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Conserved domains on  [gi|2217369006|ref|XP_047276974|]
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plexin-A4 isoform X5 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sema_plexin_A4 cd11274
The Sema domain, a protein interacting module, of Plexin A4; Plexin A4 forms a receptor ...
 39-511 0e+00

The Sema domain, a protein interacting module, of Plexin A4; Plexin A4 forms a receptor complex with neuropilins (NRPs) and transduces signals for class 3 semaphorins in the nervous system. It regulates facial nerve development by functioning as a receptor for Sema3A/NRP1. Both plexins A3 and A4 are essential for normal sympathetic development. They function both cooperatively, to regulate the migration of sympathetic neurons, and differentially, to guide sympathetic axons. Plexin A4 is also expressed in lymphoid tissues and functions in the immune system. It negatively regulates T lymphocyte responses. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


:

Pssm-ID: 200535 [Multi-domain]  Cd Length: 473  Bit Score: 1051.85  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006   39 SFVTFRGEPAEGFNHLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHETGPDEDNPKCYPPRIVQTCNEPLTTTNNVNKML 118
Cdd:cd11274      1 FITFTGDQTEWTFNHLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHQTGPDEDNPKCYPPRIVQTCNEPLTLTNNINKML 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  119 LIDYKENRLIACGSLYQGICKLLRLEDLFKLGEPYHKKEHYLSGVNESGSVFGVIVSYSNLDDKLFIATAVDGKPEYFPT 198
Cdd:cd11274     81 LIDYKENRLIACGSLYQGICKLLRLDDLFKLGEPFHKKEHYLSGVNESGSVFGVIVSYSNLDDKLFIATAVDGKPEYFPT 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  199 ISSRKLTKNSEADGMFAYVFHDEFVASMIKIPSDTFTIIPDFDIYYVYGFSSGNFVYFLTLQPEMVSPPGSTTKEQVYTS 278
Cdd:cd11274    161 ISSRKLTKNSEADGMFAYVFHDEFVASMIKIPSDTFTIIPDFDIYYIYGFSSGNFVYFLTLQPEMISPPGSTTKEQVYTS 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  279 KLVRLCKEDTAFNSYVEVPIGCERSGVEYRLLQAAYLSKAGAVLGRTLGVHPDDDLLFTVFSKGQKRKMKSLDESALCIF 358
Cdd:cd11274    241 KLVRLCKEDTAFNSYVEVPIGCEKNGVEYRLLQAAYLSKAGAILARSLGVGPDDDILFTVFSKGQKRKMKSLDESALCIF 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  359 ILKQINDRIKERLQSCYRGEGTLDLAWLKVKDIPCSSALLTIDDNFCGLDMNAPLGVSDMVRGIPVFTEDRDRMTSVIAY 438
Cdd:cd11274    321 VLKEINDRIKDRLQSCYRGEGTLDLAWLKVKDIPCSSALLTIDDNFCGLDMNAPLGVSEMVRGLPVFTEDRDRMTSVIAY 400

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217369006  439 VYKNHSLAFVGTKSGKLKKIRVDGPRGNALQYETVQVVDPGPVLRDMAFSKDHEQLYIMSERQLTRVPVESCG 511
Cdd:cd11274    401 VYKNHSLAFVGTKSGKLKKIRVDGTTKNALQYETVQVVDTGPILRDMAFSKDHEQLYIMSEKQLTRVPVESCG 473
IPT_plexin_repeat3 cd01181
Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1040-1140 8.47e-47

Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238586  Cd Length: 99  Bit Score: 162.59  E-value: 8.47e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006 1040 PTIVRIEPEWSIVSGNTPIAVWGTHLDLIQNPQIRAKHGGKEHINiCEVLNATEMTCQAPALALGPDHQsDLTERPEEFG 1119
Cdd:cd01181      1 PTITRIEPEWSFLSGGTPITVTGTNLNTVQEPRIRVKYGGVEKTS-CKVRNSTLMTCPAPSLALLNRSP-EPGERPVEFG 78

                           90       100
                   ....*....|....*....|.
gi 2217369006 1120 FILDNVQSLLILNKTNFTYYP 1140
Cdd:cd01181     79 LDGDNVQSLLILNRTSFSYYP 99
TIG_2 pfam18020
TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG ...
 708-802 1.12e-39

TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG domains have an Ig-like fold.


:

Pssm-ID: 465619  Cd Length: 94  Bit Score: 142.03  E-value: 1.12e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  708 DKILVPVEVIKPITLKAKNLPQPQSGQRGYECILNIQGSEQRVPALRFNSSSVQCQNTSYSYEGMeINNLPVELTVVWNG 787
Cdd:pfam18020    1 GSILVPVGVEREITLKARNLPLFQSGQLGYECVFEIEGATHVVPASRESSDSITCQEHQFSYSGS-SGELPATFYVTWNG 79

                           90
                   ....*....|....*
gi 2217369006  788 HFNIDNPAQNKVHLY 802
Cdd:pfam18020   80 GHRLDNPANLQVVLY 94
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 955-1038 2.32e-34

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238584  Cd Length: 85  Bit Score: 126.57  E-value: 2.32e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  955 TLSDLKPSRGPMSGGTQVTITGTNLNAGSNVVVMFGKQPCLFHRRSPSYIVCNTTSSDEVLEMKVSVQVDRAKIHQDLVF 1034
Cdd:cd01179      2 SITSLSPSYGPQSGGTRLTITGKHLNAGSSVRVTVGGQPCKILSVSSSQIVCLTPPSASPGEAPVKVLIDGARRLAPLVF 81


                   ....
gi 2217369006 1035 QYVE 1038
Cdd:cd01179     82 TYTE 85
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 858-953 1.44e-26

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238585  Cd Length: 94  Bit Score: 104.71  E-value: 1.44e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  858 PRITEIIPVTGPREGGTKVTIRGENLGLEFRDIASHVKVAGVECSPLVDGYIPAEQIVCEMGEAKPSQHAGFVEICVAVC 937
Cdd:cd01180      1 PVITEFFPLSGPLEGGTRLTICGSNLGLRKNDVRHGVRVGGVPCNPEPPEYSSSEKIVCTTGPAGNPVFNGPVEVTVGHG 80

                           90
                   ....*....|....*.
gi 2217369006  938 rpEFMARSSQLYYFMT 953
Cdd:cd01180     81 --SFRTESSEGFSFVD 94
TIG_plexin pfam17960
TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and ...
 564-654 7.13e-24

TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and Transcription factors) found in plexins.


:

Pssm-ID: 465588  Cd Length: 89  Bit Score: 96.95  E-value: 7.13e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  564 HPNNISVSQY-NVLLVLEtyNVPELSAGVNCTFEDLSEMDGLVVGNQIQCYSPAAKEVPRIiTENGDHHVVQLQLKSKET 642
Cdd:pfam17960    1 TPDNISRTTAtQLTLTVP--NLPALSEGYSCVFGDLTESPATVHDNGVKCATPPPSQLPPI-PTGQDHVTVKLSLRSSET 77

                           90
                   ....*....|..
gi 2217369006  643 GMTFASTSFVFY 654
Cdd:pfam17960   78 GVDFASTNFTFY 89
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
510-548 1.01e-13

domain found in Plexins, Semaphorins and Integrins;


:

Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 66.80  E-value: 1.01e-13
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 2217369006   510 CGQYQSCGECLGSGDPHCGWCVLHNTCTRKERCERSKEP 548
Cdd:smart00423    2 CSKYTSCSECLLARDPYCAWCSSQGRCTSGERCDSRRQN 40
RasGAP super family cl02569
Ras GTPase Activating Domain; RasGAP functions as an enhancer of the hydrolysis of GTP that is ...
 1311-1339 1.66e-11

Ras GTPase Activating Domain; RasGAP functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Proteins having a RasGAP domain include p120GAP, IQGAP, Rab5-activating protein 6, and Neurofibromin, among others. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP exhibit no similarity at their amino acid sequence level. RasGTPases function as molecular switches in a large number of signaling pathways. They are in the on state when bound to GTP, and in the off state when bound to GDP. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


The actual alignment was detected with superfamily member cd12790:

Pssm-ID: 470620 [Multi-domain]  Cd Length: 385  Bit Score: 67.83  E-value: 1.66e-11
                           10        20
                   ....*....|....*....|....*....
gi 2217369006 1311 GIPFLDYRTYTMRVLFPGIEDHPVLRDLE 1339
Cdd:cd12790      1 GIPFLDYRTYAMRVLFPGIEDHPVLRELE 29
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 804-856 3.09e-08

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


:

Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 51.17  E-value: 3.09e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2217369006  804 CGAMReSCGLCLKADpDFACGWCQGPGQCTLRQHCPAQESQWLELSGAKSKCT 856
Cdd:pfam01437    2 CSQYT-SCSSCLAAR-DPYCGWCSSEGRCVRRSACGAPEGNCEEWEQASSKCP 52
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 655-702 1.05e-07

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


:

Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 49.63  E-value: 1.05e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2217369006  655 NCSVHNSCLSCVESP-YRCHWCKYRHVCTHdPKTCSFQEGR----VKLPEDCP 702
Cdd:pfam01437    1 RCSQYTSCSSCLAARdPYCGWCSSEGRCVR-RSACGAPEGNceewEQASSKCP 52
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1142-1222 1.32e-06

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 47.83  E-value: 1.32e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006 1142 PVFEAFGPS-GILElkPGTPIILKGKNLippvagGNVKLNYTVLVGEKPCTVT-VSDVQLLCESP--NLIGRHKVMARVG 1217
Cdd:cd00603      1 PVITSISPSsGPLS--GGTRLTITGSNL------GSGSPRVRVTVGGVPCKVLnVSSTEIVCRTPaaATPGEGPVEVTVD 72


                   ....*
gi 2217369006 1218 GMEYS 1222
Cdd:cd00603     73 GANVS 77
 
Name Accession Description Interval E-value
Sema_plexin_A4 cd11274
The Sema domain, a protein interacting module, of Plexin A4; Plexin A4 forms a receptor ...
 39-511 0e+00

The Sema domain, a protein interacting module, of Plexin A4; Plexin A4 forms a receptor complex with neuropilins (NRPs) and transduces signals for class 3 semaphorins in the nervous system. It regulates facial nerve development by functioning as a receptor for Sema3A/NRP1. Both plexins A3 and A4 are essential for normal sympathetic development. They function both cooperatively, to regulate the migration of sympathetic neurons, and differentially, to guide sympathetic axons. Plexin A4 is also expressed in lymphoid tissues and functions in the immune system. It negatively regulates T lymphocyte responses. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200535 [Multi-domain]  Cd Length: 473  Bit Score: 1051.85  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006   39 SFVTFRGEPAEGFNHLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHETGPDEDNPKCYPPRIVQTCNEPLTTTNNVNKML 118
Cdd:cd11274      1 FITFTGDQTEWTFNHLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHQTGPDEDNPKCYPPRIVQTCNEPLTLTNNINKML 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  119 LIDYKENRLIACGSLYQGICKLLRLEDLFKLGEPYHKKEHYLSGVNESGSVFGVIVSYSNLDDKLFIATAVDGKPEYFPT 198
Cdd:cd11274     81 LIDYKENRLIACGSLYQGICKLLRLDDLFKLGEPFHKKEHYLSGVNESGSVFGVIVSYSNLDDKLFIATAVDGKPEYFPT 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  199 ISSRKLTKNSEADGMFAYVFHDEFVASMIKIPSDTFTIIPDFDIYYVYGFSSGNFVYFLTLQPEMVSPPGSTTKEQVYTS 278
Cdd:cd11274    161 ISSRKLTKNSEADGMFAYVFHDEFVASMIKIPSDTFTIIPDFDIYYIYGFSSGNFVYFLTLQPEMISPPGSTTKEQVYTS 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  279 KLVRLCKEDTAFNSYVEVPIGCERSGVEYRLLQAAYLSKAGAVLGRTLGVHPDDDLLFTVFSKGQKRKMKSLDESALCIF 358
Cdd:cd11274    241 KLVRLCKEDTAFNSYVEVPIGCEKNGVEYRLLQAAYLSKAGAILARSLGVGPDDDILFTVFSKGQKRKMKSLDESALCIF 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  359 ILKQINDRIKERLQSCYRGEGTLDLAWLKVKDIPCSSALLTIDDNFCGLDMNAPLGVSDMVRGIPVFTEDRDRMTSVIAY 438
Cdd:cd11274    321 VLKEINDRIKDRLQSCYRGEGTLDLAWLKVKDIPCSSALLTIDDNFCGLDMNAPLGVSEMVRGLPVFTEDRDRMTSVIAY 400

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217369006  439 VYKNHSLAFVGTKSGKLKKIRVDGPRGNALQYETVQVVDPGPVLRDMAFSKDHEQLYIMSERQLTRVPVESCG 511
Cdd:cd11274    401 VYKNHSLAFVGTKSGKLKKIRVDGTTKNALQYETVQVVDTGPILRDMAFSKDHEQLYIMSEKQLTRVPVESCG 473
Sema smart00630
semaphorin domain;
51-482 1.14e-75

semaphorin domain;


Pssm-ID: 214747 [Multi-domain]  Cd Length: 390  Bit Score: 256.91  E-value: 1.14e-75
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006    51 FNHLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHETGPDEDNPKCYPPRivqtCNEPLTTTNNVNK-MLLIDYKENRLIA 129
Cdd:smart00630    1 LQHLLLDEDNGTLYVGARNRLYQLSLNLILEAELKTGPVLSSPDCEECV----SKGKDPPTDCVNYiRLLLDYNEDRLLV 76

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006   130 CGS-LYQGICKLLRLEDLFklgepyhkkehylsgvnesgsvfgvivsysnlddklfIATAVD--GKPEYFPTISSRKLTK 206
Cdd:smart00630   77 CGTnAFQPVCRLRNLGELY-------------------------------------VGTVADfsGSDPAIPRSLSVRRLK 119

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006   207 NSeadgmfaYVFHDEFVASMIKIPSDtftiipdfdIYYVYGFSSGNFVYFLTLQPEMVsppgSTTKEQVYTSKLVRLCKE 286
Cdd:smart00630  120 GT-------SGVSLRTVLYDSKWLNE---------PNFVYAFESGDFVYFFFRETAVE----DDNCGKAVHSRVARVCKN 179

