|
Name |
Accession |
Description |
Interval |
E-value |
| GadA |
COG0076 |
Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport ... |
56-501 |
2.74e-144 |
|
Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport and metabolism]; Glutamate or tyrosine decarboxylase or a related PLP-dependent protein is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis
Pssm-ID: 439846 [Multi-domain] Cd Length: 460 Bit Score: 421.93 E-value: 2.74e-144
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799942 56 QPPEQLRQLLDLEMRDTGESQDKLLK-LCQDVIRYSVKTNHPRFFNQLYAGLDYHSLAARIITEALNPSIYTYEVSPVFL 134
Cdd:COG0076 27 PSPEELRAALDEPLPEEGLPPEEALAeLEDLVLPGSVDWNHPRFLAFVTGGTTPAALAADLLASALNQNMGDWDTSPAAT 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799942 135 LVEEAVLKKMIECVGWKEG-DGIFNPGGSVSNMCAMNLARYRHCP-DIKDKGLSGLPRLILFTSAECHYSMKKAASFLGI 212
Cdd:COG0076 107 ELEREVVRWLADLLGLPEGaGGVFTSGGTEANLLALLAARDRALArRVRAEGLPGAPRPRIVVSEEAHSSVDKAARLLGL 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799942 213 GTQNVYFVETDGRGKMIPEELEKQIWQGKQEGAVPFLVCATSGTTVLGAFDPLDEIAEVCERHGLWLHVDASWGGSALVS 292
Cdd:COG0076 187 GRDALRKVPVDEDGRMDPDALEAAIDEDRAAGLNPIAVVATAGTTNTGAIDPLAEIADIAREHGLWLHVDAAYGGFALPS 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799942 293 RKHRRLLHGIHRADSVAWNPHKMLMAGIQCSALLVKDKsDLLKKCYSAKATYLFQQDkfyDVSYDTGDKSIQCSRRPDAF 372
Cdd:COG0076 267 PELRHLLDGIERADSITVDPHKWLYVPYGCGAVLVRDP-ELLREAFSFHASYLGPAD---DGVPNLGDYTLELSRRFRAL 342
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799942 373 KFWMTWKAVGTSGLEERVNRAFALSRYLVDEIKKREGFKLLIEPEYTNVCFWYIPPSLREMAEGPEFWRklslvapaikE 452
Cdd:COG0076 343 KLWATLRALGREGYRELIERCIDLARYLAEGIAALPGFELLAPPELNIVCFRYKPAGLDEEDALNYALR----------D 412
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 1958799942 453 KMMKKGSLMLGYQPHRGKVNfFRQVVISPQVSREDMDFLLDEIDSLGRD 501
Cdd:COG0076 413 RLRARGRAFLSPTKLDGRVV-LRLVVLNPRTTEDDVDALLDDLREAAAE 460
|
|
| DOPA_deC_like |
cd06450 |
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
98-498 |
2.32e-122 |
|
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and glutamate decarboxylase (GDC). DDC is active as a dimer and catalyzes the decarboxylation of tyrosine. GDC catalyzes the decarboxylation of glutamate and HDC catalyzes the decarboxylation of histidine.
Pssm-ID: 99743 [Multi-domain] Cd Length: 345 Bit Score: 361.52 E-value: 2.32e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799942 98 FFNQLYAGLDYHSLAARIITEALNPSIYTYEVSPVFLLVEEAVLKKMIECVGW--KEGDGIFNPGGSVSNMCAMNLARYR 175
Cdd:cd06450 1 FLAGFVTTMDPPALLLEMLTSAKNAIDFTWDESPAATEMEAEVVNWLAKLFGLpsEDADGVFTSGGSESNLLALLAARDR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799942 176 HCPDIKDKGLSGLPRLILFTSAECHYSMKKAASFLGIgtqNVYFVETDGRGKMIPEELEKQIWQGKQEGAVPFLVCATSG 255
Cdd:cd06450 81 ARKRLKAGGGRGIDKLVIVCSDQAHVSVEKAAAYLDV---KVRLVPVDEDGRMDPEALEAAIDEDKAEGLNPIMVVATAG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799942 256 TTVLGAFDPLDEIAEVCERHGLWLHVDASWGGSALVSRKHRRLLHGIHRADSVAWNPHKMLMAGIQCSALLVKdksdllk 335
Cdd:cd06450 158 TTDTGAIDPLEEIADLAEKYDLWLHVDAAYGGFLLPFPEPRHLDFGIERVDSISVDPHKYGLVPLGCSAVLVR------- 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799942 336 kcysakatylfqqdkfydvsydtgdksiqcsrrpdAFKFWMTWKAVGTSGLEERVNRAFALSRYLVDEIKKREGFKLLIE 415
Cdd:cd06450 231 -----------------------------------ALKLWATLRRFGRDGYGEHIDRIVDLAKYLAELIRADPGFELLGE 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799942 416 PEYTNVCFWYIPPSlremaegpefwrKLSLVAPAIKEKMMKKGSLMLGYQPHRGKvNFFRQVVISPQVSREDMDFLLDEI 495
Cdd:cd06450 276 PNLSLVCFRLKPSV------------KLDELNYDLSDRLNERGGWHVPATTLGGP-NVLRFVVTNPLTTRDDADALLEDI 342
|
...
