protein lifeguard 3 [Rattus norvegicus]
Protein Classification
protein lifeguard( domain architecture ID 10179627)
protein lifeguard similar to human protein lifeguard 2, an antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis, and regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||
| LFG_like | cd10428 | Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; ... |
87-306 | 1.84e-109 | ||||
Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; Lifeguard (LFG) inhibits Fas-mediated apoptosis and interacts with the death receptor FasR/CD95/Apo1. LFG has been shown to interact with Bax and is supposed to be integral to cellular membranes such as the ER. A close homolog, PP1201 or RECS1, appears located in the Golgi compartment and also interacts with the Fas receptor CD95/Apo1. PP1201 is expressed in response to shear stress. : Pssm-ID: 198410 Cd Length: 217 Bit Score: 316.79 E-value: 1.84e-109
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| Name | Accession | Description | Interval | E-value | |||||
| LFG_like | cd10428 | Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; ... |
87-306 | 1.84e-109 | |||||
Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; Lifeguard (LFG) inhibits Fas-mediated apoptosis and interacts with the death receptor FasR/CD95/Apo1. LFG has been shown to interact with Bax and is supposed to be integral to cellular membranes such as the ER. A close homolog, PP1201 or RECS1, appears located in the Golgi compartment and also interacts with the Fas receptor CD95/Apo1. PP1201 is expressed in response to shear stress. Pssm-ID: 198410 Cd Length: 217 Bit Score: 316.79 E-value: 1.84e-109
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| Bax1-I | pfam01027 | Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family ... |
94-304 | 2.05e-30 | |||||
Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localized to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localize predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress. BI-1 appears to exert its effect through an interaction with calmodulin. The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner. Examination of the crystal structure of a bacterial member of this family shows that these proteins mediate a calcium leak across the membrane that is pH-dependent. Calcium homoeostasis balances passive calcium leak with active calcium uptake. The structure exists in a pore-closed and pore-open conformation, at pHs of 8 and 6 respectively, and the pore can be opened by intracrystalline transition; together these findings suggest that pH controls the conformational transition. Pssm-ID: 460029 Cd Length: 207 Bit Score: 113.81 E-value: 2.05e-30
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| YbhL | COG0670 | Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family ... |
65-309 | 6.41e-22 | |||||
Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family [Inorganic ion transport and metabolism]; Pssm-ID: 440434 Cd Length: 231 Bit Score: 91.78 E-value: 6.41e-22
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| Name | Accession | Description | Interval | E-value | |||||
| LFG_like | cd10428 | Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; ... |
87-306 | 1.84e-109 | |||||
Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; Lifeguard (LFG) inhibits Fas-mediated apoptosis and interacts with the death receptor FasR/CD95/Apo1. LFG has been shown to interact with Bax and is supposed to be integral to cellular membranes such as the ER. A close homolog, PP1201 or RECS1, appears located in the Golgi compartment and also interacts with the Fas receptor CD95/Apo1. PP1201 is expressed in response to shear stress. Pssm-ID: 198410 Cd Length: 217 Bit Score: 316.79 E-value: 1.84e-109
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| GAAP_like | cd10429 | Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a ... |
89-309 | 2.32e-46 | |||||
Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a regulator of apoptosis that is related to the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Human GAAP has been linked to the modulation of intracellular fluxes of Ca(2+), by suppressing influx from the extracellular medium and reducing release from intracellular stores. A viral homolog (vaccinia virus vGAAP) acts similar to its human counterpart in inhibiting apoptosis. Pssm-ID: 198411 Cd Length: 233 Bit Score: 156.22 E-value: 2.32e-46
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| BI-1-like | cd06181 | BAX inhibitor (BI)-1/YccA-like protein family; Mammalian members of the BAX inhibitor (BI)-1 ... |
92-306 | 3.91e-41 | |||||
BAX inhibitor (BI)-1/YccA-like protein family; Mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Their broad tissue distribution and high degree of conservation suggests an important regulatory role. This superfamily also contains the lifeguard(LFG)-like proteins and other subfamilies which appear to be related by common descent and also function as inhibitors of apoptosis. In plants, BI-1 like proteins play a role in pathogen resistance. A prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes. Pssm-ID: 198409 Cd Length: 202 Bit Score: 141.78 E-value: 3.91e-41
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| Bax1-I | pfam01027 | Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family ... |
94-304 | 2.05e-30 | |||||
Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localized to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localize predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress. BI-1 appears to exert its effect through an interaction with calmodulin. The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner. Examination of the crystal structure of a bacterial member of this family shows that these proteins mediate a calcium leak across the membrane that is pH-dependent. Calcium homoeostasis balances passive calcium leak with active calcium uptake. The structure exists in a pore-closed and pore-open conformation, at pHs of 8 and 6 respectively, and the pore can be opened by intracrystalline transition; together these findings suggest that pH controls the conformational transition. Pssm-ID: 460029 Cd Length: 207 Bit Score: 113.81 E-value: 2.05e-30
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| YbhL | COG0670 | Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family ... |
65-309 | 6.41e-22 | |||||
Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family [Inorganic ion transport and metabolism]; Pssm-ID: 440434 Cd Length: 231 Bit Score: 91.78 E-value: 6.41e-22
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| BI-1-like_bacterial | cd10432 | Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial ... |
93-306 | 2.92e-17 | |||||
Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial relatives of the mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. In plants, BI-1 like proteins play a role in pathogen resistance. A characterized prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes. Pssm-ID: 198414 Cd Length: 211 Bit Score: 78.76 E-value: 2.92e-17
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| YccA_like | cd10433 | YccA-like proteins; A prokaryotic member of the BAX inhibitor (BI)-1 like family of small ... |
136-306 | 3.42e-09 | |||||
YccA-like proteins; A prokaryotic member of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes. Pssm-ID: 198415 Cd Length: 205 Bit Score: 55.67 E-value: 3.42e-09
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| BI-1 | cd10430 | BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small ... |
233-304 | 1.62e-03 | |||||
BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Their broad tissue distribution and high degree of conservation suggests an important regulatory role. In plants, BI-1 like proteins play a role in pathogen resistance. Pssm-ID: 198412 Cd Length: 213 Bit Score: 39.13 E-value: 1.62e-03
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| GHITM | cd10431 | Growth-hormone inducible transmembrane protein; GHITM appears to be ubiquitiously expressed in ... |
250-307 | 8.31e-03 | |||||
Growth-hormone inducible transmembrane protein; GHITM appears to be ubiquitiously expressed in mammalian cells and expression has also been observed in various cancer cell lines. A cytoprotective function has been suggested. It is closely related to the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect. Pssm-ID: 198413 Cd Length: 264 Bit Score: 37.36 E-value: 8.31e-03
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