|
Name |
Accession |
Description |
Interval |
E-value |
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
483-784 |
6.15e-36 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 139.01 E-value: 6.15e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 483 GHDDDILSLTIHPVKDYVATGqvGRDAAIHVWDTQTLKCLSLLKGqHQRGVCALDFSADGKCLVSVGLDdfHSIVFWDWK 562
Cdd:cd00200 7 GHTGGVTCVAFSPDGKLLATG--SGDGTIKVWDLETGELLRTLKG-HTGPVRDVAASADGTYLASGSSD--KTIRLWDLE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 563 KGEKIATTRGHKDKIFVVKCNPHHvdKLVTVGIKH--IKFWQ-QAGGGFTSKRGTFGSVgkletmMCVSYGRMEDLVFSG 639
Cdd:cd00200 82 TGECVRTLTGHTSYVSSVAFSPDG--RILSSSSRDktIKVWDvETGKCLTTLRGHTDWV------NSVAFSPDGTFVASS 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 640 AATGDIFIW--KDILLLKTVKAHDGPVFAMYALDKG--FVTGGKDGIVELWDDMFERCLKTYAIKRS---ALSTSSKGLL 712
Cdd:cd00200 154 SQDGTIKLWdlRTGKCVATLTGHTGEVNSVAFSPDGekLLSSSSDGTIKLWDLSTGKCLGTLRGHENgvnSVAFSPDGYL 233
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462573197 713 LednpsiraitlghghiLVGTKNGEILEID-KSGPMTLLVQGHmEGEVWGLAAHPLLPICATVSDDKTLRIWE 784
Cdd:cd00200 234 L----------------ASGSEDGTIRVWDlRTGECVQTLSGH-TNSVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
466-898 |
1.45e-34 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 138.12 E-value: 1.45e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 466 AVAVVYNRQQHSQRLYLGHDDDILSLTIHPVKDYVATGqvGRDAAIHVWDTQTLKCLSLLKGqHQRGVCALDFSADGKCL 545
Cdd:COG2319 59 TLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASA--SADGTVRLWDLATGLLLRTLTG-HTGAVRSVAFSPDGKTL 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 546 VSVGLDdfHSIVFWDWKKGEKIATTRGHKDKIFVVkcnphhvdklvtvgikhikfwqqagggftskrgTFGSVGKLetmm 625
Cdd:COG2319 136 ASGSAD--GTVRLWDLATGKLLRTLTGHSGAVTSV---------------------------------AFSPDGKL---- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 626 cvsygrmedlVFSGAATGDIFIWkDIL---LLKTVKAHDGPVFAM-YALD-KGFVTGGKDGIVELWDdmferclktyaik 700
Cdd:COG2319 177 ----------LASGSDDGTVRLW-DLAtgkLLRTLTGHTGAVRSVaFSPDgKLLASGSADGTVRLWD------------- 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 701 rsalstsskglllednpsiraitlghghilvgTKNGEILeidksgpmtLLVQGHmEGEVWGLAAHP---LLpicATVSDD 777
Cdd:COG2319 233 --------------------------------LATGKLL---------RTLTGH-SGSVRSVAFSPdgrLL---ASGSAD 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 778 KTLRIWELSAQHRMLAVRKLKKGGRCCAFSPDGKALAVGLNDGSFLVVNADTVEDMVSFHHRKEMISDIKFSKDtGKYLA 857
Cdd:COG2319 268 GTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD-GKTLA 346
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 2462573197 858 VASHDNFVDIYNVLTSKRVGICKGASSYITHIDWDSRGKLL 898
Cdd:COG2319 347 SGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTL 387
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
9-350 |
4.68e-33 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 133.50 E-value: 4.68e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 9 ATGGRDGCIRLWDTDfkpiTKIDLReTEQGYKGlSIRSVCWKAD--RLLAGTQDSEIfEVIVRERDKPMLILQGHcEGEL 86
Cdd:COG2319 94 ASASADGTVRLWDLA----TGLLLR-TLTGHTG-AVRSVAFSPDgkTLASGSADGTV-RLWDLATGKLLRTLTGH-SGAV 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 87 WALALHPKKPLAVTGSDDRSVRLWSLADHALIARCN-MEEAVRSVAFSPDGSQLALGMKDGSFIVLRVRDMTEVVHIKDR 165
Cdd:COG2319 166 TSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGH 245
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 166 KEVIHEMKFSPDGSYLAVGSNDGPVDVYAVAQrykkiGECSKSL----SFITHIDWSLDSKYLQTNDGAGERLFYRMPSG 241
Cdd:COG2319 246 SGSVRSVAFSPDGRLLASGSADGTVRLWDLAT-----GELLRTLtghsGGVNSVAFSPDGKLLASGSDDGTVRLWDLATG 320
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 242 KPLTSkeeIKGipwaswtcvkgpevsgiwpkytEVTDINSVDANYNSSVLVSGDDFGLVKLFKfpcLKRGAKFRKYVGHS 321
Cdd:COG2319 321 KLLRT---LTG----------------------HTGAVRSVAFSPDGKTLASGSDDGTVRLWD---LATGELLRTLTGHT 372
|
330 340
....*....|....*....|....*....
gi 2462573197 322 AHVTNVRWSHDFQWVLStGGADHSVFQWR 350
Cdd:COG2319 373 GAVTSVAFSPDGRTLAS-GSADGTVRLWD 400
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
1229-1714 |
2.15e-32 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 131.57 E-value: 2.15e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 1229 SATGKLLVSVGVDPEHTITVWRWQEGAKVASRGGHLERIFVVEFRPDSDTQFVSVGVKHMKFWTLAGSALLYKKGVIGSl 1308
Cdd:COG2319 1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTA- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 1309 gaakmqTMLSVAFGANNLTF-TGAINGDVYVWK-DHFLIRLVAKAHTGPVFTMyTTLRDG-LIVTGGkerptkEGGAVKL 1385
Cdd:COG2319 80 ------AVLSVAFSPDGRLLaSASADGTVRLWDlATGLLLRTLTGHTGAVRSV-AFSPDGkTLASGS------ADGTVRL 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 1386 WDqemkrcrafqLETGQLVEcvrsvcrgkgkilvgtkdgeiievgeknaasniLIDGHmEGEIWGLATHPSKDLFISASN 1465
Cdd:COG2319 147 WD----------LATGKLLR---------------------------------TLTGH-SGAVTSVAFSPDGKLLASGSD 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 1466 DGTARIWDLADKKLLNKVSlGHAA--RCAAYSPDGEMVAIGMKNGEFVILLVNSLKVWGKKRDRKSAIQDIRISPDNRFL 1543
Cdd:COG2319 183 DGTVRLWDLATGKLLRTLT-GHTGavRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLL 261
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 1544 AVGSSEHTVDFYDLTQGTNLNRIGyckDIPSFVIQMDFSADGKYIqVSTGAYKR-QVHEVPLGKQvteavviekitwasw 1622
Cdd:COG2319 262 ASGSADGTVRLWDLATGELLRTLT---GHSGGVNSVAFSPDGKLL-ASGSDDGTvRLWDLATGKL--------------- 322
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 1623 tsvlgdevigIWPRNADKADVNCACVTHAGLNIVTGDDFGLVKLFDfpcTEKFAKHKRYFGHSAHVTNIRFSYDDKYVVS 1702
Cdd:COG2319 323 ----------LRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWD---LATGELLRTLTGHTGAVTSVAFSPDGRTLAS 389
|
490
....*....|..
