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Conserved domains on  [gi|2462545540|ref|XP_054234610|]
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tetratricopeptide repeat protein 23 isoform X1 [Homo sapiens]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11420945)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
100-283 4.14e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 48.46  E-value: 4.14e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545540 100 KLAEAHVNLAQGYLQLkGLSLQAKQHAEKARQILANSIvppysentdvfkfsiELFHTMGRALLSLQKFKEAAENLTKAE 179
Cdd:COG0457     6 DDAEAYNNLGLAYRRL-GRYEEAIEDYEKALELDPDDA---------------EALYNLGLAYLRLGRYEEALADYEQAL 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545540 180 RLSKELlqcgriikeewieieARIRLSFAQVYQGQKKSKEALSHYQAALEYveiskgetSRECVPILRELAGVEQALGLH 259
Cdd:COG0457    70 ELDPDD---------------AEALNNLGLALQALGRYEEALEDYDKALEL--------DPDDAEALYNLGLALLELGRY 126

                         170       180
                  ....*....|....*....|....
gi 2462545540 260 DVSINHFLQAhliiLSRSPSQVEA 283
Cdd:COG0457   127 DEAIEAYERA----LELDPDDADA 146
TPR_12 pfam13424
Tetratricopeptide repeat;
329-401 2.64e-05

Tetratricopeptide repeat;


:

Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 42.37  E-value: 2.64e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462545540 329 LSIQDEFCHFLQMTGQKERATSILRESLEAKVEAFGDFSPEVAETYRLLGGADLAQGNHSGARKKLKKAITRA 401
Cdd:pfam13424   3 ATALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALALA 75
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
100-283 4.14e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 48.46  E-value: 4.14e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545540 100 KLAEAHVNLAQGYLQLkGLSLQAKQHAEKARQILANSIvppysentdvfkfsiELFHTMGRALLSLQKFKEAAENLTKAE 179
Cdd:COG0457     6 DDAEAYNNLGLAYRRL-GRYEEAIEDYEKALELDPDDA---------------EALYNLGLAYLRLGRYEEALADYEQAL 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545540 180 RLSKELlqcgriikeewieieARIRLSFAQVYQGQKKSKEALSHYQAALEYveiskgetSRECVPILRELAGVEQALGLH 259
Cdd:COG0457    70 ELDPDD---------------AEALNNLGLALQALGRYEEALEDYDKALEL--------DPDDAEALYNLGLALLELGRY 126

                         170       180
                  ....*....|....*....|....
gi 2462545540 260 DVSINHFLQAhliiLSRSPSQVEA 283
Cdd:COG0457   127 DEAIEAYERA----LELDPDDADA 146
TPR_12 pfam13424
Tetratricopeptide repeat;
329-401 2.64e-05

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 42.37  E-value: 2.64e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462545540 329 LSIQDEFCHFLQMTGQKERATSILRESLEAKVEAFGDFSPEVAETYRLLGGADLAQGNHSGARKKLKKAITRA 401
Cdd:pfam13424   3 ATALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALALA 75
TPR_12 pfam13424
Tetratricopeptide repeat;
201-269 3.18e-05

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 42.37  E-value: 3.18e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462545540 201 ARIRLSFAQVYQGQKKSKEALSHYQAALEYVEISKGETSRECVPILRELAGVEQALGLHDVSINHFLQA 269
Cdd:pfam13424   3 ATALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERA 71
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
100-283 4.14e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 48.46  E-value: 4.14e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545540 100 KLAEAHVNLAQGYLQLkGLSLQAKQHAEKARQILANSIvppysentdvfkfsiELFHTMGRALLSLQKFKEAAENLTKAE 179
Cdd:COG0457     6 DDAEAYNNLGLAYRRL-GRYEEAIEDYEKALELDPDDA---------------EALYNLGLAYLRLGRYEEALADYEQAL 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545540 180 RLSKELlqcgriikeewieieARIRLSFAQVYQGQKKSKEALSHYQAALEYveiskgetSRECVPILRELAGVEQALGLH 259
Cdd:COG0457    70 ELDPDD---------------AEALNNLGLALQALGRYEEALEDYDKALEL--------DPDDAEALYNLGLALLELGRY 126

