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Conserved domains on  [gi|2452621404|ref|XP_053911491|]
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hyaluronan and proteoglycan link protein 1 [Cuculus canorus]

Protein Classification

immunoglobulin domain-containing family protein; immunoglobulin domain-containing protein( domain architecture ID 10147181)

immunoglobulin (Ig) domain-containing family protein is a member of a large superfamily containing cell surface antigen receptors, co-receptors and co-stimulatory molecules of the immune system, molecules involved in antigen presentation to lymphocytes, cell adhesion molecules, certain cytokine receptors and intracellular muscle proteins; immunoglobulin domains are typically divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets| immunoglobulin (Ig) domain-containing protein adopts a fold comprised of a sandwich of two beta sheets and may function in cell adhesion and/or pattern recognition

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Link_domain_HAPLN_module_1 cd03518
Link_domain_HAPLN_module_1; this link domain is found in the first link module of proteins ...
 161-255 1.95e-69

Link_domain_HAPLN_module_1; this link domain is found in the first link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two contiguous link modules. Both link modules of cartilage link protein are involved in interaction with HA. In cartilage, a chondroitin sulfate proteoglycan core protein (CSPG) aggrecan forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Aggregates with other CSPGs substituting for aggregan may contribute to the structural integrity of many different tissues. Members of the vertebrate HAPLN gene family are physically linked adjacent to CSPG genes.


:

Pssm-ID: 239595  Cd Length: 95  Bit Score: 212.29  E-value: 1.95e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2452621404 161 VVFPYSPRLGRYNLNFHEAQRACLDQDSVIASFDQLYDAWRSGLDWCNAGWLSDGSVQYPITKPREPCGGKNTVPGVRNY 240
Cdd:cd03518     1 VVFPYQPRLGRYNLNFHEAQQACEEQDATLASFEQLYQAWTEGLDWCNAGWLSDGTVQYPITKPREPCGGKRTVPGLRSY 80

                          90
                  ....*....|....*
gi 2452621404 241 GFWDKDKSQYDVFCF 255
Cdd:cd03518    81 GERDKMLSRYDAFCF 95
Ig_LP_like cd05877
Immunoglobulin (Ig)-like domain of human cartilage link protein (LP), and similar domains; The ...
 45-163 2.43e-69

Immunoglobulin (Ig)-like domain of human cartilage link protein (LP), and similar domains; The members here are composed of the immunoglobulin (Ig)-like domain similar to that found in human cartilage link protein (LP; also called hyaluronan and proteoglycan link protein). In cartilage, chondroitin-keratan sulfate proteoglycan (CSPG), aggrecan, forms cartilage link protein stabilized aggregates with hyaluronan (HA). These aggregates contribute to the tissue's load bearing properties. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


:

Pssm-ID: 409461  Cd Length: 117  Bit Score: 212.57  E-value: 2.43e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2452621404  45 AEQAKIFSHRGGNVTLPCKFYHEHTStagSGTHKIRVKWTKLTSDYLKEVDVFVAMGHHRKSYGNYQGRVFLRESSENDA 124
Cdd:cd05877     2 TVQAKVFSHRGGNVTLPCRYHYEPEL---SAPRKIRVKWTKLEVDYAKEEDVLVAIGTRHKSYGSYQGRVFLRRADDLDA 78

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2452621404 125 SLIITNLILEDYGRYKCEIIEGLEDDTAVVALNLEGVVF 163
Cdd:cd05877    79 SLVITDLRLEDYGRYRCEVIDGLEDESVVVALRLRGVVF 117
Link_domain_HAPLN_module_2 cd03519
Link_domain_HAPLN_module_2; this link domain is found in the second link module of proteins ...
 262-352 1.57e-56

Link_domain_HAPLN_module_2; this link domain is found in the second link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two contiguous link modules. Both link modules of cartilage link protein are involved in interaction with HA. In cartilage, a chondroitin sulfate proteoglycan core protein (CSPG) aggrecan forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Aggregates with other CSPGs substituting for aggregan may contribute to the structural integrity of many different tissues. Members of the vertebrate HAPLN gene family are physically linked adjacent to CSPG genes.


:

Pssm-ID: 239596  Cd Length: 91  Bit Score: 179.16  E-value: 1.57e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2452621404 262 RFYYLIHPTKLTYDEAIQACVKDGAQIAKVGQIFAAWKLLGYDRCDAGWLADGSVRYPISRPRKRCSPNEAAVRFVGFPD 341
Cdd:cd03519     1 GVFYLLHPGKLTFSEAVAACQRDGAQIAKVGQLFAAWKFHGLDRCDAGWLADGSVRYPISRPRPRCGPLEPGVRSFGFPD 80

                          90
                  ....*....|.
gi 2452621404 342 KKHKLYGVYCF 352
Cdd:cd03519    81 KKHKLYGVYCY 91
 
Name Accession Description Interval E-value
Link_domain_HAPLN_module_1 cd03518
Link_domain_HAPLN_module_1; this link domain is found in the first link module of proteins ...
 161-255 1.95e-69

Link_domain_HAPLN_module_1; this link domain is found in the first link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two contiguous link modules. Both link modules of cartilage link protein are involved in interaction with HA. In cartilage, a chondroitin sulfate proteoglycan core protein (CSPG) aggrecan forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Aggregates with other CSPGs substituting for aggregan may contribute to the structural integrity of many different tissues. Members of the vertebrate HAPLN gene family are physically linked adjacent to CSPG genes.


Pssm-ID: 239595  Cd Length: 95  Bit Score: 212.29  E-value: 1.95e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2452621404 161 VVFPYSPRLGRYNLNFHEAQRACLDQDSVIASFDQLYDAWRSGLDWCNAGWLSDGSVQYPITKPREPCGGKNTVPGVRNY 240
Cdd:cd03518     1 VVFPYQPRLGRYNLNFHEAQQACEEQDATLASFEQLYQAWTEGLDWCNAGWLSDGTVQYPITKPREPCGGKRTVPGLRSY 80

                          90
                  ....*....|....*
gi 2452621404 241 GFWDKDKSQYDVFCF 255
Cdd:cd03518    81 GERDKMLSRYDAFCF 95
Ig_LP_like cd05877
Immunoglobulin (Ig)-like domain of human cartilage link protein (LP), and similar domains; The ...
 45-163 2.43e-69

Immunoglobulin (Ig)-like domain of human cartilage link protein (LP), and similar domains; The members here are composed of the immunoglobulin (Ig)-like domain similar to that found in human cartilage link protein (LP; also called hyaluronan and proteoglycan link protein). In cartilage, chondroitin-keratan sulfate proteoglycan (CSPG), aggrecan, forms cartilage link protein stabilized aggregates with hyaluronan (HA). These aggregates contribute to the tissue's load bearing properties. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 409461  Cd Length: 117  Bit Score: 212.57  E-value: 2.43e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2452621404  45 AEQAKIFSHRGGNVTLPCKFYHEHTStagSGTHKIRVKWTKLTSDYLKEVDVFVAMGHHRKSYGNYQGRVFLRESSENDA 124
Cdd:cd05877     2 TVQAKVFSHRGGNVTLPCRYHYEPEL---SAPRKIRVKWTKLEVDYAKEEDVLVAIGTRHKSYGSYQGRVFLRRADDLDA 78

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2452621404 125 SLIITNLILEDYGRYKCEIIEGLEDDTAVVALNLEGVVF 163
Cdd:cd05877    79 SLVITDLRLEDYGRYRCEVIDGLEDESVVVALRLRGVVF 117
Link_domain_HAPLN_module_2 cd03519
Link_domain_HAPLN_module_2; this link domain is found in the second link module of proteins ...
 262-352 1.57e-56

Link_domain_HAPLN_module_2; this link domain is found in the second link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two contiguous link modules. Both link modules of cartilage link protein are involved in interaction with HA. In cartilage, a chondroitin sulfate proteoglycan core protein (CSPG) aggrecan forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Aggregates with other CSPGs substituting for aggregan may contribute to the structural integrity of many different tissues. Members of the vertebrate HAPLN gene family are physically linked adjacent to CSPG genes.


