NCBI Conserved Domain Search

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

325-583

1.15e-28

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

Pssm-ID: 442289 [Multi-domain] Cd Length: 277 Bit Score: 115.64 E-value: 1.15e-28

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 325 TGVVMENNTIIVAGEASASKLSrqknKNVEIYryhDRGNQFWEKLctAEF----RELYALGSIHNDLYVIGGQMKIKNQY 400
Cdd:COG3055    16 AAAALLDGKVYVAGGLSGGSAS----NSFEVY---DPATNTWSEL--APLpgppRHHAAAVAQDGKLYVFGGFTGANPSS 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 401 LITNCVDKYSVERDNWKRVSPLPLQLACHAVVTVNNKLYVIGGWTPQMDLPDeepdrlsnkLLQYDPSQDQWSVRAPMKY 480
Cdd:COG3055    87 TPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAW---------VEVYDPATGTWTQLAPLPT 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 481 SKYRFSTAVV-NSEIYVLGGigcvgqdkgqvrkcldvvEIYNPDGDFWREGPPMPSPllslrTNSTNAGAVDGKLYVCGG 559
Cdd:COG3055   158 PRDHLAAAVLpDGKILVIGG------------------RNGSGFSNTWTTLAPLPTA-----RAGHAAAVLGGKILVFGG 214

                         250       260
                  ....*....|....*....|....
gi 2462587650 560 FHGAdrheviSKEILELDPWENQW 583
Cdd:COG3055   215 ESGF------SDEVEAYDPATNTW 232

BTB

smart00225

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...

32-127

5.21e-24

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

Pssm-ID: 197585 [Multi-domain] Cd Length: 97 Bit Score: 96.61 E-value: 5.21e-24

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650   32 DVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVLLNYMYNAALEINNANVQTVAMAAYFM 111
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|....*.
gi 2462587650  112 QMEEVFSVCQKYMMDH 127
Cdd:smart00225  81 QIPGLVELCEEFLLKL 96

BTB

pfam00651

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...

22-124

4.59e-22

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

Pssm-ID: 395526 [Multi-domain] Cd Length: 107 Bit Score: 91.16 E-value: 4.59e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  22 KNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVLLNYMYNAALeINNANV 101
Cdd:pfam00651   2 NELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKL-ISEENV 80

                          90       100
                  ....*....|....*....|...
gi 2462587650 102 QTVAMAAYFMQMEEVFSVCQKYM 124
Cdd:pfam00651  81 DDLLAAADKLQIPSLVDKCEEFL 103

Kelch

Kelch domain;

437-491

6.77e-09

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 51.79 E-value: 6.77e-09

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2462587650  437 KLYVIGGWTPQMDLpdeepdrlsNKLLQYDPSQDQWSVRAPMKYSKYRFSTAVVN 491
Cdd:smart00612   1 KIYVVGGFDGGQRL---------KSVEVYDPETNKWTPLPSMPTPRSGHGVAVIN 46

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

427-479

3.40e-08

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 49.92 E-value: 3.40e-08

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2462587650 427 ACHAVVTVNNKLYVIGGWTPQmdlpdeepdRLSNKLLQYDPSQDQWSVRAPMK 479
Cdd:pfam01344   3 SGAGVVVVGGKIYVIGGFDGN---------QSLNSVEVYDPETNTWSKLPSMP 46

muta_rot_YjhT

TIGR03547

mutatrotase, YjhT family; Members of this protein family contain multiple copies of the ...

363-586

1.11e-06

mutatrotase, YjhT family; Members of this protein family contain multiple copies of the beta-propeller-forming Kelch repeat. All are full-length homologs to YjhT of Escherichia coli, which has been identified as a mutarotase for sialic acid. This protein improves bacterial ability to obtain host sialic acid, and thus serves as a virulence factor. Some bacteria carry what appears to be a cyclically permuted homolog of this protein.

Pssm-ID: 274641 [Multi-domain] Cd Length: 346 Bit Score: 51.17 E-value: 1.11e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 363 NQFWEKLctAEF----RELYALGSIHNDLYVIGGQMKIKNQYLIT--NCVDKYSVERDNWKRV-SPLPLQLACHAVVTVN 435
Cdd:TIGR03547  40 SKGWQKI--ADFpggpRNQAVAAAIDGKLYVFGGIGKANSEGSPQvfDDVYRYDPKKNSWQKLdTRSPVGLLGASGFSLH 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 436 N-KLYVIGGWTPQM------DL----PDEEPDR---------------LSNKLLQYDPSQDQWSVRAPMKYSKyRFSTAV 489
Cdd:TIGR03547 118 NgQAYFTGGVNKNIfdgyfaDLsaadKDSEPKDkliaayfsqppedyfWNKNVLSYDPSTNQWRNLGENPFLG-TAGSAI 196

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 490 V--NSEIYVLGgigcvgqdkGQVRKCLDVVEIYNpdGDF------WREGPPMPSPLLSLRTNSTNA--GAVDGKLYVCGG 559
Cdd:TIGR03547 197 VhkGNKLLLIN---------GEIKPGLRTAEVKQ--YLFtggkleWNKLPPLPPPKSSSQEGLAGAfaGISNGVLLVAGG 265

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 2462587650 560 --FHGADR---------HEVISK----EILELDpwENQWNVV 586
Cdd:TIGR03547 266 anFPGAQEnykngklyaHEGLIKawssEVYALD--NGKWSKV 305

Name

Accession

Description

Interval

E-value

BTB_POZ_KBTBD12

cd18276

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

10-136

2.58e-83

Pssm-ID: 349585 [Multi-domain] Cd Length: 127 Bit Score: 257.04 E-value: 2.58e-83

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  10 KYQHSLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVLLNYM 89
Cdd:cd18276     1 RQKHSLTLLDQLNRMKELAELTDVVLVAEGEKFPCHRLVLAAFSPYFKAMFTCGLMECSQREVVLHDITAESVSIILNYM 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2462587650  90 YNAALEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDASNCLGI 136
Cdd:cd18276    81 YSSDLHLTNSNVQGVATAAFFLQMEDIFSVCQKYMMDHMDASNCLGI 127

BACK_KBTBD12

cd18485

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...

128-227

2.44e-63

Pssm-ID: 350560 [Multi-domain] Cd Length: 100 Bit Score: 203.81 E-value: 2.44e-63

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 128 MDASNCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLNISREESILDLVLRWVNHNKE 207
Cdd:cd18485     1 MDASNCLGIYYFAKQIGAEDLSDRARKYLYQHFTEVCLHEEVLEIEAHQLLTLIKSDDLNVSREESILDLVLRWVNHNRK 80

                          90       100
                  ....*....|....*....|
gi 2462587650 208 LRTVHLVELLKQVRLELVNP 227
Cdd:cd18485    81 SRVQHLVELLKQVRLELVSP 100

PHA03098

kelch-like protein; Provisional

29-586

6.83e-48

kelch-like protein; Provisional

Pssm-ID: 222983 [Multi-domain] Cd Length: 534 Bit Score: 176.11 E-value: 6.83e-48

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  29 EMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLEcnqREVILYdITAESVSVLLNYMYNAALEINNANVQTVAMAA 108
Cdd:PHA03098   10 CDESIIIVNGGGIIKVHKIILSSSSEYFKKMFKNNFKE---NEINLN-IDYDSFNEVIKYIYTGKINITSNNVKDILSIA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 109 YFMQMEEVFSVCQKYMMDHMDASNCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLNI 188
Cdd:PHA03098   86 NYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILSDDKLNV 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 189 SREESILDLVLRWVNHNKELRTVHLVELLKQVRLELVNPSFLRqALRRNTMLLCDADCVdIIQNAFKAIKTPQQHSLNLR 268
Cdd:PHA03098  166 SSEDVVLEIIIKWLTSKKNNKYKDICLILKVLRITFLSEEGIK-KLKRWKLRIKKKKIV-FNKRCIKIIYSKKYNLNKIL 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 269 YGMETTSLLLCIGNNSSGIRSRHRSYgdasfcYDPLSRKTyFISSPKYGEglgtvCTGVVMENNTI-IVAGEASASKLSR 347
Cdd:PHA03098  244 PRSSTFGSIIYIHITMSIFTYNYITN------YSPLSEIN-TIIDIHYVY-----CFGSVVLNNVIyFIGGMNKNNLSVN 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 348 QknknveIYRYHDRGNQfWEKLCTAEF-RELYALGSIHNDLYVIGGqmkIKNQyLITNCVDKYSVERDNWKRVSPLPLQL 426
Cdd:PHA03098  312 S------VVSYDTKTKS-WNKVPELIYpRKNPGVTVFNNRIYVIGG---IYNS-ISLNTVESWKPGESKWREEPPLIFPR 380

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 427 ACHAVVTVNNKLYVIGGWTpqmdlpdeEPDRLSNKLLQYDPSQDQWSVRAPMKYSKYRFSTAVVNSEIYVLGGIGCVGQD 506
Cdd:PHA03098  381 YNPCVVNVNNLIYVIGGIS--------KNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGISYIDNI 452

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 507 KGqvrkcLDVVEIYNPDGDFWREGPPMPSPllslRTNStNAGAVDGKLYVCGGFHgadrHEVISKEILELDPWENQWNVV 586
Cdd:PHA03098  453 KV-----YNIVESYNPVTNKWTELSSLNFP----RINA-SLCIFNNKIYVVGGDK----YEYYINEIEVYDDKTNTWTLF 518

BTB_POZ_KLHL8

cd18238

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

16-135

6.96e-34

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349547 [Multi-domain] Cd Length: 120 Bit Score: 125.09 E-value: 6.96e-34

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  16 NLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVLLNYMYNAALE 95
Cdd:cd18238     1 DSFKVLHQFYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEMAESKQDSITIKDIDEEAVELLVDFAYTGKLT 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2462587650  96 INNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDASNCLG 135
Cdd:cd18238    81 LTVDNVQSLLYAASLLQVEEVAKACCEFMKDHLHPSNCLG 120

BACK

pfam07707

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...

133-235

9.24e-34

Pssm-ID: 462237 [Multi-domain] Cd Length: 103 Bit Score: 124.19 E-value: 9.24e-34

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 133 CLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLNISREESILDLVLRWVNHNKELRTVH 212
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKH 80

                          90       100
                  ....*....|....*....|...
gi 2462587650 213 LVELLKQVRLELVNPSFLRQALR 235
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNLVE 103

BTB_POZ_KLHL26

cd18255

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

13-133

1.85e-32

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349564 [Multi-domain] Cd Length: 121 Bit Score: 121.35 E-value: 1.85e-32

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  13 HSLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVLLNYMYNA 92
Cdd:cd18255     1 HSVTLLQGLNALRAKGQLLDVTLIADGQRFQAHKVVLASCSDYFRAMFTGGMRESSQDEIELKGVSAKGLKHILDFAYTS 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2462587650  93 ALEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDASNC 133
Cdd:cd18255    81 ELTLDLDCIQDVLGAAVHLQMLPVVELCEEFLKSAMSVENC 121

BTB_POZ_KLHL40_KBTBD5

cd18340

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

11-137

3.30e-31

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349649 [Multi-domain] Cd Length: 134 Bit Score: 118.40 E-value: 3.30e-31

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  11 YQHSLnLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVLLNYMY 90
Cdd:cd18340     9 YQQTL-LQDGLKDLLDHNKFVDCVLKIKEKEFPCHRLVLAACSPYFRAMFLSDLEESKKREIVLEDVDPDVMGKILHYIY 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2462587650  91 NAALEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDASNCLGIY 137
Cdd:cd18340    88 TSEIEITEQNVQDIFAAANMFQIPSIFTVCVSFLQKRLCLSNCLAIF 134

BTB_POZ_KBTBD8

cd18274

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

13-136

4.77e-31

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349583 [Multi-domain] Cd Length: 129 Bit Score: 117.78 E-value: 4.77e-31

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  13 HSLNLLNKIKNMKELAEMIDVVLTAE-GEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVLLNYMYN 91
Cdd:cd18274     5 HACSILQQLKAMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMHLVLDYAYT 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2462587650  92 AALEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDASNCLGI 136
Cdd:cd18274    85 SRVTLTEANVQALFTAASIFQIPSLQDQCAQFMISRLDPQNSIGV 129

BACK

smart00875

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...

133-232

1.16e-29

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.

Pssm-ID: 197943 [Multi-domain] Cd Length: 101 Bit Score: 112.82 E-value: 1.16e-29

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  133 CLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLNISREESILDLVLRWVNHNKELRTVH 212
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREH 80

                           90       100
                   ....*....|....*....|
gi 2462587650  213 LVELLKQVRLELVNPSFLRQ 232
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLLE 100

BTB_POZ_KLHL27_IPP

cd18256

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

12-135

7.97e-29

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349565 [Multi-domain] Cd Length: 125 Bit Score: 111.34 E-value: 7.97e-29

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  12 QHSLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVLLNYMYN 91
Cdd:cd18256     2 KHASLILAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFAGGMSESSKDVVQIHGVEPDIFHILLDFIYT 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2462587650  92 AALEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDASNCLG 135
Cdd:cd18256    82 GVVEVTVSNVQELLVAADMLQLTEVVEICCEFLKGQLHPSNCIG 125

NanM

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

325-583

1.15e-28

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

Pssm-ID: 442289 [Multi-domain] Cd Length: 277 Bit Score: 115.64 E-value: 1.15e-28

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 325 TGVVMENNTIIVAGEASASKLSrqknKNVEIYryhDRGNQFWEKLctAEF----RELYALGSIHNDLYVIGGQMKIKNQY 400
Cdd:COG3055    16 AAAALLDGKVYVAGGLSGGSAS----NSFEVY---DPATNTWSEL--APLpgppRHHAAAVAQDGKLYVFGGFTGANPSS 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 401 LITNCVDKYSVERDNWKRVSPLPLQLACHAVVTVNNKLYVIGGWTPQMDLPDeepdrlsnkLLQYDPSQDQWSVRAPMKY 480
Cdd:COG3055    87 TPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAW---------VEVYDPATGTWTQLAPLPT 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 481 SKYRFSTAVV-NSEIYVLGGigcvgqdkgqvrkcldvvEIYNPDGDFWREGPPMPSPllslrTNSTNAGAVDGKLYVCGG 559
Cdd:COG3055   158 PRDHLAAAVLpDGKILVIGG------------------RNGSGFSNTWTTLAPLPTA-----RAGHAAAVLGGKILVFGG 214

                         250       260
                  ....*....|....*....|....
gi 2462587650 560 FHGAdrheviSKEILELDPWENQW 583
Cdd:COG3055   215 ESGF------SDEVEAYDPATNTW 232

BTB_POZ_KLHL40-like

cd18269

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

11-136

2.76e-28

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349578 [Multi-domain] Cd Length: 133 Bit Score: 109.80 E-value: 2.76e-28

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  11 YQHSLnLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVLLNYMY 90
Cdd:cd18269     9 YQQTL-LQDGLKDLLDENKFVDCVLKIGDKEFPCHRLVLAACSPYFRAMFLSDLEESKKKEVVLEDVDPDVMGMILKYLY 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2462587650  91 NAALEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDASNCLGI 136
Cdd:cd18269    88 TSEIDLNDQNVQDIFALASRFQIPSIFTVCVSYLQKRLSLSNCLAI 133

BTB_POZ_KBTBD6_7

cd18273

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

13-137

2.86e-28

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349582 [Multi-domain] Cd Length: 142 Bit Score: 110.30 E-value: 2.86e-28

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  13 HSLNLLNKIKNMKELAEMIDVVLTAEGEK--------FPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSV 84
Cdd:cd18273     9 HARALLAQLKSFYDARLLTDVTIEVNGPGsgpgsgrlFPCNRNVLAAASPYFKSMFTGGLYESKQETVTIHDVDSESMAL 88

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2462587650  85 LLNYMYNAALEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDASNCLGIY 137
Cdd:cd18273    89 IIDYCYTGRVTLSEANVQRLYAAANMLQLEYVREACASFLARRLDLSNCVGIL 141

BACK_KLHL2_like

cd18445

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This ...

131-240

2.13e-27

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This subfamily includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. Both KLHL2 and KLHL3 function as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins.

