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Conserved domains on  [gi|2462522506|ref|XP_054223440|]
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deformed epidermal autoregulatory factor 1 homolog isoform X4 [Homo sapiens]

Protein Classification

SET and MYND domain-containing protein( domain architecture ID 10245136)

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) and zinc finger MYND domain-containing protein similar to human N-lysine methyltransferase SMYD2 and histone-lysine N-methyltransferase SMYD3

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SAND super family cl02536
SAND domain; The DNA binding activity of two proteins has been mapped to the SAND domain. The ...
 1-30 1.09e-10

SAND domain; The DNA binding activity of two proteins has been mapped to the SAND domain. The conserved KDWK motif is necessary for DNA binding, and it appears to be important for dimerization. This region is also found in the putative transcription factor RegA from the multicellular green alga Volvox cateri. This region of RegA is known as the VARL domain.


The actual alignment was detected with superfamily member pfam01342:

Pssm-ID: 470606  Cd Length: 76  Bit Score: 56.82  E-value: 1.09e-10
                          10        20        30
                  ....*....|....*....|....*....|
gi 2462522506   1 MAGRASSKDWKRSIRYAGRPLQCLIQDGIL 30
Cdd:pfam01342  47 EGGKASSKDWKRSIRCGGKPLRELIEKGLL 76
zf-MYND pfam01753
MYND finger;
262-289 1.39e-04

MYND finger;


:

Pssm-ID: 460312  Cd Length: 39  Bit Score: 38.55  E-value: 1.39e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 2462522506 262 CVNCGREAMSE--CTGCHKVNYCSTFCQRK 289
Cdd:pfam01753   1 CAVCGKEALKLlrCSRCKSVYYCSKECQKA 30
 
Name Accession Description Interval E-value
SAND pfam01342
SAND domain; The DNA binding activity of two proteins has been mapped to the SAND domain. The ...
 1-30 1.09e-10

SAND domain; The DNA binding activity of two proteins has been mapped to the SAND domain. The conserved KDWK motif is necessary for DNA binding, and it appears to be important for dimerization. This region is also found in the putative transcription factor RegA from the multicellular green alga Volvox cateri. This region of RegA is known as the VARL domain.


Pssm-ID: 460167  Cd Length: 76  Bit Score: 56.82  E-value: 1.09e-10
                          10        20        30
                  ....*....|....*....|....*....|
gi 2462522506   1 MAGRASSKDWKRSIRYAGRPLQCLIQDGIL 30
Cdd:pfam01342  47 EGGKASSKDWKRSIRCGGKPLRELIEKGLL 76
SAND smart00258
SAND domain;
1-31 7.33e-10

SAND domain;


Pssm-ID: 128554  Cd Length: 73  Bit Score: 54.27  E-value: 7.33e-10
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2462522506    1 MAGRASSKDWKRSIRYAGRPLQCLIQDGILN 31
Cdd:smart00258  43 EGGKGKSKDWKRSIRCGGSSLRTLMENGTLD 73
zf-MYND pfam01753
MYND finger;
262-289 1.39e-04

MYND finger;


Pssm-ID: 460312  Cd Length: 39  Bit Score: 38.55  E-value: 1.39e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 2462522506 262 CVNCGREAMSE--CTGCHKVNYCSTFCQRK 289
Cdd:pfam01753   1 CAVCGKEALKLlrCSRCKSVYYCSKECQKA 30
 
Name Accession Description Interval E-value
SAND pfam01342
SAND domain; The DNA binding activity of two proteins has been mapped to the SAND domain. The ...
 1-30 1.09e-10

SAND domain; The DNA binding activity of two proteins has been mapped to the SAND domain. The conserved KDWK motif is necessary for DNA binding, and it appears to be important for dimerization. This region is also found in the putative transcription factor RegA from the multicellular green alga Volvox cateri. This region of RegA is known as the VARL domain.


Pssm-ID: 460167  Cd Length: 76  Bit Score: 56.82  E-value: 1.09e-10
                          10        20        30
                  ....*....|....*....|....*....|
gi 2462522506   1 MAGRASSKDWKRSIRYAGRPLQCLIQDGIL 30
Cdd:pfam01342  47 EGGKASSKDWKRSIRCGGKPLRELIEKGLL 76
SAND smart00258
SAND domain;
1-31 7.33e-10

SAND domain;


Pssm-ID: 128554  Cd Length: 73  Bit Score: 54.27  E-value: 7.33e-10
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2462522506    1 MAGRASSKDWKRSIRYAGRPLQCLIQDGILN 31
Cdd:smart00258  43 EGGKGKSKDWKRSIRCGGSSLRTLMENGTLD 73
zf-MYND pfam01753
MYND finger;
262-289 1.39e-04

MYND finger;


Pssm-ID: 460312  Cd Length: 39  Bit Score: 38.55  E-value: 1.39e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 2462522506 262 CVNCGREAMSE--CTGCHKVNYCSTFCQRK 289
Cdd:pfam01753   1 CAVCGKEALKLlrCSRCKSVYYCSKECQKA 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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