Pssm-ID: 239596  Cd Length: 91  Bit Score: 179.16  E-value: 1.57e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2452621404 262 RFYYLIHPTKLTYDEAIQACVKDGAQIAKVGQIFAAWKLLGYDRCDAGWLADGSVRYPISRPRKRCSPNEAAVRFVGFPD 341
Cdd:cd03519     1 GVFYLLHPGKLTFSEAVAACQRDGAQIAKVGQLFAAWKFHGLDRCDAGWLADGSVRYPISRPRPRCGPLEPGVRSFGFPD 80

                          90
                  ....*....|.
gi 2452621404 342 KKHKLYGVYCF 352
Cdd:cd03519    81 KKHKLYGVYCY 91
Xlink pfam00193
Extracellular link domain;
161-255 2.46e-46

Extracellular link domain;


Pssm-ID: 459706  Cd Length: 92  Bit Score: 152.73  E-value: 2.46e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2452621404 161 VVFPYSPRlGRYNLNFHEAQRACLDQDSVIASFDQLYDAWRSGLDWCNAGWLSDGSVQYPITKPREPCGGknTVPGVRNY 240
Cdd:pfam00193   1 GVFHLESP-GRYKLTFQEAQAACAALGATLATPEQLYAAWKAGLDTCDAGWLADGTVRYPITTPRPNCGG--NMPGVRQY 77

                          90
                  ....*....|....*
gi 2452621404 241 GFWDKDKSQYDVFCF 255
Cdd:pfam00193  78 GFRDPLSERYDAYCY 92
LINK smart00445
Link (Hyaluronan-binding);
159-256 1.22e-44

Link (Hyaluronan-binding);


Pssm-ID: 214667  Cd Length: 94  Bit Score: 148.64  E-value: 1.22e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2452621404  159 EGVVFPYSPRlGRYNLNFHEAQRACLDQDSVIASFDQLYDAWRSGLDWCNAGWLSDGSVQYPITKPREPCGGknTVPGVR 238
Cdd:smart00445   1 DGGVFHVEKN-GRYKLTFAEAREACRAQGATLATVGQLYAAWQDGFDTCDAGWLADGSVRYPIITPRPRCGG--NLPGVR 77

                           90
                   ....*....|....*...
gi 2452621404  239 NYGFWDKDkSQYDVFCFT 256
Cdd:smart00445  78 QYGFPDPT-SRYDAYCFN 94
LINK smart00445
Link (Hyaluronan-binding);
260-353 5.01e-39

Link (Hyaluronan-binding);


Pssm-ID: 214667  Cd Length: 94  Bit Score: 134.01  E-value: 5.01e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2452621404  260 NGRFYYLIH--PTKLTYDEAIQACVKDGAQIAKVGQIFAAWKLlGYDRCDAGWLADGSVRYPISRPRKRCSPNEAAVRFV 337
Cdd:smart00445   1 DGGVFHVEKngRYKLTFAEAREACRAQGATLATVGQLYAAWQD-GFDTCDAGWLADGSVRYPIITPRPRCGGNLPGVRQY 79

                           90
                   ....*....|....*.
gi 2452621404  338 GFPDKKHkLYGVYCFR 353
Cdd:smart00445  80 GFPDPTS-RYDAYCFN 94
Xlink pfam00193
Extracellular link domain;
261-352 2.53e-35

Extracellular link domain;


Pssm-ID: 459706  Cd Length: 92  Bit Score: 124.22  E-value: 2.53e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2452621404 261 GRFYYlIHPT--KLTYDEAIQACVKDGAQIAKVGQIFAAWKLlGYDRCDAGWLADGSVRYPISRPRKRCSPNEAAVRFVG 338
Cdd:pfam00193   1 GVFHL-ESPGryKLTFQEAQAACAALGATLATPEQLYAAWKA-GLDTCDAGWLADGTVRYPITTPRPNCGGNMPGVRQYG 78

                          90
                  ....*....|....
gi 2452621404 339 FPDKKHKLYGVYCF 352
Cdd:pfam00193  79 FRDPLSERYDAYCY 92
IGv smart00406
Immunoglobulin V-Type;
57-143 4.14e-09

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 52.77  E-value: 4.14e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2452621404   57 NVTLPCKFYhehtstaGSGTHKIRVKWTKLTSDylKEVDVFVAMGHHRKSYGN--YQGRV-FLRESSENDASLIITNLIL 133
Cdd:smart00406   1 SVTLSCKFS-------GSTFSSYYVSWVRQPPG--KGLEWLGYIGSNGSSYYQesYKGRFtISKDTSKNDVSLTISNLRV 71

                           90
                   ....*....|
gi 2452621404  134 EDYGRYKCEI 143
Cdd:smart00406  72 EDTGTYYCAV 81
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 38-144 1.04e-06

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 46.68  E-value: 1.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2452621404  38 GPRLLVVAEqakifshrGGNVTLPCKFyheHTSTAGSGThkiRVKWTKLTSDYLKEVDVFVAmghhRKSYGN--YQGRVF 115
Cdd:pfam07686   2 TPREVTVAL--------GGSVTLPCTY---SSSMSEAST---SVYWYRQPPGKGPTFLIAYY----SNGSEEgvKKGRFS 63

                          90       100       110
                  ....*....|....*....|....*....|
gi 2452621404 116 LRES-SENDASLIITNLILEDYGRYKCEII 144
Cdd:pfam07686  64 GRGDpSNGDGSLTIQNLTLSDSGTYTCAVI 93
 
Name Accession Description Interval E-value
Link_domain_HAPLN_module_1 cd03518
Link_domain_HAPLN_module_1; this link domain is found in the first link module of proteins ...
 161-255 1.95e-69

Link_domain_HAPLN_module_1; this link domain is found in the first link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two contiguous link modules. Both link modules of cartilage link protein are involved in interaction with HA. In cartilage, a chondroitin sulfate proteoglycan core protein (CSPG) aggrecan forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Aggregates with other CSPGs substituting for aggregan may contribute to the structural integrity of many different tissues. Members of the vertebrate HAPLN gene family are physically linked adjacent to CSPG genes.


Pssm-ID: 239595  Cd Length: 95  Bit Score: 212.29  E-value: 1.95e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2452621404 161 VVFPYSPRLGRYNLNFHEAQRACLDQDSVIASFDQLYDAWRSGLDWCNAGWLSDGSVQYPITKPREPCGGKNTVPGVRNY 240
Cdd:cd03518     1 VVFPYQPRLGRYNLNFHEAQQACEEQDATLASFEQLYQAWTEGLDWCNAGWLSDGTVQYPITKPREPCGGKRTVPGLRSY 80

                          90
                  ....*....|....*
gi 2452621404 241 GFWDKDKSQYDVFCF 255
Cdd:cd03518    81 GERDKMLSRYDAFCF 95
Ig_LP_like cd05877
Immunoglobulin (Ig)-like domain of human cartilage link protein (LP), and similar domains; The ...
 45-163 2.43e-69

Immunoglobulin (Ig)-like domain of human cartilage link protein (LP), and similar domains; The members here are composed of the immunoglobulin (Ig)-like domain similar to that found in human cartilage link protein (LP; also called hyaluronan and proteoglycan link protein). In cartilage, chondroitin-keratan sulfate proteoglycan (CSPG), aggrecan, forms cartilage link protein stabilized aggregates with hyaluronan (HA). These aggregates contribute to the tissue's load bearing properties. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 409461  Cd Length: 117  Bit Score: 212.57  E-value: 2.43e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2452621404  45 AEQAKIFSHRGGNVTLPCKFYHEHTStagSGTHKIRVKWTKLTSDYLKEVDVFVAMGHHRKSYGNYQGRVFLRESSENDA 124
Cdd:cd05877     2 TVQAKVFSHRGGNVTLPCRYHYEPEL---SAPRKIRVKWTKLEVDYAKEEDVLVAIGTRHKSYGSYQGRVFLRRADDLDA 78

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2452621404 125 SLIITNLILEDYGRYKCEIIEGLEDDTAVVALNLEGVVF 163
Cdd:cd05877    79 SLVITDLRLEDYGRYRCEVIDGLEDESVVVALRLRGVVF 117
Link_domain_HAPLN_module_2 cd03519
Link_domain_HAPLN_module_2; this link domain is found in the second link module of proteins ...
 262-352 1.57e-56

Link_domain_HAPLN_module_2; this link domain is found in the second link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two contiguous link modules. Both link modules of cartilage link protein are involved in interaction with HA. In cartilage, a chondroitin sulfate proteoglycan core protein (CSPG) aggrecan forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Aggregates with other CSPGs substituting for aggregan may contribute to the structural integrity of many different tissues. Members of the vertebrate HAPLN gene family are physically linked adjacent to CSPG genes.