Pssm-ID: 350520 [Multi-domain] Cd Length: 114 Bit Score: 106.55 E-value: 2.13e-27

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 131 SNCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLNISREESILDLVLRWVNHNKELRT 210
Cdd:cd18445     4 SNCLGIRAFADLHSCTDLLKYAQTYTEQHFSEVVKGEEFLLLSKEQVCELISSDDLTVPSEEKVFEAVMSWVNHDPENRK 83

                          90       100       110
                  ....*....|....*....|....*....|
gi 2462587650 211 VHLVELLKQVRLELVNPSFLRQALRRNTML 240
Cdd:cd18445    84 EHLAELLEHVRLPLLSPEYLVQRVEEEELI 113

BTB_POZ_KLHL12_C3IP1_DKIR

cd18242

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

13-133

3.61e-27

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349551 [Multi-domain] Cd Length: 124 Bit Score: 106.37 E-value: 3.61e-27

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  13 HSLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVLLNYMYNA 92
Cdd:cd18242     4 HAKSILNTMNSLRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFTSEMSEKGKSEVELQGLTASTMEILLDFVYTE 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2462587650  93 ALEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDASNC 133
Cdd:cd18242    84 TVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSNC 124

BTB_POZ_ZBTB_KLHL-like

cd18186

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

32-110

9.36e-27

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349497 [Multi-domain] Cd Length: 82 Bit Score: 103.79 E-value: 9.36e-27

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462587650  32 DVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVLLNYMYNAALEINNANVQTVAMAAYF 110
Cdd:cd18186     3 DVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSSEIELDDVSPEAFEALLDYIYTGELELSEENVEELLAAADK 81

NanM

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

415-587

9.79e-27

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

Pssm-ID: 442289 [Multi-domain] Cd Length: 277 Bit Score: 109.86 E-value: 9.79e-27

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 415 NWKRVSPLPLQLACHAVVTVNNKLYVIGGWTpqmdlpdeePDRLSNKLLQYDPSQDQWSVRAPMKYSKYRFS-TAVVNSE 493
Cdd:COG3055     2 TWSSLPDLPTPRSEAAAALLDGKVYVAGGLS---------GGSASNSFEVYDPATNTWSELAPLPGPPRHHAaAVAQDGK 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 494 IYVLGGigcvGQDKGQVRKCLDVVEIYNPDGDFWREGPPMPSPllslRTNSTnAGAVDGKLYVCGGFHGADRheviSKEI 573
Cdd:COG3055    73 LYVFGG----FTGANPSSTPLNDVYVYDPATNTWTKLAPMPTP----RGGAT-ALLLDGKIYVVGGWDDGGN----VAWV 139

                         170
                  ....*....|....
gi 2462587650 574 LELDPWENQWNVVA 587
Cdd:COG3055   140 EVYDPATGTWTQLA 153

BTB_POZ_KLHL7

cd18237

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

11-135

9.94e-27

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349546 [Multi-domain] Cd Length: 126 Bit Score: 105.26 E-value: 9.94e-27

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  11 YQHSLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVLLNYMY 90
Cdd:cd18237     2 AKLLADFMGVMNNMRKQKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSNMTESKSSEVELKDAEPDIIELLVEFAY 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2462587650  91 NAALEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDASNCLG 135
Cdd:cd18237    82 TARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQLDASNCLG 126

BTB_POZ_KLHL1-like

cd18234

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

32-134

2.40e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349543 [Multi-domain] Cd Length: 105 Bit Score: 103.60 E-value: 2.40e-26

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  32 DVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVLLNYMYNAALEINNANVQTVAMAAYFM 111
Cdd:cd18234     3 DVILIAGDRRIPAHRLVLSAVSDYFAAMFTNDVREATEEEIKLKDVDPDALWTLVQYCYTGRLELKEDNVESLLATACLL 82

                          90       100
                  ....*....|....*....|...
gi 2462587650 112 QMEEVFSVCQKYMMDHMDASNCL 134
Cdd:cd18234    83 QLSEVVEACCGFLMKQLHPSNCL 105

BACK_KLHL29_KBTBD9

cd18468

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also ...

129-230

4.25e-26

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also termed Kelch repeat and BTB domain-containing protein 9 (KBTBD9), belongs to the KLHL family. Its function remains unclear. A nuclear receptor subfamily 5, group A, member 2 (NR5A2)-Kelch-like family member 29 (KLHL29) fusion transcript may participate in the origin or progression of some colon cancers.

Pssm-ID: 350543 [Multi-domain] Cd Length: 102 Bit Score: 102.49 E-value: 4.25e-26

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 129 DASNCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLNISREESILDLVLRWVNHNKEL 208
Cdd:cd18468     1 TPSNCLGIWALAEALQCTELHNMAKAYALQNFPDVARQEEILSISKDDIVEYLSHDSLNTKAEELVFETAIKWLKKDPKN 80

                          90       100
                  ....*....|....*....|..
gi 2462587650 209 RTVHLVELLKQVRLELVNPSFL 230
Cdd:cd18468    81 RKQHIAELLAVVRLPFIHPSYL 102

BTB_POZ_KBTBD2_BKLHD1

cd18270

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

12-134

1.01e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349579 [Multi-domain] Cd Length: 133 Bit Score: 102.77 E-value: 1.01e-25

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  12 QHSLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVLLNYMYN 91
Cdd:cd18270     8 EYAVSLLEQLKFFYEQQLLTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLRNVDAATLQIIITYAYT 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2462587650  92 AALEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDASNCL 134
Cdd:cd18270    88 GNLAINDSTVEQLYETACFLQVEDVLQRCREYLIKKINAENCV 130

BACK_KLHL2_Mayven

cd18512

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also ...

131-255

1.17e-25

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation.

Pssm-ID: 350587 [Multi-domain] Cd Length: 130 Bit Score: 102.42 E-value: 1.17e-25

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 131 SNCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLNISREESILDLVLRWVNHNKELRT 210
Cdd:cd18512     4 TNCLGIRAFADMHACTELLNQANTYAEQHFSDVVLSEEFLNLGIEQVCSLIASDKLTISSEEKVFEAVIAWVNHDKEVRQ 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2462587650 211 VHLVELLKQVRLELVNPSFLRQALRRNTMLLCDADCVDIIQNAFK 255
Cdd:cd18512    84 EHMAHLMEHVRLPLLSREYLVQRVEEETLVKNSSACKDYLIEAMK 128

BTB_POZ_KLHL18

cd18247

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

14-126

1.51e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349556 [Multi-domain] Cd Length: 116 Bit Score: 101.59 E-value: 1.51e-25

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  14 SLNLLNKIKNMKELAemiDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVLLNYMYNAA 93
Cdd:cd18247     6 GFPVMEEIRRQGKLC---DVTLKVGDQKFSAHRIVLAATIPYFHAMFTHDMVESKQDEITMQGIEPSALEALINFAYSGR 82

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2462587650  94 LEINNANVQTVAMAAYFMQMEEVFSVCQKYMMD 126
Cdd:cd18247    83 IAIDTSNVQSLLVGASFLQLQSVKDACCEFLKE 115

BTB_POZ_KLHL21

cd18250

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

13-133

1.73e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349559 [Multi-domain] Cd Length: 124 Bit Score: 101.77 E-value: 1.73e-25

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  13 HSLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVLLNYMYNA 92
Cdd:cd18250     4 HALHLLRGLSELRAERKFFDVTLCAGGREFPCHRTVLAAASSYFRAMFAGELRESRADRVVLHGVSAEILGLLLDFSYTG 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2462587650  93 ALEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDASNC 133
Cdd:cd18250    84 RVTVTQDNVEALLRAADLFQFPSVKEACCAYLQQRLDVSNC 124

BTB_POZ_KLHL35

cd18265

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

13-135

5.55e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349574 [Multi-domain] Cd Length: 128 Bit Score: 100.23 E-value: 5.55e-25

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  13 HSLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVLLNYMYNA 92
Cdd:cd18265     6 HAERILQVLNAYRRSGTFTDVVLLVDGKDFPCHRATLSANSAYFRAMFGGHLKESRQAVVEIQKVSAAAMEVLLDYMYGG 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2462587650  93 ALEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDASNCLG 135
Cdd:cd18265    86 GLRIQEDNVESVLEASDLLQVSKLREACVRFLEGQLHPCNCLG 128

BTB_POZ_KLHL20_KLEIP

cd18249

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

12-135

6.00e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349558 [Multi-domain] Cd Length: 128 Bit Score: 100.22 E-value: 6.00e-25

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  12 QHSLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVLLNYMYN 91
Cdd:cd18249     5 KHPRQTLEAINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVTIRDIDERAMELLIDFAYT 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2462587650  92 AALEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDASNCLG 135
Cdd:cd18249    85 SQITVEEGNVQTLLPAACLLQLAEIQEVCCEFLKRQLDPSNCLG 128

BACK_KLHL18

cd18457

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as ...

132-231

1.42e-24

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A.

Pssm-ID: 350532 [Multi-domain] Cd Length: 107 Bit Score: 98.53 E-value: 1.42e-24

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 132 NCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLNISREESILDLVLRWVNHNKELRTV 211
Cdd:cd18457     5 NCLGIRQFAETMMCSSLVDAANKYIQQHFIEVSKSEEFLALSKEEVLEILSRDELNVKSEEQVFEAALAWVKYDRENREE 84

                          90       100
                  ....*....|....*....|
gi 2462587650 212 HLVELLKQVRLELVNPSFLR 231
Cdd:cd18457    85 YLPELLSKVRLPLLRPQFLT 104

BTB_POZ_KLHL2-like

cd18235

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

12-120

1.61e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349544 [Multi-domain] Cd Length: 121 Bit Score: 98.65 E-value: 1.61e-24

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  12 QHSLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVLLNYMYN 91
Cdd:cd18235     3 QHTQKAFDVMNELRKQNLLCDVILVADGVEIPAHRVVLASCSPYFHAMFTGDLSESRANRVTLQDVDGKALLLLIDYVYT 82

                          90       100
                  ....*....|....*....|....*....
gi 2462587650  92 AALEINNANVQTVAMAAYFMQMEEVFSVC 120
Cdd:cd18235    83 AEIQVTEENVQVLLPAANLLQLTDVRDAC 111

BTB_POZ_KLHL30

cd18259

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

13-135

2.46e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349568 [Multi-domain] Cd Length: 137 Bit Score: 98.75 E-value: 2.46e-24

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  13 HSLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVLLNYMYNA 92
Cdd:cd18259    15 HPQSILDGLQTLRSNPKLSDVTLLVGGREFPCHRSVLALCSHYFNAMFTGDFVESISARVEIKDVDPAVMESLIDFAYTG 94

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2462587650  93 ALEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDASNCLG 135
Cdd:cd18259    95 KLTINQGNVEALIRTSNRLQFPTVRKVCSRYLQQQIDATNCLG 137

BTB_POZ_KLHL38

cd18268

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

14-136

2.66e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349577 [Multi-domain] Cd Length: 129 Bit Score: 98.32 E-value: 2.66e-24

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  14 SLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVLLNYMYNAA 93
Cdd:cd18268     7 SSELLRQLNSLRQERILTDVILCTGDKEIPCHRNVLASSSPYFRAMFCNNFRESSQAKVDLKGIDSDVLDQIVDYVYTGE 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2462587650  94 LEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDASNCLGI 136
Cdd:cd18268    87 ILITRDNVLPLMEAASMLQYPKLFEACSLYLQDQLTPENCLSM 129

BTB_POZ_NS1BP

cd18306

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

13-136

2.74e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349615 [Multi-domain] Cd Length: 124 Bit Score: 98.10 E-value: 2.74e-24

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  13 HSLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVLLNYMYNA 92
Cdd:cd18306     1 HPESVLAKLNALRKNRQFCDVILQVGGHEIPAHRAVLACASPYLFELFSSDSDGESILTVKLDGLDPDAVEVLVNYAYTS 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2462587650  93 ALEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDASNCLGI 136
Cdd:cd18306    81 RLEVPADLVKSVYSAAKKLKMDRVKKACGDFLLEKLTPQNCIGI 124

BACK_KLHL12

cd18452

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also ...

128-255

2.88e-24

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also termed CUL3-interacting protein 1 (C3IP1), or DKIR, is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport.

Pssm-ID: 350527 [Multi-domain] Cd Length: 136 Bit Score: 98.62 E-value: 2.88e-24

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 128 MDASNCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLNISREESILDLVLRWVNHNKE 207
Cdd:cd18452     1 LDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFMLLSQEEVEKLIKSDEIQVDSEEPVFEAVLNWVKHDKE 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2462587650 208 LRTVHLVELLKQVRLELVNPSFLRQALRRNTMLLCDADCVDIIQNAFK 255
Cdd:cd18452    81 EREDYLPELLQYVRLPLLSPRYITDVVDAEPLIRCSLECRDLVDEAKK 128

BTB

smart00225

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...

32-127

5.21e-24

Pssm-ID: 197585 [Multi-domain] Cd Length: 97 Bit Score: 96.61 E-value: 5.21e-24

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650   32 DVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVLLNYMYNAALEINNANVQTVAMAAYFM 111
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|....*.
gi 2462587650  112 QMEEVFSVCQKYMMDH 127
Cdd:smart00225  81 QIPGLVELCEEFLLKL 96

BACK_KLHL3

cd18513

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as ...

131-255

1.47e-23

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as a substrate adapter in Cullin3 (Cul3) E3 ubiquitin ligase complexes. It is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation.

Pssm-ID: 350588 [Multi-domain] Cd Length: 130 Bit Score: 96.29 E-value: 1.47e-23

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 131 SNCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLNISREESILDLVLRWVNHNKELRT 210
Cdd:cd18513     4 TNCLGIRAFADVHTCTELLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWIKYDKEARL 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2462587650 211 VHLVELLKQVRLELVNPSFLRQALRRNTMLLCDADCVDIIQNAFK 255
Cdd:cd18513    84 EHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMK 128

BTB_POZ_KLHL4

cd18336

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

13-136

1.75e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349645 [Multi-domain] Cd Length: 126 Bit Score: 95.88 E-value: 1.75e-23

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  13 HSLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVLLNYMYNA 92
Cdd:cd18336     2 HAEQTFRKMENYLQHKQLCDVLLIAGNLKIPAHRLVLSAVSDYFAAMFTNDVREAKQEEIKMEGVDPDALKALVHYAYTG 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2462587650  93 ALEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDASNCLGI 136
Cdd:cd18336    82 VLELKEDTIESLLAAACLLQLSQVIDVCCNFLMKQLHPSNCLGI 125

BTB_POZ_KLHL24_KRIP6

cd18253

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

13-133

1.37e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349562 [Multi-domain] Cd Length: 121 Bit Score: 93.36 E-value: 1.37e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  13 HSLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVLLNYMYNA 92
Cdd:cd18253     1 HSESILQVFNEFRDSRLFTDVIICVEGREFPCHRAILSACSSYFRAMFCNDHRESREMLVEINGILAEAMDCFLQYVYTG 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2462587650  93 ALEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDASNC 133
Cdd:cd18253    81 KVKITTENVQYLFETSSLFQISPLRDACAKFLEEQLDPCNC 121

BACK_KLHL8

cd18448

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a ...

127-222

3.90e-22

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.

Pssm-ID: 350523 [Multi-domain] Cd Length: 97 Bit Score: 91.21 E-value: 3.90e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 127 HMDASNCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLNISREESILDLVLRWVNHNK 206
Cdd:cd18448     1 HLHPSNCLGVRTFAEQHNRVDLMKMADKYACDHFNEVVECEEFVSISAQHLEKLISSSDLNVESESQVYEAVMKWVKHDP 80

                          90
                  ....*....|....*.
gi 2462587650 207 ELRTVHLVELLKQVRL 222
Cdd:cd18448    81 QHRKRHLDDLLSQVRL 96

BTB

pfam00651

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...

22-124

4.59e-22

Pssm-ID: 395526 [Multi-domain] Cd Length: 107 Bit Score: 91.16 E-value: 4.59e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  22 KNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVLLNYMYNAALeINNANV 101
Cdd:pfam00651   2 NELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKL-ISEENV 80

                          90       100
                  ....*....|....*....|...
gi 2462587650 102 QTVAMAAYFMQMEEVFSVCQKYM 124
Cdd:pfam00651  81 DDLLAAADKLQIPSLVDKCEEFL 103

BACK_KLHL5

cd18511

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares ...

131-230

4.61e-22

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. It is abundantly expressed in ovary, adrenal gland, and thymus.

Pssm-ID: 350586 [Multi-domain] Cd Length: 106 Bit Score: 91.28 E-value: 4.61e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 131 SNCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLNISREESILDLVLRWVNHNKELRT 210
Cdd:cd18511     5 SNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFLLLPASEIAKLLASDDMNIPNEETILNALLSWVRHDVEQRR 84

                          90       100
                  ....*....|....*....|
gi 2462587650 211 VHLVELLKQVRLELVNPSFL 230
Cdd:cd18511    85 KDLSKLLAYIRLPLLAPQFL 104

BTB_POZ_KLHL41_KBTBD10

cd18341

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

11-136

1.77e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349650 [Multi-domain] Cd Length: 133 Bit Score: 90.68 E-value: 1.77e-21

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  11 YQHSLnLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVLLNYMY 90
Cdd:cd18341     9 YQSTL-LQDGLKELLDENKFVDCTLKAGDKSLPCHRLILAACSPYFREYFLSEESEEKKKEVVLDNVDPNIMDMILKYLY 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2462587650  91 NAALEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDASNCLGI 136
Cdd:cd18341    88 SAEIDLNDGNVQDIFALASRFQIPSVFTVCVTYLQKRLSPANCLAI 133

BACK_KLHL1_like

cd18444

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; ...

131-230

2.19e-21

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This subfamily contains Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. Members of this subfamily contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels.

Pssm-ID: 350519 [Multi-domain] Cd Length: 106 Bit Score: 89.31 E-value: 2.19e-21

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 131 SNCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLNISREESILDLVLRWVNHNKELRT 210
Cdd:cd18444     5 SNCLGIRSFADAQGCTDLLKVAHNYTMEHFMEVIQNQEFLLLPAEEVAKLLASDDLNVPSEETIFHALLLWVKHDLPERK 84

                          90       100
                  ....*....|....*....|
gi 2462587650 211 VHLVELLKQVRLELVNPSFL 230
Cdd:cd18444    85 KHLAKLLALIRLPLLTPQFL 104

BTB_POZ_KLHL19_KEAP1

cd18248

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

20-129

3.39e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349557 [Multi-domain] Cd Length: 124 Bit Score: 89.36 E-value: 3.39e-21

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  20 KIKNMKELAEMI-DVVLTAEG----EKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVLLNYMYNAAL 94
Cdd:cd18248    10 QIMNELRLSQQLcDVTLKVKYqdpkEEFMAHKVVLASSSPYFKAMFTSGLRECGMEVVPIEGVHPCVMSRLIEFAYTASI 89

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2462587650  95 EINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMD 129
Cdd:cd18248    90 SVGEKCVLHVLPGAVMYQMDSVVKACCDFLEQQLD 124

BACK_KLHL24

cd18463

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also ...

128-204

4.69e-21

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6), or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation.

Pssm-ID: 350538 [Multi-domain] Cd Length: 78 Bit Score: 87.45 E-value: 4.69e-21

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462587650 128 MDASNCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLNISREESILDLVLRWVNH 204
Cdd:cd18463     2 LDPCNCLGIQKFADTHSLKQLFEKCKKFALENFVEVSQHEEFLELCKDELIEYISNDELVVPKEEEVFEAVMRWVYH 78

BACK_KLHL19_KEAP1

cd18458

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); ...

128-217

7.18e-21

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also termed cytosolic inhibitor of Nrf2 (INrf2), or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression.

