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Conserved domains on  [gi|2462519927|ref|XP_054222202|]
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renalase isoform X6 [Homo sapiens]

Protein Classification

NAD(P)/FAD-dependent oxidoreductase( domain architecture ID 13825468)

NAD(P)/FAD-dependent oxidoreductase which catalyzes the transfer of electrons from one molecule, the electron donor or reductant, to another molecule, the electron acceptor or oxidant; similar to renalase

Gene Ontology:  GO:0016491
PubMed:  28624475

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HemY super family cl34197
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 13-210 3.01e-10

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


The actual alignment was detected with superfamily member COG1232:

Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 59.85  E-value: 3.01e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519927  13 GSLCAALLRRQTSGP-----LYL-----AVWDK-ADD-SGAEVYFRHRVTQINLRDDKWEVSKQTGSPEQFDLIVLTMPV 80
Cdd:COG1232   183 GSLIKGALALRKGAKagevfGYLrgglgTLVEAlAEAlEAGEIRLGTRVTAIEREGGGWRVTTSDGETIEADAVVSATPA 262

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519927  81 PEILQLQGDITTLISEcqrqQLEAVSYSSRYALGLFYEAGTKIDVPWAGQYITSNPCIRFvsidnkKRNIESSEIGPSLv 160
Cdd:COG1232   263 PALARLLAPLPPEVAA----ALAGIPYASVAVVALGFDRPDLPPPDGFGWLVPRDEGVPI------LAVTFSSNKWPHR- 331

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462519927 161 ihttVPFGVTYL-------------EHSIEDVQELVFQQLENILPGLPQPIATKCQKWRHSQV 210
Cdd:COG1232   332 ----APDGKVLLrlevggagdpelwQLSDEELVALALADLRKLLGIDAEPVDTRVVRWPKAYP 390
UbiH super family cl43226
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme ...
 1-23 2.34e-03

2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases is part of the Pathway/BioSystem: Ubiquinone biosynthesis


The actual alignment was detected with superfamily member COG0654:

Pssm-ID: 440419 [Multi-domain]  Cd Length: 326  Bit Score: 38.77  E-value: 2.34e-03
                          10        20
                  ....*....|....*....|...
gi 2462519927   1 MAQVLIVGAGMTGSLCAALLRRQ 23
Cdd:COG0654     3 RTDVLIVGGGPAGLALALALARA 25
 
Name Accession Description Interval E-value
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 13-210 3.01e-10

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 59.85  E-value: 3.01e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519927  13 GSLCAALLRRQTSGP-----LYL-----AVWDK-ADD-SGAEVYFRHRVTQINLRDDKWEVSKQTGSPEQFDLIVLTMPV 80
Cdd:COG1232   183 GSLIKGALALRKGAKagevfGYLrgglgTLVEAlAEAlEAGEIRLGTRVTAIEREGGGWRVTTSDGETIEADAVVSATPA 262

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519927  81 PEILQLQGDITTLISEcqrqQLEAVSYSSRYALGLFYEAGTKIDVPWAGQYITSNPCIRFvsidnkKRNIESSEIGPSLv 160
Cdd:COG1232   263 PALARLLAPLPPEVAA----ALAGIPYASVAVVALGFDRPDLPPPDGFGWLVPRDEGVPI------LAVTFSSNKWPHR- 331

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462519927 161 ihttVPFGVTYL-------------EHSIEDVQELVFQQLENILPGLPQPIATKCQKWRHSQV 210
Cdd:COG1232   332 ----APDGKVLLrlevggagdpelwQLSDEELVALALADLRKLLGIDAEPVDTRVVRWPKAYP 390
Amino_oxidase pfam01593
Flavin containing amine oxidoreductase; This family consists of various amine oxidases, ...
 40-214 1.40e-05

Flavin containing amine oxidoreductase; This family consists of various amine oxidases, including maze polyamine oxidase (PAO)and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.


Pssm-ID: 396255 [Multi-domain]  Cd Length: 446  Bit Score: 45.56  E-value: 1.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519927  40 GAEVYFRHRVTQINLRDDKWEVSKQTGSPEQFDLIVLTMPVPeILQLQGDITTLISEcQRQQLEAVSYSSRYALGLFYE- 118
Cdd:pfam01593 218 GGDVRLNTRVRSIDREGDGVTVTLTDGEVIEADAVIVTVPLG-VLKRILFTPPLPPE-KARAIRNLGYGPVNKVHLEFDr 295

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519927 119 -AGTKIDVPWAGQYITSNPCIRFVSIDNKKRNIEsseiGPSLVIHTTVPFGVTYLE---HSIEDVQELVFQQLENILP-G 193
Cdd:pfam01593 296 kFWPDLGLLGLLSELLTGLGTAFSWLTFPNRAPP----GKGLLLLVYVGPGDRARElegLSDEELLQAVLRDLRKLFGeE 371

                         170       180
                  ....*....|....*....|.
gi 2462519927 194 LPQPIATKCQKWRHSQVTNAA 214
Cdd:pfam01593 372 APEPLRVLVSDWHTDPWPRGS 392
UbiH COG0654
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme ...
 1-23 2.34e-03

2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440419 [Multi-domain]  Cd Length: 326  Bit Score: 38.77  E-value: 2.34e-03
                          10        20
                  ....*....|....*....|...
gi 2462519927   1 MAQVLIVGAGMTGSLCAALLRRQ 23
Cdd:COG0654     3 RTDVLIVGGGPAGLALALALARA 25
 
Name Accession Description Interval E-value
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 13-210 3.01e-10