Pssm-ID: 239596  Cd Length: 91  Bit Score: 179.16  E-value: 1.57e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2452621404 262 RFYYLIHPTKLTYDEAIQACVKDGAQIAKVGQIFAAWKLLGYDRCDAGWLADGSVRYPISRPRKRCSPNEAAVRFVGFPD 341
Cdd:cd03519     1 GVFYLLHPGKLTFSEAVAACQRDGAQIAKVGQLFAAWKFHGLDRCDAGWLADGSVRYPISRPRPRCGPLEPGVRSFGFPD 80

                          90
                  ....*....|.
gi 2452621404 342 KKHKLYGVYCF 352
Cdd:cd03519    81 KKHKLYGVYCY 91
Ig_CSPGs_LP_like cd05714
Immunoglobulin (Ig)-like domain of chondroitin sulfate proteoglycans (CSPGs), human cartilage ...
 44-163 3.24e-47

Immunoglobulin (Ig)-like domain of chondroitin sulfate proteoglycans (CSPGs), human cartilage link protein (LP), and similar domains; The members here are composed of the immunoglobulin (Ig)-like domain similar to that found in chondroitin sulfate proteoglycans (CSPGs) and human cartilage link protein (LP). Included in this group are the CSPGs aggrecan, versican, and neurocan. In CSPGs, this Ig-like domain is followed by hyaluronan (HA)-binding tandem repeats, and a C-terminal region with epidermal growth factor-like, lectin-like, and complement regulatory protein-like domains. Separating these N- and C-terminal regions is a nonhomologous glycosaminoglycan attachment region. In cartilage, aggrecan forms cartilage link protein stabilized aggregates with hyaluronan (HA). These aggregates contribute to the tissue's load bearing properties. Aggrecan and versican have a wide distribution in connective tissue and extracellular matrices. Neurocan is localized almost exclusively in nervous tissue. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. There is considerable evidence that HA-binding CSPGs are involved in developmental processes in the central nervous system. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 409379  Cd Length: 123  Bit Score: 156.22  E-value: 3.24e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2452621404  44 VAEQAKIFSHRGGNVTLPCKFYHEHTStAGSGTHKIRVKWTKLTSD--YLKEVDVFVAMG---HHRKSYGNyQGRVFLRE 118
Cdd:cd05714     1 EAESAKVFSHLGGNVTLPCKFYRDPTA-FGSGIHKIRIKWTKLTSDsgYLKEVDVLVAMGnvvYHKKTYGG-RVSVPLKP 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2452621404 119 SSENDASLIITNLILEDYGRYKCEIIEGLEDDTAVVALNLEGVVF 163
Cdd:cd05714    79 GSDSDASLVITDLTASDYGLYRCEVIEGIEDDQDVVALDVQGVVF 123
Xlink pfam00193
Extracellular link domain;
161-255 2.46e-46

Extracellular link domain;


Pssm-ID: 459706  Cd Length: 92  Bit Score: 152.73  E-value: 2.46e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2452621404 161 VVFPYSPRlGRYNLNFHEAQRACLDQDSVIASFDQLYDAWRSGLDWCNAGWLSDGSVQYPITKPREPCGGknTVPGVRNY 240
Cdd:pfam00193   1 GVFHLESP-GRYKLTFQEAQAACAALGATLATPEQLYAAWKAGLDTCDAGWLADGTVRYPITTPRPNCGG--NMPGVRQY 77

                          90
                  ....*....|....*
gi 2452621404 241 GFWDKDKSQYDVFCF 255
Cdd:pfam00193  78 GFRDPLSERYDAYCY 92
LINK smart00445
Link (Hyaluronan-binding);
159-256 1.22e-44

Link (Hyaluronan-binding);


Pssm-ID: 214667  Cd Length: 94  Bit Score: 148.64  E-value: 1.22e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2452621404  159 EGVVFPYSPRlGRYNLNFHEAQRACLDQDSVIASFDQLYDAWRSGLDWCNAGWLSDGSVQYPITKPREPCGGknTVPGVR 238
Cdd:smart00445   1 DGGVFHVEKN-GRYKLTFAEAREACRAQGATLATVGQLYAAWQDGFDTCDAGWLADGSVRYPIITPRPRCGG--NLPGVR 77

                           90
                   ....*....|....*...
gi 2452621404  239 NYGFWDKDkSQYDVFCFT 256
Cdd:smart00445  78 QYGFPDPT-SRYDAYCFN 94
LINK smart00445
Link (Hyaluronan-binding);
260-353 5.01e-39

Link (Hyaluronan-binding);


Pssm-ID: 214667  Cd Length: 94  Bit Score: 134.01  E-value: 5.01e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2452621404  260 NGRFYYLIH--PTKLTYDEAIQACVKDGAQIAKVGQIFAAWKLlGYDRCDAGWLADGSVRYPISRPRKRCSPNEAAVRFV 337
Cdd:smart00445   1 DGGVFHVEKngRYKLTFAEAREACRAQGATLATVGQLYAAWQD-GFDTCDAGWLADGSVRYPIITPRPRCGGNLPGVRQY 79

                           90
                   ....*....|....*.
gi 2452621404  338 GFPDKKHkLYGVYCFR 353
Cdd:smart00445  80 GFPDPTS-RYDAYCFN 94
Link_Domain cd01102
The link domain is a hyaluronan (HA)-binding domain. It functions to mediate adhesive ...
 161-255 6.36e-36

The link domain is a hyaluronan (HA)-binding domain. It functions to mediate adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It is found in the CD44 receptor and in human TSG-6. TSG-6 is the protein product of the tumor necrosis factor-stimulated gene-6. TSG-6 has a strong anti-inflammatory effect in models of acute inflammation and autoimmune arthritis and plays an essential role in female fertility. This group also contains the link domains of the chondroitin sulfate proteoglycan core proteins (CSPG) including aggrecan, versican, neurocan, and brevican and the link domains of the vertebrate HAPLN (HA and proteoglycan binding link) protein family. In cartilage, aggrecan forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Aggregates in which other CSPGs substitute for aggregan might contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN gene family are physically linked adjacent to CSPG genes. TSG-6 contains a single link module which supports high affinity binding with HA. The functional HA-binding domain of CD44 is an extended domain comprised of a link module flanked with N-and C- extensions. These extensions are essential for folding and functional activity. CSPGs are characterized by an N-terminal globular domain (G1 domain) containing two contiguous link modules (modules 1 and 2). Both link modules of the G1 domain of the CSPG aggrecan are involved in interaction with HA. Aggrecan in addition contains a second globular domain (G2) which contains link modules 3 and 4 which lack HA-binding activity. HAPLNs contain two contiguous link modules.


Pssm-ID: 238534  Cd Length: 92  Bit Score: 125.61  E-value: 6.36e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2452621404 161 VVFPYSPRLGRYNLNFHEAQRACLDQDSVIASFDQLYDAWRSGLDWCNAGWLSDGSVQYPITKPREPCGGKNtvPGVRNY 240
Cdd:cd01102     1 VVFHLESQNGRYKLTFAEAALACKARGAHLATPGQLEAAWQDGFDVCTAGWLADGSVRYPIVTSRPNCGGRN--PGVRSY 78

                          90
                  ....*....|....*
gi 2452621404 241 GFWDKdKSQYDVFCF 255
Cdd:cd01102    79 GNPAP-SGRYDAYCF 92
Xlink pfam00193
Extracellular link domain;
261-352 2.53e-35

Extracellular link domain;


Pssm-ID: 459706  Cd Length: 92  Bit Score: 124.22  E-value: 2.53e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2452621404 261 GRFYYlIHPT--KLTYDEAIQACVKDGAQIAKVGQIFAAWKLlGYDRCDAGWLADGSVRYPISRPRKRCSPNEAAVRFVG 338
Cdd:pfam00193   1 GVFHL-ESPGryKLTFQEAQAACAALGATLATPEQLYAAWKA-GLDTCDAGWLADGTVRYPITTPRPNCGGNMPGVRQYG 78

                          90
                  ....*....|....
gi 2452621404 339 FPDKKHKLYGVYCF 352
Cdd:pfam00193  79 FRDPLSERYDAYCY 92
Link_domain_CSPGs_modules_1_3 cd03517
Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third ...
 161-255 3.98e-35

Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: versican, neurocan, and brevican. The link domain is a hyaluronan (HA)-binding domain. CSPGs are characterized by an N-terminal globular domain (G1 domain) containing two contiguous link modules (modules 1 and 2). Both link modules of the G1 domain of aggrecan are involved in interaction with HA. In addition, aggrecan contains a second globular domain (G2) which contains link modules 3 and 4. G2 appears to lack HA-binding activity. In cartilage, aggrecan forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 239594  Cd Length: 95  Bit Score: 123.67  E-value: 3.98e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2452621404 161 VVFPYSPRLGRYNLNFHEAQRACLDQDSVIASFDQLYDAWRSGLDWCNAGWLSDGSVQYPITKPREPC-GGKNTVPGVRN 239
Cdd:cd03517     1 VVFHYRDATARYALTFPRAQRACLDISAQIATPEQLLAAYEDGFEQCDAGWLADQTVRYPIQTPREGCyGDMDGFPGVRN 80