gi 1958799942 496 DSL 498
Cdd:cd06450 343 ERA 345
|
|
| Pyridoxal_deC |
pfam00282 |
Pyridoxal-dependent decarboxylase conserved domain; |
58-426 |
2.46e-120 |
|
Pyridoxal-dependent decarboxylase conserved domain;
Pssm-ID: 395219 Cd Length: 373 Bit Score: 357.50 E-value: 2.46e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799942 58 PEQLRQLLDLEMRDTGESQDKLLKLCQDVIRYSVKTNH-PRFFNQLYAGLDYHSLAARIITEALNPSIYTYEVSPVFLLV 136
Cdd:pfam00282 1 PGYLKPLLPLAAPIIPEPELQIDGDIRRNLMPGVTTWHsPHFHAYMPTGNSYPSLLGDMLTDAINCNGFTWESSPACTEL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799942 137 EEAVLKKMIECVGW------KEGDGIFNPGGSVSNMCAMNLARYRHCPDIKDKG-----LSGLPRLILFTSAECHYSMKK 205
Cdd:pfam00282 81 ENVVMNWLGEMLGLpaeflgQEGGGVLQPGSSESNLLALLAARTKWIKRMKAAGkpadsSGILAKLVAYTSDQAHSSIEK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799942 206 AASFLGIGtqnVYFVETDGRGKMIPEELEKQIWQGKQEGAVPFLVCATSGTTVLGAFDPLDEIAEVCERHGLWLHVDASW 285
Cdd:pfam00282 161 AALYGGVK---LREIPSDDNGKMRGMDLEKAIEEDKENGLIPFFVVATLGTTGSGAFDDLQELGDICAKHNLWLHVDAAY 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799942 286 GGSALVSRKHRRLLHGIHRADSVAWNPHKMLMAGIQCSALLVKDKSDlLKKCYSAKATYLFQQDKfydvSYDTGDKSIQC 365
Cdd:pfam00282 238 GGSAFICPEFRHWLFGIERADSITFNPHKWMLVLLDCSAVWVKDKEA-LQQAFQFNPLYLGHTDS----AYDTGHKQIPL 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958799942 366 SRRPDAFKFWMTWKAVGTSGLEERVNRAFALSRYLVDEIKKREGFKLLIEPEYTNVCFWYI 426
Cdd:pfam00282 313 SRRFRILKLWFVIRSLGVEGLQNQIRRHVELAQYLEALIRKDGRFEICAEVGLGLVCFRLK 373
|
|
| PLN02590 |
PLN02590 |
probable tyrosine decarboxylase |
58-427 |
1.36e-41 |
|
probable tyrosine decarboxylase
Pssm-ID: 178200 [Multi-domain] Cd Length: 539 Bit Score: 156.41 E-value: 1.36e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799942 58 PEQLRQLLDLEMRDTGESQDKLLK-LCQDVIRYSVKTNHPRFFNQLYAGLDYHSLAARIITEALNPSIYTYEVSPVFLLV 136
Cdd:PLN02590 92 PGYLRDMLPDSAPERPESLKELLDdVSKKIMPGITHWQSPSYFAYYASSTSVAGFLGEMLNAGLSVVGFTWLTSPAATEL 171
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799942 137 EEAVLKKMIECVGWKE-------GDGIFNPGGSVSNMCAMNLARYRhcpDIKDKGLSGLPRLILFTSAECHYSMKKAASF 209
Cdd:PLN02590 172 EIIVLDWLAKLLQLPDhflstgnGGGVIQGTGCEAVLVVVLAARDR---ILKKVGKTLLPQLVVYGSDQTHSSFRKACLI 248
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799942 210 LGIGTQNVYFVETDGRGK--MIPEELEKQIWQGKQEGAVPFLVCATSGTTVLGAFDPLDEIAEVCERHGLWLHVDASWGG 287
Cdd:PLN02590 249 GGIHEENIRLLKTDSSTNygMPPESLEEAISHDLAKGFIPFFICATVGTTSSAAVDPLVPLGNIAKKYGIWLHVDAAYAG 328
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799942 288 SALVSRKHRRLLHGIHRADSVAWNPHKMLMAGIQCSALLVKDKSDLLKKCYSAKATYLFQQDKfYDVSYDTGDKSIQCSR 367
