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Conserved domains on  [gi|66571305|ref|NP_001019312|]
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nuclear RNA export factor 3 [Mus musculus]

Protein Classification

nuclear transport factor 2 family protein( domain architecture ID 11182047)

nuclear transport factor 2 (NTF2) family protein with a SnoaL-like polyketide cyclase domain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tap-RNA_bind pfam09162
Tap, RNA-binding; Members of this family adopt a structure consisting of an alpha+beta ...
 102-179 1.83e-38

Tap, RNA-binding; Members of this family adopt a structure consisting of an alpha+beta sandwich with an antiparallel beta-sheet, arranged in a 2(beta-alpha-beta) motif. They are mainly found in mRNA export factors, and mediate the sequence nonspecific nuclear export of cellular mRNAs as well as the sequence-specific export of retroviral mRNAs bearing the constitutive transport element.


:

Pssm-ID: 462696  Cd Length: 80  Bit Score: 135.76  E-value: 1.83e-38
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 66571305   102 WFKVTIPFGIKYDKKWLLNLIQSQCSIPFTPVQFHYEKMQAHFFVDNPNIAFMLKAISDKILDETDNKPQSHRTPSVI 179
Cdd:pfam09162   1 WFKVTIPYGKKYDKKWLLNSIQSLCSVPFTPVDFHYEKNRAVFFVEDASTASALKKVSRKITDEDGRKISIFVNPSAP 78
TAP_C smart00804
C-terminal domain of vertebrate Tap protein; The vertebrate Tap protein is a member of the NXF ...
 485-547 3.21e-21

C-terminal domain of vertebrate Tap protein; The vertebrate Tap protein is a member of the NXF family of shuttling transport receptors for the nuclear export of mRNA. Its most C-terminal domain is important for binding to FG repeat-containing nuclear pore proteins (FG-nucleoporins) and is sufficient to mediate shuttling. This domain forms a compact four-helix fold related to that of a UBA domain.


:

Pssm-ID: 197882  Cd Length: 63  Bit Score: 87.36  E-value: 3.21e-21
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 66571305    485 STSYLPSFSQDQQEMVPTFCAQSGVNVDRSQKSLHDDQWNYNRAIQSLALLKVEDTISEDKFT 547
Cdd:smart00804   1 PASPKPTLSPEQQEMVQAFSAQTGMNAEYSQMCLEDNNWDYERALKNFTELKSEGSIPPEAFA 63
NTF2_like super family cl09109
Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 ...
 314-470 8.05e-12

Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of divergent evolution wherein the proteins have many common structural details but diverge greatly in their function. For example, nuclear transport factor 2 (NTF2) mediates the nuclear import of RanGDP and binds to both RanGDP and FxFG repeat-containing nucleoporins while Ketosteroid isomerases catalyze the isomerization of delta-5-3-ketosteroid to delta-4-3-ketosteroid, by intramolecular transfer of the C4-beta proton to the C6-beta position. While the function of the beta sub-unit of the Ring hydroxylating dioxygenases is not known, Scytalone Dehydratases catalyzes two reactions in the biosynthetic pathway that produces fungal melanin. Members of the NTF2-like superfamily are widely distributed among bacteria, archaea and eukaryotes.


The actual alignment was detected with superfamily member cd00780:

Pssm-ID: 471850  Cd Length: 119  Bit Score: 62.30  E-value: 8.05e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66571305 314 SIKTMVLQFLKQYYFIYDNgDRQGLLNAYHPEACFTLTIPfssidlsmnslceyfkfsrnmkilkDPYMRRQllkhkkcD 393
Cdd:cd00780   1 SAEDVAKAFVQQYYSIFDN-NREGLHRLYGDTSMLSREGM-------------------------KQVTGRD-------A 47

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 66571305 394 IIHFLRTLP--KTQHDLTSfvVDICLQTEKMLCFSVSGLFKEVDNSaqgcMHAFTRIFVVTHDNSSeLCIINDKLSVTN 470
Cdd:cd00780  48 IVEKLSSLPfqKTKHKITT--VDSQPTPSGGVIVMVTGSLKLDEQP----PRKFSQTFVLAPQNGG-YFVLNDIFRFVD 119
 
Name Accession Description Interval E-value
Tap-RNA_bind pfam09162
Tap, RNA-binding; Members of this family adopt a structure consisting of an alpha+beta ...
 102-179 1.83e-38

Tap, RNA-binding; Members of this family adopt a structure consisting of an alpha+beta sandwich with an antiparallel beta-sheet, arranged in a 2(beta-alpha-beta) motif. They are mainly found in mRNA export factors, and mediate the sequence nonspecific nuclear export of cellular mRNAs as well as the sequence-specific export of retroviral mRNAs bearing the constitutive transport element.


