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Conserved domains on  [gi|1958666871|ref|XP_038944732|]
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PR domain zinc finger protein 15 isoform X6 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PR-SET_PRDM15 cd19199
PR-SET domain found in PR domain zinc finger protein 15 (PRDM15) and similar proteins; PRDM15 ...
 41-166 1.67e-79

PR-SET domain found in PR domain zinc finger protein 15 (PRDM15) and similar proteins; PRDM15 (also termed PR domain-containing protein 15, or zinc finger protein 298 (ZNF298)) may be involved in transcriptional regulation. It plays an essential role as a chromatin factor that modulates the transcription of upstream regulators of WNT and MAPK-ERK signaling to safeguard naive pluripotency.


:

Pssm-ID: 380976  Cd Length: 126  Bit Score: 255.42  E-value: 1.67e-79
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958666871   41 SRARSSLPSNLEIRRLDDGAEGVFAVTQLVKRTQFGPFESRRVAKWEKESAFPLKVFQKDGHPVCFDTSNEDDCNWMMLV 120
Cdd:cd19199      1 SRARSSLPDNLEIRQLEDGSEGVFALVPLVKRTQFGPFEAKRVARLDGFAVFPLKVFEKDGSVVYLDTSNEDDCNWMMFV 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1958666871  121 RPALEPGHQNLTAYQHGSDVYFTTSKDIPAGTELRVWYAAFYAKKM 166
Cdd:cd19199     81 RPATDVEHQNLTAYQQGEDIYFTTSRDIQPGAELRVWYAAFYAKKM 126
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
631-800 3.48e-07

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.32  E-value: 3.48e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958666871  631 CSICHRRFALKATYHAHMVIHRENLPdPNVQKYIHPCEICGRIFNSIGNLERHK--LIHTG--VKSHAC--EQCGKSFAR 704
Cdd:COG5048    257 ASESPRSSLPTASSQSSSPNESDSSS-EKGFSLPIKSKQCNISFSRSSPLTRHLrsVNHSGesLKPFSCpySLCGKLFSR 335

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958666871  705 KDMLKEHMRVHDNIREYLC--AECGKGMKTK-----HALRHHMKLHKGIKEYEC--KECHRKFAQKVNMLKHYKRHT--G 773
Cdd:COG5048    336 NDALKRHILLHTSISPAKEklLNSSSKFSPLlnnepPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLsfR 415

                          170       180
                   ....*....|....*....|....*..
gi 1958666871  774 IKDFMCELCGKTFSERNTMETHKLIHT 800
Cdd:COG5048    416 PYNCKNPPCSKSFNRHYNLIPHKKIHT 442
zf_PR_Knuckle super family cl39781
PR zinc knuckle motif; This is a zinc knuckle motif found in PRDM4 (Schwann cell factor 1, ...
 12-37 1.33e-03

PR zinc knuckle motif; This is a zinc knuckle motif found in PRDM4 (Schwann cell factor 1, SC-1), a member of the PR protein family. PRDM4 is a transcriptional regulator that has been implied in transduction of nerve growth factor signals via the p75 neurotrophin receptor and in cell growth arrest. The short motif is also present in several other PR proteins including human PRDM6 (PRISM), PRDM7, PRDM9 (meisetz), PRDM10 (tristanin), PRDM11, and PRDM15. The conservation of cysteine and histidine residues suggested that this 20 amino acid motif binds zinc, hence the name 'PR zinc knuckle' to distinguish it from the longer (30 amino acid) C2H2-like zinc fingers that are located C-terminally of the PR domain. The PR zinc knuckle fold is similar to that of Gag-knuckles (a beta-hairpin providing two zinc ligands followed by a short helix or a loop providing the other two zinc ligands) and zinc ribbons (two beta-hairpins, each providing two zinc ligands).


The actual alignment was detected with superfamily member pfam18445:

Pssm-ID: 375871  Cd Length: 38  Bit Score: 37.27  E-value: 1.33e-03
                           10        20
                   ....*....|....*....|....*.
gi 1958666871   12 IWCEDCSQYHDSECPELGPVVMVKDS 37
Cdd:pfam18445   11 IWCTLCERSYPSDCPEHGPVTFIPDT 36
 
Name Accession Description Interval E-value
PR-SET_PRDM15 cd19199
PR-SET domain found in PR domain zinc finger protein 15 (PRDM15) and similar proteins; PRDM15 ...
 41-166 1.67e-79

PR-SET domain found in PR domain zinc finger protein 15 (PRDM15) and similar proteins; PRDM15 (also termed PR domain-containing protein 15, or zinc finger protein 298 (ZNF298)) may be involved in transcriptional regulation. It plays an essential role as a chromatin factor that modulates the transcription of upstream regulators of WNT and MAPK-ERK signaling to safeguard naive pluripotency.