Cdd:PLN02590 329 NACICPEYRKFIDGIENADSFNMNAHKWLFANQTCSPLWVKDRYSLIDALKTNPEYLEFKVSK-KDTVVNYKDWQISLSR 407
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799942 368 RPDAFKFWMTWKAVGTSGLEERVNRAFALSRYLVDEIKKREGFKLLIEPEYTNVCFWYIP 427
Cdd:PLN02590 408 RFRSLKLWMVLRLYGSENLRNFIRDHVNLAKHFEDYVAQDPSFEVVTTRYFSLVCFRLAP 467
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| GadA |
COG0076 |
Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport ... |
56-501 |
2.74e-144 |
|
Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport and metabolism]; Glutamate or tyrosine decarboxylase or a related PLP-dependent protein is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis
Pssm-ID: 439846 [Multi-domain] Cd Length: 460 Bit Score: 421.93 E-value: 2.74e-144
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799942 56 QPPEQLRQLLDLEMRDTGESQDKLLK-LCQDVIRYSVKTNHPRFFNQLYAGLDYHSLAARIITEALNPSIYTYEVSPVFL 134
Cdd:COG0076 27 PSPEELRAALDEPLPEEGLPPEEALAeLEDLVLPGSVDWNHPRFLAFVTGGTTPAALAADLLASALNQNMGDWDTSPAAT 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799942 135 LVEEAVLKKMIECVGWKEG-DGIFNPGGSVSNMCAMNLARYRHCP-DIKDKGLSGLPRLILFTSAECHYSMKKAASFLGI 212
Cdd:COG0076 107 ELEREVVRWLADLLGLPEGaGGVFTSGGTEANLLALLAARDRALArRVRAEGLPGAPRPRIVVSEEAHSSVDKAARLLGL 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799942 213 GTQNVYFVETDGRGKMIPEELEKQIWQGKQEGAVPFLVCATSGTTVLGAFDPLDEIAEVCERHGLWLHVDASWGGSALVS 292
Cdd:COG0076 187 GRDALRKVPVDEDGRMDPDALEAAIDEDRAAGLNPIAVVATAGTTNTGAIDPLAEIADIAREHGLWLHVDAAYGGFALPS 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799942 293 RKHRRLLHGIHRADSVAWNPHKMLMAGIQCSALLVKDKsDLLKKCYSAKATYLFQQDkfyDVSYDTGDKSIQCSRRPDAF 372
Cdd:COG0076 267 PELRHLLDGIERADSITVDPHKWLYVPYGCGAVLVRDP-ELLREAFSFHASYLGPAD---DGVPNLGDYTLELSRRFRAL 342
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799942 373 KFWMTWKAVGTSGLEERVNRAFALSRYLVDEIKKREGFKLLIEPEYTNVCFWYIPPSLREMAEGPEFWRklslvapaikE 452
Cdd:COG0076 343 KLWATLRALGREGYRELIERCIDLARYLAEGIAALPGFELLAPPELNIVCFRYKPAGLDEEDALNYALR----------D 412
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 1958799942 453 KMMKKGSLMLGYQPHRGKVNfFRQVVISPQVSREDMDFLLDEIDSLGRD 501
Cdd:COG0076 413 RLRARGRAFLSPTKLDGRVV-LRLVVLNPRTTEDDVDALLDDLREAAAE 460
|
|
| DOPA_deC_like |
cd06450 |
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
98-498 |
2.32e-122 |
|
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and glutamate decarboxylase (GDC). DDC is active as a dimer and catalyzes the decarboxylation of tyrosine. GDC catalyzes the decarboxylation of glutamate and HDC catalyzes the decarboxylation of histidine.
