NCBI Conserved Domain Search

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of Golgi-associated plant pathogenesis-related protein 1 and similar proteins; Golgi-associated plant pathogenesis related protein 1 (GAPR1), also called Golgi-associated PR-1 protein or glioma pathogenesis-related protein 2 (GLIPR-2), forms amyloid-like fibrils in the presence of liposomes containing acidic phospholipids. It has been identified in mice as an up-regulated protein in kidney fibrosis, and is involved in epithelial to mesenchymal transition and in generating a pool of myofibroblasts contributing to fibrosis. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.

Pssm-ID: 349401 Cd Length: 132 Bit Score: 220.16 E-value: 2.69e-67

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615 402 NFEQEALDTHNKYRRLHGAPPLQLSRELCESSQKWANHLLSINALQHS-NTNHGENLWYKWNSSvRDASGSEVVDTWYNE 480
Cdd:cd05382     1 VFQKECLKAHNEYRALHGAPPLKLDKELSKEAQKWAEKLASSGTLQHSsPSSYGENLAYFSGSG-YDLTGEEAVDSWYNE 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2113642615 481 IKDYNFSKPGFQSNTGHFTQVVWKDSREVGIAKAVDGKGMVIAVAQYSPAGNI 533
Cdd:cd05382    80 IKNYNFNKPGFQSGTGHFTQVVWKSSTELGVGVAKSKDGCVYVVARYSPAGNV 132

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of Golgi-associated plant pathogenesis-related protein 1 and similar proteins; Golgi-associated plant pathogenesis related protein 1 (GAPR1), also called Golgi-associated PR-1 protein or glioma pathogenesis-related protein 2 (GLIPR-2), forms amyloid-like fibrils in the presence of liposomes containing acidic phospholipids. It has been identified in mice as an up-regulated protein in kidney fibrosis, and is involved in epithelial to mesenchymal transition and in generating a pool of myofibroblasts contributing to fibrosis. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.

Pssm-ID: 349401 Cd Length: 132 Bit Score: 212.46 E-value: 1.79e-64

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615  21 QFEQDFLDAHNKYRALHGSPPLQLNTDLCESSQKWADHLLSIRTVRHSDT-EYGENIDYKSSSSPKvLAGNAPVDSWYSE 99
Cdd:cd05382     1 VFQKECLKAHNEYRALHGAPPLKLDKELSKEAQKWAEKLASSGTLQHSSPsSYGENLAYFSGSGYD-LTGEEAVDSWYNE 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2113642615 100 IKNYDFSKPGFSVSTGHFTQVVWKESKEVGFGVATDSKKAYYVVAQYNPSGNM 152
Cdd:cd05382    80 IKNYNFNKPGFQSGTGHFTQVVWKSSTELGVGVAKSKDGCVYVVARYSPAGNV 132

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of Golgi-associated plant pathogenesis-related protein 1 and similar proteins; Golgi-associated plant pathogenesis related protein 1 (GAPR1), also called Golgi-associated PR-1 protein or glioma pathogenesis-related protein 2 (GLIPR-2), forms amyloid-like fibrils in the presence of liposomes containing acidic phospholipids. It has been identified in mice as an up-regulated protein in kidney fibrosis, and is involved in epithelial to mesenchymal transition and in generating a pool of myofibroblasts contributing to fibrosis. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.

Pssm-ID: 349401 Cd Length: 132 Bit Score: 212.08 E-value: 2.79e-64

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615 211 QFEKDFVSAHNIYRKKHGAPPLQLNRDLCRSAQAWADHLLSIQTLKHS-GTDHGENLYYKYSSSTrELPGQEPVESWYDE 289
Cdd:cd05382     1 VFQKECLKAHNEYRALHGAPPLKLDKELSKEAQKWAEKLASSGTLQHSsPSSYGENLAYFSGSGY-DLTGEEAVDSWYNE 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2113642615 290 IKNYDFGRPGFRSNTGHFTQVVWKDSKEVGVGIATDGNGLFFVVGQYNPAGNI 342
Cdd:cd05382    80 IKNYNFNKPGFQSGTGHFTQVVWKSSTELGVGVAKSKDGCVYVVARYSPAGNV 132

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of Golgi-associated plant pathogenesis-related protein 1 and similar proteins; Golgi-associated plant pathogenesis related protein 1 (GAPR1), also called Golgi-associated PR-1 protein or glioma pathogenesis-related protein 2 (GLIPR-2), forms amyloid-like fibrils in the presence of liposomes containing acidic phospholipids. It has been identified in mice as an up-regulated protein in kidney fibrosis, and is involved in epithelial to mesenchymal transition and in generating a pool of myofibroblasts contributing to fibrosis. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.

Pssm-ID: 349401 Cd Length: 132 Bit Score: 197.05 E-value: 7.73e-59

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615 587 FAKEFLKANNAYRSQHGAKPLQLSTRISQDAQKWAEHLLTLKTLKHSDTS-CGENIWAKTGSPSiTVTGQEVADSWYKEE 665
Cdd:cd05382     2 FQKECLKAHNEYRALHGAPPLKLDKELSKEAQKWAEKLASSGTLQHSSPSsYGENLAYFSGSGY-DLTGEEAVDSWYNEI 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2113642615 666 KNYNFFKPGHQPDTGHFTQMVWKASKEVGVGIASSGKGMFIVVAQYHPCGNI 717
Cdd:cd05382    81 KNYNFNKPGFQSGTGHFTQVVWKSSTELGVGVAKSKDGCVYVVARYSPAGNV 132

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of Golgi-associated plant pathogenesis-related protein 1 and similar proteins; Golgi-associated plant pathogenesis related protein 1 (GAPR1), also called Golgi-associated PR-1 protein or glioma pathogenesis-related protein 2 (GLIPR-2), forms amyloid-like fibrils in the presence of liposomes containing acidic phospholipids. It has been identified in mice as an up-regulated protein in kidney fibrosis, and is involved in epithelial to mesenchymal transition and in generating a pool of myofibroblasts contributing to fibrosis. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.

Pssm-ID: 349401 Cd Length: 132 Bit Score: 193.20 E-value: 2.07e-57

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615 764 FRKDLLNEHNKYRRVHGSGALQLTTPLTQEAQKWADHLVGVRALQNSST-EHGENLWYRWGTDTSlPTGKEVAESWYNEI 842
Cdd:cd05382     2 FQKECLKAHNEYRALHGAPPLKLDKELSKEAQKWAEKLASSGTLQHSSPsSYGENLAYFSGSGYD-LTGEEAVDSWYNEI 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2113642615 843 SKYNFSTPGFQSGSGNFTQMVWKGSTQVGFGLSTDNKGMYISVGFYDPAGNI 894
Cdd:cd05382    81 KNYNFNKPGFQSGTGHFTQVVWKSSTELGVGVAKSKDGCVYVVARYSPAGNV 132

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of pathogen-related yeast 1 (PRY1) protein and similar fungal proteins; PRY1, also called pathogenesis-related protein 1, is a yeast protein that is up-regulated in core ESCRT mutants. It is a secreted protein required for efficient export of lipids such as acetylated sterols, and acts in detoxification of hydrophobic compounds. This PRY1-like group also contains fruiting body proteins SC7/14 from Schizophyllum commune. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.

Pssm-ID: 349403 Cd Length: 129 Bit Score: 144.78 E-value: 2.51e-40

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615  21 QFEQDFLDAHNKYRALHGSPPLQLNTDLCESSQKWADHLLSIRTVRHSDTEYGENIDYKSSSspkvlaGNAPVDSWYSEI 100
Cdd:cd05384     1 SFASSILDAHNKKRALHGTQPLTWNDTLAEYAQDYADSYDCSGNLVHSGGPYGENLALGYSS------GAAAVDAWYDEI 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2113642615 101 KNYDFSKPGFSVSTGHFTQVVWKESKEVGFGVAT-DSKKAYYVVAQYNPSGNM 152
Cdd:cd05384    75 SDYDYSNPGFSESTGHFTQLVWKSTTQVGCAYKDcGGAWGLYIVCEYDPAGNV 127

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of pathogen-related yeast 1 (PRY1) protein and similar fungal proteins; PRY1, also called pathogenesis-related protein 1, is a yeast protein that is up-regulated in core ESCRT mutants. It is a secreted protein required for efficient export of lipids such as acetylated sterols, and acts in detoxification of hydrophobic compounds. This PRY1-like group also contains fruiting body proteins SC7/14 from Schizophyllum commune. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.

Pssm-ID: 349403 Cd Length: 129 Bit Score: 143.24 E-value: 8.14e-40

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615 402 NFEQEALDTHNKYRRLHGAPPLQLSRELCESSQKWANHLLSINALQHSNTNHGENLWYKWNSsvrdasGSEVVDTWYNEI 481
Cdd:cd05384     1 SFASSILDAHNKKRALHGTQPLTWNDTLAEYAQDYADSYDCSGNLVHSGGPYGENLALGYSS------GAAAVDAWYDEI 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2113642615 482 KDYNFSKPGFQSNTGHFTQVVWKDSREVGIA-KAVDGKGMVIAVAQYSPAGNI 533
Cdd:cd05384    75 SDYDYSNPGFSESTGHFTQLVWKSTTQVGCAyKDCGGAWGLYIVCEYDPAGNV 127

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of pathogen-related yeast 1 (PRY1) protein and similar fungal proteins; PRY1, also called pathogenesis-related protein 1, is a yeast protein that is up-regulated in core ESCRT mutants. It is a secreted protein required for efficient export of lipids such as acetylated sterols, and acts in detoxification of hydrophobic compounds. This PRY1-like group also contains fruiting body proteins SC7/14 from Schizophyllum commune. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.

Pssm-ID: 349403 Cd Length: 129 Bit Score: 139.78 E-value: 1.24e-38

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615 211 QFEKDFVSAHNIYRKKHGAPPLQLNRDLCRSAQAWADHLLSIQTLKHSGTDHGENLYYKYSSstrelpGQEPVESWYDEI 290
Cdd:cd05384     1 SFASSILDAHNKKRALHGTQPLTWNDTLAEYAQDYADSYDCSGNLVHSGGPYGENLALGYSS------GAAAVDAWYDEI 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2113642615 291 KNYDFGRPGFRSNTGHFTQVVWKDSKEVGVGIATDGNGL-FFVVGQYNPAGNI 342
Cdd:cd05384    75 SDYDYSNPGFSESTGHFTQLVWKSTTQVGCAYKDCGGAWgLYIVCEYDPAGNV 127

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of pathogen-related yeast 1 (PRY1) protein and similar fungal proteins; PRY1, also called pathogenesis-related protein 1, is a yeast protein that is up-regulated in core ESCRT mutants. It is a secreted protein required for efficient export of lipids such as acetylated sterols, and acts in detoxification of hydrophobic compounds. This PRY1-like group also contains fruiting body proteins SC7/14 from Schizophyllum commune. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.

Pssm-ID: 349403 Cd Length: 129 Bit Score: 120.13 E-value: 1.24e-31

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615 763 TFRKDLLNEHNKYRRVHGSGALQLTTPLTQEAQKWADHLVGVRALQNSSTEHGENLWYrwgtdtSLPTGKEVAESWYNEI 842
Cdd:cd05384     1 SFASSILDAHNKKRALHGTQPLTWNDTLAEYAQDYADSYDCSGNLVHSGGPYGENLAL------GYSSGAAAVDAWYDEI 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2113642615 843 SKYNFSTPGFQSGSGNFTQMVWKGSTQVGFGLST--DNKGMYIsVGFYDPAGNIAN 896
Cdd:cd05384    75 SDYDYSNPGFSESTGHFTQLVWKSTTQVGCAYKDcgGAWGLYI-VCEYDPAGNVIG 129

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of pathogenesis-related protein 1 (PR-1) family proteins; Members of pathogenesis-related protein 1 (PR-1) family are among the most abundantly produced proteins in plants on pathogen attack. They are considered hallmarks of hypersensitive response/defense pathways and may act as anti-fungal agents or be involved in cell wall loosening.

