|
Name |
Accession |
Description |
Interval |
E-value |
| Patched |
pfam02460 |
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ... |
66-883 |
0e+00 |
|
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.
Pssm-ID: 308203 [Multi-domain] Cd Length: 793 Bit Score: 585.47 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 66 NDITGYTPYGARARDEFDVMTDFFAHNGNGIAMFVLILPTRHES-VLHPDVLREALRLEDILSTNFSmLSADGKPENYQE 144
Cdd:pfam02460 13 DDARSFTERGVRSEYEPLVENKFFPGDSYPEARFLIITAKGRNSnILDISYLNDIYQLNDYISTNVE-IQVDGIIISFKD 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 145 FCTNFCQINEPFVQFARSYLTELDNSKngtdlseRISLNYPITSIYSRKMSIQPNFFGIEMMNETkksitNIRSSKLIAL 224
Cdd:pfam02460 92 LCSRYCDLNCPVNKHYNGMLLSRRHNT-------RIDITYPIMPVLGTPIYLGPHFGGVDFEPPG-----NISYAKAIVL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 225 QLRSERKEGWNSNGIKDFEMSITNYLEKEFESPEIRVLTLSTSYVEAEVVRAGMSLLPFLIVGFVIMAIVSSVTTFFSAV 304
Cdd:pfam02460 160 WYFLKFDEEEVEEDSKEWEDELSQLLHNKYASEHIQFTIFHDQILNDELVRNALTLTPFFVIGFFLLLTFSIIVSVTLSS 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 305 YMQQVSIHKFSLAIAACICPFMACGTALGALFFCGVRFGSILCVTPFLVLAIGVDDAYLMIHSWQRVTAERRKHpvands 384
Cdd:pfam02460 240 YTIDWVRSKPILAALGLLSPVMAIVSSFGLLFWMGFPFNSIVCVTPFLVLAIGVDDMFLMVAAWQRTTATLSVK------ 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 385 pgSRLSEVLVDTGPAILISALTNIFADVAGCFTSSPEISLLGYGNMACIFCDFLYQITFYSAIMTLTGYFEMKdeeqKRH 464
Cdd:pfam02460 314 --KRMGEALSEAGVSITITSLTDVLSFGIGTYTPTPAIQLFCAYTAVAIFFDFIYQITFFAAIMAICAKPEAE----GRH 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 465 IKKIACGADSDDSSCTSSSVESFDVIVKRRVTSFLENYISLITNAFFQIFVVLVWIAFLVVSIYGITIMNINLSPRKLFM 544
Cdd:pfam02460 388 CLFVWATSSPQRIDSEGSEPDKSHNIEQLKSRFFLDIYCPFLLNPSVRVCMLVLFVVYIAIAIYGCVNIKEGLEPDKLVL 467
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 545 EDSSLREMDDLRVKYVIPNFYLANVFVRKPGDLTDGARLQRLNQFVEEMEHLNGSWGSLGTNYFVRDFVNFQAAMVEEEE 624
Cdd:pfam02460 468 EDSPLVEYLSLREKHFWPEGLQIQVAVNNPPNLTIPESRDRMNEMVDEFENTPYSLGPNSTLFWLREYENFLSTLNMEEE 547
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 625 AeggeeeasiVKRGGIDVNNLPMFLEWPEYLFWKGFVQFhsAENRTVLDRFFITFAIHgtNLQSWPARGDALREWRNVVD 704
Cdd:pfam02460 548 E---------DEEKEWSYGNLPSFLKAPGNSHWAGDLVW--DDNTTMVTKFRFTLAGK--GLSTWNDRTRALQEWRSIAD 614
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 705 KYSaEFGLSVFSDDGIYVDLIENMPTDAWQSAVATLACMAFICFVFMYDVPTVMVATSIIASIMTGILGILSLTGTDLDP 784
Cdd:pfam02460 615 QYP-EFNVTVFDEDAPFADQYLTILPSTIQNIVITLICMFIVCFLFIPNPPCVFVITLAIASIDIGVFGFLSLWGVDLDP 693
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 785 IVMSALIISIGFSVDIPAHISYHYHTSPSDNgIRHRLHKTLSSVGFPALQATVSTSLCVLSLKFSSIYMSCAFVKTMITC 864
Cdd:pfam02460 694 ISMITIIMSIGFSVDFSAHIAYHFVRSRGDT-PAERVVDALEALGWPVFQGGLSTILGVLVLLFVPSYMVVVFFKTVFLV 772
|
810
....*....|....*....
