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Conserved domains on  [gi|2462597111|ref|XP_054205955|]
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mitochondrial proton/calcium exchanger protein isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LETM1_RBD pfam07766
LETM1-like, RBD; Members of this entry are inner mitochondrial membrane proteins which play a ...
 11-242 2.65e-107

LETM1-like, RBD; Members of this entry are inner mitochondrial membrane proteins which play a role in potassium and hydrogen ion exchange. Deletion of LETM1 is thought to be involved in the development of Wolf-Hirschhorn syndrome in humans. This entry represents the ribosome-binding domain (RBD) of LETM1/MDM38 proteins.


:

Pssm-ID: 462258 [Multi-domain]  Cd Length: 229  Bit Score: 320.59  E-value: 2.65e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462597111  11 LTRRERRQFLRICADLFRLVPFLVFVVVPFMEFLLPVAVKLFPNMLPSTFETQSLKEERLKKELRVKLELAKFLQDTIEE 90
Cdd:pfam07766   1 LTRREREQLRRTTRDLFRLVPFSVFIIVPFAELLLPVLLKLFPNLLPSTFWSKKQKEEKLKKRLKARLEVAKFLQETVEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462597111  91 MALKNKAAKgsaTKDFSVFFQKIRETGERPSNEEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTM 170
Cdd:pfam07766  81 SLSDETTEL---KEEFKEFFKKVRSGGEPPSNEEILKVAKLFKDDLTLDNLSRPQLVALCKYMNLTPFGTDNLLRYRLRH 157

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462597111 171 RLRSIKADDKLIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHLHQEIPTSLLILSRAMY 242
Cdd:pfam07766 158 KLLEIKRDDRAIAREGVDSLSLEELQSACYSRGIRPLGLSEERLREWLQQWLDLSLNLKVPSSLLLLSRAVL 229
Dockerin_like super family cl21530
Dockerin repeat domains and domains resembling dockerin repeats; Dockerins are modules in the ...
 463-508 9.56e-03

Dockerin repeat domains and domains resembling dockerin repeats; Dockerins are modules in the cellulosome complex that often anchor catalytic subunits by binding to cohesin domains of scaffolding proteins. Three types of dockerins and their corresponding cohesin have been described in the literature. This alignment models two consecutive dockerin repeats, the functional unit.


The actual alignment was detected with superfamily member cd14254:

Pssm-ID: 277547  Cd Length: 54  Bit Score: 34.49  E-value: 9.56e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2462597111 463 GENVISVAELINAMKqvkHIPESKLTSLAAALDENKDGKVNIDDLV 508
Cdd:cd14254     5 GDGVVDIADLALVSQ---HFGKTSDAGYVPAADLNGDGVIDAADLA 47
 
Name Accession Description Interval E-value
LETM1_RBD pfam07766
LETM1-like, RBD; Members of this entry are inner mitochondrial membrane proteins which play a ...
 11-242 2.65e-107

LETM1-like, RBD; Members of this entry are inner mitochondrial membrane proteins which play a role in potassium and hydrogen ion exchange. Deletion of LETM1 is thought to be involved in the development of Wolf-Hirschhorn syndrome in humans. This entry represents the ribosome-binding domain (RBD) of LETM1/MDM38 proteins.


Pssm-ID: 462258 [Multi-domain]  Cd Length: 229  Bit Score: 320.59  E-value: 2.65e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462597111  11 LTRRERRQFLRICADLFRLVPFLVFVVVPFMEFLLPVAVKLFPNMLPSTFETQSLKEERLKKELRVKLELAKFLQDTIEE 90
Cdd:pfam07766   1 LTRREREQLRRTTRDLFRLVPFSVFIIVPFAELLLPVLLKLFPNLLPSTFWSKKQKEEKLKKRLKARLEVAKFLQETVEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462597111  91 MALKNKAAKgsaTKDFSVFFQKIRETGERPSNEEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTM 170
Cdd:pfam07766  81 SLSDETTEL---KEEFKEFFKKVRSGGEPPSNEEILKVAKLFKDDLTLDNLSRPQLVALCKYMNLTPFGTDNLLRYRLRH 157

