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Conserved domains on  [gi|2462628241|ref|XP_054182447|]
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highly divergent homeobox isoform X1 [Homo sapiens]

Protein Classification

homeobox domain-containing protein( domain architecture ID 10647767)

homeobox domain-containing protein similar to highly divergent homeobox that may be involved in regulation of transcription by RNA polymerase II

CATH:  1.10.10.60
Gene Ontology:  GO:0006357|GO:0043565|GO:0000978
PubMed:  21557080|26464018|27768937|1357790
SCOP:  4000291

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 439-495 1.43e-04

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


:

Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 40.30  E-value: 1.43e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462628241 439 RTQFSDRDLATLKKYWDNGMTslgsVCREKIEAVATELNVDCEIVRTWIGNRRRKYR 495
Cdd:cd00086     4 RTRFTPEQLEELEKEFEKNPY----PSREEREELAKELGLTERQVKIWFQNRRAKLK 56
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 4-59 6.20e-04

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


:

Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 38.39  E-value: 6.20e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462628241    4 RSVFTVEQQRILQRYYEngmtnqsKNCF---QLILQCAQETKLDFSVVRTWVGNKRRKM 59
Cdd:smart00389   5 RTSFTPEQLEELEKEFQ-------KNPYpsrEEREELAKKLGLSERQVKVWFQNRRAKW 56
 
Name Accession Description Interval E-value
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 439-495 1.43e-04

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 40.30  E-value: 1.43e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462628241 439 RTQFSDRDLATLKKYWDNGMTslgsVCREKIEAVATELNVDCEIVRTWIGNRRRKYR 495
Cdd:cd00086     4 RTRFTPEQLEELEKEFEKNPY----PSREEREELAKELGLTERQVKIWFQNRRAKLK 56
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 4-59 6.20e-04

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 38.39  E-value: 6.20e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462628241    4 RSVFTVEQQRILQRYYEngmtnqsKNCF---QLILQCAQETKLDFSVVRTWVGNKRRKM 59
Cdd:smart00389   5 RTSFTPEQLEELEKEFQ-------KNPYpsrEEREELAKKLGLSERQVKVWFQNRRAKW 56
Homeodomain pfam00046
Homeodomain;
439-495 6.94e-04

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 38.25  E-value: 6.94e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462628241 439 RTQFSDRDLATLKKYWDNGMTslgsVCREKIEAVATELNVDCEIVRTWIGNRRRKYR 495
Cdd:pfam00046   4 RTTFTPEQLEELEKEFQENPY----PSAEEREELAAQLGLTERQVKVWFQNRRAKWK 56
Homeodomain pfam00046
Homeodomain;
4-59 8.54e-04

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 37.86  E-value: 8.54e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462628241   4 RSVFTVEQQRILQRYYENgmtNQSKNCFQlILQCAQETKLDFSVVRTWVGNKRRKM 59
Cdd:pfam00046   4 RTTFTPEQLEELEKEFQE---NPYPSAEE-REELAAQLGLTERQVKVWFQNRRAKW 55
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 439-495 1.85e-03

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 36.84  E-value: 1.85e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462628241  439 RTQFSDRDLATLKKYWDNGMTslgsVCREKIEAVATELNVDCEIVRTWIGNRRRKYR 495
Cdd:smart00389   5 RTSFTPEQLEELEKEFQKNPY----PSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
 
Name Accession Description Interval E-value
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 439-495 1.43e-04

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 40.30  E-value: 1.43e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462628241 439 RTQFSDRDLATLKKYWDNGMTslgsVCREKIEAVATELNVDCEIVRTWIGNRRRKYR 495
Cdd:cd00086     4 RTRFTPEQLEELEKEFEKNPY----PSREEREELAKELGLTERQVKIWFQNRRAKLK 56
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 4-59 6.20e-04

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 38.39  E-value: 6.20e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462628241    4 RSVFTVEQQRILQRYYEngmtnqsKNCF---QLILQCAQETKLDFSVVRTWVGNKRRKM 59
Cdd:smart00389   5 RTSFTPEQLEELEKEFQ-------KNPYpsrEEREELAKKLGLSERQVKVWFQNRRAKW 56
Homeodomain pfam00046
Homeodomain;
439-495 6.94e-04

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 38.25  E-value: 6.94e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462628241 439 RTQFSDRDLATLKKYWDNGMTslgsVCREKIEAVATELNVDCEIVRTWIGNRRRKYR 495
Cdd:pfam00046   4 RTTFTPEQLEELEKEFQENPY----PSAEEREELAAQLGLTERQVKVWFQNRRAKWK 56
Homeodomain pfam00046
Homeodomain;
4-59 8.54e-04

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 37.86  E-value: 8.54e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462628241   4 RSVFTVEQQRILQRYYENgmtNQSKNCFQlILQCAQETKLDFSVVRTWVGNKRRKM 59
Cdd:pfam00046   4 RTTFTPEQLEELEKEFQE---NPYPSAEE-REELAAQLGLTERQVKVWFQNRRAKW 55
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 439-495 1.85e-03

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 36.84  E-value: 1.85e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462628241  439 RTQFSDRDLATLKKYWDNGMTslgsVCREKIEAVATELNVDCEIVRTWIGNRRRKYR 495
Cdd:smart00389   5 RTSFTPEQLEELEKEFQKNPY----PSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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