSSITFPAI 365
Cdd:cd06174 235 GLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLlLGFGLGGLLPLS 314
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 1916914340 366 SAIVSRNADPDQQGVVQGMITGIRGLCNGLGPALYGFVFYLFH 408
Cdd:cd06174 315 FALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATF 357
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
86-408 |
1.63e-21 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 96.89 E-value: 1.63e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 86 GLIHGVKGLLSFLSAPLIGALSD----VWG-RKSFLL-------LTVFFTCAPIPLMRISPWWYFAVISMsgVFAVTFSV 153
Cdd:COG2211 49 GLILLVARLWDAITDPLIGALSDrtrtRWGrRRPWILigaiplaLSFVLLFTAPDLSPTGKLIYALVTYL--LLGLAYTL 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 154 IF----AYVADITQE-HERSTAYGLVSATFAASLVTSPAIGAYLSRAYGDT-----LVVILATAIALLdICFILVAVpeS 223
Cdd:COG2211 127 VNipysALGAELTPDyEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDaalgyRLTALIFAVLGL-LAFLLTFF--G 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 224 LPEKMRPASwgapiswEQADPFASLRKVGQDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIGFTSETVAAFIAVVGIL 303
Cdd:COG2211 204 TKERPVPEE-------EKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLA 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 304 SILAqTVVLGILMRSIGNKNTILLGLGFQILQLAWYGF--GSQPWMMWAAGAVAAM-SSITFPAISAIVSRNADPDQQ-- 378
Cdd:COG2211 277 ALLG-APLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFlgPGNLWLLLVLAALAGIgLGAILVLPWAMLADVVDYDEWkt 355
|
330 340 350
....*....|....*....|....*....|....*
gi 1916914340 379 -----GVVQGMITGIRGLCNGLGPALYGFVFYLFH 408
Cdd:COG2211 356 grrreGLYFGIFTFAIKLGQALAGALAGLLLALFG 390
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
46-403 |
6.78e-21 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 94.54 E-value: 6.78e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 46 PSVYHAVVVIFLEFFAWGLLTT---PMLTVLHQTFpQHTFLMNGLIHGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFF 122
Cdd:COG0738 4 KNYRRALIAIYLLFFLWGFATAlwgPLIPALKDAF-GLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 123 TCAPIPLMRISPWWYFAVIS---MSGVFAVTFSVIFAYVADITQEHeRSTAYGLVSATFAASLVTSPAIGAYLSRAYGDT 199
Cdd:COG0738 83 MALGLLLFALAPSYPLLLLAlflLGLGLGLLDVAANPYVAALGPET-AASRLNLLHAFFSLGALLGPLLGGLLILLGLSL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 200 LVVILATAIALLDICFILVAVPESLPEKMRPASwgapiswEQADPFASLRKVGQDSTVLLICITVFLSYLPEAGQYSSFF 279
Cdd:COG0738 162 SWHLPYLILAVLLLLLALLFLRSKLPEIEEEEE-------EAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLP 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 280 LYLRQVIGFtSETVAAFIAVVGILSILAQTVVLGILMRSIGNKNTILLGLGFQILQLAWYGFGSQPWM-MWAAGAVAAMS 358
Cdd:COG0738 235 LYLKDVLGL-SEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLaLIGLALVGLGL 313
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1916914340 359 SITFPAISAIVSRNADPDQQGVVqGMITGIRGLCNGLGPALYGFV 403
Cdd:COG0738 314 SLMFPTIFSLALDGLGKRTAAAV-SAVLIMGIVGGAIGPPLIGFL 357
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
83-407 |
1.32e-19 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 90.80 E-value: 1.32e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 83 LMNGLIHGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLmrispWWY---FAVISMS----GVFAVTFSVIF 155
Cdd:cd17389 64 LFGGLIGSLFSLLQFLSSPITGAASDVYGRKPVLLLTMIGLAISYAL-----WAVsrsFTIFLLSrivgGISKGNVSLST 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 156 AYVADITQEHERSTAYGLVSATFAASLVTSPAIGAYLS---RAYGDT---LVVILATAIALLDICFILVAVPESLPEKMR 229
Cdd:cd17389 139 AIVADVTSPKKRSKGMALIGVAFSLGFIIGPMIGAYFAsftRSLGEVffsMPALFALVLALADLLFIFFFLPETLPSNLR 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 230 PASWGapisweqadpfaslrkvgqdstvllicitVFLSYLPEAG-QYSSFFLyLRQVIGFTSETVAAFIAVVGILSILAQ 308
Cdd:cd17389 219 RLGLV-----------------------------YFLYLFLFSGlEFTLTFL-THQRFQYTSMQQGKMFFFIGIIMALVQ 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 309 tvvlGILMRSI---GNKNTILLGLGFQILQLAWYGFGSQPWMMWAAGAVAAM-SSITFPAISAIVSRNADPDQQGVVQGM 384
Cdd:cd17389 269 ----GGYVRRIkpgKEKKAVLQGLILLIPAFLLIGWASSVTVLYAGLFLYSFaAATVVPCLTTLVSGYGSDDQKGTVMGI 344
|
330 340
....*....|....*....|...
gi 1916914340 385 ITGIRGLCNGLGPALYGFVFYLF 407
Cdd:cd17389 345 FRSLGALARALGPIVACTVYWLA 367
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
86-404 |
4.14e-19 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 88.76 E-value: 4.14e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 86 GLIHGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMRISPWWYFAVIS---MSGVFAVTFSVIFAYVADIT 162
Cdd:cd17324 37 GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLAralAGLAHGGFWAIAAAYAADLV 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 163 QEHERSTAYGLVSATFAASLVTSPAIGAYLSRAYGDTLVVILATAIALLDICFILVAVPESLPEKMRPASwgapisweqa 242
Cdd:cd17324 117 PPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPGSLG---------- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 243 dPFASLRKVGQDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIGFTSETVAAFIAVVGILSILAqTVVLGILMRSIGNK 322
Cdd:cd17324 187 -LLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVG-SPLAGRLADRGGRR 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 323 NTILLGLGFQILQLAWYGFGSQPWMMWAAGAV-AAMSSITFPAISAIVSRNAdPDQQGVVQGMITGIRGLCNGLGPALYG 401
Cdd:cd17324 265 ALLIALLLLAAALLLLTLLGPSPLLLLVGLVLwGLGFFAAHSALQTRVLRLA-PEARGLASSLYLAAYNLGGALGAALGG 343
|
...
gi 1916914340 402 FVF 404
Cdd:cd17324 344 LVL 346
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
84-404 |
8.40e-19 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 88.04 E-value: 8.40e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 84 MNGLIHGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMRI--SPWWYFavIS-MSGVFAVTFSVIFAYVAD 160
Cdd:cd17331 36 VFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFasSVPMLF--LSrLPSVFMHAMQAAQMVVTD 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 161 ITQEHERSTAYGLVSATFAASLVTSPAIGAYLSRAYGDTLVVILATAIALLDICfILVAVPESLPEKMRPASWGAPISWE 240
Cdd:cd17331 114 LTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLLSIV-LVILLIPSNTKSKREKEAKESASPP 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 241 QADPFASLRKVGQDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIGFTSETVAAFIAVVGILSILAQTVVLGILMRSIG 320
Cdd:cd17331 193 SVFNLKEILRLLRLPGVAFLLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEENGYLMSYAGVLGMVVQGLLVGPLTKRFG 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 321 NKNTILLGLGFQILQLAWYGF-GSQPWMMWAAGAVAAMSSITFPAISAIVSRNADPDQQGVVQGMITGIRGLCNGLGPAL 399
Cdd:cd17331 273 ERSLLKLSVALLAIGYLLLAFvTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTI 352
|
....*
gi 1916914340 400 YGFVF 404
Cdd:cd17331 353 GGALL 357
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
53-403 |
8.90e-19 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 87.67 E-value: 8.90e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 53 VVIFLEFFAWGLLTTPMLTVLHQTFPQHTflMNGLIHGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMRI 132
Cdd:cd17390 3 LVGFLDLFGVSMILPLLSTHIRSLGASPT--VIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 133 SPWWYFAVIS--MSGVFAVTFSVIFAYVADITQEHERSTAYGLVSATFAASLVTSPAIGAYLSRAYGDTLVVILATAIAL 210
Cdd:cd17390 81 STSLALLFLSriPLGIFKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAETDGGFYYVALLCSAIF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 211 LdICFILVAVpeslpekMRPASWGapisweqadpFASLRkvgqdstvLLICITVFLSylpeagqYSSFFLYLRQVIGFTS 290
Cdd:cd17390 161 I-LNAGLVWF-------LLSKLWD----------LLLVR--------FLMGFSVLLF-------RSNFSLYLEERFDLSP 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 291 ETVAAFIAVVGILSILAQTVVLGILmrSIGNKNTILLGLGFQILQ---LAWYGFGSQPWMMWAAGA-VAAMSSITFPAIS 366
Cdd:cd17390 208 KTIGYLISYSGVLGALSGFLVGRIL--KLYKNNEYLLLLHSFILLalsLLGLALAPSIWLLVLCLTpLSISSAVLRTCST 285
|
330 340 350
....*....|....*....|....*....|....*..
gi 1916914340 367 AIVSRNADPDQQGVVQGMITGIRGLCNGLGPALYGFV 403
Cdd:cd17390 286 SLLLSRGKSKERGTLLGVGQSVTSLARILAPLLSGLL 322
|
|
| MFS_SLC46 |
cd17386 |
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ... |
54-397 |
1.36e-18 |
|
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340944 [Multi-domain] Cd Length: 360 Bit Score: 87.33 E-value: 1.36e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 54 VIFLEFFAWGLLTTPMLtvlHQTFPQHTFLMNGLIHGVKGLLSflsAPLIGALSDVWGRKSFLLLTVF--------FTCA 125
Cdd:cd17386 7 IVFLYMFASVLSGPVTQ---NFVYAANFYLYMNLMGSIPPLFS---SLFLGSWSDRYGRKPPLLMSLVglllssliLVLI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 126 PIPLMRISPWWYF---AVISMSGVFAVTFSVIFAYVADITQEHERSTAYGLVSATFAASLVTSPAIGAYLSRAYGDTLVV 202
Cdd:cd17386 81 VYFTTVPSVWWFYlsaIPLALFGGFTAFLSASFAYISDISSEKKRTYRMAILEVALGLGGFLGSLLSGHLFKALGYAWSF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 203 ILATAIALLDICFILVAVpeslpekmrpaswgapisweqadpfaslrkvgqdSTVLLICITVFLSYLPEAGQYSSFFLYL 282
Cdd:cd17386 161 SISAALLLIALLYILFFL----------------------------------TLLILLLLAAFLTIFVLSGESDVLYLFV 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 283 RQVIGFTSETVAAFIAvVGILSILAQTVVLGILMRSIGNKN---TILLGLGFQILQLAWYGFGSQPWMMWAAGAVAAMSS 359
Cdd:cd17386 207 LEKFAWNVKDFSYFST-LGSLIYLTGMLGGVLLLRCLLKMSdstLAMLGLASHILSSLLFAFATNTWMMYLAAVVGMFNG 285
|
330 340 350
....*....|....*....|....*....|....*...
gi 1916914340 360 ITFPAISAIVSRNADPDQqgvvQGMITGIRGLCNGLGP 397
Cdd:cd17386 286 IVGPMIRSILSKLVPKSE----QGKIFSLLSVLESLSP 319
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
86-409 |
1.52e-17 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 84.20 E-value: 1.52e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 86 GLIHGVKGLLSFLSAPLIGALSDVWGRKSFLLLT-------VFFTCAPIPLMRISPWWYFAVISMSGVFAVTFSVIF-AY 157
Cdd:cd06173 37 GLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILAdllrallAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARqAL 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 158 VADITQEHERSTAYGLVSATFAASLVTSPAIGAYLsraygdTLVVILATAIALLDICFILVAVPESLPEKMRPASWGAPI 237
Cdd:cd06173 117 LPELVPKEQLVRANALNSLATQLARIIGPALGGLL------VALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGESS 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 238 SWEQADPFASLRKVGQDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIGFTSETVAAFIAVVGILSILAqTVVLGILMR 317
Cdd:cd06173 191 SLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLG-ALLLGRLSK 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 318 SIGNKNTILLGLGFQILQLAWYGFGSQPWMMWAAGAVAAMSSITF-PAISAIVSRNADPDQQGVVQGMITGIRGLCNGLG 396
Cdd:cd06173 270 RRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFnVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLG 349
|
330
....*....|...