Pssm-ID: 99743 [Multi-domain] Cd Length: 345 Bit Score: 361.52 E-value: 2.32e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799942 98 FFNQLYAGLDYHSLAARIITEALNPSIYTYEVSPVFLLVEEAVLKKMIECVGW--KEGDGIFNPGGSVSNMCAMNLARYR 175
Cdd:cd06450 1 FLAGFVTTMDPPALLLEMLTSAKNAIDFTWDESPAATEMEAEVVNWLAKLFGLpsEDADGVFTSGGSESNLLALLAARDR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799942 176 HCPDIKDKGLSGLPRLILFTSAECHYSMKKAASFLGIgtqNVYFVETDGRGKMIPEELEKQIWQGKQEGAVPFLVCATSG 255
Cdd:cd06450 81 ARKRLKAGGGRGIDKLVIVCSDQAHVSVEKAAAYLDV---KVRLVPVDEDGRMDPEALEAAIDEDKAEGLNPIMVVATAG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799942 256 TTVLGAFDPLDEIAEVCERHGLWLHVDASWGGSALVSRKHRRLLHGIHRADSVAWNPHKMLMAGIQCSALLVKdksdllk 335
Cdd:cd06450 158 TTDTGAIDPLEEIADLAEKYDLWLHVDAAYGGFLLPFPEPRHLDFGIERVDSISVDPHKYGLVPLGCSAVLVR------- 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799942 336 kcysakatylfqqdkfydvsydtgdksiqcsrrpdAFKFWMTWKAVGTSGLEERVNRAFALSRYLVDEIKKREGFKLLIE 415
Cdd:cd06450 231 -----------------------------------ALKLWATLRRFGRDGYGEHIDRIVDLAKYLAELIRADPGFELLGE 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799942 416 PEYTNVCFWYIPPSlremaegpefwrKLSLVAPAIKEKMMKKGSLMLGYQPHRGKvNFFRQVVISPQVSREDMDFLLDEI 495
Cdd:cd06450 276 PNLSLVCFRLKPSV------------KLDELNYDLSDRLNERGGWHVPATTLGGP-NVLRFVVTNPLTTRDDADALLEDI 342
|
...
gi 1958799942 496 DSL 498
Cdd:cd06450 343 ERA 345
|
|
| Pyridoxal_deC |
pfam00282 |
Pyridoxal-dependent decarboxylase conserved domain; |
58-426 |
2.46e-120 |
|
Pyridoxal-dependent decarboxylase conserved domain;
Pssm-ID: 395219 Cd Length: 373 Bit Score: 357.50 E-value: 2.46e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799942 58 PEQLRQLLDLEMRDTGESQDKLLKLCQDVIRYSVKTNH-PRFFNQLYAGLDYHSLAARIITEALNPSIYTYEVSPVFLLV 136
Cdd:pfam00282 1 PGYLKPLLPLAAPIIPEPELQIDGDIRRNLMPGVTTWHsPHFHAYMPTGNSYPSLLGDMLTDAINCNGFTWESSPACTEL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799942 137 EEAVLKKMIECVGW------KEGDGIFNPGGSVSNMCAMNLARYRHCPDIKDKG-----LSGLPRLILFTSAECHYSMKK 205
Cdd:pfam00282 81 ENVVMNWLGEMLGLpaeflgQEGGGVLQPGSSESNLLALLAARTKWIKRMKAAGkpadsSGILAKLVAYTSDQAHSSIEK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799942 206 AASFLGIGtqnVYFVETDGRGKMIPEELEKQIWQGKQEGAVPFLVCATSGTTVLGAFDPLDEIAEVCERHGLWLHVDASW 285
Cdd:pfam00282 161 AALYGGVK---LREIPSDDNGKMRGMDLEKAIEEDKENGLIPFFVVATLGTTGSGAFDDLQELGDICAKHNLWLHVDAAY 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799942 286 GGSALVSRKHRRLLHGIHRADSVAWNPHKMLMAGIQCSALLVKDKSDlLKKCYSAKATYLFQQDKfydvSYDTGDKSIQC 365
Cdd:pfam00282 238 GGSAFICPEFRHWLFGIERADSITFNPHKWMLVLLDCSAVWVKDKEA-LQQAFQFNPLYLGHTDS----AYDTGHKQIPL 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958799942 366 SRRPDAFKFWMTWKAVGTSGLEERVNRAFALSRYLVDEIKKREGFKLLIEPEYTNVCFWYI 426
Cdd:pfam00282 313 SRRFRILKLWFVIRSLGVEGLQNQIRRHVELAQYLEALIRKDGRFEICAEVGLGLVCFRLK 373
|
|
| PLN02590 |
PLN02590 |
probable tyrosine decarboxylase |
58-427 |
1.36e-41 |
|
probable tyrosine decarboxylase
