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Conserved domains on  [gi|2462566445|ref|XP_054177501|]
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RNA exonuclease 1 homolog isoform X3 [Homo sapiens]

Protein Classification

EloA-BP1 and REX1_like domain-containing protein( domain architecture ID 13315180)

protein containing domains PTZ00449, EloA-BP1, and REX1_like

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EloA-BP1 pfam15870
ElonginA binding-protein 1; This domain family is found in eukaryotes, and is typically ...
 767-925 5.52e-86

ElonginA binding-protein 1; This domain family is found in eukaryotes, and is typically between 144 and 167 amino acids in length.


:

Pssm-ID: 464914  Cd Length: 163  Bit Score: 276.94  E-value: 5.52e-86
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566445  767 KPIIPKEFGGKVPTVIRQRYLNLFIEECLKFCTSNQEAIEKALNEEKVAYDRSPSKNIYLNVAVNTLKKLRGLAPSAVPG 846
Cdd:pfam15870    1 RPVIPTEFGSKVPTNIRQRYLNLFIDECLKICTSEQEAFERALEEEKAVYDRCSSKNIYLNVAVNTLKKLRKEVPSQSSA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566445  847 LSKT----SGRRVVSHEVVLGGRLAAKTSFSLSRPSSPRVEDLKGAALYSRLREYLLTQDQLKENGYPFPHPERPGGAII 922
Cdd:pfam15870   81 VTKSsaisSNNKVVSHEAVLGGKLAAKTSFSINRNSKSIEEDLKGATLYRMLKEYLLTEEQLKENGYPRPHPDKPGRAVL 160


                   ...
gi 2462566445  923 FTA 925
Cdd:pfam15870  161 FTA 163
REX1_like cd06145
DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins; This ...
 1035-1168 1.29e-67

DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins; This subfamily is composed of RNA exonuclease 1 (REX1 or Rex1p), REX3 (or Rex3p), and similar eukaryotic proteins. In yeast, REX1 and REX3 are required for 5S rRNA and MRP (mitochondrial RNA processing) RNA maturation, respectively. They are DEDDh-type DnaQ-like 3'-5' exonucleases containing three conserved sequence motifs termed ExoI, ExoII and ExoIII, with a specific Hx(4)D conserved pattern at ExoIII. These motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis. REX1 is the major exonuclease responsible for pre-tRNA trail trimming and may also be involved in nuclear CCA turnover. REX proteins function in the processing and maturation of many RNA species, similar to the function of Escherichia coli RNase T.


:

Pssm-ID: 99848  Cd Length: 150  Bit Score: 224.29  E-value: 1.29e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566445 1035 YALDCEMSYTTYGLELTRVTVVDTDVHVVYDTFVKPDNEIVDYNTRFSGVTEADLADTSVTLRDVQAVLLSMFSADTILI 1114
Cdd:cd06145      1 FALDCEMCYTTDGLELTRVTVVDENGKVVLDELVKPDGEIVDYNTRFSGITEEMLENVTTTLEDVQKKLLSLISPDTILV 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2462566445 1115 GHSLESDLLALKVIHSTVVDTSVLFPHRLGLPYKRSLRNLMADYLRQIIQDNGE 1168
Cdd:cd06145     81 GHSLENDLKALKLIHPRVIDTAILFPHPRGPPYKPSLKNLAKKYLGRDIQQGEG 134
PTZ00449 super family cl33186
104 kDa microneme/rhoptry antigen; Provisional
 365-653 1.28e-04

104 kDa microneme/rhoptry antigen; Provisional


The actual alignment was detected with superfamily member PTZ00449:

Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 46.61  E-value: 1.28e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566445  365 KDKGRGRPVEKPRADKKGPQASSPrrkaERPEGTKKKPSSATPVATSGKGRPDRPARRPSPTsgdsRPAAGRGPPRPLQL 444
Cdd:PTZ00449   583 KDPKHPKDPEEPKKPKRPRSAQRP----TRPKSPKLPELLDIPKSPKRPESPKSPKRPPPPQ----RPSSPERPEGPKII 654

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566445  445 PDRKSTKAPSGKLVERKARSLDEGASQDAPKLKKRALSHADLFGDES---EDEAAGPGVPSVWPSALPSLSSDSDSDSDS 521
Cdd:PTZ00449   655 KSPKPPKSPKPPFDPKFKEKFYDDYLDAAAKSKETKTTVVLDESFESilkETLPETPGTPFTTPRPLPPKLPRDEEFPFE 734

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566445  522 SLGFPEAQGP-------PKRLKASPPPSPAPSSSSSSSSSTSSAGADVDYSALEKEV-----------------DFDSDP 577
Cdd:PTZ00449   735 PIGDPDAEQPddiefftPPEEERTFFHETPADTPLPDILAEEFKEEDIHAETGEPDEamkrpdspsehedkppgDHPSLP 814

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566445  578 ME----ECLRIfneSTSVKTEDRGRLARQPPKE--EKSEEKGLSGLTTL-----FPGQKRRI-------------SHLSK 633
Cdd:PTZ00449   815 KKrhrlDGLAL---STTDLESDAGRIAKDASGKivKLKRSKSFDDLTTVeeaeeMGAEARKIvvdddgteaddedTHPPE 891

                          330       340
                   ....*....|....*....|
gi 2462566445  634 QGQEVEPPRRGPAVPPARPP 653
Cdd:PTZ00449   892 EKHKSEVRRRRPPKKPSKPK 911
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 1172-1332 2.10e-04

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.08  E-value: 2.10e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566445 1172 LPWGRPCAGAGCSPHLPRSGWAqlqrgrrrlhAPGdleGSRRRQDQAMTPARLPPASPAVPLVLSPMPLPKQcNKSPVTR 1251
Cdd:PHA03247  2835 QPTAPPPPPGPPPPSLPLGGSV----------APG---GDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSR-STESFAL 2900

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566445 1252 PPGRGSPEQRDELAARERPAQPTPAHVLPHPSAGPHPLPPSPLASLETAAdgdqdrARPHPARSPSCPSCQALPPGWWPA 1331
Cdd:PHA03247  2901 PPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPA------GAGEPSGAVPQPWLGALVPGRVAV 2974


                   .
gi 2462566445 1332 P 1332
Cdd:PHA03247  2975 P 2975
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 80-446 1.49e-03

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.39  E-value: 1.49e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566445   80 TTREHRSAEAP----ALAPRGPNASPTVGPDEDAFPlafdysPGSHGLLSPdagyQPTPLAAPAEPGSKYSLASLDRGQG 155
Cdd:PHA03247  2583 TSRARRPDAPPqsarPRAPVDDRGDPRGPAPPSPLP------PDTHAPDPP----PPSPSPAANEPDPHPPPTVPPPERP 2652

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566445  156 RGGGGggaleyvPKAVSQPRRHSRPVPSGKYVVDNSRPPTDLEYDPLSNYSArhLSRASSRDERAAKRPRGSRGSEPYTP 235
Cdd:PHA03247  2653 RDDPA-------PGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTS--LADPPPPPPTPEPAPHALVSATPLPP 2723

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566445  236 APKKLCDPFGSCDAR-FSDSEDEAATVPGNE-----PTTASTPKARADPEIKATGQPPSKEglEAEGGGLRETKETA-VQ 308
Cdd:PHA03247  2724 GPAAARQASPALPAApAPPAVPAGPATPGGParparPPTTAGPPAPAPPAAPAAGPPRRLT--RPAVASLSESRESLpSP 2801

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566445  309 CDVGDLQPPPAKPASPAQVQSSQDGGCPKEGKPKKKKTGAPPAPS------CKDGAQGKDKtkdkgRGRPVEKPRADKKG 382
Cdd:PHA03247  2802 WDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPppslplGGSVAPGGDV-----RRRPPSRSPAAKPA 2876

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462566445  383 PQASSPRRKAERPEGTKKKPSSATPVATSGKGRPDRPARRPSPTSGDSRPAAGRGPPRPLQLPD 446
Cdd:PHA03247  2877 APARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQ 2940
 
Name Accession Description Interval E-value
EloA-BP1 pfam15870
ElonginA binding-protein 1; This domain family is found in eukaryotes, and is typically ...
 767-925 5.52e-86

ElonginA binding-protein 1; This domain family is found in eukaryotes, and is typically between 144 and 167 amino acids in length.


Pssm-ID: 464914  Cd Length: 163  Bit Score: 276.94  E-value: 5.52e-86
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566445  767 KPIIPKEFGGKVPTVIRQRYLNLFIEECLKFCTSNQEAIEKALNEEKVAYDRSPSKNIYLNVAVNTLKKLRGLAPSAVPG 846
Cdd:pfam15870    1 RPVIPTEFGSKVPTNIRQRYLNLFIDECLKICTSEQEAFERALEEEKAVYDRCSSKNIYLNVAVNTLKKLRKEVPSQSSA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566445  847 LSKT----SGRRVVSHEVVLGGRLAAKTSFSLSRPSSPRVEDLKGAALYSRLREYLLTQDQLKENGYPFPHPERPGGAII 922
Cdd:pfam15870   81 VTKSsaisSNNKVVSHEAVLGGKLAAKTSFSINRNSKSIEEDLKGATLYRMLKEYLLTEEQLKENGYPRPHPDKPGRAVL 160


                   ...
gi 2462566445  923 FTA 925
Cdd:pfam15870  161 FTA 163
REX1_like cd06145
DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins; This ...
 1035-1168 1.29e-67

DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins; This subfamily is composed of RNA exonuclease 1 (REX1 or Rex1p), REX3 (or Rex3p), and similar eukaryotic proteins. In yeast, REX1 and REX3 are required for 5S rRNA and MRP (mitochondrial RNA processing) RNA maturation, respectively. They are DEDDh-type DnaQ-like 3'-5' exonucleases containing three conserved sequence motifs termed ExoI, ExoII and ExoIII, with a specific Hx(4)D conserved pattern at ExoIII. These motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis. REX1 is the major exonuclease responsible for pre-tRNA trail trimming and may also be involved in nuclear CCA turnover. REX proteins function in the processing and maturation of many RNA species, similar to the function of Escherichia coli RNase T.


Pssm-ID: 99848  Cd Length: 150  Bit Score: 224.29  E-value: 1.29e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566445 1035 YALDCEMSYTTYGLELTRVTVVDTDVHVVYDTFVKPDNEIVDYNTRFSGVTEADLADTSVTLRDVQAVLLSMFSADTILI 1114
Cdd:cd06145      1 FALDCEMCYTTDGLELTRVTVVDENGKVVLDELVKPDGEIVDYNTRFSGITEEMLENVTTTLEDVQKKLLSLISPDTILV 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2462566445 1115 GHSLESDLLALKVIHSTVVDTSVLFPHRLGLPYKRSLRNLMADYLRQIIQDNGE 1168
Cdd:cd06145     81 GHSLENDLKALKLIHPRVIDTAILFPHPRGPPYKPSLKNLAKKYLGRDIQQGEG 134
EXOIII smart00479
exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other ...
 1034-1164 3.38e-23

exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other exonucleases;


Pssm-ID: 214685 [Multi-domain]  Cd Length: 169  Bit Score: 97.76  E-value: 3.38e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566445  1034 IYALDCEMSYTTYG----LELTRVTVVDTDVHVVYDTFVKPDNEIVDYNTRFSGVTEADLADTSvTLRDVQAVLLSMFSA 1109
Cdd:smart00479    2 LVVIDCETTGLDPGkdeiIEIAAVDVDGGEIIEVFDTYVKPDRPITDYATEIHGITPEMLDDAP-TFEEVLEELLEFLRG 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462566445  1110 DTILIGHSLESDLLALKVIH----------STVVDTSVLFPHRLGLPYKRSLRNLMADYLRQIIQ 1164
Cdd:smart00479   81 RILVAGNSAHFDLRFLKLEHprlgikqppkLPVIDTLKLARATNPGLPKYSLKKLAKRLLLEVIQ 145
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 365-653 1.28e-04

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 46.61  E-value: 1.28e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566445  365 KDKGRGRPVEKPRADKKGPQASSPrrkaERPEGTKKKPSSATPVATSGKGRPDRPARRPSPTsgdsRPAAGRGPPRPLQL 444
Cdd:PTZ00449   583 KDPKHPKDPEEPKKPKRPRSAQRP----TRPKSPKLPELLDIPKSPKRPESPKSPKRPPPPQ----RPSSPERPEGPKII 654

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566445  445 PDRKSTKAPSGKLVERKARSLDEGASQDAPKLKKRALSHADLFGDES---EDEAAGPGVPSVWPSALPSLSSDSDSDSDS 521
Cdd:PTZ00449   655 KSPKPPKSPKPPFDPKFKEKFYDDYLDAAAKSKETKTTVVLDESFESilkETLPETPGTPFTTPRPLPPKLPRDEEFPFE 734

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566445  522 SLGFPEAQGP-------PKRLKASPPPSPAPSSSSSSSSSTSSAGADVDYSALEKEV-----------------DFDSDP 577
Cdd:PTZ00449   735 PIGDPDAEQPddiefftPPEEERTFFHETPADTPLPDILAEEFKEEDIHAETGEPDEamkrpdspsehedkppgDHPSLP 814

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566445  578 ME----ECLRIfneSTSVKTEDRGRLARQPPKE--EKSEEKGLSGLTTL-----FPGQKRRI-------------SHLSK 633
Cdd:PTZ00449   815 KKrhrlDGLAL---STTDLESDAGRIAKDASGKivKLKRSKSFDDLTTVeeaeeMGAEARKIvvdddgteaddedTHPPE 891

                          330       340
                   ....*....|....*....|
gi 2462566445  634 QGQEVEPPRRGPAVPPARPP 653
Cdd:PTZ00449   892 EKHKSEVRRRRPPKKPSKPK 911
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1172-1332 2.10e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.08  E-value: 2.10e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566445 1172 LPWGRPCAGAGCSPHLPRSGWAqlqrgrrrlhAPGdleGSRRRQDQAMTPARLPPASPAVPLVLSPMPLPKQcNKSPVTR 1251
Cdd:PHA03247  2835 QPTAPPPPPGPPPPSLPLGGSV----------APG---GDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSR-STESFAL 2900

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566445 1252 PPGRGSPEQRDELAARERPAQPTPAHVLPHPSAGPHPLPPSPLASLETAAdgdqdrARPHPARSPSCPSCQALPPGWWPA 1331
Cdd:PHA03247  2901 PPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPA------GAGEPSGAVPQPWLGALVPGRVAV 2974


                   .
gi 2462566445 1332 P 1332
Cdd:PHA03247  2975 P 2975
PHA03247 PHA03247
large tegument protein UL36; Provisional
 80-446 1.49e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.39  E-value: 1.49e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566445   80 TTREHRSAEAP----ALAPRGPNASPTVGPDEDAFPlafdysPGSHGLLSPdagyQPTPLAAPAEPGSKYSLASLDRGQG 155
Cdd:PHA03247  2583 TSRARRPDAPPqsarPRAPVDDRGDPRGPAPPSPLP------PDTHAPDPP----PPSPSPAANEPDPHPPPTVPPPERP 2652

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566445  156 RGGGGggaleyvPKAVSQPRRHSRPVPSGKYVVDNSRPPTDLEYDPLSNYSArhLSRASSRDERAAKRPRGSRGSEPYTP 235
Cdd:PHA03247  2653 RDDPA-------PGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTS--LADPPPPPPTPEPAPHALVSATPLPP 2723

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566445  236 APKKLCDPFGSCDAR-FSDSEDEAATVPGNE-----PTTASTPKARADPEIKATGQPPSKEglEAEGGGLRETKETA-VQ 308
Cdd:PHA03247  2724 GPAAARQASPALPAApAPPAVPAGPATPGGParparPPTTAGPPAPAPPAAPAAGPPRRLT--RPAVASLSESRESLpSP 2801

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566445  309 CDVGDLQPPPAKPASPAQVQSSQDGGCPKEGKPKKKKTGAPPAPS------CKDGAQGKDKtkdkgRGRPVEKPRADKKG 382
Cdd:PHA03247  2802 WDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPppslplGGSVAPGGDV-----RRRPPSRSPAAKPA 2876

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462566445  383 PQASSPRRKAERPEGTKKKPSSATPVATSGKGRPDRPARRPSPTSGDSRPAAGRGPPRPLQLPD 446
Cdd:PHA03247  2877 APARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQ 2940
 
Name Accession Description Interval E-value
EloA-BP1 pfam15870
ElonginA binding-protein 1; This domain family is found in eukaryotes, and is typically ...
 767-925 5.52e-86

ElonginA binding-protein 1; This domain family is found in eukaryotes, and is typically between 144 and 167 amino acids in length.


Pssm-ID: 464914  Cd Length: 163  Bit Score: 276.94  E-value: 5.52e-86
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566445  767 KPIIPKEFGGKVPTVIRQRYLNLFIEECLKFCTSNQEAIEKALNEEKVAYDRSPSKNIYLNVAVNTLKKLRGLAPSAVPG 846
Cdd:pfam15870    1 RPVIPTEFGSKVPTNIRQRYLNLFIDECLKICTSEQEAFERALEEEKAVYDRCSSKNIYLNVAVNTLKKLRKEVPSQSSA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566445  847 LSKT----SGRRVVSHEVVLGGRLAAKTSFSLSRPSSPRVEDLKGAALYSRLREYLLTQDQLKENGYPFPHPERPGGAII 922
Cdd:pfam15870   81 VTKSsaisSNNKVVSHEAVLGGKLAAKTSFSINRNSKSIEEDLKGATLYRMLKEYLLTEEQLKENGYPRPHPDKPGRAVL 160


                   ...
gi 2462566445  923 FTA 925
Cdd:pfam15870  161 FTA 163
REX1_like cd06145
DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins; This ...
 1035-1168 1.29e-67

DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins; This subfamily is composed of RNA exonuclease 1 (REX1 or Rex1p), REX3 (or Rex3p), and similar eukaryotic proteins. In yeast, REX1 and REX3 are required for 5S rRNA and MRP (mitochondrial RNA processing) RNA maturation, respectively. They are DEDDh-type DnaQ-like 3'-5' exonucleases containing three conserved sequence motifs termed ExoI, ExoII and ExoIII, with a specific Hx(4)D conserved pattern at ExoIII. These motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis. REX1 is the major exonuclease responsible for pre-tRNA trail trimming and may also be involved in nuclear CCA turnover. REX proteins function in the processing and maturation of many RNA species, similar to the function of Escherichia coli RNase T.


Pssm-ID: 99848  Cd Length: 150  Bit Score: 224.29  E-value: 1.29e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566445 1035 YALDCEMSYTTYGLELTRVTVVDTDVHVVYDTFVKPDNEIVDYNTRFSGVTEADLADTSVTLRDVQAVLLSMFSADTILI 1114
Cdd:cd06145      1 FALDCEMCYTTDGLELTRVTVVDENGKVVLDELVKPDGEIVDYNTRFSGITEEMLENVTTTLEDVQKKLLSLISPDTILV 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2462566445 1115 GHSLESDLLALKVIHSTVVDTSVLFPHRLGLPYKRSLRNLMADYLRQIIQDNGE 1168
Cdd:cd06145     81 GHSLENDLKALKLIHPRVIDTAILFPHPRGPPYKPSLKNLAKKYLGRDIQQGEG 134
DEDDh_RNase cd06137
DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonucleases PAN2, RNA exonuclease (REX) ...
 1035-1168 4.00e-33

DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonucleases PAN2, RNA exonuclease (REX)-1,-3, and -4, ISG20, and similar proteins; This group is composed of eukaryotic exoribonucleases that include PAN2, RNA exonuclease 1 (REX1 or Rex1p), REX3 (Rex3p), REX4 (or Rex4p), ISG20, and similar proteins. They are DEDDh-type DnaQ-like 3'-5' exonucleases containing three conserved sequence motifs termed ExoI, ExoII and ExoIII, with a specific Hx(4)D conserved pattern at ExoIII. These motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis. PAN2 is the catalytic subunit of poly(A) nuclease (PAN), a Pab1p-dependent 3'-5' exoribonuclease which plays an important role in the posttranscriptional maturation of pre-mRNAs. REX proteins are required for the processing and maturation of many RNA species, and ISG20 is an interferon-induced antiviral exonuclease with a strong preference for single-stranded RNA.


Pssm-ID: 99840  Cd Length: 161  Bit Score: 125.86  E-value: 4.00e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566445 1035 YALDCEMSYTTYGL-ELTRVTV-VDTDVHVVYDTFVKPDNEIVDYNTRFSGVTEADLAD---TSVTLR--DVQAVLLSMF 1107
Cdd:cd06137      1 VALDCEMVGLADGDsEVVRISAvDVLTGEVLIDSLVRPSVRVTDWRTRFSGVTPADLEEaakAGKTIFgwEAARAALWKF 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462566445 1108 S-ADTILIGHSLESDLLALKVIHSTVVDTSVLFPHRLGLPY---KRSLRNLMADYLRQIIQDNGE 1168
Cdd:cd06137     81 IdPDTILVGHSLQNDLDALRMIHTRVVDTAILTREAVKGPLakrQWSLRTLCRDFLGLKIQGGGE 145
EXOIII smart00479
exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other ...
 1034-1164 3.38e-23

exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other exonucleases;


Pssm-ID: 214685 [Multi-domain]  Cd Length: 169  Bit Score: 97.76  E-value: 3.38e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566445  1034 IYALDCEMSYTTYG----LELTRVTVVDTDVHVVYDTFVKPDNEIVDYNTRFSGVTEADLADTSvTLRDVQAVLLSMFSA 1109
Cdd:smart00479    2 LVVIDCETTGLDPGkdeiIEIAAVDVDGGEIIEVFDTYVKPDRPITDYATEIHGITPEMLDDAP-TFEEVLEELLEFLRG 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462566445  1110 DTILIGHSLESDLLALKVIH----------STVVDTSVLFPHRLGLPYKRSLRNLMADYLRQIIQ 1164
Cdd:smart00479   81 RILVAGNSAHFDLRFLKLEHprlgikqppkLPVIDTLKLARATNPGLPKYSLKKLAKRLLLEVIQ 145
REX4_like cd06144
DEDDh 3'-5' exonuclease domain of RNA exonuclease 4, XPMC2, Interferon Stimulated Gene product ...
 1064-1165 3.12e-18

DEDDh 3'-5' exonuclease domain of RNA exonuclease 4, XPMC2, Interferon Stimulated Gene product of 20 kDa, and similar proteins; This subfamily is composed of RNA exonuclease 4 (REX4 or Rex4p), XPMC2, Interferon (IFN) Stimulated Gene product of 20 kDa (ISG20), and similar proteins. REX4 is involved in pre-rRNA processing. It controls the ratio between the two forms of 5.8S rRNA in yeast. XPMC2 is a Xenopus gene which was identified through its ability to correct a mitotic defect in fission yeast. The human homolog of XPMC2 (hPMC2) may be involved in angiotensin II-induced adrenal cell cycle progression and cell proliferation. ISG20 is an IFN-induced antiviral exonuclease with a strong preference for single-stranded RNA and minor activity towards single-stranded DNA. These proteins are DEDDh-type DnaQ-like 3'-5' exonucleases containing three conserved sequence motifs termed ExoI, ExoII and ExoIII, with a specific Hx(4)D conserved pattern at ExoIII. These motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis. REX proteins function in the processing and maturation of many RNA species, similar to the function of Escherchia coli RNase T.


Pssm-ID: 99847  Cd Length: 152  Bit Score: 82.95  E-value: 3.12e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566445 1064 YDTFVKPDNEIVDYNTRFSGVTEADLADtSVTLRDVQAVLLSMFsADTILIGHSLESDLLALKVIHST--VVDTSVLFP- 1140
Cdd:cd06144     33 YDTYVKPQEPVTDYRTAVSGIRPEHLKD-APDFEEVQKKVAELL-KGRILVGHALKNDLKVLKLDHPKklIRDTSKYKPl 110

                           90       100
                   ....*....|....*....|....*
gi 2462566445 1141 HRLGLPYKRSLRNLMADYLRQIIQD 1165
Cdd:cd06144    111 RKTAKGKSPSLKKLAKQLLGLDIQE 135
ISG20 cd06149
DEDDh 3'-5' exonuclease domain of Interferon Stimulated Gene product of 20 kDa, and similar ...
 1036-1164 4.36e-12

DEDDh 3'-5' exonuclease domain of Interferon Stimulated Gene product of 20 kDa, and similar proteins; Interferon (IFN) Stimulated Gene product of 20 kDa (ISG20) is an IFN-induced antiviral exonuclease with a strong preference for single-stranded RNA and minor activity towards single-stranded DNA. It was also independently identified by its response to estrogen and was called HEM45 (human estrogen regulated transcript). ISG20 is a DEDDh-type DnaQ-like 3'-5' exonuclease containing three conserved sequence motifs termed ExoI, ExoII and ExoIII with a specific Hx(4)D conserved pattern at ExoIII. These motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis. ISG20 may be a major effector of innate immunity against pathogens including viruses, bacteria, and parasites. It is located in promyelocytic leukemia (PML) nuclear bodies, sites for oncogenic DNA viral transcription and replication. It may carry out its function by degrading viral RNAs as part of the IFN-regulated antiviral response.


Pssm-ID: 99852  Cd Length: 157  Bit Score: 65.54  E-value: 4.36e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566445 1036 ALDCEMSYTTYGL---ELTRVTVVDTDVHVVYDTFVKPDNEIVDYNTRFSGVTEADLADtSVTLRDVQAVLLSMFSAdTI 1112
Cdd:cd06149      2 AIDCEMVGTGPGGresELARCSIVNYHGDVLYDKYIRPEGPVTDYRTRWSGIRRQHLVN-ATPFAVAQKEILKILKG-KV 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462566445 1113 LIGHSLESDLLALKVIHS--TVVDTS--VLFPHRLGLPYKR--SLRNLMADYLRQIIQ 1164
Cdd:cd06149     80 VVGHAIHNDFKALKYFHPkhMTRDTStiPLLNRKAGFPENCrvSLKVLAKRLLHRDIQ 137
PAN2_exo cd06143
DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonuclease PAN2; PAN2 is the catalytic ...
 1065-1167 1.87e-10

DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonuclease PAN2; PAN2 is the catalytic subunit of poly(A) nuclease (PAN), a Pab1p-dependent 3'-5' exoribonuclease which plays an important role in the posttranscriptional maturation of pre-mRNAs. PAN catalyzes the deadenylation of poly(A) tails, which are initially synthesized to default lengths of 70 to 90, to mRNA-specific lengths of 55 to 71. Pab1p and PAN also play a role in the export and decay of mRNA. PAN2 contains a DEDDh-type DnaQ-like 3'-5' exonuclease domain with three conserved sequence motifs termed ExoI, ExoII and ExoIII, with a specific Hx(4)D conserved pattern at ExoIII. These motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis.


Pssm-ID: 99846  Cd Length: 174  Bit Score: 61.09  E-value: 1.87e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566445 1065 DTFVKPDNEIVDYNTRFSGVTEADL-ADTS----VTLRDVQAVLLSMFSADTILIGHSLESDL--LALKVIHSTVVDTSV 1137
Cdd:cd06143     52 DDYISTTEPVVDYLTRFSGIKPGDLdPKTSsknlTTLKSAYLKLRLLVDLGCIFVGHGLAKDFrvINIQVPKEQVIDTVE 131

                           90       100       110
                   ....*....|....*....|....*....|
gi 2462566445 1138 LFphRLGLPYKRSLRNLMADYLRQIIQDNG 1167
Cdd:cd06143    132 LF--HLPGQRKLSLRFLAWYLLGEKIQSET 159
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 365-653 1.28e-04

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 46.61  E-value: 1.28e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566445  365 KDKGRGRPVEKPRADKKGPQASSPrrkaERPEGTKKKPSSATPVATSGKGRPDRPARRPSPTsgdsRPAAGRGPPRPLQL 444
Cdd:PTZ00449   583 KDPKHPKDPEEPKKPKRPRSAQRP----TRPKSPKLPELLDIPKSPKRPESPKSPKRPPPPQ----RPSSPERPEGPKII 654

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566445  445 PDRKSTKAPSGKLVERKARSLDEGASQDAPKLKKRALSHADLFGDES---EDEAAGPGVPSVWPSALPSLSSDSDSDSDS 521
Cdd:PTZ00449   655 KSPKPPKSPKPPFDPKFKEKFYDDYLDAAAKSKETKTTVVLDESFESilkETLPETPGTPFTTPRPLPPKLPRDEEFPFE 734

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566445  522 SLGFPEAQGP-------PKRLKASPPPSPAPSSSSSSSSSTSSAGADVDYSALEKEV-----------------DFDSDP 577
Cdd:PTZ00449   735 PIGDPDAEQPddiefftPPEEERTFFHETPADTPLPDILAEEFKEEDIHAETGEPDEamkrpdspsehedkppgDHPSLP 814

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566445  578 ME----ECLRIfneSTSVKTEDRGRLARQPPKE--EKSEEKGLSGLTTL-----FPGQKRRI-------------SHLSK 633
Cdd:PTZ00449   815 KKrhrlDGLAL---STTDLESDAGRIAKDASGKivKLKRSKSFDDLTTVeeaeeMGAEARKIvvdddgteaddedTHPPE 891

                          330       340
                   ....*....|....*....|
gi 2462566445  634 QGQEVEPPRRGPAVPPARPP 653
Cdd:PTZ00449   892 EKHKSEVRRRRPPKKPSKPK 911
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1172-1332 2.10e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.08  E-value: 2.10e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566445 1172 LPWGRPCAGAGCSPHLPRSGWAqlqrgrrrlhAPGdleGSRRRQDQAMTPARLPPASPAVPLVLSPMPLPKQcNKSPVTR 1251
Cdd:PHA03247  2835 QPTAPPPPPGPPPPSLPLGGSV----------APG---GDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSR-STESFAL 2900

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566445 1252 PPGRGSPEQRDELAARERPAQPTPAHVLPHPSAGPHPLPPSPLASLETAAdgdqdrARPHPARSPSCPSCQALPPGWWPA 1331
Cdd:PHA03247  2901 PPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPA------GAGEPSGAVPQPWLGALVPGRVAV 2974


                   .
gi 2462566445 1332 P 1332
Cdd:PHA03247  2975 P 2975
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1184-1334 2.46e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.70  E-value: 2.46e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566445 1184 SPHLPRSGWAQLQRGRRRLHAP--GDLEGSRRRQDQAMTPA-RLPPASPAVPLVLSPMPLPKQCNK---SPVTRPPGRG- 1256
Cdd:PHA03247  2669 RLGRAAQASSPPQRPRRRAARPtvGSLTSLADPPPPPPTPEpAPHALVSATPLPPGPAAARQASPAlpaAPAPPAVPAGp 2748

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566445 1257 ----SPEQRDELAARERPAQPTPAHVlphPSAGPHP-LPPSPLASLETAADGDQDRARPHPARSPSCPSCQALPPGWWPA 1331
Cdd:PHA03247  2749 atpgGPARPARPPTTAGPPAPAPPAA---PAAGPPRrLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPA 2825


                   ...
gi 2462566445 1332 PLL 1334
Cdd:PHA03247  2826 GPL 2828
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
1204-1332 8.22e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 43.71  E-value: 8.22e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566445 1204 APGDLEGSRRRQDQAMTPARLPPASPAVPLVLSPMPLPkqcnksPVTRPPGRGSPEQRDELAARERPAQPTPAHVLPHPS 1283
Cdd:PRK12323   380 APVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAAR------AVAAAPARRSPAPEALAAARQASARGPGGAPAPAPA 453

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462566445 1284 AGPHPLP--PSPLASLETAADGDQDRARPHPARSPSCPSCQALPPgWWPAP 1332
Cdd:PRK12323   454 PAAAPAAaaRPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPP-WEELP 503
PHA03247 PHA03247
large tegument protein UL36; Provisional
 80-446 1.49e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.39  E-value: 1.49e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566445   80 TTREHRSAEAP----ALAPRGPNASPTVGPDEDAFPlafdysPGSHGLLSPdagyQPTPLAAPAEPGSKYSLASLDRGQG 155
Cdd:PHA03247  2583 TSRARRPDAPPqsarPRAPVDDRGDPRGPAPPSPLP------PDTHAPDPP----PPSPSPAANEPDPHPPPTVPPPERP 2652

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566445  156 RGGGGggaleyvPKAVSQPRRHSRPVPSGKYVVDNSRPPTDLEYDPLSNYSArhLSRASSRDERAAKRPRGSRGSEPYTP 235
Cdd:PHA03247  2653 RDDPA-------PGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTS--LADPPPPPPTPEPAPHALVSATPLPP 2723

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566445  236 APKKLCDPFGSCDAR-FSDSEDEAATVPGNE-----PTTASTPKARADPEIKATGQPPSKEglEAEGGGLRETKETA-VQ 308
Cdd:PHA03247  2724 GPAAARQASPALPAApAPPAVPAGPATPGGParparPPTTAGPPAPAPPAAPAAGPPRRLT--RPAVASLSESRESLpSP 2801

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566445  309 CDVGDLQPPPAKPASPAQVQSSQDGGCPKEGKPKKKKTGAPPAPS------CKDGAQGKDKtkdkgRGRPVEKPRADKKG 382
Cdd:PHA03247  2802 WDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPppslplGGSVAPGGDV-----RRRPPSRSPAAKPA 2876

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462566445  383 PQASSPRRKAERPEGTKKKPSSATPVATSGKGRPDRPARRPSPTSGDSRPAAGRGPPRPLQLPD 446
Cdd:PHA03247  2877 APARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQ 2940
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 87-442 1.90e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 42.85  E-value: 1.90e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566445   87 AEAPALAPRGPNASPTVGPDEDAFPLAFDYSPGSHglLSPDAGYQPTPLAAPAEPGSKYSLASLDRGQGRGGGGGGALey 166
Cdd:PHA03307    99 SPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPD--LSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAAL-- 174

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566445  167 vpkAVSQPRRHSRPVPSGKYVVDNSRPPTDLEYDPlsnySARHLSRASSRDERAAKRPRGSRGsepytPAPKKLCDPFGS 246
Cdd:PHA03307   175 ---PLSSPEETARAPSSPPAEPPPSTPPAAASPRP----PRRSSPISASASSPAPAPGRSAAD-----DAGASSSDSSSS 242

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566445  247 CDARFSDSEDEAATVPGNEPTTASTPKARADPEIkatgQPPSKEGLEAEGGGLRETKETAVQCDVGDLQPPPAKPASPAQ 326
Cdd:PHA03307   243 ESSGCGWGPENECPLPRPAPITLPTRIWEASGWN----GPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSS 318

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566445  327 VQSSQDG-GCPKEGKPKKKKTGAPPAPSCKDGAQGKDktkDKGRGRPVEKPRADKKGPQASSPRRKAERPEGTKKKPSSA 405
Cdd:PHA03307   319 SSSRESSsSSTSSSSESSRGAAVSPGPSPSRSPSPSR---PPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVA 395

                          330       340       350
                   ....*....|....*....|....*....|....*...
gi 2462566445  406 TPVATSGK-GRPDRPARRPSPTSGDSRPAAGRGPPRPL 442
Cdd:PHA03307   396 GRARRRDAtGRFPAGRPRPSPLDAGAASGAFYARYPLL 433
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 1217-1327 2.47e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 42.01  E-value: 2.47e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566445 1217 QAMTPARLPPASPAVPLVLSPMPlPKQcnKSPVTRPPGRGSPEQRDELAAR----ERPAQPTPAHVLPHPsagPHPLPPS 1292
Cdd:PRK14951   385 EAAAPAAAPVAQAAAAPAPAAAP-AAA--ASAPAAPPAAAPPAPVAAPAAAapaaAPAAAPAAVALAPAP---PAQAAPE 458

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 2462566445 1293 PLASLETAADG-DQDRARPHPARSPSCPSCQALPPG 1327
Cdd:PRK14951   459 TVAIPVRVAPEpAVASAAPAPAAAPAAARLTPTEEG 494
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1196-1332 2.82e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.23  E-value: 2.82e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566445 1196 QRGRRRLHAPGD---LEGSRRR---------QDQAMTPARLPPASPAVPLVLSPMPLPKQCNKSPVTRPPGRGSPEQRDE 1263
Cdd:PHA03247  2665 RRARRLGRAAQAsspPQRPRRRaarptvgslTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAV 2744

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462566445 1264 LAARERPAQPTPAHVLPHPSAGPHPLPPSplasletAADGDQDRARPHPARSPSCPSCQALPPGWWPAP 1332
Cdd:PHA03247  2745 PAGPATPGGPARPARPPTTAGPPAPAPPA-------APAAGPPRRLTRPAVASLSESRESLPSPWDPAD 2806
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
1176-1332 4.54e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.40  E-value: 4.54e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566445 1176 RPCAGAGCSPHLPRSGWAQLQRGRRRLHAPGDLEGSRRRQDQAMTPARLPPASPAVplvlSPMPLPKQCNKSPVTRPPGR 1255
Cdd:PRK12323   401 APPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAPAA----APAAAARPAAAGPRPVAAAA 476

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566445 1256 GSPEQRDELAARERPA--QPTPAHVLPHPSAGPHPLPPSP--------LASLETAADGDQDRARPHPARSPSCPSCQALP 1325
Cdd:PRK12323   477 AAAPARAAPAAAPAPAddDPPPWEELPPEFASPAPAQPDAapagwvaeSIPDPATADPDDAFETLAPAPAAAPAPRAAAA 556


                   ....*..
gi 2462566445 1326 PGWWPAP 1332
Cdd:PRK12323   557 TEPVVAP 563
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1222-1346 5.22e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 5.22e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566445 1222 ARLPPASPAVPLVLSPMPLPKQCNKSPVTRPPGRGSPEQRDELAARERPAQPTPAHVLPHPSAGPHPLPPSPlasletaa 1301
Cdd:PHA03247  2863 RRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPP-------- 2934

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 2462566445 1302 dgdqDRARPHPARSPSC-PSCQALPPGWWPAPLLLTWVAGR-ACPRF 1346
Cdd:PHA03247  2935 ----PPPRPQPPLAPTTdPAGAGEPSGAVPQPWLGALVPGRvAVPRF 2977
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1216-1326 5.44e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 5.44e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566445 1216 DQAMTPARLPPASPAVPLVLSPMPLPKQCNKSPVTRPPGrgSPEQRDELAARERPAQPTPAHVLPHPSAGPHPLPPSPLA 1295
Cdd:PHA03247  2774 APAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVL--APAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLP 2851

                           90       100       110
                   ....*....|....*....|....*....|.
gi 2462566445 1296 SLETAADGDQDRARPHPARSPSCPSCQALPP 1326
Cdd:PHA03247  2852 LGGSVAPGGDVRRRPPSRSPAAKPAAPARPP 2882
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1222-1332 9.17e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 9.17e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566445 1222 ARLPPASPAVPLVLSPMPLPKQCNKSPVTRPPG-------RGSPEQRDELAARERPAQPTPAHVLPHPSAGPHPLPPSPL 1294
Cdd:PHA03247  2741 PPAVPAGPATPGGPARPARPPTTAGPPAPAPPAapaagppRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPP 2820

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 2462566445 1295 ASLETAADGDQDRARPHPARSPSCPSCQALPPGWWPAP 1332
Cdd:PHA03247  2821 AASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAP 2858
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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