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Conserved domains on  [gi|2217348599|ref|XP_047305468|]
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protein transport protein Sec24B isoform X3 [Homo sapiens]

Protein Classification

SEC24 family transport protein( domain architecture ID 1001573)

SEC24 family transport protein is a component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5028 super family cl34873
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking ...
 526-1231 0e+00

Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5028:

Pssm-ID: 227361 [Multi-domain]  Cd Length: 861  Bit Score: 564.80  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599  526 NCSPDSFRCTLTNIPQTQALLNKAKLPLGLLLHPFRDLT----QLPVITSNTIVRCRSCRTYINPFVSFIDQ-RRWKCNL 600
Cdd:COG5028    147 NCSPKYVRSTMYAIPETNDLLKKSKIPFGLVIRPFLELYpeedPVPLVEDGSIVRCRRCRSYINPFVQFIEQgRKWRCNI 226

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599  601 CYRVNDVPEEFmYNPLTRS--YGEPHKRPEVQNSTVEFIASSDYMLRPPQPAVYLFVLDVSHNAVEAGYLTILCQSLLEN 678
Cdd:COG5028    227 CRSKNDVPEGF-DNPSGPNdpRSDRYSRPELKSGVVDFLAPKEYSLRQPPPPVYVFLIDVSFEAIKNGLVKAAIRAILEN 305

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599  679 LDKLPG-DSRTRIGFMTFDSTIHFYNLQEGLSQpQMLIVSDIDDVFLPTP-DSLLVNLYESKELIKDLLNALPNMFTNTR 756
Cdd:COG5028    306 LDQIPNfDPRTKIAIICFDSSLHFFKLSPDLDE-QMLIVSDLDEPFLPFPsGLFVLPLKSCKQIIETLLDRVPRIFQDNK 384

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599  757 ETHSALGPALQAAFKLMSPTGGRVSVFQTQLPSLGAGLLQSREDPNQRsstkvvqHLGPATDFYKKLALDCSGQQTAVDL 836
Cdd:COG5028    385 SPKNALGPALKAAKSLIGGTGGKIIVFLSTLPNMGIGKLQLREDKESS-------LLSCKDSFYKEFAIECSKVGISVDL 457

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599  837 FLLSSQYSDLASLACMSKYSAGCIYYYPSFHYThNPSQAEKLQKDLKRYLTRKIGFEAVMRIRCTKGLSMHTFHGNFFVR 916
Cdd:COG5028    458 FLTSEDYIDVATLSHLCRYTGGQTYFYPNFSAT-RPNDATKLANDLVSHLSMEIGYEAVMRVRCSTGLRVSSFYGNFFNR 536

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599  917 STDLLSLANINPDAGFAVQLSIEESLTdTSLVCFQTALLYTSSKGERRIRVHTLCLPVVSSLADVYAGVDVQAAICLLAN 996
Cdd:COG5028    537 SSDLCAFSTMPRDTSLLVEFSIDEKLM-TSDVYFQVALLYTLNDGERRIRVVNLSLPTSSSIREVYASADQLAIACILAK 615

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599  997 MAVDRSVSSSLSDARDALVNAVVDSLSAY-GSTVSNLQHSALMAPSSLKLFPLYVLALLKQKAFRTGtSTRLDDRVYAMC 1075
Cdd:COG5028    616 KASTKALNSSLKEARVLINKSMVDILKAYkKELVKSNTSTQLPLPANLKLLPLLMLALLKSSAFRSG-STPSDIRISALN 694

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599 1076 QIKSQPLVHLMKMIHPNLYRIDRLTDEGAVHVNDRIVPQPPLqKLSAEKLTREGAFLMDCGSVFYIWVGKGCDNNFIEDV 1155
Cdd:COG5028    695 RLTSLPLKQLMRNIYPTLYALHDMPIEAGLPDEGLLVLPSPI-NATSSLLESGGLYLIDTGQKIFLWFGKDAVPSLLQDL 773

                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217348599 1156 LGYTNFASIPQKMTHLPELDTLSSERARSFITWLRDSRP-LSPILHIVKD--ESPAKAEFFQHLIEDRTEAAFSYYEFL 1231
Cdd:COG5028    774 FGVDSLSDIPSGKFTLPPTGNEFNERVRNIIGELRSVNDdSTLPLVLVRGggDPSLRLWFFSTLVEDKTLNIPSYLDYL 852
 
Name Accession Description Interval E-value
COG5028 COG5028
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking ...
 526-1231 0e+00

Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion];


Pssm-ID: 227361 [Multi-domain]  Cd Length: 861  Bit Score: 564.80  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599  526 NCSPDSFRCTLTNIPQTQALLNKAKLPLGLLLHPFRDLT----QLPVITSNTIVRCRSCRTYINPFVSFIDQ-RRWKCNL 600
Cdd:COG5028    147 NCSPKYVRSTMYAIPETNDLLKKSKIPFGLVIRPFLELYpeedPVPLVEDGSIVRCRRCRSYINPFVQFIEQgRKWRCNI 226

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599  601 CYRVNDVPEEFmYNPLTRS--YGEPHKRPEVQNSTVEFIASSDYMLRPPQPAVYLFVLDVSHNAVEAGYLTILCQSLLEN 678
Cdd:COG5028    227 CRSKNDVPEGF-DNPSGPNdpRSDRYSRPELKSGVVDFLAPKEYSLRQPPPPVYVFLIDVSFEAIKNGLVKAAIRAILEN 305