Pssm-ID: 178200 [Multi-domain] Cd Length: 539 Bit Score: 156.41 E-value: 1.36e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799942 58 PEQLRQLLDLEMRDTGESQDKLLK-LCQDVIRYSVKTNHPRFFNQLYAGLDYHSLAARIITEALNPSIYTYEVSPVFLLV 136
Cdd:PLN02590 92 PGYLRDMLPDSAPERPESLKELLDdVSKKIMPGITHWQSPSYFAYYASSTSVAGFLGEMLNAGLSVVGFTWLTSPAATEL 171
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799942 137 EEAVLKKMIECVGWKE-------GDGIFNPGGSVSNMCAMNLARYRhcpDIKDKGLSGLPRLILFTSAECHYSMKKAASF 209
Cdd:PLN02590 172 EIIVLDWLAKLLQLPDhflstgnGGGVIQGTGCEAVLVVVLAARDR---ILKKVGKTLLPQLVVYGSDQTHSSFRKACLI 248
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799942 210 LGIGTQNVYFVETDGRGK--MIPEELEKQIWQGKQEGAVPFLVCATSGTTVLGAFDPLDEIAEVCERHGLWLHVDASWGG 287
Cdd:PLN02590 249 GGIHEENIRLLKTDSSTNygMPPESLEEAISHDLAKGFIPFFICATVGTTSSAAVDPLVPLGNIAKKYGIWLHVDAAYAG 328
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799942 288 SALVSRKHRRLLHGIHRADSVAWNPHKMLMAGIQCSALLVKDKSDLLKKCYSAKATYLFQQDKfYDVSYDTGDKSIQCSR 367
Cdd:PLN02590 329 NACICPEYRKFIDGIENADSFNMNAHKWLFANQTCSPLWVKDRYSLIDALKTNPEYLEFKVSK-KDTVVNYKDWQISLSR 407
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799942 368 RPDAFKFWMTWKAVGTSGLEERVNRAFALSRYLVDEIKKREGFKLLIEPEYTNVCFWYIP 427
Cdd:PLN02590 408 RFRSLKLWMVLRLYGSENLRNFIRDHVNLAKHFEDYVAQDPSFEVVTTRYFSLVCFRLAP 467
|
|
| PLN02880 |
PLN02880 |
tyrosine decarboxylase |
58-429 |
1.77e-37 |
|
tyrosine decarboxylase
Pssm-ID: 215475 [Multi-domain] Cd Length: 490 Bit Score: 143.90 E-value: 1.77e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799942 58 PEQLRQLLDLEMRDTGESQDKLLKLCQDVIRYSVKT-NHPRFFNQLYAGLDYHSLAARIITEALNPSIYTYEVSPVFLLV 136
Cdd:PLN02880 44 PGYLRELLPDSAPNQPETLDQVLDDVQAKILPGVTHwQSPNYFAYYPSNSSVAGFLGEMLSAGLNIVGFSWITSPAATEL 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799942 137 EEAVLK---KMI----ECVGWKEGDGIFNPGGSVSNMCAMNLARYRhcpDIKDKGLSGLPRLILFTSAECHYSMKKAASF 209
Cdd:PLN02880 124 EMIVLDwlaKLLnlpeQFLSTGNGGGVIQGTASEAVLVVLLAARDR---VLRKVGKNALEKLVVYASDQTHSALQKACQI 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799942 210 LGIGTQNVYFVETDGRGK--MIPEELEKQIWQGKQEGAVPFLVCATSGTTVLGAFDPLDEIAEVCERHGLWLHVDASWGG 287
Cdd:PLN02880 201 AGIHPENCRLLKTDSSTNyaLAPELLSEAISTDLSSGLIPFFLCATVGTTSSTAVDPLLELGKIAKSNGMWFHVDAAYAG 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799942 288 SALVSRKHRRLLHGIHRADSVAWNPHKMLMAGIQCSALLVKDKSDLLKKcYSAKATYLFQQDKFYDVSYDTGDKSIQCSR 367
Cdd:PLN02880 281 SACICPEYRHYIDGVEEADSFNMNAHKWFLTNFDCSLLWVKDRNALIQS-LSTNPEFLKNKASQANSVVDYKDWQIPLGR 359
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958799942 368 RPDAFKFWMTWKAVGTSGLEERVNRAFALSRYLVDEIKKREGFKLLIEPEYTNVCFWYIPPS 429
Cdd:PLN02880 360 RFRSLKLWMVLRLYGVENLQSYIRNHIKLAKEFEQLVAQDSRFEVVTPRIFSLVCFRLVPPK 421
|
|
| PRK02769 |
PRK02769 |
histidine decarboxylase; Provisional |
137-495 |
8.96e-20 |
|
histidine decarboxylase; Provisional
Pssm-ID: 235068 [Multi-domain] Cd Length: 380 Bit Score: 90.87 E-value: 8.96e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799942 137 EEAVLKKMIE--CVGWKEGDGIFNPGGSVSNMCAMNLARYRHcpdikdkglsglPRLILFTSAECHYSMKKAASFLGIGT 214
