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Conserved domains on  [gi|2462627224|ref|XP_054220156|]
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phospholipase A-2-activating protein isoform X2 [Homo sapiens]

Protein Classification

WD40 and PFU domain-containing protein( domain architecture ID 10078047)

WD40 and PFU domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-297 2.73e-61

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 203.34  E-value: 2.73e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627224  10 LSCSLRGHELDVRGlVCCAYPPGAFVSVSRDRTTRLWapDSPNRSFteMHCMSGHSNFVSCVCIIPSSDiyphgLIATGG 89
Cdd:cd00200     1 LRRTLKGHTGGVTC-VAFSPDGKLLATGSGDGTIKVW--DLETGEL--LRTLKGHTGPVRDVAASADGT-----YLASGS 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627224  90 NDHNICIFSLDSPMPLYILKGHKNTVCSLS-SGKFGTLLSGSWDTTAKVW--LNDKCMMTLQGHTAAVWAVKILPEQGLM 166
Cdd:cd00200    71 SDKTIRLWDLETGECVRTLTGHTSYVSSVAfSPDGRILSSSSRDKTIKVWdvETGKCLTTLRGHTDWVNSVAFSPDGTFV 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627224 167 LTGSADKTVKLW--KAGRCERTFSGHEDCVRGLAIL-SETEFLSCANDASIRRWQI-TGECLEVYYGHTNYIYSISVFPN 242
Cdd:cd00200   151 ASSSQDGTIKLWdlRTGKCVATLTGHTGEVNSVAFSpDGEKLLSSSSDGTIKLWDLsTGKCLGTLRGHENGVNSVAFSPD 230

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462627224 243 CRDFVTTAEDRSLRIW--KHGECAQTIRLPAQSIWCCCVLDNG-DIVVGASDGIIRVF 297
Cdd:cd00200   231 GYLLASGSEDGTIRVWdlRTGECVQTLSGHTNSVTSLAWSPDGkRLASGSADGTIRIW 288
PFU pfam09070
PFU (PLAA family ubiquitin binding); This domain is found N terminal to pfam08324 and binds to ...
 346-458 6.26e-60

PFU (PLAA family ubiquitin binding); This domain is found N terminal to pfam08324 and binds to ubiquitin.


:

Pssm-ID: 462670  Cd Length: 111  Bit Score: 193.51  E-value: 6.26e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627224 346 PGTREGQTRLIRDGE-KVEAYQWSVSEGRWIKIGDVVGSSGanqqTSGKVLYEGKEFDYVFSIDVNEGGPSYKLPYNTSD 424
Cdd:pfam09070   1 PGKKEGQVKMVREGNgVVEAYQWSAAEQQWEKIGDVVGSAG----SSQKKEYEGKEYDYVFDVDIEDGKPPLKLPYNVGD 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2462627224 425 DPWLTAYNFLQKNDLNPMFLDQVAKFIIDNTKGQ 458
Cdd:pfam09070  77 NPYEAAQKFLARNELPQSYLDQVVNFIIKNTGGV 110
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-297 2.73e-61

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 203.34  E-value: 2.73e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627224  10 LSCSLRGHELDVRGlVCCAYPPGAFVSVSRDRTTRLWapDSPNRSFteMHCMSGHSNFVSCVCIIPSSDiyphgLIATGG 89
Cdd:cd00200     1 LRRTLKGHTGGVTC-VAFSPDGKLLATGSGDGTIKVW--DLETGEL--LRTLKGHTGPVRDVAASADGT-----YLASGS 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627224  90 NDHNICIFSLDSPMPLYILKGHKNTVCSLS-SGKFGTLLSGSWDTTAKVW--LNDKCMMTLQGHTAAVWAVKILPEQGLM 166
Cdd:cd00200    71 SDKTIRLWDLETGECVRTLTGHTSYVSSVAfSPDGRILSSSSRDKTIKVWdvETGKCLTTLRGHTDWVNSVAFSPDGTFV 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627224 167 LTGSADKTVKLW--KAGRCERTFSGHEDCVRGLAIL-SETEFLSCANDASIRRWQI-TGECLEVYYGHTNYIYSISVFPN 242
Cdd:cd00200   151 ASSSQDGTIKLWdlRTGKCVATLTGHTGEVNSVAFSpDGEKLLSSSSDGTIKLWDLsTGKCLGTLRGHENGVNSVAFSPD 230