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599  679 LDKLPG-DSRTRIGFMTFDSTIHFYNLQEGLSQpQMLIVSDIDDVFLPTP-DSLLVNLYESKELIKDLLNALPNMFTNTR 756
Cdd:COG5028    306 LDQIPNfDPRTKIAIICFDSSLHFFKLSPDLDE-QMLIVSDLDEPFLPFPsGLFVLPLKSCKQIIETLLDRVPRIFQDNK 384

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599  757 ETHSALGPALQAAFKLMSPTGGRVSVFQTQLPSLGAGLLQSREDPNQRsstkvvqHLGPATDFYKKLALDCSGQQTAVDL 836
Cdd:COG5028    385 SPKNALGPALKAAKSLIGGTGGKIIVFLSTLPNMGIGKLQLREDKESS-------LLSCKDSFYKEFAIECSKVGISVDL 457

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599  837 FLLSSQYSDLASLACMSKYSAGCIYYYPSFHYThNPSQAEKLQKDLKRYLTRKIGFEAVMRIRCTKGLSMHTFHGNFFVR 916
Cdd:COG5028    458 FLTSEDYIDVATLSHLCRYTGGQTYFYPNFSAT-RPNDATKLANDLVSHLSMEIGYEAVMRVRCSTGLRVSSFYGNFFNR 536

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599  917 STDLLSLANINPDAGFAVQLSIEESLTdTSLVCFQTALLYTSSKGERRIRVHTLCLPVVSSLADVYAGVDVQAAICLLAN 996
Cdd:COG5028    537 SSDLCAFSTMPRDTSLLVEFSIDEKLM-TSDVYFQVALLYTLNDGERRIRVVNLSLPTSSSIREVYASADQLAIACILAK 615

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599  997 MAVDRSVSSSLSDARDALVNAVVDSLSAY-GSTVSNLQHSALMAPSSLKLFPLYVLALLKQKAFRTGtSTRLDDRVYAMC 1075
Cdd:COG5028    616 KASTKALNSSLKEARVLINKSMVDILKAYkKELVKSNTSTQLPLPANLKLLPLLMLALLKSSAFRSG-STPSDIRISALN 694

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599 1076 QIKSQPLVHLMKMIHPNLYRIDRLTDEGAVHVNDRIVPQPPLqKLSAEKLTREGAFLMDCGSVFYIWVGKGCDNNFIEDV 1155
Cdd:COG5028    695 RLTSLPLKQLMRNIYPTLYALHDMPIEAGLPDEGLLVLPSPI-NATSSLLESGGLYLIDTGQKIFLWFGKDAVPSLLQDL 773

                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217348599 1156 LGYTNFASIPQKMTHLPELDTLSSERARSFITWLRDSRP-LSPILHIVKD--ESPAKAEFFQHLIEDRTEAAFSYYEFL 1231
Cdd:COG5028    774 FGVDSLSDIPSGKFTLPPTGNEFNERVRNIIGELRSVNDdSTLPLVLVRGggDPSLRLWFFSTLVEDKTLNIPSYLDYL 852
Sec24-like cd01479
Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the ...
 647-890 1.02e-131

Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes of vesicular carriers within the endocytic and the biosynthetic pathways are COP- and clathrin-coated vesicles. Formation of COPII vesicles requires the ordered assembly of the coat built from several cytosolic components GTPase Sar1, complexes of Sec23-Sec24 and Sec13-Sec31. The process is initiated by the conversion of GDP to GTP by the GTPase Sar1 which then recruits the heterodimeric complex of Sec23 and Sec24. This heterodimeric complex generates the pre-budding complex. The final step leading to membrane deformation and budding of COPII-coated vesicles is carried by the heterodimeric complex Sec13-Sec31. The members of this CD belong to the Sec23-like family. Sec 24 is very similar to Sec23. The Sec23 and Sec24 polypeptides fold into five distinct domains: a beta-barrel, a zinc finger, a vWA or trunk, an all helical region and a carboxy Gelsolin domain. The members of this subgroup carry a partial MIDAS motif and have the overall Para-Rossmann type fold that is characteristic of this superfamily.


Pssm-ID: 238756 [Multi-domain]  Cd Length: 244  Bit Score: 402.81  E-value: 1.02e-131
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599  647 PQPAVYLFVLDVSHNAVEAGYLTILCQSLLENLDKLPGD-SRTRIGFMTFDSTIHFYNLQEGLSQPQMLIVSDIDDVFLP 725
Cdd:cd01479      1 PQPAVYVFLIDVSYNAIKSGLLATACEALLSNLDNLPGDdPRTRVGFITFDSTLHFFNLKSSLEQPQMMVVSDLDDPFLP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599  726 TPDSLLVNLYESKELIKDLLNALPNMFTNTRETHSALGPALQAAFKLMSPTGGRVSVFQTQLPSLGAGLLQSREDPNQRS 805
Cdd:cd01479     81 LPDGLLVNLKESRQVIEDLLDQIPEMFQDTKETESALGPALQAAFLLLKETGGKIIVFQSSLPTLGAGKLKSREDPKLLS 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599  806 STKVVQHLGPATDFYKKLALDCSGQQTAVDLFLLSSQYSDLASLACMSKYSAGCIYYYPSFHyTHNPSQAEKLQKDLKRY 885
Cdd:cd01479    161 TDKEKQLLQPQTDFYKKLALECVKSQISVDLFLFSNQYVDVATLGCLSRLTGGQVYYYPSFN-FSAPNDVEKLVNELARY 239


                   ....*
gi 2217348599  886 LTRKI 890
Cdd:cd01479    240 LTRKI 244
Sec23_trunk pfam04811
Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum ...
 647-886 1.04e-107

Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is known as the trunk domain and has an alpha/beta vWA fold and forms the dimer interface.