Cdd:PRK02769 67 ERDVMNFFAElfKIPFNESWGYITNGGTEGNLYGCYLARELF------------PDGTLYYSKDTHYSVSKIARLLRIKS 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799942 215 QnvyFVETDGRGKMIPEELEKQIWQGKQEgavPFLVCATSGTTVLGAFDPLDEIAEVCERHGL---WLHVDASWGGSALV 291
Cdd:PRK02769 135 R---VITSLPNGEIDYDDLISKIKENKNQ---PPIIFANIGTTMTGAIDNIKEIQEILKKIGIddyYIHADAALSGMILP 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799942 292 SRKHRRLLHGIHRADSVAWNPHKMLMAGIQCSALLVKDKSdllkkcysakatylfqQDKFY-DVSY-DTGDKSIQCSRrp 369
Cdd:PRK02769 209 FVNNPPPFSFADGIDSIAISGHKFIGSPMPCGIVLAKKKY----------------VERISvDVDYiGSRDQTISGSR-- 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799942 370 DAFKFWMTWKAV---GTSGLEERVNRAFALSRYLVDEIKKRegfklliepeytNVCFWYIPPSlremaegpefwrkLSLV 446
Cdd:PRK02769 271 NGHTALLLWAAIrslGSKGLRQRVQHCLDMAQYAVDRLQAN------------GIPAWRNPNS-------------ITVV 325
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1958799942 447 APAIKEKMMKKGSL-MLGYQPHrgkvnffrqVVISPQVSREDMDFLLDEI 495
Cdd:PRK02769 326 FPCPSERIWKKWHLaTSGNQAH---------IITMPHHNKQQIDSLIDEL 366
|
|
| AAT_I |
cd01494 |
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ... |
141-328 |
1.61e-09 |
|
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).
Pssm-ID: 99742 [Multi-domain] Cd Length: 170 Bit Score: 57.01 E-value: 1.61e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799942 141 LKKMIECV----GWKEGDGIFNPGGSVSN-MCAMNLARYRhcpdikdkglsglpRLILFtSAECHYSmkKAASFLGIGTQ 215
Cdd:cd01494 2 LEELEEKLarllQPGNDKAVFVPSGTGANeAALLALLGPG--------------DEVIV-DANGHGS--RYWVAAELAGA 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799942 216 NVYFVETDGRGKMI--PEELEKQIWQGKqegavPFLVCATSGTTVLGAFDPLDEIAEVCERHGLWLHVDASWGGSALVSR 293
Cdd:cd01494 65 KPVPVPVDDAGYGGldVAILEELKAKPN-----VALIVITPNTTSGGVLVPLKEIRKIAKEYGILLLVDAASAGGASPAP 139
|
170 180 190
....*....|....*....|....*....|....*
gi 1958799942 294 KHRRllhGIHRADSVAWNPHKmLMAGIQCSALLVK 328
Cdd:cd01494 140 GVLI---PEGGADVVTFSLHK-NLGGEGGGVVIVK 170
|
|
| PLN03032 |
PLN03032 |
serine decarboxylase; Provisional |
188-405 |
2.25e-08 |
|
serine decarboxylase; Provisional
Pssm-ID: 166673 [Multi-domain] Cd Length: 374 Bit Score: 55.99 E-value: 2.25e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799942 188 LPRLILFTSAECHYSMKKAASFLGIGTQNvyfVETDGRGKMIPEELEKQIWQGKQEgavPFLVCATSGTTVLGAFDPLDE 267
Cdd:PLN03032 109 FPDGILYASRESHYSVFKAARMYRMEAVK---VPTLPSGEIDYDDLERALAKNRDK---PAILNVNIGTTVKGAVDDLDR 182
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799942 268 IAEVCERHG-----LWLHVDASWGGSALVSRKHRRLLHGIHRADSVAWNPHKMLMAGIQCSALLVKDKSdllKKCYSAKA 342
Cdd:PLN03032 183 ILRILKELGytedrFYIHCDGALFGLMMPFVSRAPEVTFRKPIGSVSVSGHKFLGCPMPCGVALTRKKH---VKALSQNV 259
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958799942 343 TYLfqqdkfydvsyDTGDKSIQCSRRPDAFKF-WMTWKAVGTSGLEERVNRAFALSRYLVDEIK 405
Cdd:PLN03032 260 EYL-----------NSRDATIMGSRNGHAPLYlWYTLRRKGYRGIKRDVQHCMRNAHYLKDRLT 312
|
|
| Aminotran_5 |
pfam00266 |
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes ... |
156-336 |
4.91e-07 |
|
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes including cysteine desulphurase EC:4.4.1.-.
