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Conserved domains on  [gi|2462607647|ref|XP_054211018|]
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WD repeat-containing protein 27 isoform X6 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 13234759)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
545-837 4.99e-32

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 129.26  E-value: 4.99e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462607647 545 RVCCIQYSGDGQWLACGLANHLLLVFDASLTGTPAVFSGHDGAVNAVCWSQDRRWLLSAARDGTLRMWSAR-GAELALLL 623
Cdd:COG2319   122 AVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLT 201

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462607647 624 GKdmfSKPIQSAqfyyidAF-----ILLSSGPEFQLLRYHIDTckdeikrykqkskSKLICRLST-TGAVdmTSLSAVND 697
Cdd:COG2319   202 GH---TGAVRSV------AFspdgkLLASGSADGTVRLWDLAT-------------GKLLRTLTGhSGSV--RSVAFSPD 257

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462607647 698 fySHIVLAAGRNRTVEVFDLNAGcSAAVIAEAHSRPVHQICqnkgssFTtqqPQayNLFLTTAIGDGM-RLWDLRTLRCE 776
Cdd:COG2319   258 --GRLLASGSADGTVRLWDLATG-ELLRTLTGHSGGVNSVA------FS---PD--GKLLASGSDDGTvRLWDLATGKLL 323

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462607647 777 RHFEGHptRGYPCGIAFSPCGRFAACGAEDRHAYVYEMGSSTFSHRLAGHTDTVTGVAFNP 837
Cdd:COG2319   324 RTLTGH--TGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP 382
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 48-266 1.79e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 77.76  E-value: 1.79e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462607647  48 DGTeLCIWNTKDPShQLLILRGHHQPITAMAFGnkVNPLLICSASLD-YVIMWNLDECRE-KVLQGLVprgtvmgsllGK 125
Cdd:cd00200   114 DKT-IKVWDVETGK-CLTTLRGHTDWVNSVAFS--PDGTFVASSSQDgTIKLWDLRTGKCvATLTGHT----------GE 179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462607647 126 VLCLQLSPDDHVVAVCAGNK-IFMLDIeqrfsvtyierpdvnnrhkvppptflhtfsQTQAVRAELQGHLGPVTAVEFCP 204
Cdd:cd00200   180 VNSVAFSPDGEKLLSSSSDGtIKLWDL------------------------------STGKCLGTLRGHENGVNSVAFSP 229

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462607647 205 WRaGTLISASEDRSFKVWDHCTGSLIYsssVLSAY--PLLSLFIDAESRQLVTGCADGQLWIFS 266
Cdd:cd00200   230 DG-YLLASGSEDGTIRVWDLRTGECVQ---TLSGHtnSVTSLAWSPDGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
545-837 4.99e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 129.26  E-value: 4.99e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462607647 545 RVCCIQYSGDGQWLACGLANHLLLVFDASLTGTPAVFSGHDGAVNAVCWSQDRRWLLSAARDGTLRMWSAR-GAELALLL 623
Cdd:COG2319   122 AVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLT 201

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462607647 624 GKdmfSKPIQSAqfyyidAF-----ILLSSGPEFQLLRYHIDTckdeikrykqkskSKLICRLST-TGAVdmTSLSAVND 697
Cdd:COG2319   202 GH---TGAVRSV------AFspdgkLLASGSADGTVRLWDLAT-------------GKLLRTLTGhSGSV--RSVAFSPD 257

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462607647 698 fySHIVLAAGRNRTVEVFDLNAGcSAAVIAEAHSRPVHQICqnkgssFTtqqPQayNLFLTTAIGDGM-RLWDLRTLRCE 776
Cdd:COG2319   258 --GRLLASGSADGTVRLWDLATG-ELLRTLTGHSGGVNSVA------FS---PD--GKLLASGSDDGTvRLWDLATGKLL 323

