SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain-containing protein may function as a protein-lysine N-methyltransferase, catalyzing the S-adenosyl-L-methionine (SAM)-dependent methylation at specific lysine residues of target proteins such as histones
SET domain found in SET domain-containing protein 6 (SETD6) and similar proteins; SETD6 is a ...
64-264
4.39e-95
SET domain found in SET domain-containing protein 6 (SETD6) and similar proteins; SETD6 is a lysine N-methyltransferase that monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF-kappa-B transcription factor activity. It also monomethylates 'Lys-8' of H2AZ (H2AZK8me1).
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Pssm-ID: 380955 [Multi-domain] Cd Length: 250 Bit Score: 280.35 E-value: 4.39e-95
SET domain found in SET domain-containing protein 6 (SETD6) and similar proteins; SETD6 is a ...
64-264
4.39e-95
SET domain found in SET domain-containing protein 6 (SETD6) and similar proteins; SETD6 is a lysine N-methyltransferase that monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF-kappa-B transcription factor activity. It also monomethylates 'Lys-8' of H2AZ (H2AZK8me1).
Pssm-ID: 380955 [Multi-domain] Cd Length: 250 Bit Score: 280.35 E-value: 4.39e-95
SET domain found in SET domain-containing protein 6 (SETD6) and similar proteins; SETD6 is a ...
64-264
4.39e-95
SET domain found in SET domain-containing protein 6 (SETD6) and similar proteins; SETD6 is a lysine N-methyltransferase that monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF-kappa-B transcription factor activity. It also monomethylates 'Lys-8' of H2AZ (H2AZK8me1).
Pssm-ID: 380955 [Multi-domain] Cd Length: 250 Bit Score: 280.35 E-value: 4.39e-95
SET domain found in Rubisco large subunit methyltransferase (LSMT) and similar proteins; ...
68-263
7.43e-28
SET domain found in Rubisco large subunit methyltransferase (LSMT) and similar proteins; Rubisco LSMT is a non-histone protein methyl transferase responsible for the trimethylation of lysine14 in the large subunit of Rubisco (ribulose-1,5-bisphosphate carboxylase/oxygenase). The family also includes SET domain-containing proteins, SETD3, SETD4 and SETD6, which belong to methyltransferase class VII that represents classical non-histone SET domain methyltransferases. Members in this family contain a SET domain and a C-terminal RubisCO LSMT substrate-binding (Rubis-subs-bind) domain.
Pssm-ID: 380925 [Multi-domain] Cd Length: 236 Bit Score: 107.54 E-value: 7.43e-28
SET domain found in chloroplastic ribulose-1,5 bisphosphate carboxylase/oxygenase large ...
61-277
1.07e-20
SET domain found in chloroplastic ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase (RBCMT) and similar proteins; RBCMT (EC 2.1.1.127; also termed [Ribulose-bisphosphate carboxylase]-lysine N-methyltransferase, RuBisCO LSMT, RuBisCO methyltransferase, or rbcMT) methylates 'Lys-14' of the large subunit of RuBisCO.
Pssm-ID: 380956 Cd Length: 237 Bit Score: 88.14 E-value: 1.07e-20
SET domain found in Schizosaccharomyces pombe SET domain-containing protein 10 (SETD10) and ...
68-252
3.41e-13
SET domain found in Schizosaccharomyces pombe SET domain-containing protein 10 (SETD10) and similar proteins; Schizosaccharomyces pombe SETD10 is a ribosomal S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates ribosomal protein L23 (rpl23a and rpl23b).
Pssm-ID: 380957 Cd Length: 252 Bit Score: 67.75 E-value: 3.41e-13
SET domain found in SET domain-containing protein 4 (SETD4) and similar proteins; SETD4 is a ...
73-263
4.72e-08
SET domain found in SET domain-containing protein 4 (SETD4) and similar proteins; SETD4 is a cytosolic and nuclear functional lysine methyltransferase that plays a crucial role in breast carcinogenesis. However, its specific substrates and modification sites remain to be disclosed.
Pssm-ID: 380954 [Multi-domain] Cd Length: 245 Bit Score: 52.69 E-value: 4.72e-08
SET domain found in SET domain-containing protein 3 (SETD3) and similar proteins; SETD3 (EC 2. ...
74-265
7.77e-08
SET domain found in SET domain-containing protein 3 (SETD3) and similar proteins; SETD3 (EC 2.1.1.43) is a histone-lysine N-methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3 (H3K4me and H3K36me). It functions as a transcriptional activator that plays an important role in the transcriptional regulation of muscle cell differentiation via interaction with MYOD1.
Pssm-ID: 380953 Cd Length: 251 Bit Score: 52.26 E-value: 7.77e-08
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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