Pssm-ID: 349400 Cd Length: 136 Bit Score: 110.80 E-value: 2.08e-28

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615 405 QEALDTHNKYRRLHGAPPLQLSRELCESSQKWANHLLSINALQHSNTNHGENLWYKWNSSVrdaSGSEVVDTWYNEIKDY 484
Cdd:cd05381     2 QDFLDAHNQARAAVGVPPLVWDDTLAAYAQKYANQRRGDCSLVHSNGPYGENLFWGSGDNW---SPADAVKSWVDEKPYY 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2113642615 485 NFSkpgfqSNT-------GHFTQVVWKDSREVGIAKAV-DGKGMVIAVAQYSPAGNITN 535
Cdd:cd05381    79 DYA-----SNTcvggkmcGHYTQVVWRNSTRLGCARVVcDNNGGTFVICNYDPPGNYIG 132

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of pathogen-related yeast 1 (PRY1) protein and similar fungal proteins; PRY1, also called pathogenesis-related protein 1, is a yeast protein that is up-regulated in core ESCRT mutants. It is a secreted protein required for efficient export of lipids such as acetylated sterols, and acts in detoxification of hydrophobic compounds. This PRY1-like group also contains fruiting body proteins SC7/14 from Schizophyllum commune. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.

Pssm-ID: 349403 Cd Length: 129 Bit Score: 108.19 E-value: 1.62e-27

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615 587 FAKEFLKANNAYRSQHGAKPLQLSTRISQDAQKWAEHLLTLKTLKHSDTSCGENIWAKTGSPsitvtgQEVADSWYKEEK 666
Cdd:cd05384     2 FASSILDAHNKKRALHGTQPLTWNDTLAEYAQDYADSYDCSGNLVHSGGPYGENLALGYSSG------AAAVDAWYDEIS 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2113642615 667 NYNFFKPGHQPDTGHFTQMVWKASKEVGVGI--ASSGKGMFIvVAQYHPCGNI 717
Cdd:cd05384    76 DYDYSNPGFSESTGHFTQLVWKSTTQVGCAYkdCGGAWGLYI-VCEYDPAGNV 127

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of pathogenesis-related protein 1 (PR-1) family proteins; Members of pathogenesis-related protein 1 (PR-1) family are among the most abundantly produced proteins in plants on pathogen attack. They are considered hallmarks of hypersensitive response/defense pathways and may act as anti-fungal agents or be involved in cell wall loosening.

Pssm-ID: 349400 Cd Length: 136 Bit Score: 107.33 E-value: 4.27e-27

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615 214 KDFVSAHNIYRKKHGAPPLQLNRDLCRSAQAWADHLLSIQTLKHSGTDHGENLYYKYSSStreLPGQEPVESWYDEIKNY 293
Cdd:cd05381     2 QDFLDAHNQARAAVGVPPLVWDDTLAAYAQKYANQRRGDCSLVHSNGPYGENLFWGSGDN---WSPADAVKSWVDEKPYY 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2113642615 294 DFGrpgfrSNT-------GHFTQVVWKDSKEVGVGIAT-DGNGLFFVVGQYNPAGNITN 344
Cdd:cd05381    79 DYA-----SNTcvggkmcGHYTQVVWRNSTRLGCARVVcDNNGGTFVICNYDPPGNYIG 132

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of pathogenesis-related protein 1 (PR-1) family proteins; Members of pathogenesis-related protein 1 (PR-1) family are among the most abundantly produced proteins in plants on pathogen attack. They are considered hallmarks of hypersensitive response/defense pathways and may act as anti-fungal agents or be involved in cell wall loosening.

Pssm-ID: 349400 Cd Length: 136 Bit Score: 101.94 E-value: 3.29e-25

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615  24 QDFLDAHNKYRALHGSPPLQLNTDLCESSQKWADHLLSIRTVRHSDTEYGENI--DYKSSSSPKvlagnAPVDSWYSEIK 101
Cdd:cd05381     2 QDFLDAHNQARAAVGVPPLVWDDTLAAYAQKYANQRRGDCSLVHSNGPYGENLfwGSGDNWSPA-----DAVKSWVDEKP 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2113642615 102 NYDFS----KPGFSVstGHFTQVVWKESKEVGFGVAT-DSKKAYYVVAQYNPSGN 151
Cdd:cd05381    77 YYDYAsntcVGGKMC--GHYTQVVWRNSTRLGCARVVcDNNGGTFVICNYDPPGN 129

SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains; Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has no known function.

Pssm-ID: 214553 [Multi-domain] Cd Length: 144 Bit Score: 94.76 E-value: 1.39e-22

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615   21 QFEQDFLDAHNKYRALHGS-----------PPLQLNTDLCESSQKWADHLLSirtvRHS--DTEYGENIDYKSSS--SPK 85
Cdd:smart00198   1 AQQQEILDAHNKLRSQVAGgflaapaasnmLKLTWDCELASSAQNWANQCPF----GHStpRPGYGENLAWWSSStaLPD 76

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2113642615   86 VLAGNApVDSWYSEIKNYDFSKPGF---SVSTGHFTQVVWKESKEVGFGVAT---DSKKAYYVVAQYNP 148
Cdd:smart00198  77 TYASAA-VQLWYDEFQDYGYSSNTCkdtNGKIGHYTQVVWAKTYKVGCGVANcpdGTKKKTVVVCNYDP 144

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of pathogenesis-related protein 1 (PR-1) family proteins; Members of pathogenesis-related protein 1 (PR-1) family are among the most abundantly produced proteins in plants on pathogen attack. They are considered hallmarks of hypersensitive response/defense pathways and may act as anti-fungal agents or be involved in cell wall loosening.

Pssm-ID: 349400 Cd Length: 136 Bit Score: 92.70 E-value: 5.83e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615 588 AKEFLKANNAYRSQHGAKPLQLSTRISQDAQKWAEHLLTLKTLKHSDTSCGENIWAKTGSpsiTVTGQEVADSWYKEEKN 667
Cdd:cd05381     1 PQDFLDAHNQARAAVGVPPLVWDDTLAAYAQKYANQRRGDCSLVHSNGPYGENLFWGSGD---NWSPADAVKSWVDEKPY 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2113642615 668 YNFF----KPGHQpdTGHFTQMVWKASKEVGVGIA--SSGKGMFIvVAQYHPCGNITN 719
Cdd:cd05381    78 YDYAsntcVGGKM--CGHYTQVVWRNSTRLGCARVvcDNNGGTFV-ICNYDPPGNYIG 132

SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains; Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has no known function.

Pssm-ID: 214553 [Multi-domain] Cd Length: 144 Bit Score: 92.45 E-value: 8.19e-22

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615  402 NFEQEALDTHNKYRRLHG-----------APPLQLSRELCESSQKWANHllsiNALQHSN--TNHGENLWYKWNS-SVRD 467
Cdd:smart00198   1 AQQQEILDAHNKLRSQVAggflaapaasnMLKLTWDCELASSAQNWANQ----CPFGHSTprPGYGENLAWWSSStALPD 76

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2113642615  468 ASGSEVVDTWYNEIKDYNFSKPGF---QSNTGHFTQVVWKDSREVGIAKAV---DGKGMVIAVAQYSP 529
Cdd:smart00198  77 TYASAAVQLWYDEFQDYGYSSNTCkdtNGKIGHYTQVVWAKTYKVGCGVANcpdGTKKKTVVVCNYDP 144

SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains; Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has no known function.

Pssm-ID: 214553 [Multi-domain] Cd Length: 144 Bit Score: 91.30 E-value: 2.24e-21

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615  211 QFEKDFVSAHNIYRKKHG-----------APPLQLNRDLCRSAQAWADHLlsiqTLKHSGTDH--GENLYYkYSSSTREL 277
Cdd:smart00198   1 AQQQEILDAHNKLRSQVAggflaapaasnMLKLTWDCELASSAQNWANQC----PFGHSTPRPgyGENLAW-WSSSTALP 75

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2113642615  278 P--GQEPVESWYDEIKNYDFGRPGFR---SNTGHFTQVVWKDSKEVGVGIAT---DGNGLFFVVGQYNP 338
Cdd:smart00198  76 DtyASAAVQLWYDEFQDYGYSSNTCKdtnGKIGHYTQVVWAKTYKVGCGVANcpdGTKKKTVVVCNYDP 144

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of pathogenesis-related protein 1 (PR-1) family proteins; Members of pathogenesis-related protein 1 (PR-1) family are among the most abundantly produced proteins in plants on pathogen attack. They are considered hallmarks of hypersensitive response/defense pathways and may act as anti-fungal agents or be involved in cell wall loosening.

Pssm-ID: 349400 Cd Length: 136 Bit Score: 90.39 E-value: 3.57e-21

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615 766 KDLLNEHNKYRRVHGSGALQLTTPLTQEAQKWADHLVGVRALQNSSTEHGENLWyrWGTDTSLpTGKEVAESWYNEISKY 845
Cdd:cd05381     2 QDFLDAHNQARAAVGVPPLVWDDTLAAYAQKYANQRRGDCSLVHSNGPYGENLF--WGSGDNW-SPADAVKSWVDEKPYY 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2113642615 846 NFST----PGFQsgSGNFTQMVWKGSTQVGFGLST-DNKGMYISVGFYDPAGNIAN 896
Cdd:cd05381    79 DYASntcvGGKM--CGHYTQVVWRNSTRLGCARVVcDNNGGTFVICNYDPPGNYIG 132

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain family; The CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain, also called SCP (sperm-coating glycoprotein), is found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in cell wall loosening. This family also includes CRISPs (cysteine-rich secretory proteins), which combine the CAP/SCP domain with a C-terminal cysteine rich domain, and allergen 5 from vespid venom. Roles for CRISP, in response to pathogens, fertilization, and sperm maturation have been proposed. One member, Tex31 from the venom duct of Conus textile, has been shown to possess proteolytic activity sensitive to serine protease inhibitors. The human GAPR-1 protein has been reported to dimerize, and such a dimer may form an active site containing a catalytic triad. CAP/SCP has also been proposed to be a Ca++ chelating serine protease. The Ca++-chelating function would fit with various signaling processes that members of this family, such as the CRISPs, are involved in, and is supported by sequence and structural evidence of a conserved pocket containing two histidines and a glutamate. It also may explain how helothermine, a toxic peptide secreted by the beaded lizard, blocks Ca++ transporting ryanodine receptors. Little is known about the biological roles of the bacterial and archaeal CAP/SCP domains.

Pssm-ID: 349397 Cd Length: 128 Bit Score: 89.99 E-value: 3.87e-21

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615 216 FVSAHNIYRKKH-----GAPPLQLNRDLCRSAQAWADHLLSIQTLKHSGTDHGENLYYkyssSTRELPGQEPVESWYDEI 290
Cdd:cd00168     4 ILDLHNSYRSSVsppasNMPLMAWDQELADVAIGYAKDCIFSHSSPTSRQLAGENIAA----SSYDMDGVAALQAWHNEI 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2113642615 291 KNYDFGR--PGFRSNTGHFTQVVWKDSKEVGVGIATDGNGLFFVVGQY 336
Cdd:cd00168    80 KNYNFGTaqPGFNSGTGHYTQMVWEKTTKLGCGVADCSDNSKFVVCNY 127

Cysteine-rich secretory protein family; This is a large family of cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins (CAP) that are found in a wide range of organizms, including prokaryotes and non-vertebrate eukaryotes, The nine subfamilies of the mammalian CAP 'super'family include: the human glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), cysteine-rich secretory proteins (CRISPs), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), mannose receptor like and the R3H domain containing like proteins. Members are most often secreted and have an extracellular endocrine or paracrine function and are involved in processes including the regulation of extracellular matrix and branching morphogenesis, potentially as either proteases or protease inhibitors; in ion channel regulation in fertility; as tumour suppressor or pro-oncogenic genes in tissues including the prostate; and in cell-cell adhesion during fertilization. The overall protein structural conservation within the CAP 'super'family results in fundamentally similar functions for the CAP domain in all members, yet the diversity outside of this core region dramatically alters the target specificity and, thus, the biological consequences. The Ca++-chelating function would fit with the various signalling processes (e.g. the CRISP proteins) that members of this family are involved in, and also the sequence and structural evidence of a conserved pocket containing two histidines and a glutamate. It also may explain how Swiss:Q91055 blocks the Ca++ transporting ryanodine receptors.

