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Conserved domains on  [gi|71043752|ref|NP_001020826|]
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UMP-CMP kinase [Rattus norvegicus]

Protein Classification

nucleoside monophosphate kinase( domain architecture ID 11492277)

nucleoside monophosphate kinase catalyzes the transfer of the terminal phosphoryl group from a nucleoside triphosphate, usually ATP, to a nucleoside monophosphate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UMP_CMP_kin_fam TIGR01359
UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of ...
 36-224 1.61e-105

UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of UMP-CMP kinase, as well as others proteins with unknown specificity, some currently designated adenylate kinase. All known members are eukaryotic.


:

Pssm-ID: 273576 [Multi-domain]  Cd Length: 185  Bit Score: 301.98  E-value: 1.61e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043752    36 VVFVLGGPGAGKGTQCARIVEKYGYTHLSAGELLRDERKNPDSQYGELIEKYIKEGKIVPVEITISLLKREMDqtmaANA 115
Cdd:TIGR01359   1 VVFVLGGPGSGKGTQCAKIVENFGFTHLSAGDLLRAEIKREGSENGSLIESYIKEGKIVPSEVTVELLKKAIQ----EDG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043752   116 QKNKFLIDGFPRNQDNLQGWNKTMDGKADVSFVLFFDCNNEICIDRCLERGKSSGRSDDNRESLEKRIQTYLESTKPIID 195
Cdd:TIGR01359  77 SSKKFLIDGFPRNEENLEAWEKLMDNKVNFKFVLFFDCPEETMIKRLLKRGQTSGRVDDNIETLKKRFRTYNEETLPIIE 156

                         170       180
                  ....*....|....*....|....*....
gi 71043752   196 LYEEMGKVKKIDASKSVDEVFGDVMKIFD 224
Cdd:TIGR01359 157 HFENKGKVKEINAEGSVEEVFEDVEKIFA 185
 
Name Accession Description Interval E-value
UMP_CMP_kin_fam TIGR01359
UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of ...
 36-224 1.61e-105

UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of UMP-CMP kinase, as well as others proteins with unknown specificity, some currently designated adenylate kinase. All known members are eukaryotic.


Pssm-ID: 273576 [Multi-domain]  Cd Length: 185  Bit Score: 301.98  E-value: 1.61e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043752    36 VVFVLGGPGAGKGTQCARIVEKYGYTHLSAGELLRDERKNPDSQYGELIEKYIKEGKIVPVEITISLLKREMDqtmaANA 115
Cdd:TIGR01359   1 VVFVLGGPGSGKGTQCAKIVENFGFTHLSAGDLLRAEIKREGSENGSLIESYIKEGKIVPSEVTVELLKKAIQ----EDG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043752   116 QKNKFLIDGFPRNQDNLQGWNKTMDGKADVSFVLFFDCNNEICIDRCLERGKSSGRSDDNRESLEKRIQTYLESTKPIID 195
Cdd:TIGR01359  77 SSKKFLIDGFPRNEENLEAWEKLMDNKVNFKFVLFFDCPEETMIKRLLKRGQTSGRVDDNIETLKKRFRTYNEETLPIIE 156

                         170       180
                  ....*....|....*....|....*....
gi 71043752   196 LYEEMGKVKKIDASKSVDEVFGDVMKIFD 224
Cdd:TIGR01359 157 HFENKGKVKEINAEGSVEEVFEDVEKIFA 185
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 36-215 2.59e-69

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 210.56  E-value: 2.59e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043752  36 VVFVLGGPGAGKGTQCARIVEKYGYTHLSAGELLRDERKNpDSQYGELIEKYIKEGKIVPVEITISLLKREMDQtmaaNA 115
Cdd:cd01428   1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIAS-GTELGKKAKEYIDSGKLVPDEIVIKLLKERLKK----PD 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043752 116 QKNKFLIDGFPRNQDNLQGWNKTMDGKADVSFVLFFDCNNEICIDRCLERGKS-------------------SGRSDDNR 176
Cdd:cd01428  76 CKKGFILDGFPRTVDQAEALDELLDEGIKPDKVIELDVPDEVLIERILGRRICpvsgrvyhlgkddvtgeplSQRSDDNE 155

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 71043752 177 ESLEKRIQTYLESTKPIIDLYEEMGKVKKIDASKSVDEV 215
Cdd:cd01428 156 ETIKKRLEVYKEQTAPLIDYYKKKGKLVEIDGSGDIDEV 194
ADK pfam00406
Adenylate kinase;
39-199 2.72e-56

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 177.12  E-value: 2.72e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043752    39 VLGGPGAGKGTQCARIVEKYGYTHLSAGELLRDERKNpDSQYGELIEKYIKEGKIVPVEITISLLKREMDQtmaaNAQKN 118
Cdd:pfam00406   1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKS-GTELGKEAKEYMDKGELVPDEVVVGLVKERLEQ----NDCKN 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043752   119 KFLIDGFPRNQDNLQGWNKTMDGKADVSFVLFFDCNNEICIDRCLERGKS---------------------------SGR 171
Cdd:pfam00406  76 GFLLDGFPRTVPQAEALEELLERGIKLDYVIEFDVPDEVLVERLTGRRIHpnsgrsyhlefnppkvpgkddvtgeplVQR 155

