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Conserved domains on  [gi|1996240385|ref|NP_001014241|]
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tRNA endonuclease ANKZF1 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
bVLRF1 pfam18826
Bacteroidetes VLRF1 release factor; Archaeo-eukaryotic release factor domain family belonging ...
 231-375 1.17e-69

Bacteroidetes VLRF1 release factor; Archaeo-eukaryotic release factor domain family belonging to the VLRF1 clade observed primarily in the bacteroidetes bacterial lineage. Contains a conserved glutamine residue in the release factor catalytic loop, suggesting it functions as an active peptidyl-tRNA hydrolase at the ribosome.


:

Pssm-ID: 465880  Cd Length: 143  Bit Score: 224.69  E-value: 1.17e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1996240385 231 YVVLMAAAGHFAGAIFQGREVVAHKTFHRYTVRAKRGTAQGLQDAQGRASRSAGANLRRYNEAMLYKDVRDLLAgpTWSK 310
Cdd:pfam18826   1 WALLMIGGGHFAGAVFSGGEVLAHKTFHRYTTRRKQGGSQSSNDNAKGKAKSAGASLRRYNEQALQEDIRELLS--EWKE 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1996240385 311 ALGEAETILLHAPRSGRSLFFGGQGAPLQRSDFRLWDIPLTTRRPTFGELQRVLHKLTTLQVYDE 375
Cdd:pfam18826  79 DIDKCELIFIRAPGSNRKILFGYEGAPLDKDDPRLRSIPFPTRRPTFSELKRVFSELTTVKVSHK 143
VATC pfam18716
Vms1-associating treble clef domain; Treble clef fold domain found at C-terminus of many, but ...
 705-746 1.23e-17

Vms1-associating treble clef domain; Treble clef fold domain found at C-terminus of many, but not all, Vms1/ANKZF1-like proteins.


:

Pssm-ID: 465846  Cd Length: 43  Bit Score: 76.97  E-value: 1.23e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1996240385 705 VNAGRCWSCGVSLQGLIPFHYLDFSFCSTRCLRDHRSQAGRP 746
Cdd:pfam18716   1 KNYRRCWICGESLLGKVPFHKLDFSYCSTKCLRAHRRAGFAP 42
ANKYR super family cl34000
Ankyrin repeat [Signal transduction mechanisms];
520-622 1.79e-09

Ankyrin repeat [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG0666:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 59.58  E-value: 1.79e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1996240385 520 LLAACRAGEVEVLKLQLATGpVDPGVMSllsaplgSGGFTLLHAAAAAGRGLVVRLLLEAGADPTVHDSRARPPYTVAAD 599
Cdd:COG0666   157 LHLAAANGNLEIVKLLLEAG-ADVNARD-------NDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAE 228

                          90       100
                  ....*....|....*....|...
gi 1996240385 600 RSTRNEFRRFMEKNLDAYDYSKA 622
Cdd:COG0666   229 NGNLEIVKLLLEAGADLNAKDKD 251
 
Name Accession Description Interval E-value
bVLRF1 pfam18826
Bacteroidetes VLRF1 release factor; Archaeo-eukaryotic release factor domain family belonging ...
 231-375 1.17e-69

Bacteroidetes VLRF1 release factor; Archaeo-eukaryotic release factor domain family belonging to the VLRF1 clade observed primarily in the bacteroidetes bacterial lineage. Contains a conserved glutamine residue in the release factor catalytic loop, suggesting it functions as an active peptidyl-tRNA hydrolase at the ribosome.


Pssm-ID: 465880  Cd Length: 143  Bit Score: 224.69  E-value: 1.17e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1996240385 231 YVVLMAAAGHFAGAIFQGREVVAHKTFHRYTVRAKRGTAQGLQDAQGRASRSAGANLRRYNEAMLYKDVRDLLAgpTWSK 310
Cdd:pfam18826   1 WALLMIGGGHFAGAVFSGGEVLAHKTFHRYTTRRKQGGSQSSNDNAKGKAKSAGASLRRYNEQALQEDIRELLS--EWKE 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1996240385 311 ALGEAETILLHAPRSGRSLFFGGQGAPLQRSDFRLWDIPLTTRRPTFGELQRVLHKLTTLQVYDE 375
Cdd:pfam18826  79 DIDKCELIFIRAPGSNRKILFGYEGAPLDKDDPRLRSIPFPTRRPTFSELKRVFSELTTVKVSHK 143
VATC pfam18716
Vms1-associating treble clef domain; Treble clef fold domain found at C-terminus of many, but ...
 705-746 1.23e-17

Vms1-associating treble clef domain; Treble clef fold domain found at C-terminus of many, but not all, Vms1/ANKZF1-like proteins.