gi 1916914340 397 PALYGFVFYLFHV 409
Cdd:cd06173 350 ALLAGLLADALGL 362
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
51-404 |
8.77e-16 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 79.15 E-value: 8.77e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 51 AVVVIFLEFFAWGLLTTPMLTVLHQTFPQHTFLMnglihGVKGLLSFLSAPLIGALSDVWG-RKSFLLLTVFFTCAPIPL 129
Cdd:COG2223 13 AFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLF-----AIPVLVGALLRIPLGFLVDRFGpRRVLLIGLLLLGIGLLLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 130 MRISPWWYFAVIS-MSGVFA-VTFSVIFAYVADITQEHERSTAYGLVSATFAASLVTSPAIGAYLSRAYGDTLVVILATA 207
Cdd:COG2223 88 ALAVSYWLLLLLGlLLGIGGgGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGI 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 208 IALLDICFILVAVPEsLPEKMRPASwgapisweqADPFASLRKVGQDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIG 287
Cdd:COG2223 168 LLLVVAVLAWLFLRD-PPAGAAAAA---------KASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFG 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 288 FTSETVAAFIAVVGILSILAqTVVLGILMRSIGNKNTILLGLGFQILQLAW--YGFGSQPWMMWAAGAVAAMSSITFPAI 365
Cdd:COG2223 238 LSAATAGLLAALFALLGALG-RPLGGWLSDRIGGRRVLLIVFALMALGLLLlaLALGSLWLFLVLFLLLGLALGGGNGAV 316
|
330 340 350
....*....|....*....|....*....|....*....
gi 1916914340 366 SAIVSRNADPDQQGVVQGMITGIRGLCNGLGPALYGFVF 404
Cdd:COG2223 317 FALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALL 355
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
52-404 |
2.85e-15 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 77.25 E-value: 2.85e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 52 VVVIFLEFFAWGLLTtPMLTVLHQTFPQHTFLMnGLIHGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMR 131
Cdd:cd17489 2 LLANFFFFLSFYLLL-PVLPLYAHDLGGSEAVA-GLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 132 I--SPWWYFAVISMSGV-FAVTFSVIFAYVADITQEHERSTAYGLVSATFAASLVTSPAIGAYLSRAYGDTLVVILATAI 208
Cdd:cd17489 80 LatSVALLLVLRLIHGIgWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 209 ALLDI--CFILVAVPESLPEKMRPASWGapisweqadPFASLRKVgqdstVLLICITVFLSYLPEAGQYSSFFLYLRQvI 286
Cdd:cd17489 160 ALLALllVFLVKDPPPVAAEEAEAGTRA---------FRRLVEKK-----VLPPALILFLASIAYGAISTFLPLYAAE-R 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 287 GFTSetVAAFIAVVGILSILAQtVVLGILMRSIGNKNTILLGLGFQILQLAWYGFGSQPWMMWAAGAVAAMS-SITFPAI 365
Cdd:cd17489 225 GISN--AGLFFTVYAIALLLSR-PFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGfGLLFPAL 301
|
330 340 350
....*....|....*....|....*....|....*....
gi 1916914340 366 SAIVSRNADPDQQGVVQGMITGIRGLCNGLGPALYGFVF 404
Cdd:cd17489 302 QALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVA 340
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
51-408 |
3.91e-15 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 76.83 E-value: 3.91e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 51 AVVVIFLEFFAWGLLTTPMLTVLHQTFPQHtflmnGLIHGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFT---CAPI 127
Cdd:COG2271 18 AYFLNYLDRSNLSVAAPPLQADLGLSAAQL-----GLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWglaTLLF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 128 PLMRiSPWWYFAVISMSGVF-AVTFSVIFAYVADITQEHERSTAYGLVSATFAASLVTSPAIGAYLSRAYGDTLVVILAT 206
Cdd:COG2271 93 GFAT-SFWQLLLLRFLLGLGeAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILG 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 207 AIAlldicfILVAVPeslpekmrpaswgapisweqadpfaslrkvgqdsTVLLICITVFLSYLPEAGQYSSFFLYLRQVI 286
Cdd:COG2271 172 LPG------LLLALL----------------------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVR 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 287 GFTSETVAAFIAVVGILSILAqTVVLGILMRSIG--NKNTILLGLGFQILQLAWYGFGSQPWMMWAAGAVAAMSSI-TFP 363
Cdd:COG2271 212 GLSLAQAGLLLSLPFLAGIVG-SLLGGWLSDRLGrrRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGgAFG 290
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1916914340 364 AISAIVSRNADPDQQGVVQGMITGIRGLCNGLGPALYGFVFYLFH 408
Cdd:COG2271 291 LLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG 335
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
51-408 |
5.15e-15 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 76.54 E-value: 5.15e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 51 AVVVIFLEFFAWGLLTTPMLTV--LHQTF--PQHTFlmnGLIHGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAP 126
Cdd:cd17355 5 LAVTFLILILSWGIRYYFGVFIipIIAEFgwSRAVI---SLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 127 IPLMRI--SPWWYFAVISMSGVF--AVTFSVIFAYVADITQEHERSTAYGLVSATFAASLVTSPAIGAYLSRAYG-DTLV 201
Cdd:cd17355 82 LVLLALatSLWQLYLLWGLLGGGgaGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGwRTAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 202 VILATAIALLDICFILVAVPESLPEKMRPASWGAPisweqADPFASLRKVGQDSTVLLICITVFLSYLPEAGQYSSFFLY 281
Cdd:cd17355 162 LVLALLALLVLVPVLLLLRRRPADLALRAYDDASP-----ASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPY 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 282 LRQvIGFTSETVAAFIAVVGILSILAqTVVLGILMRSIGNKNTILLGLGFQILQLAWYGFG-SQPWMMWAAGAVAAMSSI 360
Cdd:cd17355 237 LAD-RGISPAAAAVALALIGLFNIVG-RLLSGWLGDRYSPRRLLAASYALRALGLALLLLLpFPPLALLLFAALFGLGWG 314
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1916914340 361 -TFPAISAIVSRNADPDQQGVVQGMITGIRGLCNGLGPALYGFVFYLFH 408
Cdd:cd17355 315 aTVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTG 363
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
86-403 |
1.12e-13 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 72.62 E-value: 1.12e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 86 GLIHGVKGLLSFLSAPLIGALSDVWG-RKSFLLLTVFFTCA---PIPLMRISPWWYFAVIsmsGVFAVTFSVIFAYVADI 161
Cdd:cd17335 35 GILIGIRPFVRFLSAPLWGALADRFGkRKALLLLSLLAAVLfflSLFFVAQIFWLLLLLV---ILGAFFSAPVVPLVDSI 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 162 TQEHERSTA--YGLV----SATFAAslvTSPAIGAYLSRAYGDT-LVVILATAIALLDICFILVAVPESLPEKMRPASWg 234
Cdd:cd17335 112 TLQYLGEERerYGKQrlwgSIGFGI---AALLVGILIDRSSTYKnYTIAFYVFAVLMLLALLLALKFPFRPKHPEPNEN- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 235 apisweqadpFASLRKVGQDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIGftSETVAAFIAVVGILSILAQTVVLGI 314
Cdd:cd17335 188 ----------TGGLLALLRNPRVLAFLLVAFLMGFGHGLIYSFLFWHLQDLGG--SKTLIGLLWTVGVVSEIPFFFFSSR 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 315 LMRSIGNKNTILLGLGFQILQLAWYGFGSQPWMMwaaGAVAAMSSITF----PAISAIVSRNADPDQQGVVQGMITgirG 390
Cdd:cd17335 256 LIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLV---LPIELLHGLTFalvwAAAVSYASAAAPPGLRATAQGLLQ---G 329
|
330
....*....|...
gi 1916914340 391 LCNGLGPALYGFV 403
Cdd:cd17335 330 LYFGLGGGLGSLI 342
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
53-220 |
2.76e-13 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 71.07 E-value: 2.76e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 53 VVIFLEFFAWGLLTTPMLTVLHQTFpQHTFLMNGLIHGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMRI 132
Cdd:cd17325 206 LAIFVLAFAFGALEPFLPLYAAELG-GLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPL 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 133 SP--WWYFAVISMSGV-FAVTFSVIFAYVADITQEHERSTAYGLVSATFAASLVTSPAIGAYLSRAYGDTLVVILATAIA 209
Cdd:cd17325 285 ATsfWLLLLLLALLGLgLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALL 364
|
170
....*....|.
gi 1916914340 210 LLDICFILVAV 220
Cdd:cd17325 365 LLAAVLFLLLR 375
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
98-409 |
3.66e-13 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 70.68 E-value: 3.66e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 98 LSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMRISPWWYFAVIS--MSGVFAVTFSVIFAYVADITQEHERSTAYGLVS 175
Cdd:cd17504 46 VSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGraLQGIGGAVFPLAFALVREEFPPERVPVAQGILS 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 176 ATFAASLVTSPAIGAYLSRAYGDTLVVILATAIALLDICFILVAVPESLpekMRPASWGAPIsweqadpfaslrkvgqds 255
Cdd:cd17504 126 ATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAALVPLIDLRLL---RRRNVLLANI------------------ 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 256 TVLLICITVFLSYlpeagQYSSFFLYLRQVIGFT-SETVAAFIAVVGILSILAQTVVLGILMRSIGNKNTILLGLGFQIL 334
Cdd:cd17504 185 TALLAGFGMFMVF-----QLLPQLLQLPTPTGFGlGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAV 259
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1916914340 335 QLAWYGF-GSQPWMMWAAGAVAAM-SSITFPAISAIVSRNADPDQQGVVQGMITGIRGLCNGLGPALYGFVFYLFHV 409
Cdd:cd17504 260 GLLLLALlHSSLWALVVALLLIGIgLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAILTTYTV 336
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
93-408 |
1.96e-12 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 69.03 E-value: 1.96e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 93 GLLSFLSAPLIGALSDVWGRK-----SFLLLTVFFTCApIPLMRISPWWYFAVISMSGVFAVTFSVIF--AYVADITQEH 165
Cdd:COG2270 62 GLLVALLAPVLGAIADRSGRKkpflaFFTLLGVLATAA-LFFVAPGGLWLGLLLFVLANIGFEGSLVFynAFLPDIATPE 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 166 ER----STAY------GLVSATFAASLVTSPAIGAYLSRAYGDTLVVILATAIALLDICFILVAVPESLPEKMRPASWGA 235
Cdd:COG2270 141 EIgrvsGLGWalgylgGVLLLLINLALFLKPEAFGLPDAGEAVRISFLLTALWWLLFALPLFLFLPERPRPGPAPPRGAV 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 236 PISWEQAdpFASLRKVGQDSTVL--LICITVFLSYLpeAGQYSSFFLYLRQVIGFTSETVAAFIAVVGILSILAqTVVLG 313
Cdd:COG2270 221 RAGFREL--RRTLRELRRYRDLLrfLLAYFFYRDGV--QTVIAFAGIYAAGVLGFSTTELIVFGLLVQIVAALG-ALLFG 295
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 314 ILMRSIGNKNTILLGLGFQILQLAWYGFGSQPWMMWAAGAVAAMSSITFPAIS-AIVSRNADPDQQGV------VQGMIT 386
Cdd:COG2270 296 RLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWILGLLIGLVMGGIQALSrSLLARLIPPGREAEffglyaLSGKAA 375
|
330 340
....*....|....*....|..
gi 1916914340 387 GIrglcngLGPALYGFVFYLFH 408
Cdd:COG2270 376 SF------LGPLLFGLVTQLTG 391
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
86-410 |
2.17e-11 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 65.26 E-value: 2.17e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 86 GLIHGVKGLLSFLSAPLIGALSDVWG-RKSFLLLTVFFTCAPIPLMRISPWWYFAVISMS------GVFAvtfSVIFAYV 158
Cdd:cd17370 37 GLIEGLAEALGSLLRLFSGYLSDRTGkRKPLVILGYGLSALAKPLLALAGSWQLVLLLRIlerlgkGIRT---PPRDALL 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 159 ADITQEHERSTAYGLVSA--TFAASLVTSPAIGAYLSRAYGDTLVVILATAIALLDICFILVAVPESlPEKMRPASWGAP 236
Cdd:cd17370 114 ADATPPSGRGKAFGLHRAldTLGAVLGPLLAALLLYLLGGNYRTIFLLAAIPALLALLILLFVVKEY-PRPPKLRKKSKK 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 237 ISWEQADPFAslrkvgqdstvLLICITVFLSylpEAGQYS-SFFLYLRQVIGFTSETVAAFIAVVGILSILAqTVVLGIL 315
Cdd:cd17370 193 TSLKKLPKAF-----------WLYLLAVALF---ALGNFSfAFLILRAQELGLSAALIPLLYALFNLVYALA-AYPAGRL 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 316 MRSIGNKNTILLGLGFQILQLAWYGFGSQPWMMWAAGAVAAMS-SITFPAISAIVSRNADPDQQGVVQGMITGIRGLCNG 394
Cdd:cd17370 258 SDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYmGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWL 337
|
330
....*....|....*.