                         170       180
                  ....*....|....*....|....*...
gi 71043752   172 SDDNRESLEKRIQTYLESTKPIIDLYEE 199
Cdd:pfam00406 156 SDDNEETVKKRLETYHKQTKPLIDYYKK 183
PLN02200 PLN02200
adenylate kinase family protein
 20-223 3.23e-56

adenylate kinase family protein


Pssm-ID: 215125 [Multi-domain]  Cd Length: 234  Bit Score: 178.93  E-value: 3.23e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043752   20 LTRGLRFFPLQLMKPLVVFVLGGPGAGKGTQCARIVEKYGYTHLSAGELLRDERKNpDSQYGELIEKYIKEGKIVPVEIT 99
Cdd:PLN02200  29 ITLEERGSSSKEKTPFITFVLGGPGSGKGTQCEKIVETFGFKHLSAGDLLRREIAS-NSEHGAMILNTIKEGKIVPSEVT 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043752  100 ISLLKREMDqtmaaNAQKNKFLIDGFPRNQDNLQGWNKTMdgKADVSFVLFFDCNNEICIDRCLERGKssGRSDDNRESL 179
Cdd:PLN02200 108 VKLIQKEME-----SSDNNKFLIDGFPRTEENRIAFERII--GAEPNVVLFFDCPEEEMVKRVLNRNQ--GRVDDNIDTI 178

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 71043752  180 EKRIQTYLESTKPIIDLYEEMGKVKKIDASKSVDEVFGDVMKIF 223
Cdd:PLN02200 179 KKRLKVFNALNLPVIDYYSKKGKLYTINAVGTVDEIFEQVRPIF 222
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 40-222 1.72e-50

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 163.37  E-value: 1.72e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043752  40 LGGPGAGKGTQCARIVEKYGYTHLSAGELLRDERKNpDSQYGELIEKYIKEGKIVPVEITISLLKREMDQtmaaNAQKNK 119
Cdd:COG0563   6 LGPPGAGKGTQAKRLAEKYGIPHISTGDMLRAAVKA-GTELGKKAKEYMDAGELVPDEIVIGLVKERLAQ----PDCANG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043752 120 FLIDGFPRN--Q-DNLQGWNKTMDGKADVsfVLFFDCNNEICIDRCLER---------------------------GKSS 169
Cdd:COG0563  81 FILDGFPRTvaQaEALDELLAELGIKLDA--VIELDVDDEELVERLSGRrvcpncgatyhvkfnppkvegvcdkcgGELV 158

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 71043752 170 GRSDDNRESLEKRIQTYLESTKPIIDLYEEMGKVKKIDASKSVDEVFGDVMKI 222
Cdd:COG0563 159 QRADDNEETVRKRLEVYHEQTAPLIDYYRKKGKLVEIDGEGSIEEVTADILAI 211
 
Name Accession Description Interval E-value
UMP_CMP_kin_fam TIGR01359
UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of ...
 36-224 1.61e-105

UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of UMP-CMP kinase, as well as others proteins with unknown specificity, some currently designated adenylate kinase. All known members are eukaryotic.


Pssm-ID: 273576 [Multi-domain]  Cd Length: 185  Bit Score: 301.98  E-value: 1.61e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043752    36 VVFVLGGPGAGKGTQCARIVEKYGYTHLSAGELLRDERKNPDSQYGELIEKYIKEGKIVPVEITISLLKREMDqtmaANA 115
Cdd:TIGR01359   1 VVFVLGGPGSGKGTQCAKIVENFGFTHLSAGDLLRAEIKREGSENGSLIESYIKEGKIVPSEVTVELLKKAIQ----EDG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043752   116 QKNKFLIDGFPRNQDNLQGWNKTMDGKADVSFVLFFDCNNEICIDRCLERGKSSGRSDDNRESLEKRIQTYLESTKPIID 195
Cdd:TIGR01359  77 SSKKFLIDGFPRNEENLEAWEKLMDNKVNFKFVLFFDCPEETMIKRLLKRGQTSGRVDDNIETLKKRFRTYNEETLPIIE 156

                         170       180
                  ....*....|....*....|....*....
gi 71043752   196 LYEEMGKVKKIDASKSVDEVFGDVMKIFD 224
Cdd:TIGR01359 157 HFENKGKVKEINAEGSVEEVFEDVEKIFA 185
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 36-215 2.59e-69

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 210.56  E-value: 2.59e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043752  36 VVFVLGGPGAGKGTQCARIVEKYGYTHLSAGELLRDERKNpDSQYGELIEKYIKEGKIVPVEITISLLKREMDQtmaaNA 115
Cdd:cd01428   1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIAS-GTELGKKAKEYIDSGKLVPDEIVIKLLKERLKK----PD 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043752 116 QKNKFLIDGFPRNQDNLQGWNKTMDGKADVSFVLFFDCNNEICIDRCLERGKS-------------------SGRSDDNR 176
Cdd:cd01428  76 CKKGFILDGFPRTVDQAEALDELLDEGIKPDKVIELDVPDEVLIERILGRRICpvsgrvyhlgkddvtgeplSQRSDDNE 155