Pssm-ID: 350533 [Multi-domain] Cd Length: 91 Bit Score: 87.35 E-value: 7.18e-21

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 128 MDASNCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLNISREESILDLVLRWVNHNKE 207
Cdd:cd18458     2 LDPSNCIGIANFAEQHGCTELHKKAREYIYMHFSEVSQSEEFFNLSPCQLVALISRDELNVRCESEVYNAVIRWVKYDEE 81

                          90
                  ....*....|
gi 2462587650 208 LRTVHLVELL 217
Cdd:cd18458    82 NRRQYLEALL 91

BTB_POZ_KLHL22

cd18251

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

12-132

9.62e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349560 [Multi-domain] Cd Length: 125 Bit Score: 88.34 E-value: 9.62e-21

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  12 QHSLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVLLNYMYN 91
Cdd:cd18251     5 AHSQALLDGLVALRDSGILFDVVLVVEGKPIEAHRILLAASCDYFRGMFAGGLREMQQTEVLIHGVSYNAMCKILDFIYT 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2462587650  92 AALEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDASN 132
Cdd:cd18251    85 SELELSLDNVQETLTAACQLQIPEVIGFCCDFLMSWVDNEN 125

BTB_POZ_KLHL23

cd18252

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

13-135

1.55e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349561 [Multi-domain] Cd Length: 127 Bit Score: 87.57 E-value: 1.55e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  13 HSLNLLNKIKNMKELAEMIDVVL-TAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVLLNYMYN 91
Cdd:cd18252     4 HPADFLDAFRTFYLDGLFTDITLqCASGQIFHCHKAALAACSSYFKVMFTADMKEKSNNVIKLSGIDHDILEALVNYVYT 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2462587650  92 AALEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDASNCLG 135
Cdd:cd18252    84 SQICITERNVQSLLEAADLLQFISVKKACEQFLVRHLDIDNCLG 127

BTB_POZ_KLHL37_ENC1

cd18267

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

10-136

1.56e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349576 [Multi-domain] Cd Length: 147 Bit Score: 88.51 E-value: 1.56e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  10 KYQHSLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYD-ITAESVSVLLNY 88
Cdd:cd18267    20 KSSYADSVLTHLNLLRQQRLFTDVLLHAGNRSFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFHDsIHPEVLELLLDY 99

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2462587650  89 MYNAALEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDASNCLGI 136
Cdd:cd18267   100 AYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCLGM 147

BTB_POZ_KLHL25

cd18254

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

10-135

1.70e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349563 [Multi-domain] Cd Length: 128 Bit Score: 87.76 E-value: 1.70e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  10 KYQHSLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYD-ITAESVSVLLNY 88
Cdd:cd18254     2 KPSHPDCVLTHLNTLRKQCMFTDVTLWAGNRSFPCHRAVLAACSRYFEAMFSNGLRESLDSTVNFHDsLHPEVLELLLDF 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2462587650  89 MYNAALEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDASNCLG 135
Cdd:cd18254    82 AYSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCLG 128

BTB_POZ_KLHL6

cd18236

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

14-135

2.29e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349545 [Multi-domain] Cd Length: 129 Bit Score: 87.21 E-value: 2.29e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  14 SLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVLLNYMYNAA 93
Cdd:cd18236     8 SLVLQNGLENLRLENSLTDVILCVDSQEFSCHRVVLAAASNYFRAMFCNDLKEKYEEKIIIKGVDAETMQILLDYTYTSK 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2462587650  94 LEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDASNCLG 135
Cdd:cd18236    88 VLITKQNVQRVLEAASLFQFLRMVDACASFLTEALHPENCVG 129

BACK_KLHL30

cd18469

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs ...

128-225

4.25e-20

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs to the KLHL family. Its function remains unclear. Differential expression of the KLHL30 gene has been observed in glioblastoma multiforme versus normal brain.

Pssm-ID: 350544 [Multi-domain] Cd Length: 104 Bit Score: 85.58 E-value: 4.25e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 128 MDASNCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLNISREESILDLVLRWVNHNKE 207
Cdd:cd18469     3 IDATNCLGICEFGETHGCPEVAAKAWSFLLENFEAVSQEEEFLQLEKERLVACLGDDLLQVRDEQSRLEAVLRWVGHDPQ 82

                          90
                  ....*....|....*...
gi 2462587650 208 LRTVHLVELLKQVRLELV 225
Cdd:cd18469    83 ARAAHLPELLSLVHLSLL 100

BTB_POZ_KLHL28_BTBD5

cd18257

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

13-130

6.27e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349566 [Multi-domain] Cd Length: 118 Bit Score: 85.67 E-value: 6.27e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  13 HSLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVLLNYMYNA 92
Cdd:cd18257     1 HSEQLLQGLNLLRQHHELCDVVLRVGDVKIHAHKVVLASCSPYFKAMFTGNLSEKENSEVEFQCIDETALQAIVEYAYTG 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2462587650  93 ALEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDA 130
Cdd:cd18257    81 TVFISQATVESLLPAANLLQIKLVLKECCDFLESQLDP 118

BTB_POZ_KBTBD3_BKLHD3

cd18271

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

13-136

1.19e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349580 [Multi-domain] Cd Length: 130 Bit Score: 85.27 E-value: 1.19e-19

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  13 HSLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVLLNYMYNA 92
Cdd:cd18271     7 HGQQILSVLQNFREQNAFFDFNIIVKDETIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTISNLSPKAVKAFLDYAYTG 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2462587650  93 ALEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDASNCLGI 136
Cdd:cd18271    87 KAEITDDNVEMFFQMSSFLQVSLLSKACSDFLIKSIDLTNCLQL 130

BTB_POZ_BTBD9

cd18287

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

12-90

4.06e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349596 [Multi-domain] Cd Length: 119 Bit Score: 83.44 E-value: 4.06e-19

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462587650  12 QHSLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVLLNYMY 90
Cdd:cd18287     4 DHVHFLSEDIGALFLNEEYSDVTFVVEEKRFPAHRVILAARSEYFRALLYGGMRESQQSEIELKDTNAEAFKALLKYIY 82

BTB_POZ_KLHL5

cd18337

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

13-136

1.07e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It is abundantly expressed in the ovary, adrenal gland, and thymus. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349646 [Multi-domain] Cd Length: 130 Bit Score: 82.42 E-value: 1.07e-18

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  13 HSLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVLLNYMYNA 92
Cdd:cd18337     6 HAEQTFKKMENYLRHKQLCDVVLVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREAKQEEIKMEGVEPNALWALVQYAYTG 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2462587650  93 ALEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDASNCLGI 136
Cdd:cd18337    86 RLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGI 129

BTB_POZ_KLHL1

cd18335

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

12-136

1.25e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349644 [Multi-domain] Cd Length: 126 Bit Score: 82.40 E-value: 1.25e-18

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  12 QHSLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVLLNYMYN 91
Cdd:cd18335     1 HHAEQTFRKMESYLKQQQLCDVILIAGNRKIPAHRLVLSAVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYT 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2462587650  92 AALEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDASNCLGI 136
Cdd:cd18335    81 GCLELKEDTIENLLAAACLLQLSQVVEVCCHFLMKLLHPSNCLGI 125

BACK_KBTBD3

cd18480

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...

128-209

2.11e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also termed BTB and kelch domain-containing protein 3 (BKLHD3), is a BTB-Kelch family protein. Its function remains unclear.

Pssm-ID: 350555 [Multi-domain] Cd Length: 82 Bit Score: 80.06 E-value: 2.11e-18

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 128 MDASNCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLNISREESILDLVLRWVNHNKE 207
Cdd:cd18480     1 LDLSNCLQLLSFAESYGSTRLLDHALEFVMQHFSLLSQSQEFLELNFEVLEKILEADELNVPDEEAVLKAVLRWTKHDLE 80


                  ..
gi 2462587650 208 LR 209
Cdd:cd18480    81 AR 82

BTB_POZ_KLHL3

cd18339

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

22-128

4.23e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349648 [Multi-domain] Cd Length: 121 Bit Score: 80.54 E-value: 4.23e-18

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  22 KNMKELAE---MIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVLLNYMYNAALEINN 98
Cdd:cd18339    10 KVMNELRSkqlLCDVTIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQTLSKLIDYIYTAEIEVTE 89

                          90       100       110
                  ....*....|....*....|....*....|
gi 2462587650  99 ANVQTVAMAAYFMQMEEVFSVCQKYMMDHM 128
Cdd:cd18339    90 ENVQVLLPAASLLQLMDVRQNCCDFLQSQL 119

BACK_KLHL17

cd18456

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also ...

128-229

7.28e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also termed actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GluR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in the actin-based neuronal function.

Pssm-ID: 350531 [Multi-domain] Cd Length: 102 Bit Score: 79.27 E-value: 7.28e-18

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 128 MDASNCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLNISREESILDLVLRWVNHNKE 207
Cdd:cd18456     1 LDPSNCLGIRGFADTHSCSDLLKSAHKYVLQHFVEVSKTEEFMLLPLKQVLDLISSDSLNVPSEEEVYRAVLSWVKHDVD 80

                          90       100
                  ....*....|....*....|..
gi 2462587650 208 LRTVHLVELLKQVRLELVNPSF 229
Cdd:cd18456    81 GRRQHVPRLMKCVRLPLLSRDF 102

BTB_POZ_KLHL17_actinfilin

cd18246

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

8-129

1.05e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349555 [Multi-domain] Cd Length: 139 Bit Score: 80.07 E-value: 1.05e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650   8 KEKYQHSLNLLNKiknMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVLLN 87
Cdd:cd18246    20 KRHYHDAFVSMNR---MRQRGLLCDIVLHVGTKEIKAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQALEQLVQ 96

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2462587650  88 YMYNAALEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMD 129
Cdd:cd18246    97 YAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLD 138

BTB_POZ_KLHL36

cd18266

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

13-134

1.36e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349575 [Multi-domain] Cd Length: 135 Bit Score: 79.55 E-value: 1.36e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  13 HSLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVLLNYMYNA 92
Cdd:cd18266     8 HSNLVLQGLNEQRQRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAHQKEVELVGASYIGLKAVIDFLYSS 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2462587650  93 ALEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDASNCL 134
Cdd:cd18266    88 ELPLDGGNIDYVLETAHLLQIWKVVDFCCEYLENEVSEENYL 129

BACK_KEL_like

cd18508

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch ...

129-205

1.57e-17

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch protein (KEL) and similar proteins; KEL, also termed kelch short protein, is a component of ring canals that regulates the flow of cytoplasm between cells. It binds actin and may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis.

Pssm-ID: 350583 [Multi-domain] Cd Length: 77 Bit Score: 77.45 E-value: 1.57e-17

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462587650 129 DASNCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLNISREESILDLVLRWVNHN 205
Cdd:cd18508     1 DATNCLGIHEFADAHSCVELEEAAQNYIYQHFNEVIQGEEFLSLDHESLTELISSDRLNVPSEERVYEAAVAWLKHD 77

BACK_KLHL6

cd18446

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a ...

132-230

1.57e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation.

Pssm-ID: 350521 [Multi-domain] Cd Length: 108 Bit Score: 78.28 E-value: 1.57e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 132 NCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLNISREESILDLVLRWVNHNKELRTV 211
Cdd:cd18446     5 NCVGILRLADAHSLESLKKQVQNYIIQNFSQVLNHEEFLELPVDILCHILKSDDLYVTEEEQVFETVMRWVRYKESERLP 84

                          90
                  ....*....|....*....
gi 2462587650 212 HLVELLKQVRLELVNPSFL 230
Cdd:cd18446    85 LLPRVLENVRLPLLDPWYF 103

BTB_POZ_ZBTB7A

cd18326

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

12-120

1.99e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349635 [Multi-domain] Cd Length: 120 Bit Score: 78.44 E-value: 1.99e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  12 QHSLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLeCNQREVILYD-ITAESVSVLLNYMY 90
Cdd:cd18326     7 DHSSDILSSLNEQRTQGLLCDVVILVEGREFPTHRSVLAACSQYFKKLFTSGAV-VDQQNVYEIDfVSAEALTALLDFAY 85

                          90       100       110
                  ....*....|....*....|....*....|
gi 2462587650  91 NAALEINNANVQTVAMAAYFMQMEEVFSVC 120
Cdd:cd18326    86 TATLTVSTSNVGDILSAARLLEIPAVSHVC 115

BTB_POZ_KLHL10

cd18240

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

13-133

2.50e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349549 [Multi-domain] Cd Length: 120 Bit Score: 78.14 E-value: 2.50e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  13 HSLNLLNKIKNMKELAemiDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVLLNYMYNA 92
Cdd:cd18240     3 MACNVFNELRLEGKLC---DVVIRVNGVEFPAHRNILCACSPYFRALFTNGWNETEKKVYKIPGVSPEMMELIIEYAYTR 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2462587650  93 ALEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDASNC 133
Cdd:cd18240    80 TVPITAENVEELLPAADQFNIMGIVKACCDFLEDQLCPENC 120

BACK_KLHL27_IPP

cd18466

BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide ...

128-230

2.63e-17

BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also termed Kelch-like protein 27 (KLHL27), is an actin-binding protein that may play a role in organizing the actin cytoskeleton.

Pssm-ID: 350541 [Multi-domain] Cd Length: 103 Bit Score: 77.52 E-value: 2.63e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 128 MDASNCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLNISREESILDLVLRWVNHNKE 207
Cdd:cd18466     1 IDPANCIGIFQFSEQIACHDLLEFTENYIHVHFLEVQSGEEFLGLTKDQLVKILRSEELSIEDEYQVFTAAMEWILKDVG 80

                          90       100
                  ....*....|....*....|...
gi 2462587650 208 LRTVHLVELLKQVRLELVNPSFL 230
Cdd:cd18466    81 KRKKHVVEVLEPVRFPLLPPQRL 103

BACK_KBTBD8

cd18483

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...

128-222

2.92e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor for a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralogue TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome.

Pssm-ID: 350558 [Multi-domain] Cd Length: 97 Bit Score: 77.21 E-value: 2.92e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 128 MDASNCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLNISREESILDLVLRWVNHNKE 207
Cdd:cd18483     1 LDPQNSIGVFIFADHYGHQELKERSQDYIRKKFLSVTKEQEFLHLTKDQLISILNSDDLNVEKEEHVYESIIHWFEHEQS 80

                          90
                  ....*....|....*.
gi 2462587650 208 LRTVHLVELL-KQVRL 222
Cdd:cd18483    81 KREMHLPEIFaKCIRM 96

NanM

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

293-499

3.46e-17

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

Pssm-ID: 442289 [Multi-domain] Cd Length: 277 Bit Score: 82.13 E-value: 3.46e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 293 SYGDASFCYDPlSRKTYFISSPKYGEGLGTvcTGVVMENNTIIVAGEASASKLSRQKNKNVEIYryhDRGNQFWEKLCT- 371
Cdd:COG3055    35 SASNSFEVYDP-ATNTWSELAPLPGPPRHH--AAAVAQDGKLYVFGGFTGANPSSTPLNDVYVY---DPATNTWTKLAPm 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 372 AEFRELYALGSIHNDLYVIGGQMKIKNqyliTNCVDKYSVERDNWKRVSPLPLQLACHAVVTV-NNKLYVIGG------- 443
Cdd:COG3055   109 PTPRGGATALLLDGKIYVVGGWDDGGN----VAWVEVYDPATGTWTQLAPLPTPRDHLAAAVLpDGKILVIGGrngsgfs 184

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462587650 444 --WTPQMDLPDEE-----------------PDRLSNKLLQYDPSQDQWSVRAPMKYSKYRFSTAVVNSEIYVLGG 499
Cdd:COG3055   185 ntWTTLAPLPTARaghaaavlggkilvfggESGFSDEVEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVIGG 259

PHA02713

hypothetical protein; Provisional

9-514

4.73e-17

hypothetical protein; Provisional

Pssm-ID: 165086 [Multi-domain] Cd Length: 557 Bit Score: 84.68 E-value: 4.73e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650   9 EKYQHSLNLLNKIKNMKELAEMIDVVLT-AEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQ-REVILYDITAESVSVLL 86
Cdd:PHA02713    4 DDIKHNRRVVSNISNLLDDDILCDVIITiGDGEEIKAHKTILAAGSKYFRTLFTTPMIIRDLvTRVNLQMFDKDAVKNIV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  87 NYMYNAalEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDASNCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEV--- 163
Cdd:PHA02713   84 QYLYNR--HISSMNVIDVLKCADYLLIDDLVTDCESYIKDYTNHDTCIYMYHRLYEMSHIPIVKYIKRMLMSNIPTLitt 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 164 -SLHEEILEIevhQFLTLIKSDDLNISREESILDLVLRWVNHNkelrtvHLVEllkqvrlelvnpsflrqalrrnTMLLC 242
Cdd:PHA02713  162 dAFKKTVFEI---LFDIISTNDNVYLYREGYKVTILLKWLEYN------YITE----------------------EQLLC 210

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 243 DADCVDiIQNAFKAIKTPQQHSLNLRYGMETTSLLLCIGNNSSGI-RSRHRSYGDASFCYDPLSRKTYFISSPKYGEgLG 321
Cdd:PHA02713  211 ILSCID-IQNLDKKSRLLLYSNKTINMYPSCIQFLLDNKQNRNIIpRQLCLVCHDTKYNVCNPCILVYNINTMEYSV-IS 288

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 322 TVCTGVV-----MENNTIIVAGEASASKLSRQKnknveIYRYHDRGNQFWEKLCTAEFRELYALGSIHNDLYVIGGQmki 396
Cdd:PHA02713  289 TIPNHIInyasaIVDNEIIIAGGYNFNNPSLNK-----VYKINIENKIHVELPPMIKNRCRFSLAVIDDTIYAIGGQ--- 360

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 397 kNQYLITNCVDKYSVERDNWKRVSPLPLQLACHAVVTVNNKLYVIGGWTPQMD---------LPDEEPDRLSNKLLQYDP 467
Cdd:PHA02713  361 -NGTNVERTIECYTMGDDKWKMLPDMPIALSSYGMCVLDQYIYIIGGRTEHIDytsvhhmnsIDMEEDTHSSNKVIRYDT 439

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*..
gi 2462587650 468 SQDQWSVRAPMKYSKYRFSTAVVNSEIYVLggigCVGQDKGQVRKCL 514
Cdd:PHA02713  440 VNNIWETLPNFWTGTIRPGVVSHKDDIYVV----CDIKDEKNVKTCI 482

BTB_POZ_KLHL2_Mayven

cd18338

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

22-128

9.59e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349647 [Multi-domain] Cd Length: 121 Bit Score: 76.65 E-value: 9.59e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  22 KNMKELAE---MIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVLLNYMYNAALEINN 98
Cdd:cd18338    10 KVMNELRSqnlLCDVTIVAEDVEIAAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLKMLIDYVYTAEIQVTE 89

                          90       100       110
                  ....*....|....*....|....*....|
gi 2462587650  99 ANVQTVAMAAYFMQMEEVFSVCQKYMMDHM 128
Cdd:cd18338    90 ENVQVLLPAAGLLQLQDVKKTCCEFLESQL 119

BTB2_POZ_KLHL33

cd18263

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

32-134

1.23e-16

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349572 [Multi-domain] Cd Length: 118 Bit Score: 76.39 E-value: 1.23e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  32 DVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVLLNYMYNAALEINNANVQTVAMAAYFM 111
Cdd:cd18263    15 DVQLEADGSIFRVHRVILAAGSDYFRAMFTSGMKESTQSVVQLPTIPAKDLRLLISFAYSGILHLSWENLFEATCTALQL 94

                          90       100
                  ....*....|....*....|...
gi 2462587650 112 QMEEVFSVCQKYMMDHMDASNCL 134
Cdd:cd18263    95 QISGALALCLDFLQREISPARCL 117

BACK_KLHL20

cd18459

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also ...