gi 115532069 865 MILCVFHALVLLPCLFAIF 883
Cdd:pfam02460 773 VAIGLLHGLFILPIILSLF 791
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
28-886 |
9.86e-27 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 117.27 E-value: 9.86e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 28 WFFEKWSHFVADHAVALIVICVVLTLIGTFKVATTPNDNDITGYTPYGARARDEFDVMTDFFahnGNGIAMFVLIlpTRH 107
Cdd:COG1033 2 RLMERLARFILRHRKLVLLLFLLLTLLLAYGAPKLEVDTDFESLLPEDDPSVQAYDEFEEEF---GGDDTVVVAV--EGK 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 108 ESVLHPDVLREALRLEDILSTNfsmlsadgkpenyqefctnfcqinePFVQFARSYLT--ELDNSKNGTDLSERISLNYP 185
Cdd:COG1033 77 DDIFTPETLEALRELTEELEEI-------------------------PGVDSVTSLTNvrATEGTEDGLTVEPLIPDELP 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 186 IT--SIYSRKMSIQPNFFGIEMMNETKKSITnirsskLIALQLRSERKEGwnsngiKDFEMSITNYLEK---EFESPEIR 260
Cdd:COG1033 132 ASpeELAELREKVLSSPLYVGRLVSPDGKAT------LIVVTLDPDPLSS------DLDRKEVVAEIRAiiaKYEDPGVE 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 261 VLTLSTSYVEAEVVRAGMS-LLPFLIVGFVIMAIVSSVTTffsavymqqvsiHKFSLAIAACICPFMACGTALGALFFCG 339
Cdd:COG1033 200 VYLTGFPVLRGDIAEAIQSdLAIFFPLALLLILLLLFLFF------------RSLRGVLLPLLVVLLAVIWTLGLMGLLG 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 340 VRFGSILCVTPFLVLAIGVDDAylmIHSWQRVTAERRKHpvanDSPGSRLSEVLVDTGPAILISALTNIFADVAGCFTSS 419
Cdd:COG1033 268 IPLSPLTILVPPLLLAIGIDYG---IHLLNRYREERRKG----LDKREALREALRKLGPPVLLTSLTTAIGFLSLLFSDI 340
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 420 PEISLLGYGNMACIFCDFLYQITFYSAIMTltgYFEMKDEEQKRHIKKIACGADSDDSSctsssvesfDVIVKRRVTsfl 499
Cdd:COG1033 341 PPIRDFGIVAAIGVLLAFLTSLTLLPALLS---LLPRPKPKTRRLKKPPELGRLLAKLA---------RFVLRRPKV--- 405
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 500 enyislitnaffqifVVLVWIAFLVVSIYGITIMNINLSPRKLFMEDSSLREMDDLrVKYVIPNFYLANVFVR--KPGDL 577
Cdd:COG1033 406 ---------------ILVVALVLAVVSLYGISRLKVEYDFEDYLPEDSPIRQDLDF-IEENFGGSDPLEVVVDtgEPDGL 469
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 578 TDGARLQRLNQFVEEMEHLNGSWGSLGTNYFVRDFvnfqaamveeeeaeggeeeASIVKRGGIDVNNLP-------MFLE 650
Cdd:COG1033 470 KDPEVLKEIDRLQDYLESLPEVGKVLSLADLVKEL-------------------NQALNEGDPKYYALPesrellaQLLL 530
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 651 WPEYLFWKGFVQFHSAENRTVldRFFITFAIHGTNlqswpARGDALREWRNVVDKYSAEFGLSVF--SDDGIYVDLIENM 728
Cdd:COG1033 531 LLSSPPGDDLSRFVDEDYSAA--RVTVRLKDLDSE-----EIKALVEEVRAFLAENFPPDGVEVTltGSAVLFAAINESV 603
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 729 PTDAWQSAVATLACMAFICFVFMYDVptVMVATSIIASIMT--GILGILSLTGTDLDPIVMSALIISIGFSVDIPAHISY 806
Cdd:COG1033 604 IESQIRSLLLALLLIFLLLLLAFRSL--RLGLISLIPNLLPilLTFGLMGLLGIPLNIATAVVASIALGIGVDYTIHFLS 681
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 807 HY-HTSPSDNGIRHRLHKTLSSVGFPALQATVSTSLCVLSLKFSSIYMSCAFVKTMITCMILCVFHALVLLPCLFAIFHR 885
Cdd:COG1033 682 RYrEERRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLLLPALLLLLDP 761
|
.
