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Conserved domains on  [gi|164663893|ref|NP_001011976|]
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WD repeat-containing protein 31 [Rattus norvegicus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
48-354 2.73e-47

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 165.47  E-value: 2.73e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663893  48 RVQTKASQEYIPAHVDTVSVVA-ALNSDLCISGGKDKTAVVYNWKTGHVVRRFIGHEREITKIACIPKSNQFFSASRDKT 126
Cdd:COG2319  106 DLATGLLLRTLTGHTGAVRSVAfSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGT 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663893 127 VLMWDLQgSSQPRQQLSGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWDVGTGQCVERASVSRNLVTHLCWVPREPYIVQT 206
Cdd:COG2319  186 VRLWDLA-TGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASG 264

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663893 207 SEDKTIRLWDCRGLQMAHVFPTKQHIQTHCEVSVDGHTCVScssgfGGEGCEATLWDLrQTRERMCEYKGHFQTVASCVF 286
Cdd:COG2319  265 SADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLAS-----GSDDGTVRLWDL-ATGKLLRTLTGHTGAVRSVAF 338

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 164663893 287 LPKSAalmpMIATSAHDSKVKIWNQDTGACLSTLSlDGSGPLTSLAV-GDITSLLCASFYRGVHLLRMD 354
Cdd:COG2319  339 SPDGK----TLASGSDDGTVRLWDLATGELLRTLT-GHTGAVTSVAFsPDGRTLASGSADGTVRLWDLA 402
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
48-354 2.73e-47

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 165.47  E-value: 2.73e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663893  48 RVQTKASQEYIPAHVDTVSVVA-ALNSDLCISGGKDKTAVVYNWKTGHVVRRFIGHEREITKIACIPKSNQFFSASRDKT 126
Cdd:COG2319  106 DLATGLLLRTLTGHTGAVRSVAfSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGT 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663893 127 VLMWDLQgSSQPRQQLSGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWDVGTGQCVERASVSRNLVTHLCWVPREPYIVQT 206
Cdd:COG2319  186 VRLWDLA-TGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASG 264

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663893 207 SEDKTIRLWDCRGLQMAHVFPTKQHIQTHCEVSVDGHTCVScssgfGGEGCEATLWDLrQTRERMCEYKGHFQTVASCVF 286
Cdd:COG2319  265 SADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLAS-----GSDDGTVRLWDL-ATGKLLRTLTGHTGAVRSVAF 338

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 164663893 287 LPKSAalmpMIATSAHDSKVKIWNQDTGACLSTLSlDGSGPLTSLAV-GDITSLLCASFYRGVHLLRMD 354
Cdd:COG2319  339 SPDGK----TLASGSDDGTVRLWDLATGELLRTLT-GHTGAVTSVAFsPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 58-344 2.47e-45

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 157.11  E-value: 2.47e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663893  58 IPAHVDTVSVVAAL-NSDLCISGGKDKTAVVYNWKTGHVVRRFIGHEREITKIACIPKSNQFFSASRDKTVLMWDLQgSS 136
Cdd:cd00200    5 LKGHTGGVTCVAFSpDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE-TG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663893 137 QPRQQLSGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWDVGTGQCVERASVSRNLVTHLCWVPREPYIVQTSEDKTIRLWD 216
Cdd:cd00200   84 ECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWD 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663893 217 CRGLQMAHVFPTKQHIQTHCEVSVDGHTCVSCSSgfggeGCEATLWDLRQTRErMCEYKGHFQTVASCVFLPKSAalmpM 296
Cdd:cd00200  164 LRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSS-----DGTIKLWDLSTGKC-LGTLRGHENGVNSVAFSPDGY----L 233

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 164663893 297 IATSAHDSKVKIWNQDTGACLSTLSLdGSGPLTSLAV-GDITSLLCASF 344
Cdd:cd00200  234 LASGSEDGTIRVWDLRTGECVQTLSG-HTNSVTSLAWsPDGKRLASGSA 281
PTZ00421 PTZ00421
coronin; Provisional
 100-218 6.27e-07

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 51.05  E-value: 6.27e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663893 100 IGHEREITKIACIPKSNQ-FFSASRDKTVLMWDL------QGSSQPRQQLSGHAMVVTGLAVSPDSSQ-LCTGSRDNSLL 171
Cdd:PTZ00421  72 LGQEGPIIDVAFNPFDPQkLFTASEDGTIMGWGIpeegltQNISDPIVHLQGHTKKVGIVSFHPSAMNvLASAGADMVVN 151

