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Conserved domains on  [gi|2462593137|ref|XP_054204087|]
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interleukin-17 receptor C isoform X15 [Homo sapiens]

Protein Classification

SEFIR domain-containing protein; toll-interleukin-resistance domain-containing protein( domain architecture ID 10633270)

SEFIR domain-containing protein may function as signaling components of Toll/IL-1R-similar pathways and the SEFIR domain mediates physical protein-protein interactions between pathway components| toll-interleukin-resistance (TIR) domain-containing protein may act as a disease resistance protein in plant

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IL17_R_N pfam15037
Interleukin-17 receptor extracellular region; This domain is found at the N-terminus ...
 142-502 0e+00

Interleukin-17 receptor extracellular region; This domain is found at the N-terminus (extracellular region) of interleukin-17 receptor C and Interleukin-17 receptor E. This is the presumed ligand-binding domain. Human putative interleukin-17 receptor E-like consists only of this domain.


:

Pssm-ID: 464460  Cd Length: 388  Bit Score: 605.70  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462593137 142 VLRCQKETDCDLCLRVAVHLAVHGHWEEPEDEEKFGGAADLGVEEPRNASLQAQVVLSFQAYPTARCVLLEVQVPAALVQ 221
Cdd:pfam15037   1 VLRCRMETDCDLCVRVVVHLAVQKHWEEPEESEKFGGARRHEMPAPRNASLQAQVVLSFQAYPIARCVLLEVEVPAALVR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462593137 222 FGQSVGSVVYDCFEAALGSEVRIWSYTQPRYEKELNHTQQLP---------------ALPWLNVSADGDNVHLVLNVSEE 286
Cdd:pfam15037  81 PGQSVGSVVFDCFEAALGAEVRIWSYTQPRYQKELNHTQQLPdcraievevsvrscwALPWLNLSAPGDNVQLVLDVSEE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462593137 287 QHFGLSLYWNQ------------TGPQIITLNHTDLVPCLCIQVWPLEPDSVRTNICPFREDPRAHQNLWQAARLRLLTL 354
Cdd:pfam15037 161 QRFGLLYWWQVqgppkprwqknlTGPQTITLNHTDLVPCLCIQAWPLEEDTVRTKKCPFQEDPRAHSNLWKSARLTLLSQ 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462593137 355 QSWLLDAPCSLPAEAALCWRAPGGDPCQPLVPPLSWENVTVDKVLEFPLLKGHPNLCVQVNSSEKLQLQECLWADSLGPL 434
Cdd:pfam15037 241 HSWMVDAPCPLKAEAALCWRAPGGTLCQPLPPPLPRENVTVNGWYVLPLLDLHPNLCVQVSSGEKSQLQECPWADSLGPL 320

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462593137 435 KDDVLLLETRGPQDNRSLCALEPSGCTSLPSKASTRAARLGEYLLQDLQSGQCLQLWDDDLGALWACP 502
Cdd:pfam15037 321 QDDMLLLETSGPQHNTSSCALEHSGCTPLPSVAQTRAARLGEQLLQDLQSGQCVQLWRDDVGFLWACP 388
SEFIR pfam08357
SEFIR domain; This family comprises IL17 receptors (IL17Rs) and SEF proteins. The latter are ...
 549-696 1.66e-45

SEFIR domain; This family comprises IL17 receptors (IL17Rs) and SEF proteins. The latter are feedback inhibitors of FGF signalling and are also thought to be receptors. Due to its similarity to the TIR domain (pfam01582), the SEFIR region is thought to be involved in homotypic interactions with other SEFIR/TIR-domain-containing proteins. Thus, SEFs and IL17Rs may be involved in TOLL/IL1R-like signalling pathways.