gi 115532069 886 I 886
Cdd:COG1033 762 R 762
|
|
| 2A060601 |
TIGR00917 |
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ... |
29-883 |
3.49e-21 |
|
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]
Pssm-ID: 273337 [Multi-domain] Cd Length: 1205 Bit Score: 99.98 E-value: 3.49e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 29 FFEKWSHFVADHAVALIVICVVLTL---IGTFKVATTPNDNDItgYTPYGARARDE---FDV-MTDFFAHNGNGIAMFVL 101
Cdd:TIGR00917 312 FFGKYGIWVARHPTLVICLSVSVVLllcVGLIRFKVETRPVKL--WVAPGSRAALEkqyFDThFGPFYRIEQLIIATVQT 389
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 102 ILPTRHESVLHPDVLREALRLEDILSTNFSmlSADGKPENYQEFCTnfcQINEPFVQFARSYLTELDNS------KNGTD 175
Cdd:TIGR00917 390 SSHEKAPEILTDDNLKLLFDIQKKVSQLFA--NYEGELITLDSPCF---KPNHPYNCFIYSTCKKLQNMysklkpENYDD 464
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 176 --LSERI-----SLNYPITSIYSRKMSIQPNFF--GIEMMNetkksiTNIRSSKLIALQLRSERKEGWNSNGIKDFEMSI 246
Cdd:TIGR00917 465 ygGVDYVkycfeHFTSPESCLSAFGGPVDPTTVlgGFSGNN------FSEASAFVVTFPVNNFVNKTNKTEKAVAWEKAF 538
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 247 TNYLEKEFESPEIRVLTLST-SYVEAEVVRAGMSLLPFLIVGFVIMAIVSSVTTFFSAVYMQQVSIHKFSLAIAACICPF 325
Cdd:TIGR00917 539 IQLAKDELLPMVQATISFSAeRSIEDELKRESTADVITIAISYLVMFAYISLTLGDSPRLKSLYVTSKVLLGLSGILIVM 618
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 326 MACGTALGALFFCGVRFGSILC-VTPFLVLAIGVDDAYLMIHSWQRVTAERRKHPVANDSPGS---RLSEVLVDTGPAIL 401
Cdd:TIGR00917 619 LSVLGSVGVFSAVGLKSTLIIMeVIPFLVLAVGVDNIFILVFFYFYLEYFYRQVGVDNEQELTlerRLSRALMEVGPSIT 698
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 402 ISALTNIFADVAGCFTSSPEISLLGYGNMACIFCDFLYQITFYSAIMTltgyFEMKDEEQKRhIKKIACGADSDDSSCTS 481
Cdd:TIGR00917 699 LASLSEILAFALGALIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLV----LDFKRTEDKR-VDCFPCIKTSKSSISAE 773
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 482 SSVESFDVIVKRRVtsFLENYISLITNAFFQIFVVLVWIAFLVVSIYGITIMNINLSPRKLFMEDSSLREMDDLRVKY-- 559
Cdd:TIGR00917 774 KGSGQRKAGLLTRY--FKEVYAPVLLHWIVKIVVIAFFVGLLMAGIALSTRVEIGLDQQIVLPQDSYLQIYFASLTPLle 851
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 560 VIPNFYlanvFVRKPG-DLTD-----------GARLQRLNQFVEEMEHLNGSWGSLGTNYFV----------RDFVNFQA 617
Cdd:TIGR00917 852 VGPPFY----IVIKGDyNYTDfesqnklctmgGCDKDSIVNVFNNLSYIAKPASSWLDDYLVwlspqascccRKFTNGTF 927
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 618 AMVEEEEAEGGEEEASIVKR---GGIDVNNLPMFL-EWPEYLFWKGFVQFHSAENRTVLDRFFI---TFAIHGTNLQSWP 690
Cdd:TIGR00917 928 CNGPDPQCFRCADLSSDAQGrpsTTQFKEKLPWFLnALPSADCAKGGHAAYSSAVDLQGYATIIqasSFRTYHTPLNTQV 1007
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 691 ARGDALREWRNVVDKYSAEFGLSVFSDDGIYV--DLIENMPTDAWQSAVATLACMAFICFVFMYDVPTVMVATSI-IASI 767
Cdd:TIGR00917 1008 DFINAMRAAQEFAAKVSRSSKMEVYPYSVFYVffEQYLTIWKTAIINLSIALGAIFIVCLFLLQLNALSVVNLIMsVGMA 1087
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 768 MTGILGILSLTGTDLDPIVMSALIISIGFSVDIPAHISYHYHTSPSDNGIrHRLHKTLSSVG---FPALQATVSTSLCVL 844
Cdd:TIGR00917 1088 VVFCVGIMHLWSISLNAVSVVNSVMHKGIAIEFCTHINAQFSTGKHFSRN-HRAKEALGGMGssvFSGITLTKLVGVVVL 1166
|
890 900 910
....*....|....*....|....*....|....*....
gi 115532069 845 SLKFSSIYMSCAFvKTMITCMILCVFHALVLLPCLFAIF 883
Cdd:TIGR00917 1167 GFSRSEIFVVYYF-RMYLALVLLGFLHGLVFLPVLLSVL 1204
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Patched |
pfam02460 |
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ... |
66-883 |
0e+00 |
|
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.