gi 1916914340 395 LGPALYGFVFYLFHVE 410
Cdd:cd17370 338 LASLIAGYLWDLISPS 353
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
63-386 |
2.32e-11 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 65.29 E-value: 2.32e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 63 GLLTTPMLTVLHQTFPQHTFLMNGLIHGVKGLLSFLSAPLIGALSDVWGRKSFLL--LTVFFTCAPIPLMRISPWWYFAV 140
Cdd:cd17473 15 GAAIAPALPAIAQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIagLLLYGIGGVAGLFLDSLYALLAS 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 141 ISMSGVF-AVTFSVIFAYVADITQEHERSTAYGLVSATFAASLVTSPAIGAYLS----RAygdtlvVILATAIALldICF 215
Cdd:cd17473 95 RALLGIGvAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAeigwRA------PFLVYLLAL--PVL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 216 ILVAVpeSLPEKMRPASWGAPISWEQADPFASLRkvgqdstVLLICITVFLSYLPEAGQYSSFFLYLRQVIGFTSETVAA 295
Cdd:cd17473 167 ILVLL--FLPEPARKSKSAASPGAATAAALPWKR-------VLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 296 FIAVVGILSILAqTVVLGILMRSIGNKNTILLGLGFQILQLAWYGFGSQPWMMWAAGAVAAM-SSITFPAISAIVSRNAD 374
Cdd:cd17473 238 ALAIASLAGAIG-ALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLgFGLLLPTLNSWAMSLVP 316
|
330
....*....|..
gi 1916914340 375 PDQQGVVQGMIT 386
Cdd:cd17473 317 PELRGRAMGIVT 328
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
98-407 |
7.99e-11 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 63.74 E-value: 7.99e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 98 LSAPLIGALSDVWGRKSFLL--LTVFFTCAPIPLMRISPWWYFAVISMSGV-FAVTFSVIFAYVADITQEHERSTAYGLV 174
Cdd:cd17474 49 VLMPVAGVLADRFGRKKVLLpgLLLFGIGGLLCGLSDSFALLLAGRALQGIgAAGLGPLALTLIGDLFEGGERAKAMGLY 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 175 SATFAASLVTSPAIGAYLSRA--YGDTLVVILATAIALLDICFILvavpESLPEKMRPASWGAPISWEQADPFASLRKVG 252
Cdd:cd17474 129 EAALGLGIAVGPLLGGLLAAIswRYPFFLLAALIPVAFLAILFLL----PEPKEKAKSSSATKLRDLKKALRGRGLLTFL 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 253 QDSTVLLICITVFLSYLPeagqyssffLYLRQVIGFTSETVAAFIAVVGILSILAQTVVLGILMRSIGNKNTILLGLGFQ 332
Cdd:cd17474 205 VSAFLYFFLYFAFLTYLP---------FLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLY 275
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1916914340 333 ILQLAWYGFGSQPWMMWAAGAVAAMSS-ITFPAISAIVSRNADPDQQGVVQGMITGIRGLCNGLGPALYGFVFYLF 407
Cdd:cd17474 276 ALSLLLLGFVPSLALLLIAIVLFGLGLgLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIF 351
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
101-407 |
1.75e-10 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 62.58 E-value: 1.75e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 101 PLIGALSDVWGRKSFLLL-TVFFTCAPIpLMRISP--WWYFAVISMSGVF-AVTFSVIFAYVADITQEHERSTAYGLVSA 176
Cdd:cd17321 49 LLAGRLGDRFGRKRVFLIgLALFGLASL-LCALAPslAFLIAARALQGIGaAAIMPASLALIAATFPGERRGRALGLWGA 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 177 TFAASLVTSPAIGAYLSRAYGDTLVVILATAIALldICFILVavpeslpekmrpaswgapisweqadpfaslrkvgqdST 256
Cdd:cd17321 128 VVGIGAALGPLLGGLLLELFGWRWIFLINVPIGL--VALLLA------------------------------------RT 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 257 VLLICITVFLSYLPEAGQYSSFFLYLRQVIGFtSETVAAFIAVVGILSILAQTVVLGILMRSIGNKNTILLGLGFQILQL 336
Cdd:cd17321 170 FSGAVLAAFLLGAALGGLLFLLPLYLQGVLGY-SPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGL 248
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1916914340 337 AWYGFGSQPWMMWAAGAVAAMSSI----TFPAISAIVSRNADPDQQGVVQGMITGIRGLCNGLGPALYGFVFYLF 407
Cdd:cd17321 249 LLLALLGADSSVWLLLPGLVLLGLglglFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLTAG 323
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
102-404 |
4.36e-10 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 61.44 E-value: 4.36e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 102 LIGALSDVWGRKSFLLL-TVFFTCAPIPLMRISPWWYFAVISM-SGVFAVTFSVI-FAYVADITQEHERSTAYGLVSATF 178
Cdd:cd17320 53 LYGPLSDRFGRRPVLLAgLLLFILASLLCALASSIEQLLIARFlQGLGAAAGSVVaRAIVRDLYSGAELAKIFSLLMMIL 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 179 AASLVTSPAIGAYLSRAYGDTLVVILATAIALLdiCFILVA--VPESLPEKMRPASWGApisweqadPFASLRKVGQDST 256
Cdd:cd17320 133 AIAPALAPLLGGLLLLFFGWRAIFVFLALLGLL--LLLLVLlfLPETLPEEKRKPLLSS--------LLRAYKRVLKNRR 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 257 VLL------ICITVFLSYLPEAGqyssfFLYLrQVIGFTSETVAAFIAVVGILSILAqTVVLGILMRSIGNKNTILLGLG 330
Cdd:cd17320 203 FLGyalalgLSFAGLFAYLAAAP-----FIYI-EQLGLSPAQFGLLFALNAIALILG-SLLNGRLVRRFGPRRLLRLGLL 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 331 FQI------LQLAWYGFGSQPWMMWAAGAVAAMSSITFPAISAIVSRnADPDQQGVVQGMITGIRGLCNGLGPALYGFVF 404
Cdd:cd17320 276 LLLaaalvlLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALE-PFPHVAGTASALLGFLQFLIGALAGALVGLLP 354
|
|
| MFS_1_like |
pfam12832 |
MFS_1 like family; This family contains proteins related to the MFS superfamily. |
86-407 |
5.88e-10 |
|
MFS_1 like family; This family contains proteins related to the MFS superfamily.
Pssm-ID: 432817 [Multi-domain] Cd Length: 362 Bit Score: 60.72 E-value: 5.88e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 86 GLIHGVKGLLSFLSAPLIGALSDVWG-RKSFLLLTVFF-TCAPIPLMRISP----WWYFAVISMSGVFAVTFSVIFAyVA 159
Cdd:pfam12832 37 GLITAILPLTRILAPPIWGWLADRTGkRKAVVRLASILaAVLFLSVLFIPIsltfWWLALLVVLFSFFWNAILPQFE-VA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 160 DITQEHERSTAYGLV----SATFAaslVTSPAIGAYLSRAYGDTL-VVILATAIALLDICFILVAVPeslpekmrPASWG 234
Cdd:pfam12832 116 TLQHLGEKRKDYGRQrlwgSVGFA---LSVFGLGALFDHYSVGLLpSVLFYLFAALMLLSLLLPLAP--------PEMEY 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 235 APISWEQADPFASLRkvgqDSTVLLICITVFLSYLPEAGQYSSFFLYLRQViGFTSETVAAFIAvVGILSILAQTVVLGI 314
Cdd:pfam12832 185 ESKGGSKAVFWNLLK----QPEVIIFFLAAFLLGFSHGPFYTFLFLYLENL-GASNTLLGALWA-LGVVAEIPLFFYAHR 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 315 LMRSIGNKNTILLGLGFQILQLAWYGFG-SQPWMMWAAGAVAAMS-SITFPAISAIVSRNADPDQQGVVQGMITGIR-GL 391
Cdd:pfam12832 259 LLRRFGHRNLLIIALLLTALRWLLYAFFvENPWLVLPIQFLHAISfGLTHAAAIEYVRRIFPGSLQGTGQALYSGLYfGL 338
|
330
....*....|....*.
gi 1916914340 392 CNGLGPALYGFVFYLF 407
Cdd:pfam12832 339 GGALGSLIGGQLWDLF 354
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
67-403 |
4.35e-09 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 58.34 E-value: 4.35e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 67 TPMLTVLHQTFpQHTFLMNGLIHGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMRISP--WWYFAVISMS 144
Cdd:cd17478 16 PALLPLLIAKL-GLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPnyWLLLLLVALA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 145 GVFAVTFSVIFAYVADITQEHERSTAYGLVSA--TFAASLvtSPAIGAYLSRAYGD---TLVVILATAIALLDICFILVA 219
Cdd:cd17478 95 GIGSAAFHPEGARLASQAAGGRRGLAMSIFSVggNLGFAL--GPLIAAALVALFGGlglLILLIIPGLAVALLLLRLRPL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 220 VPESLPEKMRPASWGAPisweqadpfaslrKVGQDSTVLLICITVFLSYLPEAGqYSSFFLYLRQVIGFTSETVAAFIAV 299
Cdd:cd17478 173 KKPEAKKAAAKSSARST-------------LKGVWRALLLLLIIVFLRSWVLSS-LTTFLPFYLVQRGYSLVFAGLLLSL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 300 VGILSILAqTVVLGILMRSIGNKNTILLGLGFQILQLAWYGFGSQPWMMWAAGAVAAMSSITFPAISAIVSRNAdPDQQG 379
Cdd:cd17478 239 FLFAGAIG-TLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLAQELL-PGNVG 316
|
330 340
....*....|....*....|....
gi 1916914340 380 VVQGMITGIRGLCNGLGPALYGFV 403
Cdd:cd17478 317 LASGLMMGLSFGLGGIGAPVLGAL 340
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
47-222 |
6.70e-09 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 57.57 E-value: 6.70e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 47 SVYHAVVVIFLEFFAWGLLTTPMLTVLHQTFpQHTFLMNGLIHGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAP 126
Cdd:COG2271 181 RFWLLALAYFLVYFALYGFLTWLPTYLVEVR-GLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAA 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 127 IPLMRI----SPWWYFAVISMSGVFA-VTFSVIFAYVADITQEHERSTAYGLVSATFAASLVTSPAIGAYLSRAYGDTLV 201
Cdd:COG2271 260 LALLLLallpSPALAIALLFLAGFGLgGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAA 339
|
170 180
....*....|....*....|.
gi 1916914340 202 VILATAIALLDICFILVAVPE 222
Cdd:COG2271 340 FLLLAALALLAALLALLLLRE 360
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
65-383 |
7.17e-09 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 57.61 E-value: 7.17e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 65 LTTPMLTVLHQTFPQHTFLMNGLIHGVKGLL-SFLSAPLiGALSDVWGRKSFLL--LTVFFTCAPIPLMRISPWWYFAVI 141
Cdd:cd17472 14 LVLPVLSVYAKSLPGATPTLIGLALGIYGLTqAIFQIPF-GLLSDRIGRKPVILfgLLLFIAGSLLAAYATSIYGLILGR 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 142 SMSGVFAVTfSVIFAYVADITQEHERSTAYGLVSATFAASLVTSPAIGAYLSRAYGDTLVVILATAIALLDICFILVAVP 221
Cdd:cd17472 93 ALQGSGAIS-SVVMALLADLTREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVP 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 222 ESLPEKMRPASWGapisweqadpfASLRKVGQDSTVLLICITVFLSYLpeagQYSSFF----LYLRQVIG--------FT 289
Cdd:cd17472 172 DPPKIVQISEKEK-----------KKLKKLLKNKRLLRLDFSIFILHF----VLMAFFyilpLLLTQLGGgkgqlwkvYL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 290 SETVAAFIAVVgILSILA-------QTVVLGILMRSIGnkntiLLGLGFQILQLAWYGFGSQPWMmwaagavAAMSSITf 362
Cdd:cd17472 237 PAILIGFILMV-PFVIYAekkgkmkQVFVSSILLIAVG-----FLLLLFAATSLWLLIIGLIIFF-------IGFNLLE- 302
|
330 340
....*....|....*....|.
