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Conserved domains on  [gi|2217350693|ref|XP_047271659|]
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AF4/FMR2 family member 1 isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AF-4 pfam05110
AF-4 proto-oncoprotein N-terminal region; This family consists of AF4 (Proto-oncogene AF4) and ...
 15-526 2.44e-180

AF-4 proto-oncoprotein N-terminal region; This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homolog Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.


:

Pssm-ID: 461550 [Multi-domain]  Cd Length: 514  Bit Score: 540.10  E-value: 2.44e-180
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217350693   15 YNDDRNLLRIREKERRNQEAHQEKEAFPEKIPLFGEPYKTAKGDELSSRIQNMLGNYEEVKEFLSTKSHTHRLDASENR- 93
Cdd:pfam05110    1 YNEDRNLLRIREWERRNQEVQQEKDLFPENFPLFGEPYKTNKGDELSSRIQNMLGNYEEMKELITNKSNQHLVGIPKNSv 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217350693   94 ----LGKPKYPLIPDKGSSiPSSSFHTSVHHQSIHTPASGPLSVGnISHNPKMAQPRTEPMPSLHAKSCGPPDSQHLTQD 169
Cdd:pfam05110   81 pqtpQEKPDQPFFPDKTSG-LPPSFHTSSHSQPMGPPSSSSPSVS-SSQSQKKSQARTEPAHGGHSSSGSQSSQRSQGQS 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217350693  170 RL--GQEGFGSSHHKKGDRRADGDHCASvtDSAPERELSPLISLPSPVPPL-SPIHSNQQTLPRTQGSSKVHGssnnsKG 246
Cdd:pfam05110  159 RSkgGQESHSSSHHKRQERREDLFSCAS--LSHSLEELSPLLSSLSSPVKPlSPSHSRQHTGSKAQNSSDHHG-----KE 231

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217350693  247 YCPAKSPKDLAVKVHDKETPQDSLVA-PAQPPSQTFPPPsLPSKSVAMQQKPTAYVRPMDGQDQAPSESPELKPLPEDYR 325
Cdd:pfam05110  232 YSHSKSPRDSEAGSHGPESPSTSLLAsSSQLSSQTFPPS-LPSKTSAMQQKPTAYVRPMDGQDQAPSESPELKPSPEDYH 310

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217350693  326 QQTFEK-TDLKVPAKAKLTKLKMPSQSVE-TYSNEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSS 403
Cdd:pfam05110  311 GQSYGKlSDLKANAKAKLSKLKIPSQPLEqSLSNDVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKESQHVTS 390

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217350693  404 VTQNQKQYDTSSKTHSNSQQGTsSMLEDDLQLSDSEDSDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDS 483
Cdd:pfam05110  391 GYQNQKQYDAPSKTLPTSQQGT-SMLEDDLKLSSSEDSDDDQAPEKPPPSSAPPSAPQSQPNSVASAHSSSGESGSSSDS 469

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*
gi 2217350693  484 DSSSD--SESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLT 526
Cdd:pfam05110  470 ESSSEsdSESESSSSDSEANEPPRSATPEPEPPSSNKWQLDNWLN 514
AF-4_C pfam18876
AF-4 proto-oncoprotein C-terminal region; This family consists of AF4 (Proto-oncogene AF4) and ...
 956-1217 9.58e-137

AF-4 proto-oncoprotein C-terminal region; This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homolog Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.


:

Pssm-ID: 465894  Cd Length: 262  Bit Score: 415.99  E-value: 9.58e-137
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217350693  956 SKPGKPQVKFDKQQ--ADLHMREAKKMKQKAELMTDRVGKAFKYLEAVLSFIECGIATESESQSSKSAYSVYSETVDLIK 1033
Cdd:pfam18876    1 SKPRRPQLKFEDRQhsADYYMQEAKKLKHKADALSDKFGKAFKYLDAALSFIECGIAMESDPQEAKSPYTMYSETVELIK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217350693 1034 FIMSLKSFSDATAPTQEKIFAVLCMRCQSILNMAMFRCKKDIAIKYSRTLNKHFESSSKVAQAPSPCIARSTGTPSPLSP 1113
Cdd:pfam18876   81 YVMKLKNFTDPSATTAEKIFAVLCLRCQSLLYMAMFRLKKDTAIKYSRTLNEHFKNSSKVAQAPSPCVAKSTGTPSPLSP 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217350693 1114 MPSPASSVgsQSSAGSVGSSGVAATISTPVTIQNMTSSYVTITSHVLTAFDLWEQAEALTRKNKEFFARLSTNVCTLALN 1193
Cdd:pfam18876  161 MPSPASSV--SSQSGSSGSSGSSSSVSIPQRIHQMASSYVNITSNFLYAYEIWEQAEALARENKEFFAELDTVMGPLALN 238

                          250       260
                   ....*....|....*....|....
gi 2217350693 1194 SSLVDLVHYTRQGFQQLQELTKTP 1217
Cdd:pfam18876  239 SSMTELVRYTRQGLHWLRLDAKLP 262
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 532-799 7.31e-07

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.17  E-value: 7.31e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217350693  532 AAPPEGPRSTePPRRHPESKGSSDSATSQEHSESKDP--------------PPKSSSKAPRAPPEAPHPGKRSCQKSPAQ 597
Cdd:PHA03247  2769 PAPPAAPAAG-PPRRLTRPAVASLSESRESLPSPWDPadppaavlapaaalPPAASPAGPLPPPTSAQPTAPPPPPGPPP 2847

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217350693  598 ----------------QEPPQRQTVGTkqPKKPVKASARAGSRTSLQGEREPGLLPYGS--RDQTSKDKPKVKTKGRPRA 659
Cdd:PHA03247  2848 pslplggsvapggdvrRRPPSRSPAAK--PAAPARPPVRRLARPAVSRSTESFALPPDQpeRPPQPQAPPPPQPQPQPPP 2925

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217350693  660 AASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDN----------VEDRTPEHFALVPLTESQGPP-HSGSGSRTS 728
Cdd:PHA03247  2926 PPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLgalvpgrvavPRFRVPQPAPSREAPASSTPPlTGHSLSRVS 3005

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217350693  729 GCRQAVVVQEDSrkDRLPLPLRDTKLLSPLRDTPPPQSLMVKIT--LDLLSRIPQPPGKGSRQRKAEDKQPPA 799
Cdd:PHA03247  3006 SWASSLALHEET--DPPPVSLKQTLWPPDDTEDSDADSLFDSDSerSDLEALDPLPPEPHDPFAHEPDPATPE 3076
 
Name Accession Description Interval E-value
AF-4 pfam05110
AF-4 proto-oncoprotein N-terminal region; This family consists of AF4 (Proto-oncogene AF4) and ...
 15-526 2.44e-180

AF-4 proto-oncoprotein N-terminal region; This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homolog Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.


Pssm-ID: 461550 [Multi-domain]  Cd Length: 514  Bit Score: 540.10  E-value: 2.44e-180
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217350693   15 YNDDRNLLRIREKERRNQEAHQEKEAFPEKIPLFGEPYKTAKGDELSSRIQNMLGNYEEVKEFLSTKSHTHRLDASENR- 93
Cdd:pfam05110    1 YNEDRNLLRIREWERRNQEVQQEKDLFPENFPLFGEPYKTNKGDELSSRIQNMLGNYEEMKELITNKSNQHLVGIPKNSv 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217350693   94 ----LGKPKYPLIPDKGSSiPSSSFHTSVHHQSIHTPASGPLSVGnISHNPKMAQPRTEPMPSLHAKSCGPPDSQHLTQD 169
Cdd:pfam05110   81 pqtpQEKPDQPFFPDKTSG-LPPSFHTSSHSQPMGPPSSSSPSVS-SSQSQKKSQARTEPAHGGHSSSGSQSSQRSQGQS 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217350693  170 RL--GQEGFGSSHHKKGDRRADGDHCASvtDSAPERELSPLISLPSPVPPL-SPIHSNQQTLPRTQGSSKVHGssnnsKG 246
Cdd:pfam05110  159 RSkgGQESHSSSHHKRQERREDLFSCAS--LSHSLEELSPLLSSLSSPVKPlSPSHSRQHTGSKAQNSSDHHG-----KE 231

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217350693  247 YCPAKSPKDLAVKVHDKETPQDSLVA-PAQPPSQTFPPPsLPSKSVAMQQKPTAYVRPMDGQDQAPSESPELKPLPEDYR 325
Cdd:pfam05110  232 YSHSKSPRDSEAGSHGPESPSTSLLAsSSQLSSQTFPPS-LPSKTSAMQQKPTAYVRPMDGQDQAPSESPELKPSPEDYH 310

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217350693  326 QQTFEK-TDLKVPAKAKLTKLKMPSQSVE-TYSNEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSS 403
Cdd:pfam05110  311 GQSYGKlSDLKANAKAKLSKLKIPSQPLEqSLSNDVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKESQHVTS 390

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217350693  404 VTQNQKQYDTSSKTHSNSQQGTsSMLEDDLQLSDSEDSDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDS 483
Cdd:pfam05110  391 GYQNQKQYDAPSKTLPTSQQGT-SMLEDDLKLSSSEDSDDDQAPEKPPPSSAPPSAPQSQPNSVASAHSSSGESGSSSDS 469

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*
gi 2217350693  484 DSSSD--SESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLT 526
Cdd:pfam05110  470 ESSSEsdSESESSSSDSEANEPPRSATPEPEPPSSNKWQLDNWLN 514
AF-4_C pfam18876
AF-4 proto-oncoprotein C-terminal region; This family consists of AF4 (Proto-oncogene AF4) and ...
 956-1217 9.58e-137

AF-4 proto-oncoprotein C-terminal region; This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homolog Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.


Pssm-ID: 465894  Cd Length: 262  Bit Score: 415.99  E-value: 9.58e-137
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217350693  956 SKPGKPQVKFDKQQ--ADLHMREAKKMKQKAELMTDRVGKAFKYLEAVLSFIECGIATESESQSSKSAYSVYSETVDLIK 1033
Cdd:pfam18876    1 SKPRRPQLKFEDRQhsADYYMQEAKKLKHKADALSDKFGKAFKYLDAALSFIECGIAMESDPQEAKSPYTMYSETVELIK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217350693 1034 FIMSLKSFSDATAPTQEKIFAVLCMRCQSILNMAMFRCKKDIAIKYSRTLNKHFESSSKVAQAPSPCIARSTGTPSPLSP 1113
Cdd:pfam18876   81 YVMKLKNFTDPSATTAEKIFAVLCLRCQSLLYMAMFRLKKDTAIKYSRTLNEHFKNSSKVAQAPSPCVAKSTGTPSPLSP 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217350693 1114 MPSPASSVgsQSSAGSVGSSGVAATISTPVTIQNMTSSYVTITSHVLTAFDLWEQAEALTRKNKEFFARLSTNVCTLALN 1193
Cdd:pfam18876  161 MPSPASSV--SSQSGSSGSSGSSSSVSIPQRIHQMASSYVNITSNFLYAYEIWEQAEALARENKEFFAELDTVMGPLALN 238

                          250       260
                   ....*....|....*....|....
gi 2217350693 1194 SSLVDLVHYTRQGFQQLQELTKTP 1217
Cdd:pfam18876  239 SSMTELVRYTRQGLHWLRLDAKLP 262
PHA03247 PHA03247
large tegument protein UL36; Provisional
 532-799 7.31e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.17  E-value: 7.31e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217350693  532 AAPPEGPRSTePPRRHPESKGSSDSATSQEHSESKDP--------------PPKSSSKAPRAPPEAPHPGKRSCQKSPAQ 597
Cdd:PHA03247  2769 PAPPAAPAAG-PPRRLTRPAVASLSESRESLPSPWDPadppaavlapaaalPPAASPAGPLPPPTSAQPTAPPPPPGPPP 2847

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217350693  598 ----------------QEPPQRQTVGTkqPKKPVKASARAGSRTSLQGEREPGLLPYGS--RDQTSKDKPKVKTKGRPRA 659
Cdd:PHA03247  2848 pslplggsvapggdvrRRPPSRSPAAK--PAAPARPPVRRLARPAVSRSTESFALPPDQpeRPPQPQAPPPPQPQPQPPP 2925

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217350693  660 AASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDN----------VEDRTPEHFALVPLTESQGPP-HSGSGSRTS 728
Cdd:PHA03247  2926 PPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLgalvpgrvavPRFRVPQPAPSREAPASSTPPlTGHSLSRVS 3005

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217350693  729 GCRQAVVVQEDSrkDRLPLPLRDTKLLSPLRDTPPPQSLMVKIT--LDLLSRIPQPPGKGSRQRKAEDKQPPA 799
Cdd:PHA03247  3006 SWASSLALHEET--DPPPVSLKQTLWPPDDTEDSDADSLFDSDSerSDLEALDPLPPEPHDPFAHEPDPATPE 3076
AF4_int pfam18875
AF4 interaction motif; This short motif found in the AF4 protein interacts with AF9.
 767-781 1.27e-03

AF4 interaction motif; This short motif found in the AF4 protein interacts with AF9.


Pssm-ID: 436798  Cd Length: 15  Bit Score: 37.02  E-value: 1.27e-03
                           10
                   ....*....|....*
gi 2217350693  767 LMVKITLDLLSRIPQ 781
Cdd:pfam18875    1 LVVKIDLSLLSRVPQ 15
 
Name Accession Description Interval E-value
AF-4 pfam05110
AF-4 proto-oncoprotein N-terminal region; This family consists of AF4 (Proto-oncogene AF4) and ...
 15-526 2.44e-180

AF-4 proto-oncoprotein N-terminal region; This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homolog Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.


Pssm-ID: 461550 [Multi-domain]  Cd Length: 514  Bit Score: 540.10  E-value: 2.44e-180
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217350693   15 YNDDRNLLRIREKERRNQEAHQEKEAFPEKIPLFGEPYKTAKGDELSSRIQNMLGNYEEVKEFLSTKSHTHRLDASENR- 93
Cdd:pfam05110    1 YNEDRNLLRIREWERRNQEVQQEKDLFPENFPLFGEPYKTNKGDELSSRIQNMLGNYEEMKELITNKSNQHLVGIPKNSv 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217350693   94 ----LGKPKYPLIPDKGSSiPSSSFHTSVHHQSIHTPASGPLSVGnISHNPKMAQPRTEPMPSLHAKSCGPPDSQHLTQD 169
Cdd:pfam05110   81 pqtpQEKPDQPFFPDKTSG-LPPSFHTSSHSQPMGPPSSSSPSVS-SSQSQKKSQARTEPAHGGHSSSGSQSSQRSQGQS 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217350693  170 RL--GQEGFGSSHHKKGDRRADGDHCASvtDSAPERELSPLISLPSPVPPL-SPIHSNQQTLPRTQGSSKVHGssnnsKG 246
Cdd:pfam05110  159 RSkgGQESHSSSHHKRQERREDLFSCAS--LSHSLEELSPLLSSLSSPVKPlSPSHSRQHTGSKAQNSSDHHG-----KE 231

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217350693  247 YCPAKSPKDLAVKVHDKETPQDSLVA-PAQPPSQTFPPPsLPSKSVAMQQKPTAYVRPMDGQDQAPSESPELKPLPEDYR 325
Cdd:pfam05110  232 YSHSKSPRDSEAGSHGPESPSTSLLAsSSQLSSQTFPPS-LPSKTSAMQQKPTAYVRPMDGQDQAPSESPELKPSPEDYH 310

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217350693  326 QQTFEK-TDLKVPAKAKLTKLKMPSQSVE-TYSNEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSS 403
Cdd:pfam05110  311 GQSYGKlSDLKANAKAKLSKLKIPSQPLEqSLSNDVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKESQHVTS 390

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217350693  404 VTQNQKQYDTSSKTHSNSQQGTsSMLEDDLQLSDSEDSDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDS 483
Cdd:pfam05110  391 GYQNQKQYDAPSKTLPTSQQGT-SMLEDDLKLSSSEDSDDDQAPEKPPPSSAPPSAPQSQPNSVASAHSSSGESGSSSDS 469

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*
gi 2217350693  484 DSSSD--SESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLT 526
Cdd:pfam05110  470 ESSSEsdSESESSSSDSEANEPPRSATPEPEPPSSNKWQLDNWLN 514
AF-4_C pfam18876
AF-4 proto-oncoprotein C-terminal region; This family consists of AF4 (Proto-oncogene AF4) and ...
 956-1217 9.58e-137

AF-4 proto-oncoprotein C-terminal region; This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homolog Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.