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462607647 777 RHFEGHptRGYPCGIAFSPCGRFAACGAEDRHAYVYEMGSSTFSHRLAGHTDTVTGVAFNP 837
Cdd:COG2319   324 RTLTGH--TGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP 382
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 545-853 5.71e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 114.74  E-value: 5.71e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462607647 545 RVCCIQYSGDGQWLACGLANHLLLVFDASLTGTPAVFSGHDGAVNAVCWSQDRRWLLSAARDGTLRMWSAR-GAELALLL 623
Cdd:cd00200    11 GVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLEtGECVRTLT 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462607647 624 GkdmFSKPIQSAQFYYiDAFILLSSGPEFQLLRYHIDTCKdeikrykqksksKLICRLSTTGAVDMTSLSAVNDFyshiV 703
Cdd:cd00200    91 G---HTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGK------------CLTTLRGHTDWVNSVAFSPDGTF----V 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462607647 704 LAAGRNRTVEVFDLNAGCSAAVIaEAHSRPVHQICQNkgssfttqqPQAYNLFltTAIGDG-MRLWDLRTLRCERHFEGH 782
Cdd:cd00200   151 ASSSQDGTIKLWDLRTGKCVATL-TGHTGEVNSVAFS---------PDGEKLL--SSSSDGtIKLWDLSTGKCLGTLRGH 218

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462607647 783 ptRGYPCGIAFSPCGRFAACGAEDRHAYVYEMGSSTFSHRLAGHTDTVTGVAFNPSAPQMRTAlcqrmSWD 853
Cdd:cd00200   219 --ENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASG-----SAD 282
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 48-266 1.79e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 77.76  E-value: 1.79e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462607647  48 DGTeLCIWNTKDPShQLLILRGHHQPITAMAFGnkVNPLLICSASLD-YVIMWNLDECRE-KVLQGLVprgtvmgsllGK 125
Cdd:cd00200   114 DKT-IKVWDVETGK-CLTTLRGHTDWVNSVAFS--PDGTFVASSSQDgTIKLWDLRTGKCvATLTGHT----------GE 179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462607647 126 VLCLQLSPDDHVVAVCAGNK-IFMLDIeqrfsvtyierpdvnnrhkvppptflhtfsQTQAVRAELQGHLGPVTAVEFCP 204
Cdd:cd00200   180 VNSVAFSPDGEKLLSSSSDGtIKLWDL------------------------------STGKCLGTLRGHENGVNSVAFSP 229

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462607647 205 WRaGTLISASEDRSFKVWDHCTGSLIYsssVLSAY--PLLSLFIDAESRQLVTGCADGQLWIFS 266
Cdd:cd00200   230 DG-YLLASGSEDGTIRVWDLRTGECVQ---TLSGHtnSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
48-267 2.74e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 69.55  E-value: 2.74e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462607647  48 DGTeLCIWNTKDPShQLLILRGHHQPITAMAF---GNkvnplLICSASLD-YVIMWNLDECRE-KVLQGLVPRgtvmgsl 122
Cdd:COG2319   183 DGT-VRLWDLATGK-LLRTLTGHTGAVRSVAFspdGK-----LLASGSADgTVRLWDLATGKLlRTLTGHSGS------- 248

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462607647 123 lgkVLCLQLSPDDHVVAVC-AGNKIFMLDIEQRFSVTYIERPDvnnrHKV------PPPTFLHTFSQTQAVR-------- 187
Cdd:COG2319   249 ---VRSVAFSPDGRLLASGsADGTVRLWDLATGELLRTLTGHS----GGVnsvafsPDGKLLASGSDDGTVRlwdlatgk 321

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462607647 188 --AELQGHLGPVTAVEFCPWRaGTLISASEDRSFKVWDHCTGSLIYSSSVLSAyPLLSLFIDAESRQLVTGCADGQLWIF 265
Cdd:COG2319   322 llRTLTGHTGAVRSVAFSPDG-KTLASGSDDGTVRLWDLATGELLRTLTGHTG-AVTSVAFSPDGRTLASGSADGTVRLW 399


                  ..
gi 2462607647 266 SL 267
Cdd:COG2319   400 DL 401
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 579-613 3.22e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.00  E-value: 3.22e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2462607647  579 AVFSGHDGAVNAVCWSQDRRWLLSAARDGTLRMWS 613
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
579-613 3.46e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 50.04  E-value: 3.46e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2462607647 579 AVFSGHDGAVNAVCWSQDRRWLLSAARDGTLRMWS 613
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 183-223 6.84e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 6.84e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2462607647  183 TQAVRAELQGHLGPVTAVEFCPwRAGTLISASEDRSFKVWD 223
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
188-223 1.33e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 1.33e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2462607647 188 AELQGHLGPVTAVEFCPWRAgTLISASEDRSFKVWD 223
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGK-LLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
545-837 4.99e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 129.26  E-value: 4.99e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462607647 545 RVCCIQYSGDGQWLACGLANHLLLVFDASLTGTPAVFSGHDGAVNAVCWSQDRRWLLSAARDGTLRMWSAR-GAELALLL 623
Cdd:COG2319   122 AVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLT 201