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 71043752 177 ESLEKRIQTYLESTKPIIDLYEEMGKVKKIDASKSVDEV 215
Cdd:cd01428 156 ETIKKRLEVYKEQTAPLIDYYKKKGKLVEIDGSGDIDEV 194
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 36-225 9.69e-62

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 191.18  E-value: 9.69e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043752    36 VVFVLGGPGAGKGTQCARIVEKYGYTHLSAGELLRDERKNpDSQYGELIEKYIKEGKIVPVEITISLLKremdQTMAANA 115
Cdd:TIGR01360   5 IIFIVGGPGSGKGTQCEKIVEKYGFTHLSTGDLLRAEVAS-GSERGKQLQAIMESGDLVPLDTVLDLLK----DAMVAAL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043752   116 QKNK-FLIDGFPRNQDNLQGWNKTMdgkADVSFVLFFDCNNEICIDRCLERGKSSGRSDDNRESLEKRIQTYLESTKPII 194
Cdd:TIGR01360  80 GTSKgFLIDGYPREVKQGEEFERRI---GPPTLVLYFDCSEDTMVKRLLKRAETSGRVDDNEKTIKKRLETYYKATEPVI 156

                         170       180       190
                  ....*....|....*....|....*....|.
gi 71043752   195 DLYEEMGKVKKIDASKSVDEVFGDVMKIFDK 225
Cdd:TIGR01360 157 AYYETKGKLRKINAEGTVDDVFLQVCTAIDK 187
ADK pfam00406
Adenylate kinase;
39-199 2.72e-56

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 177.12  E-value: 2.72e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043752    39 VLGGPGAGKGTQCARIVEKYGYTHLSAGELLRDERKNpDSQYGELIEKYIKEGKIVPVEITISLLKREMDQtmaaNAQKN 118
Cdd:pfam00406   1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKS-GTELGKEAKEYMDKGELVPDEVVVGLVKERLEQ----NDCKN 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043752   119 KFLIDGFPRNQDNLQGWNKTMDGKADVSFVLFFDCNNEICIDRCLERGKS---------------------------SGR 171
Cdd:pfam00406  76 GFLLDGFPRTVPQAEALEELLERGIKLDYVIEFDVPDEVLVERLTGRRIHpnsgrsyhlefnppkvpgkddvtgeplVQR 155

                         170       180
                  ....*....|....*....|....*...
gi 71043752   172 SDDNRESLEKRIQTYLESTKPIIDLYEE 199
Cdd:pfam00406 156 SDDNEETVKKRLETYHKQTKPLIDYYKK 183
PLN02200 PLN02200
adenylate kinase family protein
 20-223 3.23e-56

adenylate kinase family protein


Pssm-ID: 215125 [Multi-domain]  Cd Length: 234  Bit Score: 178.93  E-value: 3.23e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043752   20 LTRGLRFFPLQLMKPLVVFVLGGPGAGKGTQCARIVEKYGYTHLSAGELLRDERKNpDSQYGELIEKYIKEGKIVPVEIT 99
Cdd:PLN02200  29 ITLEERGSSSKEKTPFITFVLGGPGSGKGTQCEKIVETFGFKHLSAGDLLRREIAS-NSEHGAMILNTIKEGKIVPSEVT 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043752  100 ISLLKREMDqtmaaNAQKNKFLIDGFPRNQDNLQGWNKTMdgKADVSFVLFFDCNNEICIDRCLERGKssGRSDDNRESL 179
Cdd:PLN02200 108 VKLIQKEME-----SSDNNKFLIDGFPRTEENRIAFERII--GAEPNVVLFFDCPEEEMVKRVLNRNQ--GRVDDNIDTI 178

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 71043752  180 EKRIQTYLESTKPIIDLYEEMGKVKKIDASKSVDEVFGDVMKIF 223
Cdd:PLN02200 179 KKRLKVFNALNLPVIDYYSKKGKLYTINAVGTVDEIFEQVRPIF 222
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 40-222 1.72e-50

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 163.37  E-value: 1.72e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043752  40 LGGPGAGKGTQCARIVEKYGYTHLSAGELLRDERKNpDSQYGELIEKYIKEGKIVPVEITISLLKREMDQtmaaNAQKNK 119
Cdd:COG0563   6 LGPPGAGKGTQAKRLAEKYGIPHISTGDMLRAAVKA-GTELGKKAKEYMDAGELVPDEIVIGLVKERLAQ----PDCANG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043752 120 FLIDGFPRN--Q-DNLQGWNKTMDGKADVsfVLFFDCNNEICIDRCLER---------------------------GKSS 169
Cdd:COG0563  81 FILDGFPRTvaQaEALDELLAELGIKLDA--VIELDVDDEELVERLSGRrvcpncgatyhvkfnppkvegvcdkcgGELV 158

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 71043752 170 GRSDDNRESLEKRIQTYLESTKPIIDLYEEMGKVKKIDASKSVDEVFGDVMKI 222
Cdd:COG0563 159 QRADDNEETVRKRLEVYHEQTAPLIDYYRKKGKLVEIDGEGSIEEVTADILAI 211
adk PRK00279
adenylate kinase; Reviewed
 40-225 2.89e-48

