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Conserved domains on  [gi|392884801|ref|NP_001021822|]
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Hemolysin-III related-domain-containing protein [Caenorhabditis elegans]

Protein Classification

AdipoR/hemolysin III family protein( domain architecture ID 2520)

AdipoR/hemolysin III family protein similar to adiponectin receptors (AdipoRs), which are integral membrane proteins that control glucose and lipid metabolism by mediating cellular ceramidase activity

PubMed:  28329765

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HlyIII super family cl03831
Haemolysin-III related; Members of this family are integral membrane proteins. This family ...
 37-133 7.37e-19

Haemolysin-III related; Members of this family are integral membrane proteins. This family includes a protein with hemolytic activity from Bacillus cereus. It has been proposed that YOL002c encodes a Saccharomyces cerevisiae protein that plays a key role in metabolic pathways that regulate lipid and phosphate metabolism. In eukaryotes, members are seven-transmembrane pass molecules found to encode functional receptors with a broad range of apparent ligand specificities, including progestin and adipoQ receptors, and hence have been named PAQR proteins. The mammalian members include progesterone binding proteins. Unlike the case with GPCR receptor proteins, the evolutionary ancestry of the members of this family can be traced back to the Archaea. This family belongs to the CREST superfamily, which are distantly related to GPCRs.


The actual alignment was detected with superfamily member TIGR01065:

Pssm-ID: 470885  Cd Length: 204  Bit Score: 80.45  E-value: 7.37e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884801   37 EHVANTVSHAIGIGP-----TILVFYYFMCayaHRDLQHILMIIYGIFTTLLFTSSTVYHfcellfrQQNKHRKLRYYLH 111
Cdd:TIGR01065   1 EEIANAITHGIGAVLsiialALLVIYSWDH---GGAVAVLGFSIYGISLILLFLVSTLYH-------SIPKGSKAKNWLR 70

                          90       100
                  ....*....|....*....|..
gi 392884801  112 ICDRAAIYLFIAASYTPWLTLR 133
Cdd:TIGR01065  71 KIDHSMIYVLIAGTYTPFLLLA 92
 
Name Accession Description Interval E-value
hlyIII TIGR01065
channel protein, hemolysin III family; This family includes proteins from pathogenic and ...
 37-133 7.37e-19

channel protein, hemolysin III family; This family includes proteins from pathogenic and non-pathogenic bacteria, Homo sapiens and Drosophila. In Bacillus cereus, a pathogen, it has been show to function as a channel-forming cytolysin. The human protein is expressed preferentially in mature macrophages, consistent with a role cytolytic role.


Pssm-ID: 273425  Cd Length: 204  Bit Score: 80.45  E-value: 7.37e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884801   37 EHVANTVSHAIGIGP-----TILVFYYFMCayaHRDLQHILMIIYGIFTTLLFTSSTVYHfcellfrQQNKHRKLRYYLH 111
Cdd:TIGR01065   1 EEIANAITHGIGAVLsiialALLVIYSWDH---GGAVAVLGFSIYGISLILLFLVSTLYH-------SIPKGSKAKNWLR 70

                          90       100
                  ....*....|....*....|..
gi 392884801  112 ICDRAAIYLFIAASYTPWLTLR 133
Cdd:TIGR01065  71 KIDHSMIYVLIAGTYTPFLLLA 92
YqfA COG1272
Predicted membrane channel-forming protein YqfA, hemolysin III family [Intracellular ...
 37-133 1.03e-16

Predicted membrane channel-forming protein YqfA, hemolysin III family [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440883  Cd Length: 213  Bit Score: 74.80  E-value: 1.03e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884801  37 EHVANTVSHAIG-----IGPTILVFYyfmcAYAHRDLQHIL-MIIYGIFTTLLFTSSTVYHFCellfrqqnKHRKLRYYL 110
Cdd:COG1272   11 EEIANAITHGIGallaiAGLVVLIVL----AALSGDAWAIVsFSIYGASLILLYLASTLYHSL--------PSPRAKRVL 78