Pssm-ID: 425567 [Multi-domain] Cd Length: 368 Bit Score: 51.86 E-value: 4.91e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799942 156 IFNPGGSVS-NMCAMNLARYrhcpdIKDKglsglpRLILFTSAEcHYSMKKAASFLGI-GTQNVYFVETDGRGKMIPEEL 233
Cdd:pfam00266 65 IFTSGTTEAiNLVALSLGRS-----LKPG------DEIVITEME-HHANLVPWQELAKrTGARVRVLPLDEDGLLDLDEL 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799942 234 EKQIwqgkQEGAVpfLVCATSGTTVLGAFDPLDEIAEVCERHGLWLHVDASwggSALVSRKH--RRLlhGIhraDSVAWN 311
Cdd:pfam00266 133 EKLI----TPKTK--LVAITHVSNVTGTIQPVPEIGKLAHQYGALVLVDAA---QAIGHRPIdvQKL--GV---DFLAFS 198
|
170 180
....*....|....*....|....*.
gi 1958799942 312 PHKML-MAGIqcSALLVKDksDLLKK 336
Cdd:pfam00266 199 GHKLYgPTGI--GVLYGRR--DLLEK 220
|
|
| GLY1 |
COG2008 |
Threonine aldolase [Amino acid transport and metabolism]; |
222-292 |
1.85e-06 |
|
Threonine aldolase [Amino acid transport and metabolism];
Pssm-ID: 441611 [Multi-domain] Cd Length: 333 Bit Score: 49.68 E-value: 1.85e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958799942 222 TDGRGKMIPEELEKQIWQGKQEGAVPFLVC---ATSGTTVLgAFDPLDEIAEVCERHGLWLHVDASWGGSALVS 292
Cdd:COG2008 105 PGEDGKLTPEDLEAAIRPGDVHFPQPGLVSlenTTEGGTVY-PLEELRAIAAVAREHGLPLHLDGARLFNAAAA 177
|
|
| PLN02263 |
PLN02263 |
serine decarboxylase |
188-495 |
4.25e-06 |
|
serine decarboxylase
Pssm-ID: 177904 [Multi-domain] Cd Length: 470 Bit Score: 49.04 E-value: 4.25e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799942 188 LPRLILFTSAECHYSMKKAASFLGIGTQNvyfVETDGRGKMIPEELEKQIWQGKQEgavPFLVCATSGTTVLGAFDPLDE 267
Cdd:PLN02263 176 FPDGILYASRESHYSVFKAARMYRMECVK---VDTLVSGEIDCADFKAKLLANKDK---PAIINVNIGTTVKGAVDDLDL 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799942 268 IAEVCERHG-----LWLHVDASWGGSALVSRKHRRLLHGIHRADSVAWNPHKMLMAGIQCSALLVKDKSdllKKCYSAKA 342
Cdd:PLN02263 250 VIKTLEECGfsqdrFYIHCDGALFGLMMPFVKRAPKVTFKKPIGSVSVSGHKFVGCPMPCGVQITRMEH---INVLSSNV 326
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799942 343 TYLFQQdkfydvsydtgDKSIQCSRRPDAFKF-WMTWKAVGTSGLEERVNRAFALSRYLVDEIKKrEGFKLLIEPEYTNV 421
Cdd:PLN02263 327 EYLASR-----------DATIMGSRNGHAPIFlWYTLNRKGYRGFQKEVQKCLRNAHYLKDRLRE-AGISAMLNELSSTV 394
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958799942 422 CFwyippslrEMAEGPEFWRKLSLVApaikekmmkkgslmlgyqphRGKVnffRQVVISPQVSREDMDFLLDEI 495
Cdd:PLN02263 395 VF--------ERPKDEEFVRRWQLAC--------------------QGNI---AHVVVMPSVTIEKLDYFLKEL 437
|
|
| CsdA |
COG0520 |
Selenocysteine lyase/Cysteine desulfurase [Amino acid transport and metabolism]; |
186-316 |
4.16e-04 |
|
Selenocysteine lyase/Cysteine desulfurase [Amino acid transport and metabolism];