128-226

1.70e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also termed Kelch-like ECT2-interacting protein (KLEIP), or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis.

Pssm-ID: 350534 [Multi-domain] Cd Length: 100 Bit Score: 75.16 E-value: 1.70e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 128 MDASNCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLNISREESILDLVLRWVNHNKE 207
Cdd:cd18459     2 LDPSNCLGIRAFADTHACRELLRIADKFTQHNFQEVMESEEFMLLPVNQLIDIISSDELNVRSEEQVFNAVMAWVKYNIQ 81

                          90
                  ....*....|....*....
gi 2462587650 208 LRTVHLVELLKQVRLELVN 226
Cdd:cd18459    82 ERRPHLPQVLQHVRLPLLS 100

BACK_KLHL1

cd18509

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a ...

131-230

3.38e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton in brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.

Pssm-ID: 350584 [Multi-domain] Cd Length: 106 Bit Score: 74.67 E-value: 3.38e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 131 SNCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLNISREESILDLVLRWVNHNKELRT 210
Cdd:cd18509     5 SNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQRRC 84

                          90       100
                  ....*....|....*....|
gi 2462587650 211 VHLVELLKQVRLELVNPSFL 230
Cdd:cd18509    85 SDLSMLLAYIRLPLLPPQLL 104

BACK_KLHL7

cd18447

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a ...

127-224

4.64e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a BTB-Kelch protein that constitutes a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 cause autosomal-dominant retinitis pigmentosa.

Pssm-ID: 350522 [Multi-domain] Cd Length: 98 Bit Score: 73.93 E-value: 4.64e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 127 HMDASNCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLNISREESILDLVLRWVNHNK 206
Cdd:cd18447     1 QVDASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDE 80

                          90
                  ....*....|....*...
gi 2462587650 207 ELRTVHLVELLKQVRLEL 224
Cdd:cd18447    81 PNRQPYMVDILAKVRFPL 98

BTB_POZ_KLHL9_13

cd18239

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

12-133

5.30e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349548 [Multi-domain] Cd Length: 128 Bit Score: 74.84 E-value: 5.30e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  12 QHSLNLLNKIKNMKELAEMIDVVLTAE--GEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVLLNYM 89
Cdd:cd18239     5 THSSVVLQGFDQLRGEGLLCDVTLVPGdgDETFPVHRAMMASASDYFKAMFTGGMKEQELMCIKLHGVSKIGLKNIIDFI 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2462587650  90 YNAALEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDASNC 133
Cdd:cd18239    85 YTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVLLISGVTLENC 128

BTB_POZ_ZBTB7

cd18198

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

13-124

5.60e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349507 [Multi-domain] Cd Length: 120 Bit Score: 74.52 E-value: 5.60e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  13 HSLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVLLNYMYNA 92
Cdd:cd18198     8 HSSEILSGLNEQRTQGLLCDVVILVQGREYRTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVSPEALTALLEFAYTA 87

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2462587650  93 ALEINNANVQTVAMAAYFMQMEEVFSVCQKYM 124
Cdd:cd18198    88 TLTVSTANVGDILSAARLLEIPCVSHVCAEIL 119

BACK_KLHL4

cd18510

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares ...

131-230

6.27e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.

Pssm-ID: 350585 [Multi-domain] Cd Length: 106 Bit Score: 73.80 E-value: 6.27e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 131 SNCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLNISREESILDLVLRWVNHNKELRT 210
Cdd:cd18510     5 SNCLGIRSFGDAQGCTELLKVAHSYTMEHFLEVIKNQEFLLLPASEIVKLLASDDINVPDEETIFQALMMWVRHDLQNRQ 84

                          90       100
                  ....*....|....*....|
gi 2462587650 211 VHLVELLKQVRLELVNPSFL 230
Cdd:cd18510    85 KDLGMLLSYIRLPLLPPQLL 104

BACK_KLHL16_gigaxonin

cd18455

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, ...

130-223

1.22e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, also termed Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy.

Pssm-ID: 350530 [Multi-domain] Cd Length: 97 Bit Score: 72.73 E-value: 1.22e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 130 ASNCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLNISREESILDLVLRWVNHNKELR 209
Cdd:cd18455     2 AENCIGIRDFAERFSCPHVHYVATEYLETHFRDVSSTEEFLELSPEKLKELLSRDKLNVGNEEYIFEAVLRWVRHDPEER 81

                          90
                  ....*....|....
gi 2462587650 210 TVHLVELLKQVRLE 223
Cdd:cd18455    82 KVHLKDLMSSCWRS 95

BTB_POZ_ZBTB17_MIZ1

cd18206

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

12-123

1.27e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349515 [Multi-domain] Cd Length: 112 Bit Score: 73.04 E-value: 1.27e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  12 QHSLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTcgllecNQREVILYDIT-AESVSVLLNYMY 90
Cdd:cd18206     4 QHSQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFRMLFV------DQKDVVHLDISnAAGLGQVLEFMY 77

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2462587650  91 NAALEINNANVQTVAMAAYFMQMEEVFSVCQKY 123
Cdd:cd18206    78 TAKLSLSPENVDDVLAVATFLQMQDIVTACHAL 110

BTB_POZ_KLHL15

cd18244

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

1-133

2.34e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349553 [Multi-domain] Cd Length: 137 Bit Score: 73.07 E-value: 2.34e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650   1 MECKIEGKEKYQHSLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAE 80
Cdd:cd18244     1 MAGDVEVYNSSIHDTSVSAGFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTAT 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2462587650  81 SVSVLLNYMYNAALEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDASNC 133
Cdd:cd18244    81 GFSHVLQFMYYGTIELSMLTVHEILQAAMYVQLTEVVKFCCSFLLAKICLDNC 133

BTB_POZ_KLHL32

cd18261

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

13-134

2.62e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349570 [Multi-domain] Cd Length: 133 Bit Score: 73.08 E-value: 2.62e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  13 HSLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVLLNYMYNA 92
Cdd:cd18261    11 HKDAVLAALNQQRNDGILCDITLVAEEQKFHAHKAVLAACSDYFRAMFSLCMVESEADEVNLHGVTSLGLKQALDFAYTG 90

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2462587650  93 ALEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDASNCL 134
Cdd:cd18261    91 QILLEPGVIQDVLAAGSHLQLLELLSLCSHYLIQELNSFNYL 132

BACK_KLHL28_BTBD5

cd18467

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also ...

128-226

3.35e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also termed BTB/POZ domain-containing protein 5 (BTBD5), belongs to the KLHL family. Its function remains unclear.

Pssm-ID: 350542 [Multi-domain] Cd Length: 99 Bit Score: 71.52 E-value: 3.35e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 128 MDASNCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLNISREESILDLVLRWVNHNKE 207
Cdd:cd18467     1 LDPGNCIGISRFAETYGCHDLYLAANKYICQNFEDVCQTEEFFELTHAELDEIVSNDCLNVVTEETVFYALESWIKYDVQ 80

                          90
                  ....*....|....*....
gi 2462587650 208 LRTVHLVELLKQVRLELVN 226
Cdd:cd18467    81 ERQKYLAQLLHCVRLPLLS 99

BTB_POZ_KLHL34

cd18264

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

13-133

3.50e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349573 [Multi-domain] Cd Length: 136 Bit Score: 72.52 E-value: 3.50e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  13 HSLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVLLNYMYNA 92
Cdd:cd18264    11 HGEAVLSQYQSLRAEGFLCDVVLEAEGNEFPAHRSLLACSSDYFRALFKDYTQESKARVIHLPVVSAAGLQRVLDFIYTS 90

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2462587650  93 ALEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDASNC 133
Cdd:cd18264    91 WLSLSLDTLEDTLEAASYLQVTEAIGLCSQYLINNLAPENC 131

BACK_KLHL10

cd18450

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be ...

128-205

4.67e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis.

Pssm-ID: 350525 [Multi-domain] Cd Length: 80 Bit Score: 70.33 E-value: 4.67e-15

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462587650 128 MDASNCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEV-SLHEEILEIEVHQFLTLIKSDDLNISREESILDLVLRWVNHN 205
Cdd:cd18450     1 LTPENCIGIRKFARYYFCPELERKAYRYILRNFEEVaKDSEEFLELSCEELEDIIEDDELNVKEEEVVFEAIVKWIDHD 79

BTB_POZ_ZBTB44

cd18228

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

13-124

1.03e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349537 [Multi-domain] Cd Length: 126 Bit Score: 71.05 E-value: 1.03e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  13 HSLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLEC-------NQREVILYDITAESVSVL 85
Cdd:cd18228     2 HSQELLGKLNSLRNEGHFCDVTIRVQDKIFRAHKVVLAACSDFFRSKLVGQASPRlvlvspaGKCVLDLHHVTVTGFAPL 81

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2462587650  86 LNYMYNAALEINNANVQTVAMAAYFMQMEEVFSVCQKYM 124
Cdd:cd18228    82 LEYAYTSTLSINTENIIDVLAAASYMQMFNVANTCSEFM 120

BTB_POZ_KBTBD4

cd18272

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

32-138

1.18e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349581 [Multi-domain] Cd Length: 140 Bit Score: 71.46 E-value: 1.18e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  32 DVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVLLNYMYNAALEINNANVQTVAMAAYFM 111
Cdd:cd18272    34 DVTISVEGKEFQLHRLVLSAQSCFFRSMFTSNLKEARNRVIELKDVSESVFQLLVDYIYHGTVKLRVEELQETYEVADMY 113

                          90       100
                  ....*....|....*....|....*..
gi 2462587650 112 QMEEVFSVCQKYMMDHMDASNCLGIYY 138
Cdd:cd18272   114 QLTALFEECSRFLARTVQVRNCLQVMW 140

BTB_POZ_ZBTB47_ZNF651

cd18231

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

31-122

1.77e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349540 [Multi-domain] Cd Length: 115 Bit Score: 69.95 E-value: 1.77e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  31 IDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLlECNQREVILYDITAESVSVLLNYMYNAALEINNANVQTVAMAAYF 110
Cdd:cd18231    17 VDIVLVRQRSTFPAHKGVLAAYSQFFHSLFTQNK-QLQRVELSLEALTSQGLQQILNFIYTSKLLVNSCNVQDVLNAAAV 95

                          90
                  ....*....|..
gi 2462587650 111 MQMEEVFSVCQK 122
Cdd:cd18231    96 LQMNDIAASCQE 107

BACK_KLHL23

cd18462

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is ...

128-224

3.62e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is involved in tumorigenesis and resistance to anticancer drug treatment. It also associates with cone-rod dystrophy.

Pssm-ID: 350537 [Multi-domain] Cd Length: 102 Bit Score: 68.61 E-value: 3.62e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 128 MDASNCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLNISREESILDLVLRWVNHNKE 207
Cdd:cd18462     1 LDIDNCLGMHSFAEFHVCPELEKESRRIILSRFEEVWQQEEFLELSKEKLLYILSRENLNVWKEEVLIEAVVKWVAHDVE 80

                          90
                  ....*....|....*..
gi 2462587650 208 LRTVHLVELLKQVRLEL 224
Cdd:cd18462    81 KRIECAYDLLSSIKLDL 97

BTB_POZ_KLHL29_KBTBD9

cd18258

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

17-135

3.88e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349567 [Multi-domain] Cd Length: 125 Bit Score: 69.23 E-value: 3.88e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  17 LLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQR---EVILYDITAESVSVLLNYMYNAA 93
Cdd:cd18258     4 MLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSSRDSGGGeklELTMSNINADVLELLLEFVYTGS 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2462587650  94 LEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDASNCLG 135
Cdd:cd18258    84 LIIDSANAKTLLEAANKFQFHTFCKVCVSFLEKQLTASNCLG 125

BACK_KLHL41_KBTBD10

cd18517

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also ...

131-225

5.14e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also called Kel-like protein 23, or Kelch repeat and BTB domain-containing protein 10, or Kelch-related protein 1 (Krp1), or sarcosine, is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils.

Pssm-ID: 350592 [Multi-domain] Cd Length: 99 Bit Score: 68.26 E-value: 5.14e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 131 SNCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLNISREESILDLVLRWVNHNKELRT 210
Cdd:cd18517     4 GNCLAIFRLGLLLDCPRLAVSARDFVSDRFEQISKEEDFLQLAPHELIAIISSDSLNVEKEELVFEAVMKWVRTDKENRV 83

                          90
                  ....*....|....*
gi 2462587650 211 VHLVELLKQVRLELV 225
Cdd:cd18517    84 KSLGEIFDCIRFRLM 98

BACK_KLHL38

cd18476

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs ...

128-227

8.96e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs to the KLHL family. Its function remains unclear. The klhl38 gene has recently been identified as a possible diapause (a temporary arrest of development during early ontogeny) gene, as it is significantly up-regulated during diapause. It may also be involved in chicken preadipocyte differentiation.

Pssm-ID: 350551 [Multi-domain] Cd Length: 99 Bit Score: 67.46 E-value: 8.96e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 128 MDASNCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLnISREESILDLVLRWVNHNKE 207
Cdd:cd18476     1 LTPSNCLSMIRLSEILNCETLKKKAKDMALQCFPDVAASEDLKELCASELLDYLGDDEL-CGEEEQVFETLMVWIRHDPK 79

                          90       100
                  ....*....|....*....|
gi 2462587650 208 LRTVHLVELLKQVRLELVNP 227
Cdd:cd18476    80 ARKGYIHDLFKKVRLQYVHP 99

BTB2_POZ_BTBD8

cd18286

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

32-108

1.23e-13

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349595 [Multi-domain] Cd Length: 121 Bit Score: 67.67 E-value: 1.23e-13

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462587650  32 DVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVLLNYMYNAALEI-NNANVQTVAMAA 108
Cdd:cd18286    19 DITIKVDGKTFKAHRCILCARSSYFAAMLSGSWAESNSSEITLTGVSHAAVSFVLLFIYGGVLDLpDDVNLGELLSLA 96

BTB_POZ_ZBTB7B_ZBTB15

cd18327

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

12-120

1.38e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349636 [Multi-domain] Cd Length: 127 Bit Score: 67.95 E-value: 1.38e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  12 QHSLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCG------LLECNQREVILYDITA-ESVSV 84
Cdd:cd18327     7 EHSSELLSCLNEQRRAGLLCDLTIKTRGLEYRTHRAVLAACSLYFRKLFTGGgggsgdLGAGGGQDVCELDFVGpEALGA 86

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2462587650  85 LLNYMYNAALEINNANVQTVAMAAYFMQMEEVFSVC 120
Cdd:cd18327    87 LLEFAYTATLTISSSNMREVLRAARLLEIPCVADAC 122

BTB_POZ_trishanku-like

cd18314

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...

32-120

1.47e-13

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349623 [Multi-domain] Cd Length: 96 Bit Score: 66.60 E-value: 1.47e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  32 DVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVLLNYMYNAALEINNANVQTVAMAAYFM 111
Cdd:cd18314     8 DVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMIESNLKEVTLEDVEPEIFETVLKYMYTGQVTLSEENVLDLLMLASKY 87


                  ....*....
gi 2462587650 112 QMEEVFSVC 120
Cdd:cd18314    88 QVPDLEKLC 96

BACK_calicin

cd18503

BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal ...

129-205

2.15e-13

BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa.

Pssm-ID: 350578 [Multi-domain] Cd Length: 78 Bit Score: 65.45 E-value: 2.15e-13

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462587650 129 DASNCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLNISREESILDLVLRWVNHN 205
Cdd:cd18503     2 DRDNCLTALCLATTAGLKDLSDEIYDYIRDNFFDVSGTREFLQCPYDIFSRLLKDENLHVNNEDQVLLALLNWTEHN 78

BTB_POZ_ZBTB8A_BOZF1

cd18329

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

13-124

2.16e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349638 [Multi-domain] Cd Length: 116 Bit Score: 66.77 E-value: 2.16e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  13 HSLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDI-TAESVSVLLNYMYN 91
Cdd:cd18329     4 HQSRLLQQLDEQRKQELFCDCSILVEGQVFKAHRNVLFASSGYFKMLLSQNAKETGQPTVATFDVfSPDTFTIILDFVYS 83

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2462587650  92 AALEINNANVQTVAMAAYFMQMEEVFSVCQKYM 124
Cdd:cd18329    84 GKLSLTSQNVIEVMSAASYLQMTDVISVCKTFI 116

BTB_POZ

cd01165

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

33-110

2.65e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.

