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Conserved domains on  [gi|2217320276|ref|XP_047294481|]
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HAUS augmin-like complex subunit 5 isoform X3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
HAUS5 super family cl25643
HAUS augmin-like complex subunit 5; This family includes HAUS augmin-like complex subunit 5. ...
7-274 3.86e-109

HAUS augmin-like complex subunit 5; This family includes HAUS augmin-like complex subunit 5. The HAUS augmin-like complex contributes to mitotic spindle assembly, maintenance of chromosome integrity and completion of cytokinesis.


The actual alignment was detected with superfamily member pfam14817:

Pssm-ID: 464332 [Multi-domain]  Cd Length: 643  Bit Score: 329.70  E-value: 3.86e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217320276   7 ARELGCWAVEEMGVPVAARAPESTLRRLCLGQGADIWAYILQHVHSQRTVKKIRGNLLWYG--------HQDSPQVRRKL 78
Cdd:pfam14817   1 AEELKRWAQEEMGYPPSALPSDSYLRTLCRGNGAPIWKYLIQHVKSERNVRKIRGNLLWYGglqdkgkaESRQSAAARRL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217320276  79 ELEAAVTRLRAEIQELDQSLELMERDTEAQDTAMEQARQHTQDTQRRALLLRAQAGAMRRQQHTLRDPMQRLQNQLRRLQ 158
Cdd:pfam14817  81 ELQKEIERLRAEISRLDKQLEARELELSREEAERERALDEISDSRHRQLLLEAYDQQCEEARKILAEDHQRLQGQLQQLR 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217320276 159 DMERKAKVDVTFGSLTSAA---LGLEPVVLRDVRTACTLRAQFLQNLLLPQAKRGSLPTPH--DDHFGTSYQQWLSSVET 233
Cdd:pfam14817 161 DAARKAEKEVVFGDSKGSKssvIALEPQVLRDVREACELRAQFLQELLESSLKAYEGSGIHmnRDQRRAVIQHWLSAVET 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 2217320276 234 LLTNHPPGHVLAALEHLAAEREAEIRSLCSG-DGLGDTEISR 274
Cdd:pfam14817 241 LLTSHPPSHLLQALEHLAAREKTAIQEETESlDVRADAEALR 282
 
Name Accession Description Interval E-value
HAUS5 pfam14817
HAUS augmin-like complex subunit 5; This family includes HAUS augmin-like complex subunit 5. ...
7-274 3.86e-109

HAUS augmin-like complex subunit 5; This family includes HAUS augmin-like complex subunit 5. The HAUS augmin-like complex contributes to mitotic spindle assembly, maintenance of chromosome integrity and completion of cytokinesis.


Pssm-ID: 464332 [Multi-domain]  Cd Length: 643  Bit Score: 329.70  E-value: 3.86e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217320276   7 ARELGCWAVEEMGVPVAARAPESTLRRLCLGQGADIWAYILQHVHSQRTVKKIRGNLLWYG--------HQDSPQVRRKL 78
Cdd:pfam14817   1 AEELKRWAQEEMGYPPSALPSDSYLRTLCRGNGAPIWKYLIQHVKSERNVRKIRGNLLWYGglqdkgkaESRQSAAARRL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217320276  79 ELEAAVTRLRAEIQELDQSLELMERDTEAQDTAMEQARQHTQDTQRRALLLRAQAGAMRRQQHTLRDPMQRLQNQLRRLQ 158
Cdd:pfam14817  81 ELQKEIERLRAEISRLDKQLEARELELSREEAERERALDEISDSRHRQLLLEAYDQQCEEARKILAEDHQRLQGQLQQLR 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217320276 159 DMERKAKVDVTFGSLTSAA---LGLEPVVLRDVRTACTLRAQFLQNLLLPQAKRGSLPTPH--DDHFGTSYQQWLSSVET 233
Cdd:pfam14817 161 DAARKAEKEVVFGDSKGSKssvIALEPQVLRDVREACELRAQFLQELLESSLKAYEGSGIHmnRDQRRAVIQHWLSAVET 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 2217320276 234 LLTNHPPGHVLAALEHLAAEREAEIRSLCSG-DGLGDTEISR 274
Cdd:pfam14817 241 LLTSHPPSHLLQALEHLAAREKTAIQEETESlDVRADAEALR 282
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
76-238 1.22e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 43.51  E-value: 1.22e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217320276   76 RKLELEAAVTRLRAEIQELDQSLELMERDTEAQDTAMEQARQHTQDTQRRALLLRAQAGAMRRQQHTLRDPMQRLQNQLR 155
Cdd:TIGR02168  345 KLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIE 424
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217320276  156 RLQDMERKAKVDVTFGSLTSAALGLEPVVLRD---VRTACTLRAQFLQNLLLPQAKRGSLptphddhfgTSYQQWLSSVE 232
Cdd:TIGR02168  425 ELLKKLEEAELKELQAELEELEEELEELQEELerlEEALEELREELEEAEQALDAAEREL---------AQLQARLDSLE 495