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462607647 624 GKdmfSKPIQSAqfyyidAF-----ILLSSGPEFQLLRYHIDTckdeikrykqkskSKLICRLST-TGAVdmTSLSAVND 697
Cdd:COG2319   202 GH---TGAVRSV------AFspdgkLLASGSADGTVRLWDLAT-------------GKLLRTLTGhSGSV--RSVAFSPD 257

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462607647 698 fySHIVLAAGRNRTVEVFDLNAGcSAAVIAEAHSRPVHQICqnkgssFTtqqPQayNLFLTTAIGDGM-RLWDLRTLRCE 776
Cdd:COG2319   258 --GRLLASGSADGTVRLWDLATG-ELLRTLTGHSGGVNSVA------FS---PD--GKLLASGSDDGTvRLWDLATGKLL 323

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462607647 777 RHFEGHptRGYPCGIAFSPCGRFAACGAEDRHAYVYEMGSSTFSHRLAGHTDTVTGVAFNP 837
Cdd:COG2319   324 RTLTGH--TGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP 382
WD40 COG2319
WD40 repeat [General function prediction only];
545-837 1.24e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 119.25  E-value: 1.24e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462607647 545 RVCCIQYSGDGQWLACGLANHLLLVFDASLTGTPAVFSGHDGAVNAVCWSQDRRWLLSAARDGTLRMWSAR-GAELALLL 623
Cdd:COG2319    80 AVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAtGKLLRTLT 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462607647 624 GKdmfSKPIQSAqfyyidAF-----ILLSSGPEFQLLRYHIDTckdeikrykqkskSKLICRLS-TTGAVDMTSLSAvnD 697
Cdd:COG2319   160 GH---SGAVTSV------AFspdgkLLASGSDDGTVRLWDLAT-------------GKLLRTLTgHTGAVRSVAFSP--D 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462607647 698 fySHIVLAAGRNRTVEVFDLNAGcSAAVIAEAHSRPVHQIcqnkgsSFTTQqpqayNLFLTTAIGDGM-RLWDLRTLRCE 776
Cdd:COG2319   216 --GKLLASGSADGTVRLWDLATG-KLLRTLTGHSGSVRSV------AFSPD-----GRLLASGSADGTvRLWDLATGELL 281

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462607647 777 RHFEGHPtrGYPCGIAFSPCGRFAACGAEDRHAYVYEMGSSTFSHRLAGHTDTVTGVAFNP 837
Cdd:COG2319   282 RTLTGHS--GGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP 340
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 545-853 5.71e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 114.74  E-value: 5.71e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462607647 545 RVCCIQYSGDGQWLACGLANHLLLVFDASLTGTPAVFSGHDGAVNAVCWSQDRRWLLSAARDGTLRMWSAR-GAELALLL 623
Cdd:cd00200    11 GVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLEtGECVRTLT 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462607647 624 GkdmFSKPIQSAQFYYiDAFILLSSGPEFQLLRYHIDTCKdeikrykqksksKLICRLSTTGAVDMTSLSAVNDFyshiV 703
Cdd:cd00200    91 G---HTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGK------------CLTTLRGHTDWVNSVAFSPDGTF----V 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462607647 704 LAAGRNRTVEVFDLNAGCSAAVIaEAHSRPVHQICQNkgssfttqqPQAYNLFltTAIGDG-MRLWDLRTLRCERHFEGH 782
Cdd:cd00200   151 ASSSQDGTIKLWDLRTGKCVATL-TGHTGEVNSVAFS---------PDGEKLL--SSSSDGtIKLWDLSTGKCLGTLRGH 218