Pssm-ID: 380976  Cd Length: 126  Bit Score: 255.42  E-value: 1.67e-79
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958666871   41 SRARSSLPSNLEIRRLDDGAEGVFAVTQLVKRTQFGPFESRRVAKWEKESAFPLKVFQKDGHPVCFDTSNEDDCNWMMLV 120
Cdd:cd19199      1 SRARSSLPDNLEIRQLEDGSEGVFALVPLVKRTQFGPFEAKRVARLDGFAVFPLKVFEKDGSVVYLDTSNEDDCNWMMFV 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1958666871  121 RPALEPGHQNLTAYQHGSDVYFTTSKDIPAGTELRVWYAAFYAKKM 166
Cdd:cd19199     81 RPATDVEHQNLTAYQQGEDIYFTTSRDIQPGAELRVWYAAFYAKKM 126
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
631-800 3.48e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.32  E-value: 3.48e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958666871  631 CSICHRRFALKATYHAHMVIHRENLPdPNVQKYIHPCEICGRIFNSIGNLERHK--LIHTG--VKSHAC--EQCGKSFAR 704
Cdd:COG5048    257 ASESPRSSLPTASSQSSSPNESDSSS-EKGFSLPIKSKQCNISFSRSSPLTRHLrsVNHSGesLKPFSCpySLCGKLFSR 335

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958666871  705 KDMLKEHMRVHDNIREYLC--AECGKGMKTK-----HALRHHMKLHKGIKEYEC--KECHRKFAQKVNMLKHYKRHT--G 773
Cdd:COG5048    336 NDALKRHILLHTSISPAKEklLNSSSKFSPLlnnepPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLsfR 415

                          170       180
                   ....*....|....*....|....*..
gi 1958666871  774 IKDFMCELCGKTFSERNTMETHKLIHT 800
Cdd:COG5048    416 PYNCKNPPCSKSFNRHYNLIPHKKIHT 442
zf-H2C2_2 pfam13465
Zinc-finger double domain;
679-704 2.12e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 2.12e-04
                           10        20
                   ....*....|....*....|....*.
gi 1958666871  679 NLERHKLIHTGVKSHACEQCGKSFAR 704
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 50-165 1.11e-03

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 40.01  E-value: 1.11e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958666871    50 NLEIRRLDDGAEGVFAVTQLVKRTQFGPF---------ESRRVAKWEKESAFPLKVFQKDGHPVCfDTSNEDdcNWMMLV 120
Cdd:smart00317    2 KLEVFKSPGKGWGVRATEDIPKGEFIGEYvgeiitseeAEERPKAYDTDGAKAFYLFDIDSDLCI-DARRKG--NLARFI 78

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*.
gi 1958666871   121 RPALEPGHQNLTAYQHG-SDVYFTTSKDIPAGTELRVWYAAFYAKK 165
Cdd:smart00317   79 NHSCEPNCELLFVEVNGdDRIVIFALRDIKPGEELTIDYGSDYANE 124
zf_PR_Knuckle pfam18445
PR zinc knuckle motif; This is a zinc knuckle motif found in PRDM4 (Schwann cell factor 1, ...
 12-37 1.33e-03

PR zinc knuckle motif; This is a zinc knuckle motif found in PRDM4 (Schwann cell factor 1, SC-1), a member of the PR protein family. PRDM4 is a transcriptional regulator that has been implied in transduction of nerve growth factor signals via the p75 neurotrophin receptor and in cell growth arrest. The short motif is also present in several other PR proteins including human PRDM6 (PRISM), PRDM7, PRDM9 (meisetz), PRDM10 (tristanin), PRDM11, and PRDM15. The conservation of cysteine and histidine residues suggested that this 20 amino acid motif binds zinc, hence the name 'PR zinc knuckle' to distinguish it from the longer (30 amino acid) C2H2-like zinc fingers that are located C-terminally of the PR domain. The PR zinc knuckle fold is similar to that of Gag-knuckles (a beta-hairpin providing two zinc ligands followed by a short helix or a loop providing the other two zinc ligands) and zinc ribbons (two beta-hairpins, each providing two zinc ligands).