Pssm-ID: 308203 [Multi-domain] Cd Length: 793 Bit Score: 585.47 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 66 NDITGYTPYGARARDEFDVMTDFFAHNGNGIAMFVLILPTRHES-VLHPDVLREALRLEDILSTNFSmLSADGKPENYQE 144
Cdd:pfam02460 13 DDARSFTERGVRSEYEPLVENKFFPGDSYPEARFLIITAKGRNSnILDISYLNDIYQLNDYISTNVE-IQVDGIIISFKD 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 145 FCTNFCQINEPFVQFARSYLTELDNSKngtdlseRISLNYPITSIYSRKMSIQPNFFGIEMMNETkksitNIRSSKLIAL 224
Cdd:pfam02460 92 LCSRYCDLNCPVNKHYNGMLLSRRHNT-------RIDITYPIMPVLGTPIYLGPHFGGVDFEPPG-----NISYAKAIVL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 225 QLRSERKEGWNSNGIKDFEMSITNYLEKEFESPEIRVLTLSTSYVEAEVVRAGMSLLPFLIVGFVIMAIVSSVTTFFSAV 304
Cdd:pfam02460 160 WYFLKFDEEEVEEDSKEWEDELSQLLHNKYASEHIQFTIFHDQILNDELVRNALTLTPFFVIGFFLLLTFSIIVSVTLSS 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 305 YMQQVSIHKFSLAIAACICPFMACGTALGALFFCGVRFGSILCVTPFLVLAIGVDDAYLMIHSWQRVTAERRKHpvands 384
Cdd:pfam02460 240 YTIDWVRSKPILAALGLLSPVMAIVSSFGLLFWMGFPFNSIVCVTPFLVLAIGVDDMFLMVAAWQRTTATLSVK------ 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 385 pgSRLSEVLVDTGPAILISALTNIFADVAGCFTSSPEISLLGYGNMACIFCDFLYQITFYSAIMTLTGYFEMKdeeqKRH 464
Cdd:pfam02460 314 --KRMGEALSEAGVSITITSLTDVLSFGIGTYTPTPAIQLFCAYTAVAIFFDFIYQITFFAAIMAICAKPEAE----GRH 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 465 IKKIACGADSDDSSCTSSSVESFDVIVKRRVTSFLENYISLITNAFFQIFVVLVWIAFLVVSIYGITIMNINLSPRKLFM 544
Cdd:pfam02460 388 CLFVWATSSPQRIDSEGSEPDKSHNIEQLKSRFFLDIYCPFLLNPSVRVCMLVLFVVYIAIAIYGCVNIKEGLEPDKLVL 467
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 545 EDSSLREMDDLRVKYVIPNFYLANVFVRKPGDLTDGARLQRLNQFVEEMEHLNGSWGSLGTNYFVRDFVNFQAAMVEEEE 624
Cdd:pfam02460 468 EDSPLVEYLSLREKHFWPEGLQIQVAVNNPPNLTIPESRDRMNEMVDEFENTPYSLGPNSTLFWLREYENFLSTLNMEEE 547
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 625 AeggeeeasiVKRGGIDVNNLPMFLEWPEYLFWKGFVQFhsAENRTVLDRFFITFAIHgtNLQSWPARGDALREWRNVVD 704
Cdd:pfam02460 548 E---------DEEKEWSYGNLPSFLKAPGNSHWAGDLVW--DDNTTMVTKFRFTLAGK--GLSTWNDRTRALQEWRSIAD 614
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 705 KYSaEFGLSVFSDDGIYVDLIENMPTDAWQSAVATLACMAFICFVFMYDVPTVMVATSIIASIMTGILGILSLTGTDLDP 784
Cdd:pfam02460 615 QYP-EFNVTVFDEDAPFADQYLTILPSTIQNIVITLICMFIVCFLFIPNPPCVFVITLAIASIDIGVFGFLSLWGVDLDP 693
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 785 IVMSALIISIGFSVDIPAHISYHYHTSPSDNgIRHRLHKTLSSVGFPALQATVSTSLCVLSLKFSSIYMSCAFVKTMITC 864
Cdd:pfam02460 694 ISMITIIMSIGFSVDFSAHIAYHFVRSRGDT-PAERVVDALEALGWPVFQGGLSTILGVLVLLFVPSYMVVVFFKTVFLV 772
|
810
....*....|....*....