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462607647 783 ptRGYPCGIAFSPCGRFAACGAEDRHAYVYEMGSSTFSHRLAGHTDTVTGVAFNPSAPQMRTAlcqrmSWD 853
Cdd:cd00200   219 --ENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASG-----SAD 282
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 579-838 2.08e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 112.81  E-value: 2.08e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462607647 579 AVFSGHDGAVNAVCWSQDRRWLLSAARDGTLRMWS-ARGAELALLLGKdmfSKPIQSAQFYYIDAFILLSSGpefqllry 657
Cdd:cd00200     3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDlETGELLRTLKGH---TGPVRDVAASADGTYLASGSS-------- 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462607647 658 hiDTCkdeIKRYKqKSKSKLICRLST-TGAVdmTSLSAVNDfySHIVLAAGRNRTVEVFDLNAGCSAAVIaEAHSRPVHQ 736
Cdd:cd00200    72 --DKT---IRLWD-LETGECVRTLTGhTSYV--SSVAFSPD--GRILSSSSRDKTIKVWDVETGKCLTTL-RGHTDWVNS 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462607647 737 ICQNKGssfttqqpqayNLFLTTAIGDG-MRLWDLRTLRCERHFEGHptRGYPCGIAFSPCGRFAACGAEDRHAYVYEMG 815
Cdd:cd00200   141 VAFSPD-----------GTFVASSSQDGtIKLWDLRTGKCVATLTGH--TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS 207

                         250       260
                  ....*....|....*....|...
gi 2462607647 816 SSTFSHRLAGHTDTVTGVAFNPS 838
Cdd:cd00200   208 TGKCLGTLRGHENGVNSVAFSPD 230
WD40 COG2319
WD40 repeat [General function prediction only];
545-816 1.74e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.84  E-value: 1.74e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462607647 545 RVCCIQYSGDGQWLACGLANHLLLVFDASLTGTPAVFSGHDGAVNAVCWSQDRRWLLSAARDGTLRMWSARGAELALLLG 624
Cdd:COG2319   164 AVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLT 243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462607647 625 KDmfSKPIQSAqfyyidAF-----ILLSSGPEFQLLRYHIDTckdeikrykqkskSKLICRLST-TGAVdmTSLSAVNDf 698
Cdd:COG2319   244 GH--SGSVRSV------AFspdgrLLASGSADGTVRLWDLAT-------------GELLRTLTGhSGGV--NSVAFSPD- 299

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462607647 699 ySHIVLAAGRNRTVEVFDLNAGCSAAVIaEAHSRPVHQIcqnkgsSFTtqqpqAYNLFLTTAIGDGM-RLWDLRTLRCER 777
Cdd:COG2319   300 -GKLLASGSDDGTVRLWDLATGKLLRTL-TGHTGAVRSV------AFS-----PDGKTLASGSDDGTvRLWDLATGELLR 366

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 2462607647 778 HFEGHptRGYPCGIAFSPCGRFAACGAEDRHAYVYEMGS 816
Cdd:COG2319   367 TLTGH--TGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
551-837 1.63e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 100.76  E-value: 1.63e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462607647 551 YSGDGQWLACGLANHLLLVFDASLTGTPAVFSGHDGAVNAVCWSQDRRWLLSAARDGTLRMWSARGAELALLLGKdmFSK 630
Cdd:COG2319    44 ASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTG--HTG 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462607647 631 PIQSAQFyYIDAFILLSSGPEFQLLRYHIDTckdeikrykqkskSKLICRLST-TGAVDMTSLSAvnDfySHIVLAAGRN 709
Cdd:COG2319   122 AVRSVAF-SPDGKTLASGSADGTVRLWDLAT-------------GKLLRTLTGhSGAVTSVAFSP--D--GKLLASGSDD 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462607647 710 RTVEVFDLNAGCSAAVIaEAHSRPVHQIcqnkgsSFTtqqPQayNLFLTTAIGDGM-RLWDLRTLRCERHFEGHptRGYP 788
Cdd:COG2319   184 GTVRLWDLATGKLLRTL-TGHTGAVRSV------AFS---PD--GKLLASGSADGTvRLWDLATGKLLRTLTGH--SGSV 249