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 164663893 172 LWDVGTGQCVERASVSRNLVTHLCWVPREPYIVQTSEDKTIRLWDCR 218
Cdd:PTZ00421 152 VWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPR 198
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 135-174 6.72e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 6.72e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 164663893   135 SSQPRQQLSGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWD 174
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
136-174 6.58e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 6.58e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 164663893  136 SQPRQQLSGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWD 174
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
48-354 2.73e-47

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 165.47  E-value: 2.73e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663893  48 RVQTKASQEYIPAHVDTVSVVA-ALNSDLCISGGKDKTAVVYNWKTGHVVRRFIGHEREITKIACIPKSNQFFSASRDKT 126
Cdd:COG2319  106 DLATGLLLRTLTGHTGAVRSVAfSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGT 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663893 127 VLMWDLQgSSQPRQQLSGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWDVGTGQCVERASVSRNLVTHLCWVPREPYIVQT 206
Cdd:COG2319  186 VRLWDLA-TGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASG 264

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663893 207 SEDKTIRLWDCRGLQMAHVFPTKQHIQTHCEVSVDGHTCVScssgfGGEGCEATLWDLrQTRERMCEYKGHFQTVASCVF 286
Cdd:COG2319  265 SADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLAS-----GSDDGTVRLWDL-ATGKLLRTLTGHTGAVRSVAF 338

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 164663893 287 LPKSAalmpMIATSAHDSKVKIWNQDTGACLSTLSlDGSGPLTSLAV-GDITSLLCASFYRGVHLLRMD 354
Cdd:COG2319  339 SPDGK----TLASGSDDGTVRLWDLATGELLRTLT-GHTGAVTSVAFsPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
48-333 1.38e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 163.54  E-value: 1.38e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663893  48 RVQTKASQEYIPAHVDTVSVVAALNSDLCISGGKDKTAVVYNWKTGHVVRRFIGHEREITKIACIPKSNQFFSASRDKTV 127
Cdd:COG2319   65 AAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTV 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663893 128 LMWDLQgSSQPRQQLSGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWDVGTGQCVERASVSRNLVTHLCWVPREPYIVQTS 207
Cdd:COG2319  145 RLWDLA-TGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGS 223

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663893 208 EDKTIRLWDCRGLQMAHVFPTKQHIQTHCEVSVDGHTCVScssgfGGEGCEATLWDLrQTRERMCEYKGHFQTVASCVFL 287
Cdd:COG2319  224 ADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLAS-----GSADGTVRLWDL-ATGELLRTLTGHSGGVNSVAFS 297

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 164663893 288 PKSAalmpMIATSAHDSKVKIWNQDTGACLSTLSlDGSGPLTSLAV 333
Cdd:COG2319  298 PDGK----LLASGSDDGTVRLWDLATGKLLRTLT-GHTGAVRSVAF 338
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 58-344 2.47e-45

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 157.11  E-value: 2.47e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663893  58 IPAHVDTVSVVAAL-NSDLCISGGKDKTAVVYNWKTGHVVRRFIGHEREITKIACIPKSNQFFSASRDKTVLMWDLQgSS 136
Cdd:cd00200    5 LKGHTGGVTCVAFSpDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE-TG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663893 137 QPRQQLSGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWDVGTGQCVERASVSRNLVTHLCWVPREPYIVQTSEDKTIRLWD 216
Cdd:cd00200   84 ECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWD 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663893 217 CRGLQMAHVFPTKQHIQTHCEVSVDGHTCVSCSSgfggeGCEATLWDLRQTRErMCEYKGHFQTVASCVFLPKSAalmpM 296
Cdd:cd00200  164 LRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSS-----DGTIKLWDLSTGKC-LGTLRGHENGVNSVAFSPDGY----L 233

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 164663893 297 IATSAHDSKVKIWNQDTGACLSTLSLdGSGPLTSLAV-GDITSLLCASF 344
Cdd:cd00200  234 LASGSEDGTIRVWDLRTGECVQTLSG-HTNSVTSLAWsPDGKRLASGSA 281
WD40 COG2319
WD40 repeat [General function prediction only];
77-313 2.59e-44

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 157.38  E-value: 2.59e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663893  77 ISGGKDKTAVVYNWKTGHVVRRFIGHEREITKIACIPKSNQFFSASRDKTVLMWDLQGSsQPRQQLSGHAMVVTGLAVSP 156
Cdd:COG2319  178 ASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG-KLLRTLTGHSGSVRSVAFSP 256

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663893 157 DSSQLCTGSRDNSLLLWDVGTGQCVERASVSRNLVTHLCWVPREPYIVQTSEDKTIRLWDCRGLQMAHVFPTKQHIQTHC 236
Cdd:COG2319  257 DGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV 336