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 157.62  E-value: 2.89e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043752   40 LGGPGAGKGTQCARIVEKYGYTHLSAGELLRDERKNpDSQYGELIEKYIKEGKIVPVEITISLLKREMDQTMAANAqknk 119
Cdd:PRK00279   6 LGPPGAGKGTQAKFIAEKYGIPHISTGDMLRAAVKA-GTELGKEAKSYMDAGELVPDEIVIGLVKERLAQPDCKNG---- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043752  120 FLIDGFPRN-------QDNLQGWNKTMDGkadvsfVLFFDCNNEICIDR------CLERGKS------------------ 168
Cdd:PRK00279  81 FLLDGFPRTipqaealDEMLKELGIKLDA------VIEIDVPDEELVERlsgrriCPACGRTyhvkfnppkvegkcdvcg 154

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043752  169 ---SGRSDDNRESLEKRIQTYLESTKPIIDLYEEMGKVKKIDASKSVDEVFGDVMKIFDK 225
Cdd:PRK00279 155 eelIQRADDNEETVRKRLEVYHKQTAPLIDYYKKKGKLKKIDGTGSIDEVFADILKALGK 214
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 36-224 2.70e-46

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 152.39  E-value: 2.70e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043752    36 VVFvLGGPGAGKGTQCARIVEKYGYTHLSAGELLRDERKNpDSQYGELIEKYIKEGKIVPVEITISLLKREMDQTMAANa 115
Cdd:TIGR01351   2 LVL-LGPPGSGKGTQAKRIAEKYGLPHISTGDLLRAEIKA-GTPLGKKAKEYMEKGELVPDEIVNQLVKERLTQNDDNE- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043752   116 qkNKFLIDGFPRNQDNLQGWNKTMDGKADVsfVLFFDCNNEICIDRCLERG--KSSG----------------------- 170
Cdd:TIGR01351  79 --NGFILDGFPRTLSQAEALDALLEEPIDA--VIELDVPDEELVERLSGRRicPSCGrvyhlkfnppkvpgcddctgell 154

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 71043752   171 --RSDDNRESLEKRIQTYLESTKPIIDLYEEMGKVKKIDASKSVDEVFGDVMKIFD 224
Cdd:TIGR01351 155 vqREDDTEEVVKKRLEVYKEQTEPLIDYYKKRGILVQIDGNGPIDEVWKRILEALK 210
PRK14527 PRK14527
adenylate kinase; Provisional
 29-221 5.54e-40

adenylate kinase; Provisional


Pssm-ID: 237745 [Multi-domain]  Cd Length: 191  Bit Score: 135.69  E-value: 5.54e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043752   29 LQLMKPLVVFVLGGPGAGKGTQCARIVEKYGYTHLSAGELLRDERKNpDSQYGELIEKYIKEGKIVPVEITISLLKREMd 108
Cdd:PRK14527   1 MTQTKNKVVIFLGPPGAGKGTQAERLAQELGLKKLSTGDILRDHVAR-GTELGQRAKPIMEAGDLVPDELILALIRDEL- 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043752  109 qtmaANAQKNKFLIDGFPRNQDNLQGWNKTM-DGKADVSFVLFFDCNNEICIDRCLERGKSSGRSDDNRESLEKRIQTYL 187
Cdd:PRK14527  79 ----AGMEPVRVIFDGFPRTLAQAEALDRLLeELGARLLAVVLLEVPDEELIRRIVERARQEGRSDDNEETVRRRQQVYR 154

                        170       180       190
                 ....*....|....*....|....*....|....
gi 71043752  188 ESTKPIIDLYEEMGKVKKIDASKSVDEVFGDVMK 221
Cdd:PRK14527 155 EQTQPLVDYYEARGHLKRVDGLGTPDEVYARILK 188
AAA_17 pfam13207
AAA domain;
40-180 5.74e-39

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 131.21  E-value: 5.74e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043752    40 LGGPGAGKGTQCARIVEKYGYTHLSAGELLRDERKnpdSQYGELIEKYIKEGKIVPVEITIsllkREMDQTMAANAQKNK 119
Cdd:pfam13207   1 TGVPGSGKTTQLKKLAEKLGFPHISAGDLLREEAK---ERGLVEDRDEMRKLPLEPQKELQ----KLAAERIAEEAGEGG 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 71043752   120 FLIDGFPR---NQDNLQGWNKTMDGKADVSFVLFFDCNNEICIDRCLERgKSSGRSDDNRESLE 180
Cdd:pfam13207  74 VIVDGHPRiktPAGYLPGLPVEVLRELKPDAIILLEADPEEILERRLKD-RTRGRDDDSEEEIR 136
PRK14532 PRK14532
adenylate kinase; Provisional
 35-215 1.49e-32

adenylate kinase; Provisional


Pssm-ID: 184729 [Multi-domain]  Cd Length: 188  Bit Score: 116.46  E-value: 1.49e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043752   35 LVVFvlGGPGAGKGTQCARIVEKYGYTHLSAGELLRDERKNpDSQYGELIEKYIKEGKIVPVEITISLLKREMDQTMAAN 114
Cdd:PRK14532   3 LILF--GPPAAGKGTQAKRLVEERGMVQLSTGDMLRAAIAS-GSELGQRVKGIMDRGELVSDEIVIALIEERLPEAEAAG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043752  115 AqknkFLIDGFPRNQDNLQGWNKTMDGK-ADVSFVLFFDCNNEICIDRCLERGKSSGRSDDNRESLEKRIQTYLESTKPI 193
Cdd:PRK14532  80 G----AIFDGFPRTVAQAEALDKMLASRgQKIDVVIRLKVDDEALIERIVKRFEEQGRPDDNPEVFVTRLDAYNAQTAPL 155

