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Conserved domains on  [gi|2462531617|ref|XP_054227869|]
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host cell factor 2 isoform X3 [Homo sapiens]

Protein Classification

Kelch domain-containing protein( domain architecture ID 1002449)

Kelch domain-containing protein is a protein that contains one or more kelch domains which play a role in a variety of cellular processes, including cell signaling, transcription regulation, and protein degradation.

Gene Ontology:  GO:0016567|GO:0080028
PubMed:  31442578|24959344

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
14-332 4.66e-20

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 90.60  E-value: 4.66e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462531617  14 SFTGPVPRARHGHRAVAIRELMIIFGGGNEG-IADELHVYNTATNQWflpaVRGDIPPGCAAHGFVC--DGTRILVFGGM 90
Cdd:COG3055     4 SSLPDLPTPRSEAAAALLDGKVYVAGGLSGGsASNSFEVYDPATNTW----SELAPLPGPPRHHAAAvaQDGKLYVFGGF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462531617  91 VEYGRYSN-----ELYELQASRWlwkkvkphpPPSGLPPCPRLGHSFSLYGNKCYLFGGlanesedsnNNVPRYLNDFYE 165
Cdd:COG3055    80 TGANPSSTplndvYVYDPATNTW---------TKLAPMPTPRGGATALLLDGKIYVVGG---------WDDGGNVAWVEV 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462531617 166 LELQHGSgvvgWSipvTKGVVPSPRESHTAVIyckkdSGSPKMYVFGGMCGARLDDLWqldletmswskpETKGTVPLPR 245
Cdd:COG3055   142 YDPATGT----WT---QLAPLPTPRDHLAAAV-----LPDGKILVIGGRNGSGFSNTW------------TTLAPLPTAR 197

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462531617 246 SLHTASVIGNKMYIFGGwvphkgentETSPHDCEWRctssfsyLNLDTTEWTTLvsdsqedkkNSRPRPRAGHCAVAIGT 325
Cdd:COG3055   198 AGHAAAVLGGKILVFGG---------ESGFSDEVEA-------YDPATNTWTAL---------GELPTPRHGHAAVLTDG 252


                  ....*..
gi 2462531617 326 RLYFWSG 332
Cdd:COG3055   253 KVYVIGG 259
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 312-355 8.16e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


:

Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 37.16  E-value: 8.16e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2462531617 312 PRPRAGHCAVAIGTRLYFWSGRDGYkkalNSQVcCKDLWYLDTE 355
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGYTGG----EGQP-SDDVYVLSLP 39
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
14-332 4.66e-20

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 90.60  E-value: 4.66e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462531617  14 SFTGPVPRARHGHRAVAIRELMIIFGGGNEG-IADELHVYNTATNQWflpaVRGDIPPGCAAHGFVC--DGTRILVFGGM 90
Cdd:COG3055     4 SSLPDLPTPRSEAAAALLDGKVYVAGGLSGGsASNSFEVYDPATNTW----SELAPLPGPPRHHAAAvaQDGKLYVFGGF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462531617  91 VEYGRYSN-----ELYELQASRWlwkkvkphpPPSGLPPCPRLGHSFSLYGNKCYLFGGlanesedsnNNVPRYLNDFYE 165
Cdd:COG3055    80 TGANPSSTplndvYVYDPATNTW---------TKLAPMPTPRGGATALLLDGKIYVVGG---------WDDGGNVAWVEV 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462531617 166 LELQHGSgvvgWSipvTKGVVPSPRESHTAVIyckkdSGSPKMYVFGGMCGARLDDLWqldletmswskpETKGTVPLPR 245
Cdd:COG3055   142 YDPATGT----WT---QLAPLPTPRDHLAAAV-----LPDGKILVIGGRNGSGFSNTW------------TTLAPLPTAR 197

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462531617 246 SLHTASVIGNKMYIFGGwvphkgentETSPHDCEWRctssfsyLNLDTTEWTTLvsdsqedkkNSRPRPRAGHCAVAIGT 325
Cdd:COG3055   198 AGHAAAVLGGKILVFGG---------ESGFSDEVEA-------YDPATNTWTAL---------GELPTPRHGHAAVLTDG 252