Pssm-ID: 462696  Cd Length: 80  Bit Score: 135.76  E-value: 1.83e-38
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 66571305   102 WFKVTIPFGIKYDKKWLLNLIQSQCSIPFTPVQFHYEKMQAHFFVDNPNIAFMLKAISDKILDETDNKPQSHRTPSVI 179
Cdd:pfam09162   1 WFKVTIPYGKKYDKKWLLNSIQSLCSVPFTPVDFHYEKNRAVFFVEDASTASALKKVSRKITDEDGRKISIFVNPSAP 78
TAP_C smart00804
C-terminal domain of vertebrate Tap protein; The vertebrate Tap protein is a member of the NXF ...
 485-547 3.21e-21

C-terminal domain of vertebrate Tap protein; The vertebrate Tap protein is a member of the NXF family of shuttling transport receptors for the nuclear export of mRNA. Its most C-terminal domain is important for binding to FG repeat-containing nuclear pore proteins (FG-nucleoporins) and is sufficient to mediate shuttling. This domain forms a compact four-helix fold related to that of a UBA domain.


Pssm-ID: 197882  Cd Length: 63  Bit Score: 87.36  E-value: 3.21e-21
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 66571305    485 STSYLPSFSQDQQEMVPTFCAQSGVNVDRSQKSLHDDQWNYNRAIQSLALLKVEDTISEDKFT 547
Cdd:smart00804   1 PASPKPTLSPEQQEMVQAFSAQTGMNAEYSQMCLEDNNWDYERALKNFTELKSEGSIPPEAFA 63
UBA_TAP-C cd14342
UBA-like domain found in nuclear RNA export factor NXF1, NXF2 and similar proteins; The NXF ...
 496-546 2.45e-14

UBA-like domain found in nuclear RNA export factor NXF1, NXF2 and similar proteins; The NXF family of mRNA nuclear export factors including vertebrate NXF1 (also called tip-associated protein or mRNA export factor TAP), NXF2 (also called cancer/testis antigen CT39 or TAP-like protein TAPL-2), Caenorhabditis elegans NXF1 (ceNXF1), Saccharomyces cerevisiae mRNA nuclear export factor Mex67p and similar proteins. NXF proteins can stimulate nuclear export of mRNAs and facilitate the export of unspliced viral mRNA containing the constitutive transport element. It is a multi-domain protein with a nuclear localization sequence (NLS), a non-canonical mRNA-binding domain, and four leucine-rich repeats (LLR) at the N-terminal region. Its C-terminal part contains a NTF2-like domain and a ubiquitin-associated (UBA)-like domain, joined by flexible Pro-rich linker. Caenorhabditis elegans NXF1 are essential for the nuclear export of poly(A)+mRNA. In budding yeast, Mex67p binds mRNAs through its adaptor Yra1/REF. It also interacts directly with Nab2, an essential shuttling mRNA-binding protein required for export. Moreover, Mex67p associates with both nuclear pore protein (nucleoporin) FG repeats and Hpr1, a component of the TREX/THO complex linking transcription and export.


Pssm-ID: 270527  Cd Length: 51  Bit Score: 67.22  E-value: 2.45e-14
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 66571305 496 QQEMVPTFCAQSGVNVDRSQKSLHDDQWNYNRAIQSLALLKVEDTISEDKF 546
Cdd:cd14342   1 QQQMVQQLSAQTGMNLEWSQKCLEDNGWDYEKALANFEELKAQGKIPPEAF 51
TAP_C pfam03943
TAP C-terminal domain; The vertebrate Tap protein is a member of the NXF family of shuttling ...
 498-546 3.56e-12

TAP C-terminal domain; The vertebrate Tap protein is a member of the NXF family of shuttling transport receptors for nuclear export of mRNA. Tap has a modular structure, and its most C-terminal domain is important for binding to FG repeat-containing nuclear pore proteins (FG-nucleoporins) and is sufficient to mediate nuclear shuttling. The structure of the C-terminal domain is composed of four helices. The structure is related to the UBA domain.