gi 2462573197 1703 tGGDDCSVFVWR 1714
Cdd:COG2319 390 -GSADGTVRLWD 400
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
638-1024 |
7.76e-27 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 115.01 E-value: 7.76e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 638 SGAATGDIFIWKDILLLKTVKAHDGPVF--AMYALDKGFVTGGKDGIVELWDdmferclktyaikrsALSTSSKGLLLED 715
Cdd:COG2319 55 AGDLTLLLLDAAAGALLATLLGHTAAVLsvAFSPDGRLLASASADGTVRLWD---------------LATGLLLRTLTGH 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 716 NPSIRAITLGH-GHILV-GTKNGEILEID-KSGPMTLLVQGHmEGEVWGLAAHP---LLpicATVSDDKTLRIWELSAQH 789
Cdd:COG2319 120 TGAVRSVAFSPdGKTLAsGSADGTVRLWDlATGKLLRTLTGH-SGAVTSVAFSPdgkLL---ASGSDDGTVRLWDLATGK 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 790 RMLAVRKLKKGGRCCAFSPDGKALAVGLNDGSFLVVNADTVEDMVSFHHRKEMISDIKFSKDtGKYLAVASHDNFVDIYN 869
Cdd:COG2319 196 LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPD-GRLLASGSADGTVRLWD 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 870 VLTSKRVGICKGASSYITHIDWDSRGKLLqVnSGAREqlffeaprgkrHIIRPseiekieWDTWTcvlgPTCEGIWPAHS 949
Cdd:COG2319 275 LATGELLRTLTGHSGGVNSVAFSPDGKLL-A-SGSDD-----------GTVRL-------WDLAT----GKLLRTLTGHT 330
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462573197 950 DitDVNAASLTKDCSLLATGDDFGFVKLFSYPVKGQHARFKkyvGHSAHVTNVRWLHNDSVLLTvGGADTALMIW 1024
Cdd:COG2319 331 G--AVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLT---GHTGAVTSVAFSPDGRTLAS-GSADGTVRLW 399
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
1171-1521 |
5.85e-22 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 98.18 E-value: 5.85e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 1171 HTDDILCLTVNQHPKYrnVVATSQIGTtpsIHIWDamtKHTLSMLRCF--HSKGVNYINFSATGKLLVSVGVDpeHTITV 1248
Cdd:cd00200 8 HTGGVTCVAFSPDGKL--LATGSGDGT---IKVWD---LETGELLRTLkgHTGPVRDVAASADGTYLASGSSD--KTIRL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 1249 WRWQEGAKVASRGGHLERIFVVEFRPDSdtQFVSVGVKH--MKFWTLAgsallykKGVIGSLGAAKMQTMLSVAF-GANN 1325
Cdd:cd00200 78 WDLETGECVRTLTGHTSYVSSVAFSPDG--RILSSSSRDktIKVWDVE-------TGKCLTTLRGHTDWVNSVAFsPDGT 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 1326 LTFTGAINGDVYVW--KDHFLIRlVAKAHTGPVFTMYTTLRDGLIVTGGkerptkEGGAVKLWDQEMKRCRAfqletgql 1403
Cdd:cd00200 149 FVASSSQDGTIKLWdlRTGKCVA-TLTGHTGEVNSVAFSPDGEKLLSSS------SDGTIKLWDLSTGKCLG-------- 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 1404 vecvrsvcrgkgkilvgtkdgeiievgeknaasniLIDGHmEGEIWGLATHPSKDLFISASNDGTARIWDLADKKLLNKV 1483
Cdd:cd00200 214 -----------------------------------TLRGH-ENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTL 257
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 2462573197 1484 SlGHAAR--CAAYSPDGEMVAIGMKNgefvillvNSLKVW 1521
Cdd:cd00200 258 S-GHTNSvtSLAWSPDGKRLASGSAD--------GTIRIW 288
|
|
| HELP |
pfam03451 |
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm ... |
426-473 |
4.97e-20 |
|
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.
Pssm-ID: 460922 Cd Length: 72 Bit Score: 85.68 E-value: 4.97e-20
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 2462573197 426 KREKAPEDSLKLQFIHGYRGYDCRNNLFYTQAGEVVYHIAAVAVVYNR 473
Cdd:pfam03451 25 QKKEPPDKKLKLEWVYGYRGKDCRSNLYYLPTGEIVYFTAAVVVLYDV 72
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
8-224 |
7.24e-19 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 88.93 E-value: 7.24e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 8 FATGGRDGCIRLWDTDFKpitkiDLRETEQGYKGlSIRSVCWKAD--RLLAGTQDSEIFevIVRERDKPML-ILQGHcEG 84
Cdd:cd00200 24 LATGSGDGTIKVWDLETG-----ELLRTLKGHTG-PVRDVAASADgtYLASGSSDKTIR--LWDLETGECVrTLTGH-TS 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 85 ELWALALHPKKPLAVTGSDDRSVRLWSLADHALIARCNM-EEAVRSVAFSPDGSQLALGMKDGSFIVLRVRDMTEVVHIK 163
Cdd:cd00200 95 YVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGhTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLT 174
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462573197 164 DRKEVIHEMKFSPDGSYLAVGSNDGPVDVYAVAQRyKKIGECSKSLSFITHIDWSLDSKYL 224
Cdd:cd00200 175 GHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG-KCLGTLRGHENGVNSVAFSPDGYLL 234
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
653-979 |
1.11e-18 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 88.55 E-value: 1.11e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 653 LLKTVKAHDGPVFAMYALDKG--FVTGGKDGIVELWD---DMFERCLKTYAIKRSALSTSSKGLLL----EDNpSIRait 723
Cdd:cd00200 1 LRRTLKGHTGGVTCVAFSPDGklLATGSGDGTIKVWDletGELLRTLKGHTGPVRDVAASADGTYLasgsSDK-TIR--- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 724 lghghiLVGTKNGEILEIdksgpmtllVQGHmEGEVWGLAAHPLLPICATVSDDKTLRIWELSAQHRMLAVRKLKKGGRC 803
Cdd:cd00200 77 ------LWDLETGECVRT---------LTGH-TSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNS 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 804 CAFSPDGKALAVGLNDGSFLVVNADTVEDMVSFHHRKEMISDIKFSKDtGKYLAVASHDNFVDIYNVLTSKRVGICKGAS 883
Cdd:cd00200 141 VAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPD-GEKLLSSSSDGTIKLWDLSTGKCLGTLRGHE 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 884 SYITHIDWDSRGKLLqvnSGAreqlffeaprgkrhiirpSEIEKIE-WDTWTCVLGPTCEGiwpaHSdiTDVNAASLTKD 962
Cdd:cd00200 220 NGVNSVAFSPDGYLL---ASG------------------SEDGTIRvWDLRTGECVQTLSG----HT--NSVTSLAWSPD 272
|
330
....*....|....*..
gi 2462573197 963 CSLLATGDDFGFVKLFS 979
Cdd:cd00200 273 GKRLASGSADGTIRIWD 289
|
|
| HELP |
pfam03451 |
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm ... |
1108-1159 |
6.90e-13 |
|
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.
Pssm-ID: 460922 Cd Length: 72 Bit Score: 65.27 E-value: 6.90e-13
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 2462573197 1108 KNNITKKKKLVEE-LALDHVFGYRGFDCRNNLHYLNDGaDIIFHTAAAGIVQN 1159
Cdd:pfam03451 20 KDDLDQKKEPPDKkLKLEWVYGYRGKDCRSNLYYLPTG-EIVYFTAAVVVLYD 71
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
1440-1473 |
2.05e-04 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 40.37 E-value: 2.05e-04
10 20 30
....*....|....*....|....*....|....
gi 2462573197 1440 IDGHmEGEIWGLATHPSKDLFISASNDGTARIWD 1473
Cdd:smart00320 8 LKGH-TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
1440-1473 |
3.24e-04 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 39.64 E-value: 3.24e-04
10 20 30
....*....|....*....|....*....|....
gi 2462573197 1440 IDGHmEGEIWGLATHPSKDLFISASNDGTARIWD 1473
Cdd:pfam00400 7 LEGH-TGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
73-111 |
6.14e-04 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 38.87 E-value: 6.14e-04
10 20 30
....*....|....*....|....*....|....*....
gi 2462573197 73 KPMLILQGHcEGELWALALHPKKPLAVTGSDDRSVRLWS 111
Cdd:pfam00400 2 KLLKTLEGH-TGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
518-560 |
9.71e-04 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 38.45 E-value: 9.71e-04
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 2462573197 518 TLKCLSLLKGqHQRGVCALDFSADGKCLVSVGLDdfHSIVFWD 560
Cdd:smart00320 1 SGELLKTLKG-HTGPVTSVAFSPDGKYLASGSDD--GTIKLWD 40
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
73-111 |
1.43e-03 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 38.06 E-value: 1.43e-03
10 20 30
....*....|....*....|....*....|....*....