gi 1916914340 363 PAISAIVSRNADPDQQGVVQG 383
Cdd:cd17472 303 ALLPSLVSKIAPKEYRGTAMG 323
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
102-348 |
2.43e-08 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 56.02 E-value: 2.43e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 102 LIGALSDVWG-RKSFLLLTVFF---TCAPIPLMRiSPWWYFAV-ISMSGVFAVTFSVIFAYVAD-ITQEHERSTAY--GL 173
Cdd:cd17471 51 WLGRLSDRGGdRKPLILLALLAgalGYLLFAFLR-NYWVLLLVgVVLLSLGAAAFPQLFALAREyADRSSGRDATLfnSV 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 174 VSATFAASLVTSPAIGAYLSRAYGDTLVVILATAIALLdicfILVAVPESLPEKMRPAswgapiswEQADPFASLRKVGQ 253
Cdd:cd17471 130 LRAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLV----VALLVLFLLPSVKPPA--------QKATPASSLVKAPV 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 254 DSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIGFTSETVAAFIAVVGILSILAqTVVLGILMRSIGNKNTILLGLGFQI 333
Cdd:cd17471 198 NRRLLLLFAAFTLLFAANSMYIIAMPLYVTNELGGSESWVGLLFGLAAALEIPI-MLLAGLLAKRFGKRRLLLAGFLAGV 276
|
250
....*....|....*
gi 1916914340 334 LQLAWYGFGSQPWMM 348
Cdd:cd17471 277 LFYLGLALATSLWQL 291
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
86-403 |
5.36e-08 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 54.96 E-value: 5.36e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 86 GLIHGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMRISP--WWYFAVISMSGVFAVTFSVIFAYVADITQ 163
Cdd:cd17391 39 GLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTnvWQLLILRLLQGVFSGYVPNATALIASQTP 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 164 EHERSTAYGLVSATFAASLVTSPAIGAYLSRAYGDTLVVILATaiALLDICFILVAVpeSLPEKMRPASWGAPISWEQAd 243
Cdd:cd17391 119 KEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITG--GLLFLAFLLTLF--FVKEDFKPVEKKKMVSTKEV- 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 244 pfasLRKVGQDSTVLLICITVFLSylpeagQYSSFF------LYLRQVIGFTSETvaAFIA-----VVGILSILAqTVVL 312
Cdd:cd17391 194 ----WNSVPNPSLLISLFVTTFII------QLANQSiepiltLYIRQLMGDASNL--AFISglvfsATGVSSLLS-APRL 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 313 GILMRSIGNKNTILLGLGFQILQLAWYGFGSQPW-MMWAAGAVAAMSSITFPAISAIVSRNADPDQQGVVQGMITGIRGL 391
Cdd:cd17391 261 GKLGDRIGHHRILLGALLASALLYIPQAFVQTPWqLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYL 340
|
330
....*....|..
gi 1916914340 392 CNGLGPALYGFV 403
Cdd:cd17391 341 GNVAGPLLGSAI 352
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
51-320 |
6.18e-08 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 54.05 E-value: 6.18e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 51 AVVVIFLEFFAWGLLTTPMLTVLHQTFPQHTFLMNGLihgvkGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLM 130
Cdd:COG0477 22 GTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAY-----LLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLC 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 131 RISP--WWYFAVISMSGVF-AVTFSVIFAYVADITQEHERSTAYGLVSATFAASLVTSPAIGAYLSRAYGDTLVVILATA 207
Cdd:COG0477 97 GLAPspELLIAARALQGIGaGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAP 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 208 IALLDIcFILVAVPESLPEKMRPASWGAPISWEQADPFASLRKVGQDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIG 287
Cdd:COG0477 177 LGLLAL-VLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLA 255
|
250 260 270
....*....|....*....|....*....|...
gi 1916914340 288 FTSETVAAFIAVVGILSILAQTVVLGILMRSIG 320
Cdd:COG0477 256 LLLLAALLLLLLLLLLLALLLALLLLLLLLLLL 288
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
94-211 |
7.57e-08 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 54.47 E-value: 7.57e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 94 LLSFLSAPLIGALSDVWGRKSFLLLT-VFFTCAPIPLMRISPWWYFAVISM-SGVF-AVTFSVIFAYVADITQEHERSTA 170
Cdd:cd17370 245 LVYALAAYPAGRLSDRIGRKKLLILGyLSLALAYLGFALGSSLWLLLLGFIlWGLYmGAQESIERAAVADLVPAELRGTA 324
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 1916914340 171 YGLVSATFAASLVTSPAIGAYLSRAYGDTLVVILATAIALL 211
Cdd:cd17370 325 YGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALI 365
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
53-232 |
2.92e-07 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 52.58 E-value: 2.92e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 53 VVIFLEFFAWGLLTTPMLTVLHQTFPQHTFLMNGLIhgvkGLLSFLSAPLIGALSDVWGRK-----SFLLLTVFftCAPI 127
Cdd:COG2223 215 FGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALF----ALLGALGRPLGGWLSDRIGGRrvlliVFALMALG--LLLL 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 128 PLMRISPWWYFAVISMSGVFA-VTFSVIFAYVADITQEHERSTAYGLVSATFAASLVTSPAIGAYLSRAYGdTLVVILAT 206
Cdd:COG2223 289 ALALGSLWLFLVLFLLLGLALgGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATG-SYTAAFLV 367
|
170 180
....*....|....*....|....*.
gi 1916914340 207 AIALLDICFILVAVpesLPEKMRPAS 232
Cdd:COG2223 368 FAVLALVALVLTLL---LYRRPRRAA 390
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
256-408 |
3.85e-07 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 51.90 E-value: 3.85e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 256 TVLLICITVFLSYLpEAGQYSSFFLYLRQVIGFTSETVAAFIAVVGILSILAQtVVLGILMRSIGNKNTILLGLGFQILQ 335
Cdd:COG2814 11 ALLALALGAFLSGL-GIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGA-PLAGRLADRFGRRRVLLLGLLLFALG 88
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1916914340 336 LAWYGFGSQPWMMWAAGAVAAM-SSITFPAISAIVSRNADPDQQGVVQGMITGIRGLCNGLGPALYGFVFYLFH 408
Cdd:COG2814 89 SLLCALAPSLWLLLAARFLQGLgAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG 162
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
260-407 |
4.79e-07 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 51.65 E-value: 4.79e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 260 ICITVFLSYLPEAGQYSSFFLYLRQVIGFTSETVAAFIAVVGILSILAQtVVLGILMRSIGNKNTILLGLGFQILQLAWY 339
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQ-PLAGRLSDRFGRRRVLLIGLLLFALGLLLL 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1916914340 340 GFGSQPWMMWAAGAVAAM-SSITFPAISAIVSRNADPDQQGVVQGMITGIRGLCNGLGPALYGFVFYLF 407
Cdd:pfam07690 80 LFASSLWLLLVLRVLQGLgAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF 148
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
54-217 |
5.66e-07 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 51.84 E-value: 5.66e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 54 VIFLEFF---AWGLLTTPMLTVLHQTFPQHTFLMNGLIHGVKGLLSFLSAPLIGALSDVWGRK---SFLLLTVFFTCAPI 127
Cdd:cd17353 217 LLWLMFFlnaTAGLMLIGQAKPIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKntlSIAFLIQGVAMFLL 296
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 128 PLMRISPWWYFAVISMSGV-FAVTFSVIFAYVADITQEHERSTAYGLVSATFAASLVTSPAIGAYLSRAYGDTLVVILAT 206
Cdd:cd17353 297 PFIGSVAVLFVLGVALIGFcYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAA 376
|
170
....*....|.
gi 1916914340 207 AIALLDICFIL 217
Cdd:cd17353 377 ALSLVALALAL 387
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
98-404 |
8.37e-07 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 51.45 E-value: 8.37e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 98 LSAPLIGALSD-------------VWGRKSFLLLTVFFTCAPIPLMRISPWWYFAVISMSGVFAVTFSVIF-AYVADITQ 163
Cdd:cd17332 50 INDPLMGYLIDrtrsrwgrfrpwlLWGAIPLALLFVLLFTTPDGSGTGKLIYALITYILLDLLYTLVNIPYtALIPELTD 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 164 E-HERS--TAYGLVSATFAASLVTS--PAIGAYLSRAYGDTLVVILATAIALLDICFILVAVPESlpekmRPASWGAPIS 238
Cdd:cd17332 130 DpEERTslTSWRMFFATIGGLLVTVlpPPLVAYFGGGNASRGYFLTALIIGIIGIILLLICFFGT-----RERVVPPEEE 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 239 WEQADPFASLRKVGQDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIGFTSETVAAFIAVVGILSILaqTVVLGILMRS 318
Cdd:cd17332 205 KSKLPLLKSLKALLKNRPFLILLLAYLLYFLAFNIVNTVLVYYFKYVLGGRAELVLLLLLILSGALLA--LLPWPPLKKR 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 319 IGNKNTILLGLGFQILQLAWYGFGSQP--WMMWAAGAVAAM-SSITFPAISAIVSRNADPDQ--QGV-VQGMITGIRGLC 392
Cdd:cd17332 283 FGKKKAFFIGLLLAILGLLLLFFLPPGnlVLILVLAVLAGIgYGGANLLPWAMLADVIDYGElkTGKrREGIFYSVMTFF 362
|
330
....*....|..
gi 1916914340 393 NGLGPALYGFVF 404
Cdd:cd17332 363 RKLGLALAGALV 374
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
83-403 |
8.63e-07 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 51.02 E-value: 8.63e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 83 LMNGLIHGVKGLLSFLSAPLIGALSDVWG-RKSFLLLTVFFTCAPIPLM-RISPWWYFAVISMSGV-FAVTFSVIFAYVA 159
Cdd:cd17477 31 ALIGLVASAYYLGILLGSPLVPRLIRRVGhIRAFAAGAAITAVSVLLLAlTDSPWVWFLLRFVMGIgLAGLFVVSESWLN 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 160 DITQEHERSTAYGLVSATFAASLVTSPAIGAYLSRAyGDT--LVVILATAIALLDICFILVAVPESlpekmrpaswgapi 237
Cdd:cd17477 111 ALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTA-GALpfLIAAVLLLLALVPLLLTRRAAPEI-------------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 238 swEQADPFASLRKVgqdSTVLLICITVFLSYLPEAGQYSSFFLYLRQViGFTSETVAAFIAVVGILSILAQtVVLGILMR 317
Cdd:cd17477 176 --EEAESISLRRLL---RIAPLALLGAFVAGFLEGAFYSLLPLYGLRL-GLSVAQAALLLAAFVLGGLLLQ-WPLGWLAD 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 318 SIGNKNTILL-GLGFQILQLAWYGFGSQPWMMWAAGAVAAMSSIT-FPAISAIVSRNADPDQQGVVQGMITGIRGLCNGL 395
Cdd:cd17477 249 RFDRRRVLLGcALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPlYTLALALAGDRLPGDELVAANAALLLLYGLGSVI 328
|
....*...
