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Conserved domains on  [gi|2462533737|ref|XP_054228883|]
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anomalous homeobox protein isoform X2 [Homo sapiens]

Protein Classification

SIX1_SD and homeodomain domain-containing protein( domain architecture ID 11073863)

SIX1_SD and homeodomain domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 139-193 6.39e-11

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


:

Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 57.25  E-value: 6.39e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462533737 139 KSRNFPREVREKLHN-FAVgvNTNPSKAERENLALETSLTPEQVYNWFANYRRRQR 193
Cdd:cd00086     3 KRTRFTPEQLEELEKeFEK--NPYPSREEREELAKELGLTERQVKIWFQNRRAKLK 56
SIX1_SD super family cl25175
Transcriptional regulator, SIX1, N-terminal SD domain; SIX1_SD is a family of eukaryotic ...
 93-130 1.13e-06

Transcriptional regulator, SIX1, N-terminal SD domain; SIX1_SD is a family of eukaryotic proteins, and it is found N-terminal to the Homeobox domain. As a transcription factor it lacks intrinsic activation domains and thus needs to bind to the EYA family of co-factors in order to mediate transcriptional activation. It is the SD domain that is necessary for this protein-protein interaction, binding to the C-terminal region of EYA - Eyes absent homolog proteins.


The actual alignment was detected with superfamily member pfam16878:

Pssm-ID: 465293  Cd Length: 110  Bit Score: 46.76  E-value: 1.13e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2462533737  93 ELVQLWNDIHY----RLVMRRLGvaaltPVQKFRCRKRNPPP 130
Cdd:pfam16878  74 ELQELWYEAHYkeaeKLRGRPLG-----AVDKYRLRKKFPLP 110
 
Name Accession Description Interval E-value
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 139-193 6.39e-11

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 57.25  E-value: 6.39e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462533737 139 KSRNFPREVREKLHN-FAVgvNTNPSKAERENLALETSLTPEQVYNWFANYRRRQR 193
Cdd:cd00086     3 KRTRFTPEQLEELEKeFEK--NPYPSREEREELAKELGLTERQVKIWFQNRRAKLK 56
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 139-193 1.23e-09

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 53.41  E-value: 1.23e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462533737  139 KSR-NFPREVREKLHN-FAVgvNTNPSKAERENLALETSLTPEQVYNWFANYRRRQR 193
Cdd:smart00389   3 RKRtSFTPEQLEELEKeFQK--NPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
Homeobox_KN pfam05920
Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to ...
 162-191 8.62e-08

Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to human and plants. They were first identified as TALE homeobox genes in eukaryotes, (including KNOX and MEIS genes). They have been recently classified.


Pssm-ID: 428673  Cd Length: 39  Bit Score: 47.90  E-value: 8.62e-08
                          10        20        30
                  ....*....|....*....|....*....|
gi 2462533737 162 PSKAERENLALETSLTPEQVYNWFANYRRR 191
Cdd:pfam05920  10 PSEEEKAELAKETGLSRKQISNWFINARRR 39
SIX1_SD pfam16878
Transcriptional regulator, SIX1, N-terminal SD domain; SIX1_SD is a family of eukaryotic ...
 93-130 1.13e-06

Transcriptional regulator, SIX1, N-terminal SD domain; SIX1_SD is a family of eukaryotic proteins, and it is found N-terminal to the Homeobox domain. As a transcription factor it lacks intrinsic activation domains and thus needs to bind to the EYA family of co-factors in order to mediate transcriptional activation. It is the SD domain that is necessary for this protein-protein interaction, binding to the C-terminal region of EYA - Eyes absent homolog proteins.


Pssm-ID: 465293  Cd Length: 110  Bit Score: 46.76  E-value: 1.13e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2462533737  93 ELVQLWNDIHY----RLVMRRLGvaaltPVQKFRCRKRNPPP 130
Cdd:pfam16878  74 ELQELWYEAHYkeaeKLRGRPLG-----AVDKYRLRKKFPLP 110
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
131-194 2.01e-04

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 41.27  E-value: 2.01e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462533737 131 PSLCPEGLKSRNFPREvREKLHNFAVGV-------NTNPSKAERENLALETSLTPEQVYNWFANyrRRQRA 194
Cdd:COG5576    39 MKLERKQDGSSPPKSK-RRRTTDEQLMVlerefeiNPYPSSITRIKLSLLLNMPPKSVQIWFQN--KRAKE 106
 
Name Accession Description Interval E-value
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 139-193 6.39e-11

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 57.25  E-value: 6.39e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462533737 139 KSRNFPREVREKLHN-FAVgvNTNPSKAERENLALETSLTPEQVYNWFANYRRRQR 193
Cdd:cd00086     3 KRTRFTPEQLEELEKeFEK--NPYPSREEREELAKELGLTERQVKIWFQNRRAKLK 56
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 139-193 1.23e-09

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 53.41  E-value: 1.23e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462533737  139 KSR-NFPREVREKLHN-FAVgvNTNPSKAERENLALETSLTPEQVYNWFANYRRRQR 193
Cdd:smart00389   3 RKRtSFTPEQLEELEKeFQK--NPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
Homeobox_KN pfam05920
Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to ...
 162-191 8.62e-08

Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to human and plants. They were first identified as TALE homeobox genes in eukaryotes, (including KNOX and MEIS genes). They have been recently classified.


Pssm-ID: 428673  Cd Length: 39  Bit Score: 47.90  E-value: 8.62e-08
                          10        20        30
                  ....*....|....*....|....*....|
gi 2462533737 162 PSKAERENLALETSLTPEQVYNWFANYRRR 191
Cdd:pfam05920  10 PSEEEKAELAKETGLSRKQISNWFINARRR 39
SIX1_SD pfam16878
Transcriptional regulator, SIX1, N-terminal SD domain; SIX1_SD is a family of eukaryotic ...
 93-130 1.13e-06

Transcriptional regulator, SIX1, N-terminal SD domain; SIX1_SD is a family of eukaryotic proteins, and it is found N-terminal to the Homeobox domain. As a transcription factor it lacks intrinsic activation domains and thus needs to bind to the EYA family of co-factors in order to mediate transcriptional activation. It is the SD domain that is necessary for this protein-protein interaction, binding to the C-terminal region of EYA - Eyes absent homolog proteins.


Pssm-ID: 465293  Cd Length: 110  Bit Score: 46.76  E-value: 1.13e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2462533737  93 ELVQLWNDIHY----RLVMRRLGvaaltPVQKFRCRKRNPPP 130
Cdd:pfam16878  74 ELQELWYEAHYkeaeKLRGRPLG-----AVDKYRLRKKFPLP 110
Homeodomain pfam00046
Homeodomain;
159-193 1.55e-06

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 44.80  E-value: 1.55e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2462533737 159 NTNPSKAERENLALETSLTPEQVYNWFANYRRRQR 193
Cdd:pfam00046  22 NPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWK 56
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
131-194 2.01e-04

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 41.27  E-value: 2.01e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462533737 131 PSLCPEGLKSRNFPREvREKLHNFAVGV-------NTNPSKAERENLALETSLTPEQVYNWFANyrRRQRA 194
Cdd:COG5576    39 MKLERKQDGSSPPKSK-RRRTTDEQLMVlerefeiNPYPSSITRIKLSLLLNMPPKSVQIWFQN--KRAKE 106
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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