gi 2462573197 73 KPMLILQGHcEGELWALALHPKKPLAVTGSDDRSVRLWS 111
Cdd:smart00320 3 ELLKTLKGH-TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
483-784 |
6.15e-36 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 139.01 E-value: 6.15e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 483 GHDDDILSLTIHPVKDYVATGqvGRDAAIHVWDTQTLKCLSLLKGqHQRGVCALDFSADGKCLVSVGLDdfHSIVFWDWK 562
Cdd:cd00200 7 GHTGGVTCVAFSPDGKLLATG--SGDGTIKVWDLETGELLRTLKG-HTGPVRDVAASADGTYLASGSSD--KTIRLWDLE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 563 KGEKIATTRGHKDKIFVVKCNPHHvdKLVTVGIKH--IKFWQ-QAGGGFTSKRGTFGSVgkletmMCVSYGRMEDLVFSG 639
Cdd:cd00200 82 TGECVRTLTGHTSYVSSVAFSPDG--RILSSSSRDktIKVWDvETGKCLTTLRGHTDWV------NSVAFSPDGTFVASS 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 640 AATGDIFIW--KDILLLKTVKAHDGPVFAMYALDKG--FVTGGKDGIVELWDDMFERCLKTYAIKRS---ALSTSSKGLL 712
Cdd:cd00200 154 SQDGTIKLWdlRTGKCVATLTGHTGEVNSVAFSPDGekLLSSSSDGTIKLWDLSTGKCLGTLRGHENgvnSVAFSPDGYL 233
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462573197 713 LednpsiraitlghghiLVGTKNGEILEID-KSGPMTLLVQGHmEGEVWGLAAHPLLPICATVSDDKTLRIWE 784
Cdd:cd00200 234 L----------------ASGSEDGTIRVWDlRTGECVQTLSGH-TNSVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
466-898 |
1.45e-34 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 138.12 E-value: 1.45e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 466 AVAVVYNRQQHSQRLYLGHDDDILSLTIHPVKDYVATGqvGRDAAIHVWDTQTLKCLSLLKGqHQRGVCALDFSADGKCL 545
Cdd:COG2319 59 TLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASA--SADGTVRLWDLATGLLLRTLTG-HTGAVRSVAFSPDGKTL 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 546 VSVGLDdfHSIVFWDWKKGEKIATTRGHKDKIFVVkcnphhvdklvtvgikhikfwqqagggftskrgTFGSVGKLetmm 625
Cdd:COG2319 136 ASGSAD--GTVRLWDLATGKLLRTLTGHSGAVTSV---------------------------------AFSPDGKL---- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 626 cvsygrmedlVFSGAATGDIFIWkDIL---LLKTVKAHDGPVFAM-YALD-KGFVTGGKDGIVELWDdmferclktyaik 700
Cdd:COG2319 177 ----------LASGSDDGTVRLW-DLAtgkLLRTLTGHTGAVRSVaFSPDgKLLASGSADGTVRLWD------------- 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 701 rsalstsskglllednpsiraitlghghilvgTKNGEILeidksgpmtLLVQGHmEGEVWGLAAHP---LLpicATVSDD 777
Cdd:COG2319 233 --------------------------------LATGKLL---------RTLTGH-SGSVRSVAFSPdgrLL---ASGSAD 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 778 KTLRIWELSAQHRMLAVRKLKKGGRCCAFSPDGKALAVGLNDGSFLVVNADTVEDMVSFHHRKEMISDIKFSKDtGKYLA 857
Cdd:COG2319 268 GTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD-GKTLA 346
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 2462573197 858 VASHDNFVDIYNVLTSKRVGICKGASSYITHIDWDSRGKLL 898
Cdd:COG2319 347 SGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTL 387
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
9-350 |
4.68e-33 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 133.50 E-value: 4.68e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 9 ATGGRDGCIRLWDTDfkpiTKIDLReTEQGYKGlSIRSVCWKAD--RLLAGTQDSEIfEVIVRERDKPMLILQGHcEGEL 86
Cdd:COG2319 94 ASASADGTVRLWDLA----TGLLLR-TLTGHTG-AVRSVAFSPDgkTLASGSADGTV-RLWDLATGKLLRTLTGH-SGAV 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 87 WALALHPKKPLAVTGSDDRSVRLWSLADHALIARCN-MEEAVRSVAFSPDGSQLALGMKDGSFIVLRVRDMTEVVHIKDR 165
Cdd:COG2319 166 TSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGH 245
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 166 KEVIHEMKFSPDGSYLAVGSNDGPVDVYAVAQrykkiGECSKSL----SFITHIDWSLDSKYLQTNDGAGERLFYRMPSG 241
Cdd:COG2319 246 SGSVRSVAFSPDGRLLASGSADGTVRLWDLAT-----GELLRTLtghsGGVNSVAFSPDGKLLASGSDDGTVRLWDLATG 320
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 242 KPLTSkeeIKGipwaswtcvkgpevsgiwpkytEVTDINSVDANYNSSVLVSGDDFGLVKLFKfpcLKRGAKFRKYVGHS 321
Cdd:COG2319 321 KLLRT---LTG----------------------HTGAVRSVAFSPDGKTLASGSDDGTVRLWD---LATGELLRTLTGHT 372
|
330 340
....*....|....*....|....*....
gi 2462573197 322 AHVTNVRWSHDFQWVLStGGADHSVFQWR 350
Cdd:COG2319 373 GAVTSVAFSPDGRTLAS-GSADGTVRLWD 400
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
1229-1714 |
2.15e-32 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 131.57 E-value: 2.15e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 1229 SATGKLLVSVGVDPEHTITVWRWQEGAKVASRGGHLERIFVVEFRPDSDTQFVSVGVKHMKFWTLAGSALLYKKGVIGSl 1308
Cdd:COG2319 1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTA- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 1309 gaakmqTMLSVAFGANNLTF-TGAINGDVYVWK-DHFLIRLVAKAHTGPVFTMyTTLRDG-LIVTGGkerptkEGGAVKL 1385
Cdd:COG2319 80 ------AVLSVAFSPDGRLLaSASADGTVRLWDlATGLLLRTLTGHTGAVRSV-AFSPDGkTLASGS------ADGTVRL 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 1386 WDqemkrcrafqLETGQLVEcvrsvcrgkgkilvgtkdgeiievgeknaasniLIDGHmEGEIWGLATHPSKDLFISASN 1465
Cdd:COG2319 147 WD----------LATGKLLR---------------------------------TLTGH-SGAVTSVAFSPDGKLLASGSD 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 1466 DGTARIWDLADKKLLNKVSlGHAA--RCAAYSPDGEMVAIGMKNGEFVILLVNSLKVWGKKRDRKSAIQDIRISPDNRFL 1543
Cdd:COG2319 183 DGTVRLWDLATGKLLRTLT-GHTGavRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLL 261
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 1544 AVGSSEHTVDFYDLTQGTNLNRIGyckDIPSFVIQMDFSADGKYIqVSTGAYKR-QVHEVPLGKQvteavviekitwasw 1622
Cdd:COG2319 262 ASGSADGTVRLWDLATGELLRTLT---GHSGGVNSVAFSPDGKLL-ASGSDDGTvRLWDLATGKL--------------- 322
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 1623 tsvlgdevigIWPRNADKADVNCACVTHAGLNIVTGDDFGLVKLFDfpcTEKFAKHKRYFGHSAHVTNIRFSYDDKYVVS 1702
Cdd:COG2319 323 ----------LRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWD---LATGELLRTLTGHTGAVTSVAFSPDGRTLAS 389
|
490
....*....|..
gi 2462573197 1703 tGGDDCSVFVWR 1714
Cdd:COG2319 390 -GSADGTVRLWD 400
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
1178-1558 |
2.23e-31 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 128.49 E-value: 2.23e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 1178 LTVNQHPKYRNVVATSQIGTT-------PSIHIWDAMTKHTLSMLRcFHSKGVNYINFSATGKLLVSVGVDpeHTITVWR 1250
Cdd:COG2319 72 ATLLGHTAAVLSVAFSPDGRLlasasadGTVRLWDLATGLLLRTLT-GHTGAVRSVAFSPDGKTLASGSAD--GTVRLWD 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 1251 WQEGAKVASRGGHLERIFVVEFRPDSdTQFVSVGV-KHMKFWTLAGSALLYKkgVIGSLGAAkmqtmLSVAFGANNLTF- 1328
Cdd:COG2319 149 LATGKLLRTLTGHSGAVTSVAFSPDG-KLLASGSDdGTVRLWDLATGKLLRT--LTGHTGAV-----RSVAFSPDGKLLa 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 1329 TGAINGDVYVW--KDHFLIRLVaKAHTGPVFTMyTTLRDG-LIVTGGkerptkEGGAVKLWDqemkrcrafqLETGQLVE 1405
Cdd:COG2319 221 SGSADGTVRLWdlATGKLLRTL-TGHSGSVRSV-AFSPDGrLLASGS------ADGTVRLWD----------LATGELLR 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 1406 cvrsvcrgkgkilvgtkdgeiievgeknaasniLIDGHmEGEIWGLATHPSKDLFISASNDGTARIWDLADKKLLNKVSl 1485