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006   287 DTA--------FNSYVEVPIGC---ERSGVEYRLLQAAYLSKAGAvlgrtlgvhPDDDLLFTVFSKGQkrkmKSLDESAL 355
Cdd:smart00630  180 DVGgprsldkkWTSFLKARLECsvpGEDPFYFNELQAAFLLPPGS---------ESDDVLYGVFSTSS----NPIPGSAV 246

                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006   356 CIFILKQINDRIKERLQSCYRGEGTLDL----AWLKVKDIPC-----SSALLTIDDNFCGLDMNAPLGVSDMVRGIPVFT 426
Cdd:smart00630  247 CAFSLSDINAVFNGPFKECETSTSQWLPysrgKVPYPRPGTCpnkppSSKDLPDETLNFIKSHPLMDEVVQPLTGRPLFV 326

                           410       420       430       440       450       460
                    ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217369006   427 E--DRDRMTSVIAYV---YKNHSLAFVGTKSGKLKKIRVDGPRGN--ALQYETVQVVDPG-PVL 482
Cdd:smart00630  327 KtdSNYLLTSIAVDRvatDGNYTVLFLGTSDGRILKVVLSESSSSseSVVLEEISVFPDGsPIS 390
IPT_plexin_repeat3 cd01181
Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1040-1140 8.47e-47

Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238586  Cd Length: 99  Bit Score: 162.59  E-value: 8.47e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006 1040 PTIVRIEPEWSIVSGNTPIAVWGTHLDLIQNPQIRAKHGGKEHINiCEVLNATEMTCQAPALALGPDHQsDLTERPEEFG 1119
Cdd:cd01181      1 PTITRIEPEWSFLSGGTPITVTGTNLNTVQEPRIRVKYGGVEKTS-CKVRNSTLMTCPAPSLALLNRSP-EPGERPVEFG 78

                           90       100
                   ....*....|....*....|.
gi 2217369006 1120 FILDNVQSLLILNKTNFTYYP 1140
Cdd:cd01181     79 LDGDNVQSLLILNRTSFSYYP 99
TIG_2 pfam18020
TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG ...
 708-802 1.12e-39

TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG domains have an Ig-like fold.


Pssm-ID: 465619  Cd Length: 94  Bit Score: 142.03  E-value: 1.12e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  708 DKILVPVEVIKPITLKAKNLPQPQSGQRGYECILNIQGSEQRVPALRFNSSSVQCQNTSYSYEGMeINNLPVELTVVWNG 787
Cdd:pfam18020    1 GSILVPVGVEREITLKARNLPLFQSGQLGYECVFEIEGATHVVPASRESSDSITCQEHQFSYSGS-SGELPATFYVTWNG 79

                           90
                   ....*....|....*
gi 2217369006  788 HFNIDNPAQNKVHLY 802
Cdd:pfam18020   80 GHRLDNPANLQVVLY 94
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 955-1038 2.32e-34

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 126.57  E-value: 2.32e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  955 TLSDLKPSRGPMSGGTQVTITGTNLNAGSNVVVMFGKQPCLFHRRSPSYIVCNTTSSDEVLEMKVSVQVDRAKIHQDLVF 1034
Cdd:cd01179      2 SITSLSPSYGPQSGGTRLTITGKHLNAGSSVRVTVGGQPCKILSVSSSQIVCLTPPSASPGEAPVKVLIDGARRLAPLVF 81


                   ....
gi 2217369006 1035 QYVE 1038
Cdd:cd01179     82 TYTE 85
Sema pfam01403
Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and ...
 310-488 4.16e-31

Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and Swiss:P51805


Pssm-ID: 460197 [Multi-domain]  Cd Length: 180  Bit Score: 120.84  E-value: 4.16e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  310 LQAAYLSKAGAVLGRtlgvhpdDDLLFTVFSKGQKrkmKSLDESALCIFILKQINDRIKERlqscYRGEGTLDLAWLKV- 388
Cdd:pfam01403    1 LQDVFVLKPGAGDAL-------DTVLYGVFTTQWS---NSIGGSAVCAFSLSDINAVFEGP----FKEQEKSDSKWLPYt 66

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  389 ------KDIPC--SSALLTIDDNFCGLDMNAPLGVS--DMVRGIPVFTEDRDRMTSVIAY----VYKNHSLAFVGTKSGK 454
Cdd:pfam01403   67 gkvpypRPGTCinDPLRLDLPDSVLNFVKDHPLMDEavQPVGGRPLLVRTGVRLTSIAVDrvqaLDGNYTVLFLGTDDGR 146

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 2217369006  455 LKKIrVDGPRGNALQYETVQVVDPG-PVLRDMAFS 488
Cdd:pfam01403  147 LHKV-VLVGSEESHIIEEIQVFPEPqPVLNLLLSS 180
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 858-953 1.44e-26

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 104.71  E-value: 1.44e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  858 PRITEIIPVTGPREGGTKVTIRGENLGLEFRDIASHVKVAGVECSPLVDGYIPAEQIVCEMGEAKPSQHAGFVEICVAVC 937
Cdd:cd01180      1 PVITEFFPLSGPLEGGTRLTICGSNLGLRKNDVRHGVRVGGVPCNPEPPEYSSSEKIVCTTGPAGNPVFNGPVEVTVGHG 80

                           90
                   ....*....|....*.
gi 2217369006  938 rpEFMARSSQLYYFMT 953
Cdd:cd01180     81 --SFRTESSEGFSFVD 94
TIG_plexin pfam17960
TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and ...
 564-654 7.13e-24

TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and Transcription factors) found in plexins.


Pssm-ID: 465588  Cd Length: 89  Bit Score: 96.95  E-value: 7.13e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  564 HPNNISVSQY-NVLLVLEtyNVPELSAGVNCTFEDLSEMDGLVVGNQIQCYSPAAKEVPRIiTENGDHHVVQLQLKSKET 642
Cdd:pfam17960    1 TPDNISRTTAtQLTLTVP--NLPALSEGYSCVFGDLTESPATVHDNGVKCATPPPSQLPPI-PTGQDHVTVKLSLRSSET 77

                           90
                   ....*....|..
gi 2217369006  643 GMTFASTSFVFY 654
Cdd:pfam17960   78 GVDFASTNFTFY 89
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
510-548 1.01e-13

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 66.80  E-value: 1.01e-13
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 2217369006   510 CGQYQSCGECLGSGDPHCGWCVLHNTCTRKERCERSKEP 548
Cdd:smart00423    2 CSKYTSCSECLLARDPYCAWCSSQGRCTSGERCDSRRQN 40
IPT smart00429
ig-like, plexins, transcription factors;
1039-1139 2.05e-13

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 67.06  E-value: 2.05e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  1039 DPTIVRIEPEWSIVSGNTPIAVWGTHLDLIQNPQIRAKHGGKEhiniCEVLN--ATEMTCQAPalalgPDHQSDLTERPE 1116
Cdd:smart00429    1 DPVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVGEAP----CTFSPssSTAIVCKTP-----PYHNIPGSVPVR 71

                            90       100
                    ....*....|....*....|...
gi 2217369006  1117 EFGFILDNVQSLlilnKTNFTYY 1139
Cdd:smart00429   72 TVGLRNGGVPSS----PQPFTYV 90
IPT smart00429
ig-like, plexins, transcription factors;
857-950 4.06e-13

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 66.29  E-value: 4.06e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006   857 NPRITEIIPVTGPREGGTKVTIRGENLGlEFRDIASHVKVAGVECSPLVDGyipAEQIVCEMGEAKPSQHAGFVEiCVAV 936
Cdd:smart00429    1 DPVITRISPTSGPVSGGTEITLCGKNLK-SISVVFVEVGVGEAPCTFSPSS---STAIVCKTPPYHNIPGSVPVR-TVGL 75

                            90
                    ....*....|....
gi 2217369006   937 CRPEFMARSSQLYY 950
Cdd:smart00429   76 RNGGVPSSPQPFTY 89
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 509-551 5.61e-13

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 64.65  E-value: 5.61e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 2217369006  509 SCGQYQSCGECLGSGDPHCGWCVLHNTCTRKERCERSKEPRRF 551
Cdd:pfam01437    1 RCSQYTSCSSCLAARDPYCGWCSSEGRCVRRSACGAPEGNCEE 43
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 954-1036 1.68e-12

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 64.39  E-value: 1.68e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  954 LTLSDLKPSRGPMSGGTQVTITGTNLNAGS-NVVVMFGKQPCLFHRRSPSYIVCNTTSSDEVLeMKVSVQV-DRAKIHQD 1031
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSsDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGL-VNVSVTVgGGGISSSP 79


                   ....*
gi 2217369006 1032 LVFQY 1036
Cdd:pfam01833   80 LTFTY 84
IPT smart00429
ig-like, plexins, transcription factors;
954-1037 1.55e-11

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 61.67  E-value: 1.55e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006   954 LTLSDLKPSRGPMSGGTQVTITGTNLNAGSNVVVMF--GKQPCLFHRRSPSYIVCNTTS-SDEVLEMKVS-VQVDRAKIH 1029
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVgvGEAPCTFSPSSSTAIVCKTPPyHNIPGSVPVRtVGLRNGGVP 81


                    ....*....
gi 2217369006  1030 -QDLVFQYV 1037
Cdd:smart00429   82 sSPQPFTYV 90
RasGAP_plexin_A cd12790
Ras-GTPase Activating Domain of type A plexins; Plexins form a conserved family of ...
 1311-1339 1.66e-11

Ras-GTPase Activating Domain of type A plexins; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. They are divided into four types (A-D) according to sequence similarity. In vertebrates, there are four type A plexins (A1-A4) that serve as the co-receptors for neuropilins to mediate the signaling of class 3 semaphorins except Sema3E, which signals through Plexin-D1. Plexins serve as direct receptors for several other members of the semaphorin family: class 1 and class 6 semaphorins signal through type A plexins, which mediate diverse biological functions including axon guidance, cardiovascular development, and immune function. Guanylyl cyclase Gyc76C and Off-track kinase (OTK), a putative receptor tyrosine kinase, modulate Sema1a and Plexin-A mediated axon repulsion. In their complex with Sema6s, type A plexins serve as signal-transducing subunits. An increasing number of molecules that interact with the intracellular region of Plexin-A have been identified; among them are IgCAMs (in axon guidance events) and Trem2-DAP12 (in immune responses). Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213350 [Multi-domain]  Cd Length: 385  Bit Score: 67.83  E-value: 1.66e-11
                           10        20
                   ....*....|....*....|....*....
gi 2217369006 1311 GIPFLDYRTYTMRVLFPGIEDHPVLRDLE 1339
Cdd:cd12790      1 GIPFLDYRTYAMRVLFPGIEDHPVLRELE 29
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 858-937 1.06e-10

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 59.38  E-value: 1.06e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  858 PRITEIIPVTGPREGGTKVTIRGENLGLEFRDIasHVKVAGVECSPLvdgYIPAEQIVCEMgeakPSQHAGFVEICVAVC 937
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDL--KVTIGGTPCTVI---SVSSTTIVCTT----PPGTSGLVNVSVTVG 71
Plexin_cytopl pfam08337
Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various ...
 1311-1343 2.57e-09

Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various plexins. Plexins are receptors for semaphorins, and plexin signalling is important in path finding and patterning of both neurons and developing blood vessels. The cytoplasmic region, which has been called a SEX domain in some members of this family, is involved in downstream signalling pathways, by interaction with proteins such as Rac1, RhoD, Rnd1 and other plexins. This domain acts as a RasGAP domain.


Pssm-ID: 462434 [Multi-domain]  Cd Length: 500  Bit Score: 61.44  E-value: 2.57e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 2217369006 1311 GIPFLDYRTYTMRVLFPGIEDHPVLRDLEASVL 1343
Cdd:pfam08337    1 GIPFLDYRTYAMRVLFPGVEDHPLLVLLDVPVT 33
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 804-856 3.09e-08

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 51.17  E-value: 3.09e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2217369006  804 CGAMReSCGLCLKADpDFACGWCQGPGQCTLRQHCPAQESQWLELSGAKSKCT 856
Cdd:pfam01437    2 CSQYT-SCSSCLAAR-DPYCGWCSSEGRCVRRSACGAPEGNCEEWEQASSKCP 52
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 655-702 1.05e-07

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 49.63  E-value: 1.05e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2217369006  655 NCSVHNSCLSCVESP-YRCHWCKYRHVCTHdPKTCSFQEGR----VKLPEDCP 702
Cdd:pfam01437    1 RCSQYTSCSSCLAARdPYCGWCSSEGRCVR-RSACGAPEGNceewEQASSKCP 52
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
655-702 1.07e-06

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 46.77  E-value: 1.07e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 2217369006   655 NCSVHNSCLSCVESPY-RCHWCKYRHVCTHDPkTCSFQEGRVkLPEDCP 702
Cdd:smart00423    1 RCSKYTSCSECLLARDpYCAWCSSQGRCTSGE-RCDSRRQNW-LSGGCP 47
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1142-1222 1.32e-06

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 47.83  E-value: 1.32e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006 1142 PVFEAFGPS-GILElkPGTPIILKGKNLippvagGNVKLNYTVLVGEKPCTVT-VSDVQLLCESP--NLIGRHKVMARVG 1217
Cdd:cd00603      1 PVITSISPSsGPLS--GGTRLTITGSNL------GSGSPRVRVTVGGVPCKVLnVSSTEIVCRTPaaATPGEGPVEVTVD 72


                   ....*
gi 2217369006 1218 GMEYS 1222
Cdd:cd00603     73 GANVS 77
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
806-849 1.70e-06

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 46.00  E-value: 1.70e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 2217369006   806 AMRESCGLCLKAdPDFACGWCQGPGQCTLRQHCPAQESQWLELS 849
Cdd:smart00423    3 SKYTSCSECLLA-RDPYCAWCSSQGRCTSGERCDSRRQNWLSGG 45
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1142-1226 2.85e-05