Pssm-ID: 465894  Cd Length: 262  Bit Score: 415.99  E-value: 9.58e-137
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217350693  956 SKPGKPQVKFDKQQ--ADLHMREAKKMKQKAELMTDRVGKAFKYLEAVLSFIECGIATESESQSSKSAYSVYSETVDLIK 1033
Cdd:pfam18876    1 SKPRRPQLKFEDRQhsADYYMQEAKKLKHKADALSDKFGKAFKYLDAALSFIECGIAMESDPQEAKSPYTMYSETVELIK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217350693 1034 FIMSLKSFSDATAPTQEKIFAVLCMRCQSILNMAMFRCKKDIAIKYSRTLNKHFESSSKVAQAPSPCIARSTGTPSPLSP 1113
Cdd:pfam18876   81 YVMKLKNFTDPSATTAEKIFAVLCLRCQSLLYMAMFRLKKDTAIKYSRTLNEHFKNSSKVAQAPSPCVAKSTGTPSPLSP 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217350693 1114 MPSPASSVgsQSSAGSVGSSGVAATISTPVTIQNMTSSYVTITSHVLTAFDLWEQAEALTRKNKEFFARLSTNVCTLALN 1193
Cdd:pfam18876  161 MPSPASSV--SSQSGSSGSSGSSSSVSIPQRIHQMASSYVNITSNFLYAYEIWEQAEALARENKEFFAELDTVMGPLALN 238

                          250       260
                   ....*....|....*....|....
gi 2217350693 1194 SSLVDLVHYTRQGFQQLQELTKTP 1217
Cdd:pfam18876  239 SSMTELVRYTRQGLHWLRLDAKLP 262
PHA03247 PHA03247
large tegument protein UL36; Provisional
 532-799 7.31e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.17  E-value: 7.31e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217350693  532 AAPPEGPRSTePPRRHPESKGSSDSATSQEHSESKDP--------------PPKSSSKAPRAPPEAPHPGKRSCQKSPAQ 597
Cdd:PHA03247  2769 PAPPAAPAAG-PPRRLTRPAVASLSESRESLPSPWDPadppaavlapaaalPPAASPAGPLPPPTSAQPTAPPPPPGPPP 2847

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217350693  598 ----------------QEPPQRQTVGTkqPKKPVKASARAGSRTSLQGEREPGLLPYGS--RDQTSKDKPKVKTKGRPRA 659
Cdd:PHA03247  2848 pslplggsvapggdvrRRPPSRSPAAK--PAAPARPPVRRLARPAVSRSTESFALPPDQpeRPPQPQAPPPPQPQPQPPP 2925

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217350693  660 AASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDN----------VEDRTPEHFALVPLTESQGPP-HSGSGSRTS 728
Cdd:PHA03247  2926 PPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLgalvpgrvavPRFRVPQPAPSREAPASSTPPlTGHSLSRVS 3005

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217350693  729 GCRQAVVVQEDSrkDRLPLPLRDTKLLSPLRDTPPPQSLMVKIT--LDLLSRIPQPPGKGSRQRKAEDKQPPA 799
Cdd:PHA03247  3006 SWASSLALHEET--DPPPVSLKQTLWPPDDTEDSDADSLFDSDSerSDLEALDPLPPEPHDPFAHEPDPATPE 3076
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
533-697 3.21e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 45.23  E-value: 3.21e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217350693  533 APPEGPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRScQKSPAQQEPPQRQTVGTKQPK 612
Cdd:PRK07003   366 GAPGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRA-EAPPAAPAPPATADRGDDAAD 444

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217350693  613 KPVKASARAGSRTSL-----------QGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSS 681
Cdd:PRK07003   445 GDAPVPAKANARASAdsrcderdaqpPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPAA 524