Pssm-ID: 398467 [Multi-domain]  Cd Length: 241  Bit Score: 338.46  E-value: 1.04e-107
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599  647 PQPAVYLFVLDVSHNAVEAGYLTILCQSLLENLDKLPGDSRTRIGFMTFDSTIHFYNLQEGLSQPQMLIVSDIDDVFLPT 726
Cdd:pfam04811    1 PQPPVFLFVIDVSYNAIKSGLLAALKESLLQSLDLLPGDPRARVGFITFDSTVHFFNLGSSLRQPQMLVVSDLQDMFLPL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599  727 PDSLLVNLYESKELIKDLLNALPNMFTNTRETHSALGPALQAAFKLM--SPTGGRVSVFQTQLPSLGA-GLLQSREDPNQ 803
Cdd:pfam04811   81 PDRFLVPLSECRFVLEDLLEQLPPMFPVTKRPERCLGPALQAAFLLLkaAFTGGKIMVFQGGLPTVGPgGKLKSRLDESH 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599  804 RSSTKVVQHLGPATD-FYKKLALDCSGQQTAVDLFLLSSQYSDLASLACMSKYSAGCIYYYPSFHYTHnpsQAEKLQKDL 882
Cdd:pfam04811  161 HGTDKEKAKLVKKADkFYKSLAKECVKQGHSVDLFAFSLDYVDVATLGQLSRLTGGQVYLYPSFQADV---DGSKFKQDL 237


                   ....
gi 2217348599  883 KRYL 886
Cdd:pfam04811  238 QRYF 241
PTZ00395 PTZ00395
Sec24-related protein; Provisional
 612-1240 3.50e-44

Sec24-related protein; Provisional


Pssm-ID: 185594 [Multi-domain]  Cd Length: 1560  Bit Score: 175.65  E-value: 3.50e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599  612 MYNPLTRSYGEPHKRPEVQNStvefiassdYMLRPPQ-----PAVYLFVLDVSHNAVEAGYLTILCQSL---LENLdKLP 683
Cdd:PTZ00395   919 MKNLICEKNGEPDSAKIRRNS---------FLAKYPQvknmlPPYFVFVVECSYNAIYNNITYTILEGIryaVQNV-KCP 988

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599  684 gdsRTRIGFMTFDSTIHFYNLQEGLSQP-------------QMLIVSDIDDVFLPTP-DSLLVNLYESKELIKDLLNALP 749
Cdd:PTZ00395   989 ---QTKIAIITFNSSIYFYHCKGGKGVSgeegdggggsgnhQVIVMSDVDDPFLPLPlEDLFFGCVEEIDKINTLIDTIK 1065

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599  750 NMFTNTRETHSALGPALQAAFKLMSPTGG--RVSVFQTQLPSLGAGLLQSREDPNQRSSTKVVQHLgpatdFYKKLALDC 827
Cdd:PTZ00395  1066 SVSTTMQSYGSCGNSALKIAMDMLKERNGlgSICMFYTTTPNCGIGAIKELKKDLQENFLEVKQKI-----FYDSLLLDL 1140

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599  828 SGQQTAVDLFLLSSQYSDLA--SLACMSKYSAGCIYYYPSFHYthnpsqaeklQKDLKR-YL-------TRKIGFEAVMR 897
Cdd:PTZ00395  1141 YAFNISVDIFIISSNNVRVCvpSLQYVAQNTGGKILFVENFLW----------QKDYKEiYMnimdtltSEDIAYCCELK 1210

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599  898 IRCTKGLSMHTF---HGNF-FVRSTDLLSLANINPDAGFAVQLSIEESLTDTSLVCFQTALLYTSSKGERRIRVHTLCLP 973
Cdd:PTZ00395  1211 LRYSHHMSVKKLfccNNNFnSIISVDTIKIPKIRHDQTFAFLLNYSDISESKKQIYFQCACIYTNLWGDRFVRLHTTHMN 1290

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599  974 VVSSLADVYAGVDVQAaiclLANMAVDRSVSSSLSDarDALVNAVVDSLSA----YGSTVSNLQHSA-LMAPSSLKLFPL 1048
Cdd:PTZ00395  1291 LTSSLSTVFRYTDAEA----LMNILIKQLCTNILHN--DNYSKIIIDNLAAilfsYRINCASSAHSGqLILPDTLKLLPL 1364

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599 1049 YVLALLKQKAfrTGTSTRLDDRVYAMCQIKSQPLVHLMKMIHPNLY--RIDRLTDE-GAVHVNDRIVpQPPLQKLSAEKL 1125
Cdd:PTZ00395  1365 FTSSLLKHNV--TKKEILHDLKVYSLIKLLSMPIISSLLYVYPVMYviHIKGKTNEiDSMDVDDDLF-IPKTIPSSAEKI 1441

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599 1126 TREGAFLMDCGSVFYIWVGKGCDNNFIEDVLGytnfaSIP-QKMTHLPEL-DTLSSERARSFItwlrdsRPLSPILH--- 1200
Cdd:PTZ00395  1442 YSNGIYLLDACTHFYLYFGFHSDANFAKEIVG-----DIPtEKNAHELNLtDTPNAQKVQRII------KNLSRIHHfnk 1510

                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....*
gi 2217348599 1201 -----IVKDESPAKAEFFQHLIEDRTEAAFSYYEFLLHVQQQICK 1240
Cdd:PTZ00395  1511 yvplvMVAPKSNEEEHLISLCVEDKADKEYSYVNFLCFIHKLVHK 1555
GEL smart00262
Gelsolin homology domain; Gelsolin/severin/villin homology domain. Calcium-binding and ...
 1105-1147 9.57e-03

Gelsolin homology domain; Gelsolin/severin/villin homology domain. Calcium-binding and actin-binding. Both intra- and extracellular domains.


Pssm-ID: 214590 [Multi-domain]  Cd Length: 90  Bit Score: 36.50  E-value: 9.57e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2217348599  1105 VHVNDRIVPQPPLQKLSAEKLTREGAFLMDCGSVFYIWVGKGC 1147
Cdd:smart00262    3 VRVKGKRNVRVPEVPFSQGSLNSGDCYILDTGSEIYVWVGKKS 45
 
Name Accession Description Interval E-value
COG5028 COG5028
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking ...
 526-1231 0e+00

Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion];


Pssm-ID: 227361 [Multi-domain]  Cd Length: 861  Bit Score: 564.80  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599  526 NCSPDSFRCTLTNIPQTQALLNKAKLPLGLLLHPFRDLT----QLPVITSNTIVRCRSCRTYINPFVSFIDQ-RRWKCNL 600
Cdd:COG5028    147 NCSPKYVRSTMYAIPETNDLLKKSKIPFGLVIRPFLELYpeedPVPLVEDGSIVRCRRCRSYINPFVQFIEQgRKWRCNI 226

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599  601 CYRVNDVPEEFmYNPLTRS--YGEPHKRPEVQNSTVEFIASSDYMLRPPQPAVYLFVLDVSHNAVEAGYLTILCQSLLEN 678
Cdd:COG5028    227 CRSKNDVPEGF-DNPSGPNdpRSDRYSRPELKSGVVDFLAPKEYSLRQPPPPVYVFLIDVSFEAIKNGLVKAAIRAILEN 305

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599  679 LDKLPG-DSRTRIGFMTFDSTIHFYNLQEGLSQpQMLIVSDIDDVFLPTP-DSLLVNLYESKELIKDLLNALPNMFTNTR 756
Cdd:COG5028    306 LDQIPNfDPRTKIAIICFDSSLHFFKLSPDLDE-QMLIVSDLDEPFLPFPsGLFVLPLKSCKQIIETLLDRVPRIFQDNK 384

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599  757 ETHSALGPALQAAFKLMSPTGGRVSVFQTQLPSLGAGLLQSREDPNQRsstkvvqHLGPATDFYKKLALDCSGQQTAVDL 836
Cdd:COG5028    385 SPKNALGPALKAAKSLIGGTGGKIIVFLSTLPNMGIGKLQLREDKESS-------LLSCKDSFYKEFAIECSKVGISVDL 457

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599  837 FLLSSQYSDLASLACMSKYSAGCIYYYPSFHYThNPSQAEKLQKDLKRYLTRKIGFEAVMRIRCTKGLSMHTFHGNFFVR 916
Cdd:COG5028    458 FLTSEDYIDVATLSHLCRYTGGQTYFYPNFSAT-RPNDATKLANDLVSHLSMEIGYEAVMRVRCSTGLRVSSFYGNFFNR 536

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599  917 STDLLSLANINPDAGFAVQLSIEESLTdTSLVCFQTALLYTSSKGERRIRVHTLCLPVVSSLADVYAGVDVQAAICLLAN 996
Cdd:COG5028    537 SSDLCAFSTMPRDTSLLVEFSIDEKLM-TSDVYFQVALLYTLNDGERRIRVVNLSLPTSSSIREVYASADQLAIACILAK 615

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599  997 MAVDRSVSSSLSDARDALVNAVVDSLSAY-GSTVSNLQHSALMAPSSLKLFPLYVLALLKQKAFRTGtSTRLDDRVYAMC 1075
Cdd:COG5028    616 KASTKALNSSLKEARVLINKSMVDILKAYkKELVKSNTSTQLPLPANLKLLPLLMLALLKSSAFRSG-STPSDIRISALN 694

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599 1076 QIKSQPLVHLMKMIHPNLYRIDRLTDEGAVHVNDRIVPQPPLqKLSAEKLTREGAFLMDCGSVFYIWVGKGCDNNFIEDV 1155
Cdd:COG5028    695 RLTSLPLKQLMRNIYPTLYALHDMPIEAGLPDEGLLVLPSPI-NATSSLLESGGLYLIDTGQKIFLWFGKDAVPSLLQDL 773