Pssm-ID: 349496 [Multi-domain] Cd Length: 79 Bit Score: 65.38 E-value: 2.65e-13

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462587650  33 VVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVLLNYMYNAALEINNANVQTVAMAAYF 110
Cdd:cd01165     1 VVLVVEGEKFHVNKELLAQSSEYFRALFRGGFRESGQAEINLRDISPEDFRALLEFLYGGKRDLDASNLLELLEAANF 78

BTB_POZ_ZBTB46

cd18230

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

13-131

2.83e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349539 [Multi-domain] Cd Length: 125 Bit Score: 67.01 E-value: 2.83e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  13 HSLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFtCGLLECNQREVILY-DI-TAESVSVLLNYMY 90
Cdd:cd18230     4 HYRHLLRELNEQRQHGILCDVCIIVEGKIFKAHKNVLLGSSRYFKTLY-CQVQKTSDQATVTHlDIvTAQGFKAIIDFMY 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2462587650  91 NAALEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDAS 131
Cdd:cd18230    83 SAHLALTSKNVIEVMSAASYLQMTDIVQACHNFIKAALDIS 123

BTB_POZ_BAB-like

cd18315

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...

32-90

3.25e-13

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349624 [Multi-domain] Cd Length: 85 Bit Score: 65.26 E-value: 3.25e-13

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462587650  32 DVVLTAEGEKFPCHRLVLAAFSPYFKAMFtCGLLECNQREVILYDITAESVSVLLNYMY 90
Cdd:cd18315     3 DVTLACEGGSLKAHKLVLAAASPYFAALL-KETPPDEHPVIILPDVPYSELKALLDFIY 60

BTB_POZ_ZBTB7C_ZBTB36

cd18328

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

13-124

3.42e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349637 [Multi-domain] Cd Length: 120 Bit Score: 66.44 E-value: 3.42e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  13 HSLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLeCNQREVILYD-ITAESVSVLLNYMYN 91
Cdd:cd18328     8 HSSEVLCSLNEQRHDGLLCDVVLIVQDQEYRTHRSVLAACSKYFKKLFTAGTL-ADQPYVYEIDfVTPEALSAILEFAYT 86

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2462587650  92 AALEINNANVQTVAMAAYFMQMEEVFSVCQKYM 124
Cdd:cd18328    87 STLTITTSNVKHILNAAQMLEIQCIINVCLEIM 119

BTB_POZ_BPM_plant

cd18280

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

32-94

4.72e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349589 [Multi-domain] Cd Length: 121 Bit Score: 66.20 E-value: 4.72e-13

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462587650  32 DVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVLLNYMYNAAL 94
Cdd:cd18280    16 DVTFNVDGEKFRAHKLVLAARSPVFRSMLFGPMREENEGEIVIEDVEPPVFKALLHFIYKDEL 78

BTB_POZ_ZBTB8

cd18199

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

13-124

1.26e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349508 [Multi-domain] Cd Length: 113 Bit Score: 64.75 E-value: 1.26e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  13 HSLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDI-TAESVSVLLNYMYN 91
Cdd:cd18199     1 HQSRLLGQLNEQRKQDFFCDCSIIVEGRIFKAHRNVLFASSGYFRMLLSHYIQDTGRPSTASFDVfSSDAFSIILDFVYS 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2462587650  92 AALEINNANVQTVAMAAYFMQMEEVFSVCQKYM 124
Cdd:cd18199    81 GKLSLTSQNVIEVMSAASYLQMTDVINVCKTFI 113

BTB_POZ_BTBD18

cd18293

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

32-120

1.27e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349602 [Multi-domain] Cd Length: 120 Bit Score: 64.81 E-value: 1.27e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  32 DVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLL-ECNQREVILYDITAESVSVLLNYMYNAALEINNANVQTVAMAAYF 110
Cdd:cd18293    17 DVLLQAEGESVPAHCCVLSACSPYLTERLSSEPPpAGQKVVLELQGLKAHTLLKLVDFLYTSELEVSSEEAQDVLAAARR 96

                          90
                  ....*....|
gi 2462587650 111 MQMEEVFSVC 120
Cdd:cd18293    97 LQISELESLC 106

BTB_POZ_ZBTB3

cd18323

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

13-122

1.35e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349632 [Multi-domain] Cd Length: 128 Bit Score: 64.85 E-value: 1.35e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  13 HSLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKaMFTCGLLEcnQREVILYD---ITAESVSVLLNYM 89
Cdd:cd18323     6 HSRHLLQSLREQRHQGFLCDCTVLVGSTQFLAHRAVLASCSPFFH-MFYKEQLD--KRDLVCINneiVTAPAFSLLLEFM 82

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2462587650  90 YNAALEINNANVQTVAMAAYFMQMEEVFSVCQK 122
Cdd:cd18323    83 YEGRLSFNDTPVEDVLAAASYLHMNDIVKVCKK 115

BTB_POZ_KLHL16_gigaxonin

cd18245

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

30-124

1.52e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349554 [Multi-domain] Cd Length: 111 Bit Score: 64.28 E-value: 1.52e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  30 MIDVVLTAEGEKFPCHRLVLAAFSPYFKAMF--TCGLLECNQREVILYDITAESVSVLLNYMYNAALEINNANVQTVAMA 107
Cdd:cd18245    14 LCDATLVVGGEEIPVQKNVLAAASPYFRAKLnyNPPKDDGSTYKIELEGISVEVMEEILDYIYTGQIKLSEDNIQDIVQA 93

                          90
                  ....*....|....*..
gi 2462587650 108 AYFMQMEEVFSVCQKYM 124
Cdd:cd18245    94 ADLLLMTDLKDLCCEFL 110

BACK_KLHL40_like

cd18477

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The ...

131-225

1.71e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells.

Pssm-ID: 350552 [Multi-domain] Cd Length: 99 Bit Score: 63.71 E-value: 1.71e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 131 SNCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLNISREESILDLVLRWVNHNKELRT 210
Cdd:cd18477     4 GNCLAIFRLGLLLDCPRLAVSARDFICAHFTLVAKDEDFLGLSADELIAIISSDGLNVEKEEAVFEAVMKWVREAKENRQ 83

                          90
                  ....*....|....*
gi 2462587650 211 VHLVELLKQVRLELV 225
Cdd:cd18477    84 KALPTVFESIRFRLL 98

BACK_KLHL35

cd18474

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs ...

129-204

2.14e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs to the KLHL family. Its function remains unclear. Hypermethylation of KLHL35 is associated with hepatocellular carcinoma and abdominal aortic aneurysm.

Pssm-ID: 350549 [Multi-domain] Cd Length: 79 Bit Score: 62.91 E-value: 2.14e-12

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462587650 129 DASNCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLNISREESILDLVLRWVNH 204
Cdd:cd18474     2 GANNCLALLAAADALHCAPLQEHCIRVLLRDFAQAARHPSFLKLELQLVLELLADDSLAVRSEEVVLEAALRWVDA 77

BTB_POZ_ZBTB27_BCL6

cd18331

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

12-124

2.30e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349640 [Multi-domain] Cd Length: 118 Bit Score: 64.11 E-value: 2.30e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  12 QHSLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTcGLLECNQREVILY-DITAESVSVLLNYMY 90
Cdd:cd18331     6 RHASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIFT-DQLKCNLSVINLDpEINPEGFNILLDFMY 84

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2462587650  91 NAALEINNANVQTVAMAAYFMQMEEVFSVCQKYM 124
Cdd:cd18331    85 TSRLNLREGNIMAVMATAMYLQMEHVVDTCRKFI 118

BACK_KLHL40_KBTBD5

cd18516

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also ...

131-225

8.70e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5, or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy.

Pssm-ID: 350591 [Multi-domain] Cd Length: 99 Bit Score: 61.70 E-value: 8.70e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 131 SNCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLNISREESILDLVLRWVNHNKELRT 210
Cdd:cd18516     4 SNCLAIFRLGLLLDCPRLAVAARDFICDRFQLIARDEDFLQLSPDELIAIISSDSLNVEKEEDVFEAVMKWVGKDQEERT 83

                          90
                  ....*....|....*
gi 2462587650 211 VHLVELLKQVRLELV 225
Cdd:cd18516    84 KALPVLLESIRFRLM 98

BACK_KLHL21

cd18460

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a ...

128-225

1.14e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively.

Pssm-ID: 350535 [Multi-domain] Cd Length: 101 Bit Score: 61.35 E-value: 1.14e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 128 MDASNCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLNISREESILDLVLRWVNHNKE 207
Cdd:cd18460     1 LDVSNCLEMQDFAEAFACRGLAEAAKRFILRHIVELAKGEQFERLPLKRLLEYLSDDGLCVDKEETAYQIALRWVKADPK 80

                          90
                  ....*....|....*...
gi 2462587650 208 LRTVHLVELLKQVRLELV 225
Cdd:cd18460    81 HRQHFWPELLQHVRLPFV 98

BTB_POZ_ZBTB19_PATZ1

cd18207

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

12-122

1.24e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349516 [Multi-domain] Cd Length: 128 Bit Score: 62.29 E-value: 1.24e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  12 QHSLNLLNKIKNM-KELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQ-REVILYDITAESVSVLLNYM 89
Cdd:cd18207     8 QHSADMLHNLNQQrKSGGRFCDVLLRVGEESFPAHRAVLAACSEYFESVFSAQEGDGGTpRELEMHTISSKVFGDILDFA 87

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2462587650  90 YNAALEINNANVQTVAMAAYFMQMEEVFSVCQK 122
Cdd:cd18207    88 YTSRIVVRLESFPELMTAAKFLLMRSVIDICQE 120

BTB_POZ_ZBTB10

cd18201

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

17-129

1.86e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349510 [Multi-domain] Cd Length: 122 Bit Score: 61.51 E-value: 1.86e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  17 LLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLE-CNQREVILYDITA-ESVSVLLNYMYNAAL 94
Cdd:cd18201     8 LLQELNEQRKKGILCDVNIVVSGKVFRAHKNILVAGSRFFKTLYCFTNKEsCDQTTVTHLDVVAvQGFSVILDFMYSGNL 87

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2462587650  95 EINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMD 129
Cdd:cd18201    88 VLTSQNAIEVMSVASYLQMTEVVQSCRNFIKDALN 122

BACK_KBTBD2

cd18479

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...

128-223

2.34e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulating the insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation.

Pssm-ID: 350554 [Multi-domain] Cd Length: 96 Bit Score: 60.46 E-value: 2.34e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 128 MDASNCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLNISREESILDLVLRWVNHNKE 207
Cdd:cd18479     1 INAENCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQEAFMQLSHDLLIDILSSDNLNVEKEETVREAAMLWLEYNTE 80

                          90
                  ....*....|....*.
gi 2462587650 208 LRTVHLVELLKQVRLE 223
Cdd:cd18479    81 SRSQYLSSVLSQIRID 96

BTB_POZ_ZBTB31_myoneurin

cd18217

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

13-121

2.51e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349526 [Multi-domain] Cd Length: 111 Bit Score: 60.92 E-value: 2.51e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  13 HSLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFtcgllECNQREVILYD---ITAESVSVLLNYM 89
Cdd:cd18217     1 HCEQLLERLNKQREAGFLCDCTIVIGQFQFKAHRNVLAAFSEYFGAQY-----KDTEDNIVFLDqsqVSADGFQKLLEFI 75

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2462587650  90 YNAALEINNANVQTVAMAAYFMQMEEVFSVCQ 121
Cdd:cd18217    76 YTGNLNLDSWNVAEIHQAASYLGMEEVVAKCK 107

BACK

cd14733

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...

129-183

3.02e-11

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.

Pssm-ID: 350515 [Multi-domain] Cd Length: 55 Bit Score: 58.83 E-value: 3.02e-11

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2462587650 129 DASNCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKS 183
Cdd:cd14733     1 DPENCLGILELADLYNLEELKEKALKFILENFEEVSKSEEFLELSVELLLELLSS 55

BTB_POZ_ZBTB8B

cd18330

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

17-124

3.92e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349639 [Multi-domain] Cd Length: 113 Bit Score: 60.33 E-value: 3.92e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  17 LLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDI-TAESVSVLLNYMYNAALE 95
Cdd:cd18330     5 LLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLIHYIQDSGRHSTASLDIvTSEAFSIILDFLYSGKLD 84

                          90       100
                  ....*....|....*....|....*....
gi 2462587650  96 INNANVQTVAMAAYFMQMEEVFSVCQKYM 124
Cdd:cd18330    85 LCSENVIEVMSAASYLQMTDVVNFCKGYI 113

BTB_POZ_ZBTB49

cd18233

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

13-124

4.32e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349542 [Multi-domain] Cd Length: 112 Bit Score: 60.29 E-value: 4.32e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  13 HSLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGllECNQREVILYDITAES-VSVLLNYMYN 91
Cdd:cd18233     1 HSCHLLQQLHEQRIQGLLCDCMLVVKGVCFKAHKNVLAAFSQYFRSLFQNS--SSQKNDVFHLDIKNVGgIGQILDFMYT 78

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2462587650  92 AALEINNANVQTVAMAAYFMQMEEVFSVCQKYM 124
Cdd:cd18233    79 SHLDLNQDNVQVMLDIAQCLQVQNVLNMCYTFL 111

BTB_POZ_KLHL31_KBTBD1

cd18260

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

13-134

5.63e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349569 [Multi-domain] Cd Length: 120 Bit Score: 60.21 E-value: 5.63e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  13 HSLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTcglLECNQREVILYDITAESVSVLLNYMYNA 92
Cdd:cd18260     1 YGANLLEGLNRMRQERFLCDLTIATKTKSFDVHKVVMASCSEYFRNILK---KDPSLQRVELNDISPLGLATVITYAYTG 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2462587650  93 ALEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDASNCL 134
Cdd:cd18260    78 KLTLSLYTIGSTISAASYLQIHALVKMCCDFLMQEMNVENCM 119

BACK_KLHL25_ENC2

cd18514

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also ...

131-225

9.15e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1).

Pssm-ID: 350589 [Multi-domain] Cd Length: 99 Bit Score: 58.70 E-value: 9.15e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 131 SNCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLNISREESILDLVLRWVNHNKELRT 210
Cdd:cd18514     4 SNCLGMMLLSDAHQCRRLYELSWRMCLVHFETVRESEDFYSLSKDKLLDLISSDELEIEDEQVVFNAVLQWVKYDLEKRK 83

                          90
                  ....*....|....*
gi 2462587650 211 VHLVELLKQVRLELV 225
Cdd:cd18514    84 DYLPELLRNVRLALL 98

BTB_POZ_ZBTB11

cd18202

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

12-121

1.09e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349511 [Multi-domain] Cd Length: 118 Bit Score: 59.09 E-value: 1.09e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  12 QHSLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFT-CGLLECNQREVILYDITAESVSVLLNYMY 90
Cdd:cd18202     1 KHGQTVLDQLNQQRLNNQFCDVTLLIEGEEYKAHKSVLAANSEYFRELFIeKGAVSSHEAVVDLSGFCKSSFLPLLEFAY 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2462587650  91 NAALEINNANVQTVAMAAYFMQMEEVFSVCQ 121
Cdd:cd18202    81 TSELTFDFCSMAEVAMLARHLFMNEVLEICE 111

BTB_POZ_ZBTB3-like

cd18194

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

12-122

1.33e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349503 [Multi-domain] Cd Length: 128 Bit Score: 59.45 E-value: 1.33e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  12 QHSLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLlecNQREVILYD---ITAESVSVLLNY 88
Cdd:cd18194     5 EHSRQLLQCLREQRSQGFLCDCTVLVGSAQFPAHRAVLASCSMYFHLFYRDRL---DKRDLVRLNsdiVTAPAFGLLLDF 81

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2462587650  89 MYNAALEINNANVQTVAMAAYFMQMEEVFSVCQK 122
Cdd:cd18194    82 MYEGRLALRDLPVEDVLAAASYLHMYDIVKVCKG 115

BTB2_POZ_ABTB1_BPOZ1

cd18296

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

32-129

2.91e-10

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349605 [Multi-domain] Cd Length: 121 Bit Score: 58.08 E-value: 2.91e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  32 DVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLEC--NQRE---VILYDITAESVSVLLNYMYNAALEINNANVQTVAM 106
Cdd:cd18296    19 DVCFQVEGHRFPCHKAFFCGRSDYFKALLRDHFAESeeNNGSipvVTLHDVSPEVFAIVLYYIYTDDTDLPPENAYDVLY 98

                          90       100
                  ....*....|....*....|...
gi 2462587650 107 AAYFMQMEEVFSVCQKYMMDHMD 129
Cdd:cd18296    99 VADMYLLPGLKRLCGTVLAQSLD 121

PHA02790

Kelch-like protein; Provisional

27-498

3.96e-10

Kelch-like protein; Provisional

Pssm-ID: 165153 [Multi-domain] Cd Length: 480 Bit Score: 62.37 E-value: 3.96e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  27 LAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLEcNQREV--ILYDITAESVSVLLNYMYNAALEINNANVQTV 104
Cdd:PHA02790   18 MTKKFKTIIEAIGGNIIVNSTILKKLSPYFRTHLRQKYTK-NKDPVtrVCLDLDIHSLTSIVIYSYTGKVYIDSHNVVNL 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 105 AMAAYFMQMEEVFSVCQKYMMDHMDASNCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEvsLHEEILEIEVHQFLTLI-KS 183
Cdd:PHA02790   97 LRASILTSVEFIIYTCINFILRDFRKEYCVECYMMGIEYGLSNLLCHTKDFIAKHFLE--LEDDIIDNFDYLSMKLIlES 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 184 DDLNISREESILDLVLRWvnhnkelrtvhlvellkqvrlelvnpsFLRQALRRNTMLLcdadcvdIIQNAFKAIKTPQQH 263
Cdd:PHA02790  175 DELNVPDEDYVVDFVIKW---------------------------YMKRRNRLGNLLL-------LIKNVIRSNYLSPRG 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 264 SLNLRYGMETTSLLLCignnssgirsrhrsygdasfcyDPLSRKTY---FISSPKYGEGLGTV---CTGVVMENNTIIVA 337
Cdd:PHA02790  221 INNVKWILDCTKIFHC----------------------DKQPRKSYkypFIEYPMNMDQIIDIfhmCTSTHVGEVVYLIG 278