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 2462607647 789 CGIAFSPCGRFAACGAEDRHAYVYEMGSSTFSHRLAGHTDTVTGVAFNP 837
Cdd:COG2319   250 RSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSP 298
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 48-266 1.79e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 77.76  E-value: 1.79e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462607647  48 DGTeLCIWNTKDPShQLLILRGHHQPITAMAFGnkVNPLLICSASLD-YVIMWNLDECRE-KVLQGLVprgtvmgsllGK 125
Cdd:cd00200   114 DKT-IKVWDVETGK-CLTTLRGHTDWVNSVAFS--PDGTFVASSSQDgTIKLWDLRTGKCvATLTGHT----------GE 179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462607647 126 VLCLQLSPDDHVVAVCAGNK-IFMLDIeqrfsvtyierpdvnnrhkvppptflhtfsQTQAVRAELQGHLGPVTAVEFCP 204
Cdd:cd00200   180 VNSVAFSPDGEKLLSSSSDGtIKLWDL------------------------------STGKCLGTLRGHENGVNSVAFSP 229

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462607647 205 WRaGTLISASEDRSFKVWDHCTGSLIYsssVLSAY--PLLSLFIDAESRQLVTGCADGQLWIFS 266
Cdd:cd00200   230 DG-YLLASGSEDGTIRVWDLRTGECVQ---TLSGHtnSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
48-267 2.74e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 69.55  E-value: 2.74e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462607647  48 DGTeLCIWNTKDPShQLLILRGHHQPITAMAF---GNkvnplLICSASLD-YVIMWNLDECRE-KVLQGLVPRgtvmgsl 122
Cdd:COG2319   183 DGT-VRLWDLATGK-LLRTLTGHTGAVRSVAFspdGK-----LLASGSADgTVRLWDLATGKLlRTLTGHSGS------- 248

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462607647 123 lgkVLCLQLSPDDHVVAVC-AGNKIFMLDIEQRFSVTYIERPDvnnrHKV------PPPTFLHTFSQTQAVR-------- 187
Cdd:COG2319   249 ---VRSVAFSPDGRLLASGsADGTVRLWDLATGELLRTLTGHS----GGVnsvafsPDGKLLASGSDDGTVRlwdlatgk 321

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462607647 188 --AELQGHLGPVTAVEFCPWRaGTLISASEDRSFKVWDHCTGSLIYSSSVLSAyPLLSLFIDAESRQLVTGCADGQLWIF 265
Cdd:COG2319   322 llRTLTGHTGAVRSVAFSPDG-KTLASGSDDGTVRLWDLATGELLRTLTGHTG-AVTSVAFSPDGRTLASGSADGTVRLW 399


                  ..
gi 2462607647 266 SL 267
Cdd:COG2319   400 DL 401
WD40 COG2319
WD40 repeat [General function prediction only];
48-270 6.20e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 68.40  E-value: 6.20e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462607647  48 DGTeLCIWNTKDPShQLLILRGHHQPITAMAF---GNkvnpLLIcSASLDYVI-MWNLDECRE-KVLQGLVprgtvmgsl 122
Cdd:COG2319   141 DGT-VRLWDLATGK-LLRTLTGHSGAVTSVAFspdGK----LLA-SGSDDGTVrLWDLATGKLlRTLTGHT--------- 204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462607647 123 lGKVLCLQLSPDDHVVAVCAGNK-IFMLDIeqrfsvtyierpdvnnrhkvppptflhtfsQTQAVRAELQGHLGPVTAVE 201
Cdd:COG2319   205 -GAVRSVAFSPDGKLLASGSADGtVRLWDL------------------------------ATGKLLRTLTGHSGSVRSVA 253

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462607647 202 FCPWRAgTLISASEDRSFKVWDHCTGSLIYSSSVLSAyPLLSLFIDAESRQLVTGCADGQLWIFSLMDG 270
Cdd:COG2319   254 FSPDGR-LLASGSADGTVRLWDLATGELLRTLTGHSG-GVNSVAFSPDGKLLASGSDDGTVRLWDLATG 320
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 48-270 1.70e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 65.82  E-value: 1.70e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462607647  48 DGTeLCIWNTKDPShQLLILRGHHQPIT---AMAFGNKvnpllICSASLDY-VIMWNLdecrekvlQGLVPRGTVMGSLl 123
Cdd:cd00200    30 DGT-IKVWDLETGE-LLRTLKGHTGPVRdvaASADGTY-----LASGSSDKtIRLWDL--------ETGECVRTLTGHT- 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462607647 124 GKVLCLQLSPDDHVVAVCAGNK-IFMLDIE---QRFSVTYIERPdVNNRHKVPPPTFLHTFSQTQAVR----------AE 189
Cdd:cd00200    94 SYVSSVAFSPDGRILSSSSRDKtIKVWDVEtgkCLTTLRGHTDW-VNSVAFSPDGTFVASSSQDGTIKlwdlrtgkcvAT 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462607647 190 LQGHLGPVTAVEFCPwRAGTLISASEDRSFKVWDHCTGSLIYS-----SSVLSAypllsLFIDaeSRQLVTGCA-DGQLW 263
Cdd:cd00200   173 LTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTGKCLGTlrgheNGVNSV-----AFSP--DGYLLASGSeDGTIR 244