Pssm-ID: 461102  Cd Length: 49  Bit Score: 61.02  E-value: 3.56e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 66571305   498 EMVPTFCAQSGVNVDRSQKSLHDDQWNYNRAIQSLALLKVEDTISEDKF 546
Cdd:pfam03943   1 EMVQQFSQQTGMNLEWSEKCLEQNNWDYERALQNFTELKAQGKIPPEAF 49
NTF2 cd00780
Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of ...
 314-470 8.05e-12

Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many soluble factors that includes GDP-binding protein Ran (RanGDP). RanGDP is required for both import and export of proteins and poly(A) RNA. RanGDP also has been implicated in cell cycle control, specifically in mitotic spindle assembly. In interphase cells, RanGDP is predominately nuclear and thought to be GTP bound, but it is also present in the cytoplasm, probably in the GDP-bound state. NTF2 mediates the nuclear import of RanGDP. NTF2 binds to both RanGDP and FxFG repeat-containing nucleoporins.


Pssm-ID: 238403  Cd Length: 119  Bit Score: 62.30  E-value: 8.05e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66571305 314 SIKTMVLQFLKQYYFIYDNgDRQGLLNAYHPEACFTLTIPfssidlsmnslceyfkfsrnmkilkDPYMRRQllkhkkcD 393
Cdd:cd00780   1 SAEDVAKAFVQQYYSIFDN-NREGLHRLYGDTSMLSREGM-------------------------KQVTGRD-------A 47

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 66571305 394 IIHFLRTLP--KTQHDLTSfvVDICLQTEKMLCFSVSGLFKEVDNSaqgcMHAFTRIFVVTHDNSSeLCIINDKLSVTN 470
Cdd:cd00780  48 IVEKLSSLPfqKTKHKITT--VDSQPTPSGGVIVMVTGSLKLDEQP----PRKFSQTFVLAPQNGG-YFVLNDIFRFVD 119
NTF2 pfam02136
Nuclear transport factor 2 (NTF2) domain; This family includes the NTF2-like ...
 319-464 1.08e-07

Nuclear transport factor 2 (NTF2) domain; This family includes the NTF2-like Delta-5-3-ketosteroid isomerase proteins.


Pssm-ID: 396625  Cd Length: 116  Bit Score: 50.43  E-value: 1.08e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66571305   319 VLQFLKQYYFIYDNGDRQGLLNAYHPEACFtLTIPFSsidlsmnslceyfkfsrnmkilkDPYMRRQllkhkkcDIIHFL 398
Cdd:pfam02136   2 GNAFVQQYYAALDAHDPEGLHALYADDASM-LTPPGS-----------------------DPVVGLE-------AINEFF 50

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 66571305   399 RTLPKT--QHDLTSFVVDIClQTEKMLCFSVSGLFKEVDNSAqgcmHAFTRIFVVTHDNSSeLCIIND 464
Cdd:pfam02136  51 DSLPFTriQHKITSVDSQPA-SLKDGVLVMVTGELTVDDFPR----RRFSQTFLLAPQRGG-YFVLND 112
 
Name Accession Description Interval E-value
Tap-RNA_bind pfam09162
Tap, RNA-binding; Members of this family adopt a structure consisting of an alpha+beta ...
 102-179 1.83e-38

Tap, RNA-binding; Members of this family adopt a structure consisting of an alpha+beta sandwich with an antiparallel beta-sheet, arranged in a 2(beta-alpha-beta) motif. They are mainly found in mRNA export factors, and mediate the sequence nonspecific nuclear export of cellular mRNAs as well as the sequence-specific export of retroviral mRNAs bearing the constitutive transport element.