                        170       180
                 ....*....|....*....|..
gi 71043752  194 IDLYEEMGKVKKIDASKSVDEV 215
Cdd:PRK14532 156 LPYYAGQGKLTEVDGMGSIEAV 177
adk PRK02496
adenylate kinase; Provisional
 40-215 5.05e-31

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 112.54  E-value: 5.05e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043752   40 LGGPGAGKGTQCARIVEKYGYTHLSAGELLRDERKNpDSQYGELIEKYIKEGKIVPVEITISLLKREMDQTMAANAqknk 119
Cdd:PRK02496   7 LGPPGAGKGTQAVVLAEHLHIPHISTGDILRQAIKE-QTPLGIKAQGYMDKGELVPDQLVLDLVQERLQQPDAANG---- 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043752  120 FLIDGFPRNQDNLQGWNKTMDGKAD-VSFVLFFDCNNEICIDRCLERGkssgRSDDNRESLEKRIQTYLESTKPIIDLYE 198
Cdd:PRK02496  82 WILDGFPRKVTQAAFLDELLQEIGQsGERVVNLDVPDDVVVERLLARG----RKDDTEEVIRRRLEVYREQTAPLIDYYR 157

                        170
                 ....*....|....*..
gi 71043752  199 EMGKVKKIDASKSVDEV 215
Cdd:PRK02496 158 DRQKLLTIDGNQSVEAV 174
PRK14531 PRK14531
adenylate kinase; Provisional
 32-215 2.56e-30

adenylate kinase; Provisional


Pssm-ID: 172997 [Multi-domain]  Cd Length: 183  Bit Score: 110.67  E-value: 2.56e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043752   32 MKPLVVFvLGGPGAGKGTQCARIVEKYGYTHLSAGELLRDERKnPDSQYGELIEKYIKEGKIVPVEITISLLKREMdqtm 111
Cdd:PRK14531   1 MKQRLLF-LGPPGAGKGTQAARLCAAHGLRHLSTGDLLRSEVA-AGSALGQEAEAVMNRGELVSDALVLAIVESQL---- 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043752  112 aANAQKNKFLIDGFPRNQDNLQGWNKTMDG-KADVSFVLFFDCNNEICIDRCLERgkssGRSDDNRESLEKRIQTYLEST 190
Cdd:PRK14531  75 -KALNSGGWLLDGFPRTVAQAEALEPLLEElKQPIEAVVLLELDDAVLIERLLAR----GRADDNEAVIRNRLEVYREKT 149

                        170       180
                 ....*....|....*....|....*
gi 71043752  191 KPIIDLYEEMGKVKKIDASKSVDEV 215
Cdd:PRK14531 150 APLIDHYRQRGLLQSVEAQGSIEAI 174
PRK14530 PRK14530
adenylate kinase; Provisional
 37-226 5.94e-29

adenylate kinase; Provisional


Pssm-ID: 237747 [Multi-domain]  Cd Length: 215  Bit Score: 107.95  E-value: 5.94e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043752   37 VFVLGGPGAGKGTQCARIVEKYGYTHLSAGELLRDERKNP----DSQYGELIEkYIKEGKIVPVEITISLLKremdqtmA 112
Cdd:PRK14530   6 ILLLGAPGAGKGTQSSNLAEEFGVEHVTTGDALRANKQMDisdmDTEYDTPGE-YMDAGELVPDAVVNEIVE-------E 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043752  113 ANAQKNKFLIDGFPRNQDNLQgwnkTMDGKADVSFVLFFDCNNEICIDR------CLERGKS------------------ 168
Cdd:PRK14530  78 ALSDADGFVLDGYPRNLEQAE----YLESITDLDVVLYLDVSEEELVDRltgrrvCPDCGANyhvefnqpeeegvcdecg 153

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 71043752  169 ---SGRSDDNRESLEKRIQTYLESTKPIIDLYEEMGKVKKIDASKSVDEVFGDVMKIFDKE 226
Cdd:PRK14530 154 gelIQRDDDTEETVRERLDVFEENTEPVIEHYRDQGVLVEVDGEQTPDEVWADIQDAIDDA 214
PRK14528 PRK14528
adenylate kinase; Provisional
 32-221 1.05e-28

adenylate kinase; Provisional


Pssm-ID: 172994 [Multi-domain]  Cd Length: 186  Bit Score: 106.63  E-value: 1.05e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043752   32 MKPLVVfvLGGPGAGKGTQCARIVEKYGYTHLSAGELLRDERKNpDSQYGELIEKYIKEGKIVPVEITISLLKremDQTM 111
Cdd:PRK14528   1 MKNIIF--MGPPGAGKGTQAKILCERLSIPQISTGDILREAVKN-QTAMGIEAKRYMDAGDLVPDSVVIGIIK---DRIR 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043752  112 AANAqKNKFLIDGFPRNQDNLQGWNKTMDGKA-DVSFVLFFDCNNEICIDRCLERGKSSGRSDDNRESLEKRIQTYLEST 190
Cdd:PRK14528  75 EADC-KNGFLLDGFPRTVEQADALDALLKNEGkSIDKAINLEVPDGELLKRLLGRAEIEGRADDNEATIKNRLDNYNKKT 153