gi 115532069 865 MILCVFHALVLLPCLFAIF 883
Cdd:pfam02460 773 VAIGLLHGLFILPIILSLF 791
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
28-886 |
9.86e-27 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 117.27 E-value: 9.86e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 28 WFFEKWSHFVADHAVALIVICVVLTLIGTFKVATTPNDNDITGYTPYGARARDEFDVMTDFFahnGNGIAMFVLIlpTRH 107
Cdd:COG1033 2 RLMERLARFILRHRKLVLLLFLLLTLLLAYGAPKLEVDTDFESLLPEDDPSVQAYDEFEEEF---GGDDTVVVAV--EGK 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 108 ESVLHPDVLREALRLEDILSTNfsmlsadgkpenyqefctnfcqinePFVQFARSYLT--ELDNSKNGTDLSERISLNYP 185
Cdd:COG1033 77 DDIFTPETLEALRELTEELEEI-------------------------PGVDSVTSLTNvrATEGTEDGLTVEPLIPDELP 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 186 IT--SIYSRKMSIQPNFFGIEMMNETKKSITnirsskLIALQLRSERKEGwnsngiKDFEMSITNYLEK---EFESPEIR 260
Cdd:COG1033 132 ASpeELAELREKVLSSPLYVGRLVSPDGKAT------LIVVTLDPDPLSS------DLDRKEVVAEIRAiiaKYEDPGVE 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 261 VLTLSTSYVEAEVVRAGMS-LLPFLIVGFVIMAIVSSVTTffsavymqqvsiHKFSLAIAACICPFMACGTALGALFFCG 339
Cdd:COG1033 200 VYLTGFPVLRGDIAEAIQSdLAIFFPLALLLILLLLFLFF------------RSLRGVLLPLLVVLLAVIWTLGLMGLLG 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 340 VRFGSILCVTPFLVLAIGVDDAylmIHSWQRVTAERRKHpvanDSPGSRLSEVLVDTGPAILISALTNIFADVAGCFTSS 419
Cdd:COG1033 268 IPLSPLTILVPPLLLAIGIDYG---IHLLNRYREERRKG----LDKREALREALRKLGPPVLLTSLTTAIGFLSLLFSDI 340
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 420 PEISLLGYGNMACIFCDFLYQITFYSAIMTltgYFEMKDEEQKRHIKKIACGADSDDSSctsssvesfDVIVKRRVTsfl 499
Cdd:COG1033 341 PPIRDFGIVAAIGVLLAFLTSLTLLPALLS---LLPRPKPKTRRLKKPPELGRLLAKLA---------RFVLRRPKV--- 405
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 500 enyislitnaffqifVVLVWIAFLVVSIYGITIMNINLSPRKLFMEDSSLREMDDLrVKYVIPNFYLANVFVR--KPGDL 577
Cdd:COG1033 406 ---------------ILVVALVLAVVSLYGISRLKVEYDFEDYLPEDSPIRQDLDF-IEENFGGSDPLEVVVDtgEPDGL 469
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 578 TDGARLQRLNQFVEEMEHLNGSWGSLGTNYFVRDFvnfqaamveeeeaeggeeeASIVKRGGIDVNNLP-------MFLE 650
Cdd:COG1033 470 KDPEVLKEIDRLQDYLESLPEVGKVLSLADLVKEL-------------------NQALNEGDPKYYALPesrellaQLLL 530
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 651 WPEYLFWKGFVQFHSAENRTVldRFFITFAIHGTNlqswpARGDALREWRNVVDKYSAEFGLSVF--SDDGIYVDLIENM 728
Cdd:COG1033 531 LLSSPPGDDLSRFVDEDYSAA--RVTVRLKDLDSE-----EIKALVEEVRAFLAENFPPDGVEVTltGSAVLFAAINESV 603
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 729 PTDAWQSAVATLACMAFICFVFMYDVptVMVATSIIASIMT--GILGILSLTGTDLDPIVMSALIISIGFSVDIPAHISY 806
Cdd:COG1033 604 IESQIRSLLLALLLIFLLLLLAFRSL--RLGLISLIPNLLPilLTFGLMGLLGIPLNIATAVVASIALGIGVDYTIHFLS 681
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 807 HY-HTSPSDNGIRHRLHKTLSSVGFPALQATVSTSLCVLSLKFSSIYMSCAFVKTMITCMILCVFHALVLLPCLFAIFHR 885
Cdd:COG1033 682 RYrEERRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLLLPALLLLLDP 761
|
.
gi 115532069 886 I 886
Cdd:COG1033 762 R 762
|
|
| 2A060601 |
TIGR00917 |
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ... |
29-883 |
3.49e-21 |
|
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]
Pssm-ID: 273337 [Multi-domain] Cd Length: 1205 Bit Score: 99.98 E-value: 3.49e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 29 FFEKWSHFVADHAVALIVICVVLTL---IGTFKVATTPNDNDItgYTPYGARARDE---FDV-MTDFFAHNGNGIAMFVL 101
Cdd:TIGR00917 312 FFGKYGIWVARHPTLVICLSVSVVLllcVGLIRFKVETRPVKL--WVAPGSRAALEkqyFDThFGPFYRIEQLIIATVQT 389
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 102 ILPTRHESVLHPDVLREALRLEDILSTNFSmlSADGKPENYQEFCTnfcQINEPFVQFARSYLTELDNS------KNGTD 175
Cdd:TIGR00917 390 SSHEKAPEILTDDNLKLLFDIQKKVSQLFA--NYEGELITLDSPCF---KPNHPYNCFIYSTCKKLQNMysklkpENYDD 464
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 176 --LSERI-----SLNYPITSIYSRKMSIQPNFF--GIEMMNetkksiTNIRSSKLIALQLRSERKEGWNSNGIKDFEMSI 246
Cdd:TIGR00917 465 ygGVDYVkycfeHFTSPESCLSAFGGPVDPTTVlgGFSGNN------FSEASAFVVTFPVNNFVNKTNKTEKAVAWEKAF 538
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 247 TNYLEKEFESPEIRVLTLST-SYVEAEVVRAGMSLLPFLIVGFVIMAIVSSVTTFFSAVYMQQVSIHKFSLAIAACICPF 325
