|
Name |
Accession |
Description |
Interval |
E-value |
| Eukaryotic_PFK |
cd00764 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
79-823 |
0e+00 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.
Pssm-ID: 238389 [Multi-domain] Cd Length: 762 Bit Score: 1425.75 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 79 GMNAAVRAVTRMGIYVGAKVFLIYEGYEGLVEGGENIKQANWLSVSNIIQLGGTIIGSARCKAFTTREGRRAAAYNLVQH 158
Cdd:cd00764 17 GMNAAVRAVVRMGIYVGAKVFFVYEGYEGLVKGGDYIKQAEWESVSNWLQEGGTIIGSARCKEFREREGRLQAAYNLIQR 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 159 GITNLCVIGGDGSLTGANIFRSEWGSLLEELVAEGKISETTARTYSHLNIAGLVGSIDNDFCGTDMTIGTDSALHRIMEV 238
Cdd:cd00764 97 GITNLCVIGGDGSLTGADLFRSEWPSLLEELVKDGKITEEEVAKYQHLNIVGMVGSIDNDFCGTDMTIGTDSALHRICEV 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 239 IDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEDGWENFMCERLGETRSRGSRLNIIIIAEGAID 318
Cdd:cd00764 177 VDAITTTAQSHQRTFVLEVMGRHCGYLALVSGLATGADWIFIPERPPEDGWEDQMCRRLSEHRSRGKRLNIIIVAEGAID 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 319 RNGKPISSSYVKDLVVQRLGFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEAVMALLEATPDTPACVVTLSGNQSVRLPL 398
Cdd:cd00764 257 DQLKPITSEDVKDLVVERLGLDTRVTTLGHVQRGGTPSAFDRILASLMGVEAVMALLEATPDTPACVVSLNGNKAVRLPL 336
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 399 MECVQMTKEVQKAMDDKRFDEATQLRGGSFENNWNIYKLLAHQKPPK--EKSNFSLAILNVGAPAAGMNAAVRSAVRTGI 476
Cdd:cd00764 337 MECVQLTKDVQKAMDEKRFDEAAALRGKSFDKNWNLYKLLAIELPQPlpEKTNLNIAIVNVGAPAAGMNAAVRSAVRYGL 416
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 477 SHGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSMLGTKRTLPKGQLESIVENIRIYGIHALLVVGGFEAYEGVLQ 556
Cdd:cd00764 417 AHGHRPYAIYDGFEGLAKGQIVELGWIDVGGWTGRGGSELGTKRTLPKKDLETIAYNFQKYGIDGLIIVGGFEAYKGLLQ 496
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 557 LVEARGRYEELCIVMCVIPATISNNVPGTDFSLGSDTAVNAAMESCDRIKQSASGTKRRVFIVETMGGYCGYLATVTGIA 636
Cdd:cd00764 497 LREAREQYEEFCIPMVLIPATVSNNVPGTDFSLGSDTALNALMKYCDRIKQSASGTKRRVFIVETMGGYCGYLATMTGLA 576
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 637 VGADAAYVFEDPFNIHDLKVNVEHMTEKMKTDIQRGLVLRNEKCHDYYTTEFLYNLYSSEGKGVFDCRTNVLGHLQQGGA 716
Cdd:cd00764 577 VGADAAYVFEEPFNIRDLQENVEHLTEKMKTTIGRGLVLRNEKCNENYTTVFTYELYSEEGKGVFDCRTNVLGHVQQGGA 656
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 717 PTPFDRNYGTKLGVKAMLWLSEKLREVYRKGRVFANAPDSACVIGLKKKAVAFSPVTELKKDTdFEHRMPREQWWLSLRL 796
Cdd:cd00764 657 PSPFDRNFGTKFAVKAMKWIEQKLKENYAAGNEFANDPDFNCVNGVKKYAVLFEPVEELKQTT-FEHRIPKEQWWLSLRP 735
|
730 740
....*....|....*....|....*..
gi 590122057 797 MLKMLAQYRISMAAYVSGELEHVTRRT 823
Cdd:cd00764 736 LLKILAKYKISADISDHGQLEHVTRGQ 762
|
|
| 6PF1K_euk |
TIGR02478 |
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ... |
79-805 |
0e+00 |
|
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).
Pssm-ID: 274152 [Multi-domain] Cd Length: 746 Bit Score: 1182.13 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 79 GMNAAVRAVTRMGIYVGAKVFLIYEGYEGLVEGGENIKQANWLSVSNIIQLGGTIIGSARCKAFTTREGRRAAAYNLVQH 158
Cdd:TIGR02478 14 GMNAAVRAVVRMAIYVGCRVYAIREGYQGLVDGGDNIEEAQWEDVRGILSLGGTIIGTARCKEFRERPGRLKAARNLVSN 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 159 GITNLCVIGGDGSLTGANIFRSEWGSLLEELVAEGKISETTARTYSHLNIAGLVGSIDNDFCGTDMTIGTDSALHRIMEV 238
Cdd:TIGR02478 94 GIDALVVIGGDGSLTGADLFREEWPSLLEELVDTGKITAEQAEEHRHLTIVGLVGSIDNDMCGTDMTIGADSALHRICEA 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 239 IDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEDGWENFMCERLGETRSRGSRLNIIIIAEGAID 318
Cdd:TIGR02478 174 IDAISSTAQSHQRAFVVEVMGRHCGYLALMAAIATGADYVFIPERPPEEGWEDQLCHKLKRNRKAGKRKTIVIVAEGAID 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 319 RNGKPISSSYVKDLVVQRLGFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEAVMALLEATPDTPACVVTLSGNQSVRLPL 398
Cdd:TIGR02478 254 RDLNPITSEDVKDVLVERLGLDTRITVLGHVQRGGAPSAFDRILATRQGVEAVLAVLESTPETPSPVISLRGNKIVRKPL 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 399 MECVQMTKEVQKAMDDKRFDEATQLRGGSFENNWNIYKLLAHQKPPK-----EKSNFSLAILNVGAPAAGMNAAVRSAVR 473
Cdd:TIGR02478 334 VEAVAQTKTVAKAIEEKDFDEAMRLRGREFAENLETFLFLSIPDDDKklvpsEASRLRIAIIHVGAPAGGMNAATRSAVR 413
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 474 TGISHGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSMLGTKRTLPKGQLESIVENIRIYGIHALLVVGGFEAYEG 553
Cdd:TIGR02478 414 YALARGHTVIAIHNGFSGLARHDVRELTWSDVEGWVGEGGSELGTNRSLPGDDLGTIAYYFQQHKIDGLIIIGGFEAFEA 493
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 554 VLQLVEARGRYEELCIVMCVIPATISNNVPGTDFSLGSDTAVNAAMESCDRIKQSASGTKRRVFIVETMGGYCGYLATVT 633
Cdd:TIGR02478 494 LYQLDAAREKYPAFRIPMVVIPATISNNVPGTEYSLGSDTALNEITEYCDNIKQSASASKRRVFVVETMGGYSGYLATMA 573
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 634 GIAVGADAAYVFEDPFNIHDLKVNVEHMTEKMKTDIQRGLVLRNEKCHDYYTTEFLYNLYSSEGKGVFDCRTNVLGHLQQ 713
Cdd:TIGR02478 574 GLATGADAAYIPEEGISLKDLQEDIEHLKETFAEGRAGKLILRNEKASKVYTTDFIARIISEEGKGRFDARTAVLGHMQQ 653
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 714 GGAPTPFDRNYGTKLGVKAMLWLSEKLREVYRKGRVFANaPDSACVIGLKKKAVAFSPV-TELKKDTDFEHRMPREQWWL 792
Cdd:TIGR02478 654 GGSPSPFDRVRATRLAIRAVDFIEEKIKANKHADKLSAD-DTSAVVIGIRGSNVLFTPVkQLLANETDFEHRRPKNQWWL 732
|
730
....*....|...
gi 590122057 793 SLRLMLKMLAQYR 805
Cdd:TIGR02478 733 QLRPLVRILAGRD 745
|
|
| PFK |
cd00363 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
79-433 |
3.14e-178 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. Some members evolved by gene duplication and thus have a large C-terminal/N-terminal extension comprising a second PFK domain. Generally, ATP-PFKs are allosteric homotetramers, and PPi-PFKs are dimeric and nonallosteric except for plant PPi-PFKs which are allosteric heterotetramers.