                  ....*..
gi 2462607647 264 IFSLMDG 270
Cdd:cd00200   245 VWDLRTG 251
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 545-613 2.08e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 62.74  E-value: 2.08e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462607647 545 RVCCIQYSGDGQWLACGLANHLLLVFDASLTGTPAVFSGHDGAVNAVCWSQDRRWLLSAARDGTLRMWS 613
Cdd:cd00200   221 GVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 579-613 3.22e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.00  E-value: 3.22e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2462607647  579 AVFSGHDGAVNAVCWSQDRRWLLSAARDGTLRMWS 613
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
579-613 3.46e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 50.04  E-value: 3.46e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2462607647 579 AVFSGHDGAVNAVCWSQDRRWLLSAARDGTLRMWS 613
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 187-271 8.53e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 54.65  E-value: 8.53e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462607647 187 RAELQGHLGPVTAVEFCPWRaGTLISASEDRSFKVWDHCTGSLIYSSSVLSAyPLLSLFIDAESRQLVTGCADGQLWIFS 266
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDG-KLLATGSGDGTIKVWDLETGELLRTLKGHTG-PVRDVAASADGTYLASGSSDKTIRLWD 79


                  ....*
gi 2462607647 267 LMDGH 271
Cdd:cd00200    80 LETGE 84
WD40 COG2319
WD40 repeat [General function prediction only];
182-270 8.78e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 52.22  E-value: 8.78e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462607647 182 QTQAVRAELQGHLGPVTAVEFCPwRAGTLISASEDRSFKVWDHCTGSLIYSSSVLSAyPLLSLFIDAESRQLVTGCADGQ 261
Cdd:COG2319   108 ATGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLATGKLLRTLTGHSG-AVTSVAFSPDGKLLASGSDDGT 185


                  ....*....
gi 2462607647 262 LWIFSLMDG 270
Cdd:COG2319   186 VRLWDLATG 194
WD40 COG2319
WD40 repeat [General function prediction only];
55-270 1.33e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 51.45  E-value: 1.33e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462607647  55 WNTKDPSHQLLILRGHHQPITAMAFGNKVNPLLicSASLDYVI-MWNLDecrekvlQGLVPRgtVMGSLLGKVLCLQLSP 133
Cdd:COG2319    62 LLDAAAGALLATLLGHTAAVLSVAFSPDGRLLA--SASADGTVrLWDLA-------TGLLLR--TLTGHTGAVRSVAFSP 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462607647 134 DDHVVAVCAGNK-IFMLDIEqrfsvtyierpdvnnrhkvppptflhtfsqTQAVRAELQGHLGPVTAVEFCPwrAG-TLI 211
Cdd:COG2319   131 DGKTLASGSADGtVRLWDLA------------------------------TGKLLRTLTGHSGAVTSVAFSP--DGkLLA 178

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462607647 212 SASEDRSFKVWDHCTGSLIYSSSVLSAyPLLSLFIDAESRQLVTGCADGQLWIFSLMDG 270
Cdd:COG2319   179 SGSDDGTVRLWDLATGKLLRTLTGHTG-AVRSVAFSPDGKLLASGSADGTVRLWDLATG 236
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 183-223 6.84e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 6.84e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2462607647  183 TQAVRAELQGHLGPVTAVEFCPwRAGTLISASEDRSFKVWD 223
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
188-223 1.33e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 1.33e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2462607647 188 AELQGHLGPVTAVEFCPWRAgTLISASEDRSFKVWD 223
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGK-LLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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