Pssm-ID: 462696  Cd Length: 80  Bit Score: 135.76  E-value: 1.83e-38
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 66571305   102 WFKVTIPFGIKYDKKWLLNLIQSQCSIPFTPVQFHYEKMQAHFFVDNPNIAFMLKAISDKILDETDNKPQSHRTPSVI 179
Cdd:pfam09162   1 WFKVTIPYGKKYDKKWLLNSIQSLCSVPFTPVDFHYEKNRAVFFVEDASTASALKKVSRKITDEDGRKISIFVNPSAP 78
TAP_C smart00804
C-terminal domain of vertebrate Tap protein; The vertebrate Tap protein is a member of the NXF ...
 485-547 3.21e-21

C-terminal domain of vertebrate Tap protein; The vertebrate Tap protein is a member of the NXF family of shuttling transport receptors for the nuclear export of mRNA. Its most C-terminal domain is important for binding to FG repeat-containing nuclear pore proteins (FG-nucleoporins) and is sufficient to mediate shuttling. This domain forms a compact four-helix fold related to that of a UBA domain.


Pssm-ID: 197882  Cd Length: 63  Bit Score: 87.36  E-value: 3.21e-21
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 66571305    485 STSYLPSFSQDQQEMVPTFCAQSGVNVDRSQKSLHDDQWNYNRAIQSLALLKVEDTISEDKFT 547
Cdd:smart00804   1 PASPKPTLSPEQQEMVQAFSAQTGMNAEYSQMCLEDNNWDYERALKNFTELKSEGSIPPEAFA 63
UBA_TAP-C cd14342
UBA-like domain found in nuclear RNA export factor NXF1, NXF2 and similar proteins; The NXF ...
 496-546 2.45e-14

UBA-like domain found in nuclear RNA export factor NXF1, NXF2 and similar proteins; The NXF family of mRNA nuclear export factors including vertebrate NXF1 (also called tip-associated protein or mRNA export factor TAP), NXF2 (also called cancer/testis antigen CT39 or TAP-like protein TAPL-2), Caenorhabditis elegans NXF1 (ceNXF1), Saccharomyces cerevisiae mRNA nuclear export factor Mex67p and similar proteins. NXF proteins can stimulate nuclear export of mRNAs and facilitate the export of unspliced viral mRNA containing the constitutive transport element. It is a multi-domain protein with a nuclear localization sequence (NLS), a non-canonical mRNA-binding domain, and four leucine-rich repeats (LLR) at the N-terminal region. Its C-terminal part contains a NTF2-like domain and a ubiquitin-associated (UBA)-like domain, joined by flexible Pro-rich linker. Caenorhabditis elegans NXF1 are essential for the nuclear export of poly(A)+mRNA. In budding yeast, Mex67p binds mRNAs through its adaptor Yra1/REF. It also interacts directly with Nab2, an essential shuttling mRNA-binding protein required for export. Moreover, Mex67p associates with both nuclear pore protein (nucleoporin) FG repeats and Hpr1, a component of the TREX/THO complex linking transcription and export.


Pssm-ID: 270527  Cd Length: 51  Bit Score: 67.22  E-value: 2.45e-14
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 66571305 496 QQEMVPTFCAQSGVNVDRSQKSLHDDQWNYNRAIQSLALLKVEDTISEDKF 546
Cdd:cd14342   1 QQQMVQQLSAQTGMNLEWSQKCLEDNGWDYEKALANFEELKAQGKIPPEAF 51
TAP_C pfam03943
TAP C-terminal domain; The vertebrate Tap protein is a member of the NXF family of shuttling ...
 498-546 3.56e-12

TAP C-terminal domain; The vertebrate Tap protein is a member of the NXF family of shuttling transport receptors for nuclear export of mRNA. Tap has a modular structure, and its most C-terminal domain is important for binding to FG repeat-containing nuclear pore proteins (FG-nucleoporins) and is sufficient to mediate nuclear shuttling. The structure of the C-terminal domain is composed of four helices. The structure is related to the UBA domain.


Pssm-ID: 461102  Cd Length: 49  Bit Score: 61.02  E-value: 3.56e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 66571305   498 EMVPTFCAQSGVNVDRSQKSLHDDQWNYNRAIQSLALLKVEDTISEDKF 546
Cdd:pfam03943   1 EMVQQFSQQTGMNLEWSEKCLEQNNWDYERALQNFTELKAQGKIPPEAF 49
NTF2 cd00780
Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of ...
 314-470 8.05e-12

Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many soluble factors that includes GDP-binding protein Ran (RanGDP). RanGDP is required for both import and export of proteins and poly(A) RNA. RanGDP also has been implicated in cell cycle control, specifically in mitotic spindle assembly. In interphase cells, RanGDP is predominately nuclear and thought to be GTP bound, but it is also present in the cytoplasm, probably in the GDP-bound state. NTF2 mediates the nuclear import of RanGDP. NTF2 binds to both RanGDP and FxFG repeat-containing nucleoporins.


