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Conserved domains on  [gi|2462527432|ref|XP_054225852|]
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zinc finger protein 143 isoform X5 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
251-424 1.31e-14

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 76.66  E-value: 1.31e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527432 251 AHHLKVHERSHTGdRPYQCEHAGCGKAFATGYGLKSHVRT--HTGE--KPYRCSEDNCTKSFKTSGDLQKHIRTHTGERP 326
Cdd:COG5048   273 SSPNESDSSSEKG-FSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSISP 351

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527432 327 FKCPFEGCGRSFTTSNIRKVHVRTH-----TGERPYYCTEPGCGRAFASATNYKNHVRIHTGEKPYVCTVPGCDKRFTEY 401
Cdd:COG5048   352 AKEKLLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRH 431

                         170       180
                  ....*....|....*....|...
gi 2462527432 402 SSLYKHHVVHTHSKPYNCNHCGK 424
Cdd:COG5048   432 YNLIPHKKIHTNHAPLLCSILKS 454
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
251-424 1.31e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 76.66  E-value: 1.31e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527432 251 AHHLKVHERSHTGdRPYQCEHAGCGKAFATGYGLKSHVRT--HTGE--KPYRCSEDNCTKSFKTSGDLQKHIRTHTGERP 326
Cdd:COG5048   273 SSPNESDSSSEKG-FSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSISP 351

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527432 327 FKCPFEGCGRSFTTSNIRKVHVRTH-----TGERPYYCTEPGCGRAFASATNYKNHVRIHTGEKPYVCTVPGCDKRFTEY 401
Cdd:COG5048   352 AKEKLLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRH 431

                         170       180
                  ....*....|....*....|...
gi 2462527432 402 SSLYKHHVVHTHSKPYNCNHCGK 424
Cdd:COG5048   432 YNLIPHKKIHTNHAPLLCSILKS 454
zf-H2C2_2 pfam13465
Zinc-finger double domain;
313-340 9.39e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.36  E-value: 9.39e-06
                          10        20
                  ....*....|....*....|....*...
gi 2462527432 313 DLQKHIRTHTGERPFKCPFegCGRSFTT 340
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
251-424 1.31e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 76.66  E-value: 1.31e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527432 251 AHHLKVHERSHTGdRPYQCEHAGCGKAFATGYGLKSHVRT--HTGE--KPYRCSEDNCTKSFKTSGDLQKHIRTHTGERP 326
Cdd:COG5048   273 SSPNESDSSSEKG-FSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSISP 351

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527432 327 FKCPFEGCGRSFTTSNIRKVHVRTH-----TGERPYYCTEPGCGRAFASATNYKNHVRIHTGEKPYVCTVPGCDKRFTEY 401
Cdd:COG5048   352 AKEKLLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRH 431

                         170       180
                  ....*....|....*....|...
gi 2462527432 402 SSLYKHHVVHTHSKPYNCNHCGK 424
Cdd:COG5048   432 YNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
355-430 5.30e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.94  E-value: 5.30e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462527432 355 RPYYCtePGCGRAFASATNYKNHVRIHTGEKPYVCTVPGCDKRFTEYSSLYKHHVVHTHSKPYNCNHCGKTYKQIS 430
Cdd:COG5048    32 RPDSC--PNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKA 105
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 383-440 6.61e-08

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 55.11  E-value: 6.61e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462527432 383 GEKPYVCTVPGCDKRFTEYSSLyKHHVVHTH--------------------SKPYNCNHCGKTYKQISTLAMHKRTAH 440
Cdd:COG5189   346 DGKPYKCPVEGCNKKYKNQNGL-KYHMLHGHqnqklhenpspekmnifsakDKPYRCEVCDKRYKNLNGLKYHRKHSH 422
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 249-413 1.73e-07