                          90
                  ....*....|....*.
gi 2452621404 240 YGFWDKDKSqYDVFCF 255
Cdd:cd03517    81 YGVRDPDEL-YDVYCY 95
Link_domain_CSPGs_modules_2_4 cd03520
Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules ...
 264-352 3.49e-33

Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The link domain is a hyaluronan (HA)-binding domain. CSPGs are characterized by an N-terminal globular domain (G1 domain) containing two contiguous link modules (modules 1 and 2). Both link modules of the G1 domain of aggrecan are involved in interaction with HA. Aggrecan in addition contains a second globular domain (G2) having link modules 3 and 4 which lack HA-binding activity. In cartilage, aggrecan forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Aggregates having other CSPGs substituting for aggregan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 239597  Cd Length: 96  Bit Score: 118.57  E-value: 3.49e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2452621404 264 YYLIHPTKLTYDEAIQACVKDGAQIAKVGQIFAAWKLlGYDRCDAGWLADGSVRYPISRPRKRCSPNEAAVRFV------ 337
Cdd:cd03520     3 FYATAPEKFTFQEARAECRSLGAVLATTGQLYAAWRQ-GLDQCDPGWLADGSVRYPISTPRPQCGGGLPGVRTLyrfpnq 81

                          90
                  ....*....|....*.
gi 2452621404 338 -GFPDkKHKLYGVYCF 352
Cdd:cd03520    82 tGFPD-PHSRFDAYCF 96
Link_domain_CSPGs_modules_2_4 cd03520
Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules ...
 162-255 2.66e-27

Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The link domain is a hyaluronan (HA)-binding domain. CSPGs are characterized by an N-terminal globular domain (G1 domain) containing two contiguous link modules (modules 1 and 2). Both link modules of the G1 domain of aggrecan are involved in interaction with HA. Aggrecan in addition contains a second globular domain (G2) having link modules 3 and 4 which lack HA-binding activity. In cartilage, aggrecan forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Aggregates having other CSPGs substituting for aggregan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 239597  Cd Length: 96  Bit Score: 103.16  E-value: 2.66e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2452621404 162 VFpYSPRLGRynLNFHEAQRACLDQDSVIASFDQLYDAWRSGLDWCNAGWLSDGSVQYPITKPREPCGGKntVPGVR--- 238
Cdd:cd03520     2 VF-YATAPEK--FTFQEARAECRSLGAVLATTGQLYAAWRQGLDQCDPGWLADGSVRYPISTPRPQCGGG--LPGVRtly 76

                          90       100
                  ....*....|....*....|.
gi 2452621404 239 ----NYGFWDKDkSQYDVFCF 255
Cdd:cd03520    77 rfpnQTGFPDPH-SRFDAYCF 96
Link_domain_HAPLN_module_2 cd03519
Link_domain_HAPLN_module_2; this link domain is found in the second link module of proteins ...
 160-255 9.78e-27

Link_domain_HAPLN_module_2; this link domain is found in the second link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two contiguous link modules. Both link modules of cartilage link protein are involved in interaction with HA. In cartilage, a chondroitin sulfate proteoglycan core protein (CSPG) aggrecan forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Aggregates with other CSPGs substituting for aggregan may contribute to the structural integrity of many different tissues. Members of the vertebrate HAPLN gene family are physically linked adjacent to CSPG genes.


Pssm-ID: 239596  Cd Length: 91  Bit Score: 101.35  E-value: 9.78e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2452621404 160 GVVFPYSPRlgryNLNFHEAQRACLDQDSVIASFDQLYDAWR-SGLDWCNAGWLSDGSVQYPITKPREPCGGknTVPGVR 238
Cdd:cd03519     1 GVFYLLHPG----KLTFSEAVAACQRDGAQIAKVGQLFAAWKfHGLDRCDAGWLADGSVRYPISRPRPRCGP--LEPGVR 74

                          90
                  ....*....|....*..
gi 2452621404 239 NYGFWDKDKSQYDVFCF 255
Cdd:cd03519    75 SFGFPDKKHKLYGVYCY 91
Link_Domain cd01102
The link domain is a hyaluronan (HA)-binding domain. It functions to mediate adhesive ...
 252-352 2.67e-25

The link domain is a hyaluronan (HA)-binding domain. It functions to mediate adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It is found in the CD44 receptor and in human TSG-6. TSG-6 is the protein product of the tumor necrosis factor-stimulated gene-6. TSG-6 has a strong anti-inflammatory effect in models of acute inflammation and autoimmune arthritis and plays an essential role in female fertility. This group also contains the link domains of the chondroitin sulfate proteoglycan core proteins (CSPG) including aggrecan, versican, neurocan, and brevican and the link domains of the vertebrate HAPLN (HA and proteoglycan binding link) protein family. In cartilage, aggrecan forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Aggregates in which other CSPGs substitute for aggregan might contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN gene family are physically linked adjacent to CSPG genes. TSG-6 contains a single link module which supports high affinity binding with HA. The functional HA-binding domain of CD44 is an extended domain comprised of a link module flanked with N-and C- extensions. These extensions are essential for folding and functional activity. CSPGs are characterized by an N-terminal globular domain (G1 domain) containing two contiguous link modules (modules 1 and 2). Both link modules of the G1 domain of the CSPG aggrecan are involved in interaction with HA. Aggrecan in addition contains a second globular domain (G2) which contains link modules 3 and 4 which lack HA-binding activity. HAPLNs contain two contiguous link modules.


Pssm-ID: 238534  Cd Length: 92  Bit Score: 97.87  E-value: 2.67e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2452621404 252 VFCFTSNfNGRFyylihptKLTYDEAIQACVKDGAQIAKVGQIFAAWKLlGYDRCDAGWLADGSVRYPISRPRKRCSPNE 331
Cdd:cd01102     2 VFHLESQ-NGRY-------KLTFAEAALACKARGAHLATPGQLEAAWQD-GFDVCTAGWLADGSVRYPIVTSRPNCGGRN 72

                          90       100
                  ....*....|....*....|.
gi 2452621404 332 AAVRFVGFPDKKhKLYGVYCF 352
Cdd:cd01102    73 PGVRSYGNPAPS-GRYDAYCF 92
Link_domain_CSPGs_modules_1_3 cd03517
Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third ...
 263-352 4.13e-20

Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: versican, neurocan, and brevican. The link domain is a hyaluronan (HA)-binding domain. CSPGs are characterized by an N-terminal globular domain (G1 domain) containing two contiguous link modules (modules 1 and 2). Both link modules of the G1 domain of aggrecan are involved in interaction with HA. In addition, aggrecan contains a second globular domain (G2) which contains link modules 3 and 4. G2 appears to lack HA-binding activity. In cartilage, aggrecan forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 239594  Cd Length: 95  Bit Score: 84.00  E-value: 4.13e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2452621404 263 FYYLIHPTK--LTYDEAIQACVKDGAQIAKVGQIFAAWkLLGYDRCDAGWLADGSVRYPISRPRKRCSPNE---AAVRFV 337
Cdd:cd03517     3 FHYRDATARyaLTFPRAQRACLDISAQIATPEQLLAAY-EDGFEQCDAGWLADQTVRYPIQTPREGCYGDMdgfPGVRNY 81

                          90
                  ....*....|....*
gi 2452621404 338 GFPDKKhKLYGVYCF 352
Cdd:cd03517    82 GVRDPD-ELYDVYCY 95
Link_domain_TSG_6_like cd03515
This is the extracellular link domain of the type found in human TSG-6. The link domain is a ...
 162-255 4.37e-19

This is the extracellular link domain of the type found in human TSG-6. The link domain is a hyaluronan (HA)-binding domain. TSG-6 is the protein product of tumor necrosis factor-stimulated gene-6. TSG-6 is up-regulated in inflammatory lesions and in the ovary during ovulation. It has a strong anti-inflammatory and chondroprotective effect in models of acute inflammation and autoimmune arthritis and plays an essential role in female fertility. Also included in this group are the stabilins: stabilin-1 (FEEL-1, CLEVER-1) and stabilin-2 (FEEL-2). Stabilin-2 functions as the major liver and lymph node-scavenging receptor for HA and related glycosaminoglycans. Stabilin-2 is a scavenger receptor with a broad range of ligands including advanced glycation end (AGE) products, acetylated low density lipoprotein and procollagen peptides. In contrast, stabilin-1 does not bind HA, but binds acetylated low density lipoprotein and AGEs with lower affinity. As AGEs accumulate in vascular tissues during aging and diabetes, these receptors may be implicated in the pathologies of these states. Both stabilins are present in the early endocytic pathway in hepatic sinusoidal epithelium associating with clathrin/AP-2. Stabilin-1 is expressed in macrophages. Stabilin-2 is absent from the latter. In macrophages: stabilin-1 is involved in trafficking between early/sorting endosomes and the trans-Golgi network. Stabilin-1 has also been implicated in angiogenesis and possibly leucocyte trafficking. Both stabilins bind gram-positive and gram-negative bacteria. TSG-6 and stabilins contain a single link module which supports high affinity binding to HA.