Pssm-ID: 395136 Cd Length: 117 Bit Score: 88.41 E-value: 9.92e-21

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615 217 VSAHNIYRKKHGAPPLQLNRDLCRSAQAWADHLLSIQTLKHSgTDHGENLYYKYSSSTRELPGQEP------VESWYDEI 290
Cdd:pfam00188   1 LDLHNEYRAAAGLPPLSWDNELAAAAQDHAKYCADNGSHNHR-SPYGGNIYARVVAAGYALGDAGPdsaedaVDGWYDSP 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2113642615 291 KNYdfgrpgfrsNTGHFTQVVWKDSKEVGVGIATDGNG-LFFVVGQY 336
Cdd:pfam00188  80 GTY---------NCGHRTNLLWPKSTKVGCAVAKCGDGgTYYFVCNY 117

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain family; The CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain, also called SCP (sperm-coating glycoprotein), is found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in cell wall loosening. This family also includes CRISPs (cysteine-rich secretory proteins), which combine the CAP/SCP domain with a C-terminal cysteine rich domain, and allergen 5 from vespid venom. Roles for CRISP, in response to pathogens, fertilization, and sperm maturation have been proposed. One member, Tex31 from the venom duct of Conus textile, has been shown to possess proteolytic activity sensitive to serine protease inhibitors. The human GAPR-1 protein has been reported to dimerize, and such a dimer may form an active site containing a catalytic triad. CAP/SCP has also been proposed to be a Ca++ chelating serine protease. The Ca++-chelating function would fit with various signaling processes that members of this family, such as the CRISPs, are involved in, and is supported by sequence and structural evidence of a conserved pocket containing two histidines and a glutamate. It also may explain how helothermine, a toxic peptide secreted by the beaded lizard, blocks Ca++ transporting ryanodine receptors. Little is known about the biological roles of the bacterial and archaeal CAP/SCP domains.

Pssm-ID: 349397 Cd Length: 128 Bit Score: 88.06 E-value: 1.83e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615 590 EFLKANNAYRSQH-----GAKPLQLSTRISQDAQKWAEHLLtlktLKHSDTS----CGENIWAKTGSpsitVTGQEVADS 660
Cdd:cd00168     3 EILDLHNSYRSSVsppasNMPLMAWDQELADVAIGYAKDCI----FSHSSPTsrqlAGENIAASSYD----MDGVAALQA 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2113642615 661 WYKEEKNYNFFKPGHQPD--TGHFTQMVWKASKEVGVGIASSGKGMFIVVAQY 711
Cdd:cd00168    75 WHNEIKNYNFGTAQPGFNsgTGHYTQMVWEKTTKLGCGVADCSDNSKFVVCNY 127

SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains; Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has no known function.

Pssm-ID: 214553 [Multi-domain] Cd Length: 144 Bit Score: 88.21 E-value: 2.36e-20

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615  586 AFAKEFLKANNAYRSQHG-----------AKPLQLSTRISQDAQKWAEHLltlkTLKHS--DTSCGENIWAKTGS-PSIT 651
Cdd:smart00198   1 AQQQEILDAHNKLRSQVAggflaapaasnMLKLTWDCELASSAQNWANQC----PFGHStpRPGYGENLAWWSSStALPD 76

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2113642615  652 VTGQEVADSWYKEEKNYNFFKPG---HQPDTGHFTQMVWKASKEVGVGIASSGKG---MFIVVAQYHP 713
Cdd:smart00198  77 TYASAAVQLWYDEFQDYGYSSNTckdTNGKIGHYTQVVWAKTYKVGCGVANCPDGtkkKTVVVCNYDP 144

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain family; The CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain, also called SCP (sperm-coating glycoprotein), is found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in cell wall loosening. This family also includes CRISPs (cysteine-rich secretory proteins), which combine the CAP/SCP domain with a C-terminal cysteine rich domain, and allergen 5 from vespid venom. Roles for CRISP, in response to pathogens, fertilization, and sperm maturation have been proposed. One member, Tex31 from the venom duct of Conus textile, has been shown to possess proteolytic activity sensitive to serine protease inhibitors. The human GAPR-1 protein has been reported to dimerize, and such a dimer may form an active site containing a catalytic triad. CAP/SCP has also been proposed to be a Ca++ chelating serine protease. The Ca++-chelating function would fit with various signaling processes that members of this family, such as the CRISPs, are involved in, and is supported by sequence and structural evidence of a conserved pocket containing two histidines and a glutamate. It also may explain how helothermine, a toxic peptide secreted by the beaded lizard, blocks Ca++ transporting ryanodine receptors. Little is known about the biological roles of the bacterial and archaeal CAP/SCP domains.

Pssm-ID: 349397 Cd Length: 128 Bit Score: 87.29 E-value: 3.82e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615  24 QDFLDAHNKYRALH-----GSPPLQLNTDLCESSQKWADHLLSIRTVRHSDTEYGENIdYKSSSSpkvLAGNAPVDSWYS 98
Cdd:cd00168     2 QEILDLHNSYRSSVsppasNMPLMAWDQELADVAIGYAKDCIFSHSSPTSRQLAGENI-AASSYD---MDGVAALQAWHN 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2113642615  99 EIKNYDFSK--PGFSVSTGHFTQVVWKESKEVGFGVATDSKKAYYVVAQY 146
Cdd:cd00168    78 EIKNYNFGTaqPGFNSGTGHYTQMVWEKTTKLGCGVADCSDNSKFVVCNY 127

Cysteine-rich secretory protein family; This is a large family of cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins (CAP) that are found in a wide range of organizms, including prokaryotes and non-vertebrate eukaryotes, The nine subfamilies of the mammalian CAP 'super'family include: the human glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), cysteine-rich secretory proteins (CRISPs), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), mannose receptor like and the R3H domain containing like proteins. Members are most often secreted and have an extracellular endocrine or paracrine function and are involved in processes including the regulation of extracellular matrix and branching morphogenesis, potentially as either proteases or protease inhibitors; in ion channel regulation in fertility; as tumour suppressor or pro-oncogenic genes in tissues including the prostate; and in cell-cell adhesion during fertilization. The overall protein structural conservation within the CAP 'super'family results in fundamentally similar functions for the CAP domain in all members, yet the diversity outside of this core region dramatically alters the target specificity and, thus, the biological consequences. The Ca++-chelating function would fit with the various signalling processes (e.g. the CRISP proteins) that members of this family are involved in, and also the sequence and structural evidence of a conserved pocket containing two histidines and a glutamate. It also may explain how Swiss:Q91055 blocks the Ca++ transporting ryanodine receptors.

Pssm-ID: 395136 Cd Length: 117 Bit Score: 86.49 E-value: 4.64e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615 408 LDTHNKYRRLHGAPPLQLSRELCESSQKWANHLLSINALQHsNTNHGENLW------YKWNSSVRDASGSEVVDTWYNEI 481
Cdd:pfam00188   1 LDLHNEYRAAAGLPPLSWDNELAAAAQDHAKYCADNGSHNH-RSPYGGNIYarvvaaGYALGDAGPDSAEDAVDGWYDSP 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2113642615 482 KDYnfskpgfqsNTGHFTQVVWKDSREVGIAKAVDGKGMVIAVAQY 527
Cdd:pfam00188  80 GTY---------NCGHRTNLLWPKSTKVGCAVAKCGDGGTYYFVCN 116

Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins; The CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain is found mainly in eukaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), and allergen 5 from vespid venom.

Pssm-ID: 349399 Cd Length: 144 Bit Score: 86.35 E-value: 1.10e-19

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615  24 QDFLDAHNKYRALHGS------------PPLQLNTDLCESSQKWADHLLSIRTVRHSDTEYGENIDYKSSSSPKVL-AGN 90
Cdd:cd05380     2 QEILDAHNELRSKVAKgklkglppaanmPKLKWDCELAKLAQNWAKTCVFAHSPCRNTGGVGQNLASVSSSGKDLKeLIE 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2113642615  91 APVDSWYSEIKNYDFSK---PGFSVSTGHFTQVVWKESKEVGFGVAT---DSKKAYYVVAQYN 147
Cdd:cd05380    82 DAVNAWFDELKDYGFGSnpnNNFNSGIGHFTQMVWAKTTKVGCAVARcpkGGGNKTYVVCNYS 144

Cysteine-rich secretory protein family; This is a large family of cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins (CAP) that are found in a wide range of organizms, including prokaryotes and non-vertebrate eukaryotes, The nine subfamilies of the mammalian CAP 'super'family include: the human glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), cysteine-rich secretory proteins (CRISPs), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), mannose receptor like and the R3H domain containing like proteins. Members are most often secreted and have an extracellular endocrine or paracrine function and are involved in processes including the regulation of extracellular matrix and branching morphogenesis, potentially as either proteases or protease inhibitors; in ion channel regulation in fertility; as tumour suppressor or pro-oncogenic genes in tissues including the prostate; and in cell-cell adhesion during fertilization. The overall protein structural conservation within the CAP 'super'family results in fundamentally similar functions for the CAP domain in all members, yet the diversity outside of this core region dramatically alters the target specificity and, thus, the biological consequences. The Ca++-chelating function would fit with the various signalling processes (e.g. the CRISP proteins) that members of this family are involved in, and also the sequence and structural evidence of a conserved pocket containing two histidines and a glutamate. It also may explain how Swiss:Q91055 blocks the Ca++ transporting ryanodine receptors.

Pssm-ID: 395136 Cd Length: 117 Bit Score: 84.18 E-value: 2.80e-19

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615  27 LDAHNKYRALHGSPPLQLNTDLCESSQKWADHlLSIRTVRHSDTEYGENI---DYKSSSSPKVLAGNAP---VDSWYSEI 100
Cdd:pfam00188   1 LDLHNEYRAAAGLPPLSWDNELAAAAQDHAKY-CADNGSHNHRSPYGGNIyarVVAAGYALGDAGPDSAedaVDGWYDSP 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2113642615 101 KNYDfskpgfsvsTGHFTQVVWKESKEVGFGVATDSKKAYYVVAQY 146
Cdd:pfam00188  80 GTYN---------CGHRTNLLWPKSTKVGCAVAKCGDGGTYYFVCN 116

Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins; The CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain is found mainly in eukaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), and allergen 5 from vespid venom.

Pssm-ID: 349399 Cd Length: 144 Bit Score: 83.66 E-value: 9.44e-19

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615 214 KDFVSAHNIYRKKH------------GAPPLQLNRDLCRSAQAWADHLLSIQTLKHSGTDHGENLYYKYSSSTRELP-GQ 280
Cdd:cd05380     2 QEILDAHNELRSKVakgklkglppaaNMPKLKWDCELAKLAQNWAKTCVFAHSPCRNTGGVGQNLASVSSSGKDLKElIE 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2113642615 281 EPVESWYDEIKNYDFG---RPGFRSNTGHFTQVVWKDSKEVGVGIAT---DGNGLFFVVGQYN 337
Cdd:cd05380    82 DAVNAWFDELKDYGFGsnpNNNFNSGIGHFTQMVWAKTTKVGCAVARcpkGGGNKTYVVCNYS 144

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain family; The CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain, also called SCP (sperm-coating glycoprotein), is found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in cell wall loosening. This family also includes CRISPs (cysteine-rich secretory proteins), which combine the CAP/SCP domain with a C-terminal cysteine rich domain, and allergen 5 from vespid venom. Roles for CRISP, in response to pathogens, fertilization, and sperm maturation have been proposed. One member, Tex31 from the venom duct of Conus textile, has been shown to possess proteolytic activity sensitive to serine protease inhibitors. The human GAPR-1 protein has been reported to dimerize, and such a dimer may form an active site containing a catalytic triad. CAP/SCP has also been proposed to be a Ca++ chelating serine protease. The Ca++-chelating function would fit with various signaling processes that members of this family, such as the CRISPs, are involved in, and is supported by sequence and structural evidence of a conserved pocket containing two histidines and a glutamate. It also may explain how helothermine, a toxic peptide secreted by the beaded lizard, blocks Ca++ transporting ryanodine receptors. Little is known about the biological roles of the bacterial and archaeal CAP/SCP domains.

Pssm-ID: 349397 Cd Length: 128 Bit Score: 83.05 E-value: 9.83e-19

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615 405 QEALDTHNKYRRLH-----GAPPLQLSRELCESSQKWANHLLSINALQHSNTNHGENLWykWNSSVRDasGSEVVDTWYN 479
Cdd:cd00168     2 QEILDLHNSYRSSVsppasNMPLMAWDQELADVAIGYAKDCIFSHSSPTSRQLAGENIA--ASSYDMD--GVAALQAWHN 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2113642615 480 EIKDYNFSK--PGFQSNTGHFTQVVWKDSREVGIAKAVDGKGMVIAVAQY 527
Cdd:cd00168    78 EIKNYNFGTaqPGFNSGTGHYTQMVWEKTTKLGCGVADCSDNSKFVVCNY 127

Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins; The CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain is found mainly in eukaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), and allergen 5 from vespid venom.

Pssm-ID: 349399 Cd Length: 144 Bit Score: 82.89 E-value: 1.58e-18

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615 405 QEALDTHNKYRRLH------------GAPPLQLSRELCESSQKWANHLLSINALQHSNTNHGENLWYKWNSSVR-DASGS 471
Cdd:cd05380     2 QEILDAHNELRSKVakgklkglppaaNMPKLKWDCELAKLAQNWAKTCVFAHSPCRNTGGVGQNLASVSSSGKDlKELIE 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2113642615 472 EVVDTWYNEIKDYNFSK---PGFQSNTGHFTQVVWKDSREVGIAKAV---DGKGMVIAVAQYS 528
Cdd:cd05380    82 DAVNAWFDELKDYGFGSnpnNNFNSGIGHFTQMVWAKTTKVGCAVARcpkGGGNKTYVVCNYS 144

Cysteine-rich secretory protein family; This is a large family of cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins (CAP) that are found in a wide range of organizms, including prokaryotes and non-vertebrate eukaryotes, The nine subfamilies of the mammalian CAP 'super'family include: the human glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), cysteine-rich secretory proteins (CRISPs), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), mannose receptor like and the R3H domain containing like proteins. Members are most often secreted and have an extracellular endocrine or paracrine function and are involved in processes including the regulation of extracellular matrix and branching morphogenesis, potentially as either proteases or protease inhibitors; in ion channel regulation in fertility; as tumour suppressor or pro-oncogenic genes in tissues including the prostate; and in cell-cell adhesion during fertilization. The overall protein structural conservation within the CAP 'super'family results in fundamentally similar functions for the CAP domain in all members, yet the diversity outside of this core region dramatically alters the target specificity and, thus, the biological consequences. The Ca++-chelating function would fit with the various signalling processes (e.g. the CRISP proteins) that members of this family are involved in, and also the sequence and structural evidence of a conserved pocket containing two histidines and a glutamate. It also may explain how Swiss:Q91055 blocks the Ca++ transporting ryanodine receptors.

Pssm-ID: 395136 Cd Length: 117 Bit Score: 81.87 E-value: 1.93e-18

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615 592 LKANNAYRSQHGAKPLQLSTRISQDAQKWAEHLLTLKTLKHsDTSCGENIWA------KTGSPSITVTGQEVADSWYKEE 665
Cdd:pfam00188   1 LDLHNEYRAAAGLPPLSWDNELAAAAQDHAKYCADNGSHNH-RSPYGGNIYArvvaagYALGDAGPDSAEDAVDGWYDSP 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2113642615 666 KNYNffkpghqpdTGHFTQMVWKASKEVGVGIASSGKG-MFIVVAQY 711
Cdd:pfam00188  80 GTYN---------CGHRTNLLWPKSTKVGCAVAKCGDGgTYYFVCNY 117

SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains; Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has no known function.

Pssm-ID: 214553 [Multi-domain] Cd Length: 144 Bit Score: 82.44 E-value: 2.18e-18

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615  763 TFRKDLLNEHNKYRRVHGSGalQLTTP-------------LTQEAQKWAD-----HlvgvralQNSSTEHGENLWYRWGT 824
Cdd:smart00198   1 AQQQEILDAHNKLRSQVAGG--FLAAPaasnmlkltwdceLASSAQNWANqcpfgH-------STPRPGYGENLAWWSSS 71

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2113642615  825 -DTSLPTGKEVAESWYNEISKYNFSTPGFQSGS---GNFTQMVWKGSTQVGFGLST---DNKGMYISVGFYDP 890
Cdd:smart00198  72 tALPDTYASAAVQLWYDEFQDYGYSSNTCKDTNgkiGHYTQVVWAKTYKVGCGVANcpdGTKKKTVVVCNYDP 144

Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins; The CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain is found mainly in eukaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), and allergen 5 from vespid venom.

Pssm-ID: 349399 Cd Length: 144 Bit Score: 81.73 E-value: 3.95e-18

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615 589 KEFLKANNAYRSQH------------GAKPLQLSTRISQDAQKWAEHLltlkTLKHSDTSC----GENIWAKTGS-PSIT 651
Cdd:cd05380     2 QEILDAHNELRSKVakgklkglppaaNMPKLKWDCELAKLAQNWAKTC----VFAHSPCRNtggvGQNLASVSSSgKDLK 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2113642615 652 VTGQEVADSWYKEEKNYNF---FKPGHQPDTGHFTQMVWKASKEVGVGIASSGKG---MFIVVAQY 711
Cdd:cd05380    78 ELIEDAVNAWFDELKDYGFgsnPNNNFNSGIGHFTQMVWAKTTKVGCAVARCPKGggnKTYVVCNY 143

Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins; The CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain is found mainly in eukaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), and allergen 5 from vespid venom.

Pssm-ID: 349399 Cd Length: 144 Bit Score: 81.73 E-value: 4.19e-18

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615 765 RKDLLNEHNKYRRVHGSGALQLTTP------------LTQEAQKWADHLVgvraLQNSSTEH----GENLWYRWGTDTSL 828
Cdd:cd05380     1 RQEILDAHNELRSKVAKGKLKGLPPaanmpklkwdceLAKLAQNWAKTCV----FAHSPCRNtggvGQNLASVSSSGKDL 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2113642615 829 P-TGKEVAESWYNEISKYNF---STPGFQSGSGNFTQMVWKGSTQVGFGLSTDNKGMY 882
Cdd:cd05380    77 KeLIEDAVNAWFDELKDYGFgsnPNNNFNSGIGHFTQMVWAKTTKVGCAVARCPKGGG 134

Spore germination protein YkwD and related proteins with CAP (CSP/antigen 5/PR1) domain [Cell cycle control, cell division, chromosome partitioning, General function prediction only];

Pssm-ID: 441910 Cd Length: 144 Bit Score: 78.12 E-value: 8.13e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615 201 SSADQGVEGNQFEKDFVSAHNIYRKKHGAPPLQLNRDLCRSAQAWADHLLSIQTLKHSGTD-----------------HG 263
Cdd:COG2340     9 AAAAAPAALSALEQEVLELVNAYRAAAGLPPLTWDPRLTAAARAHAQDMAENGYFSHTGPDgsspfdrlkaagysyraAG 88

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615 264 ENLYYKYSSstrelpGQEPVESWYDeiknydfgrpgfrsNTGHFTQVVWKDSKEVGVGIATDGNGLFFVV 333
Cdd:COG2340    89 ENIAAGYST------AEEAVDGWMN--------------SPGHRANILNPDFTEIGVGVAYGGDGGVYWT 138

Spore germination protein YkwD and related proteins with CAP (CSP/antigen 5/PR1) domain [Cell cycle control, cell division, chromosome partitioning, General function prediction only];

Pssm-ID: 441910 Cd Length: 144 Bit Score: 73.88 E-value: 2.42e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615 577 SSSSTVDPRAFAKEFLKANNAYRSQHGAKPLQLSTRISQDAQKWAEHLLTLKTLKHSD-----------------TSCGE 639
Cdd:COG2340    10 AAAAPAALSALEQEVLELVNAYRAAAGLPPLTWDPRLTAAARAHAQDMAENGYFSHTGpdgsspfdrlkaagysyRAAGE 89

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2113642615 640 NIWAKTGSPsitvtgQEVADSWYKeeknynffkpghqpDTGHFTQMVWKASKEVGVGIASSGKGMFIVVAQY 711
Cdd:COG2340    90 NIAAGYSTA------EEAVDGWMN--------------SPGHRANILNPDFTEIGVGVAYGGDGGVYWTQVF 141

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of glioma pathogenesis-related protein 1 and similar proteins; Glioma pathogenesis-related protein 1 (GLIPR1) is also called related to testes-specific, vespid, and pathogenesis protein 1 (RTVP-1). The GLIPR1 gene has been identified as a p53 target gene and was shown to be methylated and down-regulated in prostate cancer. It is a novel broad-spectrum tumor suppressor whose proapoptotic properties are exerted in part through ROS-JNK signaling. GLIPR1 is composed of a signal peptide that directs its secretion, a CAP domain, and a transmembrane domain. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.

Pssm-ID: 349404 Cd Length: 148 Bit Score: 73.98 E-value: 2.63e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615 403 FEQEALDTHNKYRRlHGAPP----LQLS--RELCESSQKWANH-LLSINA-LQHSNTNH------GENLWYkwnSSVRDA 468
Cdd:cd05385     2 FIDECVRIHNELRS-KVSPPaanmRYMSwdKALAKTARAWARKcKFSHNIcLKEPGKCHpnfttlGENIWL---GSIFSF 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2113642615 469 SGSEVVDTWYNEIKDYNFskpgfQSNT-----GHFTQVVWKDSREVGIAKAVDGKGM--------VIAVAQYSPAG 531
Cdd:cd05385    78 SVESAITSWYNEVKDYNF-----KTNScsrvcGHYTQVVWADSYKVGCAVHVCPNGGgffsgsssAIFVCNYGPAG 148

Spore germination protein YkwD and related proteins with CAP (CSP/antigen 5/PR1) domain [Cell cycle control, cell division, chromosome partitioning, General function prediction only];

Pssm-ID: 441910 Cd Length: 144 Bit Score: 73.49 E-value: 3.11e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615  18 DAKQFEQDFLDAHNKYRALHGSPPLQLNTDLCESSQKWADHLLSIRTVRHSDTEY-----------------GENIDYKS 80
Cdd:COG2340    16 ALSALEQEVLELVNAYRAAAGLPPLTWDPRLTAAARAHAQDMAENGYFSHTGPDGsspfdrlkaagysyraaGENIAAGY 95

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2113642615  81 SSSPKVlagnapVDSWYSeiknydfskpgfsvSTGHFTQVVWKESKEVGFGVATDSKKAYYVVAQY 146
Cdd:COG2340    96 STAEEA------VDGWMN--------------SPGHRANILNPDFTEIGVGVAYGGDGGVYWTQVF 141

Spore germination protein YkwD and related proteins with CAP (CSP/antigen 5/PR1) domain [Cell cycle control, cell division, chromosome partitioning, General function prediction only];

Pssm-ID: 441910 Cd Length: 144 Bit Score: 72.34 E-value: 7.88e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615 390 TAVFGRQAVKLGNFEQEALDTHNKYRRLHGAPPLQLSRELCESSQKWANHLLSINALQHSNTN----------------- 452
Cdd:COG2340     7 LAAAAAAPAALSALEQEVLELVNAYRAAAGLPPLTWDPRLTAAARAHAQDMAENGYFSHTGPDgsspfdrlkaagysyra 86

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2113642615 453 HGENLWYkwnssvRDASGSEVVDTWYNeikdynfskpgfqsNTGHFTQVVWKDSREVGIAKAVDGKGMVIAVAQY 527
Cdd:COG2340    87 AGENIAA------GYSTAEEAVDGWMN--------------SPGHRANILNPDFTEIGVGVAYGGDGGVYWTQVF 141

Cysteine-rich secretory protein family; This is a large family of cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins (CAP) that are found in a wide range of organizms, including prokaryotes and non-vertebrate eukaryotes, The nine subfamilies of the mammalian CAP 'super'family include: the human glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), cysteine-rich secretory proteins (CRISPs), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), mannose receptor like and the R3H domain containing like proteins. Members are most often secreted and have an extracellular endocrine or paracrine function and are involved in processes including the regulation of extracellular matrix and branching morphogenesis, potentially as either proteases or protease inhibitors; in ion channel regulation in fertility; as tumour suppressor or pro-oncogenic genes in tissues including the prostate; and in cell-cell adhesion during fertilization. The overall protein structural conservation within the CAP 'super'family results in fundamentally similar functions for the CAP domain in all members, yet the diversity outside of this core region dramatically alters the target specificity and, thus, the biological consequences. The Ca++-chelating function would fit with the various signalling processes (e.g. the CRISP proteins) that members of this family are involved in, and also the sequence and structural evidence of a conserved pocket containing two histidines and a glutamate. It also may explain how Swiss:Q91055 blocks the Ca++ transporting ryanodine receptors.

Pssm-ID: 395136 Cd Length: 117 Bit Score: 70.69 E-value: 1.35e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615 769 LNEHNKYRRVHGSGALQLTTPLTQEAQKWADHLVGvRALQNSSTEHGENLW------YRWGTDTSLPTGKEVAESWYNEI 842
Cdd:pfam00188   1 LDLHNEYRAAAGLPPLSWDNELAAAAQDHAKYCAD-NGSHNHRSPYGGNIYarvvaaGYALGDAGPDSAEDAVDGWYDSP 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2113642615 843 SKYNFstpgfqsgsGNFTQMVWKGSTQVGFGLSTDNKGMYI 883
Cdd:pfam00188  80 GTYNC---------GHRTNLLWPKSTKVGCAVAKCGDGGTY 111

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of cysteine-rich secretory proteins; Cysteine-rich secretory proteins (CRISPs) are two-domain proteins with an evolutionary diverse and structurally conserved N-terminal CAP domain and a C-terminal cysteine-rich domain, which is comprised of a hinge and an ICR (ion channel regulator) region. CRISPs are involved in response to pathogens, fertilization, and sperm maturation. One member, Tex31 from the venom duct of Conus textile, has been shown to possess proteolytic activity sensitive to serine protease inhibitors. CRISP-1 has been shown to mediate gamete fusion by binding to the egg surface. Other members of the CRISP family secreted in the testis (CRISP2), epididymis (CRISP3-4), or during ejaculation (CRISP3), are also involved in sperm-egg interaction, supporting the existence of a functional redundancy and cooperation between homolog proteins ensuring the success of fertilization. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1) and allergen 5 from vespid venom, among others.

Pssm-ID: 349402 Cd Length: 139 Bit Score: 71.23 E-value: 1.67e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615 405 QEALDTHNKYRRLHGAPP---LQL--SRELCESSQKWANHLL----SINALQHSNTNHGENLWykwNSSvRDASGSEVVD 475
Cdd:cd05383     4 QEIVDLHNALRRSVNPPAsnmLKMswNPEAAENAQRWANRCNfthsPPNGRTIPGIRCGENIF---MSS-YPASWSEVIQ 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2113642615 476 TWYNEIKDYNF---SKPGfQSNTGHFTQVVWKDSREVGIAKAV---DGKGMVIAVAQYSPA 530
Cdd:cd05383    80 AWYDEYKDFKYgvgAKPP-GSVTGHYTQVVWYSSYLVGCAVAYcpsQGSLKYFYVCQYCPA 139

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain family; The CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain, also called SCP (sperm-coating glycoprotein), is found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in cell wall loosening. This family also includes CRISPs (cysteine-rich secretory proteins), which combine the CAP/SCP domain with a C-terminal cysteine rich domain, and allergen 5 from vespid venom. Roles for CRISP, in response to pathogens, fertilization, and sperm maturation have been proposed. One member, Tex31 from the venom duct of Conus textile, has been shown to possess proteolytic activity sensitive to serine protease inhibitors. The human GAPR-1 protein has been reported to dimerize, and such a dimer may form an active site containing a catalytic triad. CAP/SCP has also been proposed to be a Ca++ chelating serine protease. The Ca++-chelating function would fit with various signaling processes that members of this family, such as the CRISPs, are involved in, and is supported by sequence and structural evidence of a conserved pocket containing two histidines and a glutamate. It also may explain how helothermine, a toxic peptide secreted by the beaded lizard, blocks Ca++ transporting ryanodine receptors. Little is known about the biological roles of the bacterial and archaeal CAP/SCP domains.

Pssm-ID: 349397 Cd Length: 128 Bit Score: 70.73 E-value: 2.01e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615 768 LLNEHNKYRRVHGSGA-----LQLTTPLTQEAQKWADHLVGVRALQNSSTEHGENLWyrWGTDTSlpTGKEVAESWYNEI 842
Cdd:cd00168     4 ILDLHNSYRSSVSPPAsnmplMAWDQELADVAIGYAKDCIFSHSSPTSRQLAGENIA--ASSYDM--DGVAALQAWHNEI 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2113642615 843 SKYNFST--PGFQSGSGNFTQMVWKGSTQVGFGLSTDNKGMYISVGFY 888
Cdd:cd00168    80 KNYNFGTaqPGFNSGTGHYTQMVWEKTTKLGCGVADCSDNSKFVVCNY 127

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of cysteine-rich secretory proteins; Cysteine-rich secretory proteins (CRISPs) are two-domain proteins with an evolutionary diverse and structurally conserved N-terminal CAP domain and a C-terminal cysteine-rich domain, which is comprised of a hinge and an ICR (ion channel regulator) region. CRISPs are involved in response to pathogens, fertilization, and sperm maturation. One member, Tex31 from the venom duct of Conus textile, has been shown to possess proteolytic activity sensitive to serine protease inhibitors. CRISP-1 has been shown to mediate gamete fusion by binding to the egg surface. Other members of the CRISP family secreted in the testis (CRISP2), epididymis (CRISP3-4), or during ejaculation (CRISP3), are also involved in sperm-egg interaction, supporting the existence of a functional redundancy and cooperation between homolog proteins ensuring the success of fertilization. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1) and allergen 5 from vespid venom, among others.

Pssm-ID: 349402 Cd Length: 139 Bit Score: 70.85 E-value: 2.65e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615 217 VSAHNIYRKKHGAPP---LQL--NRDLCRSAQAWADHLlsiqTLKHS--------GTDHGENLYYkyssSTRELPGQEPV 283
Cdd:cd05383     7 VDLHNALRRSVNPPAsnmLKMswNPEAAENAQRWANRC----NFTHSppngrtipGIRCGENIFM----SSYPASWSEVI 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2113642615 284 ESWYDEIKNYDFG----RPGfrSNTGHFTQVVWKDSKEVGVGIA---TDGNGLFFVVGQYNPA 339
Cdd:cd05383    79 QAWYDEYKDFKYGvgakPPG--SVTGHYTQVVWYSSYLVGCAVAycpSQGSLKYFYVCQYCPA 139

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of glioma pathogenesis-related protein 1 and similar proteins; Glioma pathogenesis-related protein 1 (GLIPR1) is also called related to testes-specific, vespid, and pathogenesis protein 1 (RTVP-1). The GLIPR1 gene has been identified as a p53 target gene and was shown to be methylated and down-regulated in prostate cancer. It is a novel broad-spectrum tumor suppressor whose proapoptotic properties are exerted in part through ROS-JNK signaling. GLIPR1 is composed of a signal peptide that directs its secretion, a CAP domain, and a transmembrane domain. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.

Pssm-ID: 349404 Cd Length: 148 Bit Score: 70.13 E-value: 4.67e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615 212 FEKDFVSAHNIYRKKHGAPPLQLN-----RDLCRSAQAWADHLLSIQT--LKHSGTDH------GENLYykySSSTRELP 278
Cdd:cd05385     2 FIDECVRIHNELRSKVSPPAANMRymswdKALAKTARAWARKCKFSHNicLKEPGKCHpnfttlGENIW---LGSIFSFS 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2113642615 279 GQEPVESWYDEIKNYDFGrpgfrSNT-----GHFTQVVWKDSKEVGVGIATDGNGLFFVVG--------QYNPAG 340
Cdd:cd05385    79 VESAITSWYNEVKDYNFK-----TNScsrvcGHYTQVVWADSYKVGCAVHVCPNGGGFFSGsssaifvcNYGPAG 148

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of cysteine-rich secretory proteins; Cysteine-rich secretory proteins (CRISPs) are two-domain proteins with an evolutionary diverse and structurally conserved N-terminal CAP domain and a C-terminal cysteine-rich domain, which is comprised of a hinge and an ICR (ion channel regulator) region. CRISPs are involved in response to pathogens, fertilization, and sperm maturation. One member, Tex31 from the venom duct of Conus textile, has been shown to possess proteolytic activity sensitive to serine protease inhibitors. CRISP-1 has been shown to mediate gamete fusion by binding to the egg surface. Other members of the CRISP family secreted in the testis (CRISP2), epididymis (CRISP3-4), or during ejaculation (CRISP3), are also involved in sperm-egg interaction, supporting the existence of a functional redundancy and cooperation between homolog proteins ensuring the success of fertilization. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1) and allergen 5 from vespid venom, among others.

Pssm-ID: 349402 Cd Length: 139 Bit Score: 66.61 E-value: 7.52e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615  24 QDFLDAHNKYRAlHGSPP----LQL--NTDLCESSQKWADHLlsirTVRHSDTEY--------GENI---DYKSSSSpkv 86
Cdd:cd05383     4 QEIVDLHNALRR-SVNPPasnmLKMswNPEAAENAQRWANRC----NFTHSPPNGrtipgircGENIfmsSYPASWS--- 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2113642615  87 lagnAPVDSWYSEIKNYDF---SKPGFSVsTGHFTQVVWKESKEVGFGVA---TDSKKAYYVVAQYNPS 149
Cdd:cd05383    76 ----EVIQAWYDEYKDFKYgvgAKPPGSV-TGHYTQVVWYSSYLVGCAVAycpSQGSLKYFYVCQYCPA 139

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of glioma pathogenesis-related protein 1 and similar proteins; Glioma pathogenesis-related protein 1 (GLIPR1) is also called related to testes-specific, vespid, and pathogenesis protein 1 (RTVP-1). The GLIPR1 gene has been identified as a p53 target gene and was shown to be methylated and down-regulated in prostate cancer. It is a novel broad-spectrum tumor suppressor whose proapoptotic properties are exerted in part through ROS-JNK signaling. GLIPR1 is composed of a signal peptide that directs its secretion, a CAP domain, and a transmembrane domain. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.

Pssm-ID: 349404 Cd Length: 148 Bit Score: 65.89 E-value: 1.64e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615 586 AFAKEFLKANNAYRSQ---HGAKPLQLS--TRISQDAQKWAEHLLtlktLKHSD------------TSCGENIWakTGSP 648
Cdd:cd05385     1 AFIDECVRIHNELRSKvspPAANMRYMSwdKALAKTARAWARKCK----FSHNIclkepgkchpnfTTLGENIW--LGSI 74

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2113642615 649 SItVTGQEVADSWYKEEKNYNFFKPGHQPDTGHFTQMVWKASKEVG--VGIASSGKGMF------IVVAQYHPCG 715
Cdd:cd05385    75 FS-FSVESAITSWYNEVKDYNFKTNSCSRVCGHYTQVVWADSYKVGcaVHVCPNGGGFFsgsssaIFVCNYGPAG 148

Bacterial CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins; Little is known about bacterial and archaeal members of the CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain family. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others. Studies of eukaryotic proteins show that CAP domains have several functions, including the binding of cholesterol, lipids and heparan sulfate. This group includes Borrelia burgdorferi outer surface protein BB0689, which does not bind to cholesterol, lipids, or heparan sulfate, and whose function is unknown.

Pssm-ID: 349398 Cd Length: 120 Bit Score: 63.55 E-value: 5.96e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615 213 EKDFVSAHNIYRKKHGAPPLQLNRDLCRSAQAWADHLLSIQTLKHSGTDH---------------GENLYYKYSSstrel 277
Cdd:cd05379     1 EQEVLELINEYRAKAGLPPLSWDPRLEKAAQDHAEDMAANGYFSHTGPDGssdraaragywyrgaGENIAYGQGS----- 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2113642615 278 pGQEPVESWYDEiknydfgrPGFRSNtghftqVVWKDSKEVGVGIATDGNGLFFVVGQY 336
Cdd:cd05379    76 -AEEAVNQWINS--------PGHRAN------ILDPDFTEIGVGVAYNSSGGTYWTQVF 119

Bacterial CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins; Little is known about bacterial and archaeal members of the CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain family. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others. Studies of eukaryotic proteins show that CAP domains have several functions, including the binding of cholesterol, lipids and heparan sulfate. This group includes Borrelia burgdorferi outer surface protein BB0689, which does not bind to cholesterol, lipids, or heparan sulfate, and whose function is unknown.

Pssm-ID: 349398 Cd Length: 120 Bit Score: 62.40 E-value: 1.40e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615  23 EQDFLDAHNKYRALHGSPPLQLNTDLCESSQKWADHLLSIRTVRHSDTEY---------------GENIDYKSSSSPKVl 87
Cdd:cd05379     1 EQEVLELINEYRAKAGLPPLSWDPRLEKAAQDHAEDMAANGYFSHTGPDGssdraaragywyrgaGENIAYGQGSAEEA- 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2113642615  88 agnapVDSWYSeiknydfskpgfsvSTGHFTQVVWKESKEVGFGVATDSKKAYYVVAQY 146
Cdd:cd05379    80 -----VNQWIN--------------SPGHRANILDPDFTEIGVGVAYNSSGGTYWTQVF 119

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of cysteine-rich secretory proteins; Cysteine-rich secretory proteins (CRISPs) are two-domain proteins with an evolutionary diverse and structurally conserved N-terminal CAP domain and a C-terminal cysteine-rich domain, which is comprised of a hinge and an ICR (ion channel regulator) region. CRISPs are involved in response to pathogens, fertilization, and sperm maturation. One member, Tex31 from the venom duct of Conus textile, has been shown to possess proteolytic activity sensitive to serine protease inhibitors. CRISP-1 has been shown to mediate gamete fusion by binding to the egg surface. Other members of the CRISP family secreted in the testis (CRISP2), epididymis (CRISP3-4), or during ejaculation (CRISP3), are also involved in sperm-egg interaction, supporting the existence of a functional redundancy and cooperation between homolog proteins ensuring the success of fertilization. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1) and allergen 5 from vespid venom, among others.

Pssm-ID: 349402 Cd Length: 139 Bit Score: 62.76 E-value: 1.55e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615 615 QDAQKWAEHLltlkTLKHSD--------TSCGENIWAKTGSPSITvtgqEVADSWYKEEKNYNFFKPGHQPD--TGHFTQ 684
Cdd:cd05383    35 ENAQRWANRC----NFTHSPpngrtipgIRCGENIFMSSYPASWS----EVIQAWYDEYKDFKYGVGAKPPGsvTGHYTQ 106

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2113642615 685 MVWKASKEVGVGIA---SSGKGMFIVVAQYHP 713
Cdd:cd05383   107 VVWYSSYLVGCAVAycpSQGSLKYFYVCQYCP 138

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of glioma pathogenesis-related protein 1 and similar proteins; Glioma pathogenesis-related protein 1 (GLIPR1) is also called related to testes-specific, vespid, and pathogenesis protein 1 (RTVP-1). The GLIPR1 gene has been identified as a p53 target gene and was shown to be methylated and down-regulated in prostate cancer. It is a novel broad-spectrum tumor suppressor whose proapoptotic properties are exerted in part through ROS-JNK signaling. GLIPR1 is composed of a signal peptide that directs its secretion, a CAP domain, and a transmembrane domain. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.

Pssm-ID: 349404 Cd Length: 148 Bit Score: 57.42 E-value: 1.63e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615 764 FRKDLLNEHNKYR-RVH--GSGALQLT--TPLTQEAQKWADHLVGVR--ALQNSSTEH------GENLWYrwGTDTSLpT 830
Cdd:cd05385     2 FIDECVRIHNELRsKVSppAANMRYMSwdKALAKTARAWARKCKFSHniCLKEPGKCHpnfttlGENIWL--GSIFSF-S 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615 831 GKEVAESWYNEISKYNFSTPGFQSGSGNFTQMVWKGSTQVGFGLSTDNKGMYISVGF--------YDPAG 892
Cdd:cd05385    79 VESAITSWYNEVKDYNFKTNSCSRVCGHYTQVVWADSYKVGCAVHVCPNGGGFFSGSssaifvcnYGPAG 148

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of glioma pathogenesis-related protein 1 and similar proteins; Glioma pathogenesis-related protein 1 (GLIPR1) is also called related to testes-specific, vespid, and pathogenesis protein 1 (RTVP-1). The GLIPR1 gene has been identified as a p53 target gene and was shown to be methylated and down-regulated in prostate cancer. It is a novel broad-spectrum tumor suppressor whose proapoptotic properties are exerted in part through ROS-JNK signaling. GLIPR1 is composed of a signal peptide that directs its secretion, a CAP domain, and a transmembrane domain. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.

Pssm-ID: 349404 Cd Length: 148 Bit Score: 56.26 E-value: 3.79e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615  22 FEQDFLDAHNKYRAlHGSPP----LQLNTD--LCESSQKWA-----DHLLSIRTVR--HSDTEY-GENIdykSSSSPKVL 87
Cdd:cd05385     2 FIDECVRIHNELRS-KVSPPaanmRYMSWDkaLAKTARAWArkckfSHNICLKEPGkcHPNFTTlGENI---WLGSIFSF 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2113642615  88 AGNAPVDSWYSEIKNYDFSKPGFSVSTGHFTQVVWKESKEVGFGVATDSKKAYYV--------VAQYNPSG 150
Cdd:cd05385    78 SVESAITSWYNEVKDYNFKTNSCSRVCGHYTQVVWADSYKVGCAVHVCPNGGGFFsgsssaifVCNYGPAG 148

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of peptidase inhibitor 16 and HrTT-1 protein; Human peptidase inhibitor 16 (PI16) is also called cysteine-rich secretory protein 9 (CRISP-9) or PSP94-binding protein. Mouse PI16 is also called cysteine-rich protease inhibitor. PI16 is predominantly expressed by cardiac fibroblasts and is exposed to the interstitium via a glycophosphatidylinositol (-GPI) membrane anchor. It suppresses the activation of the chemokine chemerin in the myocardium, which may be a part of the cardiac stress response. At high endothelial shear stress, PI16 is an inflammation-regulated inhibitor of matrix metalloproteinase 2 (MMP2). Also included in this subfamily is the HrTT-1 protein, a tail-tip epidermis marker in ascidians. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.

Pssm-ID: 349405 Cd Length: 134 Bit Score: 55.12 E-value: 6.69e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615 765 RKDLLNEHNKYRRVHGSGA---LQLT--TPLTQEAQKWA-----DHlvgvralqNSSTEH-GENLWYrwGTDTSLPTGKE 833
Cdd:cd05559     1 KKLLVDLHNQYRSQVSPSAanmLKMTwdTELEALAKAYArkciwEH--------NPDRGRvGENLFA--STGKPLDVELA 70

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2113642615 834 VaESWYNEISKYNFSTPGFQSGS--GNFTQMVWKGSTQVGFG 873
Cdd:cd05559    71 V-EDWHNEKEYYNFETKTCAPGKmcGHYTQVVWANTEKIGCG 111

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of peptidase inhibitor 16 and HrTT-1 protein; Human peptidase inhibitor 16 (PI16) is also called cysteine-rich secretory protein 9 (CRISP-9) or PSP94-binding protein. Mouse PI16 is also called cysteine-rich protease inhibitor. PI16 is predominantly expressed by cardiac fibroblasts and is exposed to the interstitium via a glycophosphatidylinositol (-GPI) membrane anchor. It suppresses the activation of the chemokine chemerin in the myocardium, which may be a part of the cardiac stress response. At high endothelial shear stress, PI16 is an inflammation-regulated inhibitor of matrix metalloproteinase 2 (MMP2). Also included in this subfamily is the HrTT-1 protein, a tail-tip epidermis marker in ascidians. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.

Pssm-ID: 349405 Cd Length: 134 Bit Score: 52.81 E-value: 3.66e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615 589 KEFLKANNAYRSQHGAKP---LQLS--TRISQDAQKWAEHLLtlktLKHS-DTS-CGENIWAKTGSPSitvTGQEVADSW 661
Cdd:cd05559     2 KLLVDLHNQYRSQVSPSAanmLKMTwdTELEALAKAYARKCI----WEHNpDRGrVGENLFASTGKPL---DVELAVEDW 74

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2113642615 662 YKEEKNYNFFKPGHQPDT--GHFTQMVWKASKEVGVG 696
Cdd:cd05559    75 HNEKEYYNFETKTCAPGKmcGHYTQVVWANTEKIGCG 111

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of peptidase inhibitor 16 and HrTT-1 protein; Human peptidase inhibitor 16 (PI16) is also called cysteine-rich secretory protein 9 (CRISP-9) or PSP94-binding protein. Mouse PI16 is also called cysteine-rich protease inhibitor. PI16 is predominantly expressed by cardiac fibroblasts and is exposed to the interstitium via a glycophosphatidylinositol (-GPI) membrane anchor. It suppresses the activation of the chemokine chemerin in the myocardium, which may be a part of the cardiac stress response. At high endothelial shear stress, PI16 is an inflammation-regulated inhibitor of matrix metalloproteinase 2 (MMP2). Also included in this subfamily is the HrTT-1 protein, a tail-tip epidermis marker in ascidians. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.

Pssm-ID: 349405 Cd Length: 134 Bit Score: 51.26 E-value: 1.40e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615 408 LDTHNKYRRLHGAPP---LQLSrelcessqkWANHLLSINA-------LQHS--NTNHGENLWYkwnSSVRDASGSEVVD 475
Cdd:cd05559     5 VDLHNQYRSQVSPSAanmLKMT---------WDTELEALAKayarkciWEHNpdRGRVGENLFA---STGKPLDVELAVE 72

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2113642615 476 TWYNEIKDYNFSKPGFQSNT--GHFTQVVWKDSREVGIAKA-------VDGKGMVIAVAQYS 528
Cdd:cd05559    73 DWHNEKEYYNFETKTCAPGKmcGHYTQVVWANTEKIGCGSYfcetlegVEWENATLLVCNYE 134

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of peptidase inhibitor 16 and HrTT-1 protein; Human peptidase inhibitor 16 (PI16) is also called cysteine-rich secretory protein 9 (CRISP-9) or PSP94-binding protein. Mouse PI16 is also called cysteine-rich protease inhibitor. PI16 is predominantly expressed by cardiac fibroblasts and is exposed to the interstitium via a glycophosphatidylinositol (-GPI) membrane anchor. It suppresses the activation of the chemokine chemerin in the myocardium, which may be a part of the cardiac stress response. At high endothelial shear stress, PI16 is an inflammation-regulated inhibitor of matrix metalloproteinase 2 (MMP2). Also included in this subfamily is the HrTT-1 protein, a tail-tip epidermis marker in ascidians. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.

Pssm-ID: 349405 Cd Length: 134 Bit Score: 50.49 E-value: 2.54e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615  27 LDAHNKYRAlHGSPP----LQLNTD-----LCES-SQK--WaDHllsirtvrHSDTEY-GENIdykSSSSPKVLAGNAPV 93
Cdd:cd05559     5 VDLHNQYRS-QVSPSaanmLKMTWDteleaLAKAyARKciW-EH--------NPDRGRvGENL---FASTGKPLDVELAV 71

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2113642615  94 DSWYSEIKNYDFSKPGFSVST--GHFTQVVWKESKEVGFGVAT-------DSKKAYYVVAQY 146
Cdd:cd05559    72 EDWHNEKEYYNFETKTCAPGKmcGHYTQVVWANTEKIGCGSYFcetlegvEWENATLLVCNY 133

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of peptidase inhibitor 16 and HrTT-1 protein; Human peptidase inhibitor 16 (PI16) is also called cysteine-rich secretory protein 9 (CRISP-9) or PSP94-binding protein. Mouse PI16 is also called cysteine-rich protease inhibitor. PI16 is predominantly expressed by cardiac fibroblasts and is exposed to the interstitium via a glycophosphatidylinositol (-GPI) membrane anchor. It suppresses the activation of the chemokine chemerin in the myocardium, which may be a part of the cardiac stress response. At high endothelial shear stress, PI16 is an inflammation-regulated inhibitor of matrix metalloproteinase 2 (MMP2). Also included in this subfamily is the HrTT-1 protein, a tail-tip epidermis marker in ascidians. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.

Pssm-ID: 349405 Cd Length: 134 Bit Score: 50.49 E-value: 2.57e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615 217 VSAHNIYRKKHGAPP---LQLNRD--LCRSAQAWA-----DHLlsiqtlKHSGTdHGENLYykySSSTRELPGQEPVESW 286
Cdd:cd05559     5 VDLHNQYRSQVSPSAanmLKMTWDteLEALAKAYArkciwEHN------PDRGR-VGENLF---ASTGKPLDVELAVEDW 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2113642615 287 YDEIKNYDFGRPGFRSNT--GHFTQVVWKDSKEVGVGIAT 324
Cdd:cd05559    75 HNEKEYYNFETKTCAPGKmcGHYTQVVWANTEKIGCGSYF 114

Bacterial CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins; Little is known about bacterial and archaeal members of the CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain family. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others. Studies of eukaryotic proteins show that CAP domains have several functions, including the binding of cholesterol, lipids and heparan sulfate. This group includes Borrelia burgdorferi outer surface protein BB0689, which does not bind to cholesterol, lipids, or heparan sulfate, and whose function is unknown.

Pssm-ID: 349398 Cd Length: 120 Bit Score: 50.07 E-value: 2.90e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615 588 AKEFLKANNAYRSQHGAKPLQLSTRISQDAQKWAEHLLTLKTLKHSDTSCGENIWAKTGSPSITV---------TGQEVA 658
Cdd:cd05379     1 EQEVLELINEYRAKAGLPPLSWDPRLEKAAQDHAEDMAANGYFSHTGPDGSSDRAARAGYWYRGAgeniaygqgSAEEAV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2113642615 659 DSWYKeeknynffkpghqpDTGHFTQMVWKASKEVGVGIASSGKGMFIVVAQY 711
Cdd:cd05379    81 NQWIN--------------SPGHRANILDPDFTEIGVGVAYNSSGGTYWTQVF 119

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of cysteine-rich secretory protein LCCL domain-containing 1; Cysteine-rich secretory protein LCCL domain-containing 1 (CRISPLD1) is also called cysteine-rich secretory protein 10 (CRISP-10), CocoaCrisp, LCCL domain-containing cysteine-rich secretory protein 1 (LCRISP1), or CAP and LCCL domain containing protein 1 (CAPLD1). CRISPLD1 is clearly distinct from CRISPs because they do not contain the 10 absolutely conserved cysteines or the ICR (ion channel regulator) domain of the CRISPs. It may play a role in NSCLP (nonsyndromic cleft lip with or without cleft palate) through the interaction with CRISPLD2 and folate pathway genes. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.

Pssm-ID: 349407 Cd Length: 146 Bit Score: 50.77 E-value: 3.08e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615 405 QEALDTHNKYRRlHGAPP------LQLSRELCESSQKWANHLLSINALQHSNTNHGENLWYKWNssvRDASGSEVVDTWY 478
Cdd:cd18813     2 QLILDLHNKLRG-QVYPPasnmeyMTWDVELERSAEAWAETCLWEHGPAHLLPSIGQNLGAHWG---RYRPPTFHVQAWY 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2113642615 479 NEIKDYNFSKPGfQSN-------TG----HFTQVVWKDSREVGIA 512
Cdd:cd18813    78 DEVRDFSYPYPQ-ECNpycpfrcSGpvctHYTQVVWATSNRIGCA 121

Bacterial CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins; Little is known about bacterial and archaeal members of the CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain family. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others. Studies of eukaryotic proteins show that CAP domains have several functions, including the binding of cholesterol, lipids and heparan sulfate. This group includes Borrelia burgdorferi outer surface protein BB0689, which does not bind to cholesterol, lipids, or heparan sulfate, and whose function is unknown.

Pssm-ID: 349398 Cd Length: 120 Bit Score: 48.92 E-value: 6.23e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615 404 EQEALDTHNKYRRLHGAPPLQLSRELCESSQKWANHLLSINALQHSNTNHGENLWYKWNSSVRDA---------SGSEVV 474
Cdd:cd05379     1 EQEVLELINEYRAKAGLPPLSWDPRLEKAAQDHAEDMAANGYFSHTGPDGSSDRAARAGYWYRGAgeniaygqgSAEEAV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2113642615 475 DTWYNEIkdynfskpgfqsntGHFTQVVWKDSREVGIAKAVDGKGMVIAVAQY 527
Cdd:cd05379    81 NQWINSP--------------GHRANILDPDFTEIGVGVAYNSSGGTYWTQVF 119

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of cysteine-rich secretory protein LCCL domain-containing 1; Cysteine-rich secretory protein LCCL domain-containing 1 (CRISPLD1) is also called cysteine-rich secretory protein 10 (CRISP-10), CocoaCrisp, LCCL domain-containing cysteine-rich secretory protein 1 (LCRISP1), or CAP and LCCL domain containing protein 1 (CAPLD1). CRISPLD1 is clearly distinct from CRISPs because they do not contain the 10 absolutely conserved cysteines or the ICR (ion channel regulator) domain of the CRISPs. It may play a role in NSCLP (nonsyndromic cleft lip with or without cleft palate) through the interaction with CRISPLD2 and folate pathway genes. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.

Pssm-ID: 349407 Cd Length: 146 Bit Score: 49.62 E-value: 6.58e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615 237 DLCRSAQAWADHLLSIQTLKHSGTDHGENLYYKYSsstRELPGQEPVESWYDEIKNYDFGRPG-------FRSN---TGH 306
Cdd:cd18813    30 ELERSAEAWAETCLWEHGPAHLLPSIGQNLGAHWG---RYRPPTFHVQAWYDEVRDFSYPYPQecnpycpFRCSgpvCTH 106

                          90
                  ....*....|....*.
gi 2113642615 307 FTQVVWKDSKEVGVGI 322
Cdd:cd18813   107 YTQVVWATSNRIGCAI 122

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of cysteine-rich secretory protein LCCL domain-containing 2; Cysteine-rich secretory protein LCCL domain-containing 2 (CRISPLD2) is also called cysteine-rich secretory protein 11 (CRSIP-11), LCCL domain-containing cysteine-rich secretory protein 2 (LCRISP2), or CAP and LCCL domain containing protein 2 (CAPLD2). It plays a role in the etiology of NSCLP (non-syndromic cleft lip with or without cleft palate). It is required for neural crest cell migration and cell viability during craniofacial development. The CRISPLD2 gene has been identified a glucocorticoid responsive gene that modulates cytokine function in airway smooth muscle cells. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.

Pssm-ID: 349410 Cd Length: 146 Bit Score: 45.74 E-value: 1.36e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615 404 EQEALDTHNKYR-RLHGAPP----LQLSRELCESSQKWANHLLSINALQHSNTNHGENLWYKWNssvRDASGSEVVDTWY 478
Cdd:cd18816     1 KEEILQLHNKLRgQVYPSASnmeyMTWDDELERSAEAWAQQCIWEHGPTSLLPSIGQNLAVHWG---RYRSPAFHVQSWY 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2113642615 479 NEIKDYNFSKPgFQSN-------TG----HFTQVVWKDSREVGIA 512
Cdd:cd18816    78 DEVKDYTYPYP-HECNpwcpercSGpmctHYTQIVWATTNKVGCA 121

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of peptidase inhibitor 15 and similar proteins; This family is composed of peptidase inhibitor 15 (PI15), peptidase inhibitor R3HDML, cysteine-rich secretory protein LCCL domain-containing 1 (CRISPLD1), and cysteine-rich secretory protein LCCL domain-containing 2 (CRISPLD2). PI15 is a serine protease inhibitor which displays weak inhibitory activity against trypsin and may play a role in facial patterning during embryonic development. The PI15 gene is a candidate gene for abdominal aortic internal elastic lamina ruptures in the rat. R3HDML is a putative serine protease inhibitor, whose gene may be associated with clinical dimensions of schizophrenia. CRISPLD1 may play a role in NSCLP (nonsyndromic cleft lip with or without cleft palate) through the interaction with CRISPLD2 and folate pathway genes. plays a role in the etiology of NSCLP and is required for neural crest cell migration and cell viability during craniofacial development. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.

Pssm-ID: 349406 Cd Length: 146 Bit Score: 44.12 E-value: 5.38e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615 405 QEALDTHNKYRRLHGAPPLQLS-----RELCESSQKWANHLLSINALQHSNTNHGENLWYKWNssvRDASGSEVVDTWYN 479
Cdd:cd18812     2 NAILDYHNKLRGQVYPPAANMEymvwdKELARSAEAWATQCIWEHGPSSLLRSIGQNLSAHWG---RYRSPVFLVKSWYD 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2113642615 480 EIKDYNFSKPG----------FQSNTGHFTQVVWKDSREVGIA 512
Cdd:cd18812    79 EVKDYLFPYPRdcnphcpwrcSGPMCTHYTQMVWATSNRIGCA 121

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of peptidase inhibitor 15; Peptidase inhibitor 15 (PI15) is also called 25 kDa trypsin inhibitor (p25TI), cysteine-rich secretory protein 8 (CRISP-8), or SugarCrisp. It is a serine protease inhibitor which displays weak inhibitory activity against trypsin and may play a role in facial patterning during embryonic development. The PI15 gene is a candidate gene for abdominal aortic internal elastic lamina ruptures in the rat. PI15 may also participate in the regulation of drug resistance in ovarian cancer and serve as a potential target in targeted therapies. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.

Pssm-ID: 349408 Cd Length: 146 Bit Score: 43.45 E-value: 9.10e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615  27 LDAHNKYRALHGSPPLQL-----NTDLCESSQKWADHLLSIRTVRHSDTEYGENIDYKSSSSPKVLAGNAPvdsWYSEIK 101
Cdd:cd18814     5 LDYHNQVRGKVFPPAANMeymvwDENLAKSAEAWAATCIWDHGPSYLLRFLGQNLSVRTGRYRSILQLVKP---WYDEVK 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2113642615 102 NYDFSKPG----------FSVSTGHFTQVVWKESKEVGFGVATDS---------KKAYYVVAQY 146
Cdd:cd18814    82 DYAFPYPQdcnprcplrcYGPMCTHYTQMVWATSNRIGCAIHTCHnmnvwgsvwRRAVYLVCNY 145

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of peptidase inhibitor 15; Peptidase inhibitor 15 (PI15) is also called 25 kDa trypsin inhibitor (p25TI), cysteine-rich secretory protein 8 (CRISP-8), or SugarCrisp. It is a serine protease inhibitor which displays weak inhibitory activity against trypsin and may play a role in facial patterning during embryonic development. The PI15 gene is a candidate gene for abdominal aortic internal elastic lamina ruptures in the rat. PI15 may also participate in the regulation of drug resistance in ovarian cancer and serve as a potential target in targeted therapies. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.

Pssm-ID: 349408 Cd Length: 146 Bit Score: 43.07 E-value: 1.22e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615 408 LDTHNKYRRLHGAPPLQLS-----RELCESSQKWANHLLsinalqhsnTNHGENLWYKW---NSSVRDA---SGSEVVDT 476
Cdd:cd18814     5 LDYHNQVRGKVFPPAANMEymvwdENLAKSAEAWAATCI---------WDHGPSYLLRFlgqNLSVRTGryrSILQLVKP 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2113642615 477 WYNEIKDYNFSKPG----------FQSNTGHFTQVVWKDSREVGIA 512
Cdd:cd18814    76 WYDEVKDYAFPYPQdcnprcplrcYGPMCTHYTQMVWATSNRIGCA 121

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of peptidase inhibitor 15 and similar proteins; This family is composed of peptidase inhibitor 15 (PI15), peptidase inhibitor R3HDML, cysteine-rich secretory protein LCCL domain-containing 1 (CRISPLD1), and cysteine-rich secretory protein LCCL domain-containing 2 (CRISPLD2). PI15 is a serine protease inhibitor which displays weak inhibitory activity against trypsin and may play a role in facial patterning during embryonic development. The PI15 gene is a candidate gene for abdominal aortic internal elastic lamina ruptures in the rat. R3HDML is a putative serine protease inhibitor, whose gene may be associated with clinical dimensions of schizophrenia. CRISPLD1 may play a role in NSCLP (nonsyndromic cleft lip with or without cleft palate) through the interaction with CRISPLD2 and folate pathway genes. plays a role in the etiology of NSCLP and is required for neural crest cell migration and cell viability during craniofacial development. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.

Pssm-ID: 349406 Cd Length: 146 Bit Score: 42.58 E-value: 1.90e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615 235 NRDLCRSAQAWADHLLsiqtlkhsgTDHGENLYYKY------SSSTRELPGQEPVESWYDEIKNYDFGRPG-------FR 301
Cdd:cd18812    28 DKELARSAEAWATQCI---------WEHGPSSLLRSigqnlsAHWGRYRSPVFLVKSWYDEVKDYLFPYPRdcnphcpWR 98

                          90       100
                  ....*....|....*....|....*.
gi 2113642615 302 SN---TGHFTQVVWKDSKEVGVGIAT 324
Cdd:cd18812    99 CSgpmCTHYTQMVWATSNRIGCAIHT 124

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of peptidase inhibitor 15; Peptidase inhibitor 15 (PI15) is also called 25 kDa trypsin inhibitor (p25TI), cysteine-rich secretory protein 8 (CRISP-8), or SugarCrisp. It is a serine protease inhibitor which displays weak inhibitory activity against trypsin and may play a role in facial patterning during embryonic development. The PI15 gene is a candidate gene for abdominal aortic internal elastic lamina ruptures in the rat. PI15 may also participate in the regulation of drug resistance in ovarian cancer and serve as a potential target in targeted therapies. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.

Pssm-ID: 349408 Cd Length: 146 Bit Score: 42.68 E-value: 2.01e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615 220 HNIYRKKHGAPPLQL-----NRDLCRSAQAWADHLLsiqtlkhsgTDHGENLYYKY------SSSTRELPGQEPVESWYD 288
Cdd:cd18814     8 HNQVRGKVFPPAANMeymvwDENLAKSAEAWAATCI---------WDHGPSYLLRFlgqnlsVRTGRYRSILQLVKPWYD 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2113642615 289 EIKNYDFGRPG----------FRSNTGHFTQVVWKDSKEVGVGIATDGN 327
Cdd:cd18814    79 EVKDYAFPYPQdcnprcplrcYGPMCTHYTQMVWATSNRIGCAIHTCHN 127

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of cysteine-rich secretory proteins; Cysteine-rich secretory proteins (CRISPs) are two-domain proteins with an evolutionary diverse and structurally conserved N-terminal CAP domain and a C-terminal cysteine-rich domain, which is comprised of a hinge and an ICR (ion channel regulator) region. CRISPs are involved in response to pathogens, fertilization, and sperm maturation. One member, Tex31 from the venom duct of Conus textile, has been shown to possess proteolytic activity sensitive to serine protease inhibitors. CRISP-1 has been shown to mediate gamete fusion by binding to the egg surface. Other members of the CRISP family secreted in the testis (CRISP2), epididymis (CRISP3-4), or during ejaculation (CRISP3), are also involved in sperm-egg interaction, supporting the existence of a functional redundancy and cooperation between homolog proteins ensuring the success of fertilization. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1) and allergen 5 from vespid venom, among others.

