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Conserved domains on  [gi|4504489|ref|NP_000403|]
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histidine-rich glycoprotein precursor [Homo sapiens]

Protein Classification

cystatin family protein( domain architecture ID 11249387)

cystatin family protein similar to cystatins which are a family of cysteine protease inhibitors

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 21-127 6.48e-15

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


:

Pssm-ID: 214484  Cd Length: 107  Bit Score: 70.53  E-value: 6.48e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504489      21 PTDCSAVEPEAEKALDLINKRRRDGYLFQLLRIADAHlDRVENTTVYYLVLDVQESDCSVLSRKyWNDCEPPDSRRpsei 100
Cdd:smart00043  10 PPNDPEVQEAADFAVAEYNKKSNDKYELRVIKVVSAK-SQVVAGTNYYLKVEVGETNCKKLSVD-LENCPFLDQGE---- 83

                           90       100
                   ....*....|....*....|....*..
gi 4504489     101 viGQCKVIATRHSHEsQDLRVIDFNCT 127
Cdd:smart00043  84 --KFCTAKVWEKPWE-NKIKLVEFKCT 107
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 144-242 5.10e-10

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


:

Pssm-ID: 214484  Cd Length: 107  Bit Score: 56.67  E-value: 5.10e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504489     144 LIDFFEDTERYRKQANKALEKYKEENDDfaSFRVDRIERV-ARVRGGEGTGYFVDFSVR--NCPRH-HFPRHPNVF---- 215
Cdd:smart00043   6 PSDVPPNDPEVQEAADFAVAEYNKKSND--KYELRVIKVVsAKSQVVAGTNYYLKVEVGetNCKKLsVDLENCPFLdqge 83

                           90       100
                   ....*....|....*....|....*..
gi 4504489     216 GFCRADLFYDVEaldLESPKNLVINCE 242
Cdd:smart00043  84 KFCTAKVWEKPW---ENKIKLVEFKCT 107
 
Name Accession Description Interval E-value
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 21-127 6.48e-15

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 70.53  E-value: 6.48e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504489      21 PTDCSAVEPEAEKALDLINKRRRDGYLFQLLRIADAHlDRVENTTVYYLVLDVQESDCSVLSRKyWNDCEPPDSRRpsei 100
Cdd:smart00043  10 PPNDPEVQEAADFAVAEYNKKSNDKYELRVIKVVSAK-SQVVAGTNYYLKVEVGETNCKKLSVD-LENCPFLDQGE---- 83

                           90       100
                   ....*....|....*....|....*..
gi 4504489     101 viGQCKVIATRHSHEsQDLRVIDFNCT 127
Cdd:smart00043  84 --KFCTAKVWEKPWE-NKIKLVEFKCT 107
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 16-126 1.34e-13

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 66.73  E-value: 1.34e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504489   16 SCAVSPTDCSAVEPEAEKALDLINKRRRDGYlFQLLRIADAHLDRVENtTVYYLVLDVQESDCSVLSrkywNDCEPPDSR 95
Cdd:cd00042   2 GPSDIPANDPEVQELADFAVAEYNKKSNDKY-LEFFKVLSAKSQVVAG-TNYYITVEAGDTNCKKSS----VPLDCPDCK 75

                        90       100       110
                ....*....|....*....|....*....|.
gi 4504489   96 RPSEIVIGQCKVIATRHSHEsQDLRVIDFNC 126
Cdd:cd00042  76 LLEEGKKKFCTAKVWEKPWE-NFKELLSFKC 105
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 144-242 5.10e-10

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 56.67  E-value: 5.10e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504489     144 LIDFFEDTERYRKQANKALEKYKEENDDfaSFRVDRIERV-ARVRGGEGTGYFVDFSVR--NCPRH-HFPRHPNVF---- 215
Cdd:smart00043   6 PSDVPPNDPEVQEAADFAVAEYNKKSND--KYELRVIKVVsAKSQVVAGTNYYLKVEVGetNCKKLsVDLENCPFLdqge 83

                           90       100
                   ....*....|....*....|....*..
gi 4504489     216 GFCRADLFYDVEaldLESPKNLVINCE 242
Cdd:smart00043  84 KFCTAKVWEKPW---ENKIKLVEFKCT 107
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 144-206 5.93e-03

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 36.16  E-value: 5.93e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4504489    144 LIDFFEDTERYRKQANKALEKYKEENDDFaSFRVDRIERVARVRGGeGTGYFVDFSVR--NCPRH 206
Cdd:pfam00031   3 LSPIPDNSPELQEALDFALAEYNAKTDNY-YFELVEVKRAKSQVVA-GTNYFIKVEVGetDCSKS 65
 
Name Accession Description Interval E-value
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 21-127 6.48e-15

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 70.53  E-value: 6.48e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504489      21 PTDCSAVEPEAEKALDLINKRRRDGYLFQLLRIADAHlDRVENTTVYYLVLDVQESDCSVLSRKyWNDCEPPDSRRpsei 100
Cdd:smart00043  10 PPNDPEVQEAADFAVAEYNKKSNDKYELRVIKVVSAK-SQVVAGTNYYLKVEVGETNCKKLSVD-LENCPFLDQGE---- 83

                           90       100
                   ....*....|....*....|....*..
gi 4504489     101 viGQCKVIATRHSHEsQDLRVIDFNCT 127
Cdd:smart00043  84 --KFCTAKVWEKPWE-NKIKLVEFKCT 107
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 16-126 1.34e-13

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 66.73  E-value: 1.34e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504489   16 SCAVSPTDCSAVEPEAEKALDLINKRRRDGYlFQLLRIADAHLDRVENtTVYYLVLDVQESDCSVLSrkywNDCEPPDSR 95
Cdd:cd00042   2 GPSDIPANDPEVQELADFAVAEYNKKSNDKY-LEFFKVLSAKSQVVAG-TNYYITVEAGDTNCKKSS----VPLDCPDCK 75

                        90       100       110
                ....*....|....*....|....*....|.
gi 4504489   96 RPSEIVIGQCKVIATRHSHEsQDLRVIDFNC 126
Cdd:cd00042  76 LLEEGKKKFCTAKVWEKPWE-NFKELLSFKC 105
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 144-242 5.10e-10

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 56.67  E-value: 5.10e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504489     144 LIDFFEDTERYRKQANKALEKYKEENDDfaSFRVDRIERV-ARVRGGEGTGYFVDFSVR--NCPRH-HFPRHPNVF---- 215
Cdd:smart00043   6 PSDVPPNDPEVQEAADFAVAEYNKKSND--KYELRVIKVVsAKSQVVAGTNYYLKVEVGetNCKKLsVDLENCPFLdqge 83

                           90       100
                   ....*....|....*....|....*..
gi 4504489     216 GFCRADLFYDVEaldLESPKNLVINCE 242
Cdd:smart00043  84 KFCTAKVWEKPW---ENKIKLVEFKCT 107
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 144-206 5.93e-03

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 36.16  E-value: 5.93e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4504489    144 LIDFFEDTERYRKQANKALEKYKEENDDFaSFRVDRIERVARVRGGeGTGYFVDFSVR--NCPRH 206
Cdd:pfam00031   3 LSPIPDNSPELQEALDFALAEYNAKTDNY-YFELVEVKRAKSQVVA-GTNYFIKVEVGetDCSKS 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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