gi 1916914340 396 GPALYGFV 403
Cdd:cd17477 329 GPLLAGAL 336
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
43-178 |
1.29e-06 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 50.36 E-value: 1.29e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 43 IGEPSVYHAVVVIFLEFFAWGLLTTPMLTVLHQTFpQHTFLMNGLIHGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFF 122
Cdd:COG2814 204 LRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVL-GLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLL 282
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1916914340 123 TCAPIPLMRISPWWYFAVISM---SGVFAVTFSVIFAYVADITQEHERSTAYGLVSATF 178
Cdd:COG2814 283 LALGLLLLALAGSLWLLLLALfllGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAF 341
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
84-407 |
1.94e-06 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 49.91 E-value: 1.94e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 84 MNGLIHGVKGLLSFLSAPLIGALSDVWG-RKSFLLLTVFFTCAPIPLMRI--SPWWYFAVISMSGVFAVTFSVIFAYVAD 160
Cdd:cd17490 32 MIGIILGAYGISQMLLRIPLGILSDRIGkRKLFIIIGLLFTVLASLIMILfpSPWGLLIARFLSGIAAATWVSFTVLYAS 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 161 ITQEHERSTAYGLVSATFAASLVTSPAIGAYLSRAYGDTLVVILATAIALLDICFILVAVPESLPEKMRPASWgapiswe 240
Cdd:cd17490 112 YFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKEERREKKPVLTEL------- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 241 qadpfASLRKVGQDSTVLLICITVFLS-YLPEAGQYSSFFLYLRQvIGFTSETVAAFIAVVGILSILAQTVVLGILMRSI 319
Cdd:cd17490 185 -----KELLSVLKDKKLLFFSLLAILQqMITFSTTFGFTPLIAKQ-LGASSFQLGLLSIIYLLPNALASLLSGTLFYKKL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 320 GNKNTILLGLGFQILQLAWYGFGSQPWMMWAAGAVAAMSS-ITFPAISAIVSRNADPDQQGVVQGMITGIRGLCNGLGPA 398
Cdd:cd17490 259 GERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTgILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPV 338
|
....*....
gi 1916914340 399 LYGFVFYLF 407
Cdd:cd17490 339 LVGIISEAF 347
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
101-421 |
3.60e-06 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 49.23 E-value: 3.60e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 101 PLIGALSD----VWGR-KSFLLLTVFFTCAPIPLMRISPWWYFA------VISMSGVF-AVTFSVI--FAYVADITQE-H 165
Cdd:pfam13347 51 PIVGHIIDrtrtRWGRrRPWLLLSAIILAVSFILLFTPPELGRAplfiwlLATYILLRiAYTFFEIpyWSLGPELTRDyD 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 166 ER----------STAYGLVSATFAASLVTSPAIGAYLSRAYGDTLVVILATAIALLDICFILVAVPESLPEKMRPASWGA 235
Cdd:pfam13347 131 ERtsltsyrsffSVGGGLLAAALAFPLVLILGGTGLERKGYRIFALIGAVLMLLGVIITAAGTKERVSMRSKEDTGQKEA 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 236 PISWEQadpfasLRKVGQDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIGFTSEtVAAFIAVVGILSILAQTVVLGIL 315
Cdd:pfam13347 211 GSLLDM------LKEVFRNRAFLILLASFLLAALAMGVLNGLLLYYFRYVLGNGFA-ASAFPLVFTIGALLGIPLWPPLA 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 316 MRsIGNKNTILLGLGFQI--LQLAWYGFGSQPWMMWAAGAVA----AMSSITFPAISAIVSrNADPDQQGV-VQGMITGI 388
Cdd:pfam13347 284 KR-IGKKNTYILGALITIagFALALLLGPNNTLLFLVLYIIIgfgyGSSFFLPWSMLADVV-DYGELRTGKrREGTFFAM 361
|
330 340 350
....*....|....*....|....*....|....*..
gi 1916914340 389 RGLCN----GLGPALYGFVFYLFHveLNEMDAVESPD 421
Cdd:pfam13347 362 WSFISklatGVGLGVSGLLLSAFG--YNAGDSVQSPQ 396
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
51-211 |
4.29e-06 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 48.75 E-value: 4.29e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 51 AVVVIFLEFFAWGLLTTPMLTVLHQTF---PQHTFLMNGLIhgvkGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPI 127
Cdd:cd17316 182 LILLWFFISFGYYGLTTFLPTYLQTVLglsPATSSLYLLLI----SLGALVGALIAGLLSDRIGRKKTLVIGLILSGILA 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 128 PLM----RISPWWYFAVISMSGVFAVTFSVIF-AYVADITQEHERSTAYGLVSAT-FAASLVTSPAIGAYLSRAYGDTLV 201
Cdd:cd17316 258 LPLfyllSGSPTLLLLLLFILSFFVGGVWGALyAYLAELFPTEVRATGVGLSYNLgRLGGGGAPPLIALLLASTGGTGVP 337
|
170
....*....|
gi 1916914340 202 VILATAIALL 211
Cdd:cd17316 338 ALILALLAIV 347
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
83-402 |
4.32e-06 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 49.15 E-value: 4.32e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 83 LMNGLIHGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMRISP--WWYFAVISMSGVFAVTFSVIFAYVAD 160
Cdd:PRK09874 54 MWSGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGLAQniWQFLILRALLGLLGGFVPNANALIAT 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 161 ITQEHERSTAYGLVSATFAASLVTSPAIGAYLSRAYGDTLVVILATAIalLDICFILVAVpeSLPEKMRPASWGAPISWE 240
Cdd:PRK09874 134 QVPRNKSGWALGTLSTGGVSGALLGPLAGGLLADSYGLRPVFFITASV--LFLCFLVTLF--CIRENFQPVSKKEMLHMR 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 241 QAdpFASLRkvgQDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIGFTSET--VAAFIAVVGILSILAQTVVLGILMRS 318
Cdd:PRK09874 210 EV--VTSLK---NPKLVLSLFVTTLIIQVATGSIAPILTLYVRELAGNVSNIafISGMIASVPGVAALLSAPRLGKLGDR 284
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 319 IGNKNTILLGLGFQILQLAWYGFGSQPWMMWAAG-AVAAMSSITFPAISAIVSRNADPDQQGVVQGMITGIRGLCNGLGP 397
Cdd:PRK09874 285 IGPEKILITALIFSVLLLIPMSFVQTPLQLGILRfLLGAADGALLPAVQTLLVYNSSNQIAGRIFSYNQSFRDIGNVTGP 364
|
330
....*....|..
gi 1916914340 398 -------ALYGF 402
Cdd:PRK09874 365 lmgaaisANYGF 376
|
|
| MFS_BCD_PucC-like |
cd06176 |
Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator ... |
94-361 |
5.13e-06 |
|
Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator Superfamily; The bacteriochlorophyll delivery (BCD) family, also called PucC family, is composed of the PucC protein and related proteins including LhaA (also called ORF477 and F1696) and bacteriochlorophyll synthase 44.5 kDa chain (also called ORF428). These proteins are found in photosynthetic organisms. Rhodobacter capsulatus LhaA and PucC are implicated in light-harvesting complex 1 and 2 (LH1 and LH2) assembly. PucC may function to shepherd or sequester LH2 alpha and beta proteins to facilitate proper assembly, as well as deliver bacteriochlorophyll a to nascent LH2 complexes. The BCD family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 349950 [Multi-domain] Cd Length: 409 Bit Score: 48.65 E-value: 5.13e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 94 LLSFLSaPLIGALSDVWGRKSF----------LLLTVFFTCAPIPLMRIS-----PWWYFAVIS--MSGV-FAVTFSVIF 155
Cdd:cd06176 47 LVAPLR-VWIGHRSDTHPLRGYrrtpyiwlgmLLLALGLALAPFAALLLAgaafwLGLALAVLAflLYGIgVGAAGTAFL 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 156 AYVADITQEHERSTAYGLV-SATFAASLVTSPAIGAYLSRAYGDTL--VVILATAIALLDICFILVAVpeslpEKMRPAS 232
Cdd:cd06176 126 ALLADLTPEERRPRAVTVVwTMLILGIIVTAIVFGRLLDPYSPERLiqVFQIVALVALLLALLALWGV-----ERRRSRA 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 233 WGAPISWEQADPFASLRKVGQDSTVLLICITVFLSYLpeagqysSFFL-------YLRQVIGFTSETVAAFIAVVGILSI 305
Cdd:cd06176 201 ALAAEEAPPETFREALRLLWASPQARRFFIFLFLSTL-------ALFMqdvilepFGGEVFGMSVGETTRLTAIWGGGTL 273
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1916914340 306 LAQTVVLGILMRSIGNKNTILLGLGFQILQ---LAWYGFGSQPWM-------------MWAAGAVAAMSSIT 361
Cdd:cd06176 274 LGMLLAGFLLSRRLGKKRTAALGCLLSALGfllLALAGLLGNPWLfrpgvfllglgngLFTVGALTLMMDLT 345
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
101-407 |
5.85e-06 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 48.34 E-value: 5.85e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 101 PLIGALSDVWGRKS-FLLLTVFFTCAPIpLMRISPWWYFAVIS--MSGVF-AVTFSVIFAYVADITQEHERSTAYGLVSA 176
Cdd:cd17503 49 PLSGWLADRFGTRRlFLTALALFTLGSL-LCGLAPNLASLIIFriLQGFGgGVLIPLAQTILLRIYPPEKRGAAMGLVGL 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 177 TFAASLVTSPAIGAYLSRAYGDTLVVILATAIALldICFILVavpeslpekmrpaswgapisweqadPFASLRkVGQDST 256
Cdd:cd17503 128 VILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGI--LALLLA-------------------------PLLDLR-LFKDRN 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 257 VLLICITVFLSYLpeaGQYSSFF---LYLRQVIGFTSETVAAFIAVVGILSILAQTVVlGILMRSIGNKNTILLGL---G 330
Cdd:cd17503 180 FTLGLLLSFLLGL---GLFGAMFllpLYLQNVLGYSAFESGLVLAPGGLASAILSPLV-GRLLDKFGPRLLLLAGLlllA 255
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1916914340 331 FQILQLAWYGFGSQPWMMWAAGAVAAMS-SITFPAISAIVSRNADPDQQGVVQGMITGIRGLCNGLGPALYGFVFYLF 407
Cdd:cd17503 256 LGTLLLAFLTPDTSLWLIILPLFIRGLGmGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLLTNR 333
|
|
| MFS_CsbX |
cd17337 |
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ... |
86-410 |
7.48e-06 |
|
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 48.27 E-value: 7.48e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 86 GLIHGVKGLLSFLSAPLIGALSDVWG-RK-------SFLLLTVFFTCAPIPLMriSPWWYFAVISMSGV----FAVTFSV 153
Cdd:cd17337 35 ALLFTVYGLTVAIASWLSGVLAELFGpRRvmligliIWLVFEVLFLAFGLPSH--NYPLMLLTYGLRGFgyplFAYSFLV 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 154 IFAYVADitqEHERSTAYGLVSATFAASLvtsPAIGAYLSRA------YGDTL-----VVILATAIALLDI--CFILVAV 220
Cdd:cd17337 113 WITYRTP---AERLGSAVGWFWFAFTGGL---PVLGSYLASFtipvigEIGTLwlslvFVALGGLIALFLVrdRTGEQPL 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 221 PESLPEKMRPASWGAPISWEQadpfaslRKVGQDSTVLLICITV---FLSYLPeagqyssffLYLRQVIGFTSETVAAFI 297
Cdd:cd17337 187 ANPSEEPLKELLSGITILFRN-------PKIAIGGIVRIINTLSqfgFPVFMP---------LYFTDTGGFSTSQWLQIW 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 298 AVVGILSILAqTVVLGILMRSIGNKNTILL--GLGFQILQLAWY----GFGSQPWMMWAAGAVAAMSSITFPAISAIVSR 371
Cdd:cd17337 251 GIIFLVNIFF-NLIFGILGDKIGWRRTVRWfgGVGCAISTLLFYyvpqLFGHNYWAALIAAILFGIGLAGFVPLSALMPS 329
|
330 340 350
....*....|....*....|....*....|....*....
gi 1916914340 372 NAdPDQQGVVQGMITGIRGLCNGLGPALYGFVFYLFHVE 410
Cdd:cd17337 330 LA-PEHKGAAMSILNLGAGLSNFVGPAIVTLFLGSFGAG 367
|
|
| MFS_FBT |
cd17484 |
Folate-biopterin transporter of the Major Facilitator Superfamily of transporters; The ... |
101-334 |
8.53e-06 |
|
Folate-biopterin transporter of the Major Facilitator Superfamily of transporters; The Folate-biopterin transporter (FBT) family includes folate carriers related to those of trypanosomatids in higher plant plastids and cyanobacteria. FBT mediates folate monoglutamate transport involved in tetrahydrofolate biosynthesis. It also mediates transport of antifolates, such as methotrexate and aminopterin. The FBT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341037 [Multi-domain] Cd Length: 399 Bit Score: 47.99 E-value: 8.53e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 101 PLIGALSDVWG-----RKSFLLLTVFFTCAP---IPLMRISPWWYFAVISMSGVFAVTFS--VIFAYVADITQEHERSTA 170
Cdd:cd17484 50 PLYGLLSDSVPifgyrRKPYLILAGALGALSwlaLALVSNSSLALALLLLLLASLGVAFSdvVIDALVVEASRGAPQSLA 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 171 YGLVSaTFAASLVTSPAIGAYLSrAYGDTLV----VILATAIALLDICFILVAVPEslpekmrPASWGAPISWEQADPFA 246
Cdd:cd17484 130 GDLQS-LCWGSSAIGGIVGSYFS-GYLLELLgprtVFAVTSFFPLLLLIVAFFVKE-------ERVPPHRTKENFDEQLK 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 247 SLRKVGQDSTVLLICITVFLSY-LPEAGqySSFFLYLRQVIGFTSETVaAFIAVVGILSILAQTVVLGILMRSIGNKNTI 325
Cdd:cd17484 201 ALWETVKQPSIWLPALFIFLYQaTPSSG--SAMFYFMTNELGFSPEFL-GRLRVIGSIASLLGVLLYNRFLKHVPFRKIF 277
|
....*....