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 338 GEAsasklsrqknkNVEIYRYHDRGN---QFWEKLCTAEFRELYALG-SIHNDLYVIGGqmkIKNqyliTNCVDKYSVER 413
Cdd:PHA02790  279 GWM-----------NNEIHNNAIAVNyisNNWIPIPPMNSPRLYASGvPANNKLYVVGG---LPN----PTSVERWFHGD 340

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 414 DNWKRVSPLpLQLACH-AVVTVNNKLYVIGGWTpqmdlpdeEPDRLSNKLLqydPSQDQWSVRAPMKYSKYRFSTAVVNS 492
Cdd:PHA02790  341 AAWVNMPSL-LKPRCNpAVASINNVIYVIGGHS--------ETDTTTEYLL---PNHDQWQFGPSTYYPHYKSCALVFGR 408


                  ....*.
gi 2462587650 493 EIYVLG 498
Cdd:PHA02790  409 RLFLVG 414

BTB_POZ_ZBTB18_2-like

cd18325

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

13-126

6.92e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349634 [Multi-domain] Cd Length: 128 Bit Score: 57.35 E-value: 6.92e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  13 HSLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLlecNQREVILYD---ITAESVSVLLNYM 89
Cdd:cd18325     6 HSRQLLQCLSQQRHQGFLCDCTVLVGEAQFRAHRAVLASCSMYFHLFYRDQL---DKRDIVHLNsdiVTAPAFSLLLEFM 82

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2462587650  90 YNAALEINNANVQTVAMAAYFMQMEEVFSVCQKYMMD 126
Cdd:cd18325    83 YEGKLEFSSLPVEDVLAAASYLHMYDIVKVCKGKLKD 119

BTB_POZ_BTBD19

cd18294

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

21-124

7.00e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349603 [Multi-domain] Cd Length: 111 Bit Score: 56.87 E-value: 7.00e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  21 IKNMKELA---EMIDV--VLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECN-QREVILYDITAESVSVLLNYMYNAAL 94
Cdd:cd18294     2 AADMKSLInnpEFSDVkfLVGPERQEIFAHKCILAARCEVFRAMFLTGPQKEStQSPLVLSDIEPEVFRAVLEFIYTNCV 81

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2462587650  95 EINNANV-QTVAMAAYFmQMEEVFSVCQKYM 124
Cdd:cd18294    82 TLSNHTViEVLAAAVEY-GLDELRKLCERFI 111

BTB_POZ_ZBTB27-like

cd18215

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

12-123

9.03e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349524 [Multi-domain] Cd Length: 113 Bit Score: 56.42 E-value: 9.03e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  12 QHSLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLecNQREVILYD--ITAESVSVLLNYM 89
Cdd:cd18215     1 RHASDVLLNLNRLRSRDILTDVVLVVGREQFRAHKTVLMACSGLFYSIFTDQLK--NNVSVINLDpeIEPEGFRILLDFM 78

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2462587650  90 YNAALEINNANVQTVAMAAYFMQMEEVFSVCQKY 123
Cdd:cd18215    79 YTSRLNLREGNIMAVMATAMYLQMEHVVDTCRKF 112

BTB_POZ_KLHL14_printor

cd18243

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

13-132

9.37e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349552 [Multi-domain] Cd Length: 130 Bit Score: 56.97 E-value: 9.37e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  13 HSLNLLNKiknmKELaeMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGllecnqrEVILYDITAESVSVLLNYMYNA 92
Cdd:cd18243    21 HGLNLLWR----KQL--FCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSIN-------NLVLQGCSSIGLRLVLEYLYTA 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2462587650  93 ALEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDASN 132
Cdd:cd18243    88 NVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQN 127

BTB_POZ_ZBTB42

cd18956

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

12-121

1.08e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 42 (ZBTB42); ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. It is enriched in skeletal muscles, especially at the neuromuscular junction. A ZBTB42 mutation has been identified to define a novel lethal congenital contracture syndrome (LCCS6), a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). ZBTB42 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349737 [Multi-domain] Cd Length: 129 Bit Score: 56.74 E-value: 1.08e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  12 QHSLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGllECNQREVILYD---ITAESVSVLLNY 88
Cdd:cd18956     5 EHGGRLLGRLRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVYFHLFYRDR--PAGGRDTVRLNgdiVTAPAFGRLLDF 82

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2462587650  89 MYNAALEINNANVQTVAMAAYFMQMEEVFSVCQ 121
Cdd:cd18956    83 MYEGRLDLRSLPVEDVLAAASYLHMYDIVKVCK 115

BTB_POZ_GCL

cd18305

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

32-127

1.29e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349614 [Multi-domain] Cd Length: 115 Bit Score: 56.13 E-value: 1.29e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  32 DVVLTAEGEKFPCHRLVLAAfSPYFKAMFTCGLLECNQREV---ILYD-ITAESVSVLLNYMYNAALEINNANVQTVAMA 107
Cdd:cd18305    17 DITICALGREWKLHKIYLCQ-SGYFASMFSGSWKESKETVInleIPDDnITVEALNVVFGSLYRDEIEIKPSRVVSILAA 95

                          90       100
                  ....*....|....*....|
gi 2462587650 108 AYFMQMEEVFSVCQKYMMDH 127
Cdd:cd18305    96 ATLLQLDGLIQQCSEVMKET 115

BTB_POZ_BACH1

cd18277

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

9-124

2.22e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349586 [Multi-domain] Cd Length: 120 Bit Score: 55.46 E-value: 2.22e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650   9 EKYQHSLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTcGLLECNQREVILYDITAESVSVLLNY 88
Cdd:cd18277     6 ESSVHSTNVLLSLNDQRKKDVLCDVTILVEGQRFRAHRSVLAACSSYFHSRIV-GQADAELNITLPEEVTVKGFEPLIQF 84

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2462587650  89 MYNAALEINNANVQTVAMAAYFMQMEEVFSVCQKYM 124
Cdd:cd18277    85 AYTAKLILSKDNVDEVCKCVEFLSVHNIEESCFQFL 120

BACK_KLHL33

cd18472

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs ...

128-202

2.61e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs to the KLHL family. Its function remains unclear. KLHL33 SNPs may be associated with prostate cancer risk.

Pssm-ID: 350547 [Multi-domain] Cd Length: 75 Bit Score: 53.93 E-value: 2.61e-09

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462587650 128 MDASNCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLNISREESILDLVLRWV 202
Cdd:cd18472     1 LSPANCLELWAFADAATLPRLAAAARAFALKHFAEVAASAAFLSLPLARLLELLRSDELEVAEEEAVFEAAVRWL 75

BTB_POZ_ZBTB28_BCL6B

cd18332

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

12-124

2.92e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349641 [Multi-domain] Cd Length: 114 Bit Score: 54.86 E-value: 2.92e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  12 QHSLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVLLNYMYN 91
Cdd:cd18332     1 RHSSDVLLNLNELRKRDILTDVTLLVGGTPLRAHKAVLIACSGFFYSIFSGRVGEGVSVLTLPSGLEARGFQLLLDFMYT 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2462587650  92 AALEINNANVQTVAMAAYFMQMEEVFSVCQKYM 124
Cdd:cd18332    81 SRLPLTPRTVPAVLAAATYLQMEHVVETCRRFI 113

BTB_POZ_ZBTB48_TZAP_KR3

cd18232

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

13-123

5.07e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349541 [Multi-domain] Cd Length: 108 Bit Score: 53.99 E-value: 5.07e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  13 HSLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGllecNQREVILYDITAESVSVLLNYMYNA 92
Cdd:cd18232     1 HSVKVLQALNKQREEGQYCDATLDVGGRVFKAHWSVLACCSHFFQSLYGDG----TSGSVVLPESFAEVFGLLLDFFYTG 76

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2462587650  93 ALEINNANVQTVAMAAYFMQMEEVFSVCQKY 123
Cdd:cd18232    77 ELALTRENRDRVLLAAKELRVPEAVELCQRF 107

BTB_POZ_BACH2

cd18278

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

9-124

5.16e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349587 [Multi-domain] Cd Length: 124 Bit Score: 54.57 E-value: 5.16e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650   9 EKYQHSLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTcGLLECNQREVILYDITAESVSVLLNY 88
Cdd:cd18278    10 ESTVHCTNILLCLNDQRKQDILCDVTLIVEGKEFRAHRAVLAACSEYFLQALV-GQTENDLVVSLPEEVTARGFGPLLQF 88

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2462587650  89 MYNAALEINNANVQTVAMAAYFMQMEEVFSVCQKYM 124
Cdd:cd18278    89 AYTAKLLLSRENIQEVIRCAEFLRMHNLEDSCFRFL 124

BTB_POZ_ABTB2-like

cd18297

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-132

5.59e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349606 [Multi-domain] Cd Length: 117 Bit Score: 54.20 E-value: 5.59e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  29 EMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVLLNYMYNAALEINNANvQTVAM-- 106
Cdd:cd18297    11 EMSDVTFLVEGRPFYAHKIVLVTASDRFKSMLSSGSTEAQTPVIEIPDIRYDIFQLMMQYLYTGGVESLDVA-QDDALel 89

                          90       100
                  ....*....|....*....|....*...
gi 2462587650 107 --AAYFMQMEEVFSVCQKYMMDHMDASN 132
Cdd:cd18297    90 lrAASFFQLDGLKRHCEILLSQQIDLDN 117

Kelch

Kelch domain;

437-491

6.77e-09

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 51.79 E-value: 6.77e-09

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2462587650  437 KLYVIGGWTPQMDLpdeepdrlsNKLLQYDPSQDQWSVRAPMKYSKYRFSTAVVN 491
Cdd:smart00612   1 KIYVVGGFDGGQRL---------KSVEVYDPETNKWTPLPSMPTPRSGHGVAVIN 46

BTB_POZ_ZBTB37

cd18222

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

14-124

1.19e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349531 [Multi-domain] Cd Length: 123 Bit Score: 53.51 E-value: 1.19e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  14 SLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESvsvLLNYMYNAA 93
Cdd:cd18222     9 SNSVLSHLNQLRMQGRLCDIVVNVQGQSFRAHKVVLAASSPYFRDHMSLNEMSTVSISVIKNPTVFEQ---LLSFCYTGR 85

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2462587650  94 LEINNANVQTVAMAAYFMQMEEVFSVCQKYM 124
Cdd:cd18222    86 ICLQLADIISYLTAASFLQMQHIIDKCTQIL 116

BTB_POZ_ZBTB18_RP58

cd18324

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

12-122

1.40e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349633 [Multi-domain] Cd Length: 147 Bit Score: 53.89 E-value: 1.40e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  12 QHSLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLlecNQREVILYD---ITAESVSVLLNY 88
Cdd:cd18324     5 DHSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFHLFYKDQL---DKRDIVHLNsdiVTAPAFALLLEF 81

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2462587650  89 MYNAALEINNANVQTVAMAAYFMQMEEVFSVCQK 122
Cdd:cd18324    82 MYEGKLQFKDLPIEDVLAAASYLHMYDIVKVCKK 115

BTB_POZ_calicin

cd18307

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

32-123

1.81e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349616 [Multi-domain] Cd Length: 97 Bit Score: 52.11 E-value: 1.81e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  32 DVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDI---TAESVSVLLNYMYNAALEINNANVQTVAMAA 108
Cdd:cd18307     3 DVVISVDNHSFAAHRNVLAAVSPFVKSLISSNDMKATDELSITIDCdylSPETVEQLLDYFYTGKIVISEKNVEDLLKGA 82

                          90
                  ....*....|....*
gi 2462587650 109 YFMQMEEVFSVCQKY 123
Cdd:cd18307    83 KYFNIPRLKDHCVDF 97

BTB_POZ_ZBTB43

cd18227

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

14-120

2.24e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349536 [Multi-domain] Cd Length: 121 Bit Score: 52.63 E-value: 2.24e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  14 SLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFkamftCG-LLECNQREVILYDITAESV--SVLLNyMY 90
Cdd:cd18227     9 SSTILQKLNQQRQQGQLCDISVVVQGHLFRAHKAVLAASSPYF-----CDqVLLKNSRRIVLPDVMNPRVfeNILLS-CY 82

                          90       100       110
                  ....*....|....*....|....*....|
gi 2462587650  91 NAALEINNANVQTVAMAAYFMQMEEVFSVC 120
Cdd:cd18227    83 TGRLVLPAPEIVSYLTAASFLQMWHVVDKC 112

BTB_POZ_ZBTB5

cd18196

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-124

2.47e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5); ZBTB5 is a POZ domain Kruppel-like zinc finger (POK) family transcription repressor of cell cycle arrest gene p21 and a potential proto-oncogene stimulating cell proliferation. ZBTB5 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349505 [Multi-domain] Cd Length: 126 Bit Score: 52.74 E-value: 2.47e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  28 AEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYD--ITAESVSVLLNYMYNAALEINNANVQTVA 105
Cdd:cd18196    19 GQLCDCVIVVGNRHFKAHRSVLAACSTHFRALFTVAEGDQTMNMIQLDSevVTAEAFAALIDMMYTSTLMLGESNVMDVL 98

                          90
                  ....*....|....*....
gi 2462587650 106 MAAYFMQMEEVFSVCQKYM 124
Cdd:cd18196    99 LAASHLHLNSVVKACKHYL 117

BTB_POZ_BTBD17

cd18292

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

14-124

3.20e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349601 [Multi-domain] Cd Length: 114 Bit Score: 51.90 E-value: 3.20e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  14 SLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFT-CGLLECNQREVILYDiTAESVSV---LLNYM 89
Cdd:cd18292     1 SREFLQDIAQLYNNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSnDWWSESKQSEIELVE-DPECAAVfekFLRYL 79

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2462587650  90 YNAALEINNANVQTVAMAAYFMQMEEVFSVCQKYM 124
Cdd:cd18292    80 YTGQISVNLETALPLLMLADKYNVTDLKQLCVDFM 114

BTB1_POZ_RhoBTB

cd18299

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

32-120

3.27e-08

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349608 [Multi-domain] Cd Length: 103 Bit Score: 51.83 E-value: 3.27e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  32 DVVLTA-EGEKFPCHRLVLAAFSPYFKAMFtcglleCNQREVIL-YDITAESVSVLLNYMYNAALEINNANVQTVAMAAY 109
Cdd:cd18299    14 DVVFILqGGVRIFAHRIVLAAASSVFADLF------LMMTVVTLdSDITPEAFRRVLEFLYTGVLDENEDDLKELKDAAE 87

                          90
                  ....*....|.
gi 2462587650 110 FMQMEEVFSVC 120
Cdd:cd18299    88 LLELFDLVMMC 98

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

427-479

3.40e-08

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 49.92 E-value: 3.40e-08

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2462587650 427 ACHAVVTVNNKLYVIGGWTPQmdlpdeepdRLSNKLLQYDPSQDQWSVRAPMK 479
Cdd:pfam01344   3 SGAGVVVVGGKIYVIGGFDGN---------QSLNSVEVYDPETNTWSKLPSMP 46

BACK_KLHL25_like

cd18464

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The ...

131-225

5.11e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The family includes KLHL25 and KLHL37. KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.

Pssm-ID: 350539 [Multi-domain] Cd Length: 98 Bit Score: 50.96 E-value: 5.11e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 131 SNCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLNISREESILDLVLRWVNHNKELRT 210
Cdd:cd18464     3 SNCLGMLLLSDAHQCQRLYELSWRMCLANFTTLRKTEDFLSLPKDKLLELVSSEELEVEDERLVYEAVIGWIRYDLPRRH 82

                          90
                  ....*....|....*
gi 2462587650 211 VHLVELLKQVRLELV 225
Cdd:cd18464    83 EVLPELLRSVRLALL 97

BTB_POZ_ZBTB23_GZF1

cd18211

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

16-120

1.16e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349520 [Multi-domain] Cd Length: 128 Bit Score: 51.01 E-value: 1.16e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  16 NLLNKIKNMKELAEMIDVVLTAE----GEKFPCHRLVLAAFSPYFKAMF-TCGLLECNQREVILYDITAESVSVLLNYMY 90
Cdd:cd18211    11 NLLNEMHKLRLLGHLCDVTVQVEhqgsKEEFSAHKAVLAASSKYFKEVFlNEKISDGKNTNVMLNEIYTADFASFLEFVY 90

                          90       100       110
                  ....*....|....*....|....*....|
gi 2462587650  91 NAALEINNANVQTVAMAAYFMQMEEVFSVC 120
Cdd:cd18211    91 TAKVEVEEDRVQRMLEIAEKLKCLDLSETC 120

BACK_KLHL34

cd18473

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 34 (KLHL34); KLHL34 belongs ...

132-230

1.45e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 34 (KLHL34); KLHL34 belongs to the KLHL family. Its function remains unclear. The methylation status of KLHL34 cg14232291 may be a predictive candidate of sensitivity to preoperative chemoradiation therapy.

Pssm-ID: 350548 Cd Length: 106 Bit Score: 50.12 E-value: 1.45e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 132 NCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHE----EILEIEVHQFLTLIKSDDLNISREESILDLVLRWVNHNKE 207
Cdd:cd18473     5 NCCFSANIAARFGLPDALKAAEKYIISNLWRLLASDaddaGLLELNLESLQAVLEADDIPRVKESRLLTLVLEWLNQDES 84

                          90       100
                  ....*....|....*....|...
gi 2462587650 208 lRTVHLVELLKQVRLELVNPSFL 230
Cdd:cd18473    85 -RLAYANALLSRIRYGLVPVEEL 106

BACK_KBTBD6_7

cd18482

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing ...

128-221

1.54e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing proteins, KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling.