                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217348599 1156 LGYTNFASIPQKMTHLPELDTLSSERARSFITWLRDSRP-LSPILHIVKD--ESPAKAEFFQHLIEDRTEAAFSYYEFL 1231
Cdd:COG5028    774 FGVDSLSDIPSGKFTLPPTGNEFNERVRNIIGELRSVNDdSTLPLVLVRGggDPSLRLWFFSTLVEDKTLNIPSYLDYL 852
Sec24-like cd01479
Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the ...
 647-890 1.02e-131

Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes of vesicular carriers within the endocytic and the biosynthetic pathways are COP- and clathrin-coated vesicles. Formation of COPII vesicles requires the ordered assembly of the coat built from several cytosolic components GTPase Sar1, complexes of Sec23-Sec24 and Sec13-Sec31. The process is initiated by the conversion of GDP to GTP by the GTPase Sar1 which then recruits the heterodimeric complex of Sec23 and Sec24. This heterodimeric complex generates the pre-budding complex. The final step leading to membrane deformation and budding of COPII-coated vesicles is carried by the heterodimeric complex Sec13-Sec31. The members of this CD belong to the Sec23-like family. Sec 24 is very similar to Sec23. The Sec23 and Sec24 polypeptides fold into five distinct domains: a beta-barrel, a zinc finger, a vWA or trunk, an all helical region and a carboxy Gelsolin domain. The members of this subgroup carry a partial MIDAS motif and have the overall Para-Rossmann type fold that is characteristic of this superfamily.


Pssm-ID: 238756 [Multi-domain]  Cd Length: 244  Bit Score: 402.81  E-value: 1.02e-131
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599  647 PQPAVYLFVLDVSHNAVEAGYLTILCQSLLENLDKLPGD-SRTRIGFMTFDSTIHFYNLQEGLSQPQMLIVSDIDDVFLP 725
Cdd:cd01479      1 PQPAVYVFLIDVSYNAIKSGLLATACEALLSNLDNLPGDdPRTRVGFITFDSTLHFFNLKSSLEQPQMMVVSDLDDPFLP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599  726 TPDSLLVNLYESKELIKDLLNALPNMFTNTRETHSALGPALQAAFKLMSPTGGRVSVFQTQLPSLGAGLLQSREDPNQRS 805
Cdd:cd01479     81 LPDGLLVNLKESRQVIEDLLDQIPEMFQDTKETESALGPALQAAFLLLKETGGKIIVFQSSLPTLGAGKLKSREDPKLLS 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599  806 STKVVQHLGPATDFYKKLALDCSGQQTAVDLFLLSSQYSDLASLACMSKYSAGCIYYYPSFHyTHNPSQAEKLQKDLKRY 885
Cdd:cd01479    161 TDKEKQLLQPQTDFYKKLALECVKSQISVDLFLFSNQYVDVATLGCLSRLTGGQVYYYPSFN-FSAPNDVEKLVNELARY 239


                   ....*
gi 2217348599  886 LTRKI 890
Cdd:cd01479    240 LTRKI 244
Sec23_trunk pfam04811
Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum ...
 647-886 1.04e-107

Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is known as the trunk domain and has an alpha/beta vWA fold and forms the dimer interface.


Pssm-ID: 398467 [Multi-domain]  Cd Length: 241  Bit Score: 338.46  E-value: 1.04e-107
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599  647 PQPAVYLFVLDVSHNAVEAGYLTILCQSLLENLDKLPGDSRTRIGFMTFDSTIHFYNLQEGLSQPQMLIVSDIDDVFLPT 726
Cdd:pfam04811    1 PQPPVFLFVIDVSYNAIKSGLLAALKESLLQSLDLLPGDPRARVGFITFDSTVHFFNLGSSLRQPQMLVVSDLQDMFLPL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599  727 PDSLLVNLYESKELIKDLLNALPNMFTNTRETHSALGPALQAAFKLM--SPTGGRVSVFQTQLPSLGA-GLLQSREDPNQ 803
Cdd:pfam04811   81 PDRFLVPLSECRFVLEDLLEQLPPMFPVTKRPERCLGPALQAAFLLLkaAFTGGKIMVFQGGLPTVGPgGKLKSRLDESH 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599  804 RSSTKVVQHLGPATD-FYKKLALDCSGQQTAVDLFLLSSQYSDLASLACMSKYSAGCIYYYPSFHYTHnpsQAEKLQKDL 882
Cdd:pfam04811  161 HGTDKEKAKLVKKADkFYKSLAKECVKQGHSVDLFAFSLDYVDVATLGQLSRLTGGQVYLYPSFQADV---DGSKFKQDL 237


                   ....
gi 2217348599  883 KRYL 886
Cdd:pfam04811  238 QRYF 241
trunk_domain cd01468
trunk domain. COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi ...
 647-884 4.55e-105

trunk domain. COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is known as the trunk domain and has an alpha/beta vWA fold and forms the dimer interface. Some members of this family possess a partial MIDAS motif that is a characteristic feature of most vWA domain proteins.