gi 1916914340 326 LLGLGFQIL 334
Cdd:cd17484 278 FWTTVLLVL 286
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
56-356 |
1.20e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 47.21 E-value: 1.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 56 FLEFFAWGLLTTPMLTVLHQTFPQHTFLMNGLIHGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMRISP- 134
Cdd:cd17316 9 FFDAYDFFLIGFVAPVLAAEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPt 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 135 -WWYFAVISMSGVF-AVTFSVIFAYVADITQEHERSTAYGLVSATFAASLVTSPAIGAYLSRAYGDTLvvilataiaLLD 212
Cdd:cd17316 89 pILLLVLRFLQGIGiGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDW---------GWR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 213 ICFILVAVPESLPEKMRPASWGAPISWeqadpfaslrkvgqdsTVLLICITVFLSYLPEagqyssfflYLRQVIGFTSET 292
Cdd:cd17316 160 ILFLIGALPALLALLLRRRTLLLILLW----------------FFISFGYYGLTTFLPT---------YLQTVLGLSPAT 214
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1916914340 293 VAAFIAVVGILSILAqTVVLGILMRSIGNKNTILLGLGFQILQLA--WYGFGSQPWMMWAAGAVAA 356
Cdd:cd17316 215 SSLYLLLISLGALVG-ALIAGLLSDRIGRKKTLVIGLILSGILALplFYLLSGSPTLLLLLLFILS 279
|
|
| MFS_AmpG_like |
cd17486 |
AmpG and similar transporters of the Major Facilitator Superfamily; AmpG acts as an inner ... |
95-403 |
1.74e-05 |
|
AmpG and similar transporters of the Major Facilitator Superfamily; AmpG acts as an inner membrane permease in the beta-lactamase induction system and in peptidoglycan recycling. It transports meuropeptide from the periplasm into the cytosol in gram-negative bacteria, which is essential for the induction of the ampC encoding beta-lactamase. The AmpG family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341039 [Multi-domain] Cd Length: 387 Bit Score: 46.82 E-value: 1.74e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 95 LSFLSAPLIGALSDVW--GRKSFLLLTVF-FTCAPIPLMRISPWWYFaVISMSGVFAVTFS------VIFAYVADITQEH 165
Cdd:cd17486 45 LKFLWAPLVDRYSTPFlgRRRGWILLTQIlLMAALIALAFLDPFTNL-VLSALLFLLVAFFsatqdiAIDAYRIEALEDK 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 166 ERSTAYGLVSATFAASLVTSPAIGAYLSRAYGDTLVVILATAIALLDICFILVAvpeslPEKMRPASWGAPISWEQADPF 245
Cdd:cd17486 124 EQGAGAGVRVNGYRIGMLVAGAGALYLADSLSWSAVYLIMAALMGPGILATLFA-----PEPPRTDPPANSLSETVVAFF 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 246 ASLRKVGQDSTVLLICITVFLSYLPEA--GQYSSFFlYLRqvIGFTSETVAAFIAVVGILSILAQTVVLGILMRSIGNKN 323
Cdd:cd17486 199 APFKDFFGQPGALLILAFILLYKLGDAmlGAMATPF-LLD--LGFTKTEIGAVYKTVGLIATIVGGLLGGFLMSRLGLKR 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 324 TILLGLGFQ---ILQLAW-YGFGSQPWMMWAAGAVAAMSS-ITFPAISAIVSRNADPDQQGVVQGMITGIRGLCNGLGPA 398
Cdd:cd17486 276 SLWLFGILQalsNLGFIYlAHAGPNLTLLVAAVAVENFGGgLGTTAFVAYLMSLCNGEFTATQYALLSSLMALGRMVLGA 355
|
....*
gi 1916914340 399 LYGFV 403
Cdd:cd17486 356 PSGWL 360
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
257-407 |
1.75e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 46.79 E-value: 1.75e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 257 VLLICITVFLSYLPEAGqYSSFFLYLRQVIGFTSETVAAFIAVVGILSILAQtVVLGILMRSIGNKNTILLGLGFQILQL 336
Cdd:COG2271 12 LALLFLAYFLNYLDRSN-LSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQ-IPAGLLADRFGRRRVLAIGLLLWGLAT 89
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1916914340 337 AWYGFGSQPWMMWAA-GAVAAMSSITFPAISAIVSRNADPDQQGVVQGMITGIRGLCNGLGPALYGFVFYLF 407
Cdd:COG2271 90 LLFGFATSFWQLLLLrFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF 161
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
93-300 |
2.58e-05 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 46.48 E-value: 2.58e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 93 GLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMRISPWWYFAVISMsGVFAVTFSV----IFAYVADITQEHERS 168
Cdd:cd17393 44 GVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALAL-FLFGAANGAldvaMNAQGVAVERAYGRP 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 169 TAYGLvSATFAASLVTSPAIGAYLSRAYGDTLVVILATA-IALLDICFILVAVPESLPEKMRPASWGApisweqadpfAS 247
Cdd:cd17393 123 IMSSL-HAMWSLGGLAGALLGAAAIGAGVSPGVHLLAAAvLLLLAALVAIRALLPGTGEAAEDRPDGA----------GK 191
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 1916914340 248 LRKVGQDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIGFtSETVAAFIAVV 300
Cdd:cd17393 192 PGFLLPNRLLLLLGLLALAAALAEGAAADWSALYLRDVLGA-SAALAALGYAV 243
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
86-404 |
2.75e-05 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 46.40 E-value: 2.75e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 86 GLIHGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMRI--SPWWYFAVISMSGV-FAVTFSVIFAYVADIT 162
Cdd:COG2807 56 GLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLapSVALLLAGTALIGAgIAVGNVLLPGLIKRWF 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 163 QEHeRSTAYGLVSATFAASLVTSPAIGAYLSRAYGDTLVVILATAIALLDICFILVAVPESlpekmRPASWGAPISWeqa 242
Cdd:COG2807 136 PDR-VGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRR-----PAAAAAAPAAA--- 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 243 dpfaSLRKVGQDSTVLLICITVFLSylpeAGQYSSFF----LYLRQvIGFTSETVAAFIAVVGILSILAqTVVLGILMRS 318
Cdd:COG2807 207 ----SLRSLWRSPLAWLLTLFFGLQ----SLLYYAVVawlpPILRD-AGLSAATAGLLLSLFQLAGIPG-SLLVPLLADR 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 319 IGNKNTILLGLG-FQILQLAWYGFGSQPWMMWAAGAVAAMSSITFP-AISAIVSRNADPDQQGVVQGMITGIRGLCNGLG 396
Cdd:COG2807 277 LGDRRPLLLLLGlLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPlALTLIGLRARTPAEAAALSGMAQSVGYLLAALG 356
|
....*...
gi 1916914340 397 PALYGFVF 404
Cdd:COG2807 357 PLLVGALH 364
|
|
| MFS_YxiO_like |
cd17482 |
Bacillus subtilis YxiO, Listeria monocytogenes BtlA, and similar transporters of the Major ... |
86-358 |
3.30e-05 |
|
Bacillus subtilis YxiO, Listeria monocytogenes BtlA, and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis MFS-type transporter YxiO, and similar proteins including Listeria monocytogenes BtlA. The function of B. subtilis YxiO is still unknown, and L. monocytogenes BtlA is a putative secondary transporter involved in bile tolerance and general stress resistance. This family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341035 [Multi-domain] Cd Length: 362 Bit Score: 46.06 E-value: 3.30e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 86 GLIHGVKGLLSFLSAPLIGALSDVWGRK-----SFLLLTVFFTCApipLMRISP--WWYFAVISMSGVFAVTFSVIF--A 156
Cdd:cd17482 42 GYANSIASLVIALLAPILGAIADYSGRKkrflaFFCLIGVVSTAL---LFFVTPgqWLLALLLFILANIGFSGANVFydA 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 157 YVADITQEHERstayGLVSAT-FAASLVTS--PAIGAYLSRAYGDTLVVILATAIallDICFILVAVpeslpekmrpaSW 233
Cdd:cd17482 119 FLPDVASPERM----DRVSSLgYALGYIGGglLFAVNLVLILGPDAFGLDTAEAV---RLSFLSVAL-----------WW 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 234 GApisweqadpFASLRKvgqdstVLLICITVFLSYLPEAGQYSSF-FLYLRQVIGFTSETVAAFIAVVGILSILAqTVVL 312
Cdd:cd17482 181 AL---------FSIPLK------QLLLFLIAYFFYIDGVQTIIRMaTIYGAEEGKLGSSALILALLLTQFVAFPG-ALLF 244
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 1916914340 313 GILMRSIGNKNTILLGLGFQILQLAWYGFGSQPWMMWAAGAVAAMS 358
Cdd:cd17482 245 GWLAERFGAKRAILVSLVIYILICIYAYFMLTAWDFWILAALIGLV 290
|
|
| Nuc_H_symport |
pfam03825 |
Nucleoside H+ symporter; |
53-404 |
5.20e-05 |
|
Nucleoside H+ symporter;
Pssm-ID: 461066 [Multi-domain] Cd Length: 399 Bit Score: 45.53 E-value: 5.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 53 VVIFLEFFAWGLLTTPMLTVLHQTFpqHTFLMNGLIHGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMRI 132
Cdd:pfam03825 9 VMMFLQFFIWGAWLVTLGSYMFVTG--FDGASIGAVYSSLGIAAIFMPALLGIIADRWFSAERVLAVCHLIGAITLFMAA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 133 S---PWWYFAVI---SMSGV--FAVTFSVIFAYVADITQEHERSTAYGLVsATFAASLVTSPAIGAYLSraYGDTLVVIL 204
Cdd:pfam03825 87 QvttFEAFFLVIlvnSLAYMptLALTNSIAFANLQDPVTDFPPIRVWGTI-GWIMASWPFVMWVVSLAG--FELSHMQLL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 205 ATAIAlldiCFILVAVPESLPEKmrPASWGAPISWEQA---DPFASLRkvgqDSTVLLICITVFLSYLPEAGQYSSFFLY 281
Cdd:pfam03825 164 IAAGL----SALLVLFALTLPHT--PAKQKANQSWTTLlglDAFALLK----NKRMAVFFIFSFLLGAELQIYNVFANTF 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 282 LRQVIGFTSETvAAFIAVVGILSILAQTVVLGILMRSIGNKNTILLGLGFQILQLAWYGFGSQPWMMWAAGAVAAMS--- 358
Cdd:pfam03825 234 LTSFDKFIVKH-ASIIMSLGQISEILFMLTLPFFLKRFGIKNVMLIGIVAWALRFAFFAYGADPTPFGTALLLLSMIvhg 312
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1916914340 359 ---SITFPAISAIVSRNADPDQQGVVQGMITgirGLCNGLGPALYGFVF 404
Cdd:pfam03825 313 vayDFFNITGYIFVDKEVPPAIRASAQGLFL---LMTNGFGCILGSILS 358
|
|
| MFS_MFSD6L |
cd17479 |
Major facilitator superfamily domain-containing protein 6-like and similar transporters of the ... |
81-407 |
7.72e-05 |
|
Major facilitator superfamily domain-containing protein 6-like and similar transporters of the Major Facilitator Superfamily; Major facilitator superfamily domain-containing protein 6-like (MFSD6L) protein family includes a group uncharacterized proteins similar to human major facilitator superfamily domain-containing protein 6 (MFSD6). MFSD6 is also called Macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. The MFSD6L family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341032 [Multi-domain] Cd Length: 376 Bit Score: 44.99 E-value: 7.72e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 81 TFLMNGLIHGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLmriSPWWYFAVISMSGVFAVTFSVIFAYVAD 160
Cdd:cd17479 29 TAPQVGIIIGSKHLISLLWAPFWSFLAKSYRKRRFVILFSLLISLGTYL---LYHQIFLLVLLVIIIWELLSAPLEKVAD 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 161 -----------ITQEHERSTAYGLVSATFAASLVT----------SPAIGAYLSRAYGDTLVVILATaiaLLDICFilva 219
Cdd:cd17479 106 dslyeyldfvdATERYGKLKVWSALGAAFGPCGITllvdnldcflPPKISRILLHFYTYGGFMILTF---LLSFFY---- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 220 vPESLPEKMRPASWGapisweqadpFASLRKVGQDSTVLLICITVFLSYLPeAGQYSSFFLYLRQVIGFTSETVAAFIAV 299
Cdd:cd17479 179 -PIPVPKKEEHSSKV----------VKGLRLLGGDGRAILYALTVFLVGFV-GSTVQNFLFWLMQDKGGSELHMGLSIAL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 300 vGILSILAQTVVLGILMRSIGNKNTILLGLGFQILQLAWYGFGSQPwmmWAAGAVAAMSSITFPAI-SAIVSRNADPDQQ 378
Cdd:cd17479 247 -ALLSEILMSFFGNWLLRKLGHAGCVVLGLLGLGAQLLYYSFLWTP---WAVLPIELLHAFSNGALwWAVNSQVEFLASP 322
|
330 340
....*....|....*....|....*....