                   ....*.
gi 2217320276  233 TLLTNH 238
Cdd:TIGR02168  496 RLQENL 501
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
75-158 4.90e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 38.36  E-value: 4.90e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217320276   75 RRKLELEAAVTRLRAEIQELDQSLELMERDTEAQDTAMEQAR-QHTQDTQRRALLLRAQAGAMRRQQHTLRDPMQRLQNQ 153
Cdd:COG4913    288 RRLELLEAELEELRAELARLEAELERLEARLDALREELDELEaQIRGNGGDRLEQLEREIERLERELEERERRRARLEAL 367

                   ....*
gi 2217320276  154 LRRLQ 158
Cdd:COG4913    368 LAALG 372
 
Name Accession Description Interval E-value
HAUS5 pfam14817
HAUS augmin-like complex subunit 5; This family includes HAUS augmin-like complex subunit 5. ...
7-274 3.86e-109

HAUS augmin-like complex subunit 5; This family includes HAUS augmin-like complex subunit 5. The HAUS augmin-like complex contributes to mitotic spindle assembly, maintenance of chromosome integrity and completion of cytokinesis.


Pssm-ID: 464332 [Multi-domain]  Cd Length: 643  Bit Score: 329.70  E-value: 3.86e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217320276   7 ARELGCWAVEEMGVPVAARAPESTLRRLCLGQGADIWAYILQHVHSQRTVKKIRGNLLWYG--------HQDSPQVRRKL 78
Cdd:pfam14817   1 AEELKRWAQEEMGYPPSALPSDSYLRTLCRGNGAPIWKYLIQHVKSERNVRKIRGNLLWYGglqdkgkaESRQSAAARRL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217320276  79 ELEAAVTRLRAEIQELDQSLELMERDTEAQDTAMEQARQHTQDTQRRALLLRAQAGAMRRQQHTLRDPMQRLQNQLRRLQ 158
Cdd:pfam14817  81 ELQKEIERLRAEISRLDKQLEARELELSREEAERERALDEISDSRHRQLLLEAYDQQCEEARKILAEDHQRLQGQLQQLR 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217320276 159 DMERKAKVDVTFGSLTSAA---LGLEPVVLRDVRTACTLRAQFLQNLLLPQAKRGSLPTPH--DDHFGTSYQQWLSSVET 233
Cdd:pfam14817 161 DAARKAEKEVVFGDSKGSKssvIALEPQVLRDVREACELRAQFLQELLESSLKAYEGSGIHmnRDQRRAVIQHWLSAVET 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 2217320276 234 LLTNHPPGHVLAALEHLAAEREAEIRSLCSG-DGLGDTEISR 274
Cdd:pfam14817 241 LLTSHPPSHLLQALEHLAAREKTAIQEETESlDVRADAEALR 282
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
76-238 1.22e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 43.51  E-value: 1.22e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217320276   76 RKLELEAAVTRLRAEIQELDQSLELMERDTEAQDTAMEQARQHTQDTQRRALLLRAQAGAMRRQQHTLRDPMQRLQNQLR 155
Cdd:TIGR02168  345 KLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIE 424
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217320276  156 RLQDMERKAKVDVTFGSLTSAALGLEPVVLRD---VRTACTLRAQFLQNLLLPQAKRGSLptphddhfgTSYQQWLSSVE 232
Cdd:TIGR02168  425 ELLKKLEEAELKELQAELEELEEELEELQEELerlEEALEELREELEEAEQALDAAEREL---------AQLQARLDSLE 495

                   ....*.
gi 2217320276  233 TLLTNH 238
Cdd:TIGR02168  496 RLQENL 501
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
75-158 4.90e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 38.36  E-value: 4.90e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217320276   75 RRKLELEAAVTRLRAEIQELDQSLELMERDTEAQDTAMEQAR-QHTQDTQRRALLLRAQAGAMRRQQHTLRDPMQRLQNQ 153
Cdd:COG4913    288 RRLELLEAELEELRAELARLEAELERLEARLDALREELDELEaQIRGNGGDRLEQLEREIERLERELEERERRRARLEAL 367

                   ....*
gi 2217320276  154 LRRLQ 158
Cdd:COG4913    368 LAALG 372
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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