Cdd:COG2319 283 ---------------------------------TLTGH-SGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT- 327
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462573197 1486 GHAA--RCAAYSPDGEMVAIGMKNGEFVILLVNSLKVWGKKRDRKSAIQDIRISPDNRFLAVGSSEHTVDFYDLT 1558
Cdd:COG2319 328 GHTGavRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
476-829 |
1.35e-30 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 126.18 E-value: 1.35e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 476 HSQRLYLGHDDDILSLTIHPVKDYVATGqvGRDAAIHVWDTQTLKCLSLLKGqHQRGVCALDFSADGKCLVSVGLDdfHS 555
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSPDGKTLASG--SADGTVRLWDLATGKLLRTLTG-HSGAVTSVAFSPDGKLLASGSDD--GT 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 556 IVFWDWKKGEKIATTRGHKDKIFVVKCNPHHvDKLVTVGI-KHIKFWQQAGGGF-TSKRGTFGSVgkletmMCVSY---G 630
Cdd:COG2319 186 VRLWDLATGKLLRTLTGHTGAVRSVAFSPDG-KLLASGSAdGTVRLWDLATGKLlRTLTGHSGSV------RSVAFspdG 258
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 631 RmedLVFSGAATGDIFIW--KDILLLKTVKAHDGPVFAM-YALD-KGFVTGGKDGIVELWDdmferclktyaikrsalst 706
Cdd:COG2319 259 R---LLASGSADGTVRLWdlATGELLRTLTGHSGGVNSVaFSPDgKLLASGSDDGTVRLWD------------------- 316
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 707 sskglllednpsiraitlghghilvgTKNGEILEIdksgpmtllVQGHmEGEVWGLAAHPLLPICATVSDDKTLRIWELS 786
Cdd:COG2319 317 --------------------------LATGKLLRT---------LTGH-TGAVRSVAFSPDGKTLASGSDDGTVRLWDLA 360
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 2462573197 787 AQHRMLAVRKLKKGGRCCAFSPDGKALAVGLNDGSFLVVNADT 829
Cdd:COG2319 361 TGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
32-602 |
8.79e-30 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 123.87 E-value: 8.79e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 32 LRETEQGYKGLSIRSVCWKADRLLAGTQDSEIFEVIVRERDKPMLILQGHcEGELWALALHPKKPLAVTGSDDRSVRLWS 111
Cdd:COG2319 28 LLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGH-TAAVLSVAFSPDGRLLASASADGTVRLWD 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 112 LADHALIARCNM-EEAVRSVAFSPDGSQLALGMKDGSFIVLRVRDMTEVVHIKDRKEVIHEMKFSPDGSYLAVGSNDGPV 190
Cdd:COG2319 107 LATGLLLRTLTGhTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTV 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 191 DVYAVAQrykkiGECSKSL----SFITHIDWSLDSKYlqtndgagerlfyrmpsgkpltskeeikgipwaswtcvkgpev 266
Cdd:COG2319 187 RLWDLAT-----GKLLRTLtghtGAVRSVAFSPDGKL------------------------------------------- 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 267 sgiwpkytevtdinsvdanynssvLVSGDDFGLVKLFKfpcLKRGAKFRKYVGHSAHVTNVRWSHDFQWVLStGGADHSV 346
Cdd:COG2319 219 ------------------------LASGSADGTVRLWD---LATGKLLRTLTGHSGSVRSVAFSPDGRLLAS-GSADGTV 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 347 FQWRfipegvsngmletapqeggadsyseesdsdlsdvpeldsdieqeaqinydrqvykedlpqlkqqskeknhavpflk 426
Cdd:COG2319 271 RLWD---------------------------------------------------------------------------- 274
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 427 rekapedslklqfihgyrgydcrnnlfyTQAGEVVyhiaavavvynrqqhsqRLYLGHDDDILSLTIHPVKDYVATGqvG 506
Cdd:COG2319 275 ----------------------------LATGELL-----------------RTLTGHSGGVNSVAFSPDGKLLASG--S 307
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 507 RDAAIHVWDTQTLKCLSLLKGqHQRGVCALDFSADGKCLVSVGLDdfHSIVFWDWKKGEKIATTRGHKDKIFVVKCNPHH 586
Cdd:COG2319 308 DDGTVRLWDLATGKLLRTLTG-HTGAVRSVAFSPDGKTLASGSDD--GTVRLWDLATGELLRTLTGHTGAVTSVAFSPDG 384
|
570
....*....|....*..
gi 2462573197 587 vDKLVTVGI-KHIKFWQ 602
Cdd:COG2319 385 -RTLASGSAdGTVRLWD 400
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
638-1024 |
7.76e-27 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 115.01 E-value: 7.76e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 638 SGAATGDIFIWKDILLLKTVKAHDGPVF--AMYALDKGFVTGGKDGIVELWDdmferclktyaikrsALSTSSKGLLLED 715
Cdd:COG2319 55 AGDLTLLLLDAAAGALLATLLGHTAAVLsvAFSPDGRLLASASADGTVRLWD---------------LATGLLLRTLTGH 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 716 NPSIRAITLGH-GHILV-GTKNGEILEID-KSGPMTLLVQGHmEGEVWGLAAHP---LLpicATVSDDKTLRIWELSAQH 789
Cdd:COG2319 120 TGAVRSVAFSPdGKTLAsGSADGTVRLWDlATGKLLRTLTGH-SGAVTSVAFSPdgkLL---ASGSDDGTVRLWDLATGK 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 790 RMLAVRKLKKGGRCCAFSPDGKALAVGLNDGSFLVVNADTVEDMVSFHHRKEMISDIKFSKDtGKYLAVASHDNFVDIYN 869
Cdd:COG2319 196 LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPD-GRLLASGSADGTVRLWD 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 870 VLTSKRVGICKGASSYITHIDWDSRGKLLqVnSGAREqlffeaprgkrHIIRPseiekieWDTWTcvlgPTCEGIWPAHS 949
Cdd:COG2319 275 LATGELLRTLTGHSGGVNSVAFSPDGKLL-A-SGSDD-----------GTVRL-------WDLAT----GKLLRTLTGHT 330
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462573197 950 DitDVNAASLTKDCSLLATGDDFGFVKLFSYPVKGQHARFKkyvGHSAHVTNVRWLHNDSVLLTvGGADTALMIW 1024
Cdd:COG2319 331 G--AVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLT---GHTGAVTSVAFSPDGRTLAS-GSADGTVRLW 399
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
701-1024 |
7.76e-25 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 109.23 E-value: 7.76e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 701 RSALSTSSKGLLLEDNPSIRAITLGHGHILVGTKNGEILEIDKSGPMTLLVQGHmEGEVWGLAAHPLLPICATVSDDKTL 780
Cdd:COG2319 24 ALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGH-TAAVLSVAFSPDGRLLASASADGTV 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 781 RIWELSAQHRMLAVRKLKKGGRCCAFSPDGKALAVGLNDGSFLVVNADTVEDMVSFHHRKEMISDIKFSKDtGKYLAVAS 860
Cdd:COG2319 103 RLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPD-GKLLASGS 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 861 HDNFVDIYNVLTSKRVGICKGASSYITHIDWDSRGKLLQVNSGAREqlffeaprgkrhiIRPseiekieWDtwtcVLGPT 940
Cdd:COG2319 182 DDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGT-------------VRL-------WD----LATGK 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 941 CEGIWPAHSDitDVNAASLTKDCSLLATGDDFGFVKLFSyPVKGQHARFKKyvGHSAHVTNVRWLHNDSVLLTvGGADTA 1020
Cdd:COG2319 238 LLRTLTGHSG--SVRSVAFSPDGRLLASGSADGTVRLWD-LATGELLRTLT--GHSGGVNSVAFSPDGKLLAS-GSDDGT 311
|
....
gi 2462573197 1021 LMIW 1024
Cdd:COG2319 312 VRLW 315
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
9-196 |
2.62e-24 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 107.69 E-value: 2.62e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 9 ATGGRDGCIRLWDTDfkpiTKiDLRETEQGYKGlSIRSVCWKAD--RLLAGTQDSEIFeVIVRERDKPMLILQGHcEGEL 86
Cdd:COG2319 220 ASGSADGTVRLWDLA----TG-KLLRTLTGHSG-SVRSVAFSPDgrLLASGSADGTVR-LWDLATGELLRTLTGH-SGGV 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 87 WALALHPKKPLAVTGSDDRSVRLWSLADHALIARCNMEEA-VRSVAFSPDGSQLALGMKDGSFIVLRVRDMTEVVHIKDR 165
Cdd:COG2319 292 NSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGaVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGH 371
|
170 180 190
....*....|....*....|....*....|.