Pssm-ID: 238403  Cd Length: 119  Bit Score: 62.30  E-value: 8.05e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66571305 314 SIKTMVLQFLKQYYFIYDNgDRQGLLNAYHPEACFTLTIPfssidlsmnslceyfkfsrnmkilkDPYMRRQllkhkkcD 393
Cdd:cd00780   1 SAEDVAKAFVQQYYSIFDN-NREGLHRLYGDTSMLSREGM-------------------------KQVTGRD-------A 47

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 66571305 394 IIHFLRTLP--KTQHDLTSfvVDICLQTEKMLCFSVSGLFKEVDNSaqgcMHAFTRIFVVTHDNSSeLCIINDKLSVTN 470
Cdd:cd00780  48 IVEKLSSLPfqKTKHKITT--VDSQPTPSGGVIVMVTGSLKLDEQP----PRKFSQTFVLAPQNGG-YFVLNDIFRFVD 119
NTF2 pfam02136
Nuclear transport factor 2 (NTF2) domain; This family includes the NTF2-like ...
 319-464 1.08e-07

Nuclear transport factor 2 (NTF2) domain; This family includes the NTF2-like Delta-5-3-ketosteroid isomerase proteins.


Pssm-ID: 396625  Cd Length: 116  Bit Score: 50.43  E-value: 1.08e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66571305   319 VLQFLKQYYFIYDNGDRQGLLNAYHPEACFtLTIPFSsidlsmnslceyfkfsrnmkilkDPYMRRQllkhkkcDIIHFL 398
Cdd:pfam02136   2 GNAFVQQYYAALDAHDPEGLHALYADDASM-LTPPGS-----------------------DPVVGLE-------AINEFF 50

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 66571305   399 RTLPKT--QHDLTSFVVDIClQTEKMLCFSVSGLFKEVDNSAqgcmHAFTRIFVVTHDNSSeLCIIND 464
Cdd:pfam02136  51 DSLPFTriQHKITSVDSQPA-SLKDGVLVMVTGELTVDDFPR----RRFSQTFLLAPQRGG-YFVLND 112
NTF2_like cd00531
Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 ...
 319-465 6.88e-05

Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of divergent evolution wherein the proteins have many common structural details but diverge greatly in their function. For example, nuclear transport factor 2 (NTF2) mediates the nuclear import of RanGDP and binds to both RanGDP and FxFG repeat-containing nucleoporins while Ketosteroid isomerases catalyze the isomerization of delta-5-3-ketosteroid to delta-4-3-ketosteroid, by intramolecular transfer of the C4-beta proton to the C6-beta position. While the function of the beta sub-unit of the Ring hydroxylating dioxygenases is not known, Scytalone Dehydratases catalyzes two reactions in the biosynthetic pathway that produces fungal melanin. Members of the NTF2-like superfamily are widely distributed among bacteria, archaea and eukaryotes.


Pssm-ID: 238296 [Multi-domain]  Cd Length: 124  Bit Score: 42.50  E-value: 6.88e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66571305 319 VLQFLKQYYFIYDNGDRQGLLNAYHPEACFTLTIPFSSIDlsmnslCEYFKFSRNMKILKdpymrrqllkhkkcdiihfL 398
Cdd:cd00531   1 AEQFLYRYARLLDAGDREWLALLYADDAYFEPPGGDGLIY------PDDGREAIEDRVRR-------------------L 55

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 66571305 399 RTLPKTQHDLTSfVVDICLQTEKML-CFSVSGLFkEVDNSAQGCMHAFTRIFVVThDNSSELCIINDK 465
Cdd:cd00531  56 PFGPSRTRHLVS-NVDVQPGDDGEGvVVSVFGVL-RTRGDGEQDVFAGGQTFVLR-PQGGGGKIANRR 120
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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