NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2092300426|ref|XP_043349067|]
View 

zinc finger protein 711 isoform X5 [Dermochelys coriacea]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Zfx_Zfy_act pfam04704
Zfx / Zfy transcription activation region; Zfx and Zfy are transcription factors implicated in ...
 65-414 6.03e-154

Zfx / Zfy transcription activation region; Zfx and Zfy are transcription factors implicated in mammalian sex determination. This region is found N terminal to multiple copies of a C2H2 Zinc finger (pfam00096). This region has been shown to activate transcription when fused to a GAL4 DNA binding domain.


:

Pssm-ID: 461400  Cd Length: 328  Bit Score: 441.22  E-value: 6.03e-154
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2092300426  65 GLAAEVVQGPDIITETDVVtEGVIVPESVLEADVAIEEDLDTS---DHVLTSDLITETVRVPDQVFVADLVTGPD-GHLE 140
Cdd:pfam04704   1 DVVIEDVQCPDILEETDVS-EGVIIPEQVLDSEVAIEVSLDHCtvpDDVLTSDLISESMTMPEQVFVAELVSVPEvGHLE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2092300426 141 HVVQDS----VSGADSPTMVSEEVLVTNSDTETVIQAastvpgSTVTIKTEDDDdgKSTSEDYLMISLDDvGEKLDHIGS 216
Cdd:pfam04704  80 HVIHDSereiVTDALTADMVSEEVLVADCASEAVIDA------SGVPLETQDDD--KSNCEDYLMISLDD-GEKLDHIGS 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2092300426 217 TPLKISTEVShDDVSKDDGFGSEVIKVYIFKAEAEDDvEIGGTEIVTESDFHNGHSVAGViEQGAVGRMQREKMVYMAVK 296
Cdd:pfam04704 151 TPLTMSAEVE-QDSSKLDGFCPEVIKVYIFKADPGED-DLGGTEDIVESEFENGHGVLLL-EQGSSGRLPREKMVYMAVK 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2092300426 297 DSSQEDEDISCAEIADEVYMEVIVGEEEATSLPDTQLEDSGVNKTFVPVAWAAAYgderrlprryedcqaaGNNLDtRLE 376
Cdd:pfam04704 228 DSQQEDEDLNVAEIADEVYMEVIVGEEDAAVAHEQQLDDSEVNKTFMPIAWAAAY----------------GNNTD-GIE 290

                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 2092300426 377 NKNGNAAQYLQICDSINTNRALKQKAKKRRRGETRQWQ 414
Cdd:pfam04704 291 NKNGTASALLHIDESASLDRLLKQKPKKKRRGESRQYQ 328
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 429-451 1.42e-06

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 44.60  E-value: 1.42e-06
                          10        20
                  ....*....|....*....|...
gi 2092300426 429 YPCHICGKKFKSRGFLKRHMKNH 451
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
Zfx_Zfy_act pfam04704
Zfx / Zfy transcription activation region; Zfx and Zfy are transcription factors implicated in ...
 65-414 6.03e-154

Zfx / Zfy transcription activation region; Zfx and Zfy are transcription factors implicated in mammalian sex determination. This region is found N terminal to multiple copies of a C2H2 Zinc finger (pfam00096). This region has been shown to activate transcription when fused to a GAL4 DNA binding domain.


Pssm-ID: 461400  Cd Length: 328  Bit Score: 441.22  E-value: 6.03e-154
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2092300426  65 GLAAEVVQGPDIITETDVVtEGVIVPESVLEADVAIEEDLDTS---DHVLTSDLITETVRVPDQVFVADLVTGPD-GHLE 140
Cdd:pfam04704   1 DVVIEDVQCPDILEETDVS-EGVIIPEQVLDSEVAIEVSLDHCtvpDDVLTSDLISESMTMPEQVFVAELVSVPEvGHLE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2092300426 141 HVVQDS----VSGADSPTMVSEEVLVTNSDTETVIQAastvpgSTVTIKTEDDDdgKSTSEDYLMISLDDvGEKLDHIGS 216
Cdd:pfam04704  80 HVIHDSereiVTDALTADMVSEEVLVADCASEAVIDA------SGVPLETQDDD--KSNCEDYLMISLDD-GEKLDHIGS 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2092300426 217 TPLKISTEVShDDVSKDDGFGSEVIKVYIFKAEAEDDvEIGGTEIVTESDFHNGHSVAGViEQGAVGRMQREKMVYMAVK 296
Cdd:pfam04704 151 TPLTMSAEVE-QDSSKLDGFCPEVIKVYIFKADPGED-DLGGTEDIVESEFENGHGVLLL-EQGSSGRLPREKMVYMAVK 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2092300426 297 DSSQEDEDISCAEIADEVYMEVIVGEEEATSLPDTQLEDSGVNKTFVPVAWAAAYgderrlprryedcqaaGNNLDtRLE 376
Cdd:pfam04704 228 DSQQEDEDLNVAEIADEVYMEVIVGEEDAAVAHEQQLDDSEVNKTFMPIAWAAAY----------------GNNTD-GIE 290