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 164663893 237 EVSVDGHTCVScssgfGGEGCEATLWDLrQTRERMCEYKGHFQTVASCVFLPKSaalmPMIATSAHDSKVKIWNQDT 313
Cdd:COG2319  337 AFSPDGKTLAS-----GSDDGTVRLWDL-ATGELLRTLTGHTGAVTSVAFSPDG----RTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 61-310 3.33e-42

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 149.02  E-value: 3.33e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663893  61 HVDTVSVVAAL-NSDLCISGGKDKTAVVYNWKTGHVVRRFIGHEREITKIACIPKSNQFFSASRDKTVLMWDLQgSSQPR 139
Cdd:cd00200   50 HTGPVRDVAASaDGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVE-TGKCL 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663893 140 QQLSGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWDVGTGQCVERASVSRNLVTHLCWVPREPYIVQTSEDKTIRLWDCRG 219
Cdd:cd00200  129 TTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLST 208

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663893 220 LQMAHVFPTKQHIQTHCEVSVDGHTCVSCSsgfggEGCEATLWDLRqTRERMCEYKGHFQTVASCVFLPKSaalmPMIAT 299
Cdd:cd00200  209 GKCLGTLRGHENGVNSVAFSPDGYLLASGS-----EDGTIRVWDLR-TGECVQTLSGHTNSVTSLAWSPDG----KRLAS 278

                        250
                 ....*....|.
gi 164663893 300 SAHDSKVKIWN 310
Cdd:cd00200  279 GSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
59-354 1.74e-40

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 147.37  E-value: 1.74e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663893  59 PAHVDTVSVVAALNSDLCISGGKDKTAVVYNWKTGHVVRRFIGHEREITKIACIPKSNQFFSASRDKTVLMWDLQGsSQP 138
Cdd:COG2319   34 GLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLAT-GLL 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663893 139 RQQLSGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWDVGTGQCVERASVSRNLVTHLCWVPREPYIVQTSEDKTIRLWDCR 218
Cdd:COG2319  113 LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663893 219 GLQMAHVFPTKQHIQTHCEVSVDGHTCVScssgfGGEGCEATLWDLrQTRERMCEYKGHFQTVASCVFLPKSaalmPMIA 298
Cdd:COG2319  193 TGKLLRTLTGHTGAVRSVAFSPDGKLLAS-----GSADGTVRLWDL-ATGKLLRTLTGHSGSVRSVAFSPDG----RLLA 262

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 164663893 299 TSAHDSKVKIWNQDTGACLSTLSlDGSGPLTSLAV-GDITSLLCASFYRGVHLLRMD 354
Cdd:COG2319  263 SGSADGTVRLWDLATGELLRTLT-GHSGGVNSVAFsPDGKLLASGSDDGTVRLWDLA 318
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 96-343 2.12e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 130.92  E-value: 2.12e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663893  96 VRRFIGHEREITKIACIPKSNQFFSASRDKTVLMWDLQGSSQPRQqLSGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWDV 175
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRT-LKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663893 176 GTGQCVERASVSRNLVTHLCWVPREPYIVQTSEDKTIRLWDCRGLQMAHVFPTKQHIQTHCEVSVDGHTCVSCSSgfggE 255
Cdd:cd00200   81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQ----D 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663893 256 GCeATLWDLRQTRERMcEYKGHFQTVASCVFLPKSAalmpMIATSAHDSKVKIWNQDTGACLSTLSLDgSGPLTSLAVGD 335
Cdd:cd00200  157 GT-IKLWDLRTGKCVA-TLTGHTGEVNSVAFSPDGE----KLLSSSSDGTIKLWDLSTGKCLGTLRGH-ENGVNSVAFSP 229


                 ....*...
gi 164663893 336 ITSLLCAS 343
Cdd:cd00200  230 DGYLLASG 237
WD40 COG2319
WD40 repeat [General function prediction only];
68-350 4.26e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 110.77  E-value: 4.26e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663893  68 VAALNSDLCISGGKDKTAVVYNWKTGHVVRRFIGHEREITKIACIPKSNQFFSASRDKTVLMWDLQGSsQPRQQLSGHAM 147
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAG-ALLATLLGHTA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663893 148 VVTGLAVSPDSSQLCTGSRDNSLLLWDVGTGQCVERASVSRNLVTHLCWVPREPYIVQTSEDKTIRLWDCRGLQMAHVFP 227
Cdd:COG2319   80 AVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLT 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663893 228 TKQHIQTHCEVSVDGHTCVScssgfGGEGCEATLWDLRqTRERMCEYKGHFQTVASCVFLPKSAalmpMIATSAHDSKVK 307
Cdd:COG2319  160 GHSGAVTSVAFSPDGKLLAS-----GSDDGTVRLWDLA-TGKLLRTLTGHTGAVRSVAFSPDGK----LLASGSADGTVR 229