gi 2462573197 166 KEVIHEMKFSPDGSYLAVGSNDGPVDVYAVA 196
Cdd:COG2319 372 TGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
1159-1476 |
6.34e-24 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 106.53 E-value: 6.34e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 1159 NLSTGSQSFYLE-HTDDILCLTVnqHPKYRNVVATSQIGTtpsIHIWDAMTKHTLSMLRCfHSKGVNYINFSATGKLLVS 1237
Cdd:COG2319 106 DLATGLLLRTLTgHTGAVRSVAF--SPDGKTLASGSADGT---VRLWDLATGKLLRTLTG-HSGAVTSVAFSPDGKLLAS 179
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 1238 VGVDpeHTITVWRWQEGAKVASRGGHLERIFVVEFRPDSDTqFVSVGV-KHMKFWTLAGSALLYKKGviGSLGAAkmqtm 1316
Cdd:COG2319 180 GSDD--GTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKL-LASGSAdGTVRLWDLATGKLLRTLT--GHSGSV----- 249
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 1317 LSVAFGANNLTF-TGAINGDVYVWK-DHFLIRLVAKAHTGPVFTMYTTLRDGLIVTGGkerptkEGGAVKLWDqemkrcr 1394
Cdd:COG2319 250 RSVAFSPDGRLLaSGSADGTVRLWDlATGELLRTLTGHSGGVNSVAFSPDGKLLASGS------DDGTVRLWD------- 316
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 1395 afqLETGQLV-------ECVRSVC-RGKGKILV-GTKDGEI----IEVGEKNAAsnilIDGHmEGEIWGLATHPSKDLFI 1461
Cdd:COG2319 317 ---LATGKLLrtltghtGAVRSVAfSPDGKTLAsGSDDGTVrlwdLATGELLRT----LTGH-TGAVTSVAFSPDGRTLA 388
|
330
....*....|....*
gi 2462573197 1462 SASNDGTARIWDLAD 1476
Cdd:COG2319 389 SGSADGTVRLWDLAT 403
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
481-687 |
4.57e-23 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 101.26 E-value: 4.57e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 481 YLGHDDDILSLTIHPVKDYVATGqvGRDAAIHVWDTQTLKCLSLLKGqHQRGVCALDFSADGKCLVSVGLDdfHSIVFWD 560
Cdd:cd00200 89 LTGHTSYVSSVAFSPDGRILSSS--SRDKTIKVWDVETGKCLTTLRG-HTDWVNSVAFSPDGTFVASSSQD--GTIKLWD 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 561 WKKGEKIATTRGHKDKIFVVKCNPHHVDKLVTVGIKHIKFWQQAGGgftSKRGTFgsVGKLETMMCVSYGRMEDLVFSGA 640
Cdd:cd00200 164 LRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG---KCLGTL--RGHENGVNSVAFSPDGYLLASGS 238
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 2462573197 641 ATGDIFIW--KDILLLKTVKAHDGPVFAMYALDKG--FVTGGKDGIVELWD 687
Cdd:cd00200 239 EDGTIRVWdlRTGECVQTLSGHTNSVTSLAWSPDGkrLASGSADGTIRIWD 289
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
1171-1521 |
5.85e-22 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 98.18 E-value: 5.85e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 1171 HTDDILCLTVNQHPKYrnVVATSQIGTtpsIHIWDamtKHTLSMLRCF--HSKGVNYINFSATGKLLVSVGVDpeHTITV 1248
Cdd:cd00200 8 HTGGVTCVAFSPDGKL--LATGSGDGT---IKVWD---LETGELLRTLkgHTGPVRDVAASADGTYLASGSSD--KTIRL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 1249 WRWQEGAKVASRGGHLERIFVVEFRPDSdtQFVSVGVKH--MKFWTLAgsallykKGVIGSLGAAKMQTMLSVAF-GANN 1325
Cdd:cd00200 78 WDLETGECVRTLTGHTSYVSSVAFSPDG--RILSSSSRDktIKVWDVE-------TGKCLTTLRGHTDWVNSVAFsPDGT 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 1326 LTFTGAINGDVYVW--KDHFLIRlVAKAHTGPVFTMYTTLRDGLIVTGGkerptkEGGAVKLWDQEMKRCRAfqletgql 1403
Cdd:cd00200 149 FVASSSQDGTIKLWdlRTGKCVA-TLTGHTGEVNSVAFSPDGEKLLSSS------SDGTIKLWDLSTGKCLG-------- 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 1404 vecvrsvcrgkgkilvgtkdgeiievgeknaasniLIDGHmEGEIWGLATHPSKDLFISASNDGTARIWDLADKKLLNKV 1483
Cdd:cd00200 214 -----------------------------------TLRGH-ENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTL 257
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 2462573197 1484 SlGHAAR--CAAYSPDGEMVAIGMKNgefvillvNSLKVW 1521
Cdd:cd00200 258 S-GHTNSvtSLAWSPDGKRLASGSAD--------GTIRIW 288
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
279-870 |
1.27e-20 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 96.52 E-value: 1.27e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 279 INSVDANYNSSVLVSGDDFGLVKLFKfpcLKRGAKFRKYVGHSAHVTNVRWSHDFQWVLStGGADHSVFQWRfipegvsn 358
Cdd:COG2319 81 VLSVAFSPDGRLLASASADGTVRLWD---LATGLLLRTLTGHTGAVRSVAFSPDGKTLAS-GSADGTVRLWD-------- 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 359 gmletapqeggadsyseesdsdlsdvpeldsdieqeaqinydrqvykedlpqlkqqskeknhavpflkrekapedslklq 438
Cdd:COG2319 --------------------------------------------------------------------------------
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 439 fihgyrgydcrnnlfyTQAGEVVYHIAavavvynrqqhsqrlylGHDDDILSLTIHPVKDYVATGqvGRDAAIHVWDTQT 518
Cdd:COG2319 149 ----------------LATGKLLRTLT-----------------GHSGAVTSVAFSPDGKLLASG--SDDGTVRLWDLAT 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 519 LKCLSLLKGqHQRGVCALDFSADGKCLVSVGLDdfHSIVFWDWKKGEKIATTRGHKDKIFvvkcnphhvdklvtvgikhi 598
Cdd:COG2319 194 GKLLRTLTG-HTGAVRSVAFSPDGKLLASGSAD--GTVRLWDLATGKLLRTLTGHSGSVR-------------------- 250
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 599 kfwqqagggftskrgtfgsvgkletmmcvsygrmeDLVFSgaatgdifiwkdilllktvkaHDGPVFAmyaldkgfvTGG 678
Cdd:COG2319 251 -----------------------------------SVAFS---------------------PDGRLLA---------SGS 265
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 679 KDGIVELWDdmferclktyaikrsalstsskglllednpsiraitlghghilvgTKNGEILEidksgpmtlLVQGHmEGE 758
Cdd:COG2319 266 ADGTVRLWD---------------------------------------------LATGELLR---------TLTGH-SGG 290
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 759 VWGLAAHP---LLpicATVSDDKTLRIWELSAQHRMLAVRKLKKGGRCCAFSPDGKALAVGLNDGSFLVVNADTVEDMVS 835
Cdd:COG2319 291 VNSVAFSPdgkLL---ASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRT 367
|
570 580 590
....*....|....*....|....*....|....*
gi 2462573197 836 FHHRKEMISDIKFSKDtGKYLAVASHDNFVDIYNV 870
Cdd:COG2319 368 LTGHTGAVTSVAFSPD-GRTLASGSADGTVRLWDL 401
|
|
| HELP |
pfam03451 |
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm ... |
426-473 |
4.97e-20 |
|
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.
Pssm-ID: 460922 Cd Length: 72 Bit Score: 85.68 E-value: 4.97e-20
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 2462573197 426 KREKAPEDSLKLQFIHGYRGYDCRNNLFYTQAGEVVYHIAAVAVVYNR 473
Cdd:pfam03451 25 QKKEPPDKKLKLEWVYGYRGKDCRSNLYYLPTGEIVYFTAAVVVLYDV 72
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
1219-1556 |
5.63e-20 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 92.40 E-value: 5.63e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 1219 HSKGVNYINFSATGKLLVSVGVDpeHTITVWRWQEGAKVASRGGHLERIFVVEFRPDSdTQFVSVGVKHM-KFWTLAGSA 1297
Cdd:cd00200 8 HTGGVTCVAFSPDGKLLATGSGD--GTIKVWDLETGELLRTLKGHTGPVRDVAASADG-TYLASGSSDKTiRLWDLETGE 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 1298 LLYkkgvigSLGAAKmQTMLSVAFGANNLTFTGAI-NGDVYVWK-DHFLIRLVAKAHTGPVFTMyTTLRDGLIVTGGKEr 1375
Cdd:cd00200 85 CVR------TLTGHT-SYVSSVAFSPDGRILSSSSrDKTIKVWDvETGKCLTTLRGHTDWVNSV-AFSPDGTFVASSSQ- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 1376 ptkeGGAVKLWDqemkrcrafqLETGQLVEcvrsvcrgkgkilvgtkdgeiievgeknaasniLIDGHmEGEIWGLATHP 1455
Cdd:cd00200 156 ----DGTIKLWD----------LRTGKCVA---------------------------------TLTGH-TGEVNSVAFSP 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 1456 SKDLFISASNDGTARIWDLADKKLLnKVSLGH--AARCAAYSPDGEMVAIGMKNGefvillvnSLKVW-GKKRDRK---- 1528
Cdd:cd00200 188 DGEKLLSSSSDGTIKLWDLSTGKCL-GTLRGHenGVNSVAFSPDGYLLASGSEDG--------TIRVWdLRTGECVqtls 258
|
330 340 350
....*....|....*....|....*....|.