Pssm-ID: 375871  Cd Length: 38  Bit Score: 37.27  E-value: 1.33e-03
                           10        20
                   ....*....|....*....|....*.
gi 1958666871   12 IWCEDCSQYHDSECPELGPVVMVKDS 37
Cdd:pfam18445   11 IWCTLCERSYPSDCPEHGPVTFIPDT 36
 
Name Accession Description Interval E-value
PR-SET_PRDM15 cd19199
PR-SET domain found in PR domain zinc finger protein 15 (PRDM15) and similar proteins; PRDM15 ...
 41-166 1.67e-79

PR-SET domain found in PR domain zinc finger protein 15 (PRDM15) and similar proteins; PRDM15 (also termed PR domain-containing protein 15, or zinc finger protein 298 (ZNF298)) may be involved in transcriptional regulation. It plays an essential role as a chromatin factor that modulates the transcription of upstream regulators of WNT and MAPK-ERK signaling to safeguard naive pluripotency.


Pssm-ID: 380976  Cd Length: 126  Bit Score: 255.42  E-value: 1.67e-79
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958666871   41 SRARSSLPSNLEIRRLDDGAEGVFAVTQLVKRTQFGPFESRRVAKWEKESAFPLKVFQKDGHPVCFDTSNEDDCNWMMLV 120
Cdd:cd19199      1 SRARSSLPDNLEIRQLEDGSEGVFALVPLVKRTQFGPFEAKRVARLDGFAVFPLKVFEKDGSVVYLDTSNEDDCNWMMFV 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1958666871  121 RPALEPGHQNLTAYQHGSDVYFTTSKDIPAGTELRVWYAAFYAKKM 166
Cdd:cd19199     81 RPATDVEHQNLTAYQQGEDIYFTTSRDIQPGAELRVWYAAFYAKKM 126
PR-SET_PRDM10 cd19194
PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins; PRDM10 ...
 42-166 5.20e-47

PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins; PRDM10 (also termed PR domain-containing protein 10, or tristanin) may be involved in transcriptional regulation.


Pssm-ID: 380971  Cd Length: 128  Bit Score: 164.06  E-value: 5.20e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958666871   42 RARSSLPSNLEIRRLDDGAEGVFAVTQLVKRTQFGPFESRRVAKWEK--ESAFPLKVFQKDGHPVCFDTSNEDDCNWMML 119
Cdd:cd19194      1 RARASLPLILQIFRFGETLGGVFAKRRIPKRTQFGPLEGPLVKKSELkdNKIHPLELEEDDGEDLYFDLSDENKCNWMMF 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1958666871  120 VRPALEPGHQNLTAYQHGSDVYFTTSKDIPAGTELRVWYAAFYAKKM 166
Cdd:cd19194     81 VRPAQNHLEQNLVAYQYGQEIYFTTIKNIEPKQELKVWYAASYAEFL 127
PR-SET_PRDM4 cd19189
PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 ...
 42-166 5.43e-32

PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 (also termed PR domain-containing protein 4, or PFM1) may function as a transcription factor involved in cell differentiation.


Pssm-ID: 380966  Cd Length: 133  Bit Score: 121.42  E-value: 5.43e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958666871   42 RARSSLPSNLEIRRLDDGAE-GVFAVTQLVKRTQFGPF-----ESRRVAKWEKESAFPL-KVFQKDGHPVCFDTSNEDDC 114
Cdd:cd19189      1 RARLSLPRQLYLRQSETGAEvGVWTKETIPVRTCFGPLigqqsHSAEVADWTDKAAPHIwKIYHNDVLEFCIITTDENEC 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1958666871  115 NWMMLVRPALEPGHQNLTAYQHGSDVYFTTSKDIPAGTELRVWYAAFYAKKM 166
Cdd:cd19189     81 NWMMFVRKARTREEQNLVAYPHDGKIYFCTSRDIPPDQELLFYYSRDYARQL 132
PR-SET_PRDM-like cd10534
PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family ...
 47-158 6.16e-27

PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family of proteins is defined based on the conserved N-terminal PR domain, which is closely related to the Su(var)3-9, enhancer of zeste, and trithorax (SET) domains of histone methyltransferases, and is specifically called PR-SET domain. The family consists of 17 members in primates. PRDMs play diverse roles in cell-cycle regulation, differentiation, and meiotic recombination. The family also contains zinc finger protein ZFPM1 and ZFPM2. ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380932  Cd Length: 83  Bit Score: 104.97  E-value: 6.16e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958666871   47 LPSNLEIRRLDD--GAEGVFAVTQLVKRTQFGPFESRRvakwekesafplkvfqkdghpvcfdtsneddcNWMMLVRPAL 124
Cdd:cd10534      1 LPAGLELVLSSIpeGGLGVFARRTIPAGTRFGPLEGVV--------------------------------NWMRFVRPAR 48