                  ....*..
gi 2462531617 326 RLYFWSG 332
Cdd:COG3055   253 KVYVIGG 259
PLN02193 PLN02193
nitrile-specifier protein
 2-262 3.64e-12

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 68.83  E-value: 3.64e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462531617   2 AAPSLL-NWRRV-SSFTGPVPRARHGHRAVAIRelMIIFGGG---NEGIADELHVYNTATNQWFLPAVRGDIPP-GCAAH 75
Cdd:PLN02193  145 STPKLLgKWIKVeQKGEGPGLRCSHGIAQVGNK--IYSFGGEftpNQPIDKHLYVFDLETRTWSISPATGDVPHlSCLGV 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462531617  76 GFVCDGTRILVFGGMvEYGRYSNELYELQASRWLWKKVkphpPPSGLPPCPRLGHSFSLYGNKCYLFGGLANESE----D 151
Cdd:PLN02193  223 RMVSIGSTLYVFGGR-DASRQYNGFYSFDTTTNEWKLL----TPVEEGPTPRSFHSMAADEENVYVFGGVSATARlktlD 297

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462531617 152 SNNNVPRylndfyelELQHGSgvvgwsipvtkgvvpSPRESHTAVIYCKKDSGSPKMYVFGGMCGARLDDLWQLDLETMS 231
Cdd:PLN02193  298 SYNIVDK--------KWFHCS---------------TPGDSFSIRGGAGLEVVQGKVWVVYGFNGCEVDDVHYYDPVQDK 354

                         250       260       270
                  ....*....|....*....|....*....|.
gi 2462531617 232 WSKPETKGTVPLPRSLHTASVIGNKMYIFGG 262
Cdd:PLN02193  355 WTQVETFGVRPSERSVFASAAVGKHIVIFGG 385
Kelch_3 pfam13415
Galactose oxidase, central domain;
207-253 2.10e-06

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 44.97  E-value: 2.10e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2462531617 207 KMYVFGGMC---GARLDDLWQLDLETMSWSKPetkGTVPLPRSLHTASVI 253
Cdd:pfam13415   3 KLYIFGGLGfdgQTRLNDLYVYDLDTNTWTQI---GDLPPPRSGHSATYI 49
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 312-355 8.16e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 37.16  E-value: 8.16e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2462531617 312 PRPRAGHCAVAIGTRLYFWSGRDGYkkalNSQVcCKDLWYLDTE 355
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGYTGG----EGQP-SDDVYVLSLP 39
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
14-332 4.66e-20

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 90.60  E-value: 4.66e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462531617  14 SFTGPVPRARHGHRAVAIRELMIIFGGGNEG-IADELHVYNTATNQWflpaVRGDIPPGCAAHGFVC--DGTRILVFGGM 90
Cdd:COG3055     4 SSLPDLPTPRSEAAAALLDGKVYVAGGLSGGsASNSFEVYDPATNTW----SELAPLPGPPRHHAAAvaQDGKLYVFGGF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462531617  91 VEYGRYSN-----ELYELQASRWlwkkvkphpPPSGLPPCPRLGHSFSLYGNKCYLFGGlanesedsnNNVPRYLNDFYE 165
Cdd:COG3055    80 TGANPSSTplndvYVYDPATNTW---------TKLAPMPTPRGGATALLLDGKIYVVGG---------WDDGGNVAWVEV 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462531617 166 LELQHGSgvvgWSipvTKGVVPSPRESHTAVIyckkdSGSPKMYVFGGMCGARLDDLWqldletmswskpETKGTVPLPR 245
Cdd:COG3055   142 YDPATGT----WT---QLAPLPTPRDHLAAAV-----LPDGKILVIGGRNGSGFSNTW------------TTLAPLPTAR 197

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462531617 246 SLHTASVIGNKMYIFGGwvphkgentETSPHDCEWRctssfsyLNLDTTEWTTLvsdsqedkkNSRPRPRAGHCAVAIGT 325
Cdd:COG3055   198 AGHAAAVLGGKILVFGG---------ESGFSDEVEA-------YDPATNTWTAL---------GELPTPRHGHAAVLTDG 252


                  ....*..
gi 2462531617 326 RLYFWSG 332
Cdd:COG3055   253 KVYVIGG 259
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
9-264 2.06e-18