gi 2462573197 1529 ---SAIQDIRISPDNRFLAVGSSEHTVDFYD 1556
Cdd:cd00200 259 ghtNSVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
1350-1714 |
1.31e-19 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 91.24 E-value: 1.31e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 1350 KAHTGPVFTMYTTLRDGLIVTGGkerptkEGGAVKLWDQEMKRC-RAFQLETGQlVECVRSVCRGKgKILVGTKDGEIIE 1428
Cdd:cd00200 6 KGHTGGVTCVAFSPDGKLLATGS------GDGTIKVWDLETGELlRTLKGHTGP-VRDVAASADGT-YLASGSSDKTIRL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 1429 VGEKNAASNILIDGHmEGEIWGLATHPSKDLFISASNDGTARIWDLADKKLLnKVSLGH--AARCAAYSPDGEMVAIGMK 1506
Cdd:cd00200 78 WDLETGECVRTLTGH-TSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCL-TTLRGHtdWVNSVAFSPDGTFVASSSQ 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 1507 NGefvillvnSLKVW----GKKRDR----KSAIQDIRISPDNRFLAVGSSEHTVDFYDLTQGTNLNRIGYCKDipsFVIQ 1578
Cdd:cd00200 156 DG--------TIKLWdlrtGKCVATltghTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHEN---GVNS 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 1579 MDFSADGKYIqvstgaykrqvhevplgkqvteavviekitwaswTSVLGDEVIGIWprnadkadvncacvthaglNIVTG 1658
Cdd:cd00200 225 VAFSPDGYLL----------------------------------ASGSEDGTIRVW-------------------DLRTG 251
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 2462573197 1659 DdfglvklfdfpctekfaKHKRYFGHSAHVTNIRFSYDDKYVVStGGDDCSVFVWR 1714
Cdd:cd00200 252 E-----------------CVQTLSGHTNSVTSLAWSPDGKRLAS-GSADGTIRIWD 289
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
8-224 |
7.24e-19 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 88.93 E-value: 7.24e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 8 FATGGRDGCIRLWDTDFKpitkiDLRETEQGYKGlSIRSVCWKAD--RLLAGTQDSEIFevIVRERDKPML-ILQGHcEG 84
Cdd:cd00200 24 LATGSGDGTIKVWDLETG-----ELLRTLKGHTG-PVRDVAASADgtYLASGSSDKTIR--LWDLETGECVrTLTGH-TS 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 85 ELWALALHPKKPLAVTGSDDRSVRLWSLADHALIARCNM-EEAVRSVAFSPDGSQLALGMKDGSFIVLRVRDMTEVVHIK 163
Cdd:cd00200 95 YVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGhTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLT 174
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462573197 164 DRKEVIHEMKFSPDGSYLAVGSNDGPVDVYAVAQRyKKIGECSKSLSFITHIDWSLDSKYL 224
Cdd:cd00200 175 GHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG-KCLGTLRGHENGVNSVAFSPDGYLL 234
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
653-979 |
1.11e-18 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 88.55 E-value: 1.11e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 653 LLKTVKAHDGPVFAMYALDKG--FVTGGKDGIVELWD---DMFERCLKTYAIKRSALSTSSKGLLL----EDNpSIRait 723
Cdd:cd00200 1 LRRTLKGHTGGVTCVAFSPDGklLATGSGDGTIKVWDletGELLRTLKGHTGPVRDVAASADGTYLasgsSDK-TIR--- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 724 lghghiLVGTKNGEILEIdksgpmtllVQGHmEGEVWGLAAHPLLPICATVSDDKTLRIWELSAQHRMLAVRKLKKGGRC 803
Cdd:cd00200 77 ------LWDLETGECVRT---------LTGH-TSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNS 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 804 CAFSPDGKALAVGLNDGSFLVVNADTVEDMVSFHHRKEMISDIKFSKDtGKYLAVASHDNFVDIYNVLTSKRVGICKGAS 883
Cdd:cd00200 141 VAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPD-GEKLLSSSSDGTIKLWDLSTGKCLGTLRGHE 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 884 SYITHIDWDSRGKLLqvnSGAreqlffeaprgkrhiirpSEIEKIE-WDTWTCVLGPTCEGiwpaHSdiTDVNAASLTKD 962
Cdd:cd00200 220 NGVNSVAFSPDGYLL---ASG------------------SEDGTIRvWDLRTGECVQTLSG----HT--NSVTSLAWSPD 272
|
330
....*....|....*..
gi 2462573197 963 CSLLATGDDFGFVKLFS 979
Cdd:cd00200 273 GKRLASGSADGTIRIWD 289
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
49-687 |
4.10e-18 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 88.81 E-value: 4.10e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 49 WKADRLLAGTQDSEIFEVIVRERDKPMLILQGHCEGELWALALHPKKPLAVTGSDDRSVRLWSLADHALIARCNMEEAVR 128
Cdd:COG2319 3 SADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 129 SVAFSPDGSQLALGMKDGSFIVLRVRDMTEVVHIKDRKEVIHEMKFSPDGSYLAVGSNDGPVDVyavaqrykkigecsks 208
Cdd:COG2319 83 SVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRL---------------- 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 209 lsfithidWSLDSkylqtndgagerlfyrmpsGKPLtskeeikgipwaswtcvkgpevsgiwpkytevtdinsvdanyns 288
Cdd:COG2319 147 --------WDLAT-------------------GKLL-------------------------------------------- 155
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 289 svlvsgddfglvklfkfpclkrgakfRKYVGHSAHVTNVRWSHDFQWvLSTGGADHSVFQWRfipegvsngmletapqeg 368
Cdd:COG2319 156 --------------------------RTLTGHSGAVTSVAFSPDGKL-LASGSDDGTVRLWD------------------ 190
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 369 gadsyseesdsdlsdvpeldsdieqeaqinydrqvykedlpqlkqqskeknhavpflkrekapedslklqfihgyrgydc 448
Cdd:COG2319 --------------------------------------------------------------------------------
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 449 rnnlfyTQAGEVVyhiaavavvynrqqhsqRLYLGHDDDILSLTIHPVKDYVATGqvGRDAAIHVWDTQTLKCLSLLKGq 528
Cdd:COG2319 191 ------LATGKLL-----------------RTLTGHTGAVRSVAFSPDGKLLASG--SADGTVRLWDLATGKLLRTLTG- 244
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 529 HQRGVCALDFSADGKCLVSVGLDdfHSIVFWDWKKGEKIATTRGHKDKIFVVKCNPhhvD--KLVTVGI-KHIKFWQQAG 605
Cdd:COG2319 245 HSGSVRSVAFSPDGRLLASGSAD--GTVRLWDLATGELLRTLTGHSGGVNSVAFSP---DgkLLASGSDdGTVRLWDLAT 319
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 606 GgftSKRGTFGsvGKLETMMCVSYGRMEDLVFSGAATGDIFIW--KDILLLKTVKAHDGPVFAMYALDKG--FVTGGKDG 681
Cdd:COG2319 320 G---KLLRTLT--GHTGAVRSVAFSPDGKTLASGSDDGTVRLWdlATGELLRTLTGHTGAVTSVAFSPDGrtLASGSADG 394
|
....*.
gi 2462573197 682 IVELWD 687
Cdd:COG2319 395 TVRLWD 400
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
1440-1714 |
5.43e-18 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 86.23 E-value: 5.43e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 1440 IDGHmEGEIWGLATHPSKDLFISASNDGTARIWDLADKKLLNKVSlGHAA--RCAAYSPDGEMVAIGMKNgefvillvNS 1517
Cdd:cd00200 5 LKGH-TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLK-GHTGpvRDVAASADGTYLASGSSD--------KT 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 1518 LKVW----GKKRDR----KSAIQDIRISPDNRFLAVGSSEHTVDFYDLTQGTNLNRIGYCKDipsFVIQMDFSADGKYiq 1589
Cdd:cd00200 75 IRLWdletGECVRTltghTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTD---WVNSVAFSPDGTF-- 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 1590 VSTGAYKRQVH--EVPLGKqvteavVIEKITwaswtsvlgdevigiwprnADKADVNCACVTHAGLNIVTGDDFGLVKLF 1667
Cdd:cd00200 150 VASSSQDGTIKlwDLRTGK------CVATLT-------------------GHTGEVNSVAFSPDGEKLLSSSSDGTIKLW 204
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 2462573197 1668 DFpctEKFAKHKRYFGHSAHVTNIRFSYDDKYVVStGGDDCSVFVWR 1714
Cdd:cd00200 205 DL---STGKCLGTLRGHENGVNSVAFSPDGYLLAS-GSEDGTIRVWD 247
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
78-350 |
6.43e-18 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 86.23 E-value: 6.43e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 78 LQGHcEGELWALALHPKKPLAVTGSDDRSVRLWSLADHALIAR-CNMEEAVRSVAFSPDGSQLALGMKDGSFIVLRVRDM 156
Cdd:cd00200 5 LKGH-TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTlKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 157 TEVVHIKDRKEVIHEMKFSPDGSYLAVGSNDGPVDVYAVAQrykkiGECSKSL----SFITHIDWSLDSKYLQT--NDGA 230
Cdd:cd00200 84 ECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVET-----GKCLTTLrghtDWVNSVAFSPDGTFVASssQDGT 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 231 GerLFYRMPSGKPLTS----KEEIKGIPW---------------------ASWTCVKGPEVSGIWpkytevtdINSVDAN 285
Cdd:cd00200 159 I--KLWDLRTGKCVATltghTGEVNSVAFspdgekllssssdgtiklwdlSTGKCLGTLRGHENG--------VNSVAFS 228
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462573197 286 YNSSVLVSGDDFGLVKLFKfpcLKRGAKFRKYVGHSAHVTNVRWSHDFQWVLStGGADHSVFQWR 350
Cdd:cd00200 229 PDGYLLASGSEDGTIRVWD---LRTGECVQTLSGHTNSVTSLAWSPDGKRLAS-GSADGTIRIWD 289
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
8-194 |
6.80e-18 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 86.23 E-value: 6.80e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 8 FATGGRDGCIRLWDTD-FKPITkidlreTEQGYKGlSIRSVCW-KADRLLA-GTQDSEIFEVIVRErDKPMLILQGHcEG 84
Cdd:cd00200 108 LSSSSRDKTIKVWDVEtGKCLT------TLRGHTD-WVNSVAFsPDGTFVAsSSQDGTIKLWDLRT-GKCVATLTGH-TG 178
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 85 ELWALALHPKKPLAVTGSDDRSVRLWSLADHALIARCN-MEEAVRSVAFSPDGSQLALGMKDGSFIVLRVRDMTEVVHIK 163
Cdd:cd00200 179 EVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRgHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLS 258
|
170 180 190
....*....|....*....|....*....|.