                         170       180
                  ....*....|....*....|....
gi 2462545540 260 DVSINHFLQAhliiLSRSPSQVEA 283
Cdd:COG0457   127 DEAIEAYERA----LELDPDDADA 146
TPR_12 pfam13424
Tetratricopeptide repeat;
329-401 2.64e-05

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 42.37  E-value: 2.64e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462545540 329 LSIQDEFCHFLQMTGQKERATSILRESLEAKVEAFGDFSPEVAETYRLLGGADLAQGNHSGARKKLKKAITRA 401
Cdd:pfam13424   3 ATALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALALA 75
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 115-401 3.10e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 45.88  E-value: 3.10e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545540 115 LKGLSLQAKQHAEKARQILANsIVPPYSENtdvfkfsIELFHTMGRALLSLQKFKEAAENLTKAERLSKELLQcgriike 194
Cdd:COG2956    13 FKGLNYLLNGQPDKAIDLLEE-ALELDPET-------VEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAE------- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545540 195 ewieieARIRLsfAQVYQGQKKSKEALSHYQAALEyveiskgeTSRECVPILRELAGVEQALGLHDVSINHFLQAHLIIL 274
Cdd:COG2956    78 ------ALLEL--AQDYLKAGLLDRAEELLEKLLE--------LDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGP 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545540 275 SRSPSQVEAADSAHivahaavasgRHEHHDVAEQYFQESMAHLKDSEgmgRTKFLSIQdefchFLQMTGQKERATSILRE 354
Cdd:COG2956   142 ENAHAYCELAELYL----------EQGDYDEAIEALEKALKLDPDCA---RALLLLAE-----LYLEQGDYEEAIAALER 203

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 2462545540 355 SLEAkveafgdfSPEVAETYRLLGGADLAQGNHSGARKKLKKAITRA 401
Cdd:COG2956   204 ALEQ--------DPDYLPALPRLAELYEKLGDPEEALELLRKALELD 242
TPR_12 pfam13424
Tetratricopeptide repeat;
201-269 3.18e-05

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 42.37  E-value: 3.18e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462545540 201 ARIRLSFAQVYQGQKKSKEALSHYQAALEYVEISKGETSRECVPILRELAGVEQALGLHDVSINHFLQA 269
Cdd:pfam13424   3 ATALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERA 71
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 102-229 6.82e-05

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 45.75  E-value: 6.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545540 102 AEAHVNLAQGYLQLkGLSLQAKQHAEKARQIlansiVPPYsentdvfkfsIELFHTMGRALLSLQKFKEAAENLTKAERL 181
Cdd:COG3914   112 AEALFNLGNLLLAL-GRLEEALAALRRALAL-----NPDF----------AEAYLNLGEALRRLGRLEEAIAALRRALEL 175

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2462545540 182 SKELlqcgriikeewieieARIRLSFAQVYQGQKKSKEALSHYQAALE 229
Cdd:COG3914   176 DPDN---------------AEALNNLGNALQDLGRLEEAIAAYRRALE 208
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 46-269 7.41e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 44.72  E-value: 7.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545540  46 KLLQTALfQPPREKLHLCEEKAKSYSNSHEYKQAVHELVRCVALTRicygdshwKLAEAHVNLAQGYLQLKGLSlQAKQH 125
Cdd:COG2956    63 RIHQKLL-ERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDP--------DDAEALRLLAEIYEQEGDWE-KAIEV 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545540 126 AEKARQILANSIvppysentdvfkfsiELFHTMGRALLSLQKFKEAAENLTKAERLSKEllqcgriikeewieiEARIRL 205
Cdd:COG2956   133 LERLLKLGPENA---------------HAYCELAELYLEQGDYDEAIEALEKALKLDPD---------------CARALL 182