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 85.59  E-value: 2.06e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462531617   9 WRRVSSFTGPvprARHGHRAVAIRELMIIFGG-----GNEGIADELHVYNTATNQWFlpaVRGDIPPGCAAHGFVCDGTR 83
Cdd:COG3055    50 WSELAPLPGP---PRHHAAAVAQDGKLYVFGGftganPSSTPLNDVYVYDPATNTWT---KLAPMPTPRGGATALLLDGK 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462531617  84 ILVFGGMVEYGRYSN-ELYELQASRWlwkkvkphpPPSGLPPCPRLGHS-FSLYGNKCYLFGGlANESEDSNNnvpryln 161
Cdd:COG3055   124 IYVVGGWDDGGNVAWvEVYDPATGTW---------TQLAPLPTPRDHLAaAVLPDGKILVIGG-RNGSGFSNT------- 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462531617 162 dfyelelqhgsgvvgWSipvTKGVVPSPRESHTAVIYckkdsgSPKMYVFGGMCGArLDDLWQLDLETMSWSkpeTKGTV 241
Cdd:COG3055   187 ---------------WT---TLAPLPTARAGHAAAVL------GGKILVFGGESGF-SDEVEAYDPATNTWT---ALGEL 238

                         250       260
                  ....*....|....*....|...
gi 2462531617 242 PLPRSLHTASVIGNKMYIFGGWV 264
Cdd:COG3055   239 PTPRHGHAAVLTDGKVYVIGGET 261
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
134-335 6.61e-17

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 81.36  E-value: 6.61e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462531617 134 LYGNKCYLFGGLANESedsnnnvprYLNDFYELELQHGSgvvgWSipvTKGVVPSPRESHTAVIYCKKdsgspKMYVFGG 213
Cdd:COG3055    20 LLDGKVYVAGGLSGGS---------ASNSFEVYDPATNT----WS---ELAPLPGPPRHHAAAVAQDG-----KLYVFGG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462531617 214 MCGAR-----LDDLWQLDLETMSWSKpetKGTVPLPRSLHTASVIGNKMYIFGGWVPHKGentetsphdcewrcTSSFSY 288
Cdd:COG3055    79 FTGANpsstpLNDVYVYDPATNTWTK---LAPMPTPRGGATALLLDGKIYVVGGWDDGGN--------------VAWVEV 141

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 2462531617 289 LNLDTTEWTTLVSDsqedkknsrPRPRAGHCA-VAIGTRLYFWSGRDG 335
Cdd:COG3055   142 YDPATGTWTQLAPL---------PTPRDHLAAaVLPDGKILVIGGRNG 180
PLN02193 PLN02193
nitrile-specifier protein
 2-262 3.64e-12

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 68.83  E-value: 3.64e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462531617   2 AAPSLL-NWRRV-SSFTGPVPRARHGHRAVAIRelMIIFGGG---NEGIADELHVYNTATNQWFLPAVRGDIPP-GCAAH 75
Cdd:PLN02193  145 STPKLLgKWIKVeQKGEGPGLRCSHGIAQVGNK--IYSFGGEftpNQPIDKHLYVFDLETRTWSISPATGDVPHlSCLGV 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462531617  76 GFVCDGTRILVFGGMvEYGRYSNELYELQASRWLWKKVkphpPPSGLPPCPRLGHSFSLYGNKCYLFGGLANESE----D 151
Cdd:PLN02193  223 RMVSIGSTLYVFGGR-DASRQYNGFYSFDTTTNEWKLL----TPVEEGPTPRSFHSMAADEENVYVFGGVSATARlktlD 297

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462531617 152 SNNNVPRylndfyelELQHGSgvvgwsipvtkgvvpSPRESHTAVIYCKKDSGSPKMYVFGGMCGARLDDLWQLDLETMS 231
Cdd:PLN02193  298 SYNIVDK--------KWFHCS---------------TPGDSFSIRGGAGLEVVQGKVWVVYGFNGCEVDDVHYYDPVQDK 354