                          170
                   ....*....|....*.
gi 2217350693  682 LPAPSKALSGPEPAKD 697
Cdd:PRK07003   525 AAPPAPEARPPTPAAA 540
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
528-708 8.67e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 43.71  E-value: 8.67e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217350693  528 VSQPAAPPEGPRSTEPPRRHPE-----SKGSSDSATSQEHSESKDPPPKSSSKAPR-----------APPEAPHPGKRSC 591
Cdd:PRK12323   382 VAQPAPAAAAPAAAAPAPAAPPaapaaAPAAAAAARAVAAAPARRSPAPEALAAARqasargpggapAPAPAPAAAPAAA 461

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217350693  592 QKSPAQQEPPQRQTVGTKQPKKPVKASARAGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPP 671
Cdd:PRK12323   462 ARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGWVAESIPDPATADPDDAFETL 541

                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 2217350693  672 SSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFA 708
Cdd:PRK12323   542 APAPAAAPAPRAAAATEPVVAPRPPRASASGLPDMFD 578
AF4_int pfam18875
AF4 interaction motif; This short motif found in the AF4 protein interacts with AF9.
 767-781 1.27e-03

AF4 interaction motif; This short motif found in the AF4 protein interacts with AF9.


Pssm-ID: 436798  Cd Length: 15  Bit Score: 37.02  E-value: 1.27e-03
                           10
                   ....*....|....*
gi 2217350693  767 LMVKITLDLLSRIPQ 781
Cdd:pfam18875    1 LVVKIDLSLLSRVPQ 15
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 529-709 1.69e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 42.67  E-value: 1.69e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217350693  529 SQPAAPPEGPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGT 608
Cdd:PRK07764   634 AAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQ 713

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217350693  609 KQPKKPVKASARAGSRTSLQGEREPGLLPYGSRDQTSKDKPKVktKGRPRAAASNEPKPAVPPSSEKKkhksslPAPSKA 688
Cdd:PRK07764   714 ADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPA--QPPPPPAPAPAAAPAAAPPPSPP------SEEEEM 785

                          170       180
                   ....*....|....*....|.
gi 2217350693  689 LSGPEPAKDNVEDRTPEHFAL 709
Cdd:PRK07764   786 AEDDAPSMDDEDRRDAEEVAM 806
dnaA PRK14086
chromosomal replication initiator protein DnaA;
530-695 2.56e-03

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 42.12  E-value: 2.56e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217350693  530 QPAAPPEGPRSTEPPRRHPESKGSSDSATSQEhSESKDPPPKSSSKAPRAPPEAP---HPGKRSCQKSPAQQEPPQRQTV 606
Cdd:PRK14086    94 EPAPPPPHARRTSEPELPRPGRRPYEGYGGPR-ADDRPPGLPRQDQLPTARPAYPayqQRPEPGAWPRAADDYGWQQQRL 172

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217350693  607 GTKQPKKPvkASARAGSRTSLQGEREPGL----LPYGSRDQT----SKDKPKVKTKGRPRAAASNE------PKPAVPPS 672
Cdd:PRK14086   173 GFPPRAPY--ASPASYAPEQERDREPYDAgrpeYDQRRRDYDhprpDWDRPRRDRTDRPEPPPGAGhvhrggPGPPERDD 250

                          170       180
                   ....*....|....*....|...
gi 2217350693  673 SEKKKHKSSLPAPSKALSGPEPA 695
Cdd:PRK14086   251 APVVPIRPSAPGPLAAQPAPAPG 273
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 531-622 3.07e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 41.62  E-value: 3.07e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217350693  531 PAAPPEGPRSTEPPRRHPESKGSSDSATSQEHSeskdPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQ 610
Cdd:PRK14951   389 PAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAA----PPAPVAAPAAAAPAAAPAAAPAAVALAPAPPAQAAPETVAIPV 464

                           90
                   ....*....|..
gi 2217350693  611 PKKPVKASARAG 622
Cdd:PRK14951   465 RVAPEPAVASAA 476
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 519-764 4.38e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 41.31  E-value: 4.38e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217350693  519 WQLDNWLTKVSQPAA-------------PPEGPRSTEPPRRHPESKGSSD---------------SATSQEHSESKDP-- 568
Cdd:PHA03307   170 RQAALPLSSPEETARapssppaepppstPPAAASPRPPRRSSPISASASSpapapgrsaaddagaSSSDSSSSESSGCgw 249