Pssm-ID: 349402 Cd Length: 139 Bit Score: 42.34 E-value: 2.19e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615 765 RKDLLNEHNKYRR-VH--GSGALQL--TTPLTQEAQKWADhlvgvRALQNSS---------TEHGENLWYrwgtdTSLPT 830
Cdd:cd05383     3 QQEIVDLHNALRRsVNppASNMLKMswNPEAAENAQRWAN-----RCNFTHSppngrtipgIRCGENIFM-----SSYPA 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2113642615 831 G-KEVAESWYNEISKYNFSTPGFQSGS--GNFTQMVWKGSTQVGFGLS 875
Cdd:cd05383    73 SwSEVIQAWYDEYKDFKYGVGAKPPGSvtGHYTQVVWYSSYLVGCAVA 120

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of cysteine-rich secretory protein LCCL domain-containing 1; Cysteine-rich secretory protein LCCL domain-containing 1 (CRISPLD1) is also called cysteine-rich secretory protein 10 (CRISP-10), CocoaCrisp, LCCL domain-containing cysteine-rich secretory protein 1 (LCRISP1), or CAP and LCCL domain containing protein 1 (CAPLD1). CRISPLD1 is clearly distinct from CRISPs because they do not contain the 10 absolutely conserved cysteines or the ICR (ion channel regulator) domain of the CRISPs. It may play a role in NSCLP (nonsyndromic cleft lip with or without cleft palate) through the interaction with CRISPLD2 and folate pathway genes. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.

Pssm-ID: 349407 Cd Length: 146 Bit Score: 42.30 E-value: 2.52e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615  24 QDFLDAHNKYRAlHGSPP------LQLNTDLCESSQKWADHLLSIRTVRHSDTEYGENID-YKSSSSPKVLAgnapVDSW 96
Cdd:cd18813     2 QLILDLHNKLRG-QVYPPasnmeyMTWDVELERSAEAWAETCLWEHGPAHLLPSIGQNLGaHWGRYRPPTFH----VQAW 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615  97 YSEIKNYDFSKPG-------FSVS---TGHFTQVVWKESKEVGFGVATDSK---------KAYYVVAQYN 147
Cdd:cd18813    77 YDEVRDFSYPYPQecnpycpFRCSgpvCTHYTQVVWATSNRIGCAINLCHNmnvwgqiwpKAIYLVCNYS 146

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of cysteine-rich secretory protein LCCL domain-containing 2; Cysteine-rich secretory protein LCCL domain-containing 2 (CRISPLD2) is also called cysteine-rich secretory protein 11 (CRSIP-11), LCCL domain-containing cysteine-rich secretory protein 2 (LCRISP2), or CAP and LCCL domain containing protein 2 (CAPLD2). It plays a role in the etiology of NSCLP (non-syndromic cleft lip with or without cleft palate). It is required for neural crest cell migration and cell viability during craniofacial development. The CRISPLD2 gene has been identified a glucocorticoid responsive gene that modulates cytokine function in airway smooth muscle cells. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.

Pssm-ID: 349410 Cd Length: 146 Bit Score: 42.28 E-value: 2.76e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615 235 NRDLCRSAQAWADHLLsiqtLKHSGTDH----GENLYYKYSsstRELPGQEPVESWYDEIKNYDFGRPgFRSN------- 303
Cdd:cd18816    28 DDELERSAEAWAQQCI----WEHGPTSLlpsiGQNLAVHWG---RYRSPAFHVQSWYDEVKDYTYPYP-HECNpwcperc 99

                          90       100
                  ....*....|....*....|...
gi 2113642615 304 TG----HFTQVVWKDSKEVGVGI 322
Cdd:cd18816   100 SGpmctHYTQIVWATTNKVGCAV 122

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of cysteine-rich secretory protein LCCL domain-containing 1; Cysteine-rich secretory protein LCCL domain-containing 1 (CRISPLD1) is also called cysteine-rich secretory protein 10 (CRISP-10), CocoaCrisp, LCCL domain-containing cysteine-rich secretory protein 1 (LCRISP1), or CAP and LCCL domain containing protein 1 (CAPLD1). CRISPLD1 is clearly distinct from CRISPs because they do not contain the 10 absolutely conserved cysteines or the ICR (ion channel regulator) domain of the CRISPs. It may play a role in NSCLP (nonsyndromic cleft lip with or without cleft palate) through the interaction with CRISPLD2 and folate pathway genes. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.

Pssm-ID: 349407 Cd Length: 146 Bit Score: 41.14 E-value: 6.73e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615 611 TRISQDAQKWAEHLLTLKTLKHSDTSCGENI---WAKTGSPSITVtgqevaDSWYKEEKNYNFFKPGH----------QP 677
Cdd:cd18813    29 VELERSAEAWAETCLWEHGPAHLLPSIGQNLgahWGRYRPPTFHV------QAWYDEVRDFSYPYPQEcnpycpfrcsGP 102

                          90       100
                  ....*....|....*....|
gi 2113642615 678 DTGHFTQMVWKASKEVGVGI 697
Cdd:cd18813   103 VCTHYTQVVWATSNRIGCAI 122

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of cysteine-rich secretory protein LCCL domain-containing 2; Cysteine-rich secretory protein LCCL domain-containing 2 (CRISPLD2) is also called cysteine-rich secretory protein 11 (CRSIP-11), LCCL domain-containing cysteine-rich secretory protein 2 (LCRISP2), or CAP and LCCL domain containing protein 2 (CAPLD2). It plays a role in the etiology of NSCLP (non-syndromic cleft lip with or without cleft palate). It is required for neural crest cell migration and cell viability during craniofacial development. The CRISPLD2 gene has been identified a glucocorticoid responsive gene that modulates cytokine function in airway smooth muscle cells. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.

Pssm-ID: 349410 Cd Length: 146 Bit Score: 40.35 E-value: 1.23e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615 765 RKDLLNEHNKYR-RVHGSGA----LQLTTPLTQEAQKWADHLVGVRALQNSSTEHGENLWYRWGTDTSLPTGkevAESWY 839
Cdd:cd18816     1 KEEILQLHNKLRgQVYPSASnmeyMTWDDELERSAEAWAQQCIWEHGPTSLLPSIGQNLAVHWGRYRSPAFH---VQSWY 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2113642615 840 NEISKYNFSTPGF------QSGSG----NFTQMVWKGSTQVG 871
Cdd:cd18816    78 DEVKDYTYPYPHEcnpwcpERCSGpmctHYTQIVWATTNKVG 119

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of peptidase inhibitor 15 and similar proteins; This family is composed of peptidase inhibitor 15 (PI15), peptidase inhibitor R3HDML, cysteine-rich secretory protein LCCL domain-containing 1 (CRISPLD1), and cysteine-rich secretory protein LCCL domain-containing 2 (CRISPLD2). PI15 is a serine protease inhibitor which displays weak inhibitory activity against trypsin and may play a role in facial patterning during embryonic development. The PI15 gene is a candidate gene for abdominal aortic internal elastic lamina ruptures in the rat. R3HDML is a putative serine protease inhibitor, whose gene may be associated with clinical dimensions of schizophrenia. CRISPLD1 may play a role in NSCLP (nonsyndromic cleft lip with or without cleft palate) through the interaction with CRISPLD2 and folate pathway genes. plays a role in the etiology of NSCLP and is required for neural crest cell migration and cell viability during craniofacial development. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.

Pssm-ID: 349406 Cd Length: 146 Bit Score: 39.12 E-value: 2.60e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615  24 QDFLDAHNKYRAlHGSPP------LQLNTDLCESSQKWADHLLSIRTVRHSDTEYGENIDYKSSS--SPKVLagnapVDS 95
Cdd:cd18812     2 NAILDYHNKLRG-QVYPPaanmeyMVWDKELARSAEAWATQCIWEHGPSSLLRSIGQNLSAHWGRyrSPVFL-----VKS 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615  96 WYSEIKNYDFSKPG----------FSVSTGHFTQVVWKESKEVGFGVATDSK---------KAYYVVAQY 146
Cdd:cd18812    76 WYDEVKDYLFPYPRdcnphcpwrcSGPMCTHYTQMVWATSNRIGCAIHTCSNmnvwgnvwhRAVYLVCNY 145

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of peptidase inhibitor R3HDML; Peptidase inhibitor R3HDML, also called cysteine-rich secretory protein R3HDML, is a putative serine protease inhibitor. The R3HDML gene may be associated with clinical dimensions of schizophrenia. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.

Pssm-ID: 349409 Cd Length: 146 Bit Score: 39.11 E-value: 3.25e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615 238 LCRSAQAWADHLLsiqtlkhsgTDHGENLYYKY------SSSTRELPGQEPVESWYDEIKNYDFGRP---GFR------- 301
Cdd:cd18815    31 LAKSAEAWAAQCV---------WEHGPPQLMRYigqnlsIHSGRYRSIVDLVKSWYDERQHYSFPHPrecNPRcpskcsg 101

                          90       100
                  ....*....|....*....|....*.
gi 2113642615 302 SNTGHFTQVVWKDSKEVGVGIATDGN 327
Cdd:cd18815   102 AVCSHYTQMVWASSNRIGCAVHTCSN 127

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of cysteine-rich secretory protein LCCL domain-containing 2; Cysteine-rich secretory protein LCCL domain-containing 2 (CRISPLD2) is also called cysteine-rich secretory protein 11 (CRSIP-11), LCCL domain-containing cysteine-rich secretory protein 2 (LCRISP2), or CAP and LCCL domain containing protein 2 (CAPLD2). It plays a role in the etiology of NSCLP (non-syndromic cleft lip with or without cleft palate). It is required for neural crest cell migration and cell viability during craniofacial development. The CRISPLD2 gene has been identified a glucocorticoid responsive gene that modulates cytokine function in airway smooth muscle cells. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.

Pssm-ID: 349410 Cd Length: 146 Bit Score: 38.81 E-value: 3.53e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615 613 ISQDAQKWAEHLLtlktLKHSDT----SCGENI---WAKTGSPSITVtgqevaDSWYKEEKNYNFFKPgHQ--------- 676
Cdd:cd18816    31 LERSAEAWAQQCI----WEHGPTsllpSIGQNLavhWGRYRSPAFHV------QSWYDEVKDYTYPYP-HEcnpwcperc 99

                          90       100
                  ....*....|....*....|...
gi 2113642615 677 --PDTGHFTQMVWKASKEVGVGI 697
Cdd:cd18816   100 sgPMCTHYTQIVWATTNKVGCAV 122

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of peptidase inhibitor 15 and similar proteins; This family is composed of peptidase inhibitor 15 (PI15), peptidase inhibitor R3HDML, cysteine-rich secretory protein LCCL domain-containing 1 (CRISPLD1), and cysteine-rich secretory protein LCCL domain-containing 2 (CRISPLD2). PI15 is a serine protease inhibitor which displays weak inhibitory activity against trypsin and may play a role in facial patterning during embryonic development. The PI15 gene is a candidate gene for abdominal aortic internal elastic lamina ruptures in the rat. R3HDML is a putative serine protease inhibitor, whose gene may be associated with clinical dimensions of schizophrenia. CRISPLD1 may play a role in NSCLP (nonsyndromic cleft lip with or without cleft palate) through the interaction with CRISPLD2 and folate pathway genes. plays a role in the etiology of NSCLP and is required for neural crest cell migration and cell viability during craniofacial development. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.

Pssm-ID: 349406 Cd Length: 146 Bit Score: 38.73 E-value: 4.34e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113642615 612 RISQDAQKWAEHLLTLKTLKHSDTSCGENIWAKTG---SPSITVtgqevaDSWYKEEKNYNFFKPGH----------QPD 678
Cdd:cd18812    30 ELARSAEAWATQCIWEHGPSSLLRSIGQNLSAHWGryrSPVFLV------KSWYDEVKDYLFPYPRDcnphcpwrcsGPM 103

                          90
                  ....*....|....*....
gi 2113642615 679 TGHFTQMVWKASKEVGVGI 697
Cdd:cd18812   104 CTHYTQMVWATSNRIGCAI 122