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Conserved domains on  [gi|2062451081|ref|XP_042071064|]
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LOW QUALITY PROTEIN: leishmanolysin-like peptidase 2 [Haplochromis burtoni]

Protein Classification

M8 family metallopeptidase( domain architecture ID 140073)

M8 family metallopeptidase such as the metallo-endopeptidase leishmanolysin, a zinc metallopeptidase with the zinb-binding HEXXH motif and a more C-terminal His residue that is the third ligand of zinc

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Peptidase_M8 super family cl19482
Leishmanolysin;
170-514 7.78e-29

Leishmanolysin;


The actual alignment was detected with superfamily member pfam01457:

Pssm-ID: 388572 [Multi-domain]  Cd Length: 529  Bit Score: 119.57  E-value: 7.78e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062451081 170 VP-QPSVLAYAVHCQTDSHGRPVAGVVVIcrDRLTGATYSHQTTVQTVIHELFHALGFSKDLFSTWRdcysssssQVGAD 248
Cdd:pfam01457 174 VPsEGGVLAWAFDCQLFPDGRPAVGVINI--PAAYIVSAYDQFMVRVVTHELAHALGFSLTFFEMLG--------IIGEV 243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062451081 249 CSPRGKASHSDgsghmRIYTPSVISALQKHlvssdpelggplenlvlhsFKCRNFNKLKRKPNGAftpqdaaPGRVSSHW 328
Cdd:pfam01457 244 KNLRGRDYLVP-----VLNSPTVVAKAREQ-------------------YGCPTLEGLELEDQGG-------PGTAGSHL 292

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062451081 329 ESRVLQGSIMSavlGDPSTVRIDPVTLAALQDTGWYTVDLSRAQSLVWGDGEGAMFGSLSTCQDNSSSF---FCTGSGRG 405
Cdd:pfam01457 293 KKRNAKDELMA---PAVGAGYYSALTMAVFQDLGFYQADFTKAEVMPWGNNAGCDFLTKKCMEDNITQWpemFCNSTERA 369

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062451081 406 --CHFLHLHKGECQ----------------------TDQYLEGCRVYKPLQNGSeCWKKESSRWTAEDElsGESFGFDSR 461
Cdd:pfam01457 370 lrCPTDRLSLGTCSitrhpdplptyfqyftdpslggGSMFMDYCPYIVGYSNGA-CNQDPSTASPSLME--FNVFSDASR 446

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2062451081 462 CFLSSLSTQNQSQVSSSVEGRCYRHRC-TGPNRYQIQVFGSE-WVDCPAGGNIQV 514
Cdd:pfam01457 447 CLDGVFRPKHSTGITYPYNGLCANVRCdRAHHTYSVQVYGSSgYVACTPGESVEL 501
 
Name Accession Description Interval E-value
Peptidase_M8 pfam01457
Leishmanolysin;
170-514 7.78e-29

Leishmanolysin;


Pssm-ID: 366652 [Multi-domain]  Cd Length: 529  Bit Score: 119.57  E-value: 7.78e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062451081 170 VP-QPSVLAYAVHCQTDSHGRPVAGVVVIcrDRLTGATYSHQTTVQTVIHELFHALGFSKDLFSTWRdcysssssQVGAD 248
Cdd:pfam01457 174 VPsEGGVLAWAFDCQLFPDGRPAVGVINI--PAAYIVSAYDQFMVRVVTHELAHALGFSLTFFEMLG--------IIGEV 243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062451081 249 CSPRGKASHSDgsghmRIYTPSVISALQKHlvssdpelggplenlvlhsFKCRNFNKLKRKPNGAftpqdaaPGRVSSHW 328
Cdd:pfam01457 244 KNLRGRDYLVP-----VLNSPTVVAKAREQ-------------------YGCPTLEGLELEDQGG-------PGTAGSHL 292

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062451081 329 ESRVLQGSIMSavlGDPSTVRIDPVTLAALQDTGWYTVDLSRAQSLVWGDGEGAMFGSLSTCQDNSSSF---FCTGSGRG 405
Cdd:pfam01457 293 KKRNAKDELMA---PAVGAGYYSALTMAVFQDLGFYQADFTKAEVMPWGNNAGCDFLTKKCMEDNITQWpemFCNSTERA 369

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062451081 406 --CHFLHLHKGECQ----------------------TDQYLEGCRVYKPLQNGSeCWKKESSRWTAEDElsGESFGFDSR 461
Cdd:pfam01457 370 lrCPTDRLSLGTCSitrhpdplptyfqyftdpslggGSMFMDYCPYIVGYSNGA-CNQDPSTASPSLME--FNVFSDASR 446