                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 2092300426 377 NKNGNAAQYLQICDSINTNRALKQKAKKRRRGETRQWQ 414
Cdd:pfam04704 291 NKNGTASALLHIDESASLDRLLKQKPKKKRRGESRQYQ 328
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 429-451 1.42e-06

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 44.60  E-value: 1.42e-06
                          10        20
                  ....*....|....*....|...
gi 2092300426 429 YPCHICGKKFKSRGFLKRHMKNH 451
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
ZnF_C2H2 smart00355
zinc finger;
429-451 3.19e-05

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 40.53  E-value: 3.19e-05
                           10        20
                   ....*....|....*....|...
gi 2092300426  429 YPCHICGKKFKSRGFLKRHMKNH 451
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
 
Name Accession Description Interval E-value
Zfx_Zfy_act pfam04704
Zfx / Zfy transcription activation region; Zfx and Zfy are transcription factors implicated in ...
 65-414 6.03e-154

Zfx / Zfy transcription activation region; Zfx and Zfy are transcription factors implicated in mammalian sex determination. This region is found N terminal to multiple copies of a C2H2 Zinc finger (pfam00096). This region has been shown to activate transcription when fused to a GAL4 DNA binding domain.


Pssm-ID: 461400  Cd Length: 328  Bit Score: 441.22  E-value: 6.03e-154
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2092300426  65 GLAAEVVQGPDIITETDVVtEGVIVPESVLEADVAIEEDLDTS---DHVLTSDLITETVRVPDQVFVADLVTGPD-GHLE 140
Cdd:pfam04704   1 DVVIEDVQCPDILEETDVS-EGVIIPEQVLDSEVAIEVSLDHCtvpDDVLTSDLISESMTMPEQVFVAELVSVPEvGHLE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2092300426 141 HVVQDS----VSGADSPTMVSEEVLVTNSDTETVIQAastvpgSTVTIKTEDDDdgKSTSEDYLMISLDDvGEKLDHIGS 216
Cdd:pfam04704  80 HVIHDSereiVTDALTADMVSEEVLVADCASEAVIDA------SGVPLETQDDD--KSNCEDYLMISLDD-GEKLDHIGS 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2092300426 217 TPLKISTEVShDDVSKDDGFGSEVIKVYIFKAEAEDDvEIGGTEIVTESDFHNGHSVAGViEQGAVGRMQREKMVYMAVK 296
Cdd:pfam04704 151 TPLTMSAEVE-QDSSKLDGFCPEVIKVYIFKADPGED-DLGGTEDIVESEFENGHGVLLL-EQGSSGRLPREKMVYMAVK 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2092300426 297 DSSQEDEDISCAEIADEVYMEVIVGEEEATSLPDTQLEDSGVNKTFVPVAWAAAYgderrlprryedcqaaGNNLDtRLE 376
Cdd:pfam04704 228 DSQQEDEDLNVAEIADEVYMEVIVGEEDAAVAHEQQLDDSEVNKTFMPIAWAAAY----------------GNNTD-GIE 290

                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 2092300426 377 NKNGNAAQYLQICDSINTNRALKQKAKKRRRGETRQWQ 414
Cdd:pfam04704 291 NKNGTASALLHIDESASLDRLLKQKPKKKRRGESRQYQ 328
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 429-451 1.42e-06

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 44.60  E-value: 1.42e-06
                          10        20
                  ....*....|....*....|...
gi 2092300426 429 YPCHICGKKFKSRGFLKRHMKNH 451
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2_4 pfam13894
C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.
 429-451 3.14e-05

C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.


Pssm-ID: 464025  Cd Length: 24  Bit Score: 40.70  E-value: 3.14e-05
                          10        20
                  ....*....|....*....|...
gi 2092300426 429 YPCHICGKKFKSRGFLKRHMKNH 451
Cdd:pfam13894   1 FKCPICGKSFSSKKSLKRHLKTH 23
ZnF_C2H2 smart00355
zinc finger;
429-451 3.19e-05

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 40.53  E-value: 3.19e-05
                           10        20
                   ....*....|....*....|...
gi 2092300426  429 YPCHICGKKFKSRGFLKRHMKNH 451
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH