NCBI Conserved Domain Search

Conserved domains on [gi|2462515956|ref|XP_054195854|]

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histone-lysine N-methyltransferase SETDB1 isoform X3 [Homo sapiens]

Protein Classification

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List of domain hits

Name

Accession

Description

Interval

E-value

SET_SETDB1

cd10517

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...

121-322

5.92e-134

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and similar proteins; SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes.

Pssm-ID: 380915 [Multi-domain] Cd Length: 288 Bit Score: 397.04 E-value: 5.92e-134

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 121 KPFYYILDITYGKEDVPLSCVNEIDTTPPPQVAYSKERIPGKGVFINTGPEFLVGCDCKDGCRDKSKCACHQLTIQATAC 200
Cdd:cd10517     1 KPYYYICDISYGKEGVPIPCVNEIDNSSPPYVEYSKERIPGKGVNINLDPDFLVGCDCTDGCRDKSKCACQQLTIEATAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 201 TPGGQINPNSGYQYKRLEECLPTGVYECNKRCKCDpNMCTNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYA 280
Cdd:cd10517    81 TPGGQINPSAGYQYRRLMEKLPTGVYECNSRCKCD-KRCYNRVVQNGLQVRLQVFKTEKKGWGIRCLDDIPKGSFVCIYA 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 2462515956 281 GKILTDDFADKEGLEMGDEYFANLDHIESVENFKEGYESDAP 322
Cdd:cd10517   160 GQILTEDEANEEGLQYGDEYFAELDYIEVVEKLKEGYESDVE 201

SET super family

cl40432

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, ...

649-738

9.69e-64

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain superfamily corresponds to SET domain-containing lysine methyltransferases, which catalyze site and state-specific methylation of lysine residues in histones that are fundamental in epigenetic regulation of gene activation and silencing in eukaryotic organisms. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains has been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as N-SET and C-SET. C-SET forms an unusual and conserved knot-like structure of probable functional importance. In addition to N-SET and C-SET, an insert region (I-SET) and flanking regions of high structural variability form part of the overall structure. Some family members contain a pre-SET domain, which is found in a number of histone methyltransferases (HMTase), and a post-SET domain, which harbors a zinc-binding site.

The actual alignment was detected with superfamily member cd10517:

Pssm-ID: 394802 [Multi-domain] Cd Length: 288 Bit Score: 214.07 E-value: 9.69e-64

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 649 DGEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKRIRAGTELTWDYNYEVGSVEGKELLCCC 728
Cdd:cd10517   199 DVEEHCYIIDAKSEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASRYIRAGTELTWDYNYEVGSVPGKVLYCYC 278

                          90
                  ....*....|
gi 2462515956 729 GAIECRGRLL 738
Cdd:cd10517   279 GSSNCRGRLL 288

MBD

smart00391

Methyl-CpG binding domain; Methyl-CpG binding domain, also known as the TAM (TTF-IIP5, ARBP, ...

44-119

3.06e-27

Methyl-CpG binding domain; Methyl-CpG binding domain, also known as the TAM (TTF-IIP5, ARBP, MeCP1) domain

Pssm-ID: 128673 Cd Length: 77 Bit Score: 105.15 E-value: 3.06e-27

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462515956   44 KNPLLVPLLYDFRRMTARRRVNR-KMGFHVIYKTPCGLCLRTMQEIERYLFETGCDFLFLEMFCLDPYVLVDRKFQP 119
Cdd:smart00391   1 GDPLRLPLPCGWRRETKQRKSGRsAGKFDVYYISPCGKKLRSKSELARYLHKNGDLSLDLECFDFNATVPVGPKFTP 77

Name

Accession

Description

Interval

E-value

SET_SETDB1

cd10517

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...

121-322

5.92e-134

Pssm-ID: 380915 [Multi-domain] Cd Length: 288 Bit Score: 397.04 E-value: 5.92e-134

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 121 KPFYYILDITYGKEDVPLSCVNEIDTTPPPQVAYSKERIPGKGVFINTGPEFLVGCDCKDGCRDKSKCACHQLTIQATAC 200
Cdd:cd10517     1 KPYYYICDISYGKEGVPIPCVNEIDNSSPPYVEYSKERIPGKGVNINLDPDFLVGCDCTDGCRDKSKCACQQLTIEATAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 201 TPGGQINPNSGYQYKRLEECLPTGVYECNKRCKCDpNMCTNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYA 280
Cdd:cd10517    81 TPGGQINPSAGYQYRRLMEKLPTGVYECNSRCKCD-KRCYNRVVQNGLQVRLQVFKTEKKGWGIRCLDDIPKGSFVCIYA 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 2462515956 281 GKILTDDFADKEGLEMGDEYFANLDHIESVENFKEGYESDAP 322
Cdd:cd10517   160 GQILTEDEANEEGLQYGDEYFAELDYIEVVEKLKEGYESDVE 201

SET_SETDB1

cd10517

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...

649-738

9.69e-64

Pssm-ID: 380915 [Multi-domain] Cd Length: 288 Bit Score: 214.07 E-value: 9.69e-64

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 649 DGEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKRIRAGTELTWDYNYEVGSVEGKELLCCC 728
Cdd:cd10517   199 DVEEHCYIIDAKSEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASRYIRAGTELTWDYNYEVGSVPGKVLYCYC 278

                          90
                  ....*....|
gi 2462515956 729 GAIECRGRLL 738
Cdd:cd10517   279 GSSNCRGRLL 288

MBD

smart00391

Methyl-CpG binding domain; Methyl-CpG binding domain, also known as the TAM (TTF-IIP5, ARBP, ...

44-119

3.06e-27

Methyl-CpG binding domain; Methyl-CpG binding domain, also known as the TAM (TTF-IIP5, ARBP, MeCP1) domain

Pssm-ID: 128673 Cd Length: 77 Bit Score: 105.15 E-value: 3.06e-27

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462515956   44 KNPLLVPLLYDFRRMTARRRVNR-KMGFHVIYKTPCGLCLRTMQEIERYLFETGCDFLFLEMFCLDPYVLVDRKFQP 119
Cdd:smart00391   1 GDPLRLPLPCGWRRETKQRKSGRsAGKFDVYYISPCGKKLRSKSELARYLHKNGDLSLDLECFDFNATVPVGPKFTP 77

PreSET

smart00468

N-terminal to some SET domains; A Cys-rich putative Zn2+-binding domain that occurs N-terminal ...

126-233

3.70e-27

N-terminal to some SET domains; A Cys-rich putative Zn2+-binding domain that occurs N-terminal to some SET domains. Function is unknown. Unpublished.

Pssm-ID: 128744 [Multi-domain] Cd Length: 98 Bit Score: 105.58 E-value: 3.70e-27

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956  126 ILDITYGKEDVPLSCVNEID-TTPPPQVAYSKERIPGKGVFINTGPEFLVGCDCKDGCRDKSKCACHQLTiqatactpGG 204
Cdd:smart00468   1 CLDISNGKENVPVPLVNEVDeDPPPPDFEYISEYIYGQGVPIDRSPSPLVGCSCSGDCSSSNKCECARKN--------GG 72

                           90       100
                   ....*....|....*....|....*....
gi 2462515956  205 QINPNsgyQYKRLEECLPTGVYECNKRCK 233
Cdd:smart00468  73 EFAYE---LNGGLRLKRKPLIYECNSRCS 98

HMT_MBD

cd01395

Methyl-CpG binding domains (MBD) present in putative histone methyltransferases (HMT) such as ...

46-107

3.50e-25

Methyl-CpG binding domains (MBD) present in putative histone methyltransferases (HMT) such as CLLD8 and SETDB1 proteins; CLLD8 contains a MBD, a PreSET and a bifurcated SET domain, suggesting that CLLD8 might be associated with methylation-mediated transcriptional repression. SETDB1 and other proteins in this group have a similar domain architecture. SETDB1 is a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins.

Pssm-ID: 238689 Cd Length: 60 Bit Score: 98.61 E-value: 3.50e-25

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462515956  46 PLLVPLLYDFRRMTARRRVNrKMGFHVIYKTPCGLCLRTMQEIERYLFETgCDFLFLEMFCL 107
Cdd:cd01395     1 PLHTPLLCGFQRMKYRARVG-KVKKHVIYKAPCGRSLRNMSEVHRYLRET-CSFLTVDNFSF 60

MBD

pfam01429

Methyl-CpG binding domain; The Methyl-CpG binding domain (MBD) binds to DNA that contains one ...

41-115

5.33e-23

Methyl-CpG binding domain; The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase.

Pssm-ID: 396147 [Multi-domain] Cd Length: 76 Bit Score: 93.19 E-value: 5.33e-23

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462515956  41 YRGKNPLLVPLLYDFRRMTARRRVNRKMG-FHVIYKTPCGLCLRTMQEIERYLFETGCDFLFLEMFCLDPYVLVDR 115
Cdd:pfam01429   1 IERKREDRLPLPPGWRREERQRKSGSKAGkVDVFYYSPTGKKLRSKSEVARYLEANGGTSPKLEDFSFTVRSEVGR 76

Pre-SET

pfam05033

Pre-SET motif; This protein motif is a zinc binding motif. It contains 9 conserved cysteines ...

129-242

4.02e-21

Pre-SET motif; This protein motif is a zinc binding motif. It contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilising SET domains.

Pssm-ID: 461530 [Multi-domain] Cd Length: 99 Bit Score: 88.63 E-value: 4.02e-21

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 129 ITYGKEDVPLSCVNEID-TTPPPQVAYSKERIPGKGVFINtgpeFLVGCDCKDgCrDKSKCACHQLTiqatactpggQIN 207
Cdd:pfam05033   1 ISKGKENVPIPVVNEVDdEPPPPDFTYITSYIYPKEFLLI----IPQGCDCGD-C-SSEKCSCAQLN----------GGE 64

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2462515956 208 PNSGYQYK-RLEECLPTGVYECNKRCKCDPNmCTNR 242
Cdd:pfam05033  65 FRFPYDKDgLLVPESKPPIYECNPLCGCPPS-CPNR 99

SET

smart00317

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...

653-715

8.14e-19

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues

Pssm-ID: 214614 [Multi-domain] Cd Length: 124 Bit Score: 82.77 E-value: 8.14e-19

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462515956  653 SCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDlrfpWVAFFASKRIRAGTELTWDYNYE 715
Cdd:smart00317  62 SDLCIDARRKGNLARFINHSCEPNCELLFVEVNGDD----RIVIFALRDIKPGEELTIDYGSD 120

SET

pfam00856

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...

647-713

9.65e-16

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.

Pssm-ID: 459965 [Multi-domain] Cd Length: 115 Bit Score: 73.71 E-value: 9.65e-16

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462515956 647 FYDGEESCYIIDAKLE--GNLGRYLNHSCSPNLFVQNVFVDthdlRFPWVAFFASKRIRAGTELTWDYN 713
Cdd:pfam00856  51 FTLDEDSEYCIDARALyyGNWARFINHSCDPNCEVRVVYVN----GGPRIVIFALRDIKPGEELTIDYG 115

SET

COG2940

SET domain-containing protein (function unknown) [General function prediction only];

655-736

3.90e-15

SET domain-containing protein (function unknown) [General function prediction only];

Pssm-ID: 442183 [Multi-domain] Cd Length: 134 Bit Score: 72.69 E-value: 3.90e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 655 YIIDAKLEGNLGRYLNHSCSPNLFVqnvfvdthDLRFPWVAFFASKRIRAGTELTWDYNYEvgsVEGKELLCCCGAieCR 734
Cdd:COG2940    66 GVIDGALGGNPARFINHSCDPNCEA--------DEEDGRIFIVALRDIAAGEELTYDYGLD---YDEEEYPCRCPN--CR 132


                  ..
gi 2462515956 735 GR 736
Cdd:COG2940   133 GT 134

Name

Accession

Description

Interval

E-value

SET_SETDB1

cd10517

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...

121-322

5.92e-134

Pssm-ID: 380915 [Multi-domain] Cd Length: 288 Bit Score: 397.04 E-value: 5.92e-134

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 121 KPFYYILDITYGKEDVPLSCVNEIDTTPPPQVAYSKERIPGKGVFINTGPEFLVGCDCKDGCRDKSKCACHQLTIQATAC 200
Cdd:cd10517     1 KPYYYICDISYGKEGVPIPCVNEIDNSSPPYVEYSKERIPGKGVNINLDPDFLVGCDCTDGCRDKSKCACQQLTIEATAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 201 TPGGQINPNSGYQYKRLEECLPTGVYECNKRCKCDpNMCTNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYA 280
Cdd:cd10517    81 TPGGQINPSAGYQYRRLMEKLPTGVYECNSRCKCD-KRCYNRVVQNGLQVRLQVFKTEKKGWGIRCLDDIPKGSFVCIYA 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 2462515956 281 GKILTDDFADKEGLEMGDEYFANLDHIESVENFKEGYESDAP 322
Cdd:cd10517   160 GQILTEDEANEEGLQYGDEYFAELDYIEVVEKLKEGYESDVE 201

SET_SETDB

cd10541

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1), ...

121-308

4.54e-93

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1), SET domain bifurcated 2 (SETDB2), and similar proteins; SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis.

Pssm-ID: 380939 [Multi-domain] Cd Length: 236 Bit Score: 289.44 E-value: 4.54e-93

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 121 KPFYYILDITYGKedvplscvneidttpppqvayskeripgkgvfintgpeFLVGCDCKDGCRDKSKCACHQLTIQATAC 200
Cdd:cd10541     1 KPFYYIPDISYGK--------------------------------------FLVGCDCTDGCRDKSKCACHQLTIQATAC 42

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 201 TPGGQINPNSGYQYKRLEECLPTGVYECNKRCKCDPNMCTNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYA 280
Cdd:cd10541    43 TPGGQDNPTAGYQYKRLEECLPTGVYECNKLCKCDPNMCQNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGTFVCIYA 122

                         170       180
                  ....*....|....*....|....*...
gi 2462515956 281 GKILTDDFADKEGLEMGDEYFANLDHIE 308
Cdd:cd10541   123 GKILTDDFADKEGLEMGDEYFANLDHIE 150

SET_SETDB1

cd10517

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...

649-738

9.69e-64

Pssm-ID: 380915 [Multi-domain] Cd Length: 288 Bit Score: 214.07 E-value: 9.69e-64

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 649 DGEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKRIRAGTELTWDYNYEVGSVEGKELLCCC 728
Cdd:cd10517   199 DVEEHCYIIDAKSEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASRYIRAGTELTWDYNYEVGSVPGKVLYCYC 278

                          90
                  ....*....|
gi 2462515956 729 GAIECRGRLL 738
Cdd:cd10517   279 GSSNCRGRLL 288

SET_SETDB

cd10541

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1), ...

651-737

3.64e-56

Pssm-ID: 380939 [Multi-domain] Cd Length: 236 Bit Score: 191.99 E-value: 3.64e-56

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 651 EESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKRIRAGTELTWDYNYEVGSVEGKELLCCCGA 730
Cdd:cd10541   150 EESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKRIKAGTELTWDYNYEVGSVEGKELLCCCGS 229


                  ....*..
gi 2462515956 731 IECRGRL 737
Cdd:cd10541   230 NECRGRL 236

SET_SETDB-like

cd10538

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...

154-321

1.95e-54

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2, and similar proteins; The family includes SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2. SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis. SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. This family also includes the pre-SET domain, which is found in a number of histone methyltransferases (HMTase), N-terminal to the SET domain. Pre-SET domain is a zinc binding motif which contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilizing SET domains. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.

Pssm-ID: 380936 [Multi-domain] Cd Length: 217 Bit Score: 186.42 E-value: 1.95e-54

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 154 YSKERIPGKGVFINTGPEFLVGCDCKDGCRDKsKCACHQLTiqatactpggqiNPNSGYQYKRLEE--CLPTGVYECNKR 231
Cdd:cd10538     5 YIKDNIVGKNVQPFSNIIDSVGCKCKDDCLDS-KCACAAES------------DGIFAYTKNGLLRlnNSPPPIFECNSK 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 232 CKCDPnMCTNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTDDFADKEGLE---MGDEYFANLDHIE 308
Cdd:cd10538    72 CSCDD-DCKNRVVQRGLQARLQVFRTSKKGWGVRSLEFIPKGSFVCEYVGEVITTSEADRRGKIydkSGGSYLFDLDEFS 150

                         170
                  ....*....|...
gi 2462515956 309 SVENFKEGYESDA 321
Cdd:cd10538   151 DSDGDGEELCVDA 163

SET_SETDB2

cd10523

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) ...

171-284

1.21e-49

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) and similar proteins; SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis.

Pssm-ID: 380921 [Multi-domain] Cd Length: 266 Bit Score: 175.02 E-value: 1.21e-49

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 171 EFLVGCDCKDGCRDKSKCACHQLTIQATACTPGGQINPNSGYQYKRLEECLPTGVYECNKRCKCDPNMCTNRLVQHGLQV 250
Cdd:cd10523    29 AFVDSCDCTDGCIDILKCACLQLTARAFSKSESSPSKGGRGYKYKRLQEPIPSGLYECNVSCKCNRMLCQNRVVQHGLQV 108

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2462515956 251 RLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKIL 284
Cdd:cd10523   109 RLQVFKTEKKGWGVRCLDDIDKGTFVCIYAGRVL 142

SET_SETDB2

cd10523

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) ...

650-737

1.74e-37

Pssm-ID: 380921 [Multi-domain] Cd Length: 266 Bit Score: 141.12 E-value: 1.74e-37

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 650 GEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKRIRAGTELTWDYNYEVGSVEGKELLCCCG 729
Cdd:cd10523   179 LRENVCFLDASKEGNVGRFLNHSCCPNLFVQNVFVDTHDKNFPWVAFFTNRVVKAGTELTWDYSYDAGTSPEQEIPCLCG 258


                  ....*...
gi 2462515956 730 AIECRGRL 737
Cdd:cd10523   259 VNKCQKKI 266

SET_AtSUVH-like

cd10545

SET domain found in Arabidopsis thaliana histone H3-K9 methyltransferases (SUVHs) and similar ...

175-328

7.64e-34

SET domain found in Arabidopsis thaliana histone H3-K9 methyltransferases (SUVHs) and similar proteins; Arabidopsis thaliana SUVH protein (also termed suppressor of variegation 3-9 homolog protein) is a histone-lysine N-methyltransferase that methylates 'Lys-9' of histone H3. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression. Some family members contain a post-SET domain which binds a Zn2+ ion. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.

Pssm-ID: 380943 [Multi-domain] Cd Length: 232 Bit Score: 129.45 E-value: 7.64e-34

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 175 GCDCKDGCRDKSK-CACHQLTiqatactpGGQINPNsgyQYKRLEECLPTgVYECNKRCKCdPNMCTNRLVQHGLQVRLQ 253
Cdd:cd10545    23 GCDCKNRCTDGASdCACVKKN--------GGEIPYN---FNGRLIRAKPA-IYECGPLCKC-PPSCYNRVTQKGLRYRLE 89

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462515956 254 LFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTDDFADKegLEMGDEYFANLDHIESVENFKEGYESDAPCSSDSS 328
Cdd:cd10545    90 VFKTAERGWGVRSWDSIPAGSFICEYVGELLDTSEADT--RSGNDDYLFDIDNRQTNRGWDGGQRLDVGMSDGER 162

SET_SUV39H

cd10542

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...

159-305

9.45e-34

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homologs, SUV39H1, SUV39H2 and similar proteins; This family includes SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. Also included are Schizosaccharomyces pombe H3K9 methyltransferase Clr4 (SUV39H homolog) and Neurospora crassa DIM-5, both of which also methylate 'Lys-9' of histone H3.

Pssm-ID: 380940 [Multi-domain] Cd Length: 245 Bit Score: 129.72 E-value: 9.45e-34

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 159 IPGKGVFINtgPEFLVGCDCKDGCRDKSKCACHQLTIQATACTPGGQINPNSGyqykrleeclpTGVYECNKRCKCDPNm 238
Cdd:cd10542    10 IPGDGVKIP--EDFLVGCECTEDCHNNNPTCCPAESGVKFAYDKQGRLRLPPG-----------TPIYECNSRCKCGPD- 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462515956 239 CTNRLVQHGLQVRLQLFKTQN-KGWGIRCLDDIAKGSFVCIYAGKILTDDFADKEGLE---MGDEYFANLD 305
Cdd:cd10542    76 CPNRVVQRGRKVPLCIFRTSNgRGWGVKTLEDIKKGTFVMEYVGEIITSEEAERRGKIydaNGRTYLFDLD 146

SET_SETDB-like

cd10538

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...

634-713

2.49e-28

Pssm-ID: 380936 [Multi-domain] Cd Length: 217 Bit Score: 113.23 E-value: 2.49e-28

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 634 KGESAPVRKNTRQFYDGEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKRIRAGTELTWDYN 713
Cdd:cd10538   138 SGGSYLFDLDEFSDSDGDGEELCVDATFCGNVSRFINHSCDPNLFPFNVVIDHDDLRYPRIALFATRDILPGEELTFDYG 217

SET_EHMT

cd10543

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...

166-321

9.57e-28

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase EHMT1, EHMT2 and similar proteins; This family includes EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.

Pssm-ID: 380941 [Multi-domain] Cd Length: 231 Bit Score: 112.05 E-value: 9.57e-28

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 166 INTGPEFLVGCDCKDGCrDKSKCACHQLTIQAtACTPGGQINPNsgyqykrLEECLPTGVYECNKRCKCDPNmCTNRLVQ 245
Cdd:cd10543    17 IDRNITSLQTCSCRDDC-SSDNCVCGRLSVRC-WYDKEGRLLPD-------FNKLDPPLIFECNRACSCWRN-CRNRVVQ 86

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462515956 246 HGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTDDFADKEGlemGDEYFANLDHIEsvenfKEGYESDA 321
Cdd:cd10543    87 NGIRYRLQLFRTRGMGWGVRALQDIPKGTFVCEYIGELISDSEADSRE---DDSYLFDLDNKD-----GETYCIDA 154

MBD

smart00391

Methyl-CpG binding domain; Methyl-CpG binding domain, also known as the TAM (TTF-IIP5, ARBP, ...

44-119

3.06e-27

Methyl-CpG binding domain; Methyl-CpG binding domain, also known as the TAM (TTF-IIP5, ARBP, MeCP1) domain

Pssm-ID: 128673 Cd Length: 77 Bit Score: 105.15 E-value: 3.06e-27

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462515956   44 KNPLLVPLLYDFRRMTARRRVNR-KMGFHVIYKTPCGLCLRTMQEIERYLFETGCDFLFLEMFCLDPYVLVDRKFQP 119
Cdd:smart00391   1 GDPLRLPLPCGWRRETKQRKSGRsAGKFDVYYISPCGKKLRSKSELARYLHKNGDLSLDLECFDFNATVPVGPKFTP 77

PreSET

smart00468

N-terminal to some SET domains; A Cys-rich putative Zn2+-binding domain that occurs N-terminal ...

126-233

3.70e-27

N-terminal to some SET domains; A Cys-rich putative Zn2+-binding domain that occurs N-terminal to some SET domains. Function is unknown. Unpublished.

Pssm-ID: 128744 [Multi-domain] Cd Length: 98 Bit Score: 105.58 E-value: 3.70e-27

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956  126 ILDITYGKEDVPLSCVNEID-TTPPPQVAYSKERIPGKGVFINTGPEFLVGCDCKDGCRDKSKCACHQLTiqatactpGG 204
Cdd:smart00468   1 CLDISNGKENVPVPLVNEVDeDPPPPDFEYISEYIYGQGVPIDRSPSPLVGCSCSGDCSSSNKCECARKN--------GG 72

                           90       100
                   ....*....|....*....|....*....
gi 2462515956  205 QINPNsgyQYKRLEECLPTGVYECNKRCK 233
Cdd:smart00468  73 EFAYE---LNGGLRLKRKPLIYECNSRCS 98

SET_SETMAR

cd10544

SET domain (including pre-SET and post-SET domains) found in SET domain and mariner ...

150-285

3.53e-26

SET domain (including pre-SET and post-SET domains) found in SET domain and mariner transposase fusion protein (SETMAR) and similar proteins; SETMAR (also termed metnase) is a DNA-binding protein that is indirectly recruited to sites of DNA damage through protein-protein interactions. It has a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity. SETMAR also acts as a histone-lysine N-methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3. It specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining.

Pssm-ID: 380942 [Multi-domain] Cd Length: 254 Bit Score: 108.15 E-value: 3.53e-26

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 150 PQVAYSKERIPGKGVFINTGPEFLVGCDCKDGcrdkskcACHQLTiqaTACTPGGQINPNSGyqykRLEECLPTG----V 225
Cdd:cd10544     1 PDFQYTPENVPGPGADTDPNEITFPGCDCKTS-------SCEPET---CSCLRKYGPNYDDD----GCLLDFDGKysgpV 66

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 226 YECNKRCKCDpNMCTNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILT 285
Cdd:cd10544    67 FECNSMCKCS-ESCQNRVVQNGLQFKLQVFKTPKKGWGLRTLEFIPKGRFVCEYAGEVIG 125

HMT_MBD

cd01395

Methyl-CpG binding domains (MBD) present in putative histone methyltransferases (HMT) such as ...

46-107

3.50e-25

Pssm-ID: 238689 Cd Length: 60 Bit Score: 98.61 E-value: 3.50e-25

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462515956  46 PLLVPLLYDFRRMTARRRVNrKMGFHVIYKTPCGLCLRTMQEIERYLFETgCDFLFLEMFCL 107
Cdd:cd01395     1 PLHTPLLCGFQRMKYRARVG-KVKKHVIYKAPCGRSLRNMSEVHRYLRET-CSFLTVDNFSF 60

SET_SUV39H

cd10542

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...

648-737

1.16e-23

Pssm-ID: 380940 [Multi-domain] Cd Length: 245 Bit Score: 100.45 E-value: 1.16e-23

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 648 YDGEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKRIRAGTELTWDYNY--EVGSVEGKE-- 723
Cdd:cd10542   147 YNDDDCEYTVDAAYYGNISHFINHSCDPNLAVYAVWINHLDPRLPRIAFFAKRDIKAGEELTFDYLMtgTGGSSESTIpk 226

                          90
                  ....*....|....*....
gi 2462515956 724 -----LLCCCGAIECRGRL 737
Cdd:cd10542   227 pkdvrVPCLCGSKNCRKYL 245

SET_SUV39H_DIM5-like

cd19473

SET domain (including pre-SET domain) found in Neurospora crassa (DIM-5) and similar proteins; ...

156-291

1.87e-23

SET domain (including pre-SET domain) found in Neurospora crassa (DIM-5) and similar proteins; This subfamily contains Neurospora crassa DIM-5 (also termed H3-K9-HMTase dim-5, or HKMT) which functions as histone-lysine N-methyltransferase that specifically trimethylates histone H3 to form H3K9me3.

Pssm-ID: 380996 [Multi-domain] Cd Length: 274 Bit Score: 100.85 E-value: 1.87e-23

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 156 KERIPGKGVfINTGPEFLVGCDCKDG--CRdKSKCAChqLTIQATACTPGGQINPNSGYQYKRLEECLPTG-------VY 226
Cdd:cd19473     7 EKSILGEGV-ELADEEFRSGCECTDDedCM-YSGCLC--LQDVDPDDDRDPGKKKNAYHSSGAKKGCLRGHmlnsrlpIY 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462515956 227 ECNKRCKCDPNmCTNRLVQHGLQVRLQLFKTQ-NKGWGIRCLDDIAKGSFVCIYAGKILTDDFADK 291
Cdd:cd19473    83 ECHEGCACSDD-CPNRVVERGRKVPLQIFRTSdGRGWGVRSTVDIKRGQFVDCYVGEIITPEEAQR 147

MBD

pfam01429

Methyl-CpG binding domain; The Methyl-CpG binding domain (MBD) binds to DNA that contains one ...

41-115

5.33e-23

Pssm-ID: 396147 [Multi-domain] Cd Length: 76 Bit Score: 93.19 E-value: 5.33e-23

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462515956  41 YRGKNPLLVPLLYDFRRMTARRRVNRKMG-FHVIYKTPCGLCLRTMQEIERYLFETGCDFLFLEMFCLDPYVLVDR 115
Cdd:pfam01429   1 IERKREDRLPLPPGWRREERQRKSGSKAGkVDVFYYSPTGKKLRSKSEVARYLEANGGTSPKLEDFSFTVRSEVGR 76

SET_EHMT1

cd10535

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...

176-306

8.16e-23

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins; EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, or lysine N-methyltransferase 1D (KMT1D)) acts as a histone-lysine N-methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.

Pssm-ID: 380933 [Multi-domain] Cd Length: 231 Bit Score: 97.70 E-value: 8.16e-23

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 176 CDCKDGCrDKSKCACHQLTIQATAcTPGGQINPnsgyQYKRLEeclPTGVYECNKRCKCDPNmCTNRLVQHGLQVRLQLF 255
Cdd:cd10535    27 CVCIDDC-SSSNCMCGQLSMRCWY-DKDGRLLP----EFNMAE---PPLIFECNHACSCWRN-CRNRVVQNGLRARLQLY 96

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2462515956 256 KTQNKGWGIRCLDDIAKGSFVCIYAGKILTDDFADkegLEMGDEYFANLDH 306
Cdd:cd10535    97 RTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEAD---VREEDSYLFDLDN 144

SET_AtSUVH-like

cd10545

SET domain found in Arabidopsis thaliana histone H3-K9 methyltransferases (SUVHs) and similar ...

645-714

4.71e-22

Pssm-ID: 380943 [Multi-domain] Cd Length: 232 Bit Score: 95.55 E-value: 4.71e-22

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462515956 645 RQFYDGEESC-YIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKRIRAGTELTWDYNY 714
Cdd:cd10545   162 RSSAEDEESSeFTIDAGSFGNVARFINHSCSPNLFVQCVLYDHNDLRLPRVMLFAADNIPPLQELTYDYGY 232

SET_EHMT

cd10543

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...

649-734

5.77e-22

Pssm-ID: 380941 [Multi-domain] Cd Length: 231 Bit Score: 95.10 E-value: 5.77e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 649 DGEESCyiIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKRIRAGTELTWDYNYEVGSVEGKELLCCC 728
Cdd:cd10543   146 DGETYC--IDARRYGNISRFINHLCEPNLIPVRVFVEHQDLRFPRIAFFASRDIKAGEELGFDYGEKFWRIKGKYFTCRC 223


                  ....*.
gi 2462515956 729 GAIECR 734
Cdd:cd10543   224 GSPKCK 229

SET_EHMT2

cd10533

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...

154-306

9.34e-22

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 2 (EHMT2) and similar proteins; EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C (KMT1C), or protein G9a) acts as a histone-lysine N-methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.

Pssm-ID: 380931 [Multi-domain] Cd Length: 239 Bit Score: 95.08 E-value: 9.34e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 154 YSKERIPGKGVFINTGPEFLVGCDCKDGCrDKSKCACHQLTIQATACTPGGQINpnsgyQYKRLEeclPTGVYECNKRCK 233
Cdd:cd10533     5 YISENCETSTMNIDRNITHLQHCTCVDDC-SSSNCLCGQLSIRCWYDKDGRLLQ-----EFNKIE---PPLIFECNQACS 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462515956 234 CDpNMCTNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTDDFADkegLEMGDEYFANLDH 306
Cdd:cd10533    76 CW-RNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEAD---VREDDSYLFDLDN 144

SET_SUV39H1

cd10525

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...

154-310

1.32e-21

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 1 (SUV39H1) and similar proteins; SUV39H1 (EC 2.1.1.43; also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A (KMT1A), position-effect variegation 3-9 homolog (SUV39H), or Su(var)3-9 homolog 1) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. It mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.

Pssm-ID: 380923 [Multi-domain] Cd Length: 255 Bit Score: 94.96 E-value: 1.32e-21

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 154 YSKERIPGKGVFINtgpEFLVGCDCKDGCRDKSKCACHQLTIQATACTPGGQInpnsgyqykRLEECLPtgVYECNKRCK 233
Cdd:cd10525     5 YINEYKVGEGVTLN---QVAVGCECQDCLSQPVGGCCPGASKHRFAYNEQGQV---------KVRPGLP--IYECNSRCR 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 234 CDPNmCTNRLVQHGLQVRLQLFKTQN-KGWGIRCLDDIAKGSFVCIYAGKILTDDFADKEGL---EMGDEYFANLDHIES 309
Cdd:cd10525    71 CGPD-CPNRVVQKGIQYDLCIFRTDNgRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQiydRQGATYLFDLDYVED 149


                  .
gi 2462515956 310 V 310
Cdd:cd10525   150 V 150

Pre-SET

pfam05033

Pre-SET motif; This protein motif is a zinc binding motif. It contains 9 conserved cysteines ...

129-242

4.02e-21

Pssm-ID: 461530 [Multi-domain] Cd Length: 99 Bit Score: 88.63 E-value: 4.02e-21

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 129 ITYGKEDVPLSCVNEID-TTPPPQVAYSKERIPGKGVFINtgpeFLVGCDCKDgCrDKSKCACHQLTiqatactpggQIN 207
Cdd:pfam05033   1 ISKGKENVPIPVVNEVDdEPPPPDFTYITSYIYPKEFLLI----IPQGCDCGD-C-SSEKCSCAQLN----------GGE 64

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2462515956 208 PNSGYQYK-RLEECLPTGVYECNKRCKCDPNmCTNR 242
Cdd:pfam05033  65 FRFPYDKDgLLVPESKPPIYECNPLCGCPPS-CPNR 99

SET_SETD2

cd19172

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and ...

641-735

1.35e-20

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and similar proteins; SETD2 (also termed HIF-1, huntingtin yeast partner B, huntingtin-interacting protein 1 (HIP-1), huntingtin-interacting protein B, lysine N-methyltransferase 3A or protein-lysine N-methyltransferase SETD2) acts as histone-lysine N-methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. It has been shown that methylation is a posttranslational modification of dynamic microtubules and that SETD2 methylates alpha-tubulin at lysine 40, the same lysine that is marked by acetylation on microtubules. Methylation of microtubules occurs during mitosis and cytokinesis and can be ablated by SETD2 deletion, which causes mitotic spindle and cytokinesis defects, micronuclei, and polyploidy.

Pssm-ID: 380949 [Multi-domain] Cd Length: 142 Bit Score: 88.41 E-value: 1.35e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 641 RKNTRQFY----DGEEscyIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDtHDLRfpwVAFFASKRIRAGTELTWDYNYEV 716
Cdd:cd19172    50 REGNRHYYfmalKSDE---IIDATKKGNLSRFINHSCEPNCETQKWTVN-GELR---VGFFAKRDIPAGEELTFDYQFER 122

                          90
                  ....*....|....*....
gi 2462515956 717 GSVEGKEllCCCGAIECRG 735
Cdd:cd19172   123 YGKEAQK--CYCGSPNCRG 139

MBD

cd00122

MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of ...

46-106

4.37e-20

MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding protein which binds specifically to methylated DNA. The MBD can recognize a single symmetrically methylated CpG either as naked DNA or within chromatin. MeCP2, MBD1 and MBD2 (and likely MBD3) form complexes with histone deacetylase and are involved in histone deacetylase-dependent repression of transcription. MBD4 is an endonuclease that forms a complex with the DNA mismatch-repair protein MLH1. The MBDs present in putative chromatin remodelling subunit, BAZ2A, and putative histone methyltransferase, CLLD8, represent two phylogenetically distinct groups within the MBD protein family.

Pssm-ID: 238069 Cd Length: 62 Bit Score: 84.30 E-value: 4.37e-20

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462515956  46 PLLVPLLYDFRRMTARRRVNRKMGFHVIYKTPCGLCLRTMQEIERYLFETGCDFLFLEMFC 106
Cdd:cd00122     1 PLRDPLPPGWKRELVIRKSGSAGKGDVYYYSPCGKKLRSKPEVARYLEKTGPSSLDLENFS 61

SET_SUV39H_Clr4-like

cd20073

SET domain (including pre-SET and post-SET domains) found in of Schizosaccharomyces pombe H3K9 ...

170-328

7.11e-20

SET domain (including pre-SET and post-SET domains) found in of Schizosaccharomyces pombe H3K9 methyltransferase Clr4, and similar proteins; This subfamily contains fission yeast Schizosaccharomyces pombe H3K9 methyltransferase Clr4 (also known as Suv39h), the sole homolog of the mammalian SUV39H1 and SUV39H2 enzymes, that has a critical role in preventing aberrant heterochromatin formation. It is known to di- and tri-methylate Lys-9 of histone H3, a central heterochromatic histone modification, with its specificity profile most similar to that of the human SUV39H2 homolog.

Pssm-ID: 380999 [Multi-domain] Cd Length: 259 Bit Score: 89.94 E-value: 7.11e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 170 PEFLVGCDC--KDGC--RDKSKCACHQltiqatactpgGQINPNSGY-QYKRLEECLPTGVYECNKRCKCDPNmCTNRLV 244
Cdd:cd20073    20 PLFISGCSCskLGGCdlNNPGSCQCLE-----------DSNEKSFAYdEYGRVRANTGSIIYECNENCDCGIN-CPNRVV 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 245 QHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTDDFADKEGL---EMGDEYFANLDHIESveNFKEGYESDA 321
Cdd:cd20073    88 QRGRKLPLEIFKTKHKGWGLRCPRFIKAGTFIGVYLGEVITQSEAEIRGKkydNVGVTYLFDLDLFED--QVDEYYTVDA 165


                  ....*..
gi 2462515956 322 PCSSDSS 328
Cdd:cd20073   166 QYCGDVT 172

SET_EHMT1

cd10535

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...

638-734

2.71e-19

Pssm-ID: 380933 [Multi-domain] Cd Length: 231 Bit Score: 87.68 E-value: 2.71e-19

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 638 APVRKNTRQFYD---GEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKRIRAGTELTWDYNY 714
Cdd:cd10535   130 ADVREEDSYLFDldnKDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGE 209

                          90       100
                  ....*....|....*....|
gi 2462515956 715 EVGSVEGKELLCCCGAIECR 734
Cdd:cd10535   210 RFWDIKGKLFSCRCGSPKCR 229

SET_SETD1-like

cd10518

SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), ...

645-734

3.13e-19

SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), histone-lysine N-methyltransferases (KMT2A/KMT2B/KMT2C/KMT2D) and similar proteins; This family includes SET domain-containing protein 1A (SETD1A), 1B (SETD1B), as well as histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B), 2C (KMT2C), 2D (KMT2D). These proteins are histone-lysine N-methyltransferases (EC 2.1.1.43) that specifically methylate 'Lys-4' of histone H3 (H3K4me).

Pssm-ID: 380916 Cd Length: 150 Bit Score: 84.96 E-value: 3.13e-19

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 645 RQFYDGEESCY--------IIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLrfpwVAFFASKRIRAGTELTWDYNYEv 716
Cdd:cd10518    59 RYDEEGGGGTYmfridedlVIDATKKGNIARFINHSCDPNCYAKIITVDGEKH----IVIFAKRDIAPGEELTYDYKFP- 133

                          90
                  ....*....|....*...
gi 2462515956 717 gSVEGKELLCCCGAIECR 734
Cdd:cd10518   134 -IEDEEKIPCLCGAPNCR 150

SET

smart00317

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...

653-715

8.14e-19

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues

Pssm-ID: 214614 [Multi-domain] Cd Length: 124 Bit Score: 82.77 E-value: 8.14e-19

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462515956  653 SCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDlrfpWVAFFASKRIRAGTELTWDYNYE 715
Cdd:smart00317  62 SDLCIDARRKGNLARFINHSCEPNCELLFVEVNGDD----RIVIFALRDIKPGEELTIDYGSD 120

SET_EHMT2

cd10533

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...

649-734

7.12e-18

Pssm-ID: 380931 [Multi-domain] Cd Length: 239 Bit Score: 83.53 E-value: 7.12e-18

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 649 DGEesCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKRIRAGTELTWDYNYEVGSVEGKELLCCC 728
Cdd:cd10533   146 DGE--VYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQC 223


                  ....*.
gi 2462515956 729 GAIECR 734
Cdd:cd10533   224 GSEKCK 229

SET_ASH1L

cd19174

SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ...

656-735

2.16e-17

SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ASH1L (EC 2.1.1.43; also termed absent small and homeotic disks protein 1 homolog, KMT2H, or lysine N-methyltransferase 2H) acts as histone-lysine N-methyltransferase that specifically methylates 'Lys-36' of histone H3 (H3K36me). It plays important roles in development; heterozygous mutation of ASH1L is associated with severe intellectual disability (ID) and multiple congenital anomaly (MCA).

Pssm-ID: 380951 [Multi-domain] Cd Length: 141 Bit Score: 79.26 E-value: 2.16e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 656 IIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHdlrfPWVAFFASKRIRAGTELTWDYNYEVGSVEgKELLCCCGAIECRG 735
Cdd:cd19174    63 VIDGYRMGNEARFVNHSCDPNCEMQKWSVNGV----YRIGLFALKDIPAGEELTYDYNFHSFNVE-KQQPCKCGSPNCRG 137

SET_SUV39H2

cd10532

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...

612-737

2.45e-17

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 2 (SUV39H2) and similar proteins; SUV39H2 (EC 2.1.1.43; also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B (KMT1B), or Su(var)3-9 homolog 2) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. It mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.

Pssm-ID: 380930 [Multi-domain] Cd Length: 243 Bit Score: 82.25 E-value: 2.45e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 612 RGFALKSTHGIAIKSTNMASVDKGESAPVRKNTRQFYDG-----------EESCYIIDAKLEGNLGRYLNHSCSPNLFVQ 680
Cdd:cd10532    95 RGWGVKTLQKIKKNSFVMEYVGEVITSEEAERRGQFYDSkgitylfdldyESDEFTVDAARYGNVSHFVNHSCDPNLQVF 174

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 681 NVFVDTHDLRFPWVAFFASKRIRAGTELTWDYNYEvGSVEGK-------------ELLCCCGAIECRGRL 737
Cdd:cd10532   175 NVFIDNLDTRLPRIALFSTRTIKAGEELTFDYQMK-GSGDLSsdsidnspakkrvRTVCKCGAVTCRGYL 243

SET_SUV39H1

cd10525

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...

649-720

3.47e-17

Pssm-ID: 380923 [Multi-domain] Cd Length: 255 Bit Score: 81.86 E-value: 3.47e-17

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462515956 649 DGEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKRIRAGTELTWDYNYEVGSVE 720
Cdd:cd10525   145 DYVEDVYTVDAAYYGNISHFVNHSCDPNLQVYNVFIDNLDERLPRIALFATRTIRAGEELTFDYNMQVDPVD 216

SET_SETD2-like

cd10531

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), ...

655-734

6.15e-17

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2), ASH1-like protein (ASH1L) and similar proteins; This family includes SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2) and ASH1-like protein (ASH1L), which function as histone-lysine N-methyltransferases. SETD2 specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. NSD2 shows histone H3 'Lys-27' (H3K27me) methyltransferase activity. ASH1L specifically methylates 'Lys-36' of histone H3 (H3K36me). The family also includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins.

Pssm-ID: 380929 Cd Length: 136 Bit Score: 78.07 E-value: 6.15e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 655 YIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHdlrfPWVAFFASKRIRAGTELTWDYNYEVGSVEGKEllCCCGAIECR 734
Cdd:cd10531    63 VVIDATRKGNLSRFINHSCEPNCETQKWIVNGE----YRIGIFALRDIPAGEELTFDYNFVNYNEAKQV--CLCGAQNCR 136

SET_KMT2C_2D

cd19171

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), ...

655-735

1.18e-16

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins; This family includes KMT2C and KMT2D. Both, KMT2C (also termed HALR or MLL3) and KMT2D (also termed ALR or MLL2), act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me). They are subunits of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation.

Pssm-ID: 380948 [Multi-domain] Cd Length: 153 Bit Score: 77.47 E-value: 1.18e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 655 YIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDthdlRFPWVAFFASKRIRAGTELTWDYNYEVGSvEGKELLCCCGAIECR 734
Cdd:cd19171    76 WVIDATMTGGPARYINHSCNPNCVAEVVTFD----KEKKIIIISNRRIAKGEELTYDYKFDFED-DQHKIPCLCGAPNCR 150


                  .
gi 2462515956 735 G 735
Cdd:cd19171   151 K 151

SET_SUV39H2

cd10532

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...

154-308

1.26e-16

Pssm-ID: 380930 [Multi-domain] Cd Length: 243 Bit Score: 79.93 E-value: 1.26e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 154 YSKERIPGKGvfINTGPEFLVGCDCKDGCRDKskcachqltiqataCTPGGqinpnSGYQY---KRLEECLPTG--VYEC 228
Cdd:cd10532     5 YINEYKPAPG--INLDNEATVGCDCSDCFFGK--------------CCPAE-----AGVLFaynEHGQLKIPPGtpIYEC 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 229 NKRCKCDPNmCTNRLVQHGLQVRLQLFKTQN-KGWGIRCLDDIAKGSFVCIYAGKILTDDFADKEGL---EMGDEYFANL 304
Cdd:cd10532    64 NSRCKCGPD-CPNRVVQKGTQYSLCIFRTSNgRGWGVKTLQKIKKNSFVMEYVGEVITSEEAERRGQfydSKGITYLFDL 142


                  ....
gi 2462515956 305 DHIE 308
Cdd:cd10532   143 DYES 146

SET_SETMAR

cd10544

SET domain (including pre-SET and post-SET domains) found in SET domain and mariner ...

656-737

1.59e-16

Pssm-ID: 380942 [Multi-domain] Cd Length: 254 Bit Score: 80.04 E-value: 1.59e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 656 IIDAKLEGNLGRYLNHSCSPNLFVQNVFVDThdlRFPWVAFFASKRIRAGTELTWDYNYEVG-SVEGKEL---------- 724
Cdd:cd10544   160 FVDPTYIGNIGRFLNHSCEPNLFMVPVRVDS---MVPKLALFAARDIVAGEELSFDYSGEFSnSVESVTLarqdesksrk 236

                          90
                  ....*....|...
gi 2462515956 725 LCCCGAIECRGRL 737
Cdd:cd10544   237 PCLCGAENCRGFL 249

SET

pfam00856

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...

647-713

9.65e-16

Pssm-ID: 459965 [Multi-domain] Cd Length: 115 Bit Score: 73.71 E-value: 9.65e-16

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462515956 647 FYDGEESCYIIDAKLE--GNLGRYLNHSCSPNLFVQNVFVDthdlRFPWVAFFASKRIRAGTELTWDYN 713
Cdd:pfam00856  51 FTLDEDSEYCIDARALyyGNWARFINHSCDPNCEVRVVYVN----GGPRIVIFALRDIKPGEELTIDYG 115

SET_NSD

cd19173

SET domain (including post-SET domain) found in nuclear SET domain-containing proteins, NSD1, ...

656-737

1.76e-15

SET domain (including post-SET domain) found in nuclear SET domain-containing proteins, NSD1, NSD2, NSD3 and similar proteins; The nuclear receptor-binding SET Domain (NSD) family of histone H3 lysine 36 methyltransferases is comprised of NSD1, NSD2, and NSD3, which are primarily known to be involved in chromatin integrity and gene expression through mono-, di-, or tri-methylating lysine 36 of histone H3 (H3K36), respectively. NSD1 (EC 2.1.1.43; also termed histone-lysine N-methyltransferase H3 lysine-36 and H4 lysine-20 specific, androgen receptor coactivator 267 kDa protein (ARA267), androgen receptor-associated protein of 267 kDa, H3-K36-HMTase, H4-K20-HMTase, lysine N-methyltransferase 3B (KMT3B) or NR-binding SET domain-containing protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4. NSD2 (EC 2.1.1.43; also termed multiple myeloma SET domain-containing protein (MMSET), protein trithorax-5 (TRX5), or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1)) acts as histone-lysine N-methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity. NSD3 (EC 2.1.1.43; also termed protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1L1), or WHSC1-like protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-4' and 'Lys-27' of histone H3.

Pssm-ID: 380950 [Multi-domain] Cd Length: 142 Bit Score: 73.89 E-value: 1.76e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 656 IIDAKLEGNLGRYLNHSCSPNLFVQNVFVDThDLRfpwVAFFASKRIRAGTELTWDYNYEVGSVEGKEllCCCGAIECRG 735
Cdd:cd19173    66 IIDAGPKGNLSRFMNHSCQPNCETQKWTVNG-DTR---VGLFAVRDIPAGEELTFNYNLDCLGNEKKV--CRCGAPNCSG 139


                  ..
gi 2462515956 736 RL 737
Cdd:cd19173   140 FL 141

SET_ASHR3-like

cd19175

SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 ...

656-737

2.72e-15

SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins; This family includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3, also termed protein SET DOMAIN GROUP 4 or protein stamen loss), ASH1 homolog 3 (ASHH3, also termed protein SET DOMAIN GROUP 7) and homolog 4 (ASHH4, also termed protein SET DOMAIN GROUP 24). They all function as histone-lysine N-methyltransferases (EC 2.1.1.43).

Pssm-ID: 380952 [Multi-domain] Cd Length: 139 Bit Score: 73.22 E-value: 2.72e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 656 IIDAKLEGNLGRYLNHSCSPNLFVQNVFVDThDLRfpwVAFFASKRIRAGTELTWDYNYevgSVEGKELLCCCGAIECRG 735
Cdd:cd19175    64 VIDATFKGNLSRFINHSCDPNCELQKWQVDG-ETR---IGVFAIRDIKKGEELTYDYQF---VQFGADQDCHCGSKNCRG 136


                  ..
gi 2462515956 736 RL 737
Cdd:cd19175   137 KL 138

SET

COG2940

SET domain-containing protein (function unknown) [General function prediction only];

655-736

3.90e-15

SET domain-containing protein (function unknown) [General function prediction only];

Pssm-ID: 442183 [Multi-domain] Cd Length: 134 Bit Score: 72.69 E-value: 3.90e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 655 YIIDAKLEGNLGRYLNHSCSPNLFVqnvfvdthDLRFPWVAFFASKRIRAGTELTWDYNYEvgsVEGKELLCCCGAieCR 734
Cdd:COG2940    66 GVIDGALGGNPARFINHSCDPNCEA--------DEEDGRIFIVALRDIAAGEELTYDYGLD---YDEEEYPCRCPN--CR 132


                  ..
gi 2462515956 735 GR 736
Cdd:COG2940   133 GT 134

SET_KMT2A_2B

cd19170

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), ...

652-737

7.04e-15

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins; This family includes KMT2A and KMT2B. Both KMT2A (also termed ALL-1 or CXXC7 or MLL or MLL1 or TRX1 or HRX) and KMT2B (also termed MLL4 or TRX2) act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me).

Pssm-ID: 380947 [Multi-domain] Cd Length: 152 Bit Score: 72.42 E-value: 7.04e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 652 ESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDlrfpWVAFFASKRIRAGTELTWDYNYevgSVEGKELLCCCGAI 731
Cdd:cd19170    73 DDDEVVDATMHGNAARFINHSCEPNCYSRVVNIDGKK----HIVIFALRRILRGEELTYDYKF---PIEDVKIPCTCGSK 145


                  ....*.
gi 2462515956 732 ECRGRL 737
Cdd:cd19170   146 KCRKYL 151

SET_SUV39H_Clr4-like

cd20073

SET domain (including pre-SET and post-SET domains) found in of Schizosaccharomyces pombe H3K9 ...

647-737

9.67e-13

Pssm-ID: 380999 [Multi-domain] Cd Length: 259 Bit Score: 68.75 E-value: 9.67e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 647 FYDGEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKRIRAGTELTWDY-----NYEVGSVEG 721
Cdd:cd20073   153 FEDQVDEYYTVDAQYCGDVTRFINHSCDPNLAIYSVLRDKSDSKIYDLAFFAIKDIPALEELTFDYsgrnnFDQLGFIGN 232

                          90       100
                  ....*....|....*....|....*.
gi 2462515956 722 K----------ELLCCCGAIECRGRL 737
Cdd:cd20073   233 RsnskyinlknKRPCYCGSANCRGWL 258

SET_KMT2B

cd19207

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2B (KMT2B) ...

646-734

4.47e-12

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2B (KMT2B) and similar proteins; KMT2B (EC2.1.1.43; also termed lysine N-methyltransferase 2B, myeloid/lymphoid or mixed-lineage leukemia protein 4 (MLL2/MLL4), trithorax homolog 2 (TRX2), or WW domain-binding protein 7 (WBP-7)), acts as a histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me). It is required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that precedes resumption of meiosis, oocyte survival and normal zygotic genome activation.

Pssm-ID: 380984 [Multi-domain] Cd Length: 154 Bit Score: 64.66 E-value: 4.47e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 646 QFYDGEE-SCY--------IIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDlrfpWVAFFASKRIRAGTELTWDYNYEV 716
Cdd:cd19207    58 KFYDSKGiGCYmfriddfdVVDATMHGNAARFINHSCEPNCYSRVIHVEGQK----HIVIFALRKIYRGEELTYDYKFPI 133

                          90
                  ....*....|....*...
gi 2462515956 717 GSVEGKeLLCCCGAIECR 734
Cdd:cd19207   134 EDASNK-LPCNCGAKRCR 150

SET_KMT2A

cd19206

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A) ...

646-734

4.52e-12

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A) and similar proteins; KMT2A (EC2.1.1.43; also termed lysine N-methyltransferase 2A, ALL-1, CXXC-type zinc finger protein 7 (CXXC7), myeloid/lymphoid or mixed-lineage leukemia (MLL), myeloid/lymphoid or mixed-lineage leukemia protein 1 (MLL1), trithorax-like protein (TRX1), or zinc finger protein HRX) acts as a histone methyltransferase that plays an essential role in early development and hematopoiesis. It is a catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac).

Pssm-ID: 380983 [Multi-domain] Cd Length: 154 Bit Score: 64.66 E-value: 4.52e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 646 QFYDGEE-SCY--------IIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDlrfpWVAFFASKRIRAGTELTWDYNYEV 716
Cdd:cd19206    58 KYYDSKGiGCYmfriddseVVDATMHGNAARFINHSCEPNCYSRVINIDGQK----HIVIFAMRKIYRGEELTYDYKFPI 133

                          90
                  ....*....|....*...
gi 2462515956 717 GSVeGKELLCCCGAIECR 734
Cdd:cd19206   134 EDA-SNKLPCNCGAKKCR 150

SET_SETD1

cd19169

SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and ...

655-734

5.86e-12

SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and similar proteins; This family includes SET domain-containing protein 1A (SETD1A) and SET domain-containing protein 1B (SETD1B). These proteins are histone-lysine N-methyltransferases that specifically methylate 'Lys-4' of histone H3 (H3K4me) when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated.

Pssm-ID: 380946 Cd Length: 148 Bit Score: 63.90 E-value: 5.86e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 655 YIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLrfpwVAFFASKRIRAGTELTWDYNYevgSVEGKELLCCCGAIECR 734
Cdd:cd19169    76 TIIDATKCGNLARFINHSCNPNCYAKIITVESQKK----IVIYSKRPIAVNEEITYDYKF---PIEDEKIPCLCGAPQCR 148

SET

cd08161

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, ...

665-713

2.18e-11

Pssm-ID: 380914 [Multi-domain] Cd Length: 72 Bit Score: 59.96 E-value: 2.18e-11

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2462515956 665 LGRYLNHSCSPNLFVQNVFVDTHdlrfPWVAFFASKRIRAGTELTWDYN 713
Cdd:cd08161    28 LARFINHSCEPNCEFEEVYVGGK----PRVFIVALRDIKAGEELTVDYG 72

SET_KMT2D

cd19209

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) ...

655-734

2.63e-11

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins; KMT2D (EC2.1.1.43; also termed lysine N-methyltransferase 2D, ALL1-related protein (ALR), or myeloid/lymphoid or mixed-lineage leukemia protein 2 (MLL2)), acts as histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me). It is a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription. KMT2D is a subunit of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation.

Pssm-ID: 380986 [Multi-domain] Cd Length: 155 Bit Score: 62.41 E-value: 2.63e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 655 YIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLrfpwVAFFASKRIRAGTELTWDYNYEVGSvEGKELLCCCGAIECR 734
Cdd:cd19209    78 HVIDATLTGGPARYINHSCAPNCVAEVVTFDKEDK----IIIISSRRIPKGEELTYDYQFDFED-DQHKIPCHCGAWNCR 152

SET_NSD1

cd19210

SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing ...

656-737

2.69e-11

SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins; NSD1 (EC 2.1.1.43; also termed Histone-lysine N-methyltransferase H3 lysine-36 and H4 lysine-20 specific, androgen receptor coactivator 267 kDa protein (ARA267), androgen receptor-associated protein of 267 kDa, H3-K36-HMTase, H4-K20-HMTase, lysine N-methyltransferase 3B (KMT3B), or NR-binding SET domain-containing protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4. NSD1 is altered in approximately 10% of head and neck cancer patients with 55% decrease in risk of death in NSD1-mutated versus non-mutated patients; its disruption promotes favorable chemotherapeutic responses linked to hypomethylation.

Pssm-ID: 380987 [Multi-domain] Cd Length: 142 Bit Score: 61.87 E-value: 2.69e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 656 IIDAKLEGNLGRYLNHSCSPNLFVQNVFVDThDLRfpwVAFFASKRIRAGTELTWDYNYE-VGSveGKElLCCCGAIECR 734
Cdd:cd19210    66 IIDAGPKGNYARFMNHCCQPNCETQKWTVNG-DTR---VGLFALCDIKAGTELTFNYNLEcLGN--GKT-VCKCGAPNCS 138


                  ...
gi 2462515956 735 GRL 737
Cdd:cd19210   139 GFL 141

SET_NSD2

cd19211

SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) ...

656-737

2.95e-11

SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins; NSD2 (EC 2.1.1.43; also termed multiple myeloma SET domain-containing protein (MMSET), protein trithorax-5 (TRX5), or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1)) acts as histone-lysine N-methyltransferase with histone H3 'Lys-36' (H3K36me) methyltransferase activity. NSD2 has been shown to mediate di- and trimethylation of H3K36 and dimethylation of H4K20 in different systems, and has been characterized as a transcriptional repressor interacting with histone deacetylase HDAC1 and histone demethylase LSD1. NSD2 mediates constitutive NF-kappaB signaling for cancer cell proliferation, survival and tumor growth. It is highly overexpressed in several types of human cancers, including small-cell lung cancers, neuroblastoma, carcinomas of stomach and colon, and bladder cancers, and its overexpression tends to be associated with tumor aggressiveness. WHSC1 is frequently deleted in Wolf-Hirschhorn syndrome (WHS).

Pssm-ID: 380988 [Multi-domain] Cd Length: 142 Bit Score: 61.93 E-value: 2.95e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 656 IIDAKLEGNLGRYLNHSCSPNLFVQNVFVDThDLRfpwVAFFASKRIRAGTELTWDYNYEVgsVEGKELLCCCGAIECRG 735
Cdd:cd19211    66 IIDAGPKGNYSRFMNHSCQPNCETQKWTVNG-DTR---VGLFAVCDIPAGTELTFNYNLDC--LGNEKTVCRCGAPNCSG 139


                  ..
gi 2462515956 736 RL 737
Cdd:cd19211   140 FL 141

SET_EZH

cd10519

SET domain found in enhancer of zeste homolog 1 (EZH1), zeste homolog 2 (EZH2) and similar ...

655-714

3.21e-11

SET domain found in enhancer of zeste homolog 1 (EZH1), zeste homolog 2 (EZH2) and similar proteins; The family includes EZH1 and EZH2. EZH1 (EC 2.1.1.43; also termed ENX-2, or histone-lysine N-methyltransferase EZH1) is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. EZH2 (EC 2.1.1.43; also termed lysine N-methyltransferase 6, ENX-1, or histone-lysine N-methyltransferase EZH2) is a catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Both, EZH1 and EZH2, can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively.

Pssm-ID: 380917 Cd Length: 117 Bit Score: 61.11 E-value: 3.21e-11

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 655 YIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDtHDLRfpwVAFFASKRIRAGTELTWDYNY 714
Cdd:cd10519    62 FVVDATRKGNKIRFANHSSNPNCYAKVMMVN-GDHR---IGIFAKRDIEAGEELFFDYGY 117

SET_LegAS4-like

cd10522

SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and ...

629-715

4.25e-11

SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and similar proteins; LegAS4 is a type IV secretion system effector of Legionella pneumophila. It contains a SET domain that is involved in the modification of Lys4 of histone H3 (H3K4) in the nucleolus of the host cell, thereby enhancing heterochromatic rDNA transcription. It also contains an ankyrin repeat domain of unknown function at its C-terminal region.

Pssm-ID: 380920 [Multi-domain] Cd Length: 122 Bit Score: 60.82 E-value: 4.25e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 629 MASVDKGESAPVRKNTRqfydgeeSCYIIDAKLEGNLGRYLNHSCSPNLFvqnvFVDTHDLRFPWVAFFASKRIRAGTEL 708
Cdd:cd10522    44 RDSVYHYDPLYPFDLNG-------DILVIDAGKKGNLTRFINHSDQPNLE----LIVRTLKGEQHIGFVAIRDIKPGEEL 112


                  ....*..
gi 2462515956 709 TWDYNYE 715
Cdd:cd10522   113 FISYGPK 119

SET_SUV39H_DIM5-like

cd19473

SET domain (including pre-SET domain) found in Neurospora crassa (DIM-5) and similar proteins; ...

653-737

5.60e-11

Pssm-ID: 380996 [Multi-domain] Cd Length: 274 Bit Score: 63.88 E-value: 5.60e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 653 SCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKRIRAGTELTWDY-------NYEVGSVEGKELL 725
Cdd:cd19473   181 DPYEIDGEFMSGPTRFINHSCDPNLRIFARVGDHADKHIHDLAFFAIKDIPRGTELTFDYvdgvtglDDDAGDEEKEKEM 260

                          90
                  ....*....|....
gi 2462515956 726 --CCCGAIECRGRL 737
Cdd:cd19473   261 tkCLCGSPKCRGYL 274

SET_NSD3

cd19212

SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing ...

656-737

1.14e-10

SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 3 (NSD3) and similar proteins; NSD3 (EC 2.1.1.43; also termed protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1L1), or WHSC1-like protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. NSD3 is amplified and overexpressed in multiple cancer types, including acute myeloid leukemia (AML), breast, lung, pancreatic and bladder cancers, as well as squamous cell carcinoma of the head and neck (SCCHN). NSD3 contributes to tumorigenesis by interacting with bromodomain-containing protein 4 (BRD4), the bromodomain and extraterminal (BET) protein, which is a potential therapeutic target in acute myeloid leukemia (AML). NSD3 is amplified in primary tumors and cell lines from breast carcinoma, and can promote the cell viability of small-cell lung cancer and pancreatic ductal adenocarcinoma. High NSD3 expression is implicated in poor grade and heavy smoking history in SCCHN. Thus, NSD3 may serve as a potential druggable target for selective cancer therapy.

Pssm-ID: 380989 [Multi-domain] Cd Length: 142 Bit Score: 60.32 E-value: 1.14e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 656 IIDAKLEGNLGRYLNHSCSPNLFVQNVFVDThDLRfpwVAFFASKRIRAGTELTWDYNYEVgsVEGKELLCCCGAIECRG 735
Cdd:cd19212    66 IIDAGPKGNYSRFMNHSCNPNCETQKWTVNG-DVR---VGLFALCDIPAGMELTFNYNLDC--LGNGRTECHCGADNCSG 139


                  ..
gi 2462515956 736 RL 737
Cdd:cd19212   140 FL 141

SET_SET1

cd20072

SET domain (including post-SET domain) found in catalytic component of the Saccharomyces ...

656-734

1.35e-10

SET domain (including post-SET domain) found in catalytic component of the Saccharomyces cerevisiae COMPASS complex and similar proteins; The family contains mostly fungal SET domains, including SET1 found in the catalytic component of the Saccharomyces cerevisiae COMPASS (complex of proteins associated with Set1). SET1 is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me), when part of the SET1 histone methyltransferase (HMT) complex. The activity of this catalytic domain is established through forming a complex with a set of core proteins; it is extensively contacted by Cps60 (Bre2), Cps50 (Swd1), and Cps30 (Swd3).

Pssm-ID: 380998 Cd Length: 148 Bit Score: 60.13 E-value: 1.35e-10

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462515956 656 IIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLrfpwVAFFASKRIRAGTELTWDYNYEvgsVEGKELLCCCGAIECR 734
Cdd:cd20072    77 VVDATKKGNIARFINHCCDPNCTAKIIKVEGEKR----IVIYAKRDIAAGEELTYDYKFP---REEDKIPCLCGAPNCR 148

SET_KMT2C

cd19208

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C) ...

655-734

2.51e-10

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C) and similar proteins; KMT2C (EC2.1.1.43; also termed lysine N-methyltransferase 2C, homologous to ALR protein (HALR) myeloid/lymphoid, or mixed-lineage leukemia protein 3 (MLL3)), acts as a histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me) and may be involved in leukemogenesis and developmental disorder. KMT2C is a catalytic subunit of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. Overexpression of KMT2C is associated with estrogen receptor-positive breast cancer; KMT2C mediates the estrogen dependence of breast cancer through regulation of estrogen receptor alpha (ERalpha) enhancer function. KMT2C is frequently mutated in certain populations with diffuse-type gastric adenocarcinomas (DGA); its loss promotes epithelial-to-mesenchymal transition (EMT) and is associated with worse overall survival.

Pssm-ID: 380985 [Multi-domain] Cd Length: 154 Bit Score: 59.64 E-value: 2.51e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 655 YIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDthdlRFPWVAFFASKRIRAGTELTWDYNYEVGSVEGKeLLCCCGAIECR 734
Cdd:cd19208    77 HVIDATLTGGPARYINHSCAPNCVAEVVTFE----KGHKIIISSSRRIQKGEELCYDYKFDFEDDQHK-IPCHCGAVNCR 151

SET_SETD1B

cd19205

SET domain (including post-SET domain) found in SET domain-containing protein 1B (SETD1B) and ...

656-737

1.01e-09

SET domain (including post-SET domain) found in SET domain-containing protein 1B (SETD1B) and similar proteins; SETD1B (EC2.1.1.43), also termed lysine N-methyltransferase 2G, is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me) when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. Loss of SETD1B occurs in up to half the gastric and colorectal cancers, most commonly via SETD1B mutations, while de novo variants in SETD1B are associated with intellectual disability, epilepsy and autism.

Pssm-ID: 380982 [Multi-domain] Cd Length: 153 Bit Score: 57.76 E-value: 1.01e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 656 IIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLrfpwVAFFASKRIRAGTELTWDYNYevgSVEGKELLCCCGAIECRG 735
Cdd:cd19205    78 IIDATKCGNFARFINHSCNPNCYAKVITVESQKK----IVIYSKQHINVNEEITYDYKF---PIEDVKIPCLCGSENCRG 150


                  ..
gi 2462515956 736 RL 737
Cdd:cd19205   151 TL 152

SET_SETD1A

cd19204

SET domain (including post-SET domain) found in SET domain-containing protein 1A (SETD1A) and ...

656-737

1.35e-09

SET domain (including post-SET domain) found in SET domain-containing protein 1A (SETD1A) and similar proteins; SETD1A (EC2.1.1.43), also termed lysine N-methyltransferase 2F, or Set1/Ash2 histone methyltransferase complex subunit SET1, is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me), when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. Human SET domain containing protein 1A (hSETD1A) expression occurs at a high rate in hepatocellular carcinoma patients and controls tumor metastasis in breast cancer by activating MMP expression.

Pssm-ID: 380981 [Multi-domain] Cd Length: 153 Bit Score: 57.34 E-value: 1.35e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 656 IIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLrfpwVAFFASKRIRAGTELTWDYNYevgSVEGKELLCCCGAIECRG 735
Cdd:cd19204    78 IIDATKCGNLARFINHCCTPNCYAKVITIESQKK----IVIYSKQPIGVNEEITYDYKF---PIEDNKIPCLCGTENCRG 150


                  ..
gi 2462515956 736 RL 737
Cdd:cd19204   151 TL 152

SET_SETD5-like

cd10529

SET domain found in SET domain-containing protein 5 (SETD5), inactive histone-lysine ...

647-714

3.60e-09

SET domain found in SET domain-containing protein 5 (SETD5), inactive histone-lysine N-methyltransferase 2E (KMT2E) and similar proteins; SETD5 is a probable transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. KMT2E (also termed inactive lysine N-methyltransferase 2E or myeloid/lymphoid or mixed-lineage leukemia protein 5 (MLL5)) associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. The family also includes Saccharomyces cerevisiae SET domain-containing proteins, SET3 and SET4, and Schizosaccharomyces pombe SET3. Most of these family members contain a post-SET domain which harbors a zinc-binding site.

Pssm-ID: 380927 Cd Length: 127 Bit Score: 55.36 E-value: 3.60e-09

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462515956 647 FYDGEESCYI-IDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFpwvAFFASKRIRAGTELT--WDYNY 714
Cdd:cd10529    60 FYDGFEGLPLcVDARKYGNEARFIRRSCRPNAELRHVVVSNGELRL---FIFALKDIRKGTEITipFDYDY 127

SET_ASH1L

cd19174

SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ...

252-306

4.27e-09

Pssm-ID: 380951 [Multi-domain] Cd Length: 141 Bit Score: 55.38 E-value: 4.27e-09

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2462515956 252 LQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTDDFADKeglEMGDEYFANLDH 306
Cdd:cd19174     2 LERFRTEDKGWGVRTKEPIKAGQFIIEYVGEVVSEQEFRR---RMIEQYHNHSHH 53

SET

smart00317

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...

250-313

1.20e-07

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues

Pssm-ID: 214614 [Multi-domain] Cd Length: 124 Bit Score: 50.80 E-value: 1.20e-07

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462515956  250 VRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTDDFADKEGLEMGDEYFANLDHIESVENF 313
Cdd:smart00317   1 NKLEVFKSPGKGWGVRATEDIPKGEFIGEYVGEIITSEEAEERPKAYDTDGAKAFYLFDIDSDL 64

SET_SMYD

cd20071

SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing ...

668-728

3.40e-07

SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing protein, and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1-SYMD5. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions.

Pssm-ID: 380997 [Multi-domain] Cd Length: 122 Bit Score: 49.68 E-value: 3.40e-07

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462515956 668 YLNHSCSPNLFVqnVFVDTHDLRfpwvaFFASKRIRAGTELTWDYNYEVGSVEG--KELL------CCC 728
Cdd:cd20071    58 LLNHSCDPNAVV--VFDGNGTLR-----VRALRDIKAGEELTISYIDPLLPRTErrRELLekygftCSC 119

SET_SETD8

cd10528

SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2. ...

655-712

3.55e-07

SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2.1.1.43; also termed N-lysine methyltransferase KMT5A, H4-K20-HMTase KMT5A, lysine N-methyltransferase 5A, lysine-specific methylase 5A, PR/SET domain-containing protein 07, PR-Set7 or PR/SET07) is a nucleosomal histone-lysine N-methyltransferase that specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). It plays a central role in the silencing of euchromatic genes.

Pssm-ID: 380926 [Multi-domain] Cd Length: 141 Bit Score: 49.88 E-value: 3.55e-07

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 655 YIIDAKLE-GNLGRYLNHSC-SPNLFVQNVFVDTHdlrfPWVAFFASKRIRAGTELTWDY 712
Cdd:cd10528    83 YCVDATKEsGRLGRLINHSKkKPNLKTKLLVIDGV----PHLILVAKRDIKPGEELLYDY 138

SET_SETD2-like

cd10531

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), ...

252-305

8.43e-07

Pssm-ID: 380929 Cd Length: 136 Bit Score: 48.79 E-value: 8.43e-07

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462515956 252 LQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTDDFADK-----EGLEMGDEYFANLD 305
Cdd:cd10531     2 LELFRTEKKGWGVKAKEDIQKGEFIIEYVGEVIDKKEFKErldeyEELGKSNFYILSLS 60

SET_SpSET3-like

cd19183

SET domain (including post-SET domain) found in Schizosaccharomyces pombe SET ...

657-712

3.30e-06

SET domain (including post-SET domain) found in Schizosaccharomyces pombe SET domain-containing protein 3 (SETD3) and similar proteins; Schizosaccharomyces pombe SETD3 functions as a transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. It is required for both, gene activation and repression.

Pssm-ID: 380960 Cd Length: 173 Bit Score: 47.78 E-value: 3.30e-06

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462515956 657 IDAKLEGNLGRYLNHSCSPNLFVQNVFVDthDLRFPWVAFFASKRIRAGTELT--WDY 712
Cdd:cd19183    69 IDTRRSGSVARFIRRSCRPNAELVTVASD--SGSVLKFVLYASRDISPGEEITigWDW 124

SET_EZH1

cd19217

SET domain found in enhancer of zeste homolog 1 (EZH1) and similar proteins; EZH1 (EC 2.1.1.43) ...

655-714

7.53e-06

SET domain found in enhancer of zeste homolog 1 (EZH1) and similar proteins; EZH1 (EC 2.1.1.43), also termed ENX-2, or histone-lysine N-methyltransferase EZH1, is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. It can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively.

Pssm-ID: 380994 Cd Length: 136 Bit Score: 46.21 E-value: 7.53e-06

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 655 YIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDThDLRfpwVAFFASKRIRAGTELTWDYNY 714
Cdd:cd19217    67 FVVDATRKGNKIRFANHSVNPNCYAKVVMVNG-DHR---IGIFAKRAIQQGEELFFDYRY 122

SET_EZH2

cd19218

SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins; EZH2 (EC 2.1.1.43) ...

655-714

1.04e-05

SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins; EZH2 (EC 2.1.1.43), also termed lysine N-methyltransferase 6, or ENX-1, or histone-lysine N-methyltransferase EZH2, is a catalytic subunit of the polycomb repressive complex 2 (PRC2)/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. It can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. PRC2 is involved in several cancers; EZH2 is overexpressed in breast, liver and prostate cancer, while point mutations in EZH2 alter the substrate preference and product specificity of PRC2 in Non-Hodgkin lymphomas (NHLs). Thus, PRC2 is a popular target for cancer therapeutics.

Pssm-ID: 380995 Cd Length: 120 Bit Score: 45.29 E-value: 1.04e-05

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 655 YIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDThDLRfpwVAFFASKRIRAGTELTWDYNY 714
Cdd:cd19218    65 FVVDATRKGNKIRFANHSVNPNCYAKVMMVNG-DHR---IGIFAKRAIQTGEELFFDYRY 120

SET_EZH-like

cd19168

SET domain found in enhancer of zeste homolog 1 (EZH1) and zeste homolog 2 (EZH2) of polycomb ...

657-712

3.43e-05

SET domain found in enhancer of zeste homolog 1 (EZH1) and zeste homolog 2 (EZH2) of polycomb repressive complex 2 (PRC2), and similar proteins; The family includes EZH1 and EZH2. EZH1 (EC 2.1.1.43; also termed ENX-2, or histone-lysine N-methyltransferase EZH1) is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. EZH2 (EC 2.1.1.43; also termed lysine N-methyltransferase 6, ENX-1, or histone-lysine N-methyltransferase EZH2) is a catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Both EZH1 and EZH2 can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. PRC2 is involved in several cancers; EZH2 is overexpressed in breast, liver and prostate cancer, while point mutations in EZH2 alter the substrate preference and product specificity of PRC2 in Non-Hodgkin lymphomas (NHLs). Thus, PRC2 is a popular target for cancer therapeutics.

Pssm-ID: 380945 Cd Length: 124 Bit Score: 44.10 E-value: 3.43e-05

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462515956 657 IDAKLEGNLGRYLNH----SCSPNLFVQNVFvDTHDLRfpwVAFFASKRIRAGTELTWDY 712
Cdd:cd19168    65 VDAAIYGNLSRYINHatdkVKTGNCMPKIMY-VNHEWR---IKFTAIKDIKIGEELFFNY 120

SET

pfam00856

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...

261-306

9.69e-05

Pssm-ID: 459965 [Multi-domain] Cd Length: 115 Bit Score: 42.51 E-value: 9.69e-05

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2462515956 261 GWGIRCLDDIAKGSFVCIYAGK-ILTDDFADKEGLEMGDEYFANLDH 306
Cdd:pfam00856   1 GRGLFATEDIPKGEFIGEYVEVlLITKEEADKRELLYYDKLELRLWG 47

SET_NSD1

cd19210

SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing ...

252-287

1.69e-04

Pssm-ID: 380987 [Multi-domain] Cd Length: 142 Bit Score: 42.22 E-value: 1.69e-04

                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2462515956 252 LQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTDD 287
Cdd:cd19210     4 VEIFRTLGRGWGLRCKTDIKKGEFVNEYVGELIDEE 39

SET_NSD

cd19173

SET domain (including post-SET domain) found in nuclear SET domain-containing proteins, NSD1, ...

250-284

4.62e-04

Pssm-ID: 380950 [Multi-domain] Cd Length: 142 Bit Score: 41.15 E-value: 4.62e-04

                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2462515956 250 VRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKIL 284
Cdd:cd19173     2 PPTEPFKTGDRGWGLRTKRDIKKGDFVIEYVGELI 36

SET_SETD2

cd19172

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and ...

251-284

9.42e-04

Pssm-ID: 380949 [Multi-domain] Cd Length: 142 Bit Score: 40.26 E-value: 9.42e-04

                          10        20        30
                  ....*....|....*....|....*....|....
gi 2462515956 251 RLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKIL 284
Cdd:cd19172     3 KVEVFRTEKKGWGLRAAEDLPKGTFVIEYVGEVL 36

SET_ASHR3-like

cd19175

SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 ...

251-286

4.37e-03

Pssm-ID: 380952 [Multi-domain] Cd Length: 139 Bit Score: 38.17 E-value: 4.37e-03

                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2462515956 251 RLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTD 286
Cdd:cd19175     1 KMKLVKTEKCGWGLVADEDINAGEFIIEYVGEVIDD 36

SET_KMT2E

cd19182

SET domain found in inactive histone-lysine N-methyltransferase 2E (KMT2E) and similar ...

648-717

5.85e-03

SET domain found in inactive histone-lysine N-methyltransferase 2E (KMT2E) and similar proteins; KMT2E (also termed inactive lysine N-methyltransferase 2E, myeloid/lymphoid or mixed-lineage leukemia protein 5 (MLL5)) plays a key role in hematopoiesis, spermatogenesis and cell cycle progression. It associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. Lack of key residues in the SET domain as well as the presence of an unusually large loop in the SET-I subdomain preclude the interaction of MLL5 SET with its cofactor and substrate thus making MLL5 devoid of any in vitro methyltransferase activity on full-length histones and histone H3 peptide.

Pssm-ID: 380959 Cd Length: 129 Bit Score: 37.56 E-value: 5.85e-03

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462515956 648 YDGEESCyiIDAKLEGNLGRYLNHSCSPNLFVQNVFVD--THdlrfpwVAFFASKRIRAGTELTWDYNYEVG 717
Cdd:cd19182    66 FHGLEMC--VDARTFGNEARFIRRSCTPNAEVRHVIEDgtIH------LYIYSIRSIPKGTEITIAFDFDYG 129

SET_SETD8

cd10528

SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2. ...

242-285

6.02e-03

Pssm-ID: 380926 [Multi-domain] Cd Length: 141 Bit Score: 37.94 E-value: 6.02e-03

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2462515956 242 RLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILT 285
Cdd:cd10528     9 ELILSGKEEGLKVIEIDGKGRGVIATRPFEKGDFVVEYHGDLIT 52

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01