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217350693  569 --------PPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKASARAGSRTSLQGEREPGLLPYGS 640
Cdd:PHA03307   250 gpenecplPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSST 329

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217350693  641 RDQTSKDKPKVKTKGRP--RAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDnvedrtpehfALVPLTESQGP 718
Cdd:PHA03307   330 SSSSESSRGAAVSPGPSpsRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRR----------RARAAVAGRAR 399

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*..
gi 2217350693  719 PHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRD-TKLLSPLRDTPPP 764
Cdd:PHA03307   400 RRDATGRFPAGRPRPSPLDAGAASGAFYARYPLlTPSGEPWPGSPPP 446
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
529-719 5.05e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.01  E-value: 5.05e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217350693  529 SQPAAPPEGPRSTEPPRRHPESkgssdsatsqehseSKDPPPKSSSKAPRAPPEAPHPGkrscqkspaqqePPQRQTVGT 608
Cdd:PRK12323   372 AGPATAAAAPVAQPAPAAAAPA--------------AAAPAPAAPPAAPAAAPAAAAAA------------RAVAAAPAR 425

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217350693  609 KQPKKPVKASARAGSRTSLQGEREPGLLPygsrdqtskdkPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPskA 688
Cdd:PRK12323   426 RSPAPEALAAARQASARGPGGAPAPAPAP-----------AAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAP--A 492

                          170       180       190
                   ....*....|....*....|....*....|.
gi 2217350693  689 LSGPEPAKDnvedrTPEHFALVPLTESQGPP 719
Cdd:PRK12323   493 DDDPPPWEE-----LPPEFASPAPAQPDAAP 518
PHA03325 PHA03325
nuclear-egress-membrane-like protein; Provisional
 531-671 6.71e-03

nuclear-egress-membrane-like protein; Provisional


Pssm-ID: 223044  Cd Length: 418  Bit Score: 40.25  E-value: 6.71e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217350693  531 PAAPPEGPRSTEPPRRHPESKGSSDSATSQE-------HSESKDPPPKSSSKAPrAPPEAPHPGKRSCQKSP------AQ 597
Cdd:PHA03325   260 SAFMLNSSLPTSAPKRRSRRAGAMRAAAGETadladddGSEHSDPEPLPASLPP-PPVRRPRVKHPEAGKEEpdgarnAE 338

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217350693  598 QEPPQRQTVGTKQPKKPVKASARAGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPP 671
Cdd:PHA03325   339 AKEPAQPATSTSSKGSSSAQNKDSGSTGPGSSLAAASSFLEDDDFGSPPLDLTTSLRHMPSPSVTSAPEPPSIP 412
PHA03247 PHA03247
large tegument protein UL36; Provisional
 531-905 7.14e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 7.14e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217350693  531 PAAPPEGPRSTEPPRRhPESKGSSDSATSQEHSES--------------KDPPPKSSSKAPrAPPEAPHPGKRSCQKSPA 596
Cdd:PHA03247  2557 PAAPPAAPDRSVPPPR-PAPRPSEPAVTSRARRPDappqsarprapvddRGDPRGPAPPSP-LPPDTHAPDPPPPSPSPA 2634

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217350693  597 QQEPPQRQTVGTKQPKKPVKASAraGSRTSL-QGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEK 675
Cdd:PHA03247  2635 ANEPDPHPPPTVPPPERPRDDPA--PGRVSRpRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAP 2712

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217350693  676 KKHKSSLPAPSKALSGPEpakdnvedrtpehfALVPLTESQGPPHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDtkll 755
Cdd:PHA03247  2713 HALVSATPLPPGPAAARQ--------------ASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAA---- 2774

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217350693  756 splRDTPPPQslmvkitldllsRIPQPPGKGSRQRKAEDKQPPAGKKHSSEKRSSDSSSKLAKKRKGeaerdcdnkkirl 835
Cdd:PHA03247  2775 ---PAAGPPR------------RLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAG------------- 2826