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462627224 243 CRDFVTTAEDRSLRIW--KHGECAQTIRLPAQSIWCCCVLDNG-DIVVGASDGIIRVF 297
Cdd:cd00200   231 GYLLASGSEDGTIRVWdlRTGECVQTLSGHTNSVTSLAWSPDGkRLASGSADGTIRIW 288
PFU pfam09070
PFU (PLAA family ubiquitin binding); This domain is found N terminal to pfam08324 and binds to ...
 346-458 6.26e-60

PFU (PLAA family ubiquitin binding); This domain is found N terminal to pfam08324 and binds to ubiquitin.


Pssm-ID: 462670  Cd Length: 111  Bit Score: 193.51  E-value: 6.26e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627224 346 PGTREGQTRLIRDGE-KVEAYQWSVSEGRWIKIGDVVGSSGanqqTSGKVLYEGKEFDYVFSIDVNEGGPSYKLPYNTSD 424
Cdd:pfam09070   1 PGKKEGQVKMVREGNgVVEAYQWSAAEQQWEKIGDVVGSAG----SSQKKEYEGKEYDYVFDVDIEDGKPPLKLPYNVGD 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2462627224 425 DPWLTAYNFLQKNDLNPMFLDQVAKFIIDNTKGQ 458
Cdd:pfam09070  77 NPYEAAQKFLARNELPQSYLDQVVNFIIKNTGGV 110
WD40 COG2319
WD40 repeat [General function prediction only];
13-296 3.73e-47

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 169.32  E-value: 3.73e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627224  13 SLRGHELDVRGLVCcAYPPGAFVSVSRDRTTRLWAPDSPNRSFTemhcMSGHSNFVSCVCIIPSSDIyphglIATGGNDH 92
Cdd:COG2319    73 TLLGHTAAVLSVAF-SPDGRLLASASADGTVRLWDLATGLLLRT----LTGHTGAVRSVAFSPDGKT-----LASGSADG 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627224  93 NICIFSLDSPMPLYILKGHKNTVCSLS---SGKfgTLLSGSWDTTAKVW--LNDKCMMTLQGHTAAVWAVKILPEQGLML 167
Cdd:COG2319   143 TVRLWDLATGKLLRTLTGHSGAVTSVAfspDGK--LLASGSDDGTVRLWdlATGKLLRTLTGHTGAVRSVAFSPDGKLLA 220

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627224 168 TGSADKTVKLW--KAGRCERTFSGHEDCVRGLAILSETEFL-SCANDASIRRWQI-TGECLEVYYGHTNYIYSISVFPNC 243
Cdd:COG2319   221 SGSADGTVRLWdlATGKLLRTLTGHSGSVRSVAFSPDGRLLaSGSADGTVRLWDLaTGELLRTLTGHSGGVNSVAFSPDG 300

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462627224 244 RDFVTTAEDRSLRIW--KHGECAQTIRLPAQSIWCCCVLDNGD-IVVGASDGIIRV 296
Cdd:COG2319   301 KLLASGSDDGTVRLWdlATGKLLRTLTGHTGAVRSVAFSPDGKtLASGSDDGTVRL 356
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 142-179 1.96e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.31  E-value: 1.96e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2462627224  142 KCMMTLQGHTAAVWAVKILPEQGLMLTGSADKTVKLWK 179
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
142-178 4.02e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.57  E-value: 4.02e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2462627224 142 KCMMTLQGHTAAVWAVKILPEQGLMLTGSADKTVKLW 178
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 7-207 1.07e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 48.16  E-value: 1.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627224   7 RYRLSCSLRGHELDVRGLVCCAYPPGAFVSVSRDRTTRLWAPDSPnrsfTEMHCMSGHSNFvsCVCIIPSSDIYPhglIA 86
Cdd:PLN00181  564 RSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQG----VSIGTIKTKANI--CCVQFPSESGRS---LA 634

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627224  87 TGGNDHNICIFSLDSP-MPLYILKGHKNTVCSLSSGKFGTLLSGSWDTTAKVW--------LNDKCMMTLQGHTAAVWAV 157
Cdd:PLN00181  635 FGSADHKVYYYDLRNPkLPLCTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWdlsmsisgINETPLHSFMGHTNVKNFV 714

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2462627224 158 KILPEQGLMLTGSADKTVKLWKAGRCERTFS---GHEDCVRGLAILSETEFLS 207
Cdd:PLN00181  715 GLSVSDGYIATGSETNEVFVYHKAFPMPVLSykfKTIDPVSGLEVDDASQFIS 767
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-297 2.73e-61

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 203.34  E-value: 2.73e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627224  10 LSCSLRGHELDVRGlVCCAYPPGAFVSVSRDRTTRLWapDSPNRSFteMHCMSGHSNFVSCVCIIPSSDiyphgLIATGG 89
Cdd:cd00200     1 LRRTLKGHTGGVTC-VAFSPDGKLLATGSGDGTIKVW--DLETGEL--LRTLKGHTGPVRDVAASADGT-----YLASGS 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627224  90 NDHNICIFSLDSPMPLYILKGHKNTVCSLS-SGKFGTLLSGSWDTTAKVW--LNDKCMMTLQGHTAAVWAVKILPEQGLM 166
Cdd:cd00200    71 SDKTIRLWDLETGECVRTLTGHTSYVSSVAfSPDGRILSSSSRDKTIKVWdvETGKCLTTLRGHTDWVNSVAFSPDGTFV 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627224 167 LTGSADKTVKLW--KAGRCERTFSGHEDCVRGLAIL-SETEFLSCANDASIRRWQI-TGECLEVYYGHTNYIYSISVFPN 242
Cdd:cd00200   151 ASSSQDGTIKLWdlRTGKCVATLTGHTGEVNSVAFSpDGEKLLSSSSDGTIKLWDLsTGKCLGTLRGHENGVNSVAFSPD 230

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462627224 243 CRDFVTTAEDRSLRIW--KHGECAQTIRLPAQSIWCCCVLDNG-DIVVGASDGIIRVF 297
Cdd:cd00200   231 GYLLASGSEDGTIRVWdlRTGECVQTLSGHTNSVTSLAWSPDGkRLASGSADGTIRIW 288
PFU pfam09070
PFU (PLAA family ubiquitin binding); This domain is found N terminal to pfam08324 and binds to ...
 346-458 6.26e-60

PFU (PLAA family ubiquitin binding); This domain is found N terminal to pfam08324 and binds to ubiquitin.


Pssm-ID: 462670  Cd Length: 111  Bit Score: 193.51  E-value: 6.26e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627224 346 PGTREGQTRLIRDGE-KVEAYQWSVSEGRWIKIGDVVGSSGanqqTSGKVLYEGKEFDYVFSIDVNEGGPSYKLPYNTSD 424
Cdd:pfam09070   1 PGKKEGQVKMVREGNgVVEAYQWSAAEQQWEKIGDVVGSAG----SSQKKEYEGKEYDYVFDVDIEDGKPPLKLPYNVGD 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2462627224 425 DPWLTAYNFLQKNDLNPMFLDQVAKFIIDNTKGQ 458
Cdd:pfam09070  77 NPYEAAQKFLARNELPQSYLDQVVNFIIKNTGGV 110
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 9-259 2.85e-52

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 179.45  E-value: 2.85e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627224   9 RLSCSLRGHELDVRGLVCCAYPPgAFVSVSRDRTTRLWAPDSPNRSFTemhcMSGHSNFVSCVCIIPSSDIyphglIATG 88
Cdd:cd00200    42 ELLRTLKGHTGPVRDVAASADGT-YLASGSSDKTIRLWDLETGECVRT----LTGHTSYVSSVAFSPDGRI-----LSSS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627224  89 GNDHNICIFSLDSPMPLYILKGHKNTVCSLSSGKFGTLL-SGSWDTTAKVW--LNDKCMMTLQGHTAAVWAVKILPEQGL 165
Cdd:cd00200   112 SRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVaSSSQDGTIKLWdlRTGKCVATLTGHTGEVNSVAFSPDGEK 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627224 166 MLTGSADKTVKLW--KAGRCERTFSGHEDCVRGLAILSETEFL-SCANDASIRRWQI-TGECLEVYYGHTNYIYSISVFP 241
Cdd:cd00200   192 LLSSSSDGTIKLWdlSTGKCLGTLRGHENGVNSVAFSPDGYLLaSGSEDGTIRVWDLrTGECVQTLSGHTNSVTSLAWSP 271

                         250
                  ....*....|....*...
gi 2462627224 242 NCRDFVTTAEDRSLRIWK 259
Cdd:cd00200   272 DGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
13-296 3.73e-47

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 169.32  E-value: 3.73e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627224  13 SLRGHELDVRGLVCcAYPPGAFVSVSRDRTTRLWAPDSPNRSFTemhcMSGHSNFVSCVCIIPSSDIyphglIATGGNDH 92
Cdd:COG2319    73 TLLGHTAAVLSVAF-SPDGRLLASASADGTVRLWDLATGLLLRT----LTGHTGAVRSVAFSPDGKT-----LASGSADG 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627224  93 NICIFSLDSPMPLYILKGHKNTVCSLS---SGKfgTLLSGSWDTTAKVW--LNDKCMMTLQGHTAAVWAVKILPEQGLML 167
Cdd:COG2319   143 TVRLWDLATGKLLRTLTGHSGAVTSVAfspDGK--LLASGSDDGTVRLWdlATGKLLRTLTGHTGAVRSVAFSPDGKLLA 220

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627224 168 TGSADKTVKLW--KAGRCERTFSGHEDCVRGLAILSETEFL-SCANDASIRRWQI-TGECLEVYYGHTNYIYSISVFPNC 243
Cdd:COG2319   221 SGSADGTVRLWdlATGKLLRTLTGHSGSVRSVAFSPDGRLLaSGSADGTVRLWDLaTGELLRTLTGHSGGVNSVAFSPDG 300

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462627224 244 RDFVTTAEDRSLRIW--KHGECAQTIRLPAQSIWCCCVLDNGD-IVVGASDGIIRV 296
Cdd:COG2319   301 KLLASGSDDGTVRLWdlATGKLLRTLTGHTGAVRSVAFSPDGKtLASGSDDGTVRL 356
WD40 COG2319
WD40 repeat [General function prediction only];
13-258 5.75e-45

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 163.16  E-value: 5.75e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627224  13 SLRGHELDVRGLvccAY-PPGAF-VSVSRDRTTRLWAPDSPNRSFTemhcMSGHSNFVSCVCIIPSSDiyphgLIATGGN 90
Cdd:COG2319   157 TLTGHSGAVTSV---AFsPDGKLlASGSDDGTVRLWDLATGKLLRT----LTGHTGAVRSVAFSPDGK-----LLASGSA 224

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627224  91 DHNICIFSLDSPMPLYILKGHKNTVCSLS---SGKfgTLLSGSWDTTAKVW--LNDKCMMTLQGHTAAVWAVKILPEQGL 165
Cdd:COG2319   225 DGTVRLWDLATGKLLRTLTGHSGSVRSVAfspDGR--LLASGSADGTVRLWdlATGELLRTLTGHSGGVNSVAFSPDGKL 302

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627224 166 MLTGSADKTVKLWKA--GRCERTFSGHEDCVRGLAILSETEFL-SCANDASIRRWQI-TGECLEVYYGHTNYIYSISVFP 241
Cdd:COG2319   303 LASGSDDGTVRLWDLatGKLLRTLTGHTGAVRSVAFSPDGKTLaSGSDDGTVRLWDLaTGELLRTLTGHTGAVTSVAFSP 382

                         250
                  ....*....|....*..
gi 2462627224 242 NCRDFVTTAEDRSLRIW 258
Cdd:COG2319   383 DGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
9-180 1.85e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 114.24  E-value: 1.85e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627224   9 RLSCSLRGHELDVRGLvccAYPP-GAF-VSVSRDRTTRLWAPDSPNRSFTemhcMSGHSNFVSCVCIIPSSDiyphgLIA 86
Cdd:COG2319   237 KLLRTLTGHSGSVRSV---AFSPdGRLlASGSADGTVRLWDLATGELLRT----LTGHSGGVNSVAFSPDGK-----LLA 304

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627224  87 TGGNDHNICIFSLDSPMPLYILKGHKNTVCSLS---SGKfgTLLSGSWDTTAKVW--LNDKCMMTLQGHTAAVWAVKILP 161
Cdd:COG2319   305 SGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAfspDGK--TLASGSDDGTVRLWdlATGELLRTLTGHTGAVTSVAFSP 382

                         170
                  ....*....|....*....
gi 2462627224 162 EQGLMLTGSADKTVKLWKA 180
Cdd:COG2319   383 DGRTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
124-297 1.24e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 106.15  E-value: 1.24e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627224 124 GTLLSGSWDTTAKVWLND--KCMMTLQGHTAAVWAVKILPEQGLMLTGSADKTVKLWKA--GRCERTFSGHEDCVRGLAI 199
Cdd:COG2319    49 ARLAAGAGDLTLLLLDAAagALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLatGLLLRTLTGHTGAVRSVAF 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627224 200 LSETEFL-SCANDASIRRWQI-TGECLEVYYGHTNYIYSISVFPNCRDFVTTAEDRSLRIW--KHGECAQTIRLPAQSIW 275
Cdd:COG2319   129 SPDGKTLaSGSADGTVRLWDLaTGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWdlATGKLLRTLTGHTGAVR 208

                         170       180
                  ....*....|....*....|...
gi 2462627224 276 CCCVLDNGD-IVVGASDGIIRVF 297
Cdd:COG2319   209 SVAFSPDGKlLASGSADGTVRLW 231
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 142-179 1.96e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.31  E-value: 1.96e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2462627224  142 KCMMTLQGHTAAVWAVKILPEQGLMLTGSADKTVKLWK 179
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
142-178 4.02e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.57  E-value: 4.02e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2462627224 142 KCMMTLQGHTAAVWAVKILPEQGLMLTGSADKTVKLW 178
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 220-259 6.24e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 6.24e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2462627224  220 TGECLEVYYGHTNYIYSISVFPNCRDFVTTAEDRSLRIWK 259
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 7-207 1.07e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 48.16  E-value: 1.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627224   7 RYRLSCSLRGHELDVRGLVCCAYPPGAFVSVSRDRTTRLWAPDSPnrsfTEMHCMSGHSNFvsCVCIIPSSDIYPhglIA 86
Cdd:PLN00181  564 RSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQG----VSIGTIKTKANI--CCVQFPSESGRS---LA 634

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627224  87 TGGNDHNICIFSLDSP-MPLYILKGHKNTVCSLSSGKFGTLLSGSWDTTAKVW--------LNDKCMMTLQGHTAAVWAV 157
Cdd:PLN00181  635 FGSADHKVYYYDLRNPkLPLCTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWdlsmsisgINETPLHSFMGHTNVKNFV 714

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2462627224 158 KILPEQGLMLTGSADKTVKLWKAGRCERTFS---GHEDCVRGLAILSETEFLS 207
Cdd:PLN00181  715 GLSVSDGYIATGSETNEVFVYHKAFPMPVLSykfKTIDPVSGLEVDDASQFIS 767
WD40 COG2319
WD40 repeat [General function prediction only];
13-101 2.21e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.83  E-value: 2.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627224  13 SLRGHELDVRGLvccAYPP--GAFVSVSRDRTTRLWAPDSPnrsfTEMHCMSGHSNFVSCVCIIPSSDiyphgLIATGGN 90
Cdd:COG2319   325 TLTGHTGAVRSV---AFSPdgKTLASGSDDGTVRLWDLATG----ELLRTLTGHTGAVTSVAFSPDGR-----TLASGSA 392

                          90
                  ....*....|.
gi 2462627224  91 DHNICIFSLDS 101
Cdd:COG2319   393 DGTVRLWDLAT 403
WD40 pfam00400
WD domain, G-beta repeat;
221-258 1.07e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 1.07e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2462627224 221 GECLEVYYGHTNYIYSISVFPNCRDFVTTAEDRSLRIW 258
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
104-138 3.63e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 3.63e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2462627224 104 PLYILKGHKNTVCSLSSGKFGTLL-SGSWDTTAKVW 138
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLaSGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 54-98 1.24e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 1.24e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 2462627224   54 SFTEMHCMSGHSNFVSCVCIIPSSDiyphgLIATGGNDHNICIFS 98
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGK-----YLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 104-138 4.23e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.98  E-value: 4.23e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2462627224  104 PLYILKGHKNTVCSLS-SGKFGTLLSGSWDTTAKVW 138
Cdd:smart00320   4 LLKTLKGHTGPVTSVAfSPDGKYLASGSDDGTIKLW 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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