Cdd:TIGR00917 539 IQLAKDELLPMVQATISFSAeRSIEDELKRESTADVITIAISYLVMFAYISLTLGDSPRLKSLYVTSKVLLGLSGILIVM 618
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 326 MACGTALGALFFCGVRFGSILC-VTPFLVLAIGVDDAYLMIHSWQRVTAERRKHPVANDSPGS---RLSEVLVDTGPAIL 401
Cdd:TIGR00917 619 LSVLGSVGVFSAVGLKSTLIIMeVIPFLVLAVGVDNIFILVFFYFYLEYFYRQVGVDNEQELTlerRLSRALMEVGPSIT 698
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 402 ISALTNIFADVAGCFTSSPEISLLGYGNMACIFCDFLYQITFYSAIMTltgyFEMKDEEQKRhIKKIACGADSDDSSCTS 481
Cdd:TIGR00917 699 LASLSEILAFALGALIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLV----LDFKRTEDKR-VDCFPCIKTSKSSISAE 773
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 482 SSVESFDVIVKRRVtsFLENYISLITNAFFQIFVVLVWIAFLVVSIYGITIMNINLSPRKLFMEDSSLREMDDLRVKY-- 559
Cdd:TIGR00917 774 KGSGQRKAGLLTRY--FKEVYAPVLLHWIVKIVVIAFFVGLLMAGIALSTRVEIGLDQQIVLPQDSYLQIYFASLTPLle 851
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 560 VIPNFYlanvFVRKPG-DLTD-----------GARLQRLNQFVEEMEHLNGSWGSLGTNYFV----------RDFVNFQA 617
Cdd:TIGR00917 852 VGPPFY----IVIKGDyNYTDfesqnklctmgGCDKDSIVNVFNNLSYIAKPASSWLDDYLVwlspqascccRKFTNGTF 927
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 618 AMVEEEEAEGGEEEASIVKR---GGIDVNNLPMFL-EWPEYLFWKGFVQFHSAENRTVLDRFFI---TFAIHGTNLQSWP 690
Cdd:TIGR00917 928 CNGPDPQCFRCADLSSDAQGrpsTTQFKEKLPWFLnALPSADCAKGGHAAYSSAVDLQGYATIIqasSFRTYHTPLNTQV 1007
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 691 ARGDALREWRNVVDKYSAEFGLSVFSDDGIYV--DLIENMPTDAWQSAVATLACMAFICFVFMYDVPTVMVATSI-IASI 767
Cdd:TIGR00917 1008 DFINAMRAAQEFAAKVSRSSKMEVYPYSVFYVffEQYLTIWKTAIINLSIALGAIFIVCLFLLQLNALSVVNLIMsVGMA 1087
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 768 MTGILGILSLTGTDLDPIVMSALIISIGFSVDIPAHISYHYHTSPSDNGIrHRLHKTLSSVG---FPALQATVSTSLCVL 844
Cdd:TIGR00917 1088 VVFCVGIMHLWSISLNAVSVVNSVMHKGIAIEFCTHINAQFSTGKHFSRN-HRAKEALGGMGssvFSGITLTKLVGVVVL 1166
|
890 900 910
....*....|....*....|....*....|....*....
gi 115532069 845 SLKFSSIYMSCAFvKTMITCMILCVFHALVLLPCLFAIF 883
Cdd:TIGR00917 1167 GFSRSEIFVVYYF-RMYLALVLLGFLHGLVFLPVLLSVL 1204
|
|
| Sterol-sensing |
pfam12349 |
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ... |
313-450 |
9.58e-21 |
|
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.
Pssm-ID: 463544 [Multi-domain] Cd Length: 153 Bit Score: 89.56 E-value: 9.58e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 313 KFSLAIAACICPFMACGTALGALFFCGVRFGSI-LCVTPFLVLAIGVDDAYLMIHSWQRVTAERRKHpvandspgSRLSE 391
Cdd:pfam12349 5 KFGLGLAGVIIVLASVASSLGLCAYFGLPLTLIiSEVIPFLVLAIGVDNIFLLVKAVVRTPRSLDVS--------ERIAE 76
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 115532069 392 VLVDTGPAILISALTNIFADVAGCFTSSPEISLLGYGNMACIFCDFLYQITFYSAIMTL 450
Cdd:pfam12349 77 ALGEVGPSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSL 135
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
496-901 |
2.36e-14 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 77.21 E-value: 2.36e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 496 TSFLENYISLITNafFQIFVVLVWIAFLVVSIYGITIMNINLSPRKLFMEDS-SLREMDDLRVKYVIPNFYLanVFVRKP 574
Cdd:COG1033 1 ERLMERLARFILR--HRKLVLLLFLLLTLLLAYGAPKLEVDTDFESLLPEDDpSVQAYDEFEEEFGGDDTVV--VAVEGK 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 575 GDLTDGARLQRLNQFVEEMEHLNGSWGSLGTNYFVRDFVNFQAAMVEEEEAEGGEEEASIVKRGGIDVNNLPMFLEwpey 654
Cdd:COG1033 77 DDIFTPETLEALRELTEELEEIPGVDSVTSLTNVRATEGTEDGLTVEPLIPDELPASPEELAELREKVLSSPLYVG---- 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 655 lfwkgfvQFHSAENRTVLdrFFITFAIHGTNlqSWPARGDALREWRNVVDKYSAE------FGLSVfsddgIYVDLIENM 728
Cdd:COG1033 153 -------RLVSPDGKATL--IVVTLDPDPLS--SDLDRKEVVAEIRAIIAKYEDPgvevylTGFPV-----LRGDIAEAI 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 729 PTDAWQSAVATLACMAFICFVFMYDVPTVM--VATSIIASIMTgiLGILSLTGTDLDPIVMS--ALIISIGFSVDIPAHI 804
Cdd:COG1033 217 QSDLAIFFPLALLLILLLLFLFFRSLRGVLlpLLVVLLAVIWT--LGLMGLLGIPLSPLTILvpPLLLAIGIDYGIHLLN 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 805 SYHYHTSPSDNgIRHRLHKTLSSVGFPALQATVSTSLCVLSLKFSSIYMSCAFVKTMITCMILCVFHALVLLPCLFAIFH 884
Cdd:COG1033 295 RYREERRKGLD-KREALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSLTLLPALLSLLP 373
|
410
....*....|....*..