Pssm-ID: 238745 [Multi-domain]  Cd Length: 239  Bit Score: 331.13  E-value: 4.55e-105
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599  647 PQPAVYLFVLDVSHNAVEAGYLTILCQSLLENLDKLPGDSRTRIGFMTFDSTIHFYNLQEGLSQPQMLIVSDIDDVFLPT 726
Cdd:cd01468      1 PQPPVFVFVIDVSYEAIKEGLLQALKESLLASLDLLPGDPRARVGLITYDSTVHFYNLSSDLAQPKMYVVSDLKDVFLPL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599  727 PDSLLVNLYESKELIKDLLNALPNMFTN--TRETHSALGPALQAAFKLMSPT--GGRVSVFQTQLPSLGAGLLQSREDPN 802
Cdd:cd01468     81 PDRFLVPLSECKKVIHDLLEQLPPMFWPvpTHRPERCLGPALQAAFLLLKGTfaGGRIIVFQGGLPTVGPGKLKSREDKE 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599  803 QRSSTKVVQHLGPATDFYKKLALDCSGQQTAVDLFLLSSQYSDLASLACMSKYSAGCIYYYPSFHYthnPSQAEKLQKDL 882
Cdd:cd01468    161 PIRSHDEAQLLKPATKFYKSLAKECVKSGICVDLFAFSLDYVDVATLKQLAKSTGGQVYLYDSFQA---PNDGSKFKQDL 237


                   ..
gi 2217348599  883 KR 884
Cdd:cd01468    238 QR 239
PTZ00395 PTZ00395
Sec24-related protein; Provisional
 612-1240 3.50e-44

Sec24-related protein; Provisional


Pssm-ID: 185594 [Multi-domain]  Cd Length: 1560  Bit Score: 175.65  E-value: 3.50e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599  612 MYNPLTRSYGEPHKRPEVQNStvefiassdYMLRPPQ-----PAVYLFVLDVSHNAVEAGYLTILCQSL---LENLdKLP 683
Cdd:PTZ00395   919 MKNLICEKNGEPDSAKIRRNS---------FLAKYPQvknmlPPYFVFVVECSYNAIYNNITYTILEGIryaVQNV-KCP 988

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599  684 gdsRTRIGFMTFDSTIHFYNLQEGLSQP-------------QMLIVSDIDDVFLPTP-DSLLVNLYESKELIKDLLNALP 749
Cdd:PTZ00395   989 ---QTKIAIITFNSSIYFYHCKGGKGVSgeegdggggsgnhQVIVMSDVDDPFLPLPlEDLFFGCVEEIDKINTLIDTIK 1065

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599  750 NMFTNTRETHSALGPALQAAFKLMSPTGG--RVSVFQTQLPSLGAGLLQSREDPNQRSSTKVVQHLgpatdFYKKLALDC 827
Cdd:PTZ00395  1066 SVSTTMQSYGSCGNSALKIAMDMLKERNGlgSICMFYTTTPNCGIGAIKELKKDLQENFLEVKQKI-----FYDSLLLDL 1140

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599  828 SGQQTAVDLFLLSSQYSDLA--SLACMSKYSAGCIYYYPSFHYthnpsqaeklQKDLKR-YL-------TRKIGFEAVMR 897
Cdd:PTZ00395  1141 YAFNISVDIFIISSNNVRVCvpSLQYVAQNTGGKILFVENFLW----------QKDYKEiYMnimdtltSEDIAYCCELK 1210

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599  898 IRCTKGLSMHTF---HGNF-FVRSTDLLSLANINPDAGFAVQLSIEESLTDTSLVCFQTALLYTSSKGERRIRVHTLCLP 973
Cdd:PTZ00395  1211 LRYSHHMSVKKLfccNNNFnSIISVDTIKIPKIRHDQTFAFLLNYSDISESKKQIYFQCACIYTNLWGDRFVRLHTTHMN 1290

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599  974 VVSSLADVYAGVDVQAaiclLANMAVDRSVSSSLSDarDALVNAVVDSLSA----YGSTVSNLQHSA-LMAPSSLKLFPL 1048
Cdd:PTZ00395  1291 LTSSLSTVFRYTDAEA----LMNILIKQLCTNILHN--DNYSKIIIDNLAAilfsYRINCASSAHSGqLILPDTLKLLPL 1364

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599 1049 YVLALLKQKAfrTGTSTRLDDRVYAMCQIKSQPLVHLMKMIHPNLY--RIDRLTDE-GAVHVNDRIVpQPPLQKLSAEKL 1125
Cdd:PTZ00395  1365 FTSSLLKHNV--TKKEILHDLKVYSLIKLLSMPIISSLLYVYPVMYviHIKGKTNEiDSMDVDDDLF-IPKTIPSSAEKI 1441

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599 1126 TREGAFLMDCGSVFYIWVGKGCDNNFIEDVLGytnfaSIP-QKMTHLPEL-DTLSSERARSFItwlrdsRPLSPILH--- 1200
Cdd:PTZ00395  1442 YSNGIYLLDACTHFYLYFGFHSDANFAKEIVG-----DIPtEKNAHELNLtDTPNAQKVQRII------KNLSRIHHfnk 1510

                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....*
gi 2217348599 1201 -----IVKDESPAKAEFFQHLIEDRTEAAFSYYEFLLHVQQQICK 1240
Cdd:PTZ00395  1511 yvplvMVAPKSNEEEHLISLCVEDKADKEYSYVNFLCFIHKLVHK 1555
Sec23_helical pfam04815
Sec23/Sec24 helical domain; COPII-coated vesicles carry proteins from the endoplasmic ...
 986-1087 2.10e-34

Sec23/Sec24 helical domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is composed of five alpha helices.