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462545540 206 SFAQVYQGQKKSKEALSHYQAALEYveiskgetSRECVPILRELAGVEQALGLHDVSINHFLQA 269
Cdd:COG2956   183 LLAELYLEQGDYEEAIAALERALEQ--------DPDYLPALPRLAELYEKLGDPEEALELLRKA 238
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 112-269 1.03e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 39.40  E-value: 1.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545540 112 YLQLKGLSLQAKQHAEKARQILaNSIVPPYSENtdvfkfsIELFHTMGRALLSLQKFKEAAENLTKAERLSKEllqcgri 191
Cdd:COG4783     6 ALYALAQALLLAGDYDEAEALL-EKALELDPDN-------PEAFALLGEILLQLGDLDEAIVLLHEALELDPD------- 70

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462545540 192 ikeewieiEARIRLSFAQVYQGQKKSKEALSHYQAALEYveiskgetSRECVPILRELAGVEQALGLHDVSINHFLQA 269
Cdd:COG4783    71 --------EPEARLNLGLALLKAGDYDEALALLEKALKL--------DPEHPEAYLRLARAYRALGRPDEAIAALEKA 132
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 102-229 2.32e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 38.63  E-value: 2.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545540 102 AEAHVNLAQGYLQLKGLSlQAKQHAEKARQILANSIvppysentdvfkfsiELFHTMGRALLSLQKFKEAAENLTKAERL 181
Cdd:COG4783    38 PEAFALLGEILLQLGDLD-EAIVLLHEALELDPDEP---------------EARLNLGLALLKAGDYDEALALLEKALKL 101

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2462545540 182 SKEllqcgriikeewieiEARIRLSFAQVYQGQKKSKEALSHYQAALE 229
Cdd:COG4783   102 DPE---------------HPEAYLRLARAYRALGRPDEAIAALEKALE 134
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
67-230 3.77e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 39.22  E-value: 3.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545540  67 AKSYSNSHEYKQAVHELVRCVALtricygdsHWKLAEAHVNLAQGYLQLkGLSLQAKQHAEKARQILANSIvppysentd 146
Cdd:COG0457    49 GLAYLRLGRYEEALADYEQALEL--------DPDDAEALNNLGLALQAL-GRYEEALEDYDKALELDPDDA--------- 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545540 147 vfkfsiELFHTMGRALLSLQKFKEAAENLTKAERLSKELlqcgriikeewieieARIRLSFAQVYQGQKKSKEALSHYQA 226
Cdd:COG0457   111 ------EALYNLGLALLELGRYDEAIEAYERALELDPDD---------------ADALYNLGIALEKLGRYEEALELLEK 169


                  ....
gi 2462545540 227 ALEY 230
Cdd:COG0457   170 LEAA 173
TPR_12 pfam13424
Tetratricopeptide repeat;
156-229 3.89e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 36.21  E-value: 3.89e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462545540 156 HTMGRALLSLQKFKEAAENLTKAERLSKELLQCGRIIKeewieieARIRLSFAQVYQGQKKSKEALSHYQAALE 229
Cdd:pfam13424   7 NNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLT-------ATTLLNLGRLYLELGRYEEALELLERALA 73
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 102-229 5.48e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 37.29  E-value: 5.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545540 102 AEAHVNLAQGYLQLkGLSLQAKQHAEKARQILANsivppysentdvfkfSIELFHTMGRALLSLQKFKEAAENLTKAERL 181
Cdd:COG4235    17 AEGWLLLGRAYLRL-GRYDEALAAYEKALRLDPD---------------NADALLDLAEALLAAGDTEEAEELLERALAL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2462545540 182 SKEllqcgriikeewieiEARIRLSFAQVYQGQKKSKEALSHYQAALE 229
Cdd:COG4235    81 DPD---------------NPEALYLLGLAAFQQGDYAEAIAAWQKLLA 113
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 151-229 8.67e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 36.52  E-value: 8.67e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462545540 151 SIELFHTMGRALLSLQKFKEAAENLTKAERLSKEllqcgriikeewieiEARIRLSFAQVYQGQKKSKEALSHYQAALE 229
Cdd:COG4235    16 DAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPD---------------NADALLDLAEALLAAGDTEEAEELLERALA 79
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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