gi 115532069 885 RIHSLFRVPKTSPIESK 901
Cdd:COG1033 374 RPKPKTRRLKKPPELGR 390
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
15-426 |
2.79e-13 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 73.74 E-value: 2.79e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 15 EAVKTTRLVRGISWFFEKWSHFVADHAVALIVICVVLTLIGTFKVATTPNDNDITGYTPYGARARDEFDVMTDFFahngN 94
Cdd:COG1033 377 PKTRRLKKPPELGRLLAKLARFVLRRPKVILVVALVLAVVSLYGISRLKVEYDFEDYLPEDSPIRQDLDFIEENF----G 452
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 95 GIAMFVLILPT-RHESVLHPDVLREALRLEDILStnfsmlsadgkpenyqefctnfcqiNEPFVQFARSYLT---ELDNS 170
Cdd:COG1033 453 GSDPLEVVVDTgEPDGLKDPEVLKEIDRLQDYLE-------------------------SLPEVGKVLSLADlvkELNQA 507
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 171 KNGTDLSE-RISLNYPITSIYSRKMSIQPNFFGIEMMNETKKSITnirssklIALQLRSERkegwnSNGIKDFEMSITNY 249
Cdd:COG1033 508 LNEGDPKYyALPESRELLAQLLLLLSSPPGDDLSRFVDEDYSAAR-------VTVRLKDLD-----SEEIKALVEEVRAF 575
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 250 LEKEFESPEIRVLTLSTSYVEA---EVVRAG---MSLLPFLIVgFVIMAIVssvttffsavymqqvsIHKFSLAIAACIC 323
Cdd:COG1033 576 LAENFPPDGVEVTLTGSAVLFAainESVIESqirSLLLALLLI-FLLLLLA----------------FRSLRLGLISLIP 638
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 324 PFMACGTALGALFFCGVRFG-SILCVTPfLVLAIGVDDAYLMIHswqRVTAERRKHPvandSPGSRLSEVLVDTGPAILI 402
Cdd:COG1033 639 NLLPILLTFGLMGLLGIPLNiATAVVAS-IALGIGVDYTIHFLS---RYREERRKGG----DLEEAIRRALRTTGKAILF 710
|
410 420
....*....|....*....|....