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462597111 171 RLRSIKADDKLIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHLHQEIPTSLLILSRAMY 242
Cdd:pfam07766 158 KLLEIKRDDRAIAREGVDSLSLEELQSACYSRGIRPLGLSEERLREWLQQWLDLSLNLKVPSSLLLLSRAVL 229
Dockerin_II cd14254
Type II dockerin repeat domain; Bacterial cohesin domains bind to a complementary protein ...
 463-508 9.56e-03

Type II dockerin repeat domain; Bacterial cohesin domains bind to a complementary protein domain named dockerin, and this interaction is required for the formation of the cellulosome, a cellulose-degrading complex. The cellulosome consists of scaffoldin, a noncatalytic scaffolding polypeptide, that comprises repeating cohesion modules and a single carbohydrate-binding module (CBM). Specific calcium-dependent interactions between cohesins and dockerins appear to be essential for cellulosome assembly. This subfamily represents type II dockerins, which are responsible for mediating attachment of the cellulosome complex to the bacterial cell wall.


Pssm-ID: 271213  Cd Length: 54  Bit Score: 34.49  E-value: 9.56e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2462597111 463 GENVISVAELINAMKqvkHIPESKLTSLAAALDENKDGKVNIDDLV 508
Cdd:cd14254     5 GDGVVDIADLALVSQ---HFGKTSDAGYVPAADLNGDGVIDAADLA 47
 
Name Accession Description Interval E-value
LETM1_RBD pfam07766
LETM1-like, RBD; Members of this entry are inner mitochondrial membrane proteins which play a ...
 11-242 2.65e-107

LETM1-like, RBD; Members of this entry are inner mitochondrial membrane proteins which play a role in potassium and hydrogen ion exchange. Deletion of LETM1 is thought to be involved in the development of Wolf-Hirschhorn syndrome in humans. This entry represents the ribosome-binding domain (RBD) of LETM1/MDM38 proteins.


Pssm-ID: 462258 [Multi-domain]  Cd Length: 229  Bit Score: 320.59  E-value: 2.65e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462597111  11 LTRRERRQFLRICADLFRLVPFLVFVVVPFMEFLLPVAVKLFPNMLPSTFETQSLKEERLKKELRVKLELAKFLQDTIEE 90
Cdd:pfam07766   1 LTRREREQLRRTTRDLFRLVPFSVFIIVPFAELLLPVLLKLFPNLLPSTFWSKKQKEEKLKKRLKARLEVAKFLQETVEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462597111  91 MALKNKAAKgsaTKDFSVFFQKIRETGERPSNEEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTM 170
Cdd:pfam07766  81 SLSDETTEL---KEEFKEFFKKVRSGGEPPSNEEILKVAKLFKDDLTLDNLSRPQLVALCKYMNLTPFGTDNLLRYRLRH 157

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462597111 171 RLRSIKADDKLIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHLHQEIPTSLLILSRAMY 242
Cdd:pfam07766 158 KLLEIKRDDRAIAREGVDSLSLEELQSACYSRGIRPLGLSEERLREWLQQWLDLSLNLKVPSSLLLLSRAVL 229
Dockerin_II cd14254
Type II dockerin repeat domain; Bacterial cohesin domains bind to a complementary protein ...
 463-508 9.56e-03

Type II dockerin repeat domain; Bacterial cohesin domains bind to a complementary protein domain named dockerin, and this interaction is required for the formation of the cellulosome, a cellulose-degrading complex. The cellulosome consists of scaffoldin, a noncatalytic scaffolding polypeptide, that comprises repeating cohesion modules and a single carbohydrate-binding module (CBM). Specific calcium-dependent interactions between cohesins and dockerins appear to be essential for cellulosome assembly. This subfamily represents type II dockerins, which are responsible for mediating attachment of the cellulosome complex to the bacterial cell wall.


Pssm-ID: 271213  Cd Length: 54  Bit Score: 34.49  E-value: 9.56e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2462597111 463 GENVISVAELINAMKqvkHIPESKLTSLAAALDENKDGKVNIDDLV 508
Cdd:cd14254     5 GDGVVDIADLALVSQ---HFGKTSDAGYVPAADLNGDGVIDAADLA 47
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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