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Conserved domains on  [gi|9945304|ref|NP_000719|]
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calcitonin gene-related peptide 2 precursor [Homo sapiens]

Protein Classification

adrenomedullin/calcitonin family protein( domain architecture ID 11989841)

adrenomedullin/calcitonin family protein similar to human calcitonin that causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Calc_CGRP_IAPP pfam00214
Calcitonin / CGRP / IAPP family;
1-122 3.21e-61

Calcitonin / CGRP / IAPP family;


:

Pssm-ID: 459715 [Multi-domain]  Cd Length: 130  Bit Score: 183.80  E-value: 3.21e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945304      1 MGFRKFSPFLALSILVLYQAGSLQAAPFRSALESSPDPATLSKEDARL----LLAALVQDYVQMKASELKQEQ--ETQGS 74
Cdd:pfam00214   1 MGFWKFSPFLLLSILLLYQAGSLQAAPFRSALESSPDPATLSEEESRLkkskLLAALVKDYVQMKAEELEQEQvrETEGS 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 9945304     75 SSAA--QKRACNTATCVTHRLAGLLSRSGGMVKSNFVPTNVGSKAFGRRR 122
Cdd:pfam00214  81 SLTHirQKRGCNLATCVTHRLAHFLSRSGNKVKDNFAPTNVGPKGYGRRR 130
 
Name Accession Description Interval E-value
Calc_CGRP_IAPP pfam00214
Calcitonin / CGRP / IAPP family;
1-122 3.21e-61

Calcitonin / CGRP / IAPP family;


Pssm-ID: 459715 [Multi-domain]  Cd Length: 130  Bit Score: 183.80  E-value: 3.21e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945304      1 MGFRKFSPFLALSILVLYQAGSLQAAPFRSALESSPDPATLSKEDARL----LLAALVQDYVQMKASELKQEQ--ETQGS 74
Cdd:pfam00214   1 MGFWKFSPFLLLSILLLYQAGSLQAAPFRSALESSPDPATLSEEESRLkkskLLAALVKDYVQMKAEELEQEQvrETEGS 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 9945304     75 SSAA--QKRACNTATCVTHRLAGLLSRSGGMVKSNFVPTNVGSKAFGRRR 122
Cdd:pfam00214  81 SLTHirQKRGCNLATCVTHRLAHFLSRSGNKVKDNFAPTNVGPKGYGRRR 130
CALCITONIN smart00113
calcitonin; This family is formed by calcitonin, the calcitonin gene-related peptide, and ...
 80-122 8.05e-14

calcitonin; This family is formed by calcitonin, the calcitonin gene-related peptide, and amylin. They are short polypeptide hormones.


Pssm-ID: 128423  Cd Length: 38  Bit Score: 60.62  E-value: 8.05e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 9945304      80 KRACNTATCVTHRLAGLLSRSGGmvksnFVPTNVGSKAFGRRR 122
Cdd:smart00113   1 KRCCNLSTCVLGRLADDLNRSHT-----YSPTNVGSGTPGKKR 38
 
Name Accession Description Interval E-value
Calc_CGRP_IAPP pfam00214
Calcitonin / CGRP / IAPP family;
1-122 3.21e-61

Calcitonin / CGRP / IAPP family;


Pssm-ID: 459715 [Multi-domain]  Cd Length: 130  Bit Score: 183.80  E-value: 3.21e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945304      1 MGFRKFSPFLALSILVLYQAGSLQAAPFRSALESSPDPATLSKEDARL----LLAALVQDYVQMKASELKQEQ--ETQGS 74
Cdd:pfam00214   1 MGFWKFSPFLLLSILLLYQAGSLQAAPFRSALESSPDPATLSEEESRLkkskLLAALVKDYVQMKAEELEQEQvrETEGS 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 9945304     75 SSAA--QKRACNTATCVTHRLAGLLSRSGGMVKSNFVPTNVGSKAFGRRR 122
Cdd:pfam00214  81 SLTHirQKRGCNLATCVTHRLAHFLSRSGNKVKDNFAPTNVGPKGYGRRR 130
CALCITONIN smart00113
calcitonin; This family is formed by calcitonin, the calcitonin gene-related peptide, and ...
 80-122 8.05e-14

calcitonin; This family is formed by calcitonin, the calcitonin gene-related peptide, and amylin. They are short polypeptide hormones.


Pssm-ID: 128423  Cd Length: 38  Bit Score: 60.62  E-value: 8.05e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 9945304      80 KRACNTATCVTHRLAGLLSRSGGmvksnFVPTNVGSKAFGRRR 122
Cdd:smart00113   1 KRCCNLSTCVLGRLADDLNRSHT-----YSPTNVGSGTPGKKR 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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