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1958666871  125 EPGHQNLTAYQHGSDVYFTTSKDIPAGTELRVWY 158
Cdd:cd10534     49 NEEEQNLVAYQHGGQIYFRTTRDIPPGEELLVWY 82
PR-SET_PRDM1 cd19187
PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 ...
 46-165 3.23e-21

PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 (also termed BLIMP-1, beta-interferon gene positive regulatory domain I-binding factor, PR domain-containing protein 1, positive regulatory domain I-binding factor 1, PRDI-BF1, or PRDI-binding factor 1) acts as a transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs.


Pssm-ID: 380964 [Multi-domain]  Cd Length: 128  Bit Score: 90.46  E-value: 3.23e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958666871   46 SLPSNLEIRRLDDGAE--GVFAVTQLVKRTQFGPFESRRVAKWEKESAFPLKVF---QKDGHPVCF-DTSNEDDCNWMML 119
Cdd:cd19187      2 SLPRNLTLKYSSVGREvlGVWSSDYIPRGTRFGPLVGEIYTNDPVPKGANRKYFwriYSNGEFYHYiDGFDPSKSNWMRY 81

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1958666871  120 VRPALEPGHQNLTAYQHGSDVYFTTSKDIPAGTELRVWYAAFYAKK 165
Cdd:cd19187     82 VNPAHSLQEQNLVACQIGMNIYFYTVKPIPPNQELLVWYCREFARR 127
PR-SET_PRDM7_9 cd19193
PR-SET domain found in PR domain zinc finger protein 7 (PRDM7) and 9 (PRDM9) and similar ...
 44-164 4.16e-20

PR-SET domain found in PR domain zinc finger protein 7 (PRDM7) and 9 (PRDM9) and similar proteins; PRDM7 (also termed PR domain-containing protein 7) is a primate-specific histone methyltransferase that is the result of a recent gene duplication of PRDM9. It selectively catalyzes the trimethylation of H3 lysine 4 (H3K4me3). PRDM9 (also termed PR domain-containing protein 9) is a histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 (H3K4me3) during meiotic prophase and is essential for proper meiotic progression. It also efficiently mono-, di-, and trimethylates H3K36. Aberrant PRDM9 expression is assciated with with genome instability in cancer.


Pssm-ID: 380970 [Multi-domain]  Cd Length: 129  Bit Score: 87.29  E-value: 4.16e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958666871   44 RSSLPSNLEIRR--LDDGAEGVFAVTQLVKRTQFGPFESRRVAKWE-KESAFPLKVFQKDGHPVCFDTSNEDDCNWMMLV 120
Cdd:cd19193      1 RLTLPPGLSIKRssIPGAGLGVWAEAPIPKGMVFGPYEGEIVEDEEaADSGYSWQIYKGGKLSHYIDAKDESKSNWMRYV 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1958666871  121 RPALEPGHQNLTAYQHGSDVYFTTSKDIPAGTELRVWYAAFYAK 164
Cdd:cd19193     81 NCARNEEEQNLVAFQYRGKIYYRTCKDIAPGTELLVWYGDEYAK 124
PR-SET_PRDM12 cd19196
PR-SET domain found in PR domain zinc finger protein 12 (PRDM12) and similar proteins; PRDM12 ...
 43-169 1.77e-17

PR-SET domain found in PR domain zinc finger protein 12 (PRDM12) and similar proteins; PRDM12 (also termed PR domain-containing protein 12) acts as a transcription factor that is involved in the positive regulation of histone H3-K9 dimethylation.


Pssm-ID: 380973 [Multi-domain]  Cd Length: 130  Bit Score: 79.71  E-value: 1.77e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958666871   43 ARSSLPsnleirrlddGAE-GVFAVTQLVKRTQFGPFESRRVAK----WEKESAFPLKVFQKDGHPVCF-DTSNEDDCNW 116
Cdd:cd19196      8 AQSSIP----------GAGlGVFSKTWIKEGTEMGPYTGRIVSPedvdPCKNNNLMWEVFNEDGTVSHFiDASQENHRSW 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1958666871  117 MMLVRPALEPGHQNLTAYQHGSDVYFTTSKDIPAGTELRVWYAAFYAKKMDKP 169
Cdd:cd19196     78 MTFVNCARNEQEQNLEVVQIGESIYYRAIKDIPPDQELLVWYGNSYNTFLGIP 130
PR-SET_ZFPM cd19201
PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also ...
 45-158 2.46e-17

PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380978  Cd Length: 122  Bit Score: 78.93  E-value: 2.46e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958666871   45 SSLPSNLEIRRLDDGAE---GVFAVTQLVKRTQFGPFEsrrvAKWEKESAFP---LKVFQKDG-HPVCFDTSNEDDCNWM 117
Cdd:cd19201      1 LSLPGELELRKPSQDAGrsgGVWAKQPLPEGTRFGPYP----GKLVKEPLDPsyeWKVEAQGSkGGEGLLLLTEDSGTWL 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1958666871  118 MLVRPALEPGHQNLTAYQHGSDVYFTTSKDIPAGTELRVWY 158
Cdd:cd19201     77 KLVRSADDEDEANLILYFKGGQIWCEVTKDIPPGEELILVL 117
PR-SET_PRDM14 cd19198
PR-SET domain found in PR domain zinc finger protein 14 (PRDM14) and similar proteins; PRDM14 ...
 62-170 1.68e-16

PR-SET domain found in PR domain zinc finger protein 14 (PRDM14) and similar proteins; PRDM14 (also termed PR domain-containing protein 14) acts as a transcription factor that has both positive and negative roles on transcription. It acts on regulating epigenetic modifications in the cells, playing a key role in the regulation of cell pluripotency, epigenetic reprogramming, differentiation and development. Aberrant PRDM14 expression is associated with tumorigenesis, cell migration and cell chemotherapeutic drugs resistance.


Pssm-ID: 380975  Cd Length: 133  Bit Score: 77.05  E-value: 1.68e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958666871   62 GVFAVTQLVKRTQFGPFESRRV----AKWEKESAFPLKVFQkDGHPVCFDTSNEDDCNWMMLVRPALEPGHQNLTAYQHG 137
Cdd:cd19198     21 GVFCKKTIPKGTRFGPFRGRVVntseIKTYDDNSFMWEIFE-DGKLSHFIDGRGSTGNWMSYVNCARYAEEQNLIAIQCQ 99

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1958666871  138 SDVYFTTSKDIPAGTELRVWYAAFYAKKMDKPM 170
Cdd:cd19198    100 GQIFYESCKEILQGQELLVWYGDCYLQFMGIPV 132
PR-SET_PRDM11 cd19195
PR-SET domain found in PR domain zinc finger protein 11 (PRDM11) and similar proteins; PRDM11 ...
 46-166 1.12e-15

PR-SET domain found in PR domain zinc finger protein 11 (PRDM11) and similar proteins; PRDM11 (also termed PR domain-containing protein 11) may be involved in transcription regulation.


Pssm-ID: 380972  Cd Length: 127  Bit Score: 74.51  E-value: 1.12e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958666871   46 SLPSNLEIRRLDDGAEGVFAVTQLVKRTQ-FGPFESRRVAKWEKESAFPLKVFQKDGHPVCFDTSNEDDCNWMMLVRPAL 124
Cdd:cd19195      4 TAPQGIEVVKDTSGESDVRCVDEVIPKGHiFGPYEGQICTQDKSSGFFSWLIVDKNNRYKSIDGSDETKANWMRYVVISR 83

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1958666871  125 EPGHQNLTAYQHGSDVYFTTSKDIPAGTELRVWYAAFYAKKM 166
Cdd:cd19195     84 EEREQNLLAFQHSEQIYFRACRDIRPGEKLRVWYSEDYMKRL 125
PR-SET_PRDM2 cd19188
PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 ...
 47-158 7.81e-12

PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 (also termed GATA-3-binding protein G3B, lysine N-methyltransferase 8, MTB-or MTE-binding protein, PR domain-containing protein 2, retinoblastoma protein-interacting zinc finger protein, or zinc finger protein RIZ) is S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. It may function as a DNA-binding transcription factor.