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 43.97  E-value: 2.85e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006 1142 PVFEAFGPSGIlELKPGTPIILKGKNLippvagGNVKLNYTVLVGEKPCTV-TVSDVQLLCESPNL-IGRHKVMARVGGM 1219
Cdd:pfam01833    1 PVITSISPSSG-PASGGTTITITGSNF------GTDSSDLKVTIGGTPCTViSVSSTTIVCTTPPGtSGLVNVSVTVGGG 73


                   ....*..
gi 2217369006 1220 EYSPGMV 1226
Cdd:pfam01833   74 GISSSPL 80
IPT smart00429
ig-like, plexins, transcription factors;
1141-1204 3.42e-04

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 40.87  E-value: 3.42e-04
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217369006  1141 NPVFEAFGP-SGILElkPGTPIILKGKNLIPpvaGGNVKlnYTVLVGEKPCTVT-VSDVQLLCESP 1204
Cdd:smart00429    1 DPVITRISPtSGPVS--GGTEITLCGKNLKS---ISVVF--VEVGVGEAPCTFSpSSSTAIVCKTP 59
 
Name Accession Description Interval E-value
Sema_plexin_A4 cd11274
The Sema domain, a protein interacting module, of Plexin A4; Plexin A4 forms a receptor ...
 39-511 0e+00

The Sema domain, a protein interacting module, of Plexin A4; Plexin A4 forms a receptor complex with neuropilins (NRPs) and transduces signals for class 3 semaphorins in the nervous system. It regulates facial nerve development by functioning as a receptor for Sema3A/NRP1. Both plexins A3 and A4 are essential for normal sympathetic development. They function both cooperatively, to regulate the migration of sympathetic neurons, and differentially, to guide sympathetic axons. Plexin A4 is also expressed in lymphoid tissues and functions in the immune system. It negatively regulates T lymphocyte responses. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200535 [Multi-domain]  Cd Length: 473  Bit Score: 1051.85  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006   39 SFVTFRGEPAEGFNHLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHETGPDEDNPKCYPPRIVQTCNEPLTTTNNVNKML 118
Cdd:cd11274      1 FITFTGDQTEWTFNHLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHQTGPDEDNPKCYPPRIVQTCNEPLTLTNNINKML 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  119 LIDYKENRLIACGSLYQGICKLLRLEDLFKLGEPYHKKEHYLSGVNESGSVFGVIVSYSNLDDKLFIATAVDGKPEYFPT 198
Cdd:cd11274     81 LIDYKENRLIACGSLYQGICKLLRLDDLFKLGEPFHKKEHYLSGVNESGSVFGVIVSYSNLDDKLFIATAVDGKPEYFPT 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  199 ISSRKLTKNSEADGMFAYVFHDEFVASMIKIPSDTFTIIPDFDIYYVYGFSSGNFVYFLTLQPEMVSPPGSTTKEQVYTS 278
Cdd:cd11274    161 ISSRKLTKNSEADGMFAYVFHDEFVASMIKIPSDTFTIIPDFDIYYIYGFSSGNFVYFLTLQPEMISPPGSTTKEQVYTS 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  279 KLVRLCKEDTAFNSYVEVPIGCERSGVEYRLLQAAYLSKAGAVLGRTLGVHPDDDLLFTVFSKGQKRKMKSLDESALCIF 358
Cdd:cd11274    241 KLVRLCKEDTAFNSYVEVPIGCEKNGVEYRLLQAAYLSKAGAILARSLGVGPDDDILFTVFSKGQKRKMKSLDESALCIF 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  359 ILKQINDRIKERLQSCYRGEGTLDLAWLKVKDIPCSSALLTIDDNFCGLDMNAPLGVSDMVRGIPVFTEDRDRMTSVIAY 438
Cdd:cd11274    321 VLKEINDRIKDRLQSCYRGEGTLDLAWLKVKDIPCSSALLTIDDNFCGLDMNAPLGVSEMVRGLPVFTEDRDRMTSVIAY 400

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217369006  439 VYKNHSLAFVGTKSGKLKKIRVDGPRGNALQYETVQVVDPGPVLRDMAFSKDHEQLYIMSERQLTRVPVESCG 511
Cdd:cd11274    401 VYKNHSLAFVGTKSGKLKKIRVDGTTKNALQYETVQVVDTGPILRDMAFSKDHEQLYIMSEKQLTRVPVESCG 473
Sema_plexin_A cd11244
The Sema domain, a protein interacting module, of Plexin A; Plexins serve as receptors of ...
 40-508 0e+00

The Sema domain, a protein interacting module, of Plexin A; Plexins serve as receptors of semaphorins and may be the ancestor of semaphorins. Members of the Plexin A subfamily are receptors for Sema1s, Sema3s, and Sema6s, and they mediate diverse biological functions including axon guidance, cardiovascular development, and immune function. Guanylyl cyclase Gyc76C and Off-track kinase (OTK), a putative receptor tyrosine kinase, modulate Sema1a-Plexin A mediated axon repulsion. Sema3s do not interact directly with plexin A receptors, but instead bind Neuropilin-1 or Neuropilin-2 toactivate neuropilin-plexin A holoreceptor complexes. In contrast to Sema3s, Sema6s do not require neuropilins for plexin A binding. In the complex, plexin As serve as signal-transducing subunits. An increasing number of molecules that interact with the intracellular region of Plexin A have been identified; among them are IgCAMs (in axon guidance events) and Trem2-DAP12 (in immune responses). The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200505 [Multi-domain]  Cd Length: 470  Bit Score: 930.77  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006   40 FVTFRGEP-AEGFNHLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHETGPDEDNPKCYPPRIVQTCNEPLTTTNNVNKML 118
Cdd:cd11244      1 FVTFRGEPrDWSFNHLTVHRRTGEVYVGAINRVYKLSSNLTVLVTHETGPVEDNPKCYPPPIVQTCNEPLTTTNNVNKLL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  119 LIDYKENRLIACGSLYQGICKLLRLEDLFKLGEPYHKKEHYLSGVNESGSVFGVIVSYSNLDDKLFIATAVDGKPEYFPT 198
Cdd:cd11244     81 LIDYSENRLIACGSLYQGVCKLLRLEDLFKLGEPHHKKEHYLSGVNESGTMFGVIVSYSNGDDKLFIGTAVDGKSEYFPT 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  199 ISSRKLTKNSEADGMFAYVFHDEFVASMIKIPSDTFTIIPDFDIYYVYGFSSGNFVYFLTLQPEMVSPPGSTTKEQVYTS 278
Cdd:cd11244    161 LSSRKLTADEESDGMFAYVYHDEFVSSQIKIPSDTLSIIPDFDIYYVYGFSSGNFVYFLTLQPETQLTPGDSTGEQFYTS 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  279 KLVRLCKEDTAFNSYVEVPIGCERSGVEYRLLQAAYLSKAGAVLGRTLGVHPDDDLLFTVFSKGQKRKMKSLDESALCIF 358
Cdd:cd11244    241 KIVRLCKDDTKFYSYVEFPIGCTRDGVEYRLLQAAYLSKPGKALAQALGISEDEDVLFTIFSKGQKNRMKPPDESALCLF 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  359 ILKQINDRIKERLQSCYRGEGTLDLAWLKVKDIPCSSALLTIDDNFCGLDMNAPLGVSDMVRGIPVFTEDRDRMTSVIAY 438
Cdd:cd11244    321 TLKQINLRIKERLQSCYRGEGKLSLPWLLNKDLPCINAPLQIDDNFCGLDMNQPLGGSDMVEGIPLFTDDRDRMTSVAAY 400

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  439 VYKNHSLAFVGTKSGKLKKIRVDGPRGNALQYETVQVVDPGPVLRDMAFSKDHEQLYIMSERQLTRVPVE 508
Cdd:cd11244    401 VYKGHSVVFVGTKSGKLKKIRVDGPPHNALQYETVQVVEGSPILRDMAFSPDHQYLYIMSERQVTRVPVE 470
Sema_plexin_A2 cd11272
The Sema domain, a protein interacting module, of Plexin A2; Plexin A2 serves as a receptor ...
 40-551 0e+00

The Sema domain, a protein interacting module, of Plexin A2; Plexin A2 serves as a receptor for class 6 semaphorins. Interactions between Plexin A2, A4 and semaphorins 6A and 6B control the lamina-restricted projection of hippocampal mossy fibers. Sema6B also repels the growth of mossy fibers in a Plexin A4 dependent manner. Plexin A2 does not suppress Sema6B function. In addition, studies have shown that Plexin A2 may be related to anxiety and other psychiatric disorders. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200533 [Multi-domain]  Cd Length: 515  Bit Score: 772.56  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006   40 FVTFRGEPAE-GFNHLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHETGPDEDNPKCYPPRIVQTCNEPLTTTNNVNKML 118
Cdd:cd11272      1 FNTFHSENRDwTFNHLTVHQSTGAVYVGAINRVYKLSGNLTILVAHKTGPEEDNKSCYPPLIVQPCSEVLTLTNNVNKLL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  119 LIDYKENRLIACGSLYQGICKLLRLEDLFKLGEPYHKKEHYLSGVNESGSVFGVIVSYSNLDDKLFIATAVDGKPEYFPT 198
Cdd:cd11272     81 IIDYSENRLLACGSLYQGVCKLLRLDDLFILVEPSHKKEHYLSSVNKTGTMYGVIVRSEGEDGKLFIGTAVDGKQDYFPT 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  199 ISSRKLTKNSEADGMFAYVFHDEFVASMIKIPSDTFTIIPDFDIYYVYGFSSGNFVYFLTLQPEmvSPPG---STTKEQV 275
Cdd:cd11272    161 LSSRKLPRDPESSAMLDYELHSDFVSSLIKIPSDTLALVSHFDIFYIYGFASGNFVYFLTVQPE--TPEGvsiNSAGDLF 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  276 YTSKLVRLCKEDTAFNSYVEVPIGCERSGVEYRLLQAAYLSKAGAVLGRTLGVHPDDDLLFTVFSKGQKRKMKSLDESAL 355
Cdd:cd11272    239 YTSRIVRLCKDDPKFHSYVSLPFGCVRGGVEYRLLQAAYLSKPGEVLARSLNITAQEDVLFAIFSKGQKQYHHPPDDSAL 318

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  356 CIFILKQINDRIKERLQSCYRGEGTLDLAWLKVKDIPCSSALLTIDDNFCGLDMNAPLGVSDMVRGIPVFTEDRDRMTSV 435
Cdd:cd11272    319 CAFPIRAINAQIKERLQSCYQGEGNLELNWLLGKDVQCTKAPVPIDDNFCGLDINQPLGGSTPVEGVTLYTSSRDRLTSV 398

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  436 IAYVYKNHSLAFVGTKSGKLKKIRVDGPRGNALQYETVQVV-DPGPVLRDMAFSKDHEQLYIMSERQLTRVPVESCGQYQ 514
Cdd:cd11272    399 ASYVYNGYSVVFVGTKSGKLKKIRADGPPHGGVQYEMVSVFkDGSPILRDMAFSIDHKYLYVMSERQVSRVPVESCEQYT 478

                          490       500       510
                   ....*....|....*....|....*....|....*..
gi 2217369006  515 SCGECLGSGDPHCGWCVLHNTCTRKERCERSKEPRRF 551
Cdd:cd11272    479 TCGECLSSGDPHCGWCALHNMCSRRDKCQRAWEPFRF 515
Sema_plexin_A1 cd11271
The Sema domain, a protein interacting module, of Plexin A1; Plexin A1 is found in both the ...
 37-508 0e+00

The Sema domain, a protein interacting module, of Plexin A1; Plexin A1 is found in both the nervous and immune systems. Its external Sema domain is also shared by semaphorin proteins. In the nervous system, Plexin A1 mediates Sema3A axon guidance function by interacting with the Sema3A coreceptor neuropilin, resulting in actin depolarization and cell repulsion. In the immune system, Plexin A1 mediates Sema6D signaling by binding to the Sema6D-Trem2-DAP12 complex on immune cells and osteoclasts to promote Rac activation and DAP12 phosphorylation. In gene profiling experiments, Plexin A1 was identified as a CIITA (class II transactivator) regulated gene in primary dendritic cells (DCs). The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200532 [Multi-domain]  Cd Length: 474  Bit Score: 624.30  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006   37 QRSFVTFRGePAEGFNHLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHETGPDEDNPKCYPPRIVQTCNEPLTTTNNVNK 116
Cdd:cd11271      1 QPPFRTFTA-SDWSLTHLVVHNKTGEVYVGAVNRIYKLSNNLTLLRTHVTGPVEDNEKCYPPPSVQSCPHGLGTTNNVNK 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  117 MLLIDYKENRLIACGSLYQGICKLLRLEDLFKLGEPYHKKEHYLSGVNESGSVFGVIVSYSNLDDKLFIATAVDGKPEYF 196
Cdd:cd11271     80 LLLVDYAANRLIACGSASQGICQFLRLDDLFKLGEPHHRKEHYLSSVNESGTMSGVIIEVGNGQNKLFVGTPIDGKSEYF 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  197 PTISSRKLTKNSEADGMFAYVFHDEFVASMIKIPSDTFTIIPDFDIYYVYGFSSGNFVYFLTLQ--PEMVSPpgSTTKEQ 274
Cdd:cd11271    160 PTLSSRKLMANEENAEMFGFVYQDEFVSSQLKIPSDTLSKFPTFDIYYVYSFSSEQFVYYLTLQldTQLTSP--DSTGEQ 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  275 VYTSKLVRLCKEDTAFNSYVEVPIGCERSGVEYRLLQAAYLSKAGAVLGRTLGVHPDDDLLFTVFSKGQKRKMKSLDESA 354
Cdd:cd11271    238 FFTSKIVRLCVDDPKFYSYVEFPIGCEQDGVEYRLIQDAYLSKPGKALAKQLGISEREDILFTVFSQGQKNRVKPPKESV 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  355 LCIFILKQINDRIKERLQSCYRGEGTLDLAWLKVKDIPCSSALLTIDDNFCGLDMNAPLGVSDMVRGIPVFTEDRDRMTS 434
Cdd:cd11271    318 LCLFTLKKIKDKIKERIQSCYRGEGKLSLPWLLNKELGCINSPLQIDDNFCGQDFNQPLGGTVTIEGTPLFVDKEDGMTS 397