Pssm-ID: 239592  Cd Length: 93  Bit Score: 80.97  E-value: 4.37e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2452621404 162 VFPYSPRLGRYNLNFHEAQRACLDQDSVIASFDQLYDAWRSGLDWCNAGWLSDGSVQYPITKPREPCGgkNTVPGVRNYG 241
Cdd:cd03515     2 VFHLRSRSGKYKLTYTEAKAACEAEGAHLATYSQLSAAQQLGFHLCAAGWLAKGRVGYPIVFPSANCG--FGHVGIVDYG 79

                          90
                  ....*....|....
gi 2452621404 242 FWDKDKSQYDVFCF 255
Cdd:cd03515    80 PRLNLSERWDAYCY 93
Ig_Aggrecan_like cd05878
Immunoglobulin (Ig)-like domain of the aggrecan-like chondroitin sulfate proteoglycan core ...
 55-163 1.12e-16

Immunoglobulin (Ig)-like domain of the aggrecan-like chondroitin sulfate proteoglycan core protein (CSPG); The members here are composed of the immunoglobulin (Ig)-like domain of the aggrecan-like chondroitin sulfate proteoglycan core proteins (CSPGs). Included in this group are the Ig domains of other CSPGs: versican, and neurocan. In CSPGs, this Ig-like domain is followed by hyaluronan (HA)-binding tandem repeats, and a C-terminal region with epidermal growth factor-like, lectin-like, and complement regulatory protein-like domains. Separating these N- and C-terminal regions is a nonhomologous glycosaminoglycan attachment region. In cartilage, aggrecan forms cartilage link protein stabilized aggregates with hyaluronan (HA). These aggregates contribute to the tissue's load bearing properties. Aggrecan and versican have a wide distribution in connective tissue and extracellular matrices. Neurocan is localized almost exclusively in nervous tissue. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 409462  Cd Length: 125  Bit Score: 75.35  E-value: 1.12e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2452621404  55 GGNVTLPCKFYHE-HTSTAGSGTHKIRVKWTKLTSDY--LKEVDVFVAMGHHRKSYGNYQGRVFLRESSE--NDASLIIT 129
Cdd:cd05878    12 GTSVTLPCYFIDPpHPVTPSTAPLAPRIKWSKVSVDGkkEKEVVLLVATEGRVRVNSAYQGRVSLPNYPAipSDATLEVQ 91

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2452621404 130 NLILEDYGRYKCEIIEGLEDDTAVVALNLEGVVF 163
Cdd:cd05878    92 SLRASDSGLYRCEVMHGIEDSQDTVELVVKGVVF 125
Ig_Versican cd05901
Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), ...
 56-163 1.92e-16

Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), versican; The members here are composed of the immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), versican. In CSPGs, the Ig-like domain is followed by hyaluronan (HA)-binding tandem repeats, and a C-terminal region with epidermal growth factor-like, lectin-like, and complement regulatory protein-like domains. Separating these N- and C-terminal regions is a nonhomologous glycosaminoglycan attachment region. In cartilage, the CSPG aggrecan (not included in this group) forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Like aggrecan, versican has a wide distribution in connective tissue and extracellular matrices. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 409482  Cd Length: 128  Bit Score: 75.00  E-value: 1.92e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2452621404  56 GNVTLPCKFYHEHTSTAGSGTHK--IRVKWTKLTSDY----LKEVDVFVAMGHHRKSYGNYQGRVFLRESSEN--DASLI 127
Cdd:cd05901    13 GSVVLPCRFSTLPTLPPSYNITSefLRIKWTKIQVDKngkdHKETTVLVAQNGIIKIGQEYMGRVSVPSHPEDqgDASLT 92

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2452621404 128 ITNLILEDYGRYKCEIIEGLEDDTAVVALNLEGVVF 163
Cdd:cd05901    93 IVKLRASDAGVYRCEVMHGIEDTQDTVSLDVSGVVF 128
Link_domain_TSG_6_like cd03515
This is the extracellular link domain of the type found in human TSG-6. The link domain is a ...
 269-352 1.96e-14

This is the extracellular link domain of the type found in human TSG-6. The link domain is a hyaluronan (HA)-binding domain. TSG-6 is the protein product of tumor necrosis factor-stimulated gene-6. TSG-6 is up-regulated in inflammatory lesions and in the ovary during ovulation. It has a strong anti-inflammatory and chondroprotective effect in models of acute inflammation and autoimmune arthritis and plays an essential role in female fertility. Also included in this group are the stabilins: stabilin-1 (FEEL-1, CLEVER-1) and stabilin-2 (FEEL-2). Stabilin-2 functions as the major liver and lymph node-scavenging receptor for HA and related glycosaminoglycans. Stabilin-2 is a scavenger receptor with a broad range of ligands including advanced glycation end (AGE) products, acetylated low density lipoprotein and procollagen peptides. In contrast, stabilin-1 does not bind HA, but binds acetylated low density lipoprotein and AGEs with lower affinity. As AGEs accumulate in vascular tissues during aging and diabetes, these receptors may be implicated in the pathologies of these states. Both stabilins are present in the early endocytic pathway in hepatic sinusoidal epithelium associating with clathrin/AP-2. Stabilin-1 is expressed in macrophages. Stabilin-2 is absent from the latter. In macrophages: stabilin-1 is involved in trafficking between early/sorting endosomes and the trans-Golgi network. Stabilin-1 has also been implicated in angiogenesis and possibly leucocyte trafficking. Both stabilins bind gram-positive and gram-negative bacteria. TSG-6 and stabilins contain a single link module which supports high affinity binding to HA.


Pssm-ID: 239592  Cd Length: 93  Bit Score: 68.26  E-value: 1.96e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2452621404 269 PTKLTYDEAIQACVKDGAQIAKVGQIFAAWKLlGYDRCDAGWLADGSVRYPISRPRKRCSPNEAAVRFVGFPDKKHKLYG 348
Cdd:cd03515    11 KYKLTYTEAKAACEAEGAHLATYSQLSAAQQL-GFHLCAAGWLAKGRVGYPIVFPSANCGFGHVGIVDYGPRLNLSERWD 89


                  ....
gi 2452621404 349 VYCF 352
Cdd:cd03515    90 AYCY 93
Ig_Neurocan cd05902
Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), ...
 56-163 4.35e-14

Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), neurocan; The members here are composed of the immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), neurocan. In CSPGs, the Ig-like domain is followed by hyaluronan (HA)-binding tandem repeats, and a C-terminal region with epidermal growth factor-like, lectin-like, and complement regulatory protein-like domains. Separating these N- and C-terminal regions is a nonhomologous glycosaminoglycan attachment region. In cartilage, the CSPG aggrecan (not included in this group) forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Unlike aggrecan which is widely distributed in connective tissue and extracellular matrices, neurocan is localized almost exclusively in nervous tissue. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 409483  Cd Length: 121  Bit Score: 67.94  E-value: 4.35e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2452621404  56 GNVTLPCKFYHEhtSTAGSGTHKIRVKWTKLTSDYL-KEVDVFVAMGHHRKSYGNYQGRVFLRESSEN--DASLIITNLI 132
Cdd:cd05902    13 SSVLLPCVFTLP--PSASSPPEGPRIKWTKLSTSGGqQQRPVLVARDNVVRVAKAFQGRVSLPGYPKNryNASLVLSRLR 90

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2452621404 133 LEDYGRYKCEIIEGLEDDTAVVALNLEGVVF 163
Cdd:cd05902    91 YSDSGTYRCEVVLGINDEQDTVPLEVTGVVF 121
Ig_Aggrecan cd05900
Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), ...
 55-163 1.32e-12

Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), aggrecan; The members here are composed of the immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), aggrecan. In CSPGs, the Ig-like domain is followed by hyaluronan (HA)-binding tandem repeats, and a C-terminal region with epidermal growth factor-like, lectin-like, and complement regulatory protein-like domains. Separating these N- and C-terminal regions is a nonhomologous glycosaminoglycan attachment region. In cartilage, aggrecan forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Aggrecan has a wide distribution in connective tissue and extracellular matrices. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 409481  Cd Length: 123  Bit Score: 63.80  E-value: 1.32e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2452621404  55 GGNVTLPCKF---YHEHTSTAGSGTHKIRVKWTKLTSDylKEVDVFVAMGHHRKSYGNYQGRVFLRE--SSENDASLIIT 129
Cdd:cd05900    12 GSSLLIPCYFqdpIAKDPGAPTVAPLSPRIKWSFISKE--KESVLLVATEGKVRVNTEYLDRVSLPNypAIPSDATLEIT 89

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2452621404 130 NLILEDYGRYKCEIIEGLEDDTAVVALNLEGVVF 163
Cdd:cd05900    90 ELRSNDSGTYRCEVMHGIEDNYDTVEVQVKGIVF 123
Link_domain_CD44_like cd03516
This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates ...
 170-257 1.45e-09

This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding domain of CD44 is an extended domain comprised of a single link module flanked with N-and C- extensions. These extensions are essential for folding and for functional activity. This group also contains the cell surface retention sequence (CRS) binding protein-1 (CRSBP-1) and lymph vessel endothelial receptor-1 (LYVE-1). CRSBP-1 is a cell surface binding protein for the CRS motif of PDGF-BB (platelet-derived growth factor-BB) and is responsible for the cell surface retention of PDGF-BB in SSV-transformed cells. CRSBP-1 may play a role in autocrine regulation of cell growth mediated by CRS containing growth regulators. LYVE-1 is preferentially expressed on the lymphatic endothelium and is used as a molecular marker for the detection and characterization of lymphatic vessels in tumors.


Pssm-ID: 239593  Cd Length: 144  Bit Score: 55.93  E-value: 1.45e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2452621404 170 GRYNLNFHEAQRACLDQDSVIASFDQLYDAWRSGLDWCNAGWLSDGSVQYPITKPREPCGGKNTvpGVrnYGFWDKDKSQ 249
Cdd:cd03516    15 GRYSLNFTEAKEACRALGLTLASKAQVETALKFGFETCRYGWVEDGFVVIPRIDPNPLCGKNGT--GV--YILNSNLSSR 90


                  ....*...
gi 2452621404 250 YDVFCFTS 257
Cdd:cd03516    91 YDAYCYNS 98
IGv smart00406
Immunoglobulin V-Type;
57-143 4.14e-09

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 52.77  E-value: 4.14e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2452621404   57 NVTLPCKFYhehtstaGSGTHKIRVKWTKLTSDylKEVDVFVAMGHHRKSYGN--YQGRV-FLRESSENDASLIITNLIL 133
Cdd:smart00406   1 SVTLSCKFS-------GSTFSSYYVSWVRQPPG--KGLEWLGYIGSNGSSYYQesYKGRFtISKDTSKNDVSLTISNLRV 71

                           90
                   ....*....|
gi 2452621404  134 EDYGRYKCEI 143
Cdd:smart00406  72 EDTGTYYCAV 81
IgV_CAR_like cd20960
Immunoglobulin Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and ...
 55-143 1.04e-08

Immunoglobulin Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and similar proteins; The members here are composed of the Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and similar proteins. CAR, which is encoded by human CXADR gene, is a cell adhesion molecule of the Immunoglobulin (Ig) superfamily. The CAR acts as a type I membrane receptor for group B1-B6 coxsackie viruses and subgroup C adenoviruses. For instance, adenovirus interacts with the coxsackievirus and adenovirus receptor to enter epithelial airway cells. The CAR is also shown to be involved in physiological processes such as neuronal and heart development, epithelial tight junction integrity, and tumor suppression. The CAR is a component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. The CAR is also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. The CAR is composed of one V-set and one C2-set Ig module, a single transmembrane helix, and an intracellular domain. This group belongs to the V-set of IgSF domains, having A, B, E and D strands in one beta-sheet and A', G, F, C, C' and C" in the other


Pssm-ID: 409552  Cd Length: 114  Bit Score: 52.84  E-value: 1.04e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2452621404  55 GGNVTLPCKFyheHTSTAGSGTHKIrvKWTKLTSDYLKEVDVFVAMGH-HRKSYGNYQGRV-FLRESSENDASLIITNLI 132
Cdd:cd20960    15 GENVTLPCHH---QLGLEDQGTLDI--EWLLLPSDKVEKVVITYSGDRvYNHYYPALKGRVaFTSNDLSGDASLNISNLK 89

                          90
                  ....*....|.
gi 2452621404 133 LEDYGRYKCEI 143
Cdd:cd20960    90 LSDTGTYQCKV 100
IgV_1_PVR_like cd05718
First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 ...
 55-143 6.13e-08

First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 and necl-5), and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155 and nectin-like protein 5 (necl-5)). Poliovirus (PV) binds to its cellular receptor (PVR/CD155) to initiate infection. CD155 is a membrane-anchored, single-span glycoprotein; its extracellular region has three Ig-like domains. There are four different isotypes of CD155 (referred to as alpha, beta, gamma, and delta), that result from alternate splicing of the CD155 mRNA, and have identical extracellular domains. CD155-beta and CD155-gamma are secreted; CD155-alpha and CD155-delta are membrane-bound and function as PV receptors. The virus recognition site is contained in the amino-terminal domain, D1. Having the virus attachment site on the receptor distal from the plasma membrane may be important for successful initiation of infection of cells by the virus. CD155 binds in the poliovirus "canyon" with a footprint similar to that of the intercellular adhesion molecule-1 receptor on human rhinoviruses. This group also includes the first Ig-like domain of nectin-1 (also known as poliovirus receptor related protein(PVRL)1; CD111), nectin-3 (also known as PVRL 3), nectin-4 (also known as PVRL4; LNIR receptor)and DNAX accessory molecule 1 (DNAM-1; CD226).


Pssm-ID: 409383  Cd Length: 113  Bit Score: 50.52  E-value: 6.13e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2452621404  55 GGNVTLPCKFyhehtstAGSGTHKI-RVKWTKLTSDYLKEVDVF-VAMGHHRKsyGNYQGRV-FLRESSE-NDASLIITN 130
Cdd:cd05718    14 GGSVTLPCSL-------TSPGTTKItQVTWMKIGAGSSQNVAVFhPQYGPSVP--NPYAERVeFLAARLGlRNATLRIRN 84

                          90
                  ....*....|...
gi 2452621404 131 LILEDYGRYKCEI 143
Cdd:cd05718    85 LRVEDEGNYICEF 97
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 38-144 1.04e-06

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 46.68  E-value: 1.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2452621404  38 GPRLLVVAEqakifshrGGNVTLPCKFyheHTSTAGSGThkiRVKWTKLTSDYLKEVDVFVAmghhRKSYGN--YQGRVF 115
Cdd:pfam07686   2 TPREVTVAL--------GGSVTLPCTY---SSSMSEAST---SVYWYRQPPGKGPTFLIAYY----SNGSEEgvKKGRFS 63

                          90       100       110
                  ....*....|....*....|....*....|
gi 2452621404 116 LRES-SENDASLIITNLILEDYGRYKCEII 144
Cdd:pfam07686  64 GRGDpSNGDGSLTIQNLTLSDSGTYTCAVI 93
IgV_B7-H6 cd20981
Immunoglobulin variable (IgV) domain of B7-H6; The members here are composed of the ...
 52-144 7.76e-06

Immunoglobulin variable (IgV) domain of B7-H6; The members here are composed of the immunoglobulin variable (IgV) domain of B7-H6 (also known as NCR3LG1). B7-H6 contains one IgV domain and one IgC domain (IgV-IgC) and belongs to the B7-family, which consists of structurally related cell-surface protein ligands which bind to receptors on lymphocytes that regulate immune responses. B7-H6 is a ligand of NKp30, which is a member of CD28 family and an activating receptor of natural killer (NK) cells. The expression of NKp30 has been found in most of NK cells, which is involved in the process of tumor cell killing and interaction with antigen presenting cells (APCs) such as dendritic cells. Studies showed that NK cells eliminate B7-H6-expressing tumor cells either directly via cytotoxicity or indirectly by cytokine secretion. For instance, chimeric NKp30-expressing T cells responded to B7-H6(+) tumor cells and those T cells produced IFN-gamma and killed B7-H6-expressing tumor cells in vivo. B7-H6 mRNA is not found in normal cells, while high expression of B7-H6 is found in certain type tumor cells, such as lymphoma, leukemia, ovarian cancer, brain tumors, breast cancers, and various sarcomas. Since B7-H6 can bind NKp30 to exert anti-tumor effects by NK cells, which are able to recognize the difference between cancer cells and normal cells, B7-H6 may serve as a promising target for cancer immunotherapy.