Pssm-ID: 461441 [Multi-domain]  Cd Length: 103  Bit Score: 127.23  E-value: 2.10e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599  986 DVQAAICLLANMAVDRSVSSSLSDARDALVNAVVDSLSAYGSTVSNLQHSA-LMAPSSLKLFPLYVLALLKQKAFRTGTS 1064
Cdd:pfam04815    1 DQEAIAVLLAKKAVEKALSSSLSDAREALDNKLVDILAAYRKYCASSSSPGqLILPESLKLLPLYMLALLKSPALRGGNS 80

                           90       100
                   ....*....|....*....|...
gi 2217348599 1065 TRLDDRVYAMCQIKSQPLVHLMK 1087
Cdd:pfam04815   81 SPSDERAYARHLLLSLPVEELLL 103
Sec23_BS pfam08033
Sec23/Sec24 beta-sandwich domain;
891-975 3.04e-32

Sec23/Sec24 beta-sandwich domain;


Pssm-ID: 429794 [Multi-domain]  Cd Length: 86  Bit Score: 120.33  E-value: 3.04e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599  891 GFEAVMRIRCTKGLSMHTFHGNFFVRS-TDLLSLANINPDAGFAVQLSIEESLTDTSLVCFQTALLYTSSKGERRIRVHT 969
Cdd:pfam08033    1 GFNAVLRVRTSKGLKVSGFIGNFVSRSsGDTWKLPSLDPDTSYAFEFDIDEPLPNGSNAYIQFALLYTHSSGERRIRVTT 80


                   ....*.
gi 2217348599  970 LCLPVV 975
Cdd:pfam08033   81 VALPVT 86
SEC23 COG5047
Vesicle coat complex COPII, subunit SEC23 [Intracellular trafficking and secretion];
530-1146 3.45e-22

Vesicle coat complex COPII, subunit SEC23 [Intracellular trafficking and secretion];


Pssm-ID: 227380 [Multi-domain]  Cd Length: 755  Bit Score: 103.42  E-value: 3.45e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599  530 DSFRCTLTNIPQTQALLNKAKLPLGLLLHPFRDLTQLPVITSNTIVRCRSCRTYINPFVSfIDQRR--WKCNLCYRVNDV 607
Cdd:COG5047     10 DGIRLTWNVFPATRGDATRTVIPIACLYTPLHEDDALTVNYYEPVKCTAPCKAVLNPYCH-IDERNqsWICPFCNQRNTL 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599  608 PEEfmYNPLTRSYGEPhkRPEVQNSTVEFIASsdymlRPPQ-PAVYLFVLDVshnAVEAGYLTILCQSLLENLDKLPGDS 686
Cdd:COG5047     89 PPQ--YRDISNANLPL--ELLPQSSTIEYTLS-----KPVIlPPVFFFVVDA---CCDEEELTALKDSLIVSLSLLPPEA 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599  687 rtRIGFMTFDSTIHF----------------------YNLQE--GLSQPQMLIV--SDIDDVFLPTPDSLLVNLYESKEL 740
Cdd:COG5047    157 --LVGLITYGTSIQVhelnaenhrrsyvfsgnkeytkENLQEllALSKPTKSGGfeSKISGIGQFASSRFLLPTQQCEFK 234

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599  741 IKDLLNAL-------PNMFTNTRETHSALGPA---LQAAFKLMsptGGRVSVFQTQLPSLGAGLLQSRE--DP---NQRS 805
Cdd:COG5047    235 LLNILEQLqpdpwpvPAGKRPLRCTGSALNIAsslLEQCFPNA---GCHIVLFAGGPCTVGPGTVVSTElkEPmrsHHDI 311

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599  806 STKVVQHLGPATDFYKKLALDCSGQQTAVDLFLLSSQYSDLASLACMSKYSAGCIYYYPSFhythnpsQAEKLQKDLKRY 885
Cdd:COG5047    312 ESDSAQHSKKATKFYKGLAERVANQGHALDIFAGCLDQIGIMEMEPLTTSTGGALVLSDSF-------TTSIFKQSFQRI 384

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599  886 LTR------KIGFEAVMRIRCTKGLSMHTFHGN---------------FFVRSTDLLSLANINPDAGFAVQLSIEESLTD 944
Cdd:COG5047    385 FNRdsegylKMGFNANMEVKTSKNLKIKGLIGHavsvkkkannisdseIGIGATNSWKMASLSPKSNYALYFEIALGAAS 464

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599  945 TS-------LVCFQTalLYTSSKGERRIRVHTLCLPVVSSLADV-YAGVDVQAAICLLANMAVDRSVSSSLSDArDALVN 1016
Cdd:COG5047    465 GSaqrpaeaYIQFIT--TYQHSSGTYRIRVTTVARMFTDGGLPKiNRSFDQEAAAVFMARIAAFKAETEDIIDV-FRWID 541

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599 1017 AVVDSLSAYGSTVSNLQHSALMAPSSLKLFPLYVLALLKQKAFRTGtSTRLDDRVYAMCQIKSQPLVHLMKMIHPNLYRI 1096
Cdd:COG5047    542 RNLIRLCQKFADYRKDDPSSFRLDPNFTLYPQFMYHLRRSPFLSVF-NNSPDETAFYRHMLNNADVNDSLIMIQPTLQSY 620

                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|
gi 2217348599 1097 DRLTDEGAVHVnDRIVPQPPLQKLSAEKLTregaFLMDCGSVFYIWVGKG 1146
Cdd:COG5047    621 SFEKGGVPVLL-DSVSVKPDVILLLDTFFH----ILIFHGSYIAQWRNAG 665
zf-Sec23_Sec24 pfam04810
Sec23/Sec24 zinc finger; COPII-coated vesicles carry proteins from the endoplasmic reticulum ...
 574-610 7.98e-16

Sec23/Sec24 zinc finger; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is found to be zinc binding domain.