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2062451081 462 CFLSSLSTQNQSQVSSSVEGRCYRHRC-TGPNRYQIQVFGSE-WVDCPAGGNIQV 514
Cdd:pfam01457 447 CLDGVFRPKHSTGITYPYNGLCANVRCdRAHHTYSVQVYGSSgYVACTPGESVEL 501
PTZ00257 PTZ00257
Glycoprotein GP63 (leishmanolysin); Provisional
 170-514 1.48e-12

Glycoprotein GP63 (leishmanolysin); Provisional


Pssm-ID: 240333  Cd Length: 622  Bit Score: 70.12  E-value: 1.48e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062451081 170 VP-QPSVLAYAVHCQTDSHGRPVAGVVVICRDRLTgATYShQTTVQTVIHELFHALGFSKDLFstwrdcysSSSSQVGAD 248
Cdd:PTZ00257  215 VPsEPGVLAWATTCQVFSDDHPAVGVMNIPAANIV-SRYD-QGTTRTVTHEVAHALGFSSVFF--------ENAGIVKSV 284

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062451081 249 CSPRGKAshsdgsghmriYTPSVISAlqKHLVSSDPElggplenlvlhSFKCRNFNKLKRKPNGaftpqdaAPGRVSSHW 328
Cdd:PTZ00257  285 TNLRGKP-----------FAAPVINS--STAVAKARE-----------QYGCPTLEYLEVEDQG-------GSGSAGSHL 333

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062451081 329 ESRVLQGSIMSavlgdPSTVR--IDPVTLAALQDTGWYTVDLSRAQSLVWGDGEGAMFGSLSTCQDNSSSF---FCTGSG 403
Cdd:PTZ00257  334 KGRNAKDELMA-----PASAAgyYTALTMAVFEDLGFYKADFSMAEVMPWGRNASCDFLTNKCMEDNITQWpemFCNTTE 408

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062451081 404 RG--CHFLHLHKGECQ---------------TDQYLEG-------CRVYKPLQNGSeCWKKESSRWTAEDELSgeSFGFD 459
Cdd:PTZ00257  409 RRyrCPTDRLKLGTCGirtystpmptyfqyfTNAFLGGfsafldyCPFIVGYSNGA-CNQDPSTASPSLKEFN--VFSDA 485

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2062451081 460 SRCFLSSLSTQNQSQVSSSVEGRCYRHRC-TGPNRYQIQVFGSE-WVDCPAGGNIQV 514
Cdd:PTZ00257  486 ARCLDGVFQPRNSNARSEPNNALCANVMCdTAARTYSVQVRGSSgYVACTPGESIDL 542
 
Name Accession Description Interval E-value
Peptidase_M8 pfam01457
Leishmanolysin;
170-514 7.78e-29

Leishmanolysin;


Pssm-ID: 366652 [Multi-domain]  Cd Length: 529  Bit Score: 119.57  E-value: 7.78e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062451081 170 VP-QPSVLAYAVHCQTDSHGRPVAGVVVIcrDRLTGATYSHQTTVQTVIHELFHALGFSKDLFSTWRdcysssssQVGAD 248
Cdd:pfam01457 174 VPsEGGVLAWAFDCQLFPDGRPAVGVINI--PAAYIVSAYDQFMVRVVTHELAHALGFSLTFFEMLG--------IIGEV 243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062451081 249 CSPRGKASHSDgsghmRIYTPSVISALQKHlvssdpelggplenlvlhsFKCRNFNKLKRKPNGAftpqdaaPGRVSSHW 328
Cdd:pfam01457 244 KNLRGRDYLVP-----VLNSPTVVAKAREQ-------------------YGCPTLEGLELEDQGG-------PGTAGSHL 292

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062451081 329 ESRVLQGSIMSavlGDPSTVRIDPVTLAALQDTGWYTVDLSRAQSLVWGDGEGAMFGSLSTCQDNSSSF---FCTGSGRG 405
Cdd:pfam01457 293 KKRNAKDELMA---PAVGAGYYSALTMAVFQDLGFYQADFTKAEVMPWGNNAGCDFLTKKCMEDNITQWpemFCNSTERA 369

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062451081 406 --CHFLHLHKGECQ----------------------TDQYLEGCRVYKPLQNGSeCWKKESSRWTAEDElsGESFGFDSR 461
Cdd:pfam01457 370 lrCPTDRLSLGTCSitrhpdplptyfqyftdpslggGSMFMDYCPYIVGYSNGA-CNQDPSTASPSLME--FNVFSDASR 446