:

Pssm-ID: 254756  Cd Length: 150  Bit Score: 159.48  E-value: 1.66e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462593137 549 YSADDSGFERLVGALASALCQL-PLRVAVDLWSRRELSAQGPVAWFHAQrrqtLQEGGVVVLLFSPGAVALCSEWLQDGV 627
Cdd:pfam08357   7 YSSDSALHTEVVLKFAEFLQDYcGCEVALDLWELNEIAEIGPVAWLERQ----IQEADKVIIVCSKGAKAFCDKKADKRK 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462593137 628 SGPGAHGPHDAFRASLSCVLPDFLQGRAPGSYVGACFdRLLHPDAVPALFRTVPVFTLPSQLPDFLGAL 696
Cdd:pfam08357  83 GGVGTESQHDLFIPALSLILRDFKQSAALRKYLVVYF-GYADKKDVPTILRVLPKYSLMDQLPQLLAEL 150
 
Name Accession Description Interval E-value
IL17_R_N pfam15037
Interleukin-17 receptor extracellular region; This domain is found at the N-terminus ...
 142-502 0e+00

Interleukin-17 receptor extracellular region; This domain is found at the N-terminus (extracellular region) of interleukin-17 receptor C and Interleukin-17 receptor E. This is the presumed ligand-binding domain. Human putative interleukin-17 receptor E-like consists only of this domain.


Pssm-ID: 464460  Cd Length: 388  Bit Score: 605.70  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462593137 142 VLRCQKETDCDLCLRVAVHLAVHGHWEEPEDEEKFGGAADLGVEEPRNASLQAQVVLSFQAYPTARCVLLEVQVPAALVQ 221
Cdd:pfam15037   1 VLRCRMETDCDLCVRVVVHLAVQKHWEEPEESEKFGGARRHEMPAPRNASLQAQVVLSFQAYPIARCVLLEVEVPAALVR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462593137 222 FGQSVGSVVYDCFEAALGSEVRIWSYTQPRYEKELNHTQQLP---------------ALPWLNVSADGDNVHLVLNVSEE 286
Cdd:pfam15037  81 PGQSVGSVVFDCFEAALGAEVRIWSYTQPRYQKELNHTQQLPdcraievevsvrscwALPWLNLSAPGDNVQLVLDVSEE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462593137 287 QHFGLSLYWNQ------------TGPQIITLNHTDLVPCLCIQVWPLEPDSVRTNICPFREDPRAHQNLWQAARLRLLTL 354
Cdd:pfam15037 161 QRFGLLYWWQVqgppkprwqknlTGPQTITLNHTDLVPCLCIQAWPLEEDTVRTKKCPFQEDPRAHSNLWKSARLTLLSQ 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462593137 355 QSWLLDAPCSLPAEAALCWRAPGGDPCQPLVPPLSWENVTVDKVLEFPLLKGHPNLCVQVNSSEKLQLQECLWADSLGPL 434
Cdd:pfam15037 241 HSWMVDAPCPLKAEAALCWRAPGGTLCQPLPPPLPRENVTVNGWYVLPLLDLHPNLCVQVSSGEKSQLQECPWADSLGPL 320

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462593137 435 KDDVLLLETRGPQDNRSLCALEPSGCTSLPSKASTRAARLGEYLLQDLQSGQCLQLWDDDLGALWACP 502
Cdd:pfam15037 321 QDDMLLLETSGPQHNTSSCALEHSGCTPLPSVAQTRAARLGEQLLQDLQSGQCVQLWRDDVGFLWACP 388
SEFIR pfam08357
SEFIR domain; This family comprises IL17 receptors (IL17Rs) and SEF proteins. The latter are ...
 549-696 1.66e-45

SEFIR domain; This family comprises IL17 receptors (IL17Rs) and SEF proteins. The latter are feedback inhibitors of FGF signalling and are also thought to be receptors. Due to its similarity to the TIR domain (pfam01582), the SEFIR region is thought to be involved in homotypic interactions with other SEFIR/TIR-domain-containing proteins. Thus, SEFs and IL17Rs may be involved in TOLL/IL1R-like signalling pathways.


Pssm-ID: 254756  Cd Length: 150  Bit Score: 159.48  E-value: 1.66e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462593137 549 YSADDSGFERLVGALASALCQL-PLRVAVDLWSRRELSAQGPVAWFHAQrrqtLQEGGVVVLLFSPGAVALCSEWLQDGV 627
Cdd:pfam08357   7 YSSDSALHTEVVLKFAEFLQDYcGCEVALDLWELNEIAEIGPVAWLERQ----IQEADKVIIVCSKGAKAFCDKKADKRK 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462593137 628 SGPGAHGPHDAFRASLSCVLPDFLQGRAPGSYVGACFdRLLHPDAVPALFRTVPVFTLPSQLPDFLGAL 696
Cdd:pfam08357  83 GGVGTESQHDLFIPALSLILRDFKQSAALRKYLVVYF-GYADKKDVPTILRVLPKYSLMDQLPQLLAEL 150
 
Name Accession Description Interval E-value
IL17_R_N pfam15037
Interleukin-17 receptor extracellular region; This domain is found at the N-terminus ...
 142-502 0e+00

Interleukin-17 receptor extracellular region; This domain is found at the N-terminus (extracellular region) of interleukin-17 receptor C and Interleukin-17 receptor E. This is the presumed ligand-binding domain. Human putative interleukin-17 receptor E-like consists only of this domain.