gi 2462573197 164 DRKEVIHEMKFSPDGSYLAVGSNDGPVDVYA 194
Cdd:cd00200 259 GHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
9-155 |
1.40e-17 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 87.27 E-value: 1.40e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 9 ATGGRDGCIRLWDTDFKpitkiDLRETEQGYKGlSIRSVCWKAD--RLLAGTQDSEI--FEVivrERDKPMLILQGHcEG 84
Cdd:COG2319 262 ASGSADGTVRLWDLATG-----ELLRTLTGHSG-GVNSVAFSPDgkLLASGSDDGTVrlWDL---ATGKLLRTLTGH-TG 331
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462573197 85 ELWALALHPKKPLAVTGSDDRSVRLWSLADHALIARCNM-EEAVRSVAFSPDGSQLALGMKDGSFIVLRVRD 155
Cdd:COG2319 332 AVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGhTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
279-584 |
1.16e-14 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 76.60 E-value: 1.16e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 279 INSVDANYNSSVLVSGDDFGLVKLFKfpcLKRGAKFRKYVGHSAHVTNVRWSHDFQWVLStGGADHSVFQWRFipegvsn 358
Cdd:cd00200 12 VTCVAFSPDGKLLATGSGDGTIKVWD---LETGELLRTLKGHTGPVRDVAASADGTYLAS-GSSDKTIRLWDL------- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 359 gmletapqEGGADSYS-EESDSDLSDVpeldsDIEQEAQI----NYDRQVYKEDLPQLKQQSKEKNHavpflkrekapED 433
Cdd:cd00200 81 --------ETGECVRTlTGHTSYVSSV-----AFSPDGRIlsssSRDKTIKVWDVETGKCLTTLRGH-----------TD 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 434 SLklqfihgyrgydcrNNLFYTQAGEVVYHIAA--VAVVYN-RQQHSQRLYLGHDDDILSLTIHPVKDYVATGqvGRDAA 510
Cdd:cd00200 137 WV--------------NSVAFSPDGTFVASSSQdgTIKLWDlRTGKCVATLTGHTGEVNSVAFSPDGEKLLSS--SSDGT 200
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462573197 511 IHVWDTQTLKCLSLLKGqHQRGVCALDFSADGKCLVSVGLDdfHSIVFWDWKKGEKIATTRGHKDKIFVVKCNP 584
Cdd:cd00200 201 IKLWDLSTGKCLGTLRG-HENGVNSVAFSPDGYLLASGSED--GTIRVWDLRTGECVQTLSGHTNSVTSLAWSP 271
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
1156-1387 |
1.19e-13 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 73.52 E-value: 1.19e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 1156 IVQNLSTGSQSFYLE-HTDDILCLTVNQHPKYrnVVATSQIGTtpsIHIWDAMTKHTLSMLRCfHSKGVNYINFSATGKL 1234
Cdd:cd00200 76 RLWDLETGECVRTLTgHTSYVSSVAFSPDGRI--LSSSSRDKT---IKVWDVETGKCLTTLRG-HTDWVNSVAFSPDGTF 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 1235 LVSVGVDpeHTITVWRWQEGAKVASRGGHLERIFVVEFRPDSDTQFVSVGVKHMKFWTLAGSALLYkkgvigsLGAAKMQ 1314
Cdd:cd00200 150 VASSSQD--GTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLG-------TLRGHEN 220
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462573197 1315 TMLSVAFGANNLTFTGA-INGDVYVWK-DHFLIRLVAKAHTGPVFTMYTTLRDGLIVTGGkerptkEGGAVKLWD 1387
Cdd:cd00200 221 GVNSVAFSPDGYLLASGsEDGTIRVWDlRTGECVQTLSGHTNSVTSLAWSPDGKRLASGS------ADGTIRIWD 289
|
|
| HELP |
pfam03451 |
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm ... |
1108-1159 |
6.90e-13 |
|
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.
Pssm-ID: 460922 Cd Length: 72 Bit Score: 65.27 E-value: 6.90e-13
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 2462573197 1108 KNNITKKKKLVEE-LALDHVFGYRGFDCRNNLHYLNDGaDIIFHTAAAGIVQN 1159
Cdd:pfam03451 20 KDDLDQKKEPPDKkLKLEWVYGYRGKDCRSNLYYLPTG-EIVYFTAAVVVLYD 71
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
798-1024 |
3.48e-12 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 68.90 E-value: 3.48e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 798 KKGGRCCAFSPDGKALAVGLNDGSFLVVNADTVEDMVSFHHRKEMISDIKFSKDtGKYLAVASHDNFVDIYNVLTSKRVG 877
Cdd:cd00200 9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASAD-GTYLASGSSDKTIRLWDLETGECVR 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 878 ICKGASSYITHIDWDSRGKLLqvnSGAREQlffeaprgKRHIIrpseiekieWDTWTcvlgPTCEGIWPAHSDitDVNAA 957
Cdd:cd00200 88 TLTGHTSYVSSVAFSPDGRIL---SSSSRD--------KTIKV---------WDVET----GKCLTTLRGHTD--WVNSV 141
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462573197 958 SLTKDCSLLATGDDFGFVKLFSyPVKGQhaRFKKYVGHSAHVTNVRWlHNDSVLLTVGGADTALMIW 1024
Cdd:cd00200 142 AFSPDGTFVASSSQDGTIKLWD-LRTGK--CVATLTGHTGEVNSVAF-SPDGEKLLSSSSDGTIKLW 204
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
881-1387 |
3.65e-09 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 61.08 E-value: 3.65e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 881 GASSYITHIDWDSRGKLLQVNSGAREQLFFEA-PRGKRHIIRPSEIEKIE-WDtwtcVLGPTCEGIWPAHSDitDVNAAS 958
Cdd:COG2319 54 GAGDLTLLLLDAAAGALLATLLGHTAAVLSVAfSPDGRLLASASADGTVRlWD----LATGLLLRTLTGHTG--AVRSVA 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 959 LTKDCSLLATGDDFGFVKLFSYPVKGQHARFKkyvGHSAHVTNVRWlHNDSVLLTVGGADTALMIWtrefvgtqesklvd 1038
Cdd:COG2319 128 FSPDGKTLASGSADGTVRLWDLATGKLLRTLT---GHSGAVTSVAF-SPDGKLLASGSDDGTVRLW-------------- 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 1039 seesdtdveedggydsdvarekaidyttkiyavsiremegtkphqqlkevsveerppvsraapqpeklqknnitkkkklv 1118
Cdd:COG2319 --------------------------------------------------------------------------------
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 1119 eelaldhvfgyrgfdcrnnlhylndgadiifhtaaagivqNLSTGSQSFYLE-HTDDILCLTVNQHPKYrnVVATSQIGT 1197
Cdd:COG2319 190 ----------------------------------------DLATGKLLRTLTgHTGAVRSVAFSPDGKL--LASGSADGT 227
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 1198 tpsIHIWDAMTKHTLSMLRcFHSKGVNYINFSATGKLLVSVGVDpeHTITVWRWQEGAKVASRGGHLERIFVVEFRPDSD 1277
Cdd:COG2319 228 ---VRLWDLATGKLLRTLT-GHSGSVRSVAFSPDGRLLASGSAD--GTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGK 301
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 1278 TqFVSVGV-KHMKFWTLAGSALLykKGVIGSLGAAkmqtmLSVAFGANNLT-FTGAINGDVYVWK-DHFLIRLVAKAHTG 1354
Cdd:COG2319 302 L-LASGSDdGTVRLWDLATGKLL--RTLTGHTGAV-----RSVAFSPDGKTlASGSDDGTVRLWDlATGELLRTLTGHTG 373
|
490 500 510
....*....|....*....|....*....|....