Pssm-ID: 380965  Cd Length: 123  Bit Score: 63.61  E-value: 7.81e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958666871   47 LPSNLEIRR--LDDGAEGVFAVTQLVKRTQFGPFESRRVAKWE-KESAFPLKVFQKDGHPVCFDTSNEDDCNWMMLVRPA 123
Cdd:cd19188      4 LPEELELKPsaVDKTRIGVWAKKSIPKGRKFGPFVGEKKKRSQvKNNVYMWEIYGPKRGWMCVDASDPTKGNWLRYVNWA 83

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1958666871  124 LEPGHQNLTAYQHGSDVYFTTSKDIPAGTELRVWY 158
Cdd:cd19188     84 RSGEEQNLFPLQINRAIYYKTLKPIAPGEELLCWY 118
PR-SET_PRDM6 cd19191
PR-SET domain found in PR domain zinc finger protein 6 (PRDM6) and similar proteins; PRDM6 ...
 62-158 4.86e-11

PR-SET domain found in PR domain zinc finger protein 6 (PRDM6) and similar proteins; PRDM6 (also termed PR domain-containing protein 6) is a putative histone-lysine N-methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. It may specifically methylate 'Lys-20' of histone H4 when associated with other proteins and in vitro.


Pssm-ID: 380968  Cd Length: 128  Bit Score: 61.34  E-value: 4.86e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958666871   62 GVFAVTQLVKRTQFGPFESRRV-----AKWEKESAFPLKVFQKDGHPVCF-DTSNEDDCNWMMLVRPALEPGHQNLTAYQ 135
Cdd:cd19191     18 GICAAQRIPQGTWIGPFEGVLVspekqIGAVRNTQHLWEIYDQEGTLQHFiDGGDPSKSSWMRYIRCARHCGEQNLTVVQ 97

                           90       100
                   ....*....|....*....|...
gi 1958666871  136 HGSDVYFTTSKDIPAGTELRVWY 158
Cdd:cd19191     98 YRGCIFYRACRDIPRGTELLVWY 120
PR-SET_PRDM8 cd19192
PR-SET domain found in PR domain zinc finger protein 8 (PRDM8) and similar proteins; PRDM8 ...
 56-158 4.22e-08

PR-SET domain found in PR domain zinc finger protein 8 (PRDM8) and similar proteins; PRDM8 (also termed PR domain-containing protein 8) may function as histone methyltransferase, preferentially acting on 'Lys-9' of histone H3.


Pssm-ID: 380969  Cd Length: 131  Bit Score: 52.82  E-value: 4.22e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958666871   56 LDDGAEGVFAVTQLVKRTQFGP----FESRRVAKWEKESAFPLK-VFQKDGHPVCFDTSNEDDCNWMMLVRPALEPGHQN 130
Cdd:cd19192     15 LTDIFTSVVTTTDIPAGTIFGPcvlsFTLGYDIADIALKTTDKRvVPYIFRVDTGACNGSSEPSDWLRLVQPARDRHEQN 94

                           90       100
                   ....*....|....*....|....*....
gi 1958666871  131 LTAYQHG-SDVYFTTSKDIPAGTELRVWY 158
Cdd:cd19192     95 LEAFRKNeGQVYFRTLRRIRKGEELLVWY 123
PR-SET_PRDM16_PRDM3 cd19200
PR-SET domain found in PR domain zinc finger protein 16 (PRDM16), MDS1 and EVI1 complex locus ...
 46-163 4.64e-08

PR-SET domain found in PR domain zinc finger protein 16 (PRDM16), MDS1 and EVI1 complex locus protein and similar proteins; PRDM16 (also termed PR domain-containing protein 16, transcription factor MEL1, or MDS1/EVI1-like gene 1) functions as a transcriptional regulator. PRDM16 is preferentially expressed by hematopoietic and neuronal stem cells. It is closely related to paralog of PRDM3 (also termed MDS1 and EVI1 complex locus protein, ecotropic virus integration site 1 protein, EVI-1, myelodysplasia syndrome 1 protein, myelodysplasia syndrome-associated protein 1, or MECOM) which is a nuclear transcription factor essential for the proliferation/maintenance of hematopoietic stem cells (HSCs). PRDM3 and PRDM16 are both directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380977  Cd Length: 135  Bit Score: 53.14  E-value: 4.64e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958666871   46 SLPSNLEIR--RLDDGAEGVFAVTQLVKRTQFGPFES-RRVAKweKESAFPLKVFQKDGH-PVCFDTSNEDDCNWMMLVR 121
Cdd:cd19200      9 PIPPDFELResAAVGAGLGVWTKVRIEVGEKFGPFVGvQRSSV--KDPTYAWEIVDEFGKvKFWIDASEPGTGNWMKYIR 86