Pssm-ID: 409573  Cd Length: 114  Bit Score: 44.52  E-value: 7.76e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2452621404  52 SHRGGNVTLPCKFYhehtstaGSGTHKIRVK-----WTKLTSDylKEVDVFVAMGHHRKSYgNYQGRVFLRESSENDASL 126
Cdd:cd20981    13 TPLNDNVTIFCNIF-------YSQPLNITSMgitwfRKSLTFD--KEVKVFEFFGDHQKAF-RPGAIVSPWRLKSGDASL 82

                          90
                  ....*....|....*...
gi 2452621404 127 IITNLILEDYGRYKCEII 144
Cdd:cd20981    83 QLPGVQLEEAGEYRCEVV 100
IgV_CRIg cd16089
Immunoglobulin variable (IgV)-like domain in complement receptor of the immunoglobulin ...
 56-143 1.11e-05

Immunoglobulin variable (IgV)-like domain in complement receptor of the immunoglobulin superfamily (CRIg); The members here are composed of the immunoglobulin variable (IgV) region of the complement receptor of the immunoglobulin superfamily (CRIg). The N-terminal domain of CRIg (also known as Z39Ig and V-set and Ig domain-containing 4 (VSIG4) belongs to the IgV family of immunoglobulin-like domains while the C-terminal domain of CRIg belongs to the IgC family of immunoglobulin-like domains. Like all members of this family, the CRIg domain contains two beta-sheets: one composed of strands A', G, F, C, C' and C", and the other of strands B, E and D. The complement system is an important part of the innate immune system and is required for removal of pathogens from the bloodstream. After exposure to pathogens, the third component of the complement system, C3, is cleaved to C3b which, after recruitment of factor B, initiates formation of the alternative pathway convertases. CRIg, a complement receptor expressed on macrophages, binds to C3b and iC3b mediating phagocytosis of the particles. It is also a potent inhibitor of the alternative pathway convertases and a negative regulator of T cell activation. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, such as, T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, such as, butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond.


Pssm-ID: 409510  Cd Length: 117  Bit Score: 44.05  E-value: 1.11e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2452621404  56 GNVTLPCKFYHEhtstagSGTHKIRVKWTkLTSDYlKEVDVFVamghhRKSYGN------YQGRVFLRESSENDASLIIT 129
Cdd:cd16089    15 GSVNLPCTYVPE------EGYTQVLVKWL-VQRDS-DPVTIFL-----RDSSGDhiqqakYRGRLEVSKDTPGDVSLQLD 81

                          90
                  ....*....|....
gi 2452621404 130 NLILEDYGRYKCEI 143
Cdd:cd16089    82 TLEMDDRGHYTCQV 95
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 55-156 1.44e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 42.88  E-value: 1.44e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2452621404   55 GGNVTLPCKFyhehtstagSGTHKIRVKWTKltsDYLKEVdvfvamghhrksygNYQGRVFLRESSeNDASLIITNLILE 134
Cdd:smart00410   9 GESVTLSCEA---------SGSPPPEVTWYK---QGGKLL--------------AESGRFSVSRSG-STSTLTISNVTPE 61

                           90       100
                   ....*....|....*....|..
gi 2452621404  135 DYGRYKCEIIEGLEDDTAVVAL 156
Cdd:smart00410  62 DSGTYTCAATNSSGSASSGTTL 83
IgV_1_Nectin-4_like cd05888
First immunoglobulin (Ig) domain of nectin-4, and similar domains; The members here are ...
 55-144 2.63e-05

First immunoglobulin (Ig) domain of nectin-4, and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of nectin-4 (also known as poliovirus receptor related protein 4 or LNIR receptor). Nectin-4 belongs to the nectin family, which is comprised of four transmembrane glycoproteins (nectins-1 through -4). Nectins are synaptic cell adhesion molecules (CAMs) which participate in adhesion and signaling at various intracellular junctions. Nectins form homophilic cis-dimers, followed by homophilic and heterophilic trans-dimers involved in cell-cell adhesion. For example nectin-4 trans-interacts with nectin-1. Nectin-4 has also been shown to interact with the actin filament-binding protein, afadin. Unlike the other nectins, which are widely expressed in adult tissues, nectin-4 is mainly expressed during embryogenesis, and is not detected in normal adult tissue or in serum. Nectin-4 is re-expressed in breast carcinoma, and patients having metastatic breast cancer have a circulating form of nectin-4 formed from the ectodomain


Pssm-ID: 409471  Cd Length: 108  Bit Score: 42.96  E-value: 2.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2452621404  55 GGNVTLPCKFyhehtsTAGSGTHKIRVKWTKLTSDylkEVDVFVAMGHHRKS---YGNYQGRVflRESSEN---DASLII 128
Cdd:cd05888     8 GQDAKLPCFY------RGDSGEQVGQVAWARVDAG---EGAQEIALLHSKYGlhvFPAYEGRV--EQPPPPrpaDGSVLL 76

                          90
                  ....*....|....*.
gi 2452621404 129 TNLILEDYGRYKCEII 144
Cdd:cd05888    77 RNAVQADEGEYECRVS 92
IgV_1_Nectin-2_NecL-5_like_CD112_CD155 cd20989
First immunoglobulin variable (IgV) domain of nectin-2, nectin-like protein 5, and similar ...
 55-143 4.63e-05

First immunoglobulin variable (IgV) domain of nectin-2, nectin-like protein 5, and similar domains; The members here are composed of the second immunoglobulin (Ig) domain of nectin-2 (also known as poliovirus receptor related protein 2 or Cluster of Differentiation 112 (CD112)), nectin-like protein 5 (CD155), and similar proteins. Nectins and Nectin-like molecules are a family of Ca(2+)-independent immunoglobulin-like transmembrane glycoproteins belonging to the class of adhesion receptors, consisting of nine members (nectins 1 through 4 and nectin-like proteins 1 through 5). Nectins are synaptic cell adhesion molecules (CAMs) which facilitate adhesion and signaling at various intracellular junctions. Nectins form homophilic cis-dimers, followed by homophilic and heterophilic trans-dimers involved in cell-cell adhesion. Nectin-2 and nectin-3 localize at Sertoli-spermatid junctions where they form heterophilic trans-interactions between the cells that are essential for the formation and maintenance of the junctions and for spermatid development. CD155 is the fifth member in the nectin-like molecule family, and functions as the receptor of poliovirus; therefore, CD155 is also referred to as Necl-5, or PVR. In contrast to all other family members, CD155 lacks self-adhesion capacity, yet it shares with nectins the feature to interact with other nectins. For instance, CD155 heterophilically trans-interacts with nectin-3, thereby contributing significantly to the establishment of adherens junctions between epithelial cells. This group belongs to the Constant 1 (C1)-set of IgSF domains, which has one beta-sheet that is formed by strands A-B-E-D and the other strands by G-F-C-C'.


Pssm-ID: 409581  Cd Length: 112  Bit Score: 42.18  E-value: 4.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2452621404  55 GGNVTLPCkfyheHTSTAGSGTHKIRVKWTKLTSDYLkevdvfVAMGHHRK--SYGNYQGRVFLRESSE---NDASLIIT 129
Cdd:cd20989    14 GGSVTLPC-----HLLPPNMVTHVSQVTWQRHDEHGS------VAVFHPKQgpSFPESERLSFVAARLGaelRNASLAMF 82

                          90
                  ....*....|....
gi 2452621404 130 NLILEDYGRYKCEI 143
Cdd:cd20989    83 GLRVEDEGNYTCEF 96
IgV_1_Nectin-3_like cd05887
First immunoglobulin variable (IgV) domain of nectin-3 (also known as poliovirus receptor ...
 55-144 1.31e-04

First immunoglobulin variable (IgV) domain of nectin-3 (also known as poliovirus receptor related protein 3), and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of nectin-3 (also known as poliovirus receptor related protein 3 (PVRL3) or cluster of differentiation (CD) 113). Nectin-3 belongs to the nectin family comprised of four transmembrane glycoproteins (nectins-1 through -4). Nectins are synaptic cell adhesion molecules (CAMs) which participate in adhesion and signaling at various intracellular junctions. Nectins form homophilic cis-dimers, followed by homophilic and heterophilic trans-dimers involved in cell-cell adhesion. For example, during spermatid development, the nectin-3,-2 trans-interaction is required for the formation of Sertoli cell-spermatid junctions in testis, and during morphogenesis of the ciliary body, the nectin-3,-1 trans-interaction is important for apex-apex adhesion between the pigment and non-pigment layers of the ciliary epithelia. Nectins also heterophilically trans-interact with other CAMs such as nectin-like molecules (Necls); nectin-3 for example, trans-interacts with Necl-5, regulating cell movement and proliferation. Other proteins with which nectin-3 interacts include the actin filament-binding protein, afadin, integrin alpha-beta3, Par-3, and PDGF receptor; its interaction with PDGF receptor regulates the latter's signaling for anti-apoptosis.