gi 1916914340 379 GVVQGMITGIRGLCNGLGPALYGFVFYLF 407
Cdd:cd17479 323 GMERSLQLVLRALYYGIGFALGSFVSGFI 351
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
60-373 |
8.61e-05 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 44.93 E-value: 8.61e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 60 FAWGLLTTPMLTVLHQTFPQHTFLmnGLIHGVKGLLSFLSAPLIGALSDV----WG-RKSFLLLTVFFTCAPIPLMRISP 134
Cdd:cd17313 13 FGWALENSYVPPILQTLGLSHALI--GFVWTLGPILGLFVQPLVGSLSDRcnsrIGrRRPFILVGAPLAALGLILIPNAA 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 135 WWYFAVISMSGVFAVTFSVIF----------------AYVADITQEHERSTAYGLVSATFAASLVTSPAIGAYLS----- 193
Cdd:cd17313 91 DIGLALGDGPRTWALVLFVLGivlldfamnvcqgpvrALLPDLVPPEQRSKANGIINFMGGLGGVLGYLLGAILWdhnwf 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 194 -RAYGDTLVVILATAIALLDICFI--LVAVPEslpEKMRPASWGAPISWEQADPFASLRKV--GQDSTVLLICITVFLSY 268
Cdd:cd17313 171 gFALGGNLKVPFYIGAIILLVCVLvtLFFVKE---PPLSPEAGEHSENPSLGEVLKSLLKLlkIMPRSLLRLLLVIFFWW 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 269 LpeAGQYSSFF--LYLRQVIGFT----------SETVAAFIAVVGILSILAQTVVLGILMRSIGNKNTILLGLGFQILQL 336
Cdd:cd17313 248 I--AFFPFELFftDYMGEEVYHGtsaasshygaGVRMGAWGLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGM 325
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1916914340 337 AWYGFGSQPW----MMWAAGAV-AAMSSITFPAISAIVSRNA 373
Cdd:cd17313 326 ALMALVHNVTvalvLFALGGIGwATININPYPLVSDYHSESG 367
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
52-217 |
1.26e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 44.34 E-value: 1.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 52 VVVIFLEFFAWGLLTTPMLTVLHQTFPQHTFLMnGLIHGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAP---IP 128
Cdd:cd06174 209 LLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVA-GLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALglaLL 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 129 LMRISPWWYFAVISMSGVFAVTFS-VIFAYVADITQEHERSTAYGLVSAT-FAASLVTSPAIGAYLSRAYGDTLVVILAT 206
Cdd:cd06174 288 LLAPSLLLLLLLLLLLGFGLGGLLpLSFALIAELFPPEIRGTAFGLLNTFgFLGGAIGPLLAGFLLAATFGLTGAFLVLA 367
|
170
....*....|.
gi 1916914340 207 AIALLDICFIL 217
Cdd:cd06174 368 VLLLLAAILLL 378
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
46-211 |
1.37e-04 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 44.08 E-value: 1.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 46 PSVYHAVVVIFLEFFAWGLLTTPMLTVLHQTFPQHTFLMNGLIhGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCA 125
Cdd:cd17324 198 PRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLL-LLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAA 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 126 PIPLMRISPWWYFAVISM---SGVFAVTFSVIFAYVADITQEHeRSTAYGLVSATFAASLVTSPAIGAYLSRAYGDTLVV 202
Cdd:cd17324 277 LLLLTLLGPSPLLLLVGLvlwGLGFFAAHSALQTRVLRLAPEA-RGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVG 355
|
....*....
gi 1916914340 203 ILATAIALL 211
Cdd:cd17324 356 WVGAALLLL 364
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
51-211 |
2.21e-04 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 43.67 E-value: 2.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 51 AVVVIFLEFFAWGLLTTPMLTVLHQT--FPQHTFLMNGLIHGVkglLSFLSAPLIGALSDVWGRKS-FLLLTVFFTCAPI 127
Cdd:cd17369 233 AIGLRLAENVLFYLFTTFALSYATQTlgVDRSTVLLAVLIASV---VAAITIPLFGWLSDRVGRRPvYLAGALLAALFAF 309
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 128 PLM-----RISPWWYFAVISMSGVF-AVTFSVIFAYVADITQEHERSTAYGL---VSATFAASLVtsPAIGAYLSRAYGD 198
Cdd:cd17369 310 PFFwlldtGSTWLIVLAAVVVLGVLhGMMYGPQAAFLAELFPTRVRYTGASLgyqLGAILGGGFA--PLIATALVAATGS 387
|
170
....*....|....*..
gi 1916914340 199 T----LVVILATAIALL 211
Cdd:cd17369 388 WwpvaLYLAALAVISLV 404
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
94-399 |
5.50e-04 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 42.17 E-value: 5.50e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 94 LLSFLSAPLIGALSDVWGRKSFLLL-TVFFT-----CApipLMRISPWWYFAV----ISMSGVFAVTFSVIfayvADITQ 163
Cdd:cd17502 41 LTSTAFQPIYGKLSDLFGRKWVLLIaIVIFElgsllCG---LAPNMTMLIVGRaiqgIGGGGLMSLAFIII----ADLVP 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 164 EHERSTAYGLVSATFAASLVTSPAIGAYLSRAYGDTLVVILATAIALLDICFIlvavpeslpekmrpaswgapisweqad 243
Cdd:cd17502 114 PRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIGGLALALL--------------------------- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 244 pfaslrkvgqdSTVLLICITVFLSYlpeAGQYSSFF---LYLRQVIGFtSETVAAFIAVVGILSILAQTVVLGILMRSIG 320
Cdd:cd17502 167 -----------RTILLSSIFGFLFG---GALFGLIYylpLYFQLVLGD-SATKSGVRLLPLIIGLVIGSIISGALISKTG 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 321 N-KNTILLGLGFQI---LQLAWYGFGSQPWMMWAAGAVAAMSS-ITFPAISAIVSRNADPDQQGVVQGMITGIRGLCNGL 395
Cdd:cd17502 232 RyKPLIVIGTILMSvgaGLLTTLTLDTSKWLLIGYLILLGLGLgIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTL 311
|
....
gi 1916914340 396 GPAL 399
Cdd:cd17502 312 GVAI 315
|
|
| MFS_SLC46A1_PCFT |
cd17449 |
Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major ... |
94-406 |
6.41e-04 |
|
Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major Facilitator Superfamily of transporters; Solute carrier family 46 member 1 (SLC46A1) is also called proton-coupled folate transporter (PCFT), G21, or heme carrier protein 1 (HCP1). It functions in two ways: as an intestinal proton-coupled high-affinity folate transporter that facilitates the absorption of folates across the brush-border membrane of the small intestine; and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. It displays a higher affinity for folate than heme. It is also expressed in the choroid plexus and is required for transport of folates into the cerebrospinal fluid. Loss of function mutations in the SLC46A1 gene results in the autosomal recessive disorder "hereditary folate malabsorption" (HFM), characterized by severe systemic and cerebral folate deficiency. SLC46A1 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341007 [Multi-domain] Cd Length: 425 Bit Score: 42.10 E-value: 6.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 94 LLSFLSAPLIGALSDVWGRKSFLLLTVFFTC--APIPLMRIS---PWWYFAV----ISMSGVFAVTFSVIFAYVADITQE 164
Cdd:cd17449 76 LVGLFSVTLLGPWSDSVGRRPVLILPSLGLAlqAAVYLLVMYlqlHVAYFLIgrilSGLLGDFNGILAGCFAYVADVSDR 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 165 HERSTAYGLVSATFAASLVTSPAIGAYLSRAYGDTLVVILATAIALLDICFILVAVPESLPEK--MRPASWGAPISWEQ- 241
Cdd:cd17449 156 RSRTFRVAVLEACLGLAGMLASIIGGQWRKAQGYINPFWLVLALNLAAALYAAFCVGESVKEPksARLFTTRHHQSVVRl 235
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 242 ---ADPFASLRKVGQDSTVLLICITVFLsylpeaGQYSSFFLY-LRQVIGFTSETVaAFIAVVGILSILAQTVVLGILMR 317
Cdd:cd17449 236 yvaPAPNGSRRKLALYSLALFVVVTVHF------GAKDLLVLYeLSSPLCWDSDLI-GYGSAAEHLTYLSSLLGLRLLQL 308
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 318 SIGNKNTILLGLGFQILQLAWYGFGSQPWMMWAAGAVAAMSSITFPAISAIVSRNADPDQQGVVQGMITGIRGLC----- 392
Cdd:cd17449 309 CLEDTWVAEIGLISNISGLVVISVATTTPLMFTGYGLLFLSMATTPVIRAKLSKLVRETEQGALFASVACVEGLCslvat 388
|
330 340
....*....|....*....|.
gi 1916914340 393 ---NGLGPA----LYGFVFYL 406
Cdd:cd17449 389 gifNSLYPAtlhfMKGFPFLF 409
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
56-404 |
7.56e-04 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 41.92 E-value: 7.56e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 56 FLEFFAWGL---LTTPMLTVLHQTFPQHTFLMnGLIHGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMRI 132
Cdd:cd17333 2 YISFFSNGLtdaLLGILGPSLEEAFNLNVADV-SVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 133 SPWWYFAVISM------SGVF--AVTFSVIFAYvaditqEHERSTAYGLVSATFAASLVTSPAIGAYL-------SRAYg 197
Cdd:cd17333 81 TPSIYLFVVLMflaglgAGILdtGANTFVGALF------EESSATRLNVLHGFFGLGALIGPLIATSLltselswSWAY- 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 198 dtlVVILATAIALLdICFILVAVPESLPEKMRPASWGApiswEQADPFASLRKVGqdstVLLICITVFLSYLPEAGQYSS 277
Cdd:cd17333 154 ---LIIGLIYLLLA-ILILLTLFPELPSARNPQQSVGA----FSASASRLLRNPS----IILGALALFLYVGAETAFSSW 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 278 FFLYLRQVIGfTSETVAAFIAVVGILSILAQTVVLGILMRSIGNKNTILL-GLGFQILQLAWYGFGSQPWMMWAAGAVAA 356
Cdd:cd17333 222 VPSYLVEKKH-VSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHTLLVLsGSGALLGLLILLLAPTLVVGLVATALLGL 300
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1916914340 357 MSSITFPAISAIVSRNAdPDQQGVVQGMITGIRGLCNGLGPALYGFVF 404
Cdd:cd17333 301 FMAALFPTILSLGISNL-PYAKGKGTSVLLAAGSIGGAIIPFIMGFIA 347
|
|
| MFS_MFSD3 |
cd17485 |
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ... |
94-403 |
2.02e-03 |
|
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341038 [Multi-domain] Cd Length: 386 Bit Score: 40.29 E-value: 2.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 94 LLSFLSAPLIGALS--DVWGRKSFLLLTVFFTCAPIPLM-----RISPWWYFAVISMSGVFAVTFSV-IFAYVADITQEH 165
Cdd:cd17485 45 VLKFLWAPLVDRYGlpRLGRRRSWLLPTQLGLALLLLALaflppTTNLLAFLGLLFLLNLFSATQDIaTDGLAVELLTPE 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 166 ERSTAYGLVSATFAASLVTSPAIGAYLSRAYGDTLVVILATAIALLDICFILvavpeSLPEKMRPAswGAPISWEQADPF 245
Cdd:cd17485 125 ERGLGNAAQVVGYKLGSLLGGGGLLWLYDLIGWQSLLLSLAALYLLLLLPVL-----FLRELELPQ--QPPASERGAALK 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 246 ASLRKVGQDSTVLLICITVFLSYLPEAGQYSSFFLYLRQViGFTSETVAAFIAVVGILSILAQTVVLGILMRSIGNKNTI 325
Cdd:cd17485 198 ASLRAFLRRPGTRWLLLFLLLYKLGEQGALAMLPPFLVDR-GFSLSQIGLLSGVGGSLVSIAGSLLGGYLLKRRGRRRLL 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 326 LLGLGFQ-ILQLAWYGFGSQPWMMWAAGAVAAM------SSITFPAISAIVSRNADPDQQGVVQGMITGIRGLCNGLGPA 398
Cdd:cd17485 277 LLGGLLRlLLLGLYTLLALGGSGLNWVLLLASLallhlvGGMITTALFTLMMDCSQQAQAGTDYTLLATVEVLGKLLFGS 356
|
....*
gi 1916914340 399 LYGFV 403
Cdd:cd17485 357 LAGFL 361
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
60-218 |
2.12e-03 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 40.25 E-value: 2.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 60 FAWGLLTTPMLTVLHQTFpQHTFLMNGLIHGVKGLLSFLSAPLIGALSD---VWGRKSFLLLTVFFTCAPIPLMRI--SP 134
Cdd:cd17319 193 YALYGLLTWLPTYLKQAR-GFSLKQVGLLAAIPFLAGAIGMILGGRLSDrllRGARRLVIIIGLLLAAVGLLLAYLttSP 271
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 135 WWYFAVISMSGVFA-VTFSVIFAYVADITQEHERSTAYGLVSATFA-ASLVTSPAIGAYLSRAYGDTLVVILATAIALLD 212
Cdd:cd17319 272 VVAVILLSLAGFGIgAASPVFWSLPADLLPGEAAATAGGLINSGGNlGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLA 351
|
....*.