Pssm-ID: 440286 [Multi-domain] Cd Length: 396 Bit Score: 42.82 E-value: 4.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799942 186 SGLPRL-----ILFTSAEcHYSM----KKAASFLGIgtqNVYFVETDGRGKMIPEELEKQIwqgkqeGAVPFLVCATSGT 256
Cdd:COG0520 95 YGLGRLkpgdeILITEME-HHSNivpwQELAERTGA---EVRVIPLDEDGELDLEALEALL------TPRTKLVAVTHVS 164
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958799942 257 TVLGAFDPLDEIAEVCERHGLWLHVDA--SWGgsalvsrkHRRL-LHGIHrADSVAWNPHKML 316
Cdd:COG0520 165 NVTGTVNPVKEIAALAHAHGALVLVDGaqSVP--------HLPVdVQALG-CDFYAFSGHKLY 218
|
|
| Orn_deC_like |
cd00615 |
Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
265-329 |
1.32e-03 |
|
Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine decarboxylase (LDC). ODC is a dodecamer composed of six homodimers and catalyzes the decarboxylation of tryptophan. ADC catalyzes the decarboxylation of arginine and LDC catalyzes the decarboxylation of lysine. Members of this family are widely found in all three forms of life.
Pssm-ID: 99739 [Multi-domain] Cd Length: 294 Bit Score: 40.69 E-value: 1.32e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958799942 265 LDEIAEVCERHGLWLHVDASWGGSALVSRKHRR--LLHGihrADSVAWNPHKMLMAGIQCSALLVKD 329
Cdd:cd00615 172 LRKIVEEAHHRGLPVLVDEAHGAHFRFHPILPSsaAMAG---ADIVVQSTHKTLPALTQGSMIHVKG 235
|
|
| TA_like |
cd06502 |
Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP) ... |
224-292 |
2.74e-03 |
|
Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a secondary glycine biosynthetic pathway.
Pssm-ID: 99748 [Multi-domain] Cd Length: 338 Bit Score: 40.01 E-value: 2.74e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958799942 224 GRGKMIPEELEKQIWQGKQE-GAVPFLVCATSgTTVLGAFDPLDE---IAEVCERHGLWLHVDASWGGSALVS 292
Cdd:cd06502 104 ENGKLTPEDLEAAIRPRDDIhFPPPSLVSLEN-TTEGGTVYPLDElkaISALAKENGLPLHLDGARLANAAAA 175
|
|
| NifS |
COG1104 |
Cysteine desulfurase/Cysteine sulfinate desulfinase IscS or related enzyme, NifS family [Amino ... |
156-283 |
6.96e-03 |
|
Cysteine desulfurase/Cysteine sulfinate desulfinase IscS or related enzyme, NifS family [Amino acid transport and metabolism];
Pssm-ID: 440721 [Multi-domain] Cd Length: 381 Bit Score: 38.88 E-value: 6.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799942 156 IFNPGGSVSNmcamNLAryrhcpdIK-------DKGlsglpRLILFTSAEcHYSMKKAASFL---GIgtqNVYFVETDGR 225
Cdd:COG1104 66 IFTSGGTEAN----NLA-------IKgaarayrKKG-----KHIITSAIE-HPAVLETARFLekeGF---EVTYLPVDED 125
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1958799942 226 GKMIPEELEKQIWQGkqegavPFLVCATSGTTVLGAFDPLDEIAEVCERHGLWLHVDA 283
Cdd:COG1104 126 GRVDLEALEAALRPD------TALVSVMHANNETGTIQPIAEIAEIAKEHGVLFHTDA 177
|
|
| |