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 53.95  E-value: 1.73e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527432 249 TTAHHLKVHERSHTGDRPYQCEHAGCGK---AFATGYGLKSHVRTHTGEKPYRCSEDNCTKSFKTSGDLQKHIrthtGER 325
Cdd:COG5189   273 SQGSAELFEESSLGFDYEFIHKSVGNKEirgGISTGEMIDVRKLPCTNSSSNGKLAHGGERNIDTPSRMLKVK----DGK 348

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527432 326 PFKCPFEGCGRSFTTSNIRKVHvRTHTGERPYYCTEPgcgrafasatNYKNHVRIHTGEKPYVCTVpgCDKRFTEYSSLy 405
Cdd:COG5189   349 PYKCPVEGCNKKYKNQNGLKYH-MLHGHQNQKLHENP----------SPEKMNIFSAKDKPYRCEV--CDKRYKNLNGL- 414


                  ....*...
gi 2462527432 406 KHHVVHTH 413
Cdd:COG5189   415 KYHRKHSH 422
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
264-322 2.76e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.08  E-value: 2.76e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462527432 264 DRPYQCEhaGCGKAFATGYGLKSHVRTHTGEKPYRCSEDNCTKSFKTSGDLQKHIRTHT 322
Cdd:COG5048    31 PRPDSCP--NCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHH 87
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
359-442 9.05e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 9.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527432 359 CTEPGCGRAFASATNYKNHVR--IHTGE--KPYVCTVPGCDKRFTEYSSLYKHHVVHTHSKPYNC--NHCGKTYKQIST- 431
Cdd:COG5048   290 IKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNn 369

                          90
                  ....*....|....*
gi 2462527432 432 ----LAMHKRTAHND 442
Cdd:COG5048   370 eppqSLQQYKDLKND 384
zf-H2C2_2 pfam13465
Zinc-finger double domain;
313-340 9.39e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.36  E-value: 9.39e-06
                          10        20
                  ....*....|....*....|....*...
gi 2462527432 313 DLQKHIRTHTGERPFKCPFegCGRSFTT 340
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
284-310 1.40e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.97  E-value: 1.40e-05
                          10        20
                  ....*....|....*....|....*..
gi 2462527432 284 LKSHVRTHTGEKPYRCSEdnCTKSFKT 310
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPE--CGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
232-408 1.70e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.77  E-value: 1.70e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527432 232 SGEKAFRCEYDGCGKLYTTAHHLKVHERSHTGDRPYQCEHAGCGKafatgyglkshvrTHTGEKPYrcsednctksfKTS 311
Cdd:COG5048   317 ESLKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSS-------------KFSPLLNN-----------EPP 372

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527432 312 GDLQKHIRTHTgERPFKCPFEGCGRSFTTSNIRKVHVRTHTGERPYYCTEPGCGRAFASATNYKNHVRIHTGEKPYVCtv 391
Cdd:COG5048   373 QSLQQYKDLKN-DKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC-- 449

                         170
                  ....*....|....*..
gi 2462527432 392 pgCDKRFTEYSSLYKHH 408
Cdd:COG5048   450 --SILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
295-445 2.45e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.38  E-value: 2.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527432 295 KPYRCseDNCTKSFKTSGDLQKHIRTHTGERPFKCPFEGCGRSFTTSNIRKVHVRTHTgERPYYCTEPGCGRAFASATNY 374
Cdd:COG5048    32 RPDSC--PNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHH-NNPSDLNSKSLPLSNSKASSS 108

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462527432 375 KNHvrIHTGEKPYVCTVPGCDKRFTEYSSLYKHHVVHTHS---KPYNCNHCGKTYKQISTLAMHKRTAHNDTEP 445
Cdd:COG5048   109 SLS--SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLrnnPLPGNNSSSVNTPQSNSLHPPLPANSLSKDP 180
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 269-356 3.30e-05