Pssm-ID: 409470  Cd Length: 110  Bit Score: 40.69  E-value: 1.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2452621404  55 GGNVTLPCKFYHEHTSTagsgthkiRVKWTKLTSDYLKEVDVfvamghHRKSYG-----NYQGRVFLRESSENDASLIIT 129
Cdd:cd05887    14 GKNVSLKCLIEVNETIT--------QISWEKIHGKSSQTVAV------HHPQYGisiqgEYQGRVSFKNYSLNDATITLH 79

                          90
                  ....*....|....*
gi 2452621404 130 NLILEDYGRYKCEII 144
Cdd:cd05887    80 NVGFSDSGKYICKAV 94
IgV_P0-like cd05715
Immunoglobulin (Ig)-like domain of protein zero (P0) and similar proteins; The members here ...
 42-143 1.54e-04

Immunoglobulin (Ig)-like domain of protein zero (P0) and similar proteins; The members here are composed of the immunoglobulin (Ig) domain of protein zero (P0), a myelin membrane adhesion molecule. P0 accounts for over 50% of the total protein in peripheral nervous system (PNS) myelin. P0 is a single-pass transmembrane glycoprotein with a highly basic intracellular domain and an extracellular Ig domain. The extracellular domain of P0 (P0-ED) is similar to the Ig variable domain, carrying one acceptor sequence for N-linked glycosylation. P0 plays a role in membrane adhesion in the spiral wraps of the myelin sheath. The intracellular domain is thought to mediate membrane apposition of the cytoplasmic faces and may, through electrostatic interactions, interact directly with lipid headgroups. It is thought that homophilic interactions of the P0 extracellular domain mediate membrane juxtaposition in the extracellular space of PNS myelin. This group also contains the Ig domain of sodium channel subunit beta-2 (SCN2B), and of epithelial V-like antigen 1 (EVA). EVA, also known as myelin protein zero-like 2, is an adhesion molecule, which may play a role in structural organization of the thymus and early lymphocyte development. SCN2B subunits play a role in determining sodium channel density and function in neurons,and in control of electrical excitability in the brain.


Pssm-ID: 409380  Cd Length: 117  Bit Score: 40.87  E-value: 1.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2452621404  42 LVVAEQAKIFSHRGGNVTLPCKFyhehTSTAGSGThKIRVKWTKLTSDYLKEVDVFvaMGHHRKSY----GNYQGRV-FL 116
Cdd:cd05715     1 MEVYTPRELNVLNGSDVRLTCTF----TSCYTVGD-AFSVTWTYQPEGGNTTESMF--HYSKGKPYilkvGRFKDRVsWA 73

                          90       100
                  ....*....|....*....|....*..
gi 2452621404 117 RESSENDASLIITNLILEDYGRYKCEI 143
Cdd:cd05715    74 GNPSKKDASIVISNLQFSDNGTYTCDV 100
IgV_VCBP cd20963
Immunoglobulin Variable region-containing chitin-binding proteins; an immunoglobulin V-set ...
 53-145 5.66e-04

Immunoglobulin Variable region-containing chitin-binding proteins; an immunoglobulin V-set domain; The members here are composed of the immunoglobulin variable (IgV) region-containing chitin-binding proteins (VCBPs). VCBPs are secreted, immune-type molecules that have been identified in both amphioxus and sea squirt (Ciona intestinalis). VCBPs, which consist of a leader peptide, two tandem N-terminal immunoglobulin V-type domains and a single C-terminal chitin-binding domain, belong to a multigene family encoding secreted proteins. The VCBPs were identified first in the cephalochordate Branchiostoma floridae and show structural similarities with V-type domains of immunoglobulins and T cell receptors, suggesting that VCBPs represent a unique gut-associated form of innate immune proteins. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, such as, T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, such as, butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. This group belongs to the V-set of IgSF domains, having A, B, E and D strands in one beta-sheet and A', G, F, C, C' and C" in the other.


Pssm-ID: 409555  Cd Length: 123  Bit Score: 39.52  E-value: 5.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2452621404  53 HRGGNVTLPCKFyhehtsTAGSGTHKIRVKWTKLTSD------YLKEVDVFVAMGHHRKSYGNYQGRVFLreSSENDASL 126
Cdd:cd20963    15 TWGNRVELPCSY------TISPAAQPPTITWLKGISVdraevvFKGFKYWNETSSSGEVYFGDYAGRASV--ASLTQPTL 86

                          90
                  ....*....|....*....
gi 2452621404 127 IITNLILEDYGRYKCEIIE 145
Cdd:cd20963    87 VLTDLKFDDWGRYWCRVAN 105
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 58-142 1.51e-03

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 36.92  E-value: 1.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2452621404  58 VTLPCKFyhehtstagSGTHKIRVKWTKLTSDylkevdvfvamghhrksygNYQGRVFLRESSENDASLIITNLILEDYG 137
Cdd:cd00096     1 VTLTCSA---------SGNPPPTITWYKNGKP-------------------LPPSSRDSRRSELGNGTLTISNVTLEDSG 52


                  ....*
gi 2452621404 138 RYKCE 142
Cdd:cd00096    53 TYTCV 57
Ig_SLAM-like_N cd16842
N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule ...
 109-144 2.85e-03

N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family and similar proteins. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. Members of this group include proteins such as CD84, SLAM (CD150), Ly-9 (CD229), NTB-A (ly-108, SLAM6), 19A (CRACC), and SLAMF9. The genes coding for the SLAM family are nested on chromosome 1, in humans at 1q23, and in mice at 1H2. The SLAM family is a subset of the CD2 family, which also includes CD2 and CD58 located on chromosome 1 at 1p13 in humans. In mice, CD2 is located on chromosome 3, and there is no CD58 homolog. The SLAM family proteins are organized as an extracellular domain with either two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having Tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.


Pssm-ID: 409517  Cd Length: 102  Bit Score: 36.91  E-value: 2.85e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2452621404 109 NYQGRVflrESSENDASLIITNLILEDYGRYKCEII 144
Cdd:cd16842    53 SYKERL---NISQNDYSLQISNLTMEDAGSYRARIN 85
IgV_HHLA2 cd16091
Immunoglobulin Variable (IgV) domain in HERV-H LTR-associating 2 (HHLA2); The members here are ...
 57-141 4.37e-03

Immunoglobulin Variable (IgV) domain in HERV-H LTR-associating 2 (HHLA2); The members here are composed of the immunoglobulin variable (IgV) region in HERV-H LTR-associating 2 (HHLA2; also known as B7-H7/B7 homolog 7). HHLA2 is a member of the B7 family of immune regulatory proteins. Mature human HHLA2 consists of an extracellular domain (ECD) with three immunoglobulin-like domains, a transmembrane segment, and a cytoplasmic domain. HHLA2 is widely expressed in human cancers including non-small cell lung carcinoma (NSCLS), triple negative breast cancer (TNBC), and melanoma, but has limited expression on normal tissues. Interestingly, unlike other members of B7 family, HHLA2 is not expressed in mice or rats. HHLA2 functions as a T cell coinhibitory molecules as it inhibits the proliferation of activated CD4(+) and CD8(+) T cells and their cytokine production. Furthermore, HHLA2 is constitutively expressed on the surface of human monocytes and is induced on B cells after stimulation, however it is not inducible on T cells.


Pssm-ID: 409512  Cd Length: 107  Bit Score: 36.60  E-value: 4.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2452621404  57 NVTLPCKFyhehtstagSGTHKIRVKWTKLTSDYLkeVDVFVAMGHHRKSYGN-YQGR--VFLRESSENDASLIITNLIL 133
Cdd:cd16091    14 DCILPCSF---------TPGSEVVIHWYKQDSDIK--VHSYYYGKDQLESQDQrYRNRtsLFKDQISNGNASLLLRRVQL 82


                  ....*...
gi 2452621404 134 EDYGRYKC 141
Cdd:cd16091    83 QDEGRYKC 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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