serine/threonine-protein kinase RIO3 isoform X1 [Homo sapiens]
Protein Classification
protein kinase family protein( domain architecture ID 229378)
protein kinase family protein may catalyze the transfer of the gamma-phosphoryl group from ATP to substrates such as serine/threonine and/or tyrosine residues on proteins, or may be a pseudokinase
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| PKc_like super family | cl21453 | Protein Kinases, catalytic domain; The protein kinase superfamily is mainly composed of the ... |
222-291 | 9.68e-17 | ||
Protein Kinases, catalytic domain; The protein kinase superfamily is mainly composed of the catalytic domains of serine/threonine-specific and tyrosine-specific protein kinases. It also includes RIO kinases, which are atypical serine protein kinases, aminoglycoside phosphotransferases, and choline kinases. These proteins catalyze the transfer of the gamma-phosphoryl group from ATP to hydroxyl groups in specific substrates such as serine, threonine, or tyrosine residues of proteins. The actual alignment was detected with superfamily member smart00090: Pssm-ID: 473864 [Multi-domain] Cd Length: 237 Bit Score: 77.73 E-value: 9.68e-17
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| Name | Accession | Description | Interval | E-value | ||
| RIO | smart00090 | RIO-like kinase; |
222-291 | 9.68e-17 | ||
RIO-like kinase; Pssm-ID: 214511 [Multi-domain] Cd Length: 237 Bit Score: 77.73 E-value: 9.68e-17
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| RIO3_euk | cd05146 | Catalytic domain of the atypical protein serine kinase, RIO3 kinase; RIO3 is present only in ... |
253-290 | 7.85e-13 | ||
Catalytic domain of the atypical protein serine kinase, RIO3 kinase; RIO3 is present only in multicellular eukaryotes. It is associated with precursors of 40S ribosomal subunits, just like RIO1 and RIO2. Its specific function is still unknown. Like RIO1 and RIO2, it may be involved in ribosomal subunit processing and maturation. RIO kinases are atypical protein serine kinases containing a kinase catalytic signature, but otherwise show very little sequence similarity to typical PKs. Serine kinases catalyze the transfer of the gamma-phosphoryl group from ATP to serine residues in protein substrates. The RIO catalytic domain is truncated compared to the catalytic domains of typical PKs, with deletions of the loops responsible for substrate binding. The RIO3 kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K). Pssm-ID: 270697 Cd Length: 196 Bit Score: 66.23 E-value: 7.85e-13
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| RIO1 | COG1718 | Serine/threonine-protein kinase RIO1 [Signal transduction mechanisms]; |
214-271 | 5.64e-04 | ||
Serine/threonine-protein kinase RIO1 [Signal transduction mechanisms]; Pssm-ID: 441324 Cd Length: 252 Bit Score: 40.56 E-value: 5.64e-04
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| Name | Accession | Description | Interval | E-value | ||
| RIO | smart00090 | RIO-like kinase; |
222-291 | 9.68e-17 | ||
RIO-like kinase; Pssm-ID: 214511 [Multi-domain] Cd Length: 237 Bit Score: 77.73 E-value: 9.68e-17
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| RIO3_euk | cd05146 | Catalytic domain of the atypical protein serine kinase, RIO3 kinase; RIO3 is present only in ... |
253-290 | 7.85e-13 | ||
Catalytic domain of the atypical protein serine kinase, RIO3 kinase; RIO3 is present only in multicellular eukaryotes. It is associated with precursors of 40S ribosomal subunits, just like RIO1 and RIO2. Its specific function is still unknown. Like RIO1 and RIO2, it may be involved in ribosomal subunit processing and maturation. RIO kinases are atypical protein serine kinases containing a kinase catalytic signature, but otherwise show very little sequence similarity to typical PKs. Serine kinases catalyze the transfer of the gamma-phosphoryl group from ATP to serine residues in protein substrates. The RIO catalytic domain is truncated compared to the catalytic domains of typical PKs, with deletions of the loops responsible for substrate binding. The RIO3 kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K). Pssm-ID: 270697 Cd Length: 196 Bit Score: 66.23 E-value: 7.85e-13
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| RIO1_like | cd05145 | Catalytic domain of the atypical protein serine kinases, RIO1 and RIO3 kinases and similar ... |
253-290 | 5.46e-04 | ||
Catalytic domain of the atypical protein serine kinases, RIO1 and RIO3 kinases and similar proteins; RIO1 is present in archaea, bacteria and eukaryotes. In addition, RIO3 is present in multicellular eukaryotes. Both RIO1 and RIO3 are associated with precursors of 40S ribosomal subunits, just like RIO2. RIO1 is essential for survival and is required for 18S rRNA processing, proper cell cycle progression and chromosome maintenance. Although depletion of either RIO1 and RIO2 results in similar effects, the two kinases are not fully interchangeable. The specific function of RIO3 is unknown. RIO kinases are atypical protein serine kinases containing a kinase catalytic signature, but otherwise show very little sequence similarity to typical PKs. Serine kinases catalyze the transfer of the gamma-phosphoryl group from ATP to serine residues in protein substrates. The RIO catalytic domain is truncated compared to the catalytic domains of typical PKs, with deletions of the loops responsible for substrate binding. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K). Pssm-ID: 270696 [Multi-domain] Cd Length: 189 Bit Score: 40.23 E-value: 5.46e-04
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| RIO1 | COG1718 | Serine/threonine-protein kinase RIO1 [Signal transduction mechanisms]; |
214-271 | 5.64e-04 | ||
Serine/threonine-protein kinase RIO1 [Signal transduction mechanisms]; Pssm-ID: 441324 Cd Length: 252 Bit Score: 40.56 E-value: 5.64e-04
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| RIO1_euk | cd05147 | Catalytic domain of the atypical protein serine kinase, Eukaryotic RIO1 kinase; RIO1 is ... |
253-275 | 7.27e-03 | ||
Catalytic domain of the atypical protein serine kinase, Eukaryotic RIO1 kinase; RIO1 is present in archaea, bacteria and eukaryotes. This subfamily is composed of RIO1 proteins from eukaryotes. RIO1 is essential for survival and is required for 18S rRNA processing, proper cell cycle progression and chromosome maintenance. It is associated with precursors of 40S ribosomal subunits, just like RIO2. Although depletion of either RIO1 and RIO2 results in similar effects, the two kinases are not fully interchangeable. RIO kinases are atypical protein serine kinases containing a kinase catalytic signature, but otherwise show very little sequence similarity to typical PKs. Serine kinases catalyze the transfer of the gamma-phosphoryl group from ATP to serine residues in protein substrates. The RIO catalytic domain is truncated compared to the catalytic domains of typical PKs, with deletions of the loops responsible for substrate binding. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K). Pssm-ID: 270698 Cd Length: 190 Bit Score: 36.78 E-value: 7.27e-03
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