Pssm-ID: 238216 [Multi-domain] Cd Length: 338 Bit Score: 515.70 E-value: 3.14e-178
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 79 GMNAAVRAVTRMGIYVGAKVFLIYEGYEGLVEGgeNIKQANWLSVSNIIQLGGTIIGSARCKAFTTREGRRAAAYNLVQH 158
Cdd:cd00363 14 GMNAAIRGVVRSAIAEGLEVYGIYEGYAGLVEG--DIKELDWESVSDIINRGGTIIGSARCKEFRTEEGRAKAAENLKKH 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 159 GITNLCVIGGDGSLTGANIFRSEWGSlleelvaegkisettarTYSHLNIAGLVGSIDNDFCGTDMTIGTDSALHRIMEV 238
Cdd:cd00363 92 GIDALVVIGGDGSYTGADLLTEEWPS-----------------KYQGFNVIGLPGTIDNDIKGTDYTIGFDTALKTIVEA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 239 IDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEDGWENFMCERLGETRSRGSRLNIIIIAEGAID 318
Cdd:cd00363 155 IDRIRDTASSHQRTFVVEVMGRHCGDIALEAGLATGADIIFIPEEPAADEWEEEMVDVIKKRRERGKRHGIVIVAEGAID 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 319 RNGKPISSSYVKDLVVQRLGFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEAVMALLEATPDTPACVVTLSGNQSVRLPL 398
Cdd:cd00363 235 FIPKPITEKLLAKLVEERLGFDTRATVLGHVQRGGTPTAFDRILASRLGAEAVELLLEGTGGTPVGIQNLNENQVVRHPL 314
|
330 340 350
....*....|....*....|....*....|....*
gi 590122057 399 MECVQMTKEVQkamddkrfdeaTQLRGGSFENNWN 433
Cdd:cd00363 315 TEAVNMTKRVG-----------VDLEGRPFKKFAK 338
|
|
| PFK |
pfam00365 |
Phosphofructokinase; |
78-371 |
5.67e-131 |
|
Phosphofructokinase;
Pssm-ID: 459783 [Multi-domain] Cd Length: 271 Bit Score: 391.70 E-value: 5.67e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 78 GGMNAAVRAVTRMGIYVGAKVFLIYEGYEGLVEGgeNIKQANWLSVSNIIQLGGTIIGSARCKAFTTREGRRAAAYNLVQ 157
Cdd:pfam00365 12 PGMNAAIRAVVRTAIYRGHEVYGIRNGYEGLVEG--DIDELTWRDVSGILNRGGTILGTSRSKPFKTEEGREKIAENLKK 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 158 HGITNLCVIGGDGSLTGANIFRSEWGslleelvaegkisettartyshLNIAGLVGSIDNDFCGTDMTIGTDSALHRIME 237
Cdd:pfam00365 90 LGIDALVVIGGDGSLTGANKLSEERG----------------------IPVVGIPKTIDNDIPGTDYTIGFDTALNTIVE 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 238 VIDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEdgwENFMCERLgETRSRGSRLNIIIIAEGAI 317
Cdd:pfam00365 148 AIDRIRDTASSHNRVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPFD---IEELCEKI-KELRKGKRFSIIVVAEGAS 223
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 590122057 318 DrngkpisSSYVKDLVVQRLGFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEAV 371
Cdd:pfam00365 224 D-------GEFLAKLIEEGTGIETRVTVLGHVQRGGTPSAFDRILATRLGVKAV 270
|
|
| PFK |
pfam00365 |
Phosphofructokinase; |
452-733 |
6.40e-121 |
|
Phosphofructokinase;
Pssm-ID: 459783 [Multi-domain] Cd Length: 271 Bit Score: 365.51 E-value: 6.40e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 452 LAILNVGAPAAGMNAAVRSAVRTGISHGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSMLGTKRTLPKGQLES-- 529
Cdd:pfam00365 2 IGILTSGGDAPGMNAAIRAVVRTAIYRGHEVYGIRNGYEGLVEGDIDELTWRDVSGILNRGGTILGTSRSKPFKTEEGre 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 530 -IVENIRIYGIHALLVVGGFEAYEGVLQLVEARGryeelcIVMCVIPATISNNVPGTDFSLGSDTAVNAAMESCDRIKQS 608
Cdd:pfam00365 82 kIAENLKKLGIDALVVIGGDGSLTGANKLSEERG------IPVVGIPKTIDNDIPGTDYTIGFDTALNTIVEAIDRIRDT 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 609 ASGTkRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFNIHDLKVNVEHMTeKMKTDIqrgLVLRNEKCHDyytTEF 688
Cdd:pfam00365 156 ASSH-NRVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPFDIEELCEKIKELR-KGKRFS---IIVVAEGASD---GEF 227
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 590122057 689 LYNLYssEGKGVFDCRTNVLGHLQQGGAPTPFDRNYGTKLGVKAM 733
Cdd:pfam00365 228 LAKLI--EEGTGIETRVTVLGHVQRGGTPSAFDRILATRLGVKAV 270
|
|
| PfkA |
COG0205 |
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ... |
79-408 |
4.52e-112 |
|
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 439975 [Multi-domain] Cd Length: 344 Bit Score: 345.52 E-value: 4.52e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 79 GMNAAVRAVTRMGIYVGAKVFLIYEGYEGLVEGgeNIKQANWLSVSNIIQLGGTIIGSARCKAFTTREGRRAAAYNLVQH 158
Cdd:COG0205 15 GLNAAIRAVVRTAIKYGIEVYGIRDGYEGLLEG--DIIDLTREDVSGILQRGGTILGSSRSKPFKTEEGREKALENLKKL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 159 GITNLCVIGGDGSLTGANIFRSEWGslleelvaegkisettartyshLNIAGLVGSIDNDFCGTDMTIGTDSALHRIMEV 238
Cdd:COG0205 93 GIDALVVIGGDGSLDGAAKLAEEYG----------------------IPVVGIPKTIDNDLPGTDYTIGFDTAVNTAAEA 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 239 IDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEdgwENFMCERLGETRSRGSRLNIIIIAEGAID 318
Cdd:COG0205 151 IDRLRDTAASHERVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPFD---LDKLLEKLKERRKRGKGYSIIVVAEGAGD 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 319 RNGKPISSS---------------YVKDLVVQRLGFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEAVMALLEatpDTPA 383
Cdd:COG0205 228 EDGEAVLEAdtdafghvrlggigeYLAKEIEERTGIETRVTVLGHLQRGGSPSAFDRVLASRLGAAAVELLLE---GKTG 304
|
330 340
....*....|....*....|....*
gi 590122057 384 CVVTLSGNQSVRLPLMECVQMTKEV 408
Cdd:COG0205 305 VMVGIRRGEIVLVPLEEVANKEKPV 329
|
|
| PRK03202 |
PRK03202 |
ATP-dependent 6-phosphofructokinase; |
79-415 |
1.34e-110 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 235111 [Multi-domain] Cd Length: 320 Bit Score: 340.90 E-value: 1.34e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 79 GMNAAVRAVTRMGIYVGAKVFLIYEGYEGLVEGgeNIKQANWLSVSNIIQLGGTIIGSARCKAFTTREGRRAAAYNLVQH 158
Cdd:PRK03202 15 GMNAAIRAVVRTAISEGLEVYGIYDGYAGLLEG--DIVKLDLKSVSDIINRGGTILGSARFPEFKDEEGRAKAIENLKKL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 159 GITNLCVIGGDGSLTGANIFrSEWGslleelvaegkisettartyshLNIAGLVGSIDNDFCGTDMTIGTDSALHRIMEV 238
Cdd:PRK03202 93 GIDALVVIGGDGSYMGAKRL-TEHG----------------------IPVIGLPGTIDNDIAGTDYTIGFDTALNTAVEA 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 239 IDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAP--PEDgwenfMCERLGETRSRGSRLNIIIIAEGA 316
Cdd:PRK03202 150 IDRLRDTASSHERVFIVEVMGRHAGDLALHAGIAGGAEVILIPEVPfdIEE-----LCAKIKKGRERGKKHAIIVVAEGV 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 317 IDRNGkpisssyVKDLVVQRLGFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEAVMALLEATPDTpacVVTLSGNQSVRL 396
Cdd:PRK03202 225 MPAEE-------LAKEIEERTGLETRVTVLGHIQRGGSPTAFDRVLASRMGAHAVELLLEGKGGR---MVGIQNNKIVHV 294
|
330 340
....*....|....*....|
gi 590122057 397 PLMECV-QMTKEVQKAMDDK 415
Cdd:PRK03202 295 PIEEAVeNMKHPFDKDLYEL 314
|
|
| PFKA_ATP |
TIGR02482 |
6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate ... |
79-400 |
1.33e-101 |
|
6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate from ATP to fructose 6-phosphate to give fructose 1,6-bisphosphate. This represents a key control step in glycolysis. This model hits bacterial ATP-dependent 6-phosphofructokinases which lack a beta-hairpin loop present in TIGR02483 family members. TIGR02483 contains members that are ATP-dependent as well as members that are pyrophosphate-dependent. TIGR02477 represents the pyrophosphate-dependent phosphofructokinase, diphosphate--fructose-6-phosphate 1-phosphotransferase (EC 2.7.1.90). [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 213713 [Multi-domain] Cd Length: 301 Bit Score: 316.60 E-value: 1.33e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 79 GMNAAVRAVTRMGIYVGAKVFLIYEGYEGLVEGgeNIKQANWLSVSNIIQLGGTIIGSARCKAFTTREGRRAAAYNLVQH 158
Cdd:TIGR02482 13 GMNAAIRAVVRTAIYHGFEVYGIRRGYKGLING--KIEPLESKNVSGIIHRGGTILGTARCPEFKTEEVREKAVENLKKL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 159 GITNLCVIGGDGSLTGANIfrsewgslleeLVAEGKIsettartyshlNIAGLVGSIDNDFCGTDMTIGTDSALHRIMEV 238
Cdd:TIGR02482 91 GIEGLVVIGGDGSYTGAQK-----------LYEEGGI-----------PVIGLPGTIDNDIPGTDYTIGFDTALNTIIDA 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 239 IDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEA--PPEDgwenfMCERLGETRSRGSRLNIIIIAEGA 316
Cdd:TIGR02482 149 VDKIRDTATSHERAFVIEVMGRHAGDLALYAGIATGAEIIIIPEFdyDIDE-----LIQRLKEQHEAGKKHSIIIVAEGN 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 317 IDRNGKPISSSyVKDlvvqRLGFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEAVMALLEatpDTPACVVTLSGNQSVRL 396
Cdd:TIGR02482 224 IVGSAKEVAKK-IEE----KTGIETRVTVLGHTQRGGSPSAFDRVLASRLGAKAVELLLE---GKGGVMIGIQNNKIVTH 295
|
....
gi 590122057 397 PLME 400
Cdd:TIGR02482 296 PIEE 299
|
|
| Bacterial_PFK |
cd00763 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
79-412 |
6.75e-88 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent phosphofructokinases. These are allosrterically regulated homotetramers; the subunits are of about 320 amino acids.
Pssm-ID: 238388 [Multi-domain] Cd Length: 317 Bit Score: 281.22 E-value: 6.75e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 79 GMNAAVRAVTRMGIYVGAKVFLIYEGYEGLVEGgeNIKQANWLSVSNIIQLGGTIIGSARCKAFTTREGRRAAAYNLVQH 158
Cdd:cd00763 14 GMNAAIRGVVRSAIAEGLEVYGIRDGYAGLIAG--DIVPLDRYSVSDIINRGGTFLGSARFPEFKDEEGQAKAIEQLKKH 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 159 GITNLCVIGGDGSLTGAnifrsewgsllEELVAEGkisettartyshLNIAGLVGSIDNDFCGTDMTIGTDSALHRIMEV 238
Cdd:cd00763 92 GIDALVVIGGDGSYMGA-----------MRLTEHG------------FPCVGLPGTIDNDIPGTDYTIGFDTALNTVVEA 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 239 IDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAP--PEDgwenfMCERLGETRSRGSRLNIIIIAEGA 316
Cdd:cd00763 149 IDRIRDTSSSHQRISVVEVMGRHCGDIALAAGIAGGAEFIVIPEAEfdREE-----VANRIKAGIERGKKHAIVVVAEGV 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 317 IDRNGkpisssyVKDLVVQRLGFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEAVMALLEAtpdTPACVVTLSGNQSVRL 396
Cdd:cd00763 224 YDVDE-------LAKEIEEATGFETRATVLGHIQRGGSPTAFDRILASRMGAYAVELLLAG---KGGLAVGIQNEQLVHH 293
|
330
....*....|....*.
gi 590122057 397 PLMECVQMTKEVQKAM 412
Cdd:cd00763 294 DIIDAIENMKPFKKDW 309
|
|
| PFK_mixed |
TIGR02483 |
phosphofructokinase; Members of this family that are characterized, save one, are ... |
79-402 |
4.37e-70 |
|
phosphofructokinase; Members of this family that are characterized, save one, are phosphofructokinases dependent on pyrophosphate (EC 2.7.1.90) rather than ATP (EC 2.7.1.11). The exception is one of three phosphofructokinases from Streptomyces coelicolor. Family members are both bacterial and archaeal. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 274155 [Multi-domain] Cd Length: 324 Bit Score: 234.12 E-value: 4.37e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 79 GMNAAVRAVTRMGIYV-GAKVFLIYEGYEGLVEGGEnIKQANWLSVSNIIQLGGTIIGSARCKAFTT-REGRRAAAYNLV 156
Cdd:TIGR02483 13 GLNAVIRGVVRRAIAEyGWEVIGIRDGWRGLLEGDT-VPLLDLEDVRGILPRGGTILGSSRTNPFKYeEDGDDKIVANLK 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 157 QHGITNLCVIGGDGSLTGANifrsewgslleELVAEGkisettartyshLNIAGLVGSIDNDFCGTDMTIGTDSALHRIM 236
Cdd:TIGR02483 92 ELGLDALIAIGGDGTLGIAR-----------RLADKG------------LPVVGVPKTIDNDLEATDYTFGFDTAVEIAT 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 237 EVIDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEdgWENfMCERLGETRSRGSRLNIIIIAEGA 316
Cdd:TIGR02483 149 EALDRLHTTAESHHRVMVVEVMGRHAGWIALHSGIAGGADVILIPEIPFD--IDS-VCEKVRERFARGKRFAIVVVAEGA 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 317 IDRNGKPISSSYVKD----------------LVVQRLGFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEAVMALLEATPD 380
Cdd:TIGR02483 226 KPKGGEMVVQEGVKDafghvrlggignwlaeEIERRTGIETRATVLGHLQRGGSPSAFDRVLATRFGVAAVDLVHEGQFG 305
|
330 340
....*....|....*....|..
gi 590122057 381 TpacVVTLSGNQSVRLPLMECV 402
Cdd:TIGR02483 306 H---MVALRGTDIVYVPIAEAV 324
|
|
| PfkA |
COG0205 |
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ... |
452-738 |
1.95e-67 |
|
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 439975 [Multi-domain] Cd Length: 344 Bit Score: 227.65 E-value: 1.95e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 452 LAILNVGAPAAGMNAAVRSAVRTGISHGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSMLGTKRTLPK---GQLE 528
Cdd:COG0205 4 IGILTSGGDAPGLNAAIRAVVRTAIKYGIEVYGIRDGYEGLLEGDIIDLTREDVSGILQRGGTILGSSRSKPFkteEGRE 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 529 SIVENIRIYGIHALLVVGGFEAYEGVLQLVEARGryeelciVMCV-IPATISNNVPGTDFSLGSDTAVNAAMESCDRIKQ 607
Cdd:COG0205 84 KALENLKKLGIDALVVIGGDGSLDGAAKLAEEYG-------IPVVgIPKTIDNDLPGTDYTIGFDTAVNTAAEAIDRLRD 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 608 SASGTkRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFNIHDLkvnVEHMTEKMKTDIQRGLVL--------RNEK 679
Cdd:COG0205 157 TAASH-ERVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPFDLDKL---LEKLKERRKRGKGYSIIVvaegagdeDGEA 232
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 590122057 680 CHDYYTTEFLYNLYSSEGKGV---------FDCRTNVLGHLQQGGAPTPFDRNYGTKLGVKAMLWLSE 738
Cdd:COG0205 233 VLEADTDAFGHVRLGGIGEYLakeieertgIETRVTVLGHLQRGGSPSAFDRVLASRLGAAAVELLLE 300
|
|
| PRK03202 |
PRK03202 |
ATP-dependent 6-phosphofructokinase; |
452-732 |
3.43e-66 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 235111 [Multi-domain] Cd Length: 320 Bit Score: 223.42 E-value: 3.43e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 452 LAILNVGAPAAGMNAAVRSAVRTGISHGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSMLGTKRT----LPKGQL 527
Cdd:PRK03202 4 IGVLTSGGDAPGMNAAIRAVVRTAISEGLEVYGIYDGYAGLLEGDIVKLDLKSVSDIINRGGTILGSARFpefkDEEGRA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 528 EsIVENIRIYGIHALLVVGGFEAYEGVLQLVEARgryeelciVMCV-IPATISNNVPGTDFSLGSDTAVNAAMESCDRIK 606
Cdd:PRK03202 84 K-AIENLKKLGIDALVVIGGDGSYMGAKRLTEHG--------IPVIgLPGTIDNDIAGTDYTIGFDTALNTAVEAIDRLR 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 607 QSASgTKRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFNIHDLkvnVEHMTEKMKTDIQRGLVLRNEKCHD--YY 684
Cdd:PRK03202 155 DTAS-SHERVFIVEVMGRHAGDLALHAGIAGGAEVILIPEVPFDIEEL---CAKIKKGRERGKKHAIIVVAEGVMPaeEL 230
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 590122057 685 TTEFlynlyssEGKGVFDCRTNVLGHLQQGGAPTPFDRNYGTKLGVKA 732
Cdd:PRK03202 231 AKEI-------EERTGLETRVTVLGHIQRGGSPTAFDRVLASRMGAHA 271
|
|
| PFK |
cd00363 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
451-775 |
5.20e-60 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. Some members evolved by gene duplication and thus have a large C-terminal/N-terminal extension comprising a second PFK domain. Generally, ATP-PFKs are allosteric homotetramers, and PPi-PFKs are dimeric and nonallosteric except for plant PPi-PFKs which are allosteric heterotetramers.
Pssm-ID: 238216 [Multi-domain] Cd Length: 338 Bit Score: 207.15 E-value: 5.20e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 451 SLAILNVGAPAAGMNAAVRSAVRTGISHGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSMLGTKRT----LPKGQ 526
Cdd:cd00363 2 KIGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIYEGYAGLVEGDIKELDWESVSDIINRGGTIIGSARCkefrTEEGR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 527 LESIvENIRIYGIHALLVVGGFEAYEGVLQLVE-ARGRYEELCIVMCviPATISNNVPGTDFSLGSDTAVNAAMESCDRI 605
Cdd:cd00363 82 AKAA-ENLKKHGIDALVVIGGDGSYTGADLLTEeWPSKYQGFNVIGL--PGTIDNDIKGTDYTIGFDTALKTIVEAIDRI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 606 KQSASgTKRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFNihdlKVNVEHMTEKMKTDIQRG----LVLRNEKch 681
Cdd:cd00363 159 RDTAS-SHQRTFVVEVMGRHCGDIALEAGLATGADIIFIPEEPAA----DEWEEEMVDVIKKRRERGkrhgIVIVAEG-- 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 682 dyyTTEFLYNLYSSEG-------KGVFDCRTNVLGHLQQGGAPTPFDRNYGTKLGVKAMLWLSEKLREVyrkgrvfanap 754
Cdd:cd00363 232 ---AIDFIPKPITEKLlaklveeRLGFDTRATVLGHVQRGGTPTAFDRILASRLGAEAVELLLEGTGGT----------- 297
|
330 340
....*....|....*....|.
gi 590122057 755 dSACVIGLKKKAVAFSPVTEL 775
Cdd:cd00363 298 -PVGIQNLNENQVVRHPLTEA 317
|
|
| Bacterial_PFK |
cd00763 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
452-732 |
1.46e-57 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent phosphofructokinases. These are allosrterically regulated homotetramers; the subunits are of about 320 amino acids.
Pssm-ID: 238388 [Multi-domain] Cd Length: 317 Bit Score: 199.56 E-value: 1.46e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 452 LAILNVGAPAAGMNAAVRSAVRTGISHGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSMLGTKR----TLPKGQL 527
Cdd:cd00763 3 IGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIRDGYAGLIAGDIVPLDRYSVSDIINRGGTFLGSARfpefKDEEGQA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 528 ESIvENIRIYGIHALLVVGGFEAYEGVLQLVEARgryeelciVMCV-IPATISNNVPGTDFSLGSDTAVNAAMESCDRIK 606
Cdd:cd00763 83 KAI-EQLKKHGIDALVVIGGDGSYMGAMRLTEHG--------FPCVgLPGTIDNDIPGTDYTIGFDTALNTVVEAIDRIR 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 607 QSASgTKRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFNIHDLKVNVEHMTEKMKtdiQRGLVLRNEkcHDYYTT 686
Cdd:cd00763 154 DTSS-SHQRISVVEVMGRHCGDIALAAGIAGGAEFIVIPEAEFDREEVANRIKAGIERGK---KHAIVVVAE--GVYDVD 227
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 590122057 687 EFLYNLyssEGKGVFDCRTNVLGHLQQGGAPTPFDRNYGTKLGVKA 732
Cdd:cd00763 228 ELAKEI---EEATGFETRATVLGHIQRGGSPTAFDRILASRMGAYA 270
|
|
| 6PF1K_euk |
TIGR02478 |
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ... |
78-392 |
4.90e-51 |
|
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).
Pssm-ID: 274152 [Multi-domain] Cd Length: 746 Bit Score: 191.40 E-value: 4.90e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 78 GGMNAAVRAVTRMGIYVGAKVFLIYEGYEGLVEGGenIKQANWLSVSNIIQLGGTIIGSARCkafTTREGRRAAAYNLVQ 157
Cdd:TIGR02478 402 GGMNAATRSAVRYALARGHTVIAIHNGFSGLARHD--VRELTWSDVEGWVGEGGSELGTNRS---LPGDDLGTIAYYFQQ 476
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 158 HGITNLCVIGGDGSLTGANIFRsewgslleelvaegkisetTART-YSHLNI--AGLVGSIDNDFCGTDMTIGTDSALHR 234
Cdd:TIGR02478 477 HKIDGLIIIGGFEAFEALYQLD-------------------AAREkYPAFRIpmVVIPATISNNVPGTEYSLGSDTALNE 537
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 235 IMEVIDAITTTAQ-SHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAP-PEDGWEN---FMCERLGETRSRGsrlnI 309
Cdd:TIGR02478 538 ITEYCDNIKQSASaSKRRVFVVETMGGYSGYLATMAGLATGADAAYIPEEGiSLKDLQEdieHLKETFAEGRAGK----L 613
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 310 IIIAEGAIdrngKPISSSYVKDLVVQ--RLGFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEAVMALLEATP-------- 379
Cdd:TIGR02478 614 ILRNEKAS----KVYTTDFIARIISEegKGRFDARTAVLGHMQQGGSPSPFDRVRATRLAIRAVDFIEEKIKankhadkl 689
|
330
....*....|....*.
gi 590122057 380 ---DTPACVVTLSGNQ 392
Cdd:TIGR02478 690 sadDTSAVVIGIRGSN 705
|
|
| PRK14071 |
PRK14071 |
ATP-dependent 6-phosphofructokinase; |
78-409 |
7.74e-49 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 184487 [Multi-domain] Cd Length: 360 Bit Score: 176.80 E-value: 7.74e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 78 GGMNAAVRAVTR--MGIYvGAKVFLIYEGYEGLVEGGENIKQANWLSVSNIIQLGGTIIGSARcK----AFTTREG---- 147
Cdd:PRK14071 17 AGLNAVIRAVVHraRGTY-GWEVIGIRDATQGLMARPPQYIELDLDQVDDLLRMGGTILGTTN-KgdpfAFPMPDGslrd 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 148 RRA---AAYNlvQHGITNLCVIGGDGSLtganifrsewgSLLEELVAEGKIsettartyshlNIAGLVGSIDNDFCGTDM 224
Cdd:PRK14071 95 RSQeiiDGYH--SLGLDALIGIGGDGSL-----------AILRRLAQQGGI-----------NLVGIPKTIDNDVGATEV 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 225 TIGTDSALHRIMEVIDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEdgWENfMCERLGETRSRG 304
Cdd:PRK14071 151 SIGFDTAVNIATEALDRLHFTAASHNRVMILEVMGRDAGHIALAAGIAGGADVILIPEIPYT--LEN-VCKKIRERQEEG 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 305 SRLNIIIIAEGAIDRNGKPIS-------------SSYVKDLVVQRLGFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEAV 371
Cdd:PRK14071 228 KNFCLVVVSEAVRTEEGEQVTktqalgedryggiGQYLAEQIAERTGAETRVTVLGHIQRGGIPSPRDRLLASAFGVAAV 307
|
330 340 350
....*....|....*....|....*....|....*...
gi 590122057 372 MALLEATPDTpacVVTLSGNQSVRLPLMECVQMTKEVQ 409
Cdd:PRK14071 308 DLIAQGKFDR---MVAWQNRQVVSVPIAEAIATYRAVD 342
|
|
| 6PF1K_euk |
TIGR02478 |
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ... |
452-785 |
1.43e-48 |
|
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).
Pssm-ID: 274152 [Multi-domain] Cd Length: 746 Bit Score: 184.08 E-value: 1.43e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 452 LAILNVGAPAAGMNAAVRSAVRTGISHGHTVYVVHDGFEGLAKGQ--VQEVGWHDVAGWLGRGGSMLGTKRTLP----KG 525
Cdd:TIGR02478 3 IAVLTSGGDAQGMNAAVRAVVRMAIYVGCRVYAIREGYQGLVDGGdnIEEAQWEDVRGILSLGGTIIGTARCKEfrerPG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 526 QLESiVENIRIYGIHALLVVGGFEAYEG-----------VLQLV-------EARGRYEELCIVMCVipATISNNVPGTDF 587
Cdd:TIGR02478 83 RLKA-ARNLVSNGIDALVVIGGDGSLTGadlfreewpslLEELVdtgkitaEQAEEHRHLTIVGLV--GSIDNDMCGTDM 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 588 SLGSDTAVNAAMESCDRIKQSASGTKrRVFIVETMGGYCGYLATVTGIAVGADaaYVF--EDPfnihdLKVN-VEHMTEK 664
Cdd:TIGR02478 160 TIGADSALHRICEAIDAISSTAQSHQ-RAFVVEVMGRHCGYLALMAAIATGAD--YVFipERP-----PEEGwEDQLCHK 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 665 MKTDIQRG----LVLRNEKCHD----YYTTEFLYNLYSSEGKgvFDCRTNVLGHLQQGGAPTPFDRNYGTKLGVKAMLWL 736
Cdd:TIGR02478 232 LKRNRKAGkrktIVIVAEGAIDrdlnPITSEDVKDVLVERLG--LDTRITVLGHVQRGGAPSAFDRILATRQGVEAVLAV 309
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 590122057 737 SEKLREvyrkgrvfanAPdsACVIGLKK---------KAVAFS-PVTELKKDTDFEHRM 785
Cdd:TIGR02478 310 LESTPE----------TP--SPVISLRGnkivrkplvEAVAQTkTVAKAIEEKDFDEAM 356
|
|
| Eukaryotic_PFK |
cd00764 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
451-795 |
3.35e-44 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.
Pssm-ID: 238389 [Multi-domain] Cd Length: 762 Bit Score: 171.16 E-value: 3.35e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 451 SLAILNVGAPAAGMNAAVRSAVRTGISHGHTVYVVHDGFEGLAKG--QVQEVGWHDVAGWLGRGGSMLGTKR----TLPK 524
Cdd:cd00764 5 AIAVLTSGGDAQGMNAAVRAVVRMGIYVGAKVFFVYEGYEGLVKGgdYIKQAEWESVSNWLQEGGTIIGSARckefRERE 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 525 GQLESIVeNIRIYGIHALLVVGGFEAYEG-----------VLQLV-------EARGRYEELCIVMCVipATISNNVPGTD 586
Cdd:cd00764 85 GRLQAAY-NLIQRGITNLCVIGGDGSLTGadlfrsewpslLEELVkdgkiteEEVAKYQHLNIVGMV--GSIDNDFCGTD 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 587 FSLGSDTAVNAAMESCDRIKQSASgTKRRVFIVETMGGYCGYLATVTGIAVGADaaYVF------EDPFNIHDLKVNVEH 660
Cdd:cd00764 162 MTIGTDSALHRICEVVDAITTTAQ-SHQRTFVLEVMGRHCGYLALVSGLATGAD--WIFiperppEDGWEDQMCRRLSEH 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 661 MTEKMKTDI---QRGLVLRNEKChdyYTTEFLYNLYSSEGKgvFDCRTNVLGHLQQGGAPTPFDRNYGTKLGVKAMLWLS 737
Cdd:cd00764 239 RSRGKRLNIiivAEGAIDDQLKP---ITSEDVKDLVVERLG--LDTRVTTLGHVQRGGTPSAFDRILASLMGVEAVMALL 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 590122057 738 EklrevyrkgrvfaNAPDS-ACVIGLKKKAVAFSPVTE---LKKDTDFEHRMPREQWWLSLR 795
Cdd:cd00764 314 E-------------ATPDTpACVVSLNGNKAVRLPLMEcvqLTKDVQKAMDEKRFDEAAALR 362
|
|
| Eukaryotic_PFK |
cd00764 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
78-371 |
1.75e-43 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.
Pssm-ID: 238389 [Multi-domain] Cd Length: 762 Bit Score: 169.23 E-value: 1.75e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 78 GGMNAAVRAVTRMGIYVGAKVFLIYEGYEGLVEGGenIKQANWLSVSNIIQLGGTIIGSARCkafTTREGRRAAAYNLVQ 157
Cdd:cd00764 402 AGMNAAVRSAVRYGLAHGHRPYAIYDGFEGLAKGQ--IVELGWIDVGGWTGRGGSELGTKRT---LPKKDLETIAYNFQK 476
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 158 HGITNLCVIGGDGSLTGanifrsewgsLLEELVAEGKisettartYSHLNIAGLV--GSIDNDFCGTDMTIGTDSALHRI 235
Cdd:cd00764 477 YGIDGLIIVGGFEAYKG----------LLQLREAREQ--------YEEFCIPMVLipATVSNNVPGTDFSLGSDTALNAL 538
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 236 MEVIDAITTTAQS-HQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAP--PEDGWENF--MCERLGETRSRGSRLNII 310
Cdd:cd00764 539 MKYCDRIKQSASGtKRRVFIVETMGGYCGYLATMTGLAVGADAAYVFEEPfnIRDLQENVehLTEKMKTTIGRGLVLRNE 618
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 590122057 311 IIAEGAIDRNGKPISSSYVKDLvvqrlgFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEAV 371
Cdd:cd00764 619 KCNENYTTVFTYELYSEEGKGV------FDCRTNVLGHVQQGGAPSPFDRNFGTKFAVKAM 673
|
|
| PRK14071 |
PRK14071 |
ATP-dependent 6-phosphofructokinase; |
454-732 |
1.42e-30 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 184487 [Multi-domain] Cd Length: 360 Bit Score: 124.03 E-value: 1.42e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 454 ILNVGAPAAGMNAAVRSAVRTGISH-GHTVYVVHDGFEGLAKG--QVQEVGWHDVAGWLGRGGSMLGTKRT-------LP 523
Cdd:PRK14071 9 ILTSGGDCAGLNAVIRAVVHRARGTyGWEVIGIRDATQGLMARppQYIELDLDQVDDLLRMGGTILGTTNKgdpfafpMP 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 524 KGQL----ESIVENIRIYGIHALLVVGGfeayEGVLQLVEargryeELC----IVMCVIPATISNNVPGTDFSLGSDTAV 595
Cdd:PRK14071 89 DGSLrdrsQEIIDGYHSLGLDALIGIGG----DGSLAILR------RLAqqggINLVGIPKTIDNDVGATEVSIGFDTAV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 596 NAAMESCDRIKQSASgTKRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFNIhdlkvnvEHMTEKMKTDIQRG--- 672
Cdd:PRK14071 159 NIATEALDRLHFTAA-SHNRVMILEVMGRDAGHIALAAGIAGGADVILIPEIPYTL-------ENVCKKIRERQEEGknf 230
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 590122057 673 -LVLRNEKCHDY------YTTEFLYNLYSSEGKGVFD---------CRTNVLGHLQQGGAPTPFDRNYGTKLGVKA 732
Cdd:PRK14071 231 cLVVVSEAVRTEegeqvtKTQALGEDRYGGIGQYLAEqiaertgaeTRVTVLGHIQRGGIPSPRDRLLASAFGVAA 306
|
|
| PTZ00286 |
PTZ00286 |
6-phospho-1-fructokinase; Provisional |
79-316 |
1.93e-24 |
|
6-phospho-1-fructokinase; Provisional
Pssm-ID: 185539 Cd Length: 459 Bit Score: 107.44 E-value: 1.93e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 79 GMNAAVRAVTRMGIYV-GAK-VFLIYEGYEGLVEggENIKQANWLSVSNIIQLGGTIIGSARcKAFTTREgrraAAYNLV 156
Cdd:PTZ00286 101 GLNVVIRELVMNLINNyGVKtIYGAKYGYKGLYK--EDWIKLDPKDVKTIHRLGGTILGSSR-GGFDPKV----MVDTLI 173
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 157 QHGITNLCVIGGDGSLTGANifrsewgSLLEELVAEG-KISettartyshlnIAGLVGSIDNDFCGTDMTIGTDSALHRI 235
Cdd:PTZ00286 174 RHGINILFTLGGDGTHRGAL-------AIYKELRRRKlNIS-----------VVGIPKTIDNDIPIIDESFGFQTAVEEA 235
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 236 MEVIDAITTTAQSHQRTF-VLEVMGRHCGYLALVSALASG-ADWLFIPEAP-PEDGWENFMCERLGETRSRgsrlnIIII 312
Cdd:PTZ00286 236 QNAIRAAYVEAKSAKNGVgIVKLMGRDSGFIALHASVASAdVNVCLIPEFDiPLEGVLEYIEQRLQKKGHC-----VIVV 310
|
....
gi 590122057 313 AEGA 316
Cdd:PTZ00286 311 AEGA 314
|
|
| PTZ00286 |
PTZ00286 |
6-phospho-1-fructokinase; Provisional |
444-651 |
5.89e-18 |
|
6-phospho-1-fructokinase; Provisional
Pssm-ID: 185539 Cd Length: 459 Bit Score: 87.41 E-value: 5.89e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 444 PKEKSNFS-----LAILNVGAPAAGMNAAVRSAVRTGIS--HGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSML 516
Cdd:PTZ00286 77 PRKHLYFNpkevkAGIVTCGGLCPGLNVVIRELVMNLINnyGVKTIYGAKYGYKGLYKEDWIKLDPKDVKTIHRLGGTIL 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 517 GTKRTlpkGQ-LESIVENIRIYGIHALLVVGGFEAYEGVLQL-VEARGRYEELCIvmCVIPATISNNVPGTDFSLGSDTA 594
Cdd:PTZ00286 157 GSSRG---GFdPKVMVDTLIRHGINILFTLGGDGTHRGALAIyKELRRRKLNISV--VGIPKTIDNDIPIIDESFGFQTA 231
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 590122057 595 VNAAMESCDRIKQSASGTKRRVFIVETMGGYCGYLATVTGIAVG-ADAAYVFEDPFNI 651
Cdd:PTZ00286 232 VEEAQNAIRAAYVEAKSAKNGVGIVKLMGRDSGFIALHASVASAdVNVCLIPEFDIPL 289
|
|
| PRK06830 |
PRK06830 |
ATP-dependent 6-phosphofructokinase; |
79-316 |
1.31e-17 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 235869 Cd Length: 443 Bit Score: 86.46 E-value: 1.31e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 79 GMNAAVRAVTR--MGIYVGAKVFLIYEGYEGLV-EGGENIKQANWLSVSNIIQLGGTIIGSARckafttreGRRAAAY-- 153
Cdd:PRK06830 94 GLNDVIRAIVLelHHHYGVRRILGIRYGYQGLIpRYGHDPVELTPEVVADIHEFGGTILGSSR--------GPQDPEEiv 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 154 -NLVQHGITNLCVIGGDGSLTGANifrsewgslleelvaegKISETTARTYSHLNIAGLVGSIDNDFCGTDMTIGTDSAL 232
Cdd:PRK06830 166 dTLERMNINILFVIGGDGTLRGAS-----------------AIAEEIERRGLKISVIGIPKTIDNDINFIQKSFGFETAV 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 233 HRIMEVIDAITTTAQSHQRTFVL-EVMGRHCGYLALVSALASG-ADWLFIPEAPPE-DGWENFMcERLgETRSRGSRLNI 309
Cdd:PRK06830 229 EKATEAIRCAHVEANGAPNGIGLvKLMGRHSGFIAAYAALASKdVNFVLIPEVPFDlEGPNGLL-AAL-EKRLAERGHAV 306
|
....*..
gi 590122057 310 IIIAEGA 316
Cdd:PRK06830 307 IVVAEGA 313
|
|
| PLN02564 |
PLN02564 |
6-phosphofructokinase |
97-316 |
3.75e-15 |
|
6-phosphofructokinase
Pssm-ID: 178178 Cd Length: 484 Bit Score: 79.02 E-value: 3.75e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 97 KVFLIYEGYEGLVegGENIKQANWLSVSNIIQLGGTIIGSARCKAFTTRegrraAAYNLVQHGITNLCVIGGDGSLTGAN 176
Cdd:PLN02564 121 RILGIDGGYRGFY--SRNTIPLTPKVVNDIHKRGGTILGTSRGGHDTSK-----IVDSIQDRGINQVYIIGGDGTQKGAS 193
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 177 ifrsewgSLLEELVAEG-KISettartyshlnIAGLVGSIDNDFCGTDMTIGTDSALHRIMEVIDAITTTAQS-HQRTFV 254
Cdd:PLN02564 194 -------VIYEEIRRRGlKVA-----------VAGIPKTIDNDIPVIDKSFGFDTAVEEAQRAINAAHVEAESvENGIGL 255
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 590122057 255 LEVMGRHCGYLALVSALAS-GADWLFIPEAP----PEDGWENFMCERLGETRSRgsrlnIIIIAEGA 316
Cdd:PLN02564 256 VKLMGRYSGFIAMYATLASrDVDCCLIPESPfyleGKGGLFEFIEKRLKENGHM-----VIVVAEGA 317
|
|
| PRK14072 |
PRK14072 |
diphosphate--fructose-6-phosphate 1-phosphotransferase; |
215-382 |
6.71e-15 |
|
diphosphate--fructose-6-phosphate 1-phosphotransferase;
Pssm-ID: 237600 [Multi-domain] Cd Length: 416 Bit Score: 77.59 E-value: 6.71e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 215 IDNDFCGTDMTIGTDSALHRI----MEV-IDAITTTAQShqRTFVLEVMGRHCGYLALVSALAS-----GADWLFIPEAP 284
Cdd:PRK14072 142 IDNDLPGTDHCPGFGSAAKYIatsvLEAaLDVAAMANTS--KVFILEVMGRHAGWLAAAAALAKqnpddAPHLIYLPERP 219
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 285 PEDgwENFMcERLGETRSRGSRLnIIIIAEGAIDRNGKPISSS-----------------YVKDLVVQRLGFDTRVTVLG 347
Cdd:PRK14072 220 FDE--EKFL-ADVRAIVKRYGYC-VVVVSEGIRDADGKFIAEAglaedafghaqlggvapVLANLIKEKLGKKVHWAVLD 295
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 590122057 348 HVQR--GGTPSAFDR---ILSSKM-------GMEAVMALLEATPDTP 382
Cdd:PRK14072 296 YLQRaaRHIASKTDVeeaYAVGKAaveyalaGKNGVMPAIRRTSDDP 342
|
|
| PLN02884 |
PLN02884 |
6-phosphofructokinase |
79-408 |
1.32e-12 |
|
6-phosphofructokinase
Pssm-ID: 178472 [Multi-domain] Cd Length: 411 Bit Score: 70.61 E-value: 1.32e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 79 GMNAAVRA-VTRMGIYVGAKVFLIYEGYEGLVEggENIKQANwLS---VSNIIQLGGTIIGSARCKAFTTRegrraAAYN 154
Cdd:PLN02884 67 GLNDVIRQiVFTLEIYGVKNIVGIPFGYRGFFE--KGLSEMP-LSrkvVQNIHLSGGSLLGVSRGGAKTSD-----IVDS 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 155 LVQHGITNLCVIGGDGSLTGANIfrsewgslleelvaegkISETTARTYSHLNIAGLVGSIDNDFCGTDMTIGTDSALHR 234
Cdd:PLN02884 139 IEARGINMLFVLGGNGTHAGANA-----------------IHNECRKRKMKVSVVGVPKTIDNDILLMDKTFGFDTAVEE 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 235 IMEVIDAITTTAQSHQRTF-VLEVMGRHCGYLALVSALASG-ADWLFIPEAPPE-DGWENFM--CERLGETRSRGsrlnI 309
Cdd:PLN02884 202 AQRAINSAYIEAHSAYHGIgLVKLMGRSSGFIAMHASLASGqVDICLIPEVPFTlDGPNGVLrhLEHLIETKGSA----V 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 310 IIIAEGA-IDRNGKPISSSYVKDLVVQRLGFDTRVTVLGHVQRGGTPS-----------------AFDRILSSKMGMEAV 371
Cdd:PLN02884 278 VCVAEGAgQDLLQKTNATDASGNPVLGDIGVHLQQEIKKHFKDIGVPAdvkyidptymiracranASDAILCTVLGQNAV 357
|
330 340 350
....*....|....*....|....*....|....*..
gi 590122057 372 MAlleATPDTPACVVTLSGNQSVRLPLMECVQMTKEV 408
Cdd:PLN02884 358 HG---AFAGFSGITVGICNTHYVYLPIPEVIAYPRRV 391
|
|
| PLN02884 |
PLN02884 |
6-phosphofructokinase |
440-664 |
1.25e-11 |
|
6-phosphofructokinase
Pssm-ID: 178472 [Multi-domain] Cd Length: 411 Bit Score: 67.53 E-value: 1.25e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 440 HQKPPKEKSNF-----SLAILNVGAPAAGMNAAVRSAVRT----------GISHGHTvyvvhdGF--EGLA-----KGQV 497
Cdd:PLN02884 39 HRAGPRKKIYFepeevKAAIVTCGGLCPGLNDVIRQIVFTleiygvknivGIPFGYR------GFfeKGLSemplsRKVV 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 498 QEVGWHdvagwlgrGGSMLGTKRTLPKgqLESIVENIRIYGIHALLVVGGFEAYEGVLQL-VEARGRYEELCIVmCViPA 576
Cdd:PLN02884 113 QNIHLS--------GGSLLGVSRGGAK--TSDIVDSIEARGINMLFVLGGNGTHAGANAIhNECRKRKMKVSVV-GV-PK 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 577 TISNNVPGTDFSLGSDTAVNAAMESCDRIKQSASGTKRRVFIVETMGGYCGYLATVTGIAVG-ADAAYVFEDPFNIH--- 652
Cdd:PLN02884 181 TIDNDILLMDKTFGFDTAVEEAQRAINSAYIEAHSAYHGIGLVKLMGRSSGFIAMHASLASGqVDICLIPEVPFTLDgpn 260
|
250
....*....|..
gi 590122057 653 DLKVNVEHMTEK 664
Cdd:PLN02884 261 GVLRHLEHLIET 272
|
|
| PRK06830 |
PRK06830 |
ATP-dependent 6-phosphofructokinase; |
463-652 |
2.25e-10 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 235869 Cd Length: 443 Bit Score: 63.73 E-value: 2.25e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 463 GMNAAVRSAVRTGishgHTVYVVHD------GFEGLakgqVQEVGwHD--------VAGWLGRGGSMLGTKRtlpkGQ-- 526
Cdd:PRK06830 94 GLNDVIRAIVLEL----HHHYGVRRilgiryGYQGL----IPRYG-HDpveltpevVADIHEFGGTILGSSR----GPqd 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 527 LESIVENIRIYGIHALLVVGGFEAYEGVLQLV-EARGRYEELCIVmcVIPATISNNVPGTDFSLGSDTAVNAAMESCDRI 605
Cdd:PRK06830 161 PEEIVDTLERMNINILFVIGGDGTLRGASAIAeEIERRGLKISVI--GIPKTIDNDINFIQKSFGFETAVEKATEAIRCA 238
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 590122057 606 KQSASGTKRRVFIVETMGGYCGYLATVTGIAVgADAAYVF--EDPFNIH 652
Cdd:PRK06830 239 HVEANGAPNGIGLVKLMGRHSGFIAAYAALAS-KDVNFVLipEVPFDLE 286
|
|
| PLN02564 |
PLN02564 |
6-phosphofructokinase |
511-649 |
1.00e-09 |
|
6-phosphofructokinase
Pssm-ID: 178178 Cd Length: 484 Bit Score: 61.69 E-value: 1.00e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 511 RGGSMLGTKRtlpKGQ-LESIVENIRIYGIHALLVVGGFEAYEG---VLQLVEARGryeeLCIVMCVIPATISNNVPGTD 586
Cdd:PLN02564 151 RGGTILGTSR---GGHdTSKIVDSIQDRGINQVYIIGGDGTQKGasvIYEEIRRRG----LKVAVAGIPKTIDNDIPVID 223
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 590122057 587 FSLGSDTAVNAAMESCDRIKQSASGTKRRVFIVETMGGYCGYLATVTGIAV-GADAAYVFEDPF 649
Cdd:PLN02564 224 KSFGFDTAVEEAQRAINAAHVEAESVENGIGLVKLMGRYSGFIAMYATLASrDVDCCLIPESPF 287
|
|
| PRK06555 |
PRK06555 |
pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated |
104-316 |
8.87e-08 |
|
pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated
Pssm-ID: 180620 [Multi-domain] Cd Length: 403 Bit Score: 55.40 E-value: 8.87e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 104 GYEGLVeGGENI-------KQANWLSvsniiQLGGTIIGSARCKAFTT---------REGR---RAAAYNLVQHGITNLC 164
Cdd:PRK06555 44 GYQGLL-LGDSIeitpavrANAGLLH-----RYGGSPIGNSRVKLTNVadcvkrglvKEGEnplKVAAERLAADGVDILH 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 165 VIGGDGSLTGAnifrsewGSLLEELVAEGkisettartYsHLNIAGLVGSIDNDFCGTDMTIGTDSALHRIMEVIDAITT 244
Cdd:PRK06555 118 TIGGDDTNTTA-------ADLAAYLAENG---------Y-DLTVVGLPKTIDNDVVPIRQSLGAWTAAEQGARFFDNVIN 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 245 TAQSHQRTFVL-EVMGRHCGYLALVSALA-----SGADWL---------------FIPEAPPEDGWEnfmCERLGETRSR 303
Cdd:PRK06555 181 EHSANPRMLIIhEVMGRNCGWLTAATARAyrewlDRQEYVpgfglsaerwdihavYLPEMAFDLEAE---AERLKAVMDE 257
|
250
....*....|...
gi 590122057 304 GSRLNiIIIAEGA 316
Cdd:PRK06555 258 VGNVN-IFLSEGA 269
|
|
| PRK14072 |
PRK14072 |
diphosphate--fructose-6-phosphate 1-phosphotransferase; |
458-716 |
5.58e-07 |
|
diphosphate--fructose-6-phosphate 1-phosphotransferase;
Pssm-ID: 237600 [Multi-domain] Cd Length: 416 Bit Score: 52.94 E-value: 5.58e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 458 GAPAAGMNAAVRSAVRTGISHG--HTVYVVHDGFEGLAKGQV---QEVGWHDVAGWLGRGGSMLGTKRTLPKG------Q 526
Cdd:PRK14072 12 GGPTAVINASAAGVIEEARKHKkiGKVYGARNGIIGILDEDLidlSKESDEALAALAHTPSGALGSCRYKLKSleedraE 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 527 LESIVENIRIYGIHALLVVGG---FEAYEGVLQLVEARGrYEELCIVmcvIPATISNNVPGTDFSLGSDTAVN----AAM 599
Cdd:PRK14072 92 YERLLEVFKAHDIGYFFYNGGndsMDTALKVSQLAKKMG-YPIRCIG---IPKTIDNDLPGTDHCPGFGSAAKyiatSVL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 600 E-SCDrikQSASGTKRRVFIVETMGGYCGYLATVTGIA-----VGADAAYVFEDPFnihdlkvNVEHMTEKMKTDIQRG- 672
Cdd:PRK14072 168 EaALD---VAAMANTSKVFILEVMGRHAGWLAAAAALAkqnpdDAPHLIYLPERPF-------DEEKFLADVRAIVKRYg 237
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 590122057 673 --LVLRNEKCHDyytteflynlysSEGKGVFD--CRTNVLGHLQQGGA 716
Cdd:PRK14072 238 ycVVVVSEGIRD------------ADGKFIAEagLAEDAFGHAQLGGV 273
|
|
| PTZ00287 |
PTZ00287 |
6-phosphofructokinase; Provisional |
68-318 |
1.31e-05 |
|
6-phosphofructokinase; Provisional
Pssm-ID: 240345 [Multi-domain] Cd Length: 1419 Bit Score: 49.27 E-value: 1.31e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 68 PGGTSIMSrlggmnaavravtrmGIYVGAKVFLIYEGYEGLVEGGENIKQANWLSVSNII-----QLGG-TIIGSARCKa 141
Cdd:PTZ00287 190 PGGHNVIS---------------GIYDYAKRYNEQSQVIGFLGGIDGLYSKNYVTITDSLmnrfrNLGGfNMLWSGRGK- 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 142 fTTREGRRAAAYNLVQH-GITNLCVIGGDGSLTGAnifrsewgSLLEELVAEGKISettartyshLNIAGLVGSIDNDFC 220
Cdd:PTZ00287 254 -VRNKDDLIAIENIVAKlKLNGLVIIGGDGSNSNA--------ALISEYFAERQIP---------ISIIGIPKTIDGDLK 315
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 221 --GTDMTIGTDSALHRIMEVIDAITTTAQS-HQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEDGWE------- 290
Cdd:PTZ00287 316 seAIEISFGFDTATKTYSEVIGNLCTDVKTgHNVYHVVRVMGRSASHVVLECALQTRPNIVLIGEEVEKENLSlkdivsn 395
|
250 260 270
....*....|....*....|....*....|
gi 590122057 291 --NFMCERlgetRSRGSRLNIIIIAEGAID 318
Cdd:PTZ00287 396 ivNTILKR----RSLNKNYGVILIPEGLIE 421
|
|
| PTZ00468 |
PTZ00468 |
phosphofructokinase family protein; Provisional |
123-318 |
3.59e-04 |
|
phosphofructokinase family protein; Provisional
Pssm-ID: 185647 [Multi-domain] Cd Length: 1328 Bit Score: 44.19 E-value: 3.59e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 123 VSNIIQLGG-TIIGSARCKaFTTREGRRAAAYNLVQHGITNLCVIGGDGSLTGANIfrsewgslleelvaegkISETTAR 201
Cdd:PTZ00468 160 INGILNQGGfNIICSGRHK-IETEEQMRASLEICEKLKLHGLVVIGGDDSNTNAAV-----------------LAEYFKR 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122057 202 TYSHLNIAGLVGSIDNDFCG--TDMTIGTDSALHRIMEVIDAITTTAQSHQ-RTFVLEVMGRHCGYLALVSALASGADWL 278
Cdd:PTZ00468 222 NSSSTVVVGCPKTIDGDLKNevIETSFGYDTAVKTYSEQIGSIMDAIKTEGyGYYFVRLMGRSASHITLECGLQTRANMI 301
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 590122057 279 FIPEAPPEDGWE-----NFMCERLGETRSRGSRLNIIIIAEGAID 318
Cdd:PTZ00468 302 LIGEEIKEENRSlmsivDEIVEMILKRDSLGKKHGIVLLPEGLIE 346
|
|
| |