gi 2462573197 1355 PVFTMyTTLRDG-LIVTGGkerptkEGGAVKLWD 1387
Cdd:COG2319 374 AVTSV-AFSPDGrTLASGS------ADGTVRLWD 400
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
5-111 |
2.91e-08 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 57.34 E-value: 2.91e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 5 EEGFATGGRDGCIRLWDTDFKPITKIdLRETEQGykglsIRSVCWKADRLL--AGTQDS--EIFEVivrERDKPMLILQG 80
Cdd:cd00200 189 GEKLLSSSSDGTIKLWDLSTGKCLGT-LRGHENG-----VNSVAFSPDGYLlaSGSEDGtiRVWDL---RTGECVQTLSG 259
|
90 100 110
....*....|....*....|....*....|.
gi 2462573197 81 HcEGELWALALHPKKPLAVTGSDDRSVRLWS 111
Cdd:cd00200 260 H-TNSVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
8-114 |
3.30e-08 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 58.00 E-value: 3.30e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 8 FATGGRDGCIRLWDtdfkpitkIDLRETEQGYKG--LSIRSVCWKAD--RLLAGTQDSEIfEVIVRERDKPMLILQGHcE 83
Cdd:COG2319 303 LASGSDDGTVRLWD--------LATGKLLRTLTGhtGAVRSVAFSPDgkTLASGSDDGTV-RLWDLATGELLRTLTGH-T 372
|
90 100 110
....*....|....*....|....*....|.
gi 2462573197 84 GELWALALHPKKPLAVTGSDDRSVRLWSLAD 114
Cdd:COG2319 373 GAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
|
|
| YncE |
COG3391 |
DNA-binding beta-propeller fold protein YncE [General function prediction only]; |
1457-1588 |
2.31e-05 |
|
DNA-binding beta-propeller fold protein YncE [General function prediction only];
Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 47.77 E-value: 2.31e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 1457 KDLFISASNDGTARIWDLADKKLLNKVSLGHAARCAAYSPDGEMVAI-GMKNGEFVILLVNSLKVWGKKRDRKSAiQDIR 1535
Cdd:COG3391 80 RRLYVANSGSGRVSVIDLATGKVVATIPVGGGPRGLAVDPDGGRLYVaDSGNGRVSVIDTATGKVVATIPVGAGP-HGIA 158
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 2462573197 1536 ISPDNRFLAVGSSE-HTVDFY----DLTQGTNLNRIgyckDIPSFVIQMDFSADGKYI 1588
Cdd:COG3391 159 VDPDGKRLYVANSGsNTVSVIvsviDTATGKVVATI----PVGGGPVGVAVSPDGRRL 212
|
|
| COG4946 |
COG4946 |
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ... |
126-246 |
4.92e-05 |
|
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];
Pssm-ID: 443973 [Multi-domain] Cd Length: 1072 Bit Score: 48.50 E-value: 4.92e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 126 AVRSVAFSPDGSQLA-LGMKDGSF-IVLR--VRDMTEVVHIKDRKEVIHEMKFSPDGSYLAVGSNDGPVDVYAVA-QRYK 200
Cdd:COG4946 344 RERLPAWSPDGKSIAyFSDASGEYeLYIApaDGSGEPKQLTLGDLGRVFNPVWSPDGKKIAFTDNRGRLWVVDLAsGKVR 423
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 2462573197 201 KIGEcSKSLSFITHIDWSLDSKYL---QTNDGAGERLF-YRMPSGK--PLTS 246
Cdd:COG4946 424 KVDT-DGYGDGISDLAWSPDSKWLaysKPGPNQLSQIFlYDVETGKtvQLTD 474
|
|
| YncE |
COG3391 |
DNA-binding beta-propeller fold protein YncE [General function prediction only]; |
1449-1560 |
1.40e-04 |
|
DNA-binding beta-propeller fold protein YncE [General function prediction only];
Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 45.46 E-value: 1.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 1449 WGLATHPSKD-LFISASNDGTARIWDLADKKLLNKVSLGHAARCAAYSPDGEMVAIGMKNGEFVILLV-----NSLKVWg 1522
Cdd:COG3391 113 RGLAVDPDGGrLYVADSGNGRVSVIDTATGKVVATIPVGAGPHGIAVDPDGKRLYVANSGSNTVSVIVsvidtATGKVV- 191
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 2462573197 1523 KKRDRKSAIQDIRISPDNRFLAV--------GSSEHTVDFYDLTQG 1560
Cdd:COG3391 192 ATIPVGGGPVGVAVSPDGRRLYVanrgsntsNGGSNTVSVIDLATL 237
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
1440-1473 |
2.05e-04 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 40.37 E-value: 2.05e-04
10 20 30
....*....|....*....|....*....|....
gi 2462573197 1440 IDGHmEGEIWGLATHPSKDLFISASNDGTARIWD 1473
Cdd:smart00320 8 LKGH-TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
1440-1473 |
3.24e-04 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 39.64 E-value: 3.24e-04
10 20 30
....*....|....*....|....*....|....
gi 2462573197 1440 IDGHmEGEIWGLATHPSKDLFISASNDGTARIWD 1473
Cdd:pfam00400 7 LEGH-TGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
73-111 |
6.14e-04 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 38.87 E-value: 6.14e-04
10 20 30
....*....|....*....|....*....|....*....
gi 2462573197 73 KPMLILQGHcEGELWALALHPKKPLAVTGSDDRSVRLWS 111
Cdd:pfam00400 2 KLLKTLEGH-TGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
518-560 |
9.71e-04 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 38.45 E-value: 9.71e-04
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 2462573197 518 TLKCLSLLKGqHQRGVCALDFSADGKCLVSVGLDdfHSIVFWD 560
Cdd:smart00320 1 SGELLKTLKG-HTGPVTSVAFSPDGKYLASGSDD--GTIKLWD 40
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
73-111 |
1.43e-03 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 38.06 E-value: 1.43e-03
10 20 30
....*....|....*....|....*....|....*....
gi 2462573197 73 KPMLILQGHcEGELWALALHPKKPLAVTGSDDRSVRLWS 111
Cdd:smart00320 3 ELLKTLKGH-TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| ANAPC4_WD40 |
pfam12894 |
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ... |
1492-1556 |
2.06e-03 |
|
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,
Pssm-ID: 403945 [Multi-domain] Cd Length: 91 Bit Score: 39.18 E-value: 2.06e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462573197 1492 AAYSPDGEMVAIGMKNGEFVILLVNSLKVWGKKRD-RKSAIQDIRISPDNRFLAVGSSEHTVDFYD 1556
Cdd:pfam12894 1 MSWCPTMDLIALATEDGELLLHRLNWQRVWTLSPDkEDLEVTSLAWRPDGKLLAVGYSDGTVRLLD 66
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
1679-1713 |
2.36e-03 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 37.32 E-value: 2.36e-03
10 20 30
....*....|....*....|....*....|....*
gi 2462573197 1679 KRYFGHSAHVTNIRFSYDDKYVVStGGDDCSVFVW 1713
Cdd:pfam00400 5 KTLEGHTGSVTSLAFSPDGKLLAS-GSDDGTVKVW 38
|
|
| YncE |
COG3391 |
DNA-binding beta-propeller fold protein YncE [General function prediction only]; |
97-188 |
3.63e-03 |
|
DNA-binding beta-propeller fold protein YncE [General function prediction only];
Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 40.83 E-value: 3.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 97 LAVTGSDDRSVRLWSLADHALIARCNMEEAVRSVAFSPDGSQL-ALGMKDGSFIVLRVRDMTEVVHIKDRKEViHEMKFS 175
Cdd:COG3391 82 LYVANSGSGRVSVIDLATGKVVATIPVGGGPRGLAVDPDGGRLyVADSGNGRVSVIDTATGKVVATIPVGAGP-HGIAVD 160
|
90
....*....|...
gi 2462573197 176 PDGSYLAVGSNDG 188
Cdd:COG3391 161 PDGKRLYVANSGS 173
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
1674-1713 |
4.38e-03 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 36.52 E-value: 4.38e-03
10 20 30 40
....*....|....*....|....*....|....*....|
gi 2462573197 1674 KFAKHKRYFGHSAHVTNIRFSYDDKYVVStGGDDCSVFVW 1713
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLAS-GSDDGTIKLW 39
|
|
| YncE |
COG3391 |
DNA-binding beta-propeller fold protein YncE [General function prediction only]; |
87-183 |
4.88e-03 |
|
DNA-binding beta-propeller fold protein YncE [General function prediction only];
Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 40.45 E-value: 4.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573197 87 WALALHPK-KPLAVTGSDDRSVRLWSLADHALIARCNMEEAVRSVAFSPDGSQLALGMKDGSFI-----VLRVRDMTEVV 160
Cdd:COG3391 113 RGLAVDPDgGRLYVADSGNGRVSVIDTATGKVVATIPVGAGPHGIAVDPDGKRLYVANSGSNTVsvivsVIDTATGKVVA 192
|
90 100
....*....|....*....|...
gi 2462573197 161 HIkDRKEVIHEMKFSPDGSYLAV 183
Cdd:COG3391 193 TI-PVGGGPVGVAVSPDGRRLYV 214
|
|
| |