gi 115532069 403 SALTNIFADVAGCFTSSPEISLLG 426
Cdd:COG1033 711 TSLTLAAGFGVLLFSSFPPLADFG 734
|
|
| 2A060602 |
TIGR00918 |
The Eukaryotic (Putative) Sterol Transporter (EST) Family; |
740-883 |
1.07e-08 |
|
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
Pssm-ID: 273338 [Multi-domain] Cd Length: 1145 Bit Score: 59.12 E-value: 1.07e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 740 LACMAFICFVFMYDVPTVMVATSIIASIMTGILGILSLTGTDLDPIVMSALIISIGFSVDIPAHISYHYHTSPSDNGIR- 818
Cdd:TIGR00918 975 LACTFLVCALLLLNPWTAGLIVLVLALMTVELFGMMGLLGIKLSAIPVVILIASVGIGVEFTVHIALGFLTAIGDRNRRa 1054
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 115532069 819 -HRLHKTLSsvgfPALQATVSTSLCVLSL---KFSSIYMSCAFVKTMITCMILCvfHALVLLPCLFAIF 883
Cdd:TIGR00918 1055 vLALEHMFA----PVLDGALSTLLGVLMLagsEFDFIVRYFFAVLAVLTCLGVL--NGLVLLPVLLSMF 1117
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
26-450 |
9.31e-05 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 46.37 E-value: 9.31e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 26 ISWFFEKWSHFVADHAVALIVICVVLTLIGTFKVATTPNDNDITGYTPYGARARDEFDVMTDFFahNGNGIAMFVLILPt 105
Cdd:TIGR00921 368 IEEELSKVLSITVRHPVPALVAALIITGLGLYGAAGIKPEVNIEKFIPQDLPSLQARKVIESHM--GGSHDFATILVKA- 444
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 106 rhESVLHPDVLREALRLE-DILstnfsmlsadgkpenyqefctnfcqinepfvqfARSYLTELDNSKNGTDL-SERISLN 183
Cdd:TIGR00921 445 --DDVRDPELVRFMDELSrDIK---------------------------------ATGVAARVFGAPSIIDLvKEVEGLP 489
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 184 YPITSIYSRKMSiqpnffgiemmNETKKSITNirssklialqlrSERKEGWNSNGIK--DFEM---SITNYLEKEFESPE 258
Cdd:TIGR00921 490 APERSALEPIPE-----------DEEGGYISG------------GQIKVAVIQVQLKqgEPKVqgrKILRDVQHEHPPPG 546
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 259 IRVLTLSTSYVEAEVV------RAGMSLLPFLIVGFVIMAIVSSVTTffsavymqqvsihkfslAIAACICPFMACGTAL 332
Cdd:TIGR00921 547 VKVGVTGLPVAFAEMHelvnegMRRMTIAGAILVLMILLAVFRNPIK-----------------AVFPLIAIGSGILWAI 609
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 333 GALFFCGVRFGSILCVTPFLVLAIGVDDAYLMIHswqRVTAERRKHpvandSPGSRLSEVLVDTGPAILISALTNIFADV 412
Cdd:TIGR00921 610 GLMGLRGIPSFLAMATTISIILGLGMDYSIHLAE---RYFEERKEH-----GPKEAITHTMERTGPGILFSGLTTAGGFL 681
|
410 420 430
....*....|....*....|....*....|....*...
gi 115532069 413 AGCFTSSPEISLLGYGNMACIFCDFLYQITFYSAIMTL 450
Cdd:TIGR00921 682 SLLLSHFPIMRNFGLVQGIGVLSSLTAALVVFPALLVL 719
|
|
| AcrB |
COG0841 |
Multidrug efflux pump subunit AcrB [Defense mechanisms]; |
700-887 |
5.07e-03 |
|
Multidrug efflux pump subunit AcrB [Defense mechanisms];
Pssm-ID: 440603 [Multi-domain] Cd Length: 1015 Bit Score: 40.86 E-value: 5.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 700 RNVVDKYSAEFG----LSVFSDDGIYVDL-IENMPTDAWQSAVatLAcmAFICFVFMYDV-PTVMVATSIIASIMTGILg 773
Cdd:COG0841 300 RAKLEELQASLPegveLTIVYDQSEFIRAsIEEVVKTLLEAIL--LV--VLVVFLFLRSWrATLIPAVAIPVSLIGTFA- 374
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 774 ILSLTGTDLDPIVMSALIISIGFSVD--------IPAHISYHYhtSPSDNGIrhrlhKTLSSVGFPALQATVSTSLCVLS 845
Cdd:COG0841 375 VMYLLGFSLNILTLFALVLAIGIVVDdaivvvenIERHMEEGL--SPLEAAI-----KGAREVAGAVIASTLTLVAVFLP 447
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 115532069 846 LKFSS-----IYMSCAFvkTMITCMILCVFHALVLLPCLFAIFHRIH 887
Cdd:COG0841 448 LAFMGgitgqLFRQFAL--TVAIALLISLFVALTLTPALCARLLKPH 492
|
|
| ACR_tran |
pfam00873 |
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ... |
712-889 |
5.26e-03 |
|
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.
Pssm-ID: 395701 [Multi-domain] Cd Length: 1021 Bit Score: 40.74 E-value: 5.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 712 LSVFSDDGIYVDL-IENMPTDAWQSAVatLACMafICFVFMYDVP-TVMVATSIIASIMtGILGILSLTGTDLDPIVMSA 789
Cdd:pfam00873 316 IVVVYDTTPFIRAsIEEVVKTLLEAIV--LVIL--VMFLFLQNWRaTLIPAIAIPLSLL-GTFAVMKAFGFSINTLTLGG 390
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532069 790 LIISIGFSVD--------IPAHISyHYHTSPsdngiRHRLHKTLSSVGFPALQATVSTSLCVLSLKFSS-----IYMSCA 856
Cdd:pfam00873 391 LVLAIGLVVDdaivvvenIERVLE-ENGLKP-----LEAAYKSMGEIGGALVAIALVLSAVFLPILFLGgltgrIFRQFA 464
|
170 180 190
....*....|....*....|....*....|...
gi 115532069 857 FvkTMITCMILCVFHALVLLPCLFAIFHRIHSL 889
Cdd:pfam00873 465 I--TIVLAILLSVLVALTLTPALCATLLKPRRE 495
|
|
| |