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217369006  435 VIAYVYKNHSLAFVGTKSGKLKKIRVD--GPRGN-ALQYETVQVVDPGPVLRDMAFSKDHEQLYIMSERQLTRVPVE 508
Cdd:cd11271    398 VAAYDYRGRTVVFAGTRSGRIKKILVDlsAPSSRpALQYENVVAHEGSPILRDLVLSPDRQYIYAMTEKQVTRVPVE 474
Sema_plexin_A3 cd11273
The Sema domain, a protein interacting module, of Plexin A3; Plexin-A3 forms a receptor ...
 53-508 0e+00

The Sema domain, a protein interacting module, of Plexin A3; Plexin-A3 forms a receptor complex with neuropilin-2 and transduces signals for class 3 semaphorins in the nervous system. Both plexins A3 and A4 are essential for normal sympathetic neuron development. They function cooperatively to regulate the migration of sympathetic neurons, and differentially to guide sympathetic axons. Both plexins A3 and A4 are not required for guiding neural crest precursors prior to reaching the sympathetic anlagen. Plexin A3 is a major driving force for intraspinal motor growth cone guidance. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200534 [Multi-domain]  Cd Length: 469  Bit Score: 616.56  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006   53 HLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHETGPDEDNPKCYPPRIVQTCNEPLTTTNNVNKMLLIDYKENRLIACGS 132
Cdd:cd11273     15 HLAVHRVTGEVFVGAVNRVYKLSANLTELRAHVTGPVEDNARCYPPPSVRVCAHRLAPVDNVNKLLLVDYAGNRLVACGS 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  133 LYQGICKLLRLEDLFKLGEPYHKKEHYLSGVNESGSVFGVIVSYSNLDDKLFIATAVDGKPEYFPTISSRKLTKNSEADG 212
Cdd:cd11273     95 IWQGVCQFLRLEDLFKLGEPHHRKEHYLSGAQEPDSMAGVIVEQGKGPSKLFVGTAIDGKSEYFPTLSSRKLISDEDSAD 174

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  213 MFAYVFHDEFVASMIKIPSDTFTIIPDFDIYYVYGFSSGNFVYFLTLQPEMVSPPGSTTKEQVYTSKLVRLCKEDTAFNS 292
Cdd:cd11273    175 MFSLVYQDEFVSSQIKIPSDTLSLYPAFDIYYVYGFVSASFVYFLTLQLDTQQTLLDTAGEKFFTSKIVRMCANDTEFYS 254

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  293 YVEVPIGCERSGVEYRLLQAAYLSKAGAVLGRTLGVHPDDDLLFTVFSKGQKRKMKSLDESALCIFILKQINDRIKERLQ 372
Cdd:cd11273    255 YVEFPLGCSKDGVEYRLVQAAHLAKPGLLLAQALGVPEDEDVLFTIFSQGQKNRASPPRETILCLFTLSNINAHIRERIQ 334

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  373 SCYRGEGTLDLAWLKVKDIPCSSALLTIDDNFCGLDMNAPLGVSDMVRGIPVFTEDRDRMTSVIAYVYKNHSLAFVGTKS 452
Cdd:cd11273    335 SCYRGEGTLSLPWLLNKELPCINTPMQINGNFCGLVLNQPLGGLHVIEGLPLLADSTDGMASVAAYTYRQHSVVFIGTRS 414

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2217369006  453 GKLKKIRVDGPRgNALQYETVQVVDPGPVLRDMAFSKDHEQLYIMSERQLTRVPVE 508
Cdd:cd11273    415 GSLKKVRVDGFQ-DAHLYETVPVVDGSPILRDMVFSPDHRYIYLLSEKQVSQLPVE 469
Sema_plexin_like cd11236
The Sema domain, a protein interacting module, of Plexins and MET-like receptor tyrosine ...
 51-508 3.28e-126

The Sema domain, a protein interacting module, of Plexins and MET-like receptor tyrosine kinases; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestor of semaphorins. Ligand binding activates signal transduction pathways controlling axon guidance in the nervous system and other developmental processes including cell migration and morphogenesis, immune function, and tumor progression. Plexins are divided into four types (A-D) according to sequence similarity. In vertebrates, type A Plexins serve as the co-receptors for neuropilins to mediate the signalling of class 3 semaphorins except Sema3E, which signals through Plexin D1. Plexins serve as direct receptors for several other members of the semaphorin family: class 6 semaphorins signal through type A plexins and class 4 semaphorins through type B. Plexin C1 serves as the receptor of Sema7A and plays regulation roles in both immune and nervous systems. This family also includes the Met and RON receptor tyrosine kinases. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200497 [Multi-domain]  Cd Length: 401  Bit Score: 397.47  E-value: 3.28e-126
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006   51 FNHLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHETGPDEDNPKCYPPRiVQTCNEPLTTTNNVNKMLLIDYKENRLIAC 130
Cdd:cd11236      2 FNHLAVDNSTGRVYVGAVNRLYQLDSSLLLEAEVSTGPVLDSPLCLPPG-CCSCDHPRSPTDNYNKILLIDYSSGRLITC 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  131 GSLYQGICKLLRLEDLFKLGEPYHkkeHYLSGVNESGSVFGVI-VSYSNLDDKLFIATAVDGK--PEYFPTISSRKLtkn 207
Cdd:cd11236     81 GSLYQGVCQLRNLSNISVVVERSS---TPVAANDPNASTVGFVgPGPYNNENVLYVGATYTNNgyRDYRPAVSSRSL--- 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  208 sEADGMFAyvFHDEFVASMIKIPSDTftiIPDFDIYYVYGFSSGNFVYFLTLQPEmvsppgSTTKEQVYTSKLVRLCKED 287
Cdd:cd11236    155 -PPDDDFN--AGSLTGGSAISIDDEY---RDRYSIKYVYGFSSGGFSYFVTVQRK------SVDDESPYISRLVRVCQSD 222

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  288 TAFNSYVEVPIGCE-RSGVEYRLLQAAYLSKAGAVLGRTLGVHPDDDLLFTVFSKGQKRKMKSLDESALCIFILKQINDR 366
Cdd:cd11236    223 SNYYSYTEVPLQCTgGDGTNYNLLQAAYVGKAGSDLARSLGISTDDDVLFGVFSKSKGPSAEPSSKSALCVFSMKDIEAA 302

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  367 IKErlqscyrgegtldlawlkvkdipcssalltiddnfcgldmNAPLGVSDMVRGIPVFteDRDRMTSVIAYVYKNHSLA 446
Cdd:cd11236    303 FND----------------------------------------NCPLGGGVPITTSAVL--SDSLLTSVAVTTTRNHTVA 340

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217369006  447 FVGTKSGKLKKIRVDGPRgNALQYETVQVVDPGPVLRDMAFSKDHEQLYIMSERQLTRVPVE 508
Cdd:cd11236    341 FLGTSDGQLKKVVLESSS-SATQYETLLVDSGSPILPDMVFDPDGEHLYVMTPKKVTKVPVE 401
Sema_plexin_B2 cd11276
The Sema domain, a protein interacting module, of Plexin B2; Plexin B2 serves as the receptor ...
 52-508 1.56e-81

The Sema domain, a protein interacting module, of Plexin B2; Plexin B2 serves as the receptor of Sema4C and Sema4G. By signaling the effect of Sema4C and Sema4G, the plexin B2 receptor plays important roles in neural tube closure and cerebellar granule cell development. Mice lacking Plexin B2 demonstrated defects in closure of the neural tube and disorganization of the embryonic brain. In developing kidney, Sema4C-Plexin B2 signaling modulates ureteric branching. Plexin B2 is expressed both in the pretubular aggregates and the ureteric epithelium in the developing kidney. Deletion of Plexin B2 results in renal hypoplasia and occasional double ureters. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200537 [Multi-domain]  Cd Length: 449  Bit Score: 275.89  E-value: 1.56e-81
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006   52 NHLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHETGPDEDNPKCYPPRIVQTCNEpLTTTNNVNKMLLIDYKENRLIACG 131
Cdd:cd11276      9 NHLVVDPQTGRVYLGAVNALYQLDADLQLESRVETGPKKDNKKCTPPIEENQCTE-AKMTDNYNKLLLLDSANKTLVVCG 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  132 SLYQGICKLLRLEDLFKL-------GEpyhkkEHYLSGVNESGSVFGVIVSYSNLDDKLFIATAVDGKPEYFPTISSRKL 204
Cdd:cd11276     88 SLFKGICSLRNLSNISEViyysdtsGE-----KSFVASNDEGVSTVGLISSLKPGNDRVFFVGKGNGSNDNGKIISTRLL 162

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  205 TKNSEADgmfayVFHDEFVASMIKIPsdtftIIPDFDIYYVYGFSSGNFVYFLTLQpemvsPPGSTTKEQVYtskLVRLC 284
Cdd:cd11276    163 QNYDDRE-----VFENYIDAATVKSA-----YVSRYTQQFRYAFEDNNYVYFLFNQ-----QLGHPDKNRTL---IARLC 224

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  285 KEDTAFNSYVEVPIGCERSGVEYRLLQAAYLSKAGAVLGRTLG-VHPDDDLLFTVFSkgqkRKMKSLDESALCIFILKQI 363
Cdd:cd11276    225 ENDHHYYSYTEMDLNCRDGANAYNKCQAAYVSTPGKELAQNYGnSILSDKVLFAVFS----RDEKDSGESALCMFPLKSI 300

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  364 NDRIKERLQSCYRGE----GTLDLAWLKVKDIPCSSALLTIDDNF-CGLD-MNAPLGVSDMVRG-IPVFTEDRDRMTSVI 436
Cdd:cd11276    301 NAKMEANREACYTGTiddrDVFYKPFHSQKDIICGSHQQKNSKSFpCGSEhLPYPLGSRDELALtAPVLQRGGLNLTAVT 380

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217369006  437 AYVYKNHSLAFVGTKSGKLKKIRVDGPrgnALQYETVQVVDPGPVLRDMAFSKDHEQLYIMSERQLTRVPVE 508
Cdd:cd11276    381 VAVENGHTVAFLGTSDGRILKVHLSPD---PEEYNSILIEKNKPVNKDLVLDKTLEHLYIMTEDKVFRLPVQ 449
Sema smart00630
semaphorin domain;
51-482 1.14e-75

semaphorin domain;


Pssm-ID: 214747 [Multi-domain]  Cd Length: 390  Bit Score: 256.91  E-value: 1.14e-75
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006    51 FNHLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHETGPDEDNPKCYPPRivqtCNEPLTTTNNVNK-MLLIDYKENRLIA 129
Cdd:smart00630    1 LQHLLLDEDNGTLYVGARNRLYQLSLNLILEAELKTGPVLSSPDCEECV----SKGKDPPTDCVNYiRLLLDYNEDRLLV 76

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006   130 CGS-LYQGICKLLRLEDLFklgepyhkkehylsgvnesgsvfgvivsysnlddklfIATAVD--GKPEYFPTISSRKLTK 206
Cdd:smart00630   77 CGTnAFQPVCRLRNLGELY-------------------------------------VGTVADfsGSDPAIPRSLSVRRLK 119

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006   207 NSeadgmfaYVFHDEFVASMIKIPSDtftiipdfdIYYVYGFSSGNFVYFLTLQPEMVsppgSTTKEQVYTSKLVRLCKE 286
Cdd:smart00630  120 GT-------SGVSLRTVLYDSKWLNE---------PNFVYAFESGDFVYFFFRETAVE----DDNCGKAVHSRVARVCKN 179

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006   287 DTA--------FNSYVEVPIGC---ERSGVEYRLLQAAYLSKAGAvlgrtlgvhPDDDLLFTVFSKGQkrkmKSLDESAL 355
Cdd:smart00630  180 DVGgprsldkkWTSFLKARLECsvpGEDPFYFNELQAAFLLPPGS---------ESDDVLYGVFSTSS----NPIPGSAV 246

                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006   356 CIFILKQINDRIKERLQSCYRGEGTLDL----AWLKVKDIPC-----SSALLTIDDNFCGLDMNAPLGVSDMVRGIPVFT 426
Cdd:smart00630  247 CAFSLSDINAVFNGPFKECETSTSQWLPysrgKVPYPRPGTCpnkppSSKDLPDETLNFIKSHPLMDEVVQPLTGRPLFV 326

                           410       420       430       440       450       460
                    ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217369006   427 E--DRDRMTSVIAYV---YKNHSLAFVGTKSGKLKKIRVDGPRGN--ALQYETVQVVDPG-PVL 482
Cdd:smart00630  327 KtdSNYLLTSIAVDRvatDGNYTVLFLGTSDGRILKVVLSESSSSseSVVLEEISVFPDGsPIS 390
Sema_plexin_B cd11245
The Sema domain, a protein interacting module, of Plexin B; Plexins, which contain semaphorin ...
 51-508 1.34e-70

The Sema domain, a protein interacting module, of Plexin B; Plexins, which contain semaphorin domains, function as receptors of semaphorins and may be the ancestors of semaphorins. There are three members of the Plexin B subfamily, namely B1, B2 and B3. Plexins B1, B2 and B3 are receptors for Sema4D, Sema4C and Sema4G, and Sema5A, respectively. The activation of plexin B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. By signaling the effect of Sema4C and Sema4G, the plexin B2 receptor is critically involved in neural tube closure and cerebellar granule cell development. Plexin B3, the receptor of Sema5A, is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin B3 has been linked to verbal performance and white matter volume in human brain. Small GTPases play important roles in plexin B signaling. Plexin B1 activates Rho through Rho-specific guanine nucleotide exchange factors, leading to neurite retraction. Plexin B1 possesses an intrinsic GTPase-activating protein activity for R-Ras and induces growth cone collapse through R-Ras inactivation. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200506 [Multi-domain]  Cd Length: 440  Bit Score: 244.07  E-value: 1.34e-70
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006   51 FNHLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHETGPDEDNPKCYPPRIVQTCNEPlTTTNNVNKMLLIDYKENRLIAC 130
Cdd:cd11245      2 INHLAQDPQTGRLYLGAVNGLFQLSPNLQLESRADTGPKKDSPQCLPPITAAECPQA-KETDNFNKLLLVNSANGTLVVC 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  131 GSLYQGICKLLRLEDLFK-LGEPYHKKE-HYLSGVNESGSVFGVIVSYSNLDDKLFIATAVDGK-PEYFPTISSRKLTKN 207
Cdd:cd11245     81 GSLFQGVCELRNLNSVNKpLYRPETPGDkQYVAANEPSVSTVGLISYFKDGLSLLFVGRGYTSSlSGGIPPITTRLLQEH 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  208 SEADgmfayVFHDEFVASMIKipsdtfTIIPDFDIYYVYGFSSGNFVYFLTLQpemvSPPGSTTKEQVYTSklvRLCKED 287
Cdd:cd11245    161 GEMD-----AFSNEVEAKLVV------GSASRYHHDFVYAFADNGYIYFLFSR----RPGTADSTKRTYIS---RLCEND 222

