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Conserved domains on  [gi|2462620952|ref|XP_054217153|]
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oxidative stress-induced growth inhibitor 2 isoform X1 [Homo sapiens]

Protein Classification

NAD(P)/FAD-dependent oxidoreductase( domain architecture ID 1000380)

NAD(P)/FAD-dependent oxidoreductase catalyzes the transfer of electrons from one molecule, the electron donor or reductant, to another molecule, the electron acceptor or oxidant

CATH:  3.50.50.60
EC:  1.-.-.-
Gene Ontology:  GO:0016491
SCOP:  4000117

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
CzcO super family cl34398
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
117-317 2.31e-08

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


The actual alignment was detected with superfamily member COG2072:

Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 56.02  E-value: 2.31e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462620952 117 IPHVVLGKGP-PGGAWHNM--EGSMLTISfgSWM-ELPglkFKDWVSSKRRSLKGDrvmpeEIARYYKHYVKVMGLQKNF 192
Cdd:COG2072    30 IDFVVLEKADdVGGTWRDNryPGLRLDTP--SHLySLP---FFPNWSDDPDFPTGD-----EILAYLEAYADKFGLRRPI 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462620952 193 RENTYITSVSRlyrdqddddiqdrDISTKHlqieksnfikrnWEIrgyqRIADGSHvpfcLFAENVALATGTLDSPAHLE 272
Cdd:COG2072   100 RFGTEVTSARW-------------DEADGR------------WTV----TTDDGET----LTARFVVVATGPLSRPKIPD 146
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 2462620952 273 IEGEDfPF---VFHSmpefgAAINKG-KLRGKvdPVLIVGSGLTAADAV 317
Cdd:COG2072   147 IPGLE-DFageQLHS-----ADWRNPvDLAGK--RVLVVGTGASAVQIA 187
 
Name Accession Description Interval E-value
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
117-317 2.31e-08

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 56.02  E-value: 2.31e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462620952 117 IPHVVLGKGP-PGGAWHNM--EGSMLTISfgSWM-ELPglkFKDWVSSKRRSLKGDrvmpeEIARYYKHYVKVMGLQKNF 192
Cdd:COG2072    30 IDFVVLEKADdVGGTWRDNryPGLRLDTP--SHLySLP---FFPNWSDDPDFPTGD-----EILAYLEAYADKFGLRRPI 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462620952 193 RENTYITSVSRlyrdqddddiqdrDISTKHlqieksnfikrnWEIrgyqRIADGSHvpfcLFAENVALATGTLDSPAHLE 272
Cdd:COG2072   100 RFGTEVTSARW-------------DEADGR------------WTV----TTDDGET----LTARFVVVATGPLSRPKIPD 146
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 2462620952 273 IEGEDfPF---VFHSmpefgAAINKG-KLRGKvdPVLIVGSGLTAADAV 317
Cdd:COG2072   147 IPGLE-DFageQLHS-----ADWRNPvDLAGK--RVLVVGTGASAVQIA 187
PRK12770 PRK12770
putative glutamate synthase subunit beta; Provisional
258-333 7.88e-04

putative glutamate synthase subunit beta; Provisional


Pssm-ID: 237197 [Multi-domain]  Cd Length: 352  Bit Score: 41.51  E-value: 7.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462620952 258 VALATGTLDSpAHLEIEGEDFPFVFHSMpEFGAAINKGKL----RGKVDP-----VLIVGSGLTAADAVLCAYNSNI-PV 327
Cdd:PRK12770  122 VLIATGTWKS-RKLGIPGEDLPGVYSAL-EYLFRIRAAKLgylpWEKVPPvegkkVVVVGAGLTAVDAALEAVLLGAeKV 199

                  ....*.
gi 2462620952 328 IHVFRR 333
Cdd:PRK12770  200 YLAYRR 205
 
Name Accession Description Interval E-value
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
117-317 2.31e-08

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 56.02  E-value: 2.31e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462620952 117 IPHVVLGKGP-PGGAWHNM--EGSMLTISfgSWM-ELPglkFKDWVSSKRRSLKGDrvmpeEIARYYKHYVKVMGLQKNF 192
Cdd:COG2072    30 IDFVVLEKADdVGGTWRDNryPGLRLDTP--SHLySLP---FFPNWSDDPDFPTGD-----EILAYLEAYADKFGLRRPI 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462620952 193 RENTYITSVSRlyrdqddddiqdrDISTKHlqieksnfikrnWEIrgyqRIADGSHvpfcLFAENVALATGTLDSPAHLE 272
Cdd:COG2072   100 RFGTEVTSARW-------------DEADGR------------WTV----TTDDGET----LTARFVVVATGPLSRPKIPD 146
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 2462620952 273 IEGEDfPF---VFHSmpefgAAINKG-KLRGKvdPVLIVGSGLTAADAV 317
Cdd:COG2072   147 IPGLE-DFageQLHS-----ADWRNPvDLAGK--RVLVVGTGASAVQIA 187
YdhS COG4529
Uncharacterized NAD(P)/FAD-binding protein YdhS [General function prediction only];
242-318 2.58e-05

Uncharacterized NAD(P)/FAD-binding protein YdhS [General function prediction only];


Pssm-ID: 443597 [Multi-domain]  Cd Length: 466  Bit Score: 46.49  E-value: 2.58e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462620952 242 RIADGSHVPfclfAENVALATGTLdSPAHLEIEGEDFPFVFHSM--PEFGAAINKGklrgkvDPVLIVGSGLTAADAVL 318
Cdd:COG4529   142 TLADGETLR----ADAVVLATGHP-PPAPPPGLAAGSPRYIADPwpPGALARIPPD------ARVLIIGTGLTAIDVVL 209
GltD COG0493
NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport ...
258-320 7.70e-05

NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport and metabolism, General function prediction only]; NADPH-dependent glutamate synthase beta chain or related oxidoreductase is part of the Pathway/BioSystem: Glutamine biosynthesis


Pssm-ID: 440259 [Multi-domain]  Cd Length: 434  Bit Score: 45.13  E-value: 7.70e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462620952 258 VALATGTLDsPAHLEIEGEDFPFVFHSMpEFGAAINKGKLRGKVDP----VLIVGSGLTAADAVLCA 320
Cdd:COG0493   210 VFLATGAGK-PRDLGIPGEDLKGVHSAM-DFLTAVNLGEAPDTILAvgkrVVVIGGGNTAMDCARTA 274
PRK12770 PRK12770
putative glutamate synthase subunit beta; Provisional
258-333 7.88e-04

putative glutamate synthase subunit beta; Provisional


Pssm-ID: 237197 [Multi-domain]  Cd Length: 352  Bit Score: 41.51  E-value: 7.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462620952 258 VALATGTLDSpAHLEIEGEDFPFVFHSMpEFGAAINKGKL----RGKVDP-----VLIVGSGLTAADAVLCAYNSNI-PV 327
Cdd:PRK12770  122 VLIATGTWKS-RKLGIPGEDLPGVYSAL-EYLFRIRAAKLgylpWEKVPPvegkkVVVVGAGLTAVDAALEAVLLGAeKV 199

                  ....*.
gi 2462620952 328 IHVFRR 333
Cdd:PRK12770  200 YLAYRR 205
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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