Pssm-ID: 461437 [Multi-domain]  Cd Length: 38  Bit Score: 72.09  E-value: 7.98e-16
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2217348599  574 IVRCRSCRTYINPFVSFIDQ-RRWKCNLCYRVNDVPEE 610
Cdd:pfam04810    1 PVRCRRCRAYLNPFCQFDFGgKKWTCNFCGTRNPVPPE 38
PLN00162 PLN00162
transport protein sec23; Provisional
 530-1014 6.85e-14

transport protein sec23; Provisional


Pssm-ID: 215083 [Multi-domain]  Cd Length: 761  Bit Score: 76.52  E-value: 6.85e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599  530 DSFRCTLTNIPQTQALLNKAKLPLGLLLHPFRDLTQLPVITSNTIvRCRSCRTYINPF--VSFiDQRRWKCNLCYRVNDV 607
Cdd:PLN00162    10 DGVRMSWNVWPSSKIEASKCVIPLAALYTPLKPLPELPVLPYDPL-RCRTCRAVLNPYcrVDF-QAKIWICPFCFQRNHF 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599  608 PeefmynpltRSY---GEPHKRPEV--QNSTVEFiASSDYMLRPPQPAVYLFVLDVSHNAVEAGYLTilcQSLLENLDKL 682
Cdd:PLN00162    88 P---------PHYssiSETNLPAELfpQYTTVEY-TLPPGSGGAPSPPVFVFVVDTCMIEEELGALK---SALLQAIALL 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599  683 PGDSrtRIGFMTFDSTIHFYNL------------------------QEGLS----QPQMLIVSDIDDVFLPTP-DSLLVN 733
Cdd:PLN00162   155 PENA--LVGLITFGTHVHVHELgfsecsksyvfrgnkevskdqileQLGLGgkkrRPAGGGIAGARDGLSSSGvNRFLLP 232

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599  734 LYESKELIKDLLNALPNMFTNTRETHSAL---GPALQAAFKLM---SP-TGGRVSVFqTQLPS-LGAGLLQSREDPNQRS 805
Cdd:PLN00162   233 ASECEFTLNSALEELQKDPWPVPPGHRPArctGAALSVAAGLLgacVPgTGARIMAF-VGGPCtEGPGAIVSKDLSEPIR 311

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599  806 STK-----VVQHLGPATDFYKKLALDCSGQQTAVDLFLLSSQYSDLASLACMSKYSAGCIYYYPSFHythnpsqAEKLQK 880
Cdd:PLN00162   312 SHKdldkdAAPYYKKAVKFYEGLAKQLVAQGHVLDVFACSLDQVGVAEMKVAVERTGGLVVLAESFG-------HSVFKD 384

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599  881 DLKRYLTR------KIGFEAVMRIRCTKGL----------SMH----------TFHGNffvrsTDLLSLANINPDAGFAV 934
Cdd:PLN00162   385 SLRRVFERdgegslGLSFNGTFEVNCSKDVkvqgaigpcaSLEkkgpsvsdteIGEGG-----TTAWKLCGLDKKTSLAV 459

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217348599  935 --QLSIEESLTDTSL---VCFQTALLYTSSKGERRIRVHTLCLPVV--SSLADVYAGVDVQAAICLLANMAVDRSVSssl 1007
Cdd:PLN00162   460 ffEVANSGQSNPQPPgqqFFLQFLTRYQHSNGQTRLRVTTVTRRWVegSSSEELVAGFDQEAAAVVMARLASHKMET--- 536


                   ....*..
gi 2217348599 1008 SDARDAL 1014
Cdd:PLN00162   537 EEEFDAT 543
Gelsolin pfam00626
Gelsolin repeat;
1112-1186 3.12e-11

Gelsolin repeat;


Pssm-ID: 395501 [Multi-domain]  Cd Length: 76  Bit Score: 60.40  E-value: 3.12e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217348599 1112 VPQPPLQKLSAEKLTREGAFLMDCGSVFYIWVGKGcdNNFIEDVLGYTNFASIP-QKMTHLPELDTLS-SERARSFI 1186
Cdd:pfam00626    2 FVLPPPVPLSQESLNSGDCYLLDNGFTIFLWVGKG--SSLLEKLFAALLAAQLDdDERFPLPEVIRVPqGKEPARFL 76
GEL smart00262
Gelsolin homology domain; Gelsolin/severin/villin homology domain. Calcium-binding and ...
 1105-1147 9.57e-03

Gelsolin homology domain; Gelsolin/severin/villin homology domain. Calcium-binding and actin-binding. Both intra- and extracellular domains.


Pssm-ID: 214590 [Multi-domain]  Cd Length: 90  Bit Score: 36.50  E-value: 9.57e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2217348599  1105 VHVNDRIVPQPPLQKLSAEKLTREGAFLMDCGSVFYIWVGKGC 1147
Cdd:smart00262    3 VRVKGKRNVRVPEVPFSQGSLNSGDCYILDTGSEIYVWVGKKS 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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