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 59.85  E-value: 3.01e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519927  13 GSLCAALLRRQTSGP-----LYL-----AVWDK-ADD-SGAEVYFRHRVTQINLRDDKWEVSKQTGSPEQFDLIVLTMPV 80
Cdd:COG1232   183 GSLIKGALALRKGAKagevfGYLrgglgTLVEAlAEAlEAGEIRLGTRVTAIEREGGGWRVTTSDGETIEADAVVSATPA 262

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519927  81 PEILQLQGDITTLISEcqrqQLEAVSYSSRYALGLFYEAGTKIDVPWAGQYITSNPCIRFvsidnkKRNIESSEIGPSLv 160
Cdd:COG1232   263 PALARLLAPLPPEVAA----ALAGIPYASVAVVALGFDRPDLPPPDGFGWLVPRDEGVPI------LAVTFSSNKWPHR- 331

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462519927 161 ihttVPFGVTYL-------------EHSIEDVQELVFQQLENILPGLPQPIATKCQKWRHSQV 210
Cdd:COG1232   332 ----APDGKVLLrlevggagdpelwQLSDEELVALALADLRKLLGIDAEPVDTRVVRWPKAYP 390
Amino_oxidase pfam01593
Flavin containing amine oxidoreductase; This family consists of various amine oxidases, ...
 40-214 1.40e-05

Flavin containing amine oxidoreductase; This family consists of various amine oxidases, including maze polyamine oxidase (PAO)and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.


Pssm-ID: 396255 [Multi-domain]  Cd Length: 446  Bit Score: 45.56  E-value: 1.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519927  40 GAEVYFRHRVTQINLRDDKWEVSKQTGSPEQFDLIVLTMPVPeILQLQGDITTLISEcQRQQLEAVSYSSRYALGLFYE- 118
Cdd:pfam01593 218 GGDVRLNTRVRSIDREGDGVTVTLTDGEVIEADAVIVTVPLG-VLKRILFTPPLPPE-KARAIRNLGYGPVNKVHLEFDr 295

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519927 119 -AGTKIDVPWAGQYITSNPCIRFVSIDNKKRNIEsseiGPSLVIHTTVPFGVTYLE---HSIEDVQELVFQQLENILP-G 193
Cdd:pfam01593 296 kFWPDLGLLGLLSELLTGLGTAFSWLTFPNRAPP----GKGLLLLVYVGPGDRARElegLSDEELLQAVLRDLRKLFGeE 371

                         170       180
                  ....*....|....*....|.
gi 2462519927 194 LPQPIATKCQKWRHSQVTNAA 214
Cdd:pfam01593 372 APEPLRVLVSDWHTDPWPRGS 392
NAD_binding_8 pfam13450
NAD(P)-binding Rossmann-like domain;
6-40 1.33e-04

NAD(P)-binding Rossmann-like domain;


Pssm-ID: 433218 [Multi-domain]  Cd Length: 67  Bit Score: 39.05  E-value: 1.33e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2462519927   6 IVGAGMTGSLCAALLRRQtsgPLYLAVWDKADDSG 40
Cdd:pfam13450   1 IVGAGLAGLVAAALLAKR---GFRVLVLEKRDRLG 32
YobN COG1231
Monoamine oxidase [Amino acid transport and metabolism];
3-226 2.12e-03

Monoamine oxidase [Amino acid transport and metabolism];


Pssm-ID: 440844 [Multi-domain]  Cd Length: 440  Bit Score: 39.13  E-value: 2.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519927   3 QVLIVGaGMtGSLCAALlrrqtsgplylavwdkADDSGAEVYFRHRVTQINLRDDKWEVSKQTGSPEQFDLIVLTMPVPe 82
Cdd:COG1231   194 QFRIVG-GM-DQLPRAL----------------AAELGDRIRLGAPVTRIRQDGDGVTVTTDDGGTVRADAVIVTVPPS- 254

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519927  83 ILQLQgDITTLISECQRQQLEAVSYSSRYALGLFYEAgtkidvPW-------AGQYITSNPcIRFVSiDNKKRNIESsei 155
Cdd:COG1231   255 VLRRI-EFDPPLPAAKRAAIQRLPYGAAIKVFLQFDR------PFweedglyGGISLTDLP-IRQTW-YPSNGPDGG--- 322

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462519927 156 GPSLVIHTTVPFGVTYLEHSIEDVQELVFQQLENILPGL-PQPIATKCQKWRHSQVTNAAANC--PGQMTLHHK 226
Cdd:COG1231   323 AGVLLGYVGGDDARALAALSPEERVAAALEQLARIFGVYaAEPVDYVSTDWGRDPWSRGAYAAapPGQLTAAGP 396
UbiH COG0654
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme ...
 1-23 2.34e-03

2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440419 [Multi-domain]  Cd Length: 326  Bit Score: 38.77  E-value: 2.34e-03
                          10        20
                  ....*....|....*....|...
gi 2462519927   1 MAQVLIVGAGMTGSLCAALLRRQ 23
Cdd:COG0654     3 RTDVLIVGGGPAGLALALALARA 25
FadH2 COG0446
NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase ...
 4-83 4.02e-03

NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism];


Pssm-ID: 440215 [Multi-domain]  Cd Length: 322  Bit Score: 37.87  E-value: 4.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519927   4 VLIVGAGMTGSLCAALLRRQ-------TSGPLYLAVWDKA---------DDSGAEVYFRHRVTQINlRDDKWEVSKQTGS 67
Cdd:COG0446   127 AVVIGGGPIGLELAEALRKRglkvtlvERAPRLLGVLDPEmaalleeelREHGVELRLGETVVAID-GDDKVAVTLTDGE 205

                          90
                  ....*....|....*..
gi 2462519927  68 PEQFDLIVLTMPV-PEI 83
Cdd:COG0446   206 EIPADLVVVAPGVrPNT 222
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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