                         90       100
                 ....*....|....*....|....*
gi 392884801 111 HICDRAAIYLFIAASYTP--WLTLR 133
Cdd:COG1272   79 RRLDHSAIYLLIAGTYTPfaLIALR 103
PRK15087 PRK15087
hemolysin; Provisional
 37-130 3.00e-08

hemolysin; Provisional


Pssm-ID: 185044  Cd Length: 219  Bit Score: 51.63  E-value: 3.00e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884801  37 EHVANTVSHAIGI--GPTILVFYYFMCAYAHRDLQHIL-MIIYGIFTTLLFTSSTVYHFCellfrqqnKHRKLRYYLHIC 113
Cdd:PRK15087  15 EEIANSISHGIGLvfGIVGLVLLLVQAVDANADATAITsYSLYGGSMILLFLASTLYHAI--------PHQRAKRWLKKF 86

                         90
                 ....*....|....*..
gi 392884801 114 DRAAIYLFIAASYTPWL 130
Cdd:PRK15087  87 DHCAIYLLIAGTYTPFL 103
HlyIII pfam03006
Haemolysin-III related; Members of this family are integral membrane proteins. This family ...
 36-130 5.19e-07

Haemolysin-III related; Members of this family are integral membrane proteins. This family includes a protein with hemolytic activity from Bacillus cereus. It has been proposed that YOL002c encodes a Saccharomyces cerevisiae protein that plays a key role in metabolic pathways that regulate lipid and phosphate metabolism. In eukaryotes, members are seven-transmembrane pass molecules found to encode functional receptors with a broad range of apparent ligand specificities, including progestin and adipoQ receptors, and hence have been named PAQR proteins. The mammalian members include progesterone binding proteins. Unlike the case with GPCR receptor proteins, the evolutionary ancestry of the members of this family can be traced back to the Archaea. This family belongs to the CREST superfamily, which are distantly related to GPCRs.


Pssm-ID: 427098  Cd Length: 222  Bit Score: 48.04  E-value: 5.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884801   36 HEHVANTVSHAIGIGPTI-LVFYYFMCAYAHRDLQHIL-MIIYGIFTTLLFTSSTVYHfcellfRQQNKHRKLRYYLHIC 113
Cdd:pfam03006   4 HNETLNIWTHLLGAILFIaLLIFLLALATIDSQLSAVLpFLIFLLSACLCLGCSALYH------TFSCHSEKVRKLFRKL 77

                          90
                  ....*....|....*..
gi 392884801  114 DRAAIYLFIAASYTPWL 130
Cdd:pfam03006  78 DYSGIFLLIAGSYTPVI 94
 
Name Accession Description Interval E-value
hlyIII TIGR01065
channel protein, hemolysin III family; This family includes proteins from pathogenic and ...
 37-133 7.37e-19

channel protein, hemolysin III family; This family includes proteins from pathogenic and non-pathogenic bacteria, Homo sapiens and Drosophila. In Bacillus cereus, a pathogen, it has been show to function as a channel-forming cytolysin. The human protein is expressed preferentially in mature macrophages, consistent with a role cytolytic role.


Pssm-ID: 273425  Cd Length: 204  Bit Score: 80.45  E-value: 7.37e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884801   37 EHVANTVSHAIGIGP-----TILVFYYFMCayaHRDLQHILMIIYGIFTTLLFTSSTVYHfcellfrQQNKHRKLRYYLH 111
Cdd:TIGR01065   1 EEIANAITHGIGAVLsiialALLVIYSWDH---GGAVAVLGFSIYGISLILLFLVSTLYH-------SIPKGSKAKNWLR 70

                          90       100
                  ....*....|....*....|..
gi 392884801  112 ICDRAAIYLFIAASYTPWLTLR 133
Cdd:TIGR01065  71 KIDHSMIYVLIAGTYTPFLLLA 92
YqfA COG1272
Predicted membrane channel-forming protein YqfA, hemolysin III family [Intracellular ...
 37-133 1.03e-16

Predicted membrane channel-forming protein YqfA, hemolysin III family [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440883  Cd Length: 213  Bit Score: 74.80  E-value: 1.03e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884801  37 EHVANTVSHAIG-----IGPTILVFYyfmcAYAHRDLQHIL-MIIYGIFTTLLFTSSTVYHFCellfrqqnKHRKLRYYL 110
Cdd:COG1272   11 EEIANAITHGIGallaiAGLVVLIVL----AALSGDAWAIVsFSIYGASLILLYLASTLYHSL--------PSPRAKRVL 78

                         90