                         250       260       270
                  ....*....|....*....|....*....|.
gi 2462531617 232 WSKPETKGTVPLPRSLHTASVIGNKMYIFGG 262
Cdd:PLN02193  355 WTQVETFGVRPSERSVFASAAVGKHIVIFGG 385
PLN02153 PLN02153
epithiospecifier protein
 16-264 1.98e-10

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 62.70  E-value: 1.98e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462531617  16 TGPVPRARHGHRAVAirELMIIFGGG---NEGIADELHVYNTATNQWFLPAVRGDIPP-GCAAHGFVCDGTRILVFGGMV 91
Cdd:PLN02153   18 KGPGPRCSHGIAVVG--DKLYSFGGElkpNEHIDKDLYVFDFNTHTWSIAPANGDVPRiSCLGVRMVAVGTKLYIFGGRD 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462531617  92 EYGRYSN-ELYELQASRWLWkkvkPHPPPSGLPPCPRLGHSFSLYGNKCYLFGGLaneSEDSNNNVPRYLNDFYELELQH 170
Cdd:PLN02153   96 EKREFSDfYSYDTVKNEWTF----LTKLDEEGGPEARTFHSMASDENHVYVFGGV---SKGGLMKTPERFRTIEAYNIAD 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462531617 171 GsgvvGWSipvtkgVVPSPRESHTA--------------VIYCKKDSGSPkmyvfGGMCGARLDDLWQLDLETMSWSKPE 236
Cdd:PLN02153  169 G----KWV------QLPDPGENFEKrggagfavvqgkiwVVYGFATSILP-----GGKSDYESNAVQFFDPASGKWTEVE 233

                         250       260
                  ....*....|....*....|....*...
gi 2462531617 237 TKGTVPLPRSLHTASVIGNKMYIFGGWV 264
Cdd:PLN02153  234 TTGAKPSARSVFAHAVVGKYIIIFGGEV 261
PLN02193 PLN02193
nitrile-specifier protein
 77-262 3.74e-07

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 52.65  E-value: 3.74e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462531617  77 FVCDGTRILVFggmveYGRYSNELYELQASRWL---------WKKVKPHPPPSGLppcpRLGHSFSLYGNKCYLFGGlan 147
Cdd:PLN02193  116 FVLQGGKIVGF-----HGRSTDVLHSLGAYISLpstpkllgkWIKVEQKGEGPGL----RCSHGIAQVGNKIYSFGG--- 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462531617 148 eSEDSNNNVPRYLNDFyELELQhgsgvvGWSIPVTKGVVPspresHTAVIYCKKDSGSPKMYVFGGMCGAR-LDDLWQLD 226
Cdd:PLN02193  184 -EFTPNQPIDKHLYVF-DLETR------TWSISPATGDVP-----HLSCLGVRMVSIGSTLYVFGGRDASRqYNGFYSFD 250

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 2462531617 227 LETMSWS--KPETKGtvPLPRSLHTASVIGNKMYIFGG 262
Cdd:PLN02193  251 TTTNEWKllTPVEEG--PTPRSFHSMAADEENVYVFGG 286
Kelch_3 pfam13415
Galactose oxidase, central domain;
207-253 2.10e-06

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 44.97  E-value: 2.10e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2462531617 207 KMYVFGGMC---GARLDDLWQLDLETMSWSKPetkGTVPLPRSLHTASVI 253
Cdd:pfam13415   3 KLYIFGGLGfdgQTRLNDLYVYDLDTNTWTQI---GDLPPPRSGHSATYI 49
PLN02193 PLN02193
nitrile-specifier protein
 232-375 2.93e-06

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 49.95  E-value: 2.93e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462531617 232 WSKPETKGTVPLPRSLHTASVIGNKMYIFGgwvphkGENTETSPHDcewrctSSFSYLNLDTTEWTtlVSDSQEDKKNSR 311
Cdd:PLN02193  153 WIKVEQKGEGPGLRCSHGIAQVGNKIYSFG------GEFTPNQPID------KHLYVFDLETRTWS--ISPATGDVPHLS 218

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462531617 312 PrprAGHCAVAIGTRLYFWSGRDGYKK--ALNSQVCCKDLWYLDT--EKPPAPSQVQLIKATTNSFHV 375
Cdd:PLN02193  219 C---LGVRMVSIGSTLYVFGGRDASRQynGFYSFDTTTNEWKLLTpvEEGPTPRSFHSMAADEENVYV 283
PRK14131 PRK14131
N-acetylneuraminate epimerase;
9-89 3.12e-06