Pssm-ID: 465846  Cd Length: 43  Bit Score: 76.97  E-value: 1.23e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1996240385 705 VNAGRCWSCGVSLQGLIPFHYLDFSFCSTRCLRDHRSQAGRP 746
Cdd:pfam18716   1 KNYRRCWICGESLLGKVPFHKLDFSYCSTKCLRAHRRAGFAP 42
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
520-622 1.79e-09

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 59.58  E-value: 1.79e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1996240385 520 LLAACRAGEVEVLKLQLATGpVDPGVMSllsaplgSGGFTLLHAAAAAGRGLVVRLLLEAGADPTVHDSRARPPYTVAAD 599
Cdd:COG0666   157 LHLAAANGNLEIVKLLLEAG-ADVNARD-------NDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAE 228

                          90       100
                  ....*....|....*....|...
gi 1996240385 600 RSTRNEFRRFMEKNLDAYDYSKA 622
Cdd:COG0666   229 NGNLEIVKLLLEAGADLNAKDKD 251
Ank_2 pfam12796
Ankyrin repeats (3 copies);
520-587 4.14e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 45.49  E-value: 4.14e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1996240385 520 LLAACRAGEVEVLKLQLATGPVDpgvmsllsapLGSGGFTLLHAAAAAGRGLVVRLLLEAGADPTVHD 587
Cdd:pfam12796  34 LHLAAKNGHLEIVKLLLEHADVN----------LKDNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 557-629 2.05e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 47.97  E-value: 2.05e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1996240385 557 GFTLLHAAAAAGRGLVVRLLLEAGADPTVHDSRARPPYTVAADRSTRNEFRRFMEKNLDAYDYSKARVPGPLT 629
Cdd:PTZ00322  115 GRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFELGANAKPDSFT 187
 
Name Accession Description Interval E-value
bVLRF1 pfam18826
Bacteroidetes VLRF1 release factor; Archaeo-eukaryotic release factor domain family belonging ...
 231-375 1.17e-69

Bacteroidetes VLRF1 release factor; Archaeo-eukaryotic release factor domain family belonging to the VLRF1 clade observed primarily in the bacteroidetes bacterial lineage. Contains a conserved glutamine residue in the release factor catalytic loop, suggesting it functions as an active peptidyl-tRNA hydrolase at the ribosome.


Pssm-ID: 465880  Cd Length: 143  Bit Score: 224.69  E-value: 1.17e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1996240385 231 YVVLMAAAGHFAGAIFQGREVVAHKTFHRYTVRAKRGTAQGLQDAQGRASRSAGANLRRYNEAMLYKDVRDLLAgpTWSK 310
Cdd:pfam18826   1 WALLMIGGGHFAGAVFSGGEVLAHKTFHRYTTRRKQGGSQSSNDNAKGKAKSAGASLRRYNEQALQEDIRELLS--EWKE 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1996240385 311 ALGEAETILLHAPRSGRSLFFGGQGAPLQRSDFRLWDIPLTTRRPTFGELQRVLHKLTTLQVYDE 375
Cdd:pfam18826  79 DIDKCELIFIRAPGSNRKILFGYEGAPLDKDDPRLRSIPFPTRRPTFSELKRVFSELTTVKVSHK 143
VATC pfam18716
Vms1-associating treble clef domain; Treble clef fold domain found at C-terminus of many, but ...
 705-746 1.23e-17

Vms1-associating treble clef domain; Treble clef fold domain found at C-terminus of many, but not all, Vms1/ANKZF1-like proteins.