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 164663893 308 IWNQDTGACLSTLSlDGSGPLTSLAV-GDITSLLCASFYRGVHL 350
Cdd:COG2319  230 LWDLATGKLLRTLT-GHSGSVRSVAFsPDGRLLASGSADGTVRL 272
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 138-343 6.30e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 99.72  E-value: 6.30e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663893 138 PRQQLSGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWDVGTGQCVERASVSRNLVTHLCWVPREPYIVQTSEDKTIRLWDC 217
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663893 218 RGLQMAHVFptKQHIQ--THCEVSVDGHTCVSCSSgfggeGCEATLWDLRQTRERMCeYKGHFQTVASCVFLPKSaalmP 295
Cdd:cd00200   81 ETGECVRTL--TGHTSyvSSVAFSPDGRILSSSSR-----DKTIKVWDVETGKCLTT-LRGHTDWVNSVAFSPDG----T 148

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 164663893 296 MIATSAHDSKVKIWNQDTGACLSTLSlDGSGPLTSLAVGDITSLLCAS 343
Cdd:cd00200  149 FVASSSQDGTIKLWDLRTGKCVATLT-GHTGEVNSVAFSPDGEKLLSS 195
PTZ00421 PTZ00421
coronin; Provisional
 100-218 6.27e-07

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 51.05  E-value: 6.27e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663893 100 IGHEREITKIACIPKSNQ-FFSASRDKTVLMWDL------QGSSQPRQQLSGHAMVVTGLAVSPDSSQ-LCTGSRDNSLL 171
Cdd:PTZ00421  72 LGQEGPIIDVAFNPFDPQkLFTASEDGTIMGWGIpeegltQNISDPIVHLQGHTKKVGIVSFHPSAMNvLASAGADMVVN 151

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 164663893 172 LWDVGTGQCVERASVSRNLVTHLCWVPREPYIVQTSEDKTIRLWDCR 218
Cdd:PTZ00421 152 VWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPR 198
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 135-174 6.72e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 6.72e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 164663893   135 SSQPRQQLSGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWD 174
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 101-221 3.63e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 48.74  E-value: 3.63e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663893 101 GHEREITKIACIPKSNQFF-SASRDKTVLMWDLQgSSQPRQQLSGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWDVGTGQ 179
Cdd:PTZ00421 123 GHTKKVGIVSFHPSAMNVLaSAGADMVVNVWDVE-RGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGT 201

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 164663893 180 CVERASVSRNLVTHLC-WVPREPYIV----QTSEDKTIRLWDCRGLQ 221
Cdd:PTZ00421 202 IVSSVEAHASAKSQRClWAKRKDLIItlgcSKSQQRQIMLWDTRKMA 248
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 92-131 5.12e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 5.12e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 164663893    92 TGHVVRRFIGHEREITKIACIPKSNQFFSASRDKTVLMWD 131
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
136-174 6.58e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 6.58e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 164663893  136 SQPRQQLSGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWD 174
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 159-331 8.82e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 47.77  E-value: 8.82e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663893 159 SQLCTGSRDNSLLLWDVGTGQCVERASVSRNLVTHLCWVPREPYIVQT-SEDKTIRLWDCRGLQMAHVFPTKQHIqthCE 237
Cdd:PLN00181 546 SQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASgSDDGSVKLWSINQGVSIGTIKTKANI---CC 622

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663893 238 VSVDGHTCVSCSsgFGGEGCEATLWDLRQTRERMCEYKGHFQTVASCVFLPKSAalmpmIATSAHDSKVKIWNqdtgacl 317
Cdd:PLN00181 623 VQFPSESGRSLA--FGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFVDSST-----LVSSSTDNTLKLWD------- 688

                        170
                 ....*....|....*...
gi 164663893 318 stLSLDGSG----PLTSL 331
Cdd:PLN00181 689 --LSMSISGinetPLHSF 704
WD40 pfam00400
WD domain, G-beta repeat;
93-131 1.21e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 1.21e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 164663893   93 GHVVRRFIGHEREITKIACIPKSNQFFSASRDKTVLMWD 131
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 140-204 2.44e-04

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 42.75  E-value: 2.44e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 164663893  140 QQLSGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWDVGTGQCVERAsvSRNLVTHLcwvPREPYIV 204
Cdd:pfam20426 118 QSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVLRGRSSEKR--SRNTQTEF---PRKDHVI 177
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 177-216 6.14e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 6.14e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 164663893   177 TGQCVERASVSRNLVTHLCWVPREPYIVQTSEDKTIRLWD 216
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
178-216 9.83e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 33.47  E-value: 9.83e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 164663893  178 GQCVERASVSRNLVTHLCWVPREPYIVQTSEDKTIRLWD 216
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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