Pssm-ID: 350557 [Multi-domain] Cd Length: 99 Bit Score: 49.81 E-value: 1.54e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 128 MDASNCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEIL-EIEVHQFLTLIKSDDLNISREESILDLVLRWVNHNK 206
Cdd:cd18482     1 LDLSNCAGILKFADAFDNRELKSKALAFIARNFQQLLAKEEELcELSLAQLKEVLMLDSLDVDSERKVCSVAVQWIEANL 80

                          90
                  ....*....|....*
gi 2462587650 207 ELRTVHLVELLKQVR 221
Cdd:cd18482    81 KERAASAAEVLKCVR 95

BTB_POZ_ZBTB4

cd18195

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

13-96

3.13e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349504 [Multi-domain] Cd Length: 124 Bit Score: 49.51 E-value: 3.13e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  13 HSLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFK-------------AMFTCGLLECNQREVILYDITA 79
Cdd:cd18195     1 HAGALLLQLNEQRLRGLFCDVTLIAGDTKFRAHRSVLAASSPYFRellssplplgaaaVAAAPGATQSPERVLELPGVKA 80

                          90
                  ....*....|....*..
gi 2462587650  80 ESVSVLLNYMYNAALEI 96
Cdd:cd18195    81 GVFSDVLNFIYSSRVAL 97

BTB_POZ_ZBTB34

cd18220

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

12-124

3.26e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349529 [Multi-domain] Cd Length: 120 Bit Score: 49.25 E-value: 3.26e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  12 QHSLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILydiTAESVSVLLNYMYN 91
Cdd:cd18220     7 EYSNTVLSQLNELRLQGKLCDIIVHIQGQPFRAHKAVLAASSPYFRDHSALSTMSGLSISVIK---NPNVFEQLLSFCYT 83

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2462587650  92 AALEINNANVQTVAMAAYFMQMEEVFSVCQKYM 124
Cdd:cd18220    84 GRMSLQLKDVVSFLTAASFLQMQCVIDKCTQIL 116

BACK_KLHL37_ENC1

cd18515

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also ...

131-225

4.40e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.

Pssm-ID: 350590 [Multi-domain] Cd Length: 98 Bit Score: 48.43 E-value: 4.40e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 131 SNCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLNISREESILDLVLRWVNHNKELRT 210
Cdd:cd18515     3 TNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTICKTEDFLQLPKDMVVQLLSSEELETEDERLVYEAAINWVNYDLKKRH 82

                          90
                  ....*....|....*
gi 2462587650 211 VHLVELLKQVRLELV 225
Cdd:cd18515    83 CYLSELLQTVRLALL 97

BTB2_POZ_RhoBTB

cd18300

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

29-128

4.80e-07

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349609 [Multi-domain] Cd Length: 108 Bit Score: 48.39 E-value: 4.80e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  29 EMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVLLNYMYNAALEInNANVQTVAM-- 106
Cdd:cd18300     8 LFSDVTFIVEDGTIPAHKALLVARCDVMAAMFGGNFRESSAKEVELPGVSKETFLALLEYLYTDQAPI-LEDGDCVGLiv 86

                          90       100
                  ....*....|....*....|..
gi 2462587650 107 AAYFMQMEEVFSVCQKYMMDHM 128
Cdd:cd18300    87 LANRLCLPRLVALCEQYIVKEL 108

BTB_POZ_ZBTB32_FAZF_TZFP

cd18218

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

13-124

8.27e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349527 [Multi-domain] Cd Length: 110 Bit Score: 48.01 E-value: 8.27e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  13 HSLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFT------CGLLEcnqrevilyDITAESVSVLL 86
Cdd:cd18218     1 HSDRLLHLAARLRPAGALCDTLITVGSQEFPAHSLVLAGASQQLGRQLTnpnpgqWCLGE---------GISPSTFKQLL 71

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2462587650  87 NYMYNAALEINNANVQTVAMAAYFMQMEEVFSVCQKYM 124
Cdd:cd18218    72 DFVYGESVEVQPGELRPLLEAARALEVESLEEACWRAL 109

NanM

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

325-445

9.30e-07

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

Pssm-ID: 442289 [Multi-domain] Cd Length: 277 Bit Score: 50.92 E-value: 9.30e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 325 TGVVMENNTIIVAGEASASklsrqknknveiyryhdRGNQFWEKLCT-AEFRELYALGSIHNDLYVIGGQMKIKNQylit 403
Cdd:COG3055   163 AAAVLPDGKILVIGGRNGS-----------------GFSNTWTTLAPlPTARAGHAAAVLGGKILVFGGESGFSDE---- 221

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2462587650 404 ncVDKYSVERDNWKRVSPLPLQLACHAVVTVNNKLYVIGGWT 445
Cdd:COG3055   222 --VEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVIGGET 261

BTB_POZ_ZBTB12

cd18203

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

13-129

9.56e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 12 (ZBTB12); ZBTB12, also called protein G10, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349512 [Multi-domain] Cd Length: 122 Bit Score: 47.95 E-value: 9.56e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  13 HSLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFtcgLLECNQREVILYDITAESVSVLLNYMYNA 92
Cdd:cd18203     8 HEAATLRNMNQLRSEERFCDVTIVADSLKFRGHKVVLAACSPFLRDQF---LLNPSSELQVSLMHSSRVVADLLLSCYTG 84

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2462587650  93 ALEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMD 129
Cdd:cd18203    85 ALEFSVRDIVNYLTAASYLQMEHVVEKCRGALSQFIE 121

BTB_POZ_CP190-like

cd18311

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...

17-113

9.59e-07

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster centrosomal protein 190kD (CP190) and similar proteins; CP190 is a large, multi-domain protein, first identified as a centrosome protein with oscillatory localization over the course of the cell cycle. It has an essential function in the nucleus as a chromatin insulator. It is known to associate with the nuclear matrix, components of the RNAi machinery, active promoters and borders of the repressive chromatin domains. CP190 contains an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349620 [Multi-domain] Cd Length: 110 Bit Score: 47.58 E-value: 9.59e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  17 LLNKIKNMKELAEMIDVVLTA-EGEKFPCHRLVLAAFSPYFKAM-FTCGLLecNQREVILYDITAESVSVLLNYMYNAAL 94
Cdd:cd18311     1 FLQRLQNLFNKTEYCDLTLQFrDNEQLKVHRLVLSACTDYFNVLeQTCEIV--DDTLIMPNELQADAVVPVINFMYTGQL 78

                          90
                  ....*....|....*....
gi 2462587650  95 EINNANVQTVAMAAYFMQM 113
Cdd:cd18311    79 EFEEKSYGKLLRTAKELNM 97

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

483-534

1.06e-06

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 45.68 E-value: 1.06e-06

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2462587650 483 YRFSTAVVNSEIYVLGGigcvgQDKGQvrkCLDVVEIYNPDGDFWREGPPMP 534
Cdd:pfam01344   3 SGAGVVVVGGKIYVIGG-----FDGNQ---SLNSVEVYDPETNTWSKLPSMP 46

muta_rot_YjhT

TIGR03547

mutatrotase, YjhT family; Members of this protein family contain multiple copies of the ...

363-586

1.11e-06

Pssm-ID: 274641 [Multi-domain] Cd Length: 346 Bit Score: 51.17 E-value: 1.11e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 363 NQFWEKLctAEF----RELYALGSIHNDLYVIGGQMKIKNQYLIT--NCVDKYSVERDNWKRV-SPLPLQLACHAVVTVN 435
Cdd:TIGR03547  40 SKGWQKI--ADFpggpRNQAVAAAIDGKLYVFGGIGKANSEGSPQvfDDVYRYDPKKNSWQKLdTRSPVGLLGASGFSLH 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 436 N-KLYVIGGWTPQM------DL----PDEEPDR---------------LSNKLLQYDPSQDQWSVRAPMKYSKyRFSTAV 489
Cdd:TIGR03547 118 NgQAYFTGGVNKNIfdgyfaDLsaadKDSEPKDkliaayfsqppedyfWNKNVLSYDPSTNQWRNLGENPFLG-TAGSAI 196

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 490 V--NSEIYVLGgigcvgqdkGQVRKCLDVVEIYNpdGDF------WREGPPMPSPLLSLRTNSTNA--GAVDGKLYVCGG 559
Cdd:TIGR03547 197 VhkGNKLLLIN---------GEIKPGLRTAEVKQ--YLFtggkleWNKLPPLPPPKSSSQEGLAGAfaGISNGVLLVAGG 265

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 2462587650 560 --FHGADR---------HEVISK----EILELDpwENQWNVV 586
Cdd:TIGR03547 266 anFPGAQEnykngklyaHEGLIKawssEVYALD--NGKWSKV 305

BTB_POZ_ZBTB21_ZNF295

cd18209

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

13-109

1.15e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349518 [Multi-domain] Cd Length: 112 Bit Score: 47.56 E-value: 1.15e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  13 HSLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGllECNQREVILYDIT-AESVSVLLNYMYN 91
Cdd:cd18209     1 HAISLLSALNEERLKGQLCDVLLIVGDQKFRAHKNVLAASSEYFQSLFTEK--ENESQSVFQLDFCePDAFENVLNYIYS 78

                          90
                  ....*....|....*...
gi 2462587650  92 AALEINNANVQTVAMAAY 109
Cdd:cd18209    79 SSLFVEKSSLAAVQELGY 96

BTB_POZ_BTBD1

cd18346

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

40-132

1.52e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 1 (BTBD1); BTBD1, also called Hepatitis C virus NS5A-transactivated protein 8 or HCV NS5A-transactivated protein 8, is a BTB-domain-containing Kelch-like protein that is expressed in skeletal muscle and interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. BTBD1 may serve as substrate-specific adaptor of an E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349655 [Multi-domain] Cd Length: 133 Bit Score: 47.75 E-value: 1.52e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  40 EKFPCHRLVLAAFSPYFKAMFTCGlLECNQREVILYDITAESVSVLLNYMYNAALEINNANVQTVAMAAYFMQMEEVFSV 119
Cdd:cd18346    42 QRIPAHRFVLAAGSAVFDAMFNGG-MATTSAEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAH 120

                          90
                  ....*....|...
gi 2462587650 120 CQKYMMDHMDASN 132
Cdd:cd18346   121 CVEFLTKHLRADN 133

BTB_POZ_ZBTB14

cd18204

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

16-122

2.37e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349513 [Multi-domain] Cd Length: 114 Bit Score: 46.95 E-value: 2.37e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  16 NLLNKIKNMKEL-AEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTcgLLECNQREVILYD-ITAESVSVLLNYMYNAA 93
Cdd:cd18204     3 TVFLKTLNEQRLeGEFCDIAIVVEDVKFRAHRCVLAACSTYFKKLFK--KLEVDSSSVIEIDfLRSDIFEEVLNYMYTAK 80

                          90       100
                  ....*....|....*....|....*....
gi 2462587650  94 LEINNANVQTVAMAAYFMQMEEVFSVCQK 122
Cdd:cd18204    81 ISVKKEDVNLMMSSGQILGIRFLDKLCSQ 109

BTB_POZ_ZBTB24_ZNF450

cd18212

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

13-116

2.44e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349521 [Multi-domain] Cd Length: 118 Bit Score: 46.71 E-value: 2.44e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  13 HSLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTcGLLECNQREVILYDITAESVSVLLNYMYNA 92
Cdd:cd18212     6 HKDTVLTNFEEQRKKDFLCDITLIVENVQFRAHKALLAASSEYFSMMFA-DEGEVGQSIYMLEGMVAETFGALLEFIYTG 84

                          90       100
                  ....*....|....*....|....
gi 2462587650  93 ALEINNANVQTVAMAAYFMQMEEV 116
Cdd:cd18212    85 CLQVGEKSLEQILATAQFLKVNDL 108

BTB_POZ_ZBTB20_DPZF

cd18208

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

11-122

2.63e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349517 [Multi-domain] Cd Length: 117 Bit Score: 46.60 E-value: 2.63e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  11 YQHSLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVilydITAESVSVLLNYMY 90
Cdd:cd18208     6 HNFSNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEIPSV----VSVQSVQKLIDFMY 81

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2462587650  91 NAALEINNANVQTVAMAAYFMQMEEVFSVCQK 122
Cdd:cd18208    82 SGVLRVSQSEALQILTAASILQIKTVIDECTR 113

BTB2_POZ_IBtk

cd18302

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

29-90

3.35e-06

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349611 [Multi-domain] Cd Length: 113 Bit Score: 46.20 E-value: 3.35e-06

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462587650  29 EMIDVVLTAE-GEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVLLNYMY 90
Cdd:cd18302     4 DLYDVTIVSEdGKEFPCHKCVLVARLEYFHSMLSSSWIEASSCSALTMPIPSDILEIILDYLY 66

BTB_POZ_ARIA_plant

cd18352

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...

28-108

5.42e-06

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349661 [Multi-domain] Cd Length: 116 Bit Score: 45.93 E-value: 5.42e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  28 AEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVLLNYMYNAALEINNANVQTVAMA 107
Cdd:cd18352    11 ATLSDVTFLVEGRRFYAHRIALLASSDAFRAMFDGGYREKEARDIEIPNIRWEVFELMMRFIYTGSVDITNDIAKDLLRA 90


                  .
gi 2462587650 108 A 108
Cdd:cd18352    91 A 91

BTB_POZ_BACH

cd18955

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

32-120

9.71e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349736 [Multi-domain] Cd Length: 94 Bit Score: 44.38 E-value: 9.71e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  32 DVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCgllECNQREVILY--DITAESVSVLLNYMYNAALEINNANVQTVAMAAY 109
Cdd:cd18955     3 DVTIVVEDQRFRAHRAVLAACSDYFLSRVVG---QTDGDLVITLpeEVTVKGFEPLLQFAYTAKLLLSKENVLEVCRCAE 79

                          90
                  ....*....|.
gi 2462587650 110 FMQMEEVFSVC 120
Cdd:cd18955    80 FLGVHNIEKAC 90

BTB_POZ_SPOPL

cd18343

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

17-132

9.94e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349652 [Multi-domain] Cd Length: 123 Bit Score: 45.38 E-value: 9.94e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  17 LLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVLLNYMYNAALEI 96
Cdd:cd18343     8 LAEDLGNLWENSRFTDCSLFVGGQEFKAHKSILAARSPVFNAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGKAPN 87

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2462587650  97 NNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDASN 132
Cdd:cd18343    88 LDKMADNLLAAADKYALERLKVMCEEALCNNLSVEN 123

BTB_POZ_BTBD1_2

cd18281

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

40-132

1.02e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349590 [Multi-domain] Cd Length: 127 Bit Score: 45.12 E-value: 1.02e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  40 EKFPCHRLVLAAFSPYFKAMFTCGLLECNQrEVILYDITAESVSVLLNYMYNAALEINNANVQTVAMAAYFMQMEEVFSV 119
Cdd:cd18281    36 QRIPAHKFVLSIGSAVFDAMFNGGMATTSA-EIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALESA 114

                          90
                  ....*....|...
gi 2462587650 120 CQKYMMDHMDASN 132
Cdd:cd18281   115 CVEFLKKNLSSDN 127

BTB_POZ_roadkill-like

cd18345

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

17-90

1.04e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349654 [Multi-domain] Cd Length: 121 Bit Score: 45.22 E-value: 1.04e-05

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462587650  17 LLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVLLNYMY 90
Cdd:cd18345     5 LSDDLGLLFERSAFSDVTLCVGGREFQAHKAILAARSPVFNAMFEHEMEERKQNRVEITDVDHEVMREMLRFIY 78

BTB_POZ_SPOP-like

cd18279

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

23-90

1.06e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349588 [Multi-domain] Cd Length: 120 Bit Score: 45.21 E-value: 1.06e-05

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462587650  23 NMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVLLNYMY 90
Cdd:cd18279    11 NLWENSRFTDCCLCVGGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIY 78

BTB_POZ_ZBTB41

cd18226

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

12-124

1.13e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349535 [Multi-domain] Cd Length: 114 Bit Score: 44.79 E-value: 1.13e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  12 QHSLNLLNKIKNMK-ELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTcgllECNQREVILYDITAESV-SVLLNYM 89
Cdd:cd18226     3 QYNKNLLKYLNDDRqKQSSFCDLVITVEGKEFSAHKVVVAVGSSYFHACLS----KNPNTDAVTLDHVSYSVfQHLLEFL 78

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2462587650  90 YNAALEINNANVQTVAMAAYFMQMEEVFSVCQKYM 124
Cdd:cd18226    79 YTSEFFVYENEIPLVLEAAKFLDIIDAVKLLTNEA 113

BTB_POZ_ZBTB25_ZNF46_KUP

cd18213

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

13-90

1.32e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25); ZBTB25, also called zinc finger protein 46 (ZNF46) or zinc finger protein KUP, is a transcription repressor that facilitates viral RNA transcription and replication. It interacts with viral RNA-dependent RNA polymerase (RdRp) proteins and modulates their transcription activity. It also functions as a viral RNA-binding protein, binding preferentially to the U-rich sequence within 5' UTR of vRNA. ZBTB25 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349522 [Multi-domain] Cd Length: 128 Bit Score: 44.89 E-value: 1.32e-05

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462587650  13 HSLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVIlyDITAESVSVLLNYMY 90
Cdd:cd18213     4 HSLVLLQQLNMQREFGFLCDCTVAIGDVYFKAHRAVLAAFSNYFKMIFIHQSSECIKIQPT--DIQPDIFSYLLHIMY 79

BTB_POZ_KBTBD11

cd18275

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

32-113

1.37e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349584 [Multi-domain] Cd Length: 104 Bit Score: 44.40 E-value: 1.37e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  32 DVVLTAEGEKFPCHRLVLAAFSPYFKAMFTcgllecnqREVI-LYDITAESVSVLLNYMYNAALEINNANVQTVAMAAYF 110
Cdd:cd18275     6 DLVIEVSGQRIRAHKSVLAAKSDYFRARLS--------RDILkVKGLSYATLRLLVDYVYSGRMAVSKDNVVEVVAGARF 77


                  ...
gi 2462587650 111 MQM 113
Cdd:cd18275    78 LQM 80

BACK_NS1BP_IVNS1ABP

cd18502

BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); ...

128-220

1.47e-05

BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); NS1-BP, also called NS1-binding protein, or Aryl hydrocarbon receptor-associated protein 3, or IVNS1ABP, is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control.