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2062451081 462 CFLSSLSTQNQSQVSSSVEGRCYRHRC-TGPNRYQIQVFGSE-WVDCPAGGNIQV 514
Cdd:pfam01457 447 CLDGVFRPKHSTGITYPYNGLCANVRCdRAHHTYSVQVYGSSgYVACTPGESVEL 501
PTZ00257 PTZ00257
Glycoprotein GP63 (leishmanolysin); Provisional
 170-514 1.48e-12

Glycoprotein GP63 (leishmanolysin); Provisional


Pssm-ID: 240333  Cd Length: 622  Bit Score: 70.12  E-value: 1.48e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062451081 170 VP-QPSVLAYAVHCQTDSHGRPVAGVVVICRDRLTgATYShQTTVQTVIHELFHALGFSKDLFstwrdcysSSSSQVGAD 248
Cdd:PTZ00257  215 VPsEPGVLAWATTCQVFSDDHPAVGVMNIPAANIV-SRYD-QGTTRTVTHEVAHALGFSSVFF--------ENAGIVKSV 284

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062451081 249 CSPRGKAshsdgsghmriYTPSVISAlqKHLVSSDPElggplenlvlhSFKCRNFNKLKRKPNGaftpqdaAPGRVSSHW 328
Cdd:PTZ00257  285 TNLRGKP-----------FAAPVINS--STAVAKARE-----------QYGCPTLEYLEVEDQG-------GSGSAGSHL 333

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062451081 329 ESRVLQGSIMSavlgdPSTVR--IDPVTLAALQDTGWYTVDLSRAQSLVWGDGEGAMFGSLSTCQDNSSSF---FCTGSG 403
Cdd:PTZ00257  334 KGRNAKDELMA-----PASAAgyYTALTMAVFEDLGFYKADFSMAEVMPWGRNASCDFLTNKCMEDNITQWpemFCNTTE 408

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062451081 404 RG--CHFLHLHKGECQ---------------TDQYLEG-------CRVYKPLQNGSeCWKKESSRWTAEDELSgeSFGFD 459
Cdd:PTZ00257  409 RRyrCPTDRLKLGTCGirtystpmptyfqyfTNAFLGGfsafldyCPFIVGYSNGA-CNQDPSTASPSLKEFN--VFSDA 485

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2062451081 460 SRCFLSSLSTQNQSQVSSSVEGRCYRHRC-TGPNRYQIQVFGSE-WVDCPAGGNIQV 514
Cdd:PTZ00257  486 ARCLDGVFQPRNSNARSEPNNALCANVMCdTAARTYSVQVRGSSgYVACTPGESIDL 542
PTZ00337 PTZ00337
surface protease GP63; Provisional
 86-381 2.25e-07

surface protease GP63; Provisional


Pssm-ID: 185563  Cd Length: 567  Bit Score: 53.37  E-value: 2.25e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062451081  86 ESDSLSEAEKG-RLEAAVEEAVRVVSSLLSVNRVPGPLLLSRDINKYCkflwrDSNTINYnriffkasKLNFAHVAFTCS 164
Cdd:PTZ00337  118 ADDVLTEERRSiILRQTLPAAIQLHAERLSVRPVTRPVLIPRTGLGMC-----DNFTIPH--------KHHTVGVAGADM 184

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062451081 165 SVYL-LVPQPSVLAYAVHCQTDSHGRPVAGVVVICRDRLTgATYSHqttVQTVIHELFHALGFSKDLFSTWrdcysssss 243
Cdd:PTZ00337  185 ILYAnIFPTSGPAAWAIPCFLLDDGRPFAAAVNFDPRQIA-VTNGD---VRVAAHELGHALGFVRDQFLML--------- 251

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062451081 244 qvgadcsprgkashsdgsgHMRIYTPSViSALQKHLVSSDPELggplENLVLHSFKCRNFNKLKRKPNGAftpqdaaPGR 323
Cdd:PTZ00337  252 -------------------HMISEVPNV-RGMSKVSVISTPKT----KAMARQYHNCPTLEGIELEDEGG-------PGT 300

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2062451081 324 VSSHWESRVLQGSIMSAVLGdpsTVRIDPVTLAALQDTGWYTVDLSRAQSLVWGDGEG 381
Cdd:PTZ00337  301 ALSHWKKRNMRDEMMTSDVG---VGLYSALTLAAFEDMGVYLANYSAAEMLWWGNNSG 355
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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