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217350693  836 ekeiKSQSSSSSSSHKESSKTKPSRPS-----SQSSKKEMLPPPPVSSSSQKPAKPALKRSRREADTCGQDPPKS 905
Cdd:PHA03247  2827 ----PLPPPTSAQPTAPPPPPGPPPPSlplggSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTES 2897
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 538-711 7.29e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.74  E-value: 7.29e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217350693  538 PRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKA 617
Cdd:PRK07764   376 ARLERLERRLGVAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPS 455

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217350693  618 SARAGSrtslqgerepgllpyGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSekkkhksslPAPSKALSGPEPAkD 697
Cdd:PRK07764   456 PPPAAA---------------PSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAA---------PAAPAAPAGADDA-A 510

                          170
                   ....*....|....
gi 2217350693  698 NVEDRTPEHFALVP 711
Cdd:PRK07764   511 TLRERWPEILAAVP 524
DUF4045 pfam13254
Domain of unknown function (DUF4045); This presumed domain is functionally uncharacterized. ...
 532-671 7.55e-03

Domain of unknown function (DUF4045); This presumed domain is functionally uncharacterized. This domain family is found in bacteria and eukaryotes, and is typically between 384 and 430 amino acids in length.


Pssm-ID: 433066 [Multi-domain]  Cd Length: 415  Bit Score: 40.15  E-value: 7.55e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217350693  532 AAPPEGPRSTEPPRRHpeSKGSSDSATSQEHSESKDPPPKSSSkaPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQP 611
Cdd:pfam13254  202 EVTPVGLMRSPAPGGH--SKSPSVSGISADSSPTKEEPSEEAD--TLSTDKEQSPAPTSASEPPPKTKELPKDSEEPAAP 277

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217350693  612 KKPVKASARA------GSRTSLQGEREPGLLPYGSRdqTSKDKPKVKTkgrPRAAASNEPKPAVPP 671
Cdd:pfam13254  278 SKSAEASTEKkepdteSSPETSSEKSAPSLLSPVSK--ASIDKPLSSP---DRDPLSPKPKPQSPP 338
PHA03247 PHA03247
large tegument protein UL36; Provisional
 527-762 8.59e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 8.59e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217350693  527 KVSQPAAPPEGPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPE----------APHPGKRSCQKSPA 596
Cdd:PHA03247   274 GATGPPPPPEAAAPNGAAAPPDGVWGAALAGAPLALPAPPDPPPPAPAGDAEEEDDedgamevvspLPRPRQHYPLGFPK 353

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217350693  597 QQEPP-------QRQTVGTKQPKkpvKASARAGSRTSLQGEREPGLLPYGSRDQTSKDKP---KVKTKGRPRAAASNEPK 666
Cdd:PHA03247   354 RRRPTwtppsslEDLSAGRHHPK---RASLPTRKRRSARHAATPFARGPGGDDQTRPAAPvpaSVPTPAPTPVPASAPPP 430

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217350693  667 PAVPPSSEKKKHKSSlPAPSKALSGPEPAKDNVEDRTPE--HFALVPLTESQGP--------------PHSGSGSRTSGC 730
Cdd:PHA03247   431 PATPLPSAEPGSDDG-PAPPPERQPPAPATEPAPDDPDDatRKALDALRERRPPeppgadlaellgrhPDTAGTVVRLAA 509

                          250       260       270
                   ....*....|....*....|....*....|..
gi 2217350693  731 RQAVVVQEDSRKDRLPLplrdTKLLSPLRDTP 762
Cdd:PHA03247   510 REAAIAREVAECSRLTI----NALRSPFPASP 537
PHA03291 PHA03291
envelope glycoprotein I; Provisional
 525-600 9.60e-03

envelope glycoprotein I; Provisional


Pssm-ID: 223033 [Multi-domain]  Cd Length: 401  Bit Score: 39.94  E-value: 9.60e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2217350693  525 LTKVSQPAAPPEGPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAP--PEAPHPGKRSCQKSPAQQEP 600
Cdd:PHA03291   199 PADVFVPATPRPTPRTTASPETTPTPSTTTSPPSTTIPAPSTTIAAPQAGTTPEAEgtPAPPTPGGGEAPPANATPAP 276
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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