Pssm-ID: 350577 Cd Length: 99 Bit Score: 44.15 E-value: 1.47e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 128 MDASNCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEIL-----EIEVhqflTLIKSDDLNISREESILDLVLRWV 202
Cdd:cd18502     1 LTPENCIGIRSFAGRMNDSELLQKVDSYIQENIEEVAESKEFLklprlQIEV----ILESNQELESINERKLCQLVLEWV 76

                          90
                  ....*....|....*...
gi 2462587650 203 NHNKELRTVHLVELLKQV 220
Cdd:cd18502    77 QRSIEEGGLDLDDLTEKV 94

BTB_POZ_BTBD11

cd18351

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-134

1.82e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 11 (BTBD11); BTBD11, also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11, is a BTB-domain-containing protein. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349660 [Multi-domain] Cd Length: 131 Bit Score: 44.58 E-value: 1.82e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  29 EMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFT---CGLLECNQREVILYDItaesVSVLLNYMY---NAALEINNANVQ 102
Cdd:cd18351    23 EMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSnkpSAENTCIEISYVKYHI----FQLVMQYLYcggTESLLIKNNEIM 98

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2462587650 103 TVAMAAYFMQMEEVFSVCQKYMMDHMDASNCL 134
Cdd:cd18351    99 ELLSAAKFFQLEALQRHCEIICAKSINTENCV 130

BTB_POZ_ZBTB16_PLZF

cd18205

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

13-124

2.01e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 16 (ZBTB16); ZBTB16 is also called promyelocytic leukemia zinc finger protein, zinc finger protein 145, or zinc finger protein PLZF. It is a DNA-binding transcription factor essential for undifferentiated cell maintenance. ZBTB16 also acts as a downstream transcriptional regulator of Osterix and can be useful as a late marker of osteoblastic differentiation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349514 [Multi-domain] Cd Length: 107 Bit Score: 43.87 E-value: 2.01e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  13 HSLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFtcgllECNQREVILYDITAESVSVLLNYMYNA 92
Cdd:cd18205     1 HPTGLLHKANQMRLAGTLCDVVIMVDSQEFHAHRTVLACTSKMFEILF-----HRNSQHYTLDFLSPKTFQQILEYAYTA 75

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2462587650  93 ALEINNANVQTVAMAAYFMQMEEVFSVCQKYM 124
Cdd:cd18205    76 TLQAKVEDLDDLLYAAEILEIEYLEEQCLKIL 107

BTB_POZ_ZBTB39

cd18224

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

13-120

2.06e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349533 [Multi-domain] Cd Length: 123 Bit Score: 44.44 E-value: 2.06e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  13 HSLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYdITAESVSVLLNYMYNA 92
Cdd:cd18224     9 HPNNLLKELNKCRLSETMCDVTIVVGNRSFAAHKAVLACAAGYFQKLFLSTELDVARTYVVDF-ITPANFEKVLSFIYTS 87

                          90       100
                  ....*....|....*....|....*...
gi 2462587650  93 ALEINNANVQTVAMAAYFMQMEEVFSVC 120
Cdd:cd18224    88 ELFTDLINVGVIYEVAEKLGMEDLLKAC 115

BTB2_POZ_LZTR1

cd18309

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

29-90

2.16e-05

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349618 [Multi-domain] Cd Length: 126 Bit Score: 44.30 E-value: 2.16e-05

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462587650  29 EMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDI--TAESVSVLLNYMY 90
Cdd:cd18309    19 DFCDITLLLDGHPIPAHKAILAARCSYFEAMFRSFMPEDNTVNISIGEMvpSRQAFDSLLRYIY 82

Kelch

Kelch domain;

494-552

2.66e-05

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 41.78 E-value: 2.66e-05

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462587650  494 IYVLGGigcvgQDKGQvrkCLDVVEIYNPDGDFWREGPPMPSPllslRTNSTnAGAVDG 552
Cdd:smart00612   2 IYVVGG-----FDGGQ---RLKSVEVYDPETNKWTPLPSMPTP----RSGHG-VAVING 47

BTB_POZ_ZBTB38_CIBZ

cd18223

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

13-92

3.36e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349532 [Multi-domain] Cd Length: 114 Bit Score: 43.62 E-value: 3.36e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  13 HSLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLeCNQREVI-LYDITAESVSVLLNYMYN 91
Cdd:cd18223     1 HSDTVLSCLNEQRIQGILCDVTIVVEDTKFKAHKNVLAASSLYFKNAFSSQEI-WISSHVLeLPDLKAEVFAEILNFIYS 79


                  .
gi 2462587650  92 A 92
Cdd:cd18223    80 S 80

BTB1_POZ_IBtk

cd18301

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

32-90

4.03e-05

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349610 [Multi-domain] Cd Length: 99 Bit Score: 42.66 E-value: 4.03e-05

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462587650  32 DVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLEC----NQREVILYDITAESVSVLLNYMY 90
Cdd:cd18301    20 DVVFQVGGKTFPAHKFILASRSDYFRKLFLSSLLTSedavGCDVVHIEKVPPEIFEQLLQFIY 82

BTB_POZ_ZBTB30_HIC2

cd18334

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

13-122

4.86e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349643 [Multi-domain] Cd Length: 120 Bit Score: 43.03 E-value: 4.86e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  13 HSLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMftcgLLECNqreVILYDITAESVSV---LLNYM 89
Cdd:cd18334     4 HAKQLLLQLNQQRAKGFLCDVIIVVENALFRAHKNILAASSMYFKSL----VLHDN---LINLDTDMVNPTVfrqILDFI 76

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2462587650  90 YNAAL----EINNANVQTVAMAAYFMQMEEVFSVCQK 122
Cdd:cd18334    77 YTGKLltsdQPGEQNFNALLTAASYLQLHDLAALCRK 113

BTB_POZ_BTBD14B_NAC1

cd18290

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

32-116

5.42e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349599 [Multi-domain] Cd Length: 123 Bit Score: 43.10 E-value: 5.42e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  32 DVVLTAEGEKFPCHRLVLAAFSPYFKAMFTcgllecNQREVILY---DITAESVSVLLNYMYNAALEINNANVQTVAMAA 108
Cdd:cd18290    29 DVSVVVKGHAFKAHRAVLAASSSYFRDLFN------SSRSAVVElpaAVQPQSFQQILSFCYTGRLSMNVGDQFLLMYTA 102


                  ....*...
gi 2462587650 109 YFMQMEEV 116
Cdd:cd18290   103 GFLQIQEI 110

PRK14131

N-acetylneuraminate epimerase;

416-559

5.67e-05

N-acetylneuraminate epimerase;

Pssm-ID: 237617 [Multi-domain] Cd Length: 376 Bit Score: 45.78 E-value: 5.67e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 416 WKRVSPLPLQLACHAV-VTVNNKLYVIGGwtpQMDLPDEEPDRLSNKLLQYDPSQDQWS---VRAPMKYSKYRfSTAVVN 491
Cdd:PRK14131   64 WTKIAAFPGGPREQAVaAFIDGKLYVFGG---IGKTNSEGSPQVFDDVYKYDPKTNSWQkldTRSPVGLAGHV-AVSLHN 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 492 SEIYVLGG------------IGCVGQDKGQVRKCLD--------------VVEIYNPDGDFWREGPPMPSpllslrtnST 545
Cdd:PRK14131  140 GKAYITGGvnknifdgyfedLAAAGKDKTPKDKINDayfdkkpedyffnkEVLSYDPSTNQWKNAGESPF--------LG 211

                         170
                  ....*....|....*...
gi 2462587650 546 NAGAV----DGKLYVCGG 559
Cdd:PRK14131  212 TAGSAvvikGNKLWLING 229

BTB_POZ_KLHL11

cd18241

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

37-133

6.57e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349550 [Multi-domain] Cd Length: 135 Bit Score: 43.31 E-value: 6.57e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  37 AEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAE------SVSVLLNYMYNAALEINNANVQTV-AMAAY 109
Cdd:cd18241    33 AGGREFRAHRSVLAAATEYFTPLLSGQFSESRSGRVEMRKWSSEpgpdpdTVEAVIQYMYTGRIRVSTGNVHEVlELADR 112

                          90       100
                  ....*....|....*....|....*.
gi 2462587650 110 FM--QMEEvfsVCQKYMMDHMDASNC 133
Cdd:cd18241   113 FLliRLKE---FCGEFLKKKLNLSNC 135

BTB_POZ_ZBTB33_KAISO

cd18219

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

12-94

6.90e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349528 [Multi-domain] Cd Length: 106 Bit Score: 42.51 E-value: 6.90e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  12 QHSLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCG--LLECNqreVILYDITAEsvsvLLNYM 89
Cdd:cd18219     3 QYSGSLLKSLNEQRGHGLFCDVTVIVEDRKFRAHKNILSASSTYFHQLFSVAgqVVELN---FIRADIFAE----ILNYI 75


                  ....*
gi 2462587650  90 YNAAL 94
Cdd:cd18219    76 YSSKI 80

BTB_POZ_BTBD3_6

cd18282

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

40-128

7.81e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349591 [Multi-domain] Cd Length: 108 Bit Score: 42.38 E-value: 7.81e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  40 EKFPCHRLVLAAFSPYFKAMFTCGLLEcNQREVILYDITAESVSVLLNYMYNAALEINNANVQTVAMAAyfmqmeevfsv 119
Cdd:cd18282    21 QRIPAHKYVLATGSSVFYAMFYGGLAE-NKNEIEIPDVEPAAFLNLLRYLYCDEIDLEPDTVLATLYAA----------- 88


                  ....*....
gi 2462587650 120 cQKYMMDHM 128
Cdd:cd18282    89 -KKYLVPHL 96

BTB1_POZ_BTBD7

cd18283

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

32-119

1.12e-04

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349592 [Multi-domain] Cd Length: 92 Bit Score: 41.16 E-value: 1.12e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  32 DVVLTAEGEKFPCHRLVLAAFSPYFKAMftcgLLEC-NQREVILYD-----ITAESVSVLLNYMYNAALEINNANVQTVA 105
Cdd:cd18283     4 DVDLVFQGTCFPVHRAILSARCPFFRDL----LSSSpGYGAEIPVDlptagIDVPMFSALLRYLYTGEFGSEDSRSQNLD 79

                          90
                  ....*....|....
gi 2462587650 106 MaayFMQMEEVFSV 119
Cdd:cd18283    80 V---LIQLSEEFGT 90

BTB1_POZ_ABTB1_BPOZ1

cd18295

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

21-96

1.19e-04

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349604 [Multi-domain] Cd Length: 119 Bit Score: 41.85 E-value: 1.19e-04

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462587650  21 IKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLecNQREVILYD--ITAESVSVLLNYMYNAALEI 96
Cdd:cd18295    10 LRRLLEQGSYSDVTFNVHGESFPAHRCILSARSPYFAEMFETKWK--DKREINLKHplVNPDAFRALLQYLYTGRLEI 85

BTB_POZ_ZBTB1

cd18192

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

13-113

1.35e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1); ZBTB1 acts as a transcriptional repressor that represses cAMP-responsive element (CRE)-mediated transcriptional activation. It also has a role in translesion DNA synthesis, and is essential for lymphocyte development. ZBTB1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349501 [Multi-domain] Cd Length: 114 Bit Score: 41.73 E-value: 1.35e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  13 HSLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVLLNYMYNA 92
Cdd:cd18192     4 HSSYVLQQLNNQREWGFLCDCCIAIDDIYFQAHKAVLAACSSYFRMMFINHQHTTAQLNLSNMKISAECFDLILQFMYLG 83

                          90       100
                  ....*....|....*....|.
gi 2462587650  93 ALEINNANVQTVAMAAYFMQM 113
Cdd:cd18192    84 KIMTAPSDFEQLKVAMNYLQL 104

BTB_POZ_ZBTB2

cd18193

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

13-94

1.52e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 2 (ZBTB2); ZBTB2 is a POZ domain Kruppel-like zinc finger (POK) family transcription factor acting as a potent repressor of the ARF-HDM2-p53-p21 pathway, which is important in cell cycle regulation. It represses transcription of the ARF, p53, and p21 genes, but activates the HDM2 gene. ZBTB2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349502 [Multi-domain] Cd Length: 115 Bit Score: 41.52 E-value: 1.52e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  13 HSLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVIlyDITAESVSVLLNYMYNA 92
Cdd:cd18193     4 HGLILLQQLNAQREFGFLCDCTVAIGDVYFKAHKSVLASFSNYFKMLFVHQTSECVRLKPT--DIQPDIFSYLLHLMYTG 81


                  ..
gi 2462587650  93 AL 94
Cdd:cd18193    82 KM 83

BTB_POZ_SPOP

cd18342

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

17-132

1.53e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349651 [Multi-domain] Cd Length: 125 Bit Score: 42.01 E-value: 1.53e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  17 LLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVLLNYMYNAALEI 96
Cdd:cd18342     9 LADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGKAPN 88

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2462587650  97 NNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDASN 132
Cdd:cd18342    89 LDKMADDLLAAADKYALERLKVMCEDALCSNLSVEN 124

BTB_POZ_BTBD2

cd18347

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

40-132

2.33e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349656 [Multi-domain] Cd Length: 127 Bit Score: 41.21 E-value: 2.33e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  40 EKFPCHRLVLAAFSPYFKAMFTCGlLECNQREVILYDITAESVSVLLNYMYNAALEINNANVQTVAMAAYFMQMEEVFSV 119
Cdd:cd18347    36 QRIPAHRFVLAVGSAVFDAMFNGG-MATTSTEIELPDVEPAAFLALLKFLYSDEVQIGPETVMTTLYTAKKYAVPALEAH 114

                          90
                  ....*....|...
gi 2462587650 120 CQKYMMDHMDASN 132
Cdd:cd18347   115 CVEFLKKNLRADN 127

BTB_POZ_ZBTB29_HIC1

cd18333

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

13-127

2.36e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349642 [Multi-domain] Cd Length: 121 Bit Score: 41.04 E-value: 2.36e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  13 HSLNLLNKIKNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMftcgLLECNqreviLYDITAESVS-----VLLN 87
Cdd:cd18333     4 HSRQLLLQLNTQRTKGFLCDVIIVVQNALFRAHKNILAASSVYLKSL----VVHDN-----LINLDHEMVSpgifrLILD 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2462587650  88 YMYNAAL----EINNANVQTVAMAAYFMQMEEVFSVCQKYMMDH 127
Cdd:cd18333    75 YIYTGRLsegdPGSEQNLGAVLAAASYLQIPDLVALCKKKLKRN 118

BTB_POZ_BTBD16

cd18291

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

32-132

2.85e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 16 (BTBD16); BTBD16 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349600 Cd Length: 114 Bit Score: 40.89 E-value: 2.85e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  32 DVVLTAEGEKFPCHRLVLaafspyFKAMFTCGLLEcnqREVILYDI-----TAESVSVLLNYMYNAALEINNANVQTVAM 106
Cdd:cd18291    14 DVVLECLGSFWELHSPYL------CKSETLAELLK---PVTISLNIndplvTKEAFAVALGNLYNSEVEVNVEDAVGVLA 84

                          90       100
                  ....*....|....*....|....*.
gi 2462587650 107 AAYFMQMEEVFSVCQKYMMDHMDASN 132
Cdd:cd18291    85 AAALLRFPTLFQKCVKVMISSISSST 110

Kelch_6

pfam13964

Kelch motif;

485-536

3.02e-04

Kelch motif;

Pssm-ID: 404790 [Multi-domain] Cd Length: 50 Bit Score: 38.86 E-value: 3.02e-04

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2462587650 485 FSTAVVNSEIYVLGGIGCVGQDkgqvrkcLDVVEIYNPDGDFWREGPPMPSP 536
Cdd:pfam13964   5 HSVVSVGGYIYVFGGYTNASPA-------LNKLEVYNPLTKSWEELPPLPTP 49

BACK_KLHL32_BKLHD5

cd18471

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also ...

128-225

3.30e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also termed BTB and kelch domain-containing protein 5 (BKLHD5), belongs to the KLHL family. Its function remains unclear. KLHL32 SNPs may be associated with body mass index in individuals of African ancestry.

Pssm-ID: 350546 [Multi-domain] Cd Length: 98 Bit Score: 40.27 E-value: 3.30e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650 128 MDASNCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEV--SLHEEILEIEVHQFLTLIKSDDLNISREESILDLVLRWVNHN 205
Cdd:cd18471     1 LNSFNYLDLYKLADLFNLTLLEEAVVDFLVKHLSELlkSHPEEVLALPYRLLREVLKSDRLTSLSEEQIWQLAVRWLEHN 80

                          90       100
                  ....*....|....*....|
gi 2462587650 206 keLRTVHLVELLKQVRLELV 225
Cdd:cd18471    81 --CRYQYMDELLQYVRFGLM 98

BTB_POZ_NPY3-like

cd18312

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...

25-115

4.19e-04

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana protein naked pins in YUC mutants 3 (NPY3), Root phototropism protein 3 (RPT3), and similar proteins; NPY3 may play an essential role in auxin-mediated organogenesis and in root gravitropic responses in Arabidopsis. RPT3 is a signal transducer of the phototropic response and photo-induced movements. It is necessary for root and hypocotyl phototropisms, but not for the regulation of stomata opening. Proteins in this subfamily contain an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349621 [Multi-domain] Cd Length: 105 Bit Score: 40.01 E-value: 4.19e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587650  25 KELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMftCGLLECNQREVI-LYDIT--AESVSVLLNYMYNAALEINNANV 101
Cdd:cd18312     4 RDTGEPSDITVRVGNTTFHLHKFPLCSKSGYFKRL--ASSSSESDPSEIeLNDFPggAEAFELVAKFCYGMPINLTATNV 81

                          90
                  ....*....|....
gi 2462587650 102 QTVAMAAYFMQMEE 115
Cdd:cd18312    82 VGLRCAAEYLEMTE 95

Kelch

Kelch domain;

387-436

6.51e-04

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 37.92 E-value: 6.51e-04

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 2462587650  387 LYVIGGQMKikNQYLitNCVDKYSVERDNWKRVSPLPLQLACHAVVTVNN 436
Cdd:smart00612   2 IYVVGGFDG--GQRL--KSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

547-587

7.91e-04

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 37.59 E-value: 7.91e-04

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2462587650 547 AGAVDGKLYVCGGFHGADRHEVIskEIleLDPWENQWNVVA 587
Cdd:pfam01344   7 VVVVGGKIYVIGGFDGNQSLNSV--EV--YDPETNTWSKLP 43

Kelch_1