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1958666871  122 PALEPGHQNLTAYQHGSDVYFTTSKDIPAGTELRVWY-AAFYA 163
Cdd:cd19200     87 SAPSCEQQNLMACQIDEQIYYKVVRDIQPGEELLLYMkAAVYP 129
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
631-800 3.48e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.32  E-value: 3.48e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958666871  631 CSICHRRFALKATYHAHMVIHRENLPdPNVQKYIHPCEICGRIFNSIGNLERHK--LIHTG--VKSHAC--EQCGKSFAR 704
Cdd:COG5048    257 ASESPRSSLPTASSQSSSPNESDSSS-EKGFSLPIKSKQCNISFSRSSPLTRHLrsVNHSGesLKPFSCpySLCGKLFSR 335

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958666871  705 KDMLKEHMRVHDNIREYLC--AECGKGMKTK-----HALRHHMKLHKGIKEYEC--KECHRKFAQKVNMLKHYKRHT--G 773
Cdd:COG5048    336 NDALKRHILLHTSISPAKEklLNSSSKFSPLlnnepPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLsfR 415

                          170       180
                   ....*....|....*....|....*..
gi 1958666871  774 IKDFMCELCGKTFSERNTMETHKLIHT 800
Cdd:COG5048    416 PYNCKNPPCSKSFNRHYNLIPHKKIHT 442
PR-SET_PRDM5 cd19190
PR-SET domain found in PR domain zinc finger protein 5 (PRDM5) and similar proteins; PRDM5 ...
 51-158 2.85e-06

PR-SET domain found in PR domain zinc finger protein 5 (PRDM5) and similar proteins; PRDM5 (also termed PR domain-containing protein 5) is a sequence-specific DNA-binding transcription factor that represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1.


Pssm-ID: 380967  Cd Length: 127  Bit Score: 47.67  E-value: 2.85e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958666871   51 LEIRRLDDGAeGVFAVTQLVKRTQFGPFE-SRRVAKWEKESAFPLKVFQKDGHP----VCFDTSNEDDCNWMMLVRPALE 125
Cdd:cd19190     11 LKSSKVQDGM-GLYTARRVKKGEKFGPFAgEKRMPNELDESMDPRLMWEVRGSKgevlYILDASNPRHSNWLRFVHEAPS 89

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1958666871  126 PGHQNLTAYQHGSDVYFTTSKDIPAGTELRVWY 158
Cdd:cd19190     90 QEQKNLAAIQEGENIFYLAVDDIETDTELLIGY 122
PR-SET_PRDM13 cd19197
PR-SET domain found in PR domain zinc finger protein 13 (PRDM13) and similar proteins; PRDM13 ...
 107-159 1.26e-05

PR-SET domain found in PR domain zinc finger protein 13 (PRDM13) and similar proteins; PRDM13 (also termed PR domain-containing protein 13) may be involved in transcriptional regulation. It mediates the balance of inhibitory and excitatory neurons in somatosensory circuits.


Pssm-ID: 380974  Cd Length: 103  Bit Score: 45.20  E-value: 1.26e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958666871  107 DTSNEDDCNWMMLVRPALEPGHQNLTAYQ--HGSDVYFTTSKDIPAGTELRVWYA 159
Cdd:cd19197     42 DESGSPATEWIGLVRAARNNQEQNLEAIAdlPGGQIFYRALRDIQPGEELTVWYS 96
PR-SET_PRDM16 cd19213
PR-SET domain found in PR domain zinc finger protein 16 (PRDM16) and similar proteins; PRDM16, ...
 47-157 1.40e-05

PR-SET domain found in PR domain zinc finger protein 16 (PRDM16) and similar proteins; PRDM16, also termed PR domain-containing protein 16, or transcription factor MEL1, or MDS1/EVI1-like gene 1, functions as a transcriptional regulator. PRDM16 is preferentially expressed by hematopoietic and neuronal stem cells and is closely related to paralog of PRDM3, both of which are directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380990  Cd Length: 162  Bit Score: 46.41  E-value: 1.40e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958666871   47 LPSNLEIRR--LDDGAEGVFAVTQLVKRTQFGPFES--RRVAK-----WEK-----ESAFPLKVFQKDGHPV-----CFD 107
Cdd:cd19213     20 IPSDFELREssIPGAGLGVWAKRKIEAGERFGPYTGvqRSTLKdtnfgWEQilndvEVSSQEGCITKIVDDLgnekfCVD 99