gi 1916914340 213 ICFILV 218
Cdd:cd17319 352 ALLVLL 357
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
86-219 |
2.36e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 40.23 E-value: 2.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 86 GLIHGVKGLLSFLSAPLIGALSDVWGRKSFLL---LTVFFTCAPIPLMRISPWWYFAVISMSGVFAVT-FSVIFAYVADI 161
Cdd:cd17477 226 ALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLgcaLLGALAALLLPLVPGLPLALLVLLFLWGGAAGPlYTLALALAGDR 305
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1916914340 162 TQEHERSTAYGLVSATFAASLVTSPAIGAYLSRAYGDTLvviLATAIALLDICFILVA 219
Cdd:cd17477 306 LPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHG---LFLFLAAVALLFLLFL 360
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
51-400 |
2.42e-03 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 40.29 E-value: 2.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 51 AVVVIFLEFFAWGLLTTPMLTVLHQTFPQHTFLMNGLIhgvkgLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLM 130
Cdd:cd17353 11 LMHLILGYQYAWSVFNPPLSSALGWSLASVALAFTLTI-----VFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILS 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 131 RISPWWYFAVISMSGVFAVTFSVIFAYVADITQ---EHERSTAYGLVSATFA-ASLVTSPAIGAYL-SRAYGDTLVVILA 205
Cdd:cd17353 86 AFAISLPLLFLGYGVLGGIGAGIGYITPVSTAVkwfPDKRGLATGIVIAGFGlGSLIFSPLIAYLInTVGVPTTFLILGI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 206 TAIALLDICFILVAVPeslPEKMRPASWGAP-ISWEQADPFASLRKVGQDSTVLLICITVFLSYLPEAGQYSSFFLYLRQ 284
Cdd:cd17353 166 IFLIIIVIGAFLIRDP---PKGWVPPGVDPLaNNAENSPRDYTPREMLRTPTFWLLWLMFFLNATAGLMLIGQAKPIGQE 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 285 VIGFTSETVAAFIAVVGILSILAQtVVLGILMRSIGNKNTILLGLGFQIL-QLAWYGFGSQPWM-MWAAGAVAAMSSITF 362
Cdd:cd17353 243 FAGLDAGIAALAVSILSIFNGGGR-PFWGWLSDKIGRKNTLSIAFLIQGVaMFLLPFIGSVAVLfVLGVALIGFCYGGGF 321
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1916914340 363 PAISAIVSRNADPDQQGVVQGMI---TGIRGLCNGLGPALY 400
Cdd:cd17353 322 ALFPALTADFFGTKNAGTNYGLLytaKGVGGLIGPIIAAYV 362
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
93-211 |
2.55e-03 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 40.36 E-value: 2.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 93 GLLSFLSAPLIGALSDVWGRKSFLL-LTVFFTCAPIPLMRI-----SPWWYFAVISMSGVFAVTFSVIFAYV-ADITQEH 165
Cdd:cd17367 269 LLVFMLLQPLGGRLSDRIGRRPLLLfFGIGGTLATVPLLSAldhtdSPYTAFALVLVGLVFLSGYTSINAVVkAELFPTH 348
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 1916914340 166 ERST----AYGLVSATFAAslvTSPAIGAYLSRAYGDTLVVILATAIALL 211
Cdd:cd17367 349 VRALgvglPYALAVAIFGG---TAPYVALWLKSIGHEWVFFWYVAGLIAI 395
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
97-223 |
3.82e-03 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 39.61 E-value: 3.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 97 FLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMRISP-WWYFAVI-SMSGVFAVTFSVI-FAYVADITQEHERSTAYGL 173
Cdd:TIGR00898 141 LLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPnYTVFLVFrLLVGMGIGGIWVQaVVLNTEFLPKKQRAIVGTL 220
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 1916914340 174 VSATFAASLVTSPAIgAYLSRAYGDTLVVILATAIALLDICFIlvaVPES 223
Cdd:TIGR00898 221 IQVFFSLGLVLLPLV-AYFIPDWRWLQLAVSLPTFLFFLLSWF---VPES 266
|
|
| MFS_NHS |
cd06177 |
Nucleoside:H(+) symporter family of the Major Facilitator Superfamily of transporters; The ... |
53-404 |
4.65e-03 |
|
Nucleoside:H(+) symporter family of the Major Facilitator Superfamily of transporters; The prototypical members of the Nucleoside:H(+) symporter (NHS) family are Escherichia coli nucleoside permease NupG and xanthosine permease. Nucleoside:H(+) symporters are proton-driven transporters that facilitate the import of nucleosides across the cytoplasmic membrane. NupG is a broad-specificity transporter of purine and pyrimidine nucleosides. Xanthosine permease is involved in the uptake of xanthosine and other nucleosides such as inosine, adenosine, cytidine, uridine and thymidine. The NHS family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340866 [Multi-domain] Cd Length: 386 Bit Score: 39.15 E-value: 4.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 53 VVIFLEFFAWG----LLTTPMLTVLHQTFPQHtflmnGLIHGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIP 128
Cdd:cd06177 4 VMMFLQFFIWGawlvTLGGYMGSTLGFTGAQI-----GAVYSTTGIAAIIMPFFLGIIADRFFAAEKVLAVLHLIGAAAL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 129 LM---RISPWWYFAVI---SMSGV--FAVTFSVIFAYVADITQEHERSTAYGLVsATFAASLvtspAIGAYLSRAYGDTL 200
Cdd:cd06177 79 FYaatVTDFSVFFWVMllySLCYMptLALTNSIAFSNLEDPVKDFPPIRVWGTI-GWIAAGW----PVGFLGWEASNLQF 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 201 VVILATAIALLDICFILVAVPeslpekmrPASWGAPISWEQA---DPFASLRkvgqDSTVLLICITVFLSYLPEAGQYSS 277
Cdd:cd06177 154 YIAAGASLLLGLYSLTLPHTP--------PKKAGKGVSKRSLlglDAFVLLK----NPFFAVFFIFSFLLGAPLQFYYTF 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 278 FFLYLRQViGFTSETvAAFIAVVGILSILAQTVVLGILMRSIGNKNTILLGLGFQILQLAWYGFGSQP---WMMWAAGAV 354
Cdd:cd06177 222 ANPFLNDF-GMIVKN-PAGIMSLGQISEILFMLAIPFFLKRLGIKKVMLIGMLAWVLRFGLFAYGDPSpgvWMLVLSIIL 299
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1916914340 355 AAMSSITFPAISAI-VSRNADPDQQGVVQGMITgirGLCNGLGPALYGFVF 404
Cdd:cd06177 300 HGVCYDFFFVTGYIyVDKKAPKDIRASAQGLFM---LMTNGVGALVGSILS 347
|
|
| MFS_MFSD8 |
cd17326 |
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ... |
86-407 |
8.11e-03 |
|
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340884 [Multi-domain] Cd Length: 374 Bit Score: 38.34 E-value: 8.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 86 GLIHGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLM-----RISPWWYFAVIS---MSGVFAVTFSVIFAY 157
Cdd:cd17326 39 GWVVAAYSLGQLVFSPVFGYWSNKTSSVKEPLIVSILIAIVGNILyalaeYFPSNRKYVMLVarfLIGVGAGNVAVLRAY 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 158 VADITQEHERSTAYGLVSATFAASLVTSPAIGAYLSRAyGDTLVVI--------------LATAIALLDICFILVAVPEs 223
Cdd:cd17326 119 VAAASTLKDRTRAMAVISAAQALGFIVGPALQAAFTPI-GYPGYVIgiklrfnmytapawLMAILGIINIILILFFFKE- 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 224 lpekmrpaswgapisweqadpfaslrkvgqdstvlLICITV-FLSYLPEAGQYSSFFLYLRQVIGFTSE----TVAAFIA 298
Cdd:cd17326 197 -----------------------------------VVCIFLfFVVLFIFANLETIGTPLTMDMYGWTREeavlYNGIILA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 299 VVGILSILAQTVVLGILMRSIGNKNTILLGLGFQILQLAWYgfgsqpwMMWAAGAVAAMsSITFPAIS----AIVSRNAD 374
Cdd:cd17326 242 VSGVLSVLVFLLFKFLSLGLIDERKILLGGLILFFLGFVVT-------LPWGITGVILF-GLGYPIGNvmlyTLYSKILG 313
|
330 340 350
....*....|....*....|....*....|...
gi 1916914340 375 PDQQGVVQGMITGIRGLCNGLGPALYGFVFYLF 407
Cdd:cd17326 314 PKPQGTMQGVLTASGSLARTLGPIFVTAIYTHF 346
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
85-218 |
8.37e-03 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 38.35 E-value: 8.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 85 NGLIHGVKGLLSFLS-APLIGALSDVWGRKSFLLLTVFFTCAPIPLMRI--SPWWYFAVIsmsgVFAVTFSVIFAYVAD- 160
Cdd:cd17331 245 NGYLMSYAGVLGMVVqGLLVGPLTKRFGERSLLKLSVALLAIGYLLLAFvtTVWQLLVLL----LPLVIGGSVLYTVITs 320
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1916914340 161 -ITQ---EHERSTAYGLVSATFAASLVTSPAIGAYLSRAYGDTLVVILATAIALLDICFILV 218
Cdd:cd17331 321 lLTKavpPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGFPSFGLLGAAINGLLTVYLLL 382
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
53-220 |
8.91e-03 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 38.55 E-value: 8.91e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 53 VVIFLEFFAWGLLTTPMLTVLHQTFPQHTFLMNGLIhGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFF-----TCAPI 127
Cdd:cd17314 213 IAIFLVLIGGFLFIANMASLVRSLQLDAPSFVTKLM-SIYGLFNAFGRLLWGIVADFFGGRLSTLSILLTilglgLCAFL 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916914340 128 PLMRISPWWYFAVISMSG-VFAVTFSVIFAYVADITQEHERSTAYGLVSATFAASLVTSPAIGAYLSRAYGDTLVVILAT 206
Cdd:cd17314 292 FLLKMTPVGLVLTGSLLGfSYGGLFTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDRTPSYISAVYIY 371
|
170
....*....|....
gi 1916914340 207 AIALLDICFILVAV 220
Cdd:cd17314 372 AVIVFLASAILLAV 385
|
|
| |