                        170       180       190
                 ....*....|....*....|....*....|.
gi 71043752  191 KPIIDLYEEMGKVKKIDASKSVDEVFGDVMK 221
Cdd:PRK14528 154 LPLLDFYAAQKKLSQVNGVGSLEEVTSLIQK 184
PLN02842 PLN02842
nucleotide kinase
 41-225 3.71e-28

nucleotide kinase


Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 110.72  E-value: 3.71e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043752   41 GGPGAGKGTQCARIVEKYGYTHLSAGELLRDErKNPDSQYGELIEKYIKEGKIVPVEITISLLKREMDQtmaANAQKNKF 120
Cdd:PLN02842   4 GAPASGKGTQCELIVHKFGLVHISTGDLLRAE-VSAGTDIGKRAKEFMNSGRLVPDEIVIAMVTGRLSR---EDAKEKGW 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043752  121 LIDGFPRNQDNLQGWNKtMDGKADVSFVLffDCNNEICIDRCLER-----------------------GKSSGRSDDNRE 177
Cdd:PLN02842  80 LLDGYPRSFAQAQSLEK-LKIRPDIFILL--DVPDEILIDRCVGRrldpvtgkiyhiknfppeseeikARLITRPDDTEE 156

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 71043752  178 SLEKRIQTYLESTKPIIDLYEEMgkVKKIDASKSVDEVFGDVMKIFDK 225
Cdd:PLN02842 157 KVKARLQIYKKNAEAILSTYSDI--MVKIDGNRPKEVVFEEISSLLSQ 202
PRK13808 PRK13808
adenylate kinase; Provisional
 39-224 2.25e-25

adenylate kinase; Provisional


Pssm-ID: 172341 [Multi-domain]  Cd Length: 333  Bit Score: 101.12  E-value: 2.25e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043752   39 VLGGPGAGKGTQCARIVEKYGYTHLSAGELLRDERKnPDSQYGeLIEKYI-KEGKIVPVEITISLLKREMDQTMAANAqk 117
Cdd:PRK13808   5 LLGPPGAGKGTQAQRLVQQYGIVQLSTGDMLRAAVA-AGTPVG-LKAKDImASGGLVPDEVVVGIISDRIEQPDAANG-- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043752  118 nkFLIDGFPRNQDNLQGWNKTM-DGKADVSFVLFFDCNNEICIDRC-------LERGKSSgRSDDNRESLEKRIQTYLES 189
Cdd:PRK13808  81 --FILDGFPRTVPQAEALDALLkDKQLKLDAVVELRVNEGALLARVetrvaemRARGEEV-RADDTPEVLAKRLASYRAQ 157

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 71043752  190 TKPIIDLYEEMGKVKKIDASKSVDEVFGDVMKIFD 224
Cdd:PRK13808 158 TEPLVHYYSEKRKLLTVDGMMTIDEVTREIGRVLA 192
PRK14526 PRK14526
adenylate kinase; Provisional
 40-225 1.08e-24

adenylate kinase; Provisional


Pssm-ID: 172992 [Multi-domain]  Cd Length: 211  Bit Score: 96.84  E-value: 1.08e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043752   40 LGGPGAGKGTQCARIVEKYGYTHLSAGELLRDERKNpDSQYGELIEKYIKEGKIVPVEITISLLKREMDqtmaANAQKNK 119
Cdd:PRK14526   6 LGPPGSGKGTIAKILSNELNYYHISTGDLFRENILN-STPLGKEIKQIVENGQLVPDSITIKIVEDKIN----TIKNNDN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043752  120 FLIDGFPRNQDNLQGWNKTMDGKADVSFVL--------------------FFDC------NNEICiDRCleRGKSSGRSD 173
Cdd:PRK14526  81 FILDGFPRNINQAKALDKFLPNIKIINFLIdeellikrlsgrrickscnnIFNIytlptkEKGIC-DVC--KGDLYQRKD 157

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 71043752  174 DNRESLEKRIQTYLESTKPIIDLYEEMGKVKKIDASKSVDEVFGDVMKIFDK 225
Cdd:PRK14526 158 DKEESLKTRLQEYKLQTKPLIEFYSKCNRLNNIDASKDIDEVKKKLIEIISK 209
PLN02459 PLN02459
probable adenylate kinase
 37-203 4.16e-19

probable adenylate kinase


Pssm-ID: 215253 [Multi-domain]  Cd Length: 261  Bit Score: 82.97  E-value: 4.16e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043752   37 VFvLGGPGAGKGTQCARIVEKYGYTHLSAGELLRDERKNpDSQYGELIEKYIKEGKIVPVEITISLLKREMDQTMAANaq 116
Cdd:PLN02459  33 VF-LGCPGVGKGTYASRLSKLLGVPHIATGDLVREEIKS-SGPLGAQLKEIVNQGKLVPDEIIFSLLSKRLEAGEEEG-- 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043752  117 KNKFLIDGFPRNQDNLQgwnkTMDGKADVSFVLFFDCNNEICIDRCLER------------------------------- 165
Cdd:PLN02459 109 ESGFILDGFPRTVRQAE----ILEGVTDIDLVVNLKLREEVLVEKCLGRricsecgknfnvadidlkgedgrpgivmppl 184