Pssm-ID: 464460  Cd Length: 388  Bit Score: 605.70  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462593137 142 VLRCQKETDCDLCLRVAVHLAVHGHWEEPEDEEKFGGAADLGVEEPRNASLQAQVVLSFQAYPTARCVLLEVQVPAALVQ 221
Cdd:pfam15037   1 VLRCRMETDCDLCVRVVVHLAVQKHWEEPEESEKFGGARRHEMPAPRNASLQAQVVLSFQAYPIARCVLLEVEVPAALVR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462593137 222 FGQSVGSVVYDCFEAALGSEVRIWSYTQPRYEKELNHTQQLP---------------ALPWLNVSADGDNVHLVLNVSEE 286
Cdd:pfam15037  81 PGQSVGSVVFDCFEAALGAEVRIWSYTQPRYQKELNHTQQLPdcraievevsvrscwALPWLNLSAPGDNVQLVLDVSEE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462593137 287 QHFGLSLYWNQ------------TGPQIITLNHTDLVPCLCIQVWPLEPDSVRTNICPFREDPRAHQNLWQAARLRLLTL 354
Cdd:pfam15037 161 QRFGLLYWWQVqgppkprwqknlTGPQTITLNHTDLVPCLCIQAWPLEEDTVRTKKCPFQEDPRAHSNLWKSARLTLLSQ 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462593137 355 QSWLLDAPCSLPAEAALCWRAPGGDPCQPLVPPLSWENVTVDKVLEFPLLKGHPNLCVQVNSSEKLQLQECLWADSLGPL 434
Cdd:pfam15037 241 HSWMVDAPCPLKAEAALCWRAPGGTLCQPLPPPLPRENVTVNGWYVLPLLDLHPNLCVQVSSGEKSQLQECPWADSLGPL 320

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462593137 435 KDDVLLLETRGPQDNRSLCALEPSGCTSLPSKASTRAARLGEYLLQDLQSGQCLQLWDDDLGALWACP 502
Cdd:pfam15037 321 QDDMLLLETSGPQHNTSSCALEHSGCTPLPSVAQTRAARLGEQLLQDLQSGQCVQLWRDDVGFLWACP 388
SEFIR pfam08357
SEFIR domain; This family comprises IL17 receptors (IL17Rs) and SEF proteins. The latter are ...
 549-696 1.66e-45

SEFIR domain; This family comprises IL17 receptors (IL17Rs) and SEF proteins. The latter are feedback inhibitors of FGF signalling and are also thought to be receptors. Due to its similarity to the TIR domain (pfam01582), the SEFIR region is thought to be involved in homotypic interactions with other SEFIR/TIR-domain-containing proteins. Thus, SEFs and IL17Rs may be involved in TOLL/IL1R-like signalling pathways.


Pssm-ID: 254756  Cd Length: 150  Bit Score: 159.48  E-value: 1.66e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462593137 549 YSADDSGFERLVGALASALCQL-PLRVAVDLWSRRELSAQGPVAWFHAQrrqtLQEGGVVVLLFSPGAVALCSEWLQDGV 627
Cdd:pfam08357   7 YSSDSALHTEVVLKFAEFLQDYcGCEVALDLWELNEIAEIGPVAWLERQ----IQEADKVIIVCSKGAKAFCDKKADKRK 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462593137 628 SGPGAHGPHDAFRASLSCVLPDFLQGRAPGSYVGACFdRLLHPDAVPALFRTVPVFTLPSQLPDFLGAL 696
Cdd:pfam08357  83 GGVGTESQHDLFIPALSLILRDFKQSAALRKYLVVYF-GYADKKDVPTILRVLPKYSLMDQLPQLLAEL 150
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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