Pssm-ID: 465846  Cd Length: 43  Bit Score: 76.97  E-value: 1.23e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1996240385 705 VNAGRCWSCGVSLQGLIPFHYLDFSFCSTRCLRDHRSQAGRP 746
Cdd:pfam18716   1 KNYRRCWICGESLLGKVPFHKLDFSYCSTKCLRAHRRAGFAP 42
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
520-622 1.79e-09

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 59.58  E-value: 1.79e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1996240385 520 LLAACRAGEVEVLKLQLATGpVDPGVMSllsaplgSGGFTLLHAAAAAGRGLVVRLLLEAGADPTVHDSRARPPYTVAAD 599
Cdd:COG0666   157 LHLAAANGNLEIVKLLLEAG-ADVNARD-------NDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAE 228

                          90       100
                  ....*....|....*....|...
gi 1996240385 600 RSTRNEFRRFMEKNLDAYDYSKA 622
Cdd:COG0666   229 NGNLEIVKLLLEAGADLNAKDKD 251
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
515-598 3.04e-08

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 55.73  E-value: 3.04e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1996240385 515 ELWDMLLAACRAGEVEVLKLQLATGpVDPGVmsllsapLGSGGFTLLHAAAAAGRGLVVRLLLEAGADPTVHDSRARPPY 594
Cdd:COG0666    86 GGNTLLHAAARNGDLEIVKLLLEAG-ADVNA-------RDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPL 157


                  ....
gi 1996240385 595 TVAA 598
Cdd:COG0666   158 HLAA 161
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
517-600 3.98e-08

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 55.35  E-value: 3.98e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1996240385 517 WDMLLAACRAGEVEVLKLQLATGpVDPGVmsllsapLGSGGFTLLHAAAAAGRGLVVRLLLEAGADPTVHDSRARPPYTV 596
Cdd:COG0666   121 ETPLHLAAYNGNLEIVKLLLEAG-ADVNA-------QDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHL 192


                  ....
gi 1996240385 597 AADR 600
Cdd:COG0666   193 AAEN 196
Ank_2 pfam12796
Ankyrin repeats (3 copies);
520-587 4.14e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 45.49  E-value: 4.14e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1996240385 520 LLAACRAGEVEVLKLQLATGPVDpgvmsllsapLGSGGFTLLHAAAAAGRGLVVRLLLEAGADPTVHD 587
Cdd:pfam12796  34 LHLAAKNGHLEIVKLLLEHADVN----------LKDNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 557-629 2.05e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 47.97  E-value: 2.05e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1996240385 557 GFTLLHAAAAAGRGLVVRLLLEAGADPTVHDSRARPPYTVAADRSTRNEFRRFMEKNLDAYDYSKARVPGPLT 629
Cdd:PTZ00322  115 GRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFELGANAKPDSFT 187
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
516-600 2.34e-05

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 46.87  E-value: 2.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1996240385 516 LWDMLLAACRAGEVEVLKLQLATGPVDpgvmsllsAPLGSGGFTLLHAAAAAGRGLVVRLLLEAGADPTVHDSRARPPYT 595
Cdd:COG0666    54 GALLLLAAALAGDLLVALLLLAAGADI--------NAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLH 125


                  ....*
gi 1996240385 596 VAADR 600
Cdd:COG0666   126 LAAYN 130
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 557-587 1.17e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 39.97  E-value: 1.17e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1996240385 557 GFTLLHAAAA-AGRGLVVRLLLEAGADPTVHD 587
Cdd:pfam00023   2 GNTPLHLAAGrRGNLEIVKLLLSKGADVNARD 33
Ank_2 pfam12796
Ankyrin repeats (3 copies);
520-578 4.60e-03

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 37.02  E-value: 4.60e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1996240385 520 LLAACRAGEVEVLKLqLATGPVDPGVMSLLsaplgsgGFTLLHAAAAAGRGLVVRLLLE 578
Cdd:pfam12796   1 LHLAAKNGNLELVKL-LLENGADANLQDKN-------GRTALHLAAKNGHLEIVKLLLE 51
Ank_5 pfam13857
Ankyrin repeats (many copies);
536-597 5.98e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 35.79  E-value: 5.98e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1996240385 536 LATGPVDPGVmsllsapLGSGGFTLLHAAAAAGRGLVVRLLLEAGADPTVHDSRARPPYTVA 597
Cdd:pfam13857   2 LEHGPIDLNR-------LDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 557-583 8.05e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 34.54  E-value: 8.05e-03
                          10        20
                  ....*....|....*....|....*..
gi 1996240385 557 GFTLLHAAAAAGRGLVVRLLLEAGADP 583
Cdd:pfam13606   2 GNTPLHLAARNGRLEIVKLLLENGADI 28
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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