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 71043752  166 -------GKSSGRSDDNRESLEKRIQTYLESTKPIIDLYEEMGKV 203
Cdd:PLN02459 185 lpppecaSKLITRADDTEEVVKARLRVYKEESQPVEDFYRKRGKL 229
PLN02674 PLN02674
adenylate kinase
 14-222 2.34e-17

adenylate kinase


Pssm-ID: 178279 [Multi-domain]  Cd Length: 244  Bit Score: 78.00  E-value: 2.34e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043752   14 VPSFPPLTRGLRFFPLQLMKPLVVFVLGGPGAGKGTQCARIVEKYGYTHLSAGELLRDE--RKNPdsqYGELIEKYIKEG 91
Cdd:PLN02674  11 VPSVDLMTELLRRMKCSSKPDKRLILIGPPGSGKGTQSPIIKDEYCLCHLATGDMLRAAvaAKTP---LGIKAKEAMDKG 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043752   92 KIVPVEITISLlkreMDQTMAANAQKNKFLIDGFPRNQDNLQGWNKTMDGK-ADVSFVLFFDCNNEICIDRCLER--GKS 168
Cdd:PLN02674  88 ELVSDDLVVGI----IDEAMKKPSCQKGFILDGFPRTVVQAQKLDEMLAKQgAKIDKVLNFAIDDAILEERITGRwiHPS 163

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 71043752  169 SGRS-------------------------DDNRESLEKRIQTYLESTKPIIDLYEEMGKVKKIDASKSVDEVFGDVMKI 222
Cdd:PLN02674 164 SGRTyhtkfappkvpgvddvtgepliqrkDDTAAVLKSRLEAFHKQTEPVIDYYAKKGVVANLHAEKPPKEVTAEVQKA 242
PTZ00088 PTZ00088
adenylate kinase 1; Provisional
 29-201 4.83e-15

adenylate kinase 1; Provisional


Pssm-ID: 240262 [Multi-domain]  Cd Length: 229  Bit Score: 71.37  E-value: 4.83e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043752   29 LQLMKPLVVFVLGGPGAGKGTQCARIVEKYGYTHLSAGELLRDERKNpDSQYGELIEKYIKEGKIVPVEITISLLKREMD 108
Cdd:PTZ00088   1 MKLKGPLKIVLFGAPGVGKGTFAEILSKKENLKHINMGNILREEIKA-KTTIGKEIQKVVTSGNLVPDNLVIAIVKDEIA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043752  109 QTMAANAQknKFLIDGFPRN--QDNLQGWNKTMDGKADVSFVLFF------------DCNNEICI--------------- 159
Cdd:PTZ00088  80 KVTDDCFK--GFILDGFPRNlkQCKELGKITNIDLFVNIYLPRNIlikkllgrricnTCNRNFNIahirsdpydmppilp 157

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 71043752  160 ----DRCLERGKSSGRSDDNRESLEKRIQTYLESTKPIIDLYEEMG 201
Cdd:PTZ00088 158 padcEGCKGNPKLQKRSDDTEEIVAHRLNTYESTNSPIIQFFKNEN 203
PRK14529 PRK14529
adenylate kinase; Provisional
 37-171 1.98e-10

adenylate kinase; Provisional


Pssm-ID: 237746 [Multi-domain]  Cd Length: 223  Bit Score: 58.58  E-value: 1.98e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043752   37 VFVLGGPGAGKGTQCARIVEKYGYTHLSAGELLRdERKNPDSQYGELIEKYIKEGKIVPVEITISLLKREMDQtmaanAQ 116
Cdd:PRK14529   3 ILIFGPNGSGKGTQGALVKKKYDLAHIESGAIFR-EHIGGGTELGKKAKEYIDRGDLVPDDITIPMILETLKQ-----DG 76

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 71043752  117 KNKFLIDGFPRNQDNLQG-WNKTMDGKADVSFVLffdcnnEICIDRCLERGKSSGR 171
Cdd:PRK14529  77 KNGWLLDGFPRNKVQAEKlWEALQKEGMKLDYVI------EILLPREVAKNRIMGR 126
Tmk COG0125
Thymidylate kinase [Nucleotide transport and metabolism]; Thymidylate kinase is part of the ...
 32-225 3.12e-08

Thymidylate kinase [Nucleotide transport and metabolism]; Thymidylate kinase is part of the Pathway/BioSystem: Thymidylate biosynthesis


Pssm-ID: 439895 [Multi-domain]  Cd Length: 206  Bit Score: 52.08  E-value: 3.12e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043752  32 MKP-LVVFvLGGPGAGKGTQCARIVEKY-------------GYTHLsaGELLR------DERKNPDS-----------QY 80
Cdd:COG0125   1 MKGkFIVF-EGIDGSGKSTQIKLLAEYLeargydvvltrepGGTPL--GEAIRelllgdNEDMSPRTelllfaadraqHV 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043752  81 GELIEKYIKEGKIVpveitisLLKREMDQTMA----AN-------AQKNKFLIDGFprnqdnlqgwnktmdgKADVsfVL 149
Cdd:COG0125  78 EEVIRPALAAGKIV-------ICDRYVDSSLAyqggGRgldlewiRQLNRFATGGL----------------KPDL--TI 132