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 43.18  E-value: 3.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527432 269 CEHAGCGKAFATGYGLKSHVRTHTGE------KPYRCSEDNCTKSFKTSGDLQKHIRTH-TGERPFKCpfEGCGRSFTT- 340
Cdd:pfam15909   2 CSSPGCCLSFPSVRDLAQHLRTHCPPtqslegKLFRCSALSCTETFPSMQELVAHSKLHyKPNRYFKC--ENCLLRFRTh 79

                          90
                  ....*....|....*..
gi 2462527432 341 -SNIRKVHVRTHTGERP 356
Cdd:pfam15909  80 rSLFKHLHVCAEHAQSP 96
zf-H2C2_2 pfam13465
Zinc-finger double domain;
253-280 1.02e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 1.02e-04
                          10        20
                  ....*....|....*....|....*...
gi 2462527432 253 HLKVHERSHTGDRPYQCEHagCGKAFAT 280
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 233-292 1.37e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.71  E-value: 1.37e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462527432 233 GEKAFRCEYDGCGKLYTTAHHLKVH---------------ERSHTG----DRPYQCEHagCGKAFATGYGLKSHvRTHT 292
Cdd:COG5189   346 DGKPYKCPVEGCNKKYKNQNGLKYHmlhghqnqklhenpsPEKMNIfsakDKPYRCEV--CDKRYKNLNGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
373-399 1.43e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.43e-04
                          10        20
                  ....*....|....*....|....*..
gi 2462527432 373 NYKNHVRIHTGEKPYVCTVpgCDKRFT 399
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFK 25
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 299-415 1.13e-03

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 38.55  E-value: 1.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527432 299 CSEDNCTKSFKTSGDLQKHIRTHtgerpfkCPfegcgrsfTTSNIRKvhvrthtgeRPYYCTEPGCGRAFASATNYKNHV 378
Cdd:pfam15909   2 CSSPGCCLSFPSVRDLAQHLRTH-------CP--------PTQSLEG---------KLFRCSALSCTETFPSMQELVAHS 57

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2462527432 379 RIHTGEKPYVcTVPGCDKRFTEYSSLYKH-HVVHTHSK 415
Cdd:pfam15909  58 KLHYKPNRYF-KCENCLLRFRTHRSLFKHlHVCAEHAQ 94
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 297-321 1.31e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.51  E-value: 1.31e-03
                          10        20
                  ....*....|....*....|....*
gi 2462527432 297 YRCSEdnCTKSFKTSGDLQKHIRTH 321
Cdd:pfam00096   1 YKCPD--CGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
345-370 1.75e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.75e-03
                          10        20
                  ....*....|....*....|....*.
gi 2462527432 345 KVHVRTHTGERPYYCTEpgCGRAFAS 370
Cdd:pfam13465   3 KRHMRTHTGEKPYKCPE--CGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
221-458 2.04e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.22  E-value: 2.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527432 221 HATRVTAKS-QQSGEKAFRCEY-DGCGKLYTTAHHLKVHERSHTGDRPYQCEHAGCGKAFATGYGLKSHVRTHTGEKPYR 298
Cdd:COG5048    14 SVLSSTPKStLKSLSNAPRPDScPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527432 299 CSEDNCTKSFKTSGDL----------------------QKHIRTHTGERP---FKCPFEGCGRSFT----TSNIRKVHVR 349
Cdd:COG5048    94 NSKSLPLSNSKASSSSlsssssnsndnnllsshslppsSRDPQLPDLLSIsnlRNNPLPGNNSSSVntpqSNSLHPPLPA 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527432 350 THTGERPYYCTEPGCGRAFASA--TNYKNHVRIHTGEKPYVCTVPGCDKRFTEYSSLYKHHVVHTHS---------KPYN 418
Cdd:COG5048   174 NSLSKDPSSNLSLLISSNVSTSipSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLlsqspsslsSSDS 253

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 2462527432 419 CNHCGKTYKQISTLAMHKRTAHNDTEpiEEEQEAFFEPPP 458
Cdd:COG5048   254 SSSASESPRSSLPTASSQSSSPNESD--SSSEKGFSLPIK 291
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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