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Conserved domains on  [gi|2217339095|ref|XP_047297137|]
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DNA-directed RNA polymerase III subunit RPC8 isoform X2 [Homo sapiens]

Protein Classification

RNA_pol_Rbc25 domain-containing protein( domain architecture ID 10550642)

RNA_pol_Rbc25 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RNA_pol_Rbc25 pfam08292
RNA polymerase III subunit Rpc25; Rpc25 is a strongly conserved subunit of RNA polymerase III ...
 33-138 4.73e-49

RNA polymerase III subunit Rpc25; Rpc25 is a strongly conserved subunit of RNA polymerase III and has homology to Rpa43 in RNA polymerase I, Rpb7 in RNA polymerase II and the archaeal RpoE subunit. Rpc25 is required for transcription initiation and is not essential for the elongating properties of RNA polymerase III.


:

Pssm-ID: 400543  Cd Length: 121  Bit Score: 153.21  E-value: 4.73e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217339095  33 GAGVSLGFFDDILIPPESLQQPAKFDEAEQVWVWEYETEegaHDLYMDTGEEIRFRVVDESFVDTSPTGPSSADATT--- 109
Cdd:pfam08292  14 GIKVSLGFFDDIFVPPDLLFEPSEFDEEEQAWVWEYDEE---TELYFDVGEEIRFRVEQEIFVDVKPTSPKLAELTSesl 90

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2217339095 110 --SSEELPKKEAPYTLVGSISEPGLGLLSWW 138
Cdd:pfam08292  91 aeSEEEIPEKKPPYELIGSCQEDGLGLVSWW 121
 
Name Accession Description Interval E-value
RNA_pol_Rbc25 pfam08292
RNA polymerase III subunit Rpc25; Rpc25 is a strongly conserved subunit of RNA polymerase III ...
 33-138 4.73e-49

RNA polymerase III subunit Rpc25; Rpc25 is a strongly conserved subunit of RNA polymerase III and has homology to Rpa43 in RNA polymerase I, Rpb7 in RNA polymerase II and the archaeal RpoE subunit. Rpc25 is required for transcription initiation and is not essential for the elongating properties of RNA polymerase III.


Pssm-ID: 400543  Cd Length: 121  Bit Score: 153.21  E-value: 4.73e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217339095  33 GAGVSLGFFDDILIPPESLQQPAKFDEAEQVWVWEYETEegaHDLYMDTGEEIRFRVVDESFVDTSPTGPSSADATT--- 109
Cdd:pfam08292  14 GIKVSLGFFDDIFVPPDLLFEPSEFDEEEQAWVWEYDEE---TELYFDVGEEIRFRVEQEIFVDVKPTSPKLAELTSesl 90

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2217339095 110 --SSEELPKKEAPYTLVGSISEPGLGLLSWW 138
Cdd:pfam08292  91 aeSEEEIPEKKPPYELIGSCQEDGLGLVSWW 121
rpoE TIGR00448
DNA-directed RNA polymerase (rpoE), archaeal and eukaryotic form; This family seems to be ...
 33-101 2.08e-10

DNA-directed RNA polymerase (rpoE), archaeal and eukaryotic form; This family seems to be confined to the archea and eukaryotic taxa and are quite dissimilar to E.coli rpoE. [Transcription, DNA-dependent RNA polymerase]


Pssm-ID: 129540 [Multi-domain]  Cd Length: 179  Bit Score: 55.56  E-value: 2.08e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217339095  33 GAGVSLGFFDDILIPPESLQQPAKFDEAEQVWVWEyETEegahdLYMDTGEEIRFRVVDESFVDTSPTG 101
Cdd:TIGR00448  96 GAFVSLGPFDGLFHVSQVTDDYCYYDPKESALIGK-ETK-----KVLDEGDKVRARIVALSLKDRRPEG 158
 
Name Accession Description Interval E-value
RNA_pol_Rbc25 pfam08292
RNA polymerase III subunit Rpc25; Rpc25 is a strongly conserved subunit of RNA polymerase III ...
 33-138 4.73e-49

RNA polymerase III subunit Rpc25; Rpc25 is a strongly conserved subunit of RNA polymerase III and has homology to Rpa43 in RNA polymerase I, Rpb7 in RNA polymerase II and the archaeal RpoE subunit. Rpc25 is required for transcription initiation and is not essential for the elongating properties of RNA polymerase III.


Pssm-ID: 400543  Cd Length: 121  Bit Score: 153.21  E-value: 4.73e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217339095  33 GAGVSLGFFDDILIPPESLQQPAKFDEAEQVWVWEYETEegaHDLYMDTGEEIRFRVVDESFVDTSPTGPSSADATT--- 109
Cdd:pfam08292  14 GIKVSLGFFDDIFVPPDLLFEPSEFDEEEQAWVWEYDEE---TELYFDVGEEIRFRVEQEIFVDVKPTSPKLAELTSesl 90

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2217339095 110 --SSEELPKKEAPYTLVGSISEPGLGLLSWW 138
Cdd:pfam08292  91 aeSEEEIPEKKPPYELIGSCQEDGLGLVSWW 121
rpoE TIGR00448
DNA-directed RNA polymerase (rpoE), archaeal and eukaryotic form; This family seems to be ...
 33-101 2.08e-10

DNA-directed RNA polymerase (rpoE), archaeal and eukaryotic form; This family seems to be confined to the archea and eukaryotic taxa and are quite dissimilar to E.coli rpoE. [Transcription, DNA-dependent RNA polymerase]


Pssm-ID: 129540 [Multi-domain]  Cd Length: 179  Bit Score: 55.56  E-value: 2.08e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217339095  33 GAGVSLGFFDDILIPPESLQQPAKFDEAEQVWVWEyETEegahdLYMDTGEEIRFRVVDESFVDTSPTG 101
Cdd:TIGR00448  96 GAFVSLGPFDGLFHVSQVTDDYCYYDPKESALIGK-ETK-----KVLDEGDKVRARIVALSLKDRRPEG 158
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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