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  288 TAFNSYVEVPIGCE-RSGVEYRLLQAAYLSKAGAVLgrtlgvhpDDDLLFTVFSKGQKRKMKSLDESALCIFILKQINDR 366
Cdd:cd11245    223 HHYYSYVELPLNCTvNQENTYNLVQAAYLAKPGKVL--------NGKVLFGVFSADEASTAAPDGRSALCMYPLSSVDAR 294

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  367 IKERLQSCYRGEGTLD----LAWLK--VKDIPCSSALLTIDDNFCGLD-MNAPLGVSDMVRGIPVFTEDrDRMTSVIAYV 439
Cdd:cd11245    295 FERTRESCYTGEGLEDdkpeTAYIEynVKSICKTLPDKNVKAYPCGAEhTPSPLASRYPLAAKPILTRN-DMLTAVAVAV 373

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217369006  440 YKNHSLAFVGTKSGKLKKIRVDGprGNALQYETVQVVDPGPVLRDMAFSKDHEQLYIMSERQLTRVPVE 508
Cdd:cd11245    374 ENGHTIAFLGDSGGQLHKVYLDP--NHTDFYSTIPGDQDSAVNKDLLFDSTLNHLYVMTGKKISKVPVQ 440
Sema cd09295
The Sema domain, a protein interacting module, of semaphorins and plexins; Both semaphorins ...
 51-508 3.71e-65

The Sema domain, a protein interacting module, of semaphorins and plexins; Both semaphorins and plexins have a Sema domain on their N-termini. Plexins function as receptors for the semaphorins. Evolutionarily, plexins may be the ancestor of semaphorins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems, and cancer. Semaphorins can be divided into 7 classes. Vertebrates have members in classes 3-7, whereas classes 1 and 2 are known only in invertebrates. Class 2 and 3 semaphorins are secreted; classes 1 and 4 through 6 are transmembrane proteins; and class 7 is membrane associated via glycosylphosphatidylinositol (GPI) linkage. Plexins are a large family of transmembrane proteins, which are divided into four types (A-D) according to sequence similarity. In vertebrates, type A plexins serve as co-receptors for neuropilins to mediate the signalling of class 3 semaphorins. Plexins serve as direct receptors for several other members of the semaphorin family: class 6 semaphorins signal through type A plexins and class 4 semaphorins through type B plexins. This family also includes the MET and RON receptor tyrosine kinases. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves to recognize and bind receptors.


Pssm-ID: 200495 [Multi-domain]  Cd Length: 392  Bit Score: 226.70  E-value: 3.71e-65
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006   51 FNHLVVDERTGHIYLGAVNRIYKLSSDLKVL------VTHETGPDEDNPKCYPPrivqtCNEPLTTTNNVNKMLLIDYKE 124
Cdd:cd09295      2 DDKILVSFRKDTIYVGAIARIYKVDGGGTRLllscisPELNFGFNEDQKAFCPL-----RRGKWTECINYIKVLQQKGDL 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  125 NRLIACGSLY-QGICKLLRLEDLFKLGEPYHKKEHYLSGVNESGSVFGVIVsysnlDDKLFIATAVDGKPEYFPTISSRK 203
Cdd:cd09295     77 DILAVCGSNAaQPSCGSYRLDVLVELGKVRWPSGRPRCPIDNKHSNMGVNV-----DSKLYSATDHDFKDGDRPALSRRS 151

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  204 LTKNSeadgmfayvfhdefvaSMIKIPSDTFTiipdFDIYYVYGFSSG---NFVYFLTLQPemvsPPGSTTKEQVYTSKL 280
Cdd:cd09295    152 SNVHY----------------LRIVVDSSTGL----DEITFVYAFVSGdddDEVYFFFRQE----PVEYLKKGMVYVPRI 207

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  281 VRLCKEDTA--------FNSYVEVPIGCER--SGVEYRLLQAAYLSKAGAvlgrtlgvhpDDDLLFTVFSKGQkrkmKSL 350
Cdd:cd09295    208 ARVCKLDVGgchrlkkkLTSFLKADLNCSRpqSGFAFNLLQDATGDTKNL----------IQDVKFAIFSSCL----NKS 273

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  351 DESALCIFILKQINdrikerlqscyrgegtldlawlkvkdipcssalLTIDDNFCGLDmNAPLGVSDMVrgipvftedRD 430
Cdd:cd09295    274 VESAVCAYLFTDIN---------------------------------NVFDDPVEAIN-NRPLYAHQNQ---------RS 310

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  431 RMTSVIAYVYK----NHSLAFVGTKSGKLKKIRVDGPRGNALQYETVQVVDPGPVLRDMAFSKDHEQLYIMSERQLTRVP 506
Cdd:cd09295    311 RLTSIAVDATKqksvGYQVVFLGLKLGSLGKALAFFFLYKGHIIEEWKVFKDSSRITNLDLSRPPLYLYVGSESGVLGVP 390


                   ..
gi 2217369006  507 VE 508
Cdd:cd09295    391 VQ 392
Sema_plexin_B3 cd11277
The Sema domain, a protein interacting module, of Plexin B3; Plexin B3 is the receptor of ...
 47-507 1.74e-58

The Sema domain, a protein interacting module, of Plexin B3; Plexin B3 is the receptor of semaphorin 5A. It is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin B3 has been linked to verbal performance and white matter volume in human brain. Furthermore, Sema5A and plexin B3 have been implicated in the progression of various types of cancer. They play an important role in the invasion and metastasis of gastric carcinoma. The stimulation of plexin B3 by Sema5A binding in human glioma cells results in the inhibition of cell migration and invasion. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200538 [Multi-domain]  Cd Length: 434  Bit Score: 208.90  E-value: 1.74e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006   47 PAEGFNHLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHETGPDEDNPKCYPPRIVQTCNEPlTTTNNVNKMLLIDYKENR 126
Cdd:cd11277      4 PNATFNHLALDPGSGTLYVGAVNRLYQLSPDLQLLGEAVTGPVLDSPDCLPFRDPADCPQA-RLTDNANKLLLVSERAGE 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  127 LIACGSLYQGICKLLRLED----LFKLGEPyhkKEHYLSGVNESG-SVFGVIVSYSNLdDKLFIATAVDGK-PEYFPTIS 200
Cdd:cd11277     83 LVACGQVRQGVCEKRRLGNvaqvLYQAEDP---GDGQFVAANDPGvATVGLVVEAPGR-DLLLVGRGLTGKlSAGIPPLT 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  201 SRKLTKnseadgmfAYVFHDEFVASMikipsdtftIIPDFDIY---YVYGFSSGNFVYFLtlqpemVSPPGSTTKEQvYT 277
Cdd:cd11277    159 IRQLAG--------AQAFSSEGLGKL---------VVGDFSDYnnsYVGAFAHNGYVYFL------FRRRGARAQAE-YR 214

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  278 SKLVRLCKEDTAFNSYVEVPIGCERSgveYRLLQAAYLSkagavlgrtlgvhPDDDLLFTVFSKGQKRKMKSLDESALCI 357
Cdd:cd11277    215 TYVARVCLGDTNLYSYVEVPLVCQGG---YNLAQAAYLA-------------PGQGTLFVVFAAGQGSTPTPTDQTALCA 278

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  358 FILKQINDRIKERLQSCYRGEGtldlawlkvKDIP--------------CSSALLTIDDNF-CGLDMN-APLGVSDMVRG 421
Cdd:cd11277    279 YPLVELDSAMERARRLCYTAGG---------GGPNgkeeatieygvtsrCVNLPKDSPESYpCGDEHTpSPIASRQPLEA 349

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  422 IPVFTeDRDRMTSVIAYVYKNHSLAFVGTKSGKLKKIRVDGPRGNAlqYETVQVVDPG-PVLRDMAFSKDHEQLYIMSER 500
Cdd:cd11277    350 EPLLT-LTPPLTAVAALQEDGHTIAFLGDTQGQLHKVFLNGSAGQV--YSSQPVGPPGsAVNPDLLLDATGSHLYVLTAR 426


                   ....*..
gi 2217369006  501 QLTRVPV 507
Cdd:cd11277    427 QVTKVPV 433
Sema_plexin_B1 cd11275
The Sema domain, a protein interacting module, of Plexin B1; Plexin B1 serves as the ...
 51-507 1.20e-57

The Sema domain, a protein interacting module, of Plexin B1; Plexin B1 serves as the Semaphorin 4D receptor and functions as a regulator of developing neurons and a tumor suppressor protein for melanoma. The Sema4D-plexin B signaling complex regulates dendritic and axonal complexity. The activation of Plexin B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. As a tumor suppressor, plexin B1 abrogates activation of the oncogenic receptor, c-Met, by its ligand, hepatocyte growth factor (HGF), in melanoma. Furthermore, plexin B1 suppresses integrin-dependent migration and activation of pp125FAK and inhibits Rho activity. Plexin B1 is highly expressed in endothelial cells and its activation by Sema4D elicits a potent proangiogenic response. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200536 [Multi-domain]  Cd Length: 461  Bit Score: 207.12  E-value: 1.20e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006   51 FNHLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHETGPDEDNPKCYPPRIVQTCNEPlTTTNNVNKMLLIDYKENRLIAC 130
Cdd:cd11275      8 FLHLSMDPESGTLYLGATNFLFQLTPDLLLENMVQTGPVLDSKDCLPPVSKLECPQA-QHTNNHNKLLLVNPVQKELIVC 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  131 GSLYQGICKLLRLEDLfklgepyhkkEHYLSGVNESGSVFGVIVSYSNLDDKLFIATAVDGKPEYF-------------- 196
Cdd:cd11275     87 GSVHQGICEKRRLGSI----------DHVLFRPERPGDTQYVAANDPNVTTVGLVAYSKDGVPLLFvgrgytsrgvgggi 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  197 PTISSRKLTKNSEADGMFAYVFHDEFVASMikipsdTFTIIPDFDIYYVYGFSSGNFVYFLTLQPEMVSppgsttKEQVY 276
Cdd:cd11275    157 PPITTRNLRAHGDDATDSHSIFSYEETAKL------AVGRLSEYNHHFIKAFTYGSSVYFLFYRRDLKS------QSREY 224

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  277 TSKLVRLCKEDTAFNSYVEVPIGCERSGVEYRLLQAAYLSKAGAVLGRTLGVhPDDDLLFTVFSKGQKRKMKSLDESALC 356
Cdd:cd11275    225 KTYISRICLDDSHYYSYVELPLLCQSKANTYSLLQAAYVTQPGERLAQGQLD-TDGEVLFAAFSAWQASSGKLSEESALC 303

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  357 IFILKQINDRIKERLQSCY----RGEGTLDLAWLKVkDIPCSSALL---TIDDNFCGLDMN-APLGVSDMVRGIPVFTED 428
Cdd:cd11275    304 AYPMDEVDRLTNWTRDVCYtrdgKAEDGTEVAYIEY-DVSSNCVQLpadTLDAYPCGSDHTpSPMASRVPLEATPLLEWT 382

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217369006  429 RDRMTSVIAYVYKNHSLAFVGTKSGKLKKIRVdGPRGNALQYETVQVVDPGPVLRDMAFSKDHEQLYIMSERQLTRVPV 507
Cdd:cd11275    383 EIRLTAVAVNVEDGHTIAFLGDSRGRLHKVYL-GAGGDAHTYSSQSIQQNSAVSGDLLFDQLQEHLYVMTQSTVLKVPI 460
Sema_MET_like cd11248
The Sema domain, a protein interacting module, of MET and RON receptor tyrosine kinases; This ...
 54-507 4.52e-48

The Sema domain, a protein interacting module, of MET and RON receptor tyrosine kinases; This family includes MET and RON receptor tyrosine kinases. MET is encoded by the c-met protooncogene. MET is the receptor for hepatocyte growth factor/scatter factor (HGF/SF). HGF/SF and MET regulates multiple cellular events and are essential for the development of several tissues and organs, including the placenta, liver, and several groups of skeletal muscles. RON receptor tyrosine kinase is a Macrophage-stimulating protein (MSP) receptor. Upon binding of MSP, RON is activated via autophosphorylation within its kinase catalytic domain, resulting in a variety of effects including proliferation, tubular morphogenesis, angiogenesis, cellular motility and invasiveness. By interacting with downstream signaling molecules, it regulates macrophage migration, phagocytosis, and nitric oxide production. MET and RON receptors have been implicated in cancer development and migration. They are composed of alpha-beta heterodimers. The extracellular alpha chain is disulfide linked to the beta chain, which contains an extracellular ligand-binding region with a Sema domain, a PSI domain and four IPT repeats, a transmembrane segment, and an intracellular catalytic tyrosine kinase domain. The Sema domain is necessary for receptor dimerization and activation.