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 71043752 150 FFDCNNEICIDRCLERGKSSGRSD-DNRESLEKRIQTYLEstkpIIDLYEEmgKVKKIDASKSVDEVFGDVMKIFDK 225
Cdd:COG0125 133 LLDVPPEVALARARARGGELDRFEsEDLEFHERVREGYLE----LAAKEPE--RIVVIDASQSIEEVHAEIREALAE 203
AAA_18 pfam13238
AAA domain;
37-177 3.70e-06

AAA domain;


Pssm-ID: 433052 [Multi-domain]  Cd Length: 128  Bit Score: 44.73  E-value: 3.70e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043752    37 VFVLGGPGAGKGTQCARIVEKYGYthlsaGELLRDERKnpDSQYGELIEKYIKEGKIVPVEITISLLkREMDQTmAANAQ 116
Cdd:pfam13238   1 ILITGTPGVGKTTLAKELSKRLGF-----GDNVRDLAL--ENGLVLGDDPETRESKRLDEDKLDRLL-DLLEEN-AALEE 71

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 71043752   117 KNKFLIDGFPrnqdnlqGWNKTMDGKADVSFVLffDCNNEICIDRCLERGKSSGRSDDNRE 177
Cdd:pfam13238  72 GGNLIIDGHL-------AELEPERAKDLVGIVL--RASPEELLERLEKRGYEEAKIKENEE 123
TMPK cd01672
Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the ...
 35-225 8.07e-06

Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step in either de novo or salvage biosynthesis of thymidine triphosphate (TTP).


Pssm-ID: 238835  Cd Length: 200  Bit Score: 44.95  E-value: 8.07e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043752  35 LVVFVlGGPGAGKGTQCARIVE---KYGYTHL--------SAGELLR----DERKNPDSQYGEL--------------IE 85
Cdd:cd01672   2 FIVFE-GIDGAGKTTLIELLAErleARGYEVVltrepggtPIGEAIRelllDPEDEKMDPRAELllfaadraqhveevIK 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043752  86 KYIKEGKIVpveitisLLKREMDQTMA---ANAQKNKFLIDGFprNQDNLQGWnktmdgKADVsfVLFFDCNNEICIDRC 162
Cdd:cd01672  81 PALARGKIV-------LSDRFVDSSLAyqgAGRGLGEALIEAL--NDLATGGL------KPDL--TILLDIDPEVGLARI 143

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 71043752 163 LERGKSSGRSDDNRESLEKRIQTYLESTKpiidlyEEMGKVKKIDASKSVDEVFGDVMKIFDK 225
Cdd:cd01672 144 EARGRDDRDEQEGLEFHERVREGYLELAA------QEPERIIVIDASQPLEEVLAEILKAILE 200
PRK04182 PRK04182
cytidylate kinase; Provisional
 35-71 9.29e-05

cytidylate kinase; Provisional


Pssm-ID: 235244 [Multi-domain]  Cd Length: 180  Bit Score: 41.72  E-value: 9.29e-05
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 71043752   35 LVVFVLGGPGAGKGTQCARIVEKYGYTHLSAGELLRD 71
Cdd:PRK04182   1 MIITISGPPGSGKTTVARLLAEKLGLKHVSAGEIFRE 37
CMPK cd02020
Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine ...
 41-68 1.35e-03

Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor.


Pssm-ID: 238978 [Multi-domain]  Cd Length: 147  Bit Score: 37.85  E-value: 1.35e-03
                        10        20
                ....*....|....*....|....*...
gi 71043752  41 GGPGAGKGTQCARIVEKYGYTHLSAGEL 68
Cdd:cd02020   6 GPAGSGKSTVAKLLAKKLGLPYLDTGGI 33
AAA_28 pfam13521
AAA domain;
36-214 2.06e-03

AAA domain;


Pssm-ID: 433278 [Multi-domain]  Cd Length: 164  Bit Score: 37.63  E-value: 2.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043752    36 VVFVlGGPGAGKGTQCARIVEKYGYTHLS--AGELLRDERKNpdsqyGELIEKYIKEgkivPVEITISLLKREMDQtmAA 113
Cdd:pfam13521   2 IVIT-GGPSTGKTTLAEALAARFGYPVVPeaAREILEELGAD-----GGDALPWVED----LLAFARGVLEAQLED--EA 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043752   114 NAQKNKFLIdgFPRNQDNLQGWNKTMDGKADVSF-----------VLFFDCNNEICIDRclERgkssgrsddnRESLEKR 182
Cdd:pfam13521  70 AAAANDLLF--FDRGPLDTLAYSRAYGGPCPPELeaaarasrydlVFLLPPDPEIVQDG--ER----------REDPEER 135

                         170       180       190
                  ....*....|....*....|....*....|..
gi 71043752   183 IQTYLEstkpIIDLYEEMGKVKKIDASKSVDE 214
Cdd:pfam13521 136 ERFHER----LREALRELGIPVIIVPRGSVEE 163
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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