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Conserved domains on  [gi|71480146|ref|NP_001020254|]
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reproductive homeobox on X chromosome, 12 [Mus musculus]

Protein Classification

homeobox domain-containing protein( domain architecture ID 10052840)

homeobox domain-containing protein may be involved in the transcriptional regulation of key eukaryotic developmental processes

Gene Ontology:  GO:0003677|GO:0006357|GO:0043565
PubMed:  1357790|26464018|21557080

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 107-169 4.66e-16

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


:

Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 68.81  E-value: 4.66e-16
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 71480146 107 RRTRPRiqlgFTPRQLNELEDFFEKTKYPDALTRKNLAKHLYLAESKVQRWFKKRRAHYRKEQ 169
Cdd:cd00086   1 RRKRTR----FTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
 
Name Accession Description Interval E-value
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 107-169 4.66e-16

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 68.81  E-value: 4.66e-16
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 71480146 107 RRTRPRiqlgFTPRQLNELEDFFEKTKYPDALTRKNLAKHLYLAESKVQRWFKKRRAHYRKEQ 169
Cdd:cd00086   1 RRKRTR----FTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
Homeodomain pfam00046
Homeodomain;
107-167 3.97e-15

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 66.37  E-value: 3.97e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 71480146   107 RRTRPRiqlgFTPRQLNELEDFFEKTKYPDALTRKNLAKHLYLAESKVQRWFKKRRAHYRK 167
Cdd:pfam00046   1 RRKRTT----FTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 107-166 4.56e-14

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 63.42  E-value: 4.56e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 71480146    107 RRTRPRiqlgFTPRQLNELEDFFEKTKYPDALTRKNLAKHLYLAESKVQRWFKKRRAHYR 166
Cdd:smart00389   2 RRKRTS----FTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
82-186 2.52e-08

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 50.90  E-value: 2.52e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71480146  82 SHQGSGDPQPEEKQKNSAAARVPQVRRTRpriqlgftpRQLNELEDFFEKTKYPDALTRKNLAKHLYLAESKVQRWFKKR 161
Cdd:COG5576  32 VEAADSEMKLERKQDGSSPPKSKRRRTTD---------EQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNK 102

                        90       100
                ....*....|....*....|....*
gi 71480146 162 RAHYRKEQQSQVLQCASADGQDAMQ 186
Cdd:COG5576 103 RAKEKKKRSGKVEQRPGEEEADLAK 127
 
Name Accession Description Interval E-value
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 107-169 4.66e-16

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 68.81  E-value: 4.66e-16
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 71480146 107 RRTRPRiqlgFTPRQLNELEDFFEKTKYPDALTRKNLAKHLYLAESKVQRWFKKRRAHYRKEQ 169
Cdd:cd00086   1 RRKRTR----FTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
Homeodomain pfam00046
Homeodomain;
107-167 3.97e-15

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 66.37  E-value: 3.97e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 71480146   107 RRTRPRiqlgFTPRQLNELEDFFEKTKYPDALTRKNLAKHLYLAESKVQRWFKKRRAHYRK 167
Cdd:pfam00046   1 RRKRTT----FTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 107-166 4.56e-14

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 63.42  E-value: 4.56e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 71480146    107 RRTRPRiqlgFTPRQLNELEDFFEKTKYPDALTRKNLAKHLYLAESKVQRWFKKRRAHYR 166
Cdd:smart00389   2 RRKRTS----FTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
82-186 2.52e-08

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 50.90  E-value: 2.52e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71480146  82 SHQGSGDPQPEEKQKNSAAARVPQVRRTRpriqlgftpRQLNELEDFFEKTKYPDALTRKNLAKHLYLAESKVQRWFKKR 161
Cdd:COG5576  32 VEAADSEMKLERKQDGSSPPKSKRRRTTD---------EQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNK 102

                        90       100
                ....*....|....*....|....*
gi 71480146 162 RAHYRKEQQSQVLQCASADGQDAMQ 186
Cdd:COG5576 103 RAKEKKKRSGKVEQRPGEEEADLAK 127
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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