Pssm-ID: 200509 [Multi-domain]  Cd Length: 467  Bit Score: 179.15  E-value: 4.52e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006   54 LVVDERTGHIYLGAVNRIYKLSSDLKVLVTHETGPdEDNPKCypprivQTCN------EPLTTTNNVNKMLLID-YKENR 126
Cdd:cd11248     13 IVLNEGSTEVYVAAQNVIYALNPDLQKVWEYKTGP-VGSPDC------QTCQdcssgaDPGVPKDTDNMVLVLEtYYDDY 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  127 LIACGSLYQGICKLLRLEDLFKLGEP----YHKKE---HYLSGVNESGSVFGVIVSYSNLDDKLFIATAVDgkPEYFP-- 197
Cdd:cd11248     86 LYSCGSTQNGVCYRHVLEDGADIQSEvhclFSKKNnspSYCPDCVASPLGTKVTNVESGRTIYFFVANSVN--SSLAGsf 163

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  198 ---TISSRKLtKNSEaDGmfayvFHDEFvASMIKIPS--DTFTIipdfdiYYVYGFSSGNFVYFLTLQPEMVSPPGSTtk 272
Cdd:cd11248    164 pphSISVRRL-KEDG-FG-----FLSDQ-SYLDVLPSlrDSYPI------KYVYSFHSGPFVYFLTVQRESLTKPSSA-- 227

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  273 eqvYTSKLVRLCKEDTAFNSYVEVPIGC------ERSGVE----YRLLQAAYLSKAGAVLGRTLGVHPDDDLLFTVFSKG 342
Cdd:cd11248    228 ---FHTRLVRLCSSDSEIWRYREMPLECiftpkrRRRSTEedvvYNVLQAAHVSKVGADLADELGASEGDDILFGVFARS 304

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  343 QKRKMKSLDESALCIFILKQINDRIKERLQSC--------YRGEGtldlawlkvKDIPCSSalLTIDDNFCGLDMNA-PL 413
Cdd:cd11248    305 KPDSGEPMPNSALCAFPIKYVNDAIEKGVEKCctsglehfSGSLC---------HFQPCPT--CPGESSSCEATCKEyRT 373

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  414 GVSDMVRGIPVFT-EDRD-RMTSVIAYVYKNHSLAFVGTKSGKLKKIRVD--GPRGNAlQYEtvqvVDPGPVLRDMAFSK 489
Cdd:cd11248    374 EVTKPYQRVDLFNgQMSNvLLTSILVTTIGNHTVAHLGTSDGRVLQVVLSrsGPIPHV-NFS----LDSQPVSREVAVLS 448

                          490
                   ....*....|....*...
gi 2217369006  490 DHEQLYIMSERQLTRVPV 507
Cdd:cd11248    449 SNGSLLFVTGDKITKVPL 466
IPT_plexin_repeat3 cd01181
Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1040-1140 8.47e-47

Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238586  Cd Length: 99  Bit Score: 162.59  E-value: 8.47e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006 1040 PTIVRIEPEWSIVSGNTPIAVWGTHLDLIQNPQIRAKHGGKEHINiCEVLNATEMTCQAPALALGPDHQsDLTERPEEFG 1119
Cdd:cd01181      1 PTITRIEPEWSFLSGGTPITVTGTNLNTVQEPRIRVKYGGVEKTS-CKVRNSTLMTCPAPSLALLNRSP-EPGERPVEFG 78

                           90       100
                   ....*....|....*....|.
gi 2217369006 1120 FILDNVQSLLILNKTNFTYYP 1140
Cdd:cd01181     79 LDGDNVQSLLILNRTSFSYYP 99
TIG_2 pfam18020
TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG ...
 708-802 1.12e-39

TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG domains have an Ig-like fold.


Pssm-ID: 465619  Cd Length: 94  Bit Score: 142.03  E-value: 1.12e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  708 DKILVPVEVIKPITLKAKNLPQPQSGQRGYECILNIQGSEQRVPALRFNSSSVQCQNTSYSYEGMeINNLPVELTVVWNG 787
Cdd:pfam18020    1 GSILVPVGVEREITLKARNLPLFQSGQLGYECVFEIEGATHVVPASRESSDSITCQEHQFSYSGS-SGELPATFYVTWNG 79

                           90
                   ....*....|....*
gi 2217369006  788 HFNIDNPAQNKVHLY 802
Cdd:pfam18020   80 GHRLDNPANLQVVLY 94
Sema_MET cd11278
The Sema domain, a protein interacting module, of MET (also called hepatocyte growth factor ...
 61-365 4.09e-39

The Sema domain, a protein interacting module, of MET (also called hepatocyte growth factor receptor, HGFR); MET is encoded by the c-met protooncogene. MET is a receptor tyrosine kinase that binds its ligand, hepatocyte growth factor/scatter factor (HGF/SF). HGF/SF and MET are essential for the development of several tissues and organs, including the placenta, liver, and several groups of skeletal muscles. It also plays a major role in the abnormal migration of cancer cells as a result of overexpression or MET mutations. MET is composed of an alpha-beta heterodimer. The extracellular alpha chain is disulfide linked to the beta chain, which contains an extracellular ligand-binding region with a Sema domain, a PSI domain and four IPT repeats, a transmembrane segment, and an intracellular catalytic tyrosine kinase domain. The cytoplasmic C-terminal region acts as a docking site for multiple protein substrates, including Grb2, Gab1, STAT3, Shc, SHIP-1 and Src. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. The Sema domain of Met is necessary for receptor dimerization and activation.


Pssm-ID: 200539 [Multi-domain]  Cd Length: 492  Bit Score: 153.48  E-value: 4.09e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006   61 GHIYLGAVNRIYKLSSDLKVLVTHETGPDEDNPKCYPpriVQTCNEPLTTTN-----NVNKMLLI-DYKENRLIACGSLY 134
Cdd:cd11278     36 HHIYVGAVNKIYVLNEDLQKVSEYKTGPVLEHPDCFP---CQDCSDKANLSNgvwkdNVNMALFVeTYYDDQLISCGSVN 112

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  135 QGICKllrlEDLFKLGEPYHKKEH----YLSGVNESG--------SVFG--VIVSYSNLDDKLFIATAVDG---KPEYFP 197
Cdd:cd11278    113 RGTCQ----RHVFPHDHPADIQSEvhciYSPQIEEEPdqcpdcvvSTLGskVLVTVKDRFVNFFVGNTINSsyfPDHPLH 188

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  198 TISSRKLTKNSeaDGmFAYVFHDEFVasmikipsdtfTIIPDF-DIY---YVYGFSSGNFVYFLTLQPEmvsppgsTTKE 273
Cdd:cd11278    189 SISVRRLKETQ--DG-FEFLTDQSYI-----------DVLPEFrDSYpikYVHAFESNNFVYFLTVQRE-------SLDS 247

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  274 QVYTSKLVRLCKEDTAFNSYVEVPIGC-------ERS--GVEYRLLQAAYLSKAGAVLGRTLGVHPDDDLLFTVFSKGQK 344
Cdd:cd11278    248 QTFHTRIIRFCSIDSELRSYMEMPLECiftekrrKRStkKEVFNILQAAYVSKPGAQLAREMGASLNDDILFGVFAQSKP 327

                          330       340
                   ....*....|....*....|.
gi 2217369006  345 RKMKSLDESALCIFILKQIND 365
Cdd:cd11278    328 DSAEPMNRSAVCAVSIKTINE 348
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 955-1038 2.32e-34

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 126.57  E-value: 2.32e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  955 TLSDLKPSRGPMSGGTQVTITGTNLNAGSNVVVMFGKQPCLFHRRSPSYIVCNTTSSDEVLEMKVSVQVDRAKIHQDLVF 1034
Cdd:cd01179      2 SITSLSPSYGPQSGGTRLTITGKHLNAGSSVRVTVGGQPCKILSVSSSQIVCLTPPSASPGEAPVKVLIDGARRLAPLVF 81


                   ....
gi 2217369006 1035 QYVE 1038
Cdd:cd01179     82 TYTE 85
Sema pfam01403
Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and ...
 310-488 4.16e-31

Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and Swiss:P51805


Pssm-ID: 460197 [Multi-domain]  Cd Length: 180  Bit Score: 120.84  E-value: 4.16e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  310 LQAAYLSKAGAVLGRtlgvhpdDDLLFTVFSKGQKrkmKSLDESALCIFILKQINDRIKERlqscYRGEGTLDLAWLKV- 388
Cdd:pfam01403    1 LQDVFVLKPGAGDAL-------DTVLYGVFTTQWS---NSIGGSAVCAFSLSDINAVFEGP----FKEQEKSDSKWLPYt 66

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  389 ------KDIPC--SSALLTIDDNFCGLDMNAPLGVS--DMVRGIPVFTEDRDRMTSVIAY----VYKNHSLAFVGTKSGK 454
Cdd:pfam01403   67 gkvpypRPGTCinDPLRLDLPDSVLNFVKDHPLMDEavQPVGGRPLLVRTGVRLTSIAVDrvqaLDGNYTVLFLGTDDGR 146

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 2217369006  455 LKKIrVDGPRGNALQYETVQVVDPG-PVLRDMAFS 488
Cdd:pfam01403  147 LHKV-VLVGSEESHIIEEIQVFPEPqPVLNLLLSS 180
Sema_RON cd11279
The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase; RON receptor ...
 54-507 9.03e-29

The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase; RON receptor tyrosine kinase is a Macrophage-stimulating protein (MSP) receptor. Upon binding of MSP, RON is activated via autophosphorylation within its kinase catalytic domain, resulting in a wide range of effects, including proliferation, tubular morphogenesis, angiogenesis, cellular motility and invasiveness. By interacting with downstream signaling molecules, it regulates macrophage migration, phagocytosis, and nitric oxide production. RON has been implicated in cancers of the breast, colon, pancreas and ovaries because both splice variants and receptor overexpression have been identified in these tumors. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as ligand recognition and binding model. RON is composed of an alpha-beta heterodimer. The extracellular alpha chain is disulfide linked to the beta chain, which contains an extracellular ligand-binding region with a Sema domain, a PSI domain and four IPT repeats, a transmembrane segment, and an intracellular catalytic tyrosine kinase domain. The Sema domain of RON may be necessary for receptor dimerization and activation.


Pssm-ID: 200540 [Multi-domain]  Cd Length: 493  Bit Score: 122.20  E-value: 9.03e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006   54 LVVDERTGHIYLGAVNRIYKLSSDLKVLVTHETGPdEDNPKCYPPRIVQTCNEPLTTTNNVNKMLLIDYKENRLIACGSL 133
Cdd:cd11279     32 IVSYEDASAVFVATRNHLHVLNPELKLLQNLVTGP-TGSPGCQICALCPPGPPGPSPEDTDNKVLVLDPEEPWLYSCGSS 110

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  134 YQGICKLLRLE---DLFKLGEP---YHKKEHYLSGVNES-GSVFG--VIVSYSNLDDKLFIATAVDGK--PEYFPT-ISS 201
Cdd:cd11279    111 LHGRCFLHELEsrgSAVHIASTaclFSANANKPSDCPDCvASPLGtrVTVVEQSHTSYFYVASTLNSSvaASYSPRsVSI 190

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  202 RKLtkNSEADGmFAYVFHdefvasmikipsdTFTIIPDF----DIYYVYGFSSGNFVYFLTLQPEmvSPPGSTtkeqvYT 277
Cdd:cd11279    191 RRL--KSDQDG-FAPGFH-------------SLTVLPKYldsyPIHYVHSFTSGDFVYFLTVQPE--SPDSSA-----YH 247

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  278 SKLVRLCKEDTAFNSYVEVPIGC------------ERSGVEYRLLQAAYLSKAGAVLGRTLGVHPDDDLLFTVFSKGQKR 345
Cdd:cd11279    248 TRLVRLSAKEPELRDYRELVLDCrfepkrrrrrrpAEREVPYNVLQAAHAAPVGSKLAVELGISEGQEVLFGVFAESQPG 327

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  346 KMKSLDESALCIFILKQINDRIKERLQSC---------YRGegtldLAWLKVK----DIPCSSALLTidDNFCgldMNAP 412
Cdd:cd11279    328 SPVPQKNSAVCAFPISLLNEAIDEGMEKCcsssnsdrlFRG-----LDFFQPQsycpHPPNLSAAVS--NTSC---WNFP 397

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  413 LGVSDMVRGIPVFTEDRD--RMTSVIAYVYKNHSLAFVGTKSGKLKKIRVDGPRGNALQYETVQVVDPGPVLRDMAFSKD 490
Cdd:cd11279    398 TLVSTSSFRVDLFNGHLSgvLLTSIYVTVLDNVTVAHLGTSDGRILQVVLQRSLNYLLYVSNFSLGDGQPVQRDVSRLGD 477

                          490
                   ....*....|....*..
gi 2217369006  491 HeqLYIMSERQLTRVPV 507
Cdd:cd11279    478 S--LLFASGNQVFKVNI 492
Sema_plexin_D1 cd11247
The Sema domain, a protein interacting module, of Plexin D1; Plexins are known as semaphorin ...
 52-507 1.14e-27

The Sema domain, a protein interacting module, of Plexin D1; Plexins are known as semaphorin receptors and Plexin D1 has been identified as the receptor of Sema3E. It binds to Sema3E directly with high affinity. Sema3E is implicated in axonal path finding and inhibition of developmental and post-ischemic angiogenesis. Plexin D1 is broadly expressed on tumor vessels and tumor cells in a number of different types of human tumors. Plexin D1-Sema3E interaction inhibits tumor growth but promotes invasiveness and metastasis. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200508 [Multi-domain]  Cd Length: 483  Bit Score: 118.80  E-value: 1.14e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006   52 NHLVVDERTGHIYLGAVNRIYKLS-SDLKVLVTHETGPDEDNPKCYPPRIVQ-TCNEPLTTTNNVNKMLLIDYKENRLIA 129
Cdd:cd11247     12 NNFALDGGRGRLYLAAVNRLYQLSgLVLALEAEAAVGPVLDSPLCHAPQLPQaTCEHPRTLTDNYNKILQPDPEQGVLVV 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  130 CGSLYQGICKLLRLEDLFKLGEPYHKK-----EHYLS--GVNESGSVFGVIVSYSN--LDDKLFIATAVDGK-PEYF--- 196
Cdd:cd11247     92 CGSIYQGLCQLRRLYNISAVAVRFPVDgdtvfPSMLNvaANHPNASTVGLVLWPRGggGGLRLLVGATYTGYgSGFFprn 171