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 49.63  E-value: 3.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462531617   9 WRRVSSFTGPvprARHGHRAVAIRELMIIFGG----GNEG---IADELHVYNTATNQWFLPAVRGdiPPGCAAH-GFVCD 80
Cdd:PRK14131   64 WTKIAAFPGG---PREQAVAAFIDGKLYVFGGigktNSEGspqVFDDVYKYDPKTNSWQKLDTRS--PVGLAGHvAVSLH 138


                  ....*....
gi 2462531617  81 GTRILVFGG 89
Cdd:PRK14131  139 NGKAYITGG 147
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
8-104 5.54e-06

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 48.23  E-value: 5.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462531617   8 NWRRVSSFtgPVPRARHGHRAVAIRelmIIFGGGNEGIADELHVYNTATNQWFlpaVRGDIPPGCAAHGFVCDGTRILVF 87
Cdd:COG3055   186 TWTTLAPL--PTARAGHAAAVLGGK---ILVFGGESGFSDEVEAYDPATNTWT---ALGELPTPRHGHAAVLTDGKVYVI 257

                          90
                  ....*....|....*..
gi 2462531617  88 GGMVEYGRYSNELYELQ 104
Cdd:COG3055   258 GGETKPGVRTPLVTSAE 274
Kelch_3 pfam13415
Galactose oxidase, central domain;
254-323 3.34e-04

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 38.43  E-value: 3.34e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462531617 254 GNKMYIFGGWVPHKGEntetsphdcewrCTSSFSYLNLDTTEWTTLvsdsqedkkNSRPRPRAGHCAVAI 323
Cdd:pfam13415   1 GDKLYIFGGLGFDGQT------------RLNDLYVYDLDTNTWTQI---------GDLPPPRSGHSATYI 49
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 312-355 8.16e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 37.16  E-value: 8.16e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2462531617 312 PRPRAGHCAVAIGTRLYFWSGRDGYkkalNSQVcCKDLWYLDTE 355
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGYTGG----EGQP-SDDVYVLSLP 39
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
231-337 8.29e-04

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 41.68  E-value: 8.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462531617 231 SWSkpeTKGTVPLPRSLHTASVIGNKMYIFGGWvphkGENTETSPHDCewrctssfsyLNLDTTEWTTLVSDSQEdkkns 310
Cdd:COG3055     2 TWS---SLPDLPTPRSEAAAALLDGKVYVAGGL----SGGSASNSFEV----------YDPATNTWSELAPLPGP----- 59

                          90       100
                  ....*....|....*....|....*..
gi 2462531617 311 rprPRAGHCAVAIGTRLYFWSGRDGYK 337
Cdd:COG3055    60 ---PRHHAAAVAQDGKLYVFGGFTGAN 83
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 244-301 9.40e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 37.21  E-value: 9.40e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462531617 244 PRSLHTASVIGNKMYIFGGWvphkgentetsphdCEWRCTSSFSYLNLDTTEWTTLVS 301
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGF--------------DGNQSLNSVEVYDPETNTWSKLPS 44
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 187-229 1.11e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 36.77  E-value: 1.11e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2462531617 187 PSPRESHTAVIYckkdsgSPKMYVFGGMCGAR---LDDLWQLDLET 229
Cdd:pfam13854   1 PVPRYGHCAVTV------GDYIYLYGGYTGGEgqpSDDVYVLSLPT 40
Kelch_4 pfam13418
Galactose oxidase, central domain;
189-234 1.33e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 36.82  E-value: 1.33e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2462531617 189 PRESHTAViYCKKDSGspkmYVFGGMC--GARLDDLWQLDLETMSWSK 234
Cdd:pfam13418   1 PRAYHTST-SIPDDTI----YLFGGEGedGTLLSDLWVFDLSTNEWTR 43
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 22-59 8.99e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 34.51  E-value: 8.99e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2462531617  22 ARHGHRAVAIRELMIIFGGGNEGIA-DELHVYNTATNQW 59
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSlNSVEVYDPETNTW 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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