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1958666871  108 TSNEDDCNWMMLVRPALEPGHQNLTAYQHGSDVYFTTSKDIPAGTELRVW 157
Cdd:cd19213    100 AGQAGAGSWLKYIRVACSCDEQNLTACQINEQIYYKVIKDIEPGEELLVY 149
zf-H2C2_2 pfam13465
Zinc-finger double domain;
679-704 2.12e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 2.12e-04
                           10        20
                   ....*....|....*....|....*.
gi 1958666871  679 NLERHKLIHTGVKSHACEQCGKSFAR 704
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 50-165 1.11e-03

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 40.01  E-value: 1.11e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958666871    50 NLEIRRLDDGAEGVFAVTQLVKRTQFGPF---------ESRRVAKWEKESAFPLKVFQKDGHPVCfDTSNEDdcNWMMLV 120
Cdd:smart00317    2 KLEVFKSPGKGWGVRATEDIPKGEFIGEYvgeiitseeAEERPKAYDTDGAKAFYLFDIDSDLCI-DARRKG--NLARFI 78

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*.
gi 1958666871   121 RPALEPGHQNLTAYQHG-SDVYFTTSKDIPAGTELRVWYAAFYAKK 165
Cdd:smart00317   79 NHSCEPNCELLFVEVNGdDRIVIFALRDIKPGEELTIDYGSDYANE 124
zf_PR_Knuckle pfam18445
PR zinc knuckle motif; This is a zinc knuckle motif found in PRDM4 (Schwann cell factor 1, ...
 12-37 1.33e-03

PR zinc knuckle motif; This is a zinc knuckle motif found in PRDM4 (Schwann cell factor 1, SC-1), a member of the PR protein family. PRDM4 is a transcriptional regulator that has been implied in transduction of nerve growth factor signals via the p75 neurotrophin receptor and in cell growth arrest. The short motif is also present in several other PR proteins including human PRDM6 (PRISM), PRDM7, PRDM9 (meisetz), PRDM10 (tristanin), PRDM11, and PRDM15. The conservation of cysteine and histidine residues suggested that this 20 amino acid motif binds zinc, hence the name 'PR zinc knuckle' to distinguish it from the longer (30 amino acid) C2H2-like zinc fingers that are located C-terminally of the PR domain. The PR zinc knuckle fold is similar to that of Gag-knuckles (a beta-hairpin providing two zinc ligands followed by a short helix or a loop providing the other two zinc ligands) and zinc ribbons (two beta-hairpins, each providing two zinc ligands).


Pssm-ID: 375871  Cd Length: 38  Bit Score: 37.27  E-value: 1.33e-03
                           10        20
                   ....*....|....*....|....*.
gi 1958666871   12 IWCEDCSQYHDSECPELGPVVMVKDS 37
Cdd:pfam18445   11 IWCTLCERSYPSDCPEHGPVTFIPDT 36
PR-SET_PRDM3 cd19214
PR-SET domain found in MDS1 and EVI1 complex locus protein and similar proteins; PRDM3 (also ...
 47-154 1.80e-03

PR-SET domain found in MDS1 and EVI1 complex locus protein and similar proteins; PRDM3 (also termed MDS1 and EVI1 complex locus protein, ecotropic virus integration site 1 protein, EVI-1, myelodysplasia syndrome 1 protein, myelodysplasia syndrome-associated protein 1, or MECOM) is a nuclear transcription factor, which is essential for the proliferation/maintenance of hematopoietic stem cells (HSCs). It is closely related to paralog PRDM16, both o fwhich are directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380991  Cd Length: 158  Bit Score: 40.31  E-value: 1.80e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958666871   47 LPSNLEIRR--LDDGAEGVFAVTQLVKRTQFGPFESRRVAKWeKESAFPLKVFQKDGH-PVCFDTSNEDDCNWMMLVRPA 123
Cdd:cd19214     30 IPSEFELREsnIPGTGLGIWTKRKIEVGEKFGPYVGEQRSNL-KDPSYGWEVLDEFGNvKFCIDASQPDVGSWLKYIRFA 108

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1958666871  124 LEPGHQNLTAYQHGSDVYFTTSKDIPAGTEL 154
Cdd:cd19214    109 GCYDQHNLVACQINDQIFYRAVADIDPGEEL 139
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 693-715 2.10e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.51  E-value: 2.10e-03
                           10        20
                   ....*....|....*....|...
gi 1958666871  693 HACEQCGKSFARKDMLKEHMRVH 715
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
655-717 6.60e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.45  E-value: 6.60e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958666871  655 LPDPNVQKYIHPCEICGRIFNSIGNLERHKLIHTGVKSHACEQCGKSFARKDM--LKEHMRVHDN 717
Cdd:COG5048     24 LKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPleLSRHLRTHHN 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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