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  197 -----------PTISSRKLTKNSEADGMFAYVFHdefvasmikiPSDT--FTIIPDFDIYYVYGFSSGNFVYFltLQP-- 261
Cdd:cd11247    172 rsledhrfentPEIAIRALNTRGDLAKLFTFDIN----------PSDDniFKIKQGAKARHKLSFVRAFLQHF--LQPya 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  262 --EMVSPPGSTTKEQVYTSKLVRLCKEDTAFN----------SYVEVPIGCERSGveyrllqaaylskagavlGRTLGVH 329
Cdd:cd11247    240 ylAMNGEANAAGKESQPPSLLARICLPGRAPPppgeakklteSYIQLGLRCEGAY------------------TRLVSVF 301

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  330 P---DDDLLFTVFSKGQKrkmkslDESALCIFILKQINDRIKERLQSCYRGEGTLDLAWL----KVKDIPCSSAL---LT 399
Cdd:cd11247    302 ParvEEEQLFAVFERAGG------APAALCAFRFAEVEEPIRAARTACFVSPAAGVVTVLdsvvQGTGPACERKLniqLQ 375

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  400 IDDNFCG-LDMNAPLGVSDMVRGIPVFTEdrDRMTSVIAYVYKNHSLAFVGTKSGKLKKIRVDGPRgNALQYETVQVVDP 478
Cdd:cd11247    376 PEQLDCGaAHLQHPLAILQPLKATPVFRA--PGLTSVAVASVNNYTVVFLGTVSGRLLKINLDESM-QVVSRRSVTVAYG 452

                          490       500       510
                   ....*....|....*....|....*....|
gi 2217369006  479 GPVLRDMAFS-KDHEQLYIMSERQLTRVPV 507
Cdd:cd11247    453 EPVHHVMQFDpSDSTYLYLMTSHQMTRVKV 482
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 858-953 1.44e-26

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 104.71  E-value: 1.44e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  858 PRITEIIPVTGPREGGTKVTIRGENLGLEFRDIASHVKVAGVECSPLVDGYIPAEQIVCEMGEAKPSQHAGFVEICVAVC 937
Cdd:cd01180      1 PVITEFFPLSGPLEGGTRLTICGSNLGLRKNDVRHGVRVGGVPCNPEPPEYSSSEKIVCTTGPAGNPVFNGPVEVTVGHG 80

                           90
                   ....*....|....*.
gi 2217369006  938 rpEFMARSSQLYYFMT 953
Cdd:cd01180     81 --SFRTESSEGFSFVD 94
TIG_plexin pfam17960
TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and ...
 564-654 7.13e-24

TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and Transcription factors) found in plexins.


Pssm-ID: 465588  Cd Length: 89  Bit Score: 96.95  E-value: 7.13e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  564 HPNNISVSQY-NVLLVLEtyNVPELSAGVNCTFEDLSEMDGLVVGNQIQCYSPAAKEVPRIiTENGDHHVVQLQLKSKET 642
Cdd:pfam17960    1 TPDNISRTTAtQLTLTVP--NLPALSEGYSCVFGDLTESPATVHDNGVKCATPPPSQLPPI-PTGQDHVTVKLSLRSSET 77

                           90
                   ....*....|..
gi 2217369006  643 GMTFASTSFVFY 654
Cdd:pfam17960   78 GVDFASTNFTFY 89
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 955-1038 2.94e-20

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 86.74  E-value: 2.94e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  955 TLSDLKPSRGPMSGGTQVTITGTNLNAGS-NVVVMFGKQPCLFHRRSPSYIVCNTTSSDEVLEMKVSVQVDRA----KIH 1029
Cdd:cd00603      2 VITSISPSSGPLSGGTRLTITGSNLGSGSpRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPGEGPVEVTVDGAnvsaRVL 81


                   ....*....
gi 2217369006 1030 QDLVFQYVE 1038
Cdd:cd00603     82 SNTTFTYVE 90
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 954-1038 9.03e-18

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 79.43  E-value: 9.03e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  954 LTLSDLKPSRGPMSGGTQVTITGTNLNAGSNVVVMF-GKQPCLFHRRSPSYIVCNTTSSDEVLEMKVSVQVDRA---KIH 1029
Cdd:cd00102      1 PVITSISPSSGPVSGGTEVTITGSNFGSGSNLRVTFgGGVPCSVLSVSSTAIVCTTPPYANPGPGPVEVTVDRGnggITS 80


                   ....*....
gi 2217369006 1030 QDLVFQYVE 1038
Cdd:cd00102     81 SPLTFTYVP 89
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 858-952 2.67e-15

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 72.49  E-value: 2.67e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  858 PRITEIIPVTGPREGGTKVTIRGENLGLEFRDIAshVKVAGVECSPLVDGyipAEQIVCEMGEAKPSQHAGfVEICVAVC 937
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRVR--VTVGGVPCKVLNVS---STEIVCRTPAAATPGEGP-VEVTVDGA 74

                           90
                   ....*....|....*
gi 2217369006  938 RPEFMARSSQLYYFM 952
Cdd:cd00603     75 NVSARVLSNTTFTYV 89
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
510-548 1.01e-13

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 66.80  E-value: 1.01e-13
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 2217369006   510 CGQYQSCGECLGSGDPHCGWCVLHNTCTRKERCERSKEP 548
Cdd:smart00423    2 CSKYTSCSECLLARDPYCAWCSSQGRCTSGERCDSRRQN 40
IPT smart00429
ig-like, plexins, transcription factors;
1039-1139 2.05e-13

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 67.06  E-value: 2.05e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  1039 DPTIVRIEPEWSIVSGNTPIAVWGTHLDLIQNPQIRAKHGGKEhiniCEVLN--ATEMTCQAPalalgPDHQSDLTERPE 1116
Cdd:smart00429    1 DPVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVGEAP----CTFSPssSTAIVCKTP-----PYHNIPGSVPVR 71

                            90       100
                    ....*....|....*....|...
gi 2217369006  1117 EFGFILDNVQSLlilnKTNFTYY 1139
Cdd:smart00429   72 TVGLRNGGVPSS----PQPFTYV 90
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1040-1140 3.36e-13

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 66.71  E-value: 3.36e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006 1040 PTIVRIEPEWSIVSGNTPIAVWGTHLDLIQnPQIRAKHGGKEhiniCEVL--NATEMTCQAPALALGPdhqsdltERPEE 1117
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLGSGS-PRVRVTVGGVP----CKVLnvSSTEIVCRTPAAATPG-------EGPVE 68

                           90       100
                   ....*....|....*....|...
gi 2217369006 1118 FGFILDNVqSLLILNKTNFTYYP 1140
Cdd:cd00603     69 VTVDGANV-SARVLSNTTFTYVE 90
IPT smart00429
ig-like, plexins, transcription factors;
857-950 4.06e-13

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 66.29  E-value: 4.06e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006   857 NPRITEIIPVTGPREGGTKVTIRGENLGlEFRDIASHVKVAGVECSPLVDGyipAEQIVCEMGEAKPSQHAGFVEiCVAV 936
Cdd:smart00429    1 DPVITRISPTSGPVSGGTEITLCGKNLK-SISVVFVEVGVGEAPCTFSPSS---STAIVCKTPPYHNIPGSVPVR-TVGL 75

                            90
                    ....*....|....
gi 2217369006   937 CRPEFMARSSQLYY 950
Cdd:smart00429   76 RNGGVPSSPQPFTY 89
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 509-551 5.61e-13

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 64.65  E-value: 5.61e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 2217369006  509 SCGQYQSCGECLGSGDPHCGWCVLHNTCTRKERCERSKEPRRF 551
Cdd:pfam01437    1 RCSQYTSCSSCLAARDPYCGWCSSEGRCVRRSACGAPEGNCEE 43
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 954-1036 1.68e-12

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 64.39  E-value: 1.68e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  954 LTLSDLKPSRGPMSGGTQVTITGTNLNAGS-NVVVMFGKQPCLFHRRSPSYIVCNTTSSDEVLeMKVSVQV-DRAKIHQD 1031
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSsDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGL-VNVSVTVgGGGISSSP 79


                   ....*
gi 2217369006 1032 LVFQY 1036
Cdd:pfam01833   80 LTFTY 84
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 858-950 8.26e-12

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 62.48  E-value: 8.26e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  858 PRITEIIPVTGPREGGTKVTIRGENLGLEFRdiaSHVKV-AGVECSPLVDGyipAEQIVCEMGEAKPSQHagfVEICVAV 936
Cdd:cd00102      1 PVITSISPSSGPVSGGTEVTITGSNFGSGSN---LRVTFgGGVPCSVLSVS---STAIVCTTPPYANPGP---GPVEVTV 71

                           90
                   ....*....|....
gi 2217369006  937 CRPEFMARSSQLYY 950
Cdd:cd00102     72 DRGNGGITSSPLTF 85
IPT smart00429
ig-like, plexins, transcription factors;
954-1037 1.55e-11

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 61.67  E-value: 1.55e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006   954 LTLSDLKPSRGPMSGGTQVTITGTNLNAGSNVVVMF--GKQPCLFHRRSPSYIVCNTTS-SDEVLEMKVS-VQVDRAKIH 1029
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVgvGEAPCTFSPSSSTAIVCKTPPyHNIPGSVPVRtVGLRNGGVP 81


                    ....*....
gi 2217369006  1030 -QDLVFQYV 1037
Cdd:smart00429   82 sSPQPFTYV 90
RasGAP_plexin_A cd12790
Ras-GTPase Activating Domain of type A plexins; Plexins form a conserved family of ...
 1311-1339 1.66e-11

Ras-GTPase Activating Domain of type A plexins; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. They are divided into four types (A-D) according to sequence similarity. In vertebrates, there are four type A plexins (A1-A4) that serve as the co-receptors for neuropilins to mediate the signaling of class 3 semaphorins except Sema3E, which signals through Plexin-D1. Plexins serve as direct receptors for several other members of the semaphorin family: class 1 and class 6 semaphorins signal through type A plexins, which mediate diverse biological functions including axon guidance, cardiovascular development, and immune function. Guanylyl cyclase Gyc76C and Off-track kinase (OTK), a putative receptor tyrosine kinase, modulate Sema1a and Plexin-A mediated axon repulsion. In their complex with Sema6s, type A plexins serve as signal-transducing subunits. An increasing number of molecules that interact with the intracellular region of Plexin-A have been identified; among them are IgCAMs (in axon guidance events) and Trem2-DAP12 (in immune responses). Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213350 [Multi-domain]  Cd Length: 385  Bit Score: 67.83  E-value: 1.66e-11
                           10        20
                   ....*....|....*....|....*....
gi 2217369006 1311 GIPFLDYRTYTMRVLFPGIEDHPVLRDLE 1339
Cdd:cd12790      1 GIPFLDYRTYAMRVLFPGIEDHPVLRELE 29
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 858-937 1.06e-10

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 59.38  E-value: 1.06e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  858 PRITEIIPVTGPREGGTKVTIRGENLGLEFRDIasHVKVAGVECSPLvdgYIPAEQIVCEMgeakPSQHAGFVEICVAVC 937
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDL--KVTIGGTPCTVI---SVSSTTIVCTT----PPGTSGLVNVSVTVG 71
Sema_semaphorin cd11235
The Sema domain, a protein interacting module, of semaphorins; Semaphorins are regulator ...
 53-507 6.14e-10

The Sema domain, a protein interacting module, of semaphorins; Semaphorins are regulator molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. They can be divided into 7 classes. Vertebrates have members in classes 3-7, whereas classes 1 and 2 are known only in invertebrates. Class 2 and 3 semaphorins are secreted proteins; classes 1 and 4 through 6 are transmembrane proteins; and class 7 is membrane associated via glycosylphosphatidylinositol (GPI) linkage. The semaphorins exert their function through their receptors, the neuropilin and plexin families. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200496 [Multi-domain]  Cd Length: 437  Bit Score: 63.20  E-value: 6.14e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006   53 HLVVDERTGHIYLGAVNRIYKLS----SDLKVLVTHETGPDEDnpKCYPPRIVQT-CnepltttNNVNKMLLiDYKENRL 127
Cdd:cd11235      5 TKLLHEDRSTLYVGARDRVYLVDldslYTEQKVAWPSSPDDVD--TCYLKGKSKDdC-------RNFIKVLE-KNSDDSL 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  128 IACGS-LYQGICKLLRLED---LFKLGE-----PYHKKEHYLSgvnesgsvfgvIVSysnlDDKLFIATAVD---GKPEY 195
Cdd:cd11235     75 LVCGTnAFNPSCRNYNVETfelVGKEESgrgkcPYDPDHNSTA-----------LFA----DGELYSGTSADflgTDPVI 139

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  196 FPTISSRKLTKNSEADgmfayvfhdefvasmikipsDTFTIIPDFdiyyVYGFSSGNFVYFLTLQpemVSPPGSTTKEQV 275
Cdd:cd11235    140 YRTLGHNPPLRTEYHD--------------------SKWLNEPQF----VGAFDIGDYVYFFFRE---IAVEYINCGKAV 192

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  276 YtSKLVRLCKEDT--------AFNSYVEVPIGCERSG---VEYRLLQAAYLSKAGAvlgrtlgvhPDDDLLFTVFSKgqk 344
Cdd:cd11235    193 Y-SRVARVCKNDQggsrslekKWTTFLKARLNCSVPGefpFYFNELQDVFDLPSPS---------NKEKIFYAVFTT--- 259

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  345 rKMKSLDESALCIFILKQINdrikERLQSCYRGEGTLDLAWLKVKD-IPCSSALLT-IDD--NFCGLDMN----APLgVS 416
Cdd:cd11235    260 -PYNSIPGSAVCAYSLSDIE----AVFNGPFKEQHSSNSAWLPVPDeRVPEPRPGTcVDDssPLPDDTLNfiksHPL-MD 333

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  417 DMVRGI---PVF--TEDRDRMTSVI-----AYVYKNHSLAFVGTKSGKLKKIRVdgPRGNALQ----YETVQVVDPGPVL 482
Cdd:cd11235    334 EAVTPIlnrPLFikTDVNYRFTKIAvdrvqAKLGQTYDVLFVGTDRGIILKVVS--LPEQGLQasniLEEMPVGPPPEPI 411

                          490       500
                   ....*....|....*....|....*
gi 2217369006  483 RDMAFSKDHEQLYIMSERQLTRVPV 507
Cdd:cd11235    412 QTMQLSRKRRSLYVGSETGVLQVPL 436
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1040-1140 6.47e-10

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 57.09  E-value: 6.47e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006 1040 PTIVRIEPEWSIVSGNTPIAVWGTHLDliQNPQIRAKHGGKEHINIcEVLNATEMTCQAPALALGPDHQSDLTerpeefg 1119
Cdd:cd00102      1 PVITSISPSSGPVSGGTEVTITGSNFG--SGSNLRVTFGGGVPCSV-LSVSSTAIVCTTPPYANPGPGPVEVT------- 70

                           90       100
                   ....*....|....*....|.
gi 2217369006 1120 fiLDNVQSLLILNKTNFTYYP 1140
Cdd:cd00102     71 --VDRGNGGITSSPLTFTYVP 89
Plexin_cytopl pfam08337
Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various ...
 1311-1343 2.57e-09

Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various plexins. Plexins are receptors for semaphorins, and plexin signalling is important in path finding and patterning of both neurons and developing blood vessels. The cytoplasmic region, which has been called a SEX domain in some members of this family, is involved in downstream signalling pathways, by interaction with proteins such as Rac1, RhoD, Rnd1 and other plexins. This domain acts as a RasGAP domain.


Pssm-ID: 462434 [Multi-domain]  Cd Length: 500  Bit Score: 61.44  E-value: 2.57e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 2217369006 1311 GIPFLDYRTYTMRVLFPGIEDHPVLRDLEASVL 1343
Cdd:pfam08337    1 GIPFLDYRTYAMRVLFPGVEDHPLLVLLDVPVT 33
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 804-856 3.09e-08

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 51.17  E-value: 3.09e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2217369006  804 CGAMReSCGLCLKADpDFACGWCQGPGQCTLRQHCPAQESQWLELSGAKSKCT 856
Cdd:pfam01437    2 CSQYT-SCSSCLAAR-DPYCGWCSSEGRCVRRSACGAPEGNCEEWEQASSKCP 52
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 655-702 1.05e-07

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 49.63  E-value: 1.05e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2217369006  655 NCSVHNSCLSCVESP-YRCHWCKYRHVCTHdPKTCSFQEGR----VKLPEDCP 702
Cdd:pfam01437    1 RCSQYTSCSSCLAARdPYCGWCSSEGRCVR-RSACGAPEGNceewEQASSKCP 52
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 958-1038 3.46e-07

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 49.62  E-value: 3.46e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  958 DLKPSRGPMSGGTQVTITGTNLN---AGSNVVVMFGKQPC--LFHRRSPS-YIVCNT-TSSDEVLEMKVSVQVDR--AKI 1028
Cdd:cd01180      5 EFFPLSGPLEGGTRLTICGSNLGlrkNDVRHGVRVGGVPCnpEPPEYSSSeKIVCTTgPAGNPVFNGPVEVTVGHgsFRT 84

                           90
                   ....*....|
gi 2217369006 1029 HQDLVFQYVE 1038
Cdd:cd01180     85 ESSEGFSFVD 94
Sema_2A cd11238
The Sema domain, a protein interacting module, of semaphorin 2A (Sema2A); Sema2A, a secreted ...
 51-505 4.58e-07

The Sema domain, a protein interacting module, of semaphorin 2A (Sema2A); Sema2A, a secreted semaphorin, signals through its receptor plexin B (PlexB) to regulate central and peripheral axon pathfinding. In the Drosophila embryo, Sema2A secreted by oenocytes interacts with PlexB to guide sensory axons. Sema2A is a member of the semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200499 [Multi-domain]  Cd Length: 452  Bit Score: 53.97  E-value: 4.58e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006   51 FNHLVVDERTGHIYLGAVNRIYKLSSDLkvlVTHETGPDEDNPKCYPPRIVQTC-----NEPLTTTNNVNKMLLIDyKEN 125
Cdd:cd11238      3 YRTLLLDEKRNALYVGAMDRVFRLNLYN---INDTGNNCARDELTLSPSDVSECvskgkDEEYECRNHVRVIQPMG-DGQ 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  126 RLIACGSlyQGICKLLRLEDLFKLGEPyhkkeHYLSGVnesGSVFGVIVSysnldDKLFIATAV---DGKPEYFPTISSR 202
Cdd:cd11238     79 TLYVCST--NAMNPKDRVLDANLLHLP-----EYVPGP---GNGIGKCPY-----DPDDNSTAVwveWGNPGDLPALYSG 143

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  203 KLTKNSEADgmfAYVFH--------DEFVASMIKIPSDTFTII-PDFdiyyVYGFSSGNFVYFL--TLQPEMVSPpgstt 271
Cdd:cd11238    144 TRTEFTKAN---TVIYRpplynntkGRHESFMRTLKYDSKWLDePNF----VGSFDIGDYVYFFfrETAVEYINC----- 211

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  272 kEQVYTSKLVRLCKEDTA--------FNSYVEVPIGCERSGvEYRL----LQAAYlskagAVLGRtlgvhpDDDLLFTVF 339
Cdd:cd11238    212 -GKVVYSRVARVCKKDTGgknvlrqnWTTFLKARLNCSISG-EFPFyfneIQSVY-----KVPGR------DDTLFYATF 278

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  340 SKGQkrkmKSLDESALCIFILKQINDRIkerLQSCYRGEGTLDLAWLKV--KDIP------CSSALLTIDDNFCGLDMNA 411
Cdd:cd11238    279 TTSE----NGFTGSAVCVFTLSDINAAF---DTGKFKEQASSSSAWLPVlsSEVPeprpgtCVNDSATLSDTVLHFARTH 351

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006  412 PLGVSDMVRGIPVFTEDRDRMTSVIAYVYKNHSLAFV----GTKSGKLKKIrVDGPRGNALQYETVQV--VDPGPVLRDM 485
Cdd:cd11238    352 PLMDDAVSHGPPLLYLRDVVFTHLVVDKLRIDDQEYVvfyaGSNDGKVYKI-VHWKDAGESKSNLLDVfeLTPGEPIRAM 430

                          490       500
                   ....*....|....*....|
gi 2217369006  486 AFSKdHEQLYIMSERQLTRV 505
Cdd:cd11238    431 ELLP-GEFLYVASDHRVSQI 449
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
655-702 1.07e-06

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 46.77  E-value: 1.07e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 2217369006   655 NCSVHNSCLSCVESPY-RCHWCKYRHVCTHDPkTCSFQEGRVkLPEDCP 702
Cdd:smart00423    1 RCSKYTSCSECLLARDpYCAWCSSQGRCTSGE-RCDSRRQNW-LSGGCP 47
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1142-1222 1.32e-06

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 47.83  E-value: 1.32e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006 1142 PVFEAFGPS-GILElkPGTPIILKGKNLippvagGNVKLNYTVLVGEKPCTVT-VSDVQLLCESP--NLIGRHKVMARVG 1217
Cdd:cd00603      1 PVITSISPSsGPLS--GGTRLTITGSNL------GSGSPRVRVTVGGVPCKVLnVSSTEIVCRTPaaATPGEGPVEVTVD 72


                   ....*
gi 2217369006 1218 GMEYS 1222
Cdd:cd00603     73 GANVS 77
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
806-849 1.70e-06

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 46.00  E-value: 1.70e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 2217369006   806 AMRESCGLCLKAdPDFACGWCQGPGQCTLRQHCPAQESQWLELS 849
Cdd:smart00423    3 SKYTSCSECLLA-RDPYCAWCSSQGRCTSGERCDSRRQNWLSGG 45
RasGAP_plexin cd12205
Ras-GTPase Activating Domain of plexins; Plexins form a conserved family of transmembrane ...
 1311-1345 3.78e-06

Ras-GTPase Activating Domain of plexins; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Ligand binding activates signal transduction pathways controlling axon guidance in the nervous system and other developmental processes, including cell migration and morphogenesis, immune function, and tumor progression. Plexins are divided into four types (A-D) according to sequence similarity. In vertebrates, type A Plexins serve as the co-receptors for neuropilins to mediate the signaling of class 3 semaphorins except Sema3E, which signals through Plexin D1. Plexins serve as direct receptors for several other members of the semaphorin family: class 6 semaphorins signal through type A plexins and class 4 semaphorins through type B. Plexin C1 serves as the receptor of Sema7A and plays regulation roles in both immune and nervous systems. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Other proteins having a RasGAP domain include p120GAP, IQGAP, Rab5-activating protein 6, and Neurofibromin. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213344 [Multi-domain]  Cd Length: 382  Bit Score: 51.07  E-value: 3.78e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2217369006 1311 GIPFLDYRTYTMRVLFPGIEDHPVLRDLEASVLDF 1345
Cdd:cd12205      1 GIPFLDFREYIIRVLFPGVNDHPVLLSKFVHGSRR 35
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1142-1226 2.85e-05

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 43.97  E-value: 2.85e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217369006 1142 PVFEAFGPSGIlELKPGTPIILKGKNLippvagGNVKLNYTVLVGEKPCTV-TVSDVQLLCESPNL-IGRHKVMARVGGM 1219
Cdd:pfam01833    1 PVITSISPSSG-PASGGTTITITGSNF------GTDSSDLKVTIGGTPCTViSVSSTTIVCTTPPGtSGLVNVSVTVGGG 73


                   ....*..
gi 2217369006 1220 EYSPGMV 1226
Cdd:pfam01833   74 GISSSPL 80
RasGAP_plexin_B1 cd12793
Ras-GTPase Activating Domain of plexin-B1; Plexins form a conserved family of transmembrane ...
 1311-1339 1.47e-04

Ras-GTPase Activating Domain of plexin-B1; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-B1 serves as the Semaphorin 4D receptor and functions as a regulator of developing neurons and a tumor suppressor protein for melanoma. The Sema4D and plexin-B1 signaling complex regulates dendritic and axonal complexity. The activation of Plexin-B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. As a tumor suppressor, plexin-B1 abrogates activation of the oncogenic receptor, c-Met, by its ligand, hepatocyte growth factor (HGF), in melanoma. Furthermore, plexin-B1 suppresses integrin-dependent migration and activation of pp125FAK and inhibits Rho activity. Plexin-B1 is highly expressed in endothelial cells and its activation by Sema4D elicits a potent proangiogenic response. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213353 [Multi-domain]  Cd Length: 394  Bit Score: 45.79  E-value: 1.47e-04
                           10        20
                   ....*....|....*....|....*....
gi 2217369006 1311 GIPFLDYRTYTMRVLFPGIEDHPVLRDLE 1339
Cdd:cd12793      1 GIPFLDYRMYAERIFFPGHRESPLRRDLD 29
PSI_integrin pfam17205
Integrin plexin domain; This short disulphide rich domain is found at the N-terminus of ...
 508-542 1.68e-04

Integrin plexin domain; This short disulphide rich domain is found at the N-terminus of integrin beta chains.


Pssm-ID: 465380  Cd Length: 47  Bit Score: 40.61  E-value: 1.68e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2217369006  508 ESC-GQYQSCGECLGSGdPHCGWCVLHNTCTRKERC 542
Cdd:pfam17205    1 NRCtSASTSCEECIQSG-PDCAWCTDENFTSGSPRC 35
RasGAP_plexin_B3 cd12791
Ras-GTPase Activating Domain of plexin-B3; Plexins form a conserved family of transmembrane ...
 1311-1339 1.72e-04

Ras-GTPase Activating Domain of plexin-B3; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-B3 is the receptor of semaphorin 5A. It is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin-B3 has been linked to verbal performance and white matter volume in human brain. Furthermore, Sema5A and plexin-B3 have been implicated in the progression of various types of cancer. They play an important role in the invasion and metastasis of gastric carcinoma. The protein and mRNA expression of Sema5A and its receptor plexin-B3 increased gradually in non-neoplastic mucosa, primary gastric carcinoma, and lymph node metastasis, and their expression is correlated. The stimulation of plexin-B3 by Sema5A binding in human glioma cells results in the inhibition of cell migration and invasion. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213351 [Multi-domain]  Cd Length: 397  Bit Score: 45.60  E-value: 1.72e-04
                           10        20
                   ....*....|....*....|....*....
gi 2217369006 1311 GIPFLDYRTYTMRVLFPGIEDHPVLRDLE 1339
Cdd:cd12791      1 GIPFLDYRTYAERVFFPGHGGCPLQPSLE 29
RasGAP_plexin_B cd12787
Ras-GTPase Activating Domain of type B plexins; Plexins form a conserved family of ...
 1311-1344 2.57e-04

Ras-GTPase Activating Domain of type B plexins; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity.There are three members of the Plexin-B subfamily, namely B1, B2 and B3. Plexins-B1, B2 and B3 are receptors for Sema4D, Sema4C and Sema4G, and Sema5A, respectively. The activation of plexin-B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. By signaling the effect of Sema4C and Sema4G, the plexin-B2 receptor is critically involved in neural tube closure and cerebellar granule cell development. Plexin-B3, the receptor of Sema5A, is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin-B3 has been linked to verbal performance and white matter volume in human brain. Small GTPases play important roles in plexin-B signaling. Plexin-B1 activates Rho through Rho-specific guanine nucleotide exchange factors, leading to neurite retraction. Plexin-B1 possesses an intrinsic GTPase-activating protein activity for R-Ras and induces growth cone collapse through R-Ras inactivation. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213347 [Multi-domain]  Cd Length: 391  Bit Score: 45.30  E-value: 2.57e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2217369006 1311 GIPFLDYRTYTMRVLFPGIEDHPVLRDLEASVLD 1344
Cdd:cd12787      1 GIPFLDYKTYAERVFFPGHKDGPLDVMIKLDIPE 34
IPT smart00429
ig-like, plexins, transcription factors;
1141-1204 3.42e-04

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 40.87  E-value: 3.42e-04
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217369006  1141 NPVFEAFGP-SGILElkPGTPIILKGKNLIPpvaGGNVKlnYTVLVGEKPCTVT-VSDVQLLCESP 1204
Cdd:smart00429    1 DPVITRISPtSGPVS--GGTEITLCGKNLKS---ISVVF--VEVGVGEAPCTFSpSSSTAIVCKTP 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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