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Conserved domains on  [gi|56090620|ref|NP_001007532|]
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NKAP-like protein [Homo sapiens]

Protein Classification

NKAP family protein( domain architecture ID 10532744)

NKAP (NF-kappa-B-activating protein) family protein, similar to human NKAP-like protein (NKAPL) that functions as a transcriptional repressor of Notch-mediated signaling

Gene Ontology:  GO:0003682|GO:0003676

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Nkap_C pfam06047
NF-kappa-B-activating protein C-terminal domain; This is the C-terminal domain found in ...
 293-394 1.33e-57

NF-kappa-B-activating protein C-terminal domain; This is the C-terminal domain found in NF-kappa-B-activating protein (Nkap) and a hypothetical open reading frame on chromosome 6, c6orf194. Functional studies in Nkap indicate that this domain is the HDAC3 binding domain and is required for transcriptional repression. Nkap functions as a transcriptional repressor on Notch target genes, and is required for T cell development and acquisition of functional competency.


:

Pssm-ID: 461812  Cd Length: 102  Bit Score: 183.61  E-value: 1.33e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56090620   293 PLKYGHALLPGEGAAMAEYVKAGKRIPRRGEIGLTSEEIGSFECSGYVMSGSRHRRMEAVRLRKENQIYSADEKRALASF 372
Cdd:pfam06047   1 ERNYGGALLPGEGAAMAQYVQEGKRIPRRGEIGLTSEEIEKFEDLGYVMSGSRHRRMNAVRIRKENQVYSAEEKRALALL 80

                          90       100
                  ....*....|....*....|..
gi 56090620   373 NQEERRKRESKILASFREMVHK 394
Cdd:pfam06047  81 NKEERAKRENEIISQFRELVDE 102
 
Name Accession Description Interval E-value
Nkap_C pfam06047
NF-kappa-B-activating protein C-terminal domain; This is the C-terminal domain found in ...
 293-394 1.33e-57

NF-kappa-B-activating protein C-terminal domain; This is the C-terminal domain found in NF-kappa-B-activating protein (Nkap) and a hypothetical open reading frame on chromosome 6, c6orf194. Functional studies in Nkap indicate that this domain is the HDAC3 binding domain and is required for transcriptional repression. Nkap functions as a transcriptional repressor on Notch target genes, and is required for T cell development and acquisition of functional competency.


Pssm-ID: 461812  Cd Length: 102  Bit Score: 183.61  E-value: 1.33e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56090620   293 PLKYGHALLPGEGAAMAEYVKAGKRIPRRGEIGLTSEEIGSFECSGYVMSGSRHRRMEAVRLRKENQIYSADEKRALASF 372
Cdd:pfam06047   1 ERNYGGALLPGEGAAMAQYVQEGKRIPRRGEIGLTSEEIEKFEDLGYVMSGSRHRRMNAVRIRKENQVYSAEEKRALALL 80

                          90       100
                  ....*....|....*....|..
gi 56090620   373 NQEERRKRESKILASFREMVHK 394
Cdd:pfam06047  81 NKEERAKRENEIISQFRELVDE 102
 
Name Accession Description Interval E-value
Nkap_C pfam06047
NF-kappa-B-activating protein C-terminal domain; This is the C-terminal domain found in ...
 293-394 1.33e-57

NF-kappa-B-activating protein C-terminal domain; This is the C-terminal domain found in NF-kappa-B-activating protein (Nkap) and a hypothetical open reading frame on chromosome 6, c6orf194. Functional studies in Nkap indicate that this domain is the HDAC3 binding domain and is required for transcriptional repression. Nkap functions as a transcriptional repressor on Notch target genes, and is required for T cell development and acquisition of functional competency.


Pssm-ID: 461812  Cd Length: 102  Bit Score: 183.61  E-value: 1.33e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56090620   293 PLKYGHALLPGEGAAMAEYVKAGKRIPRRGEIGLTSEEIGSFECSGYVMSGSRHRRMEAVRLRKENQIYSADEKRALASF 372
Cdd:pfam06047   1 ERNYGGALLPGEGAAMAQYVQEGKRIPRRGEIGLTSEEIEKFEDLGYVMSGSRHRRMNAVRIRKENQVYSAEEKRALALL 80

                          90       100
                  ....*....|....*....|..
gi 56090620   373 NQEERRKRESKILASFREMVHK 394
Cdd:pfam06047  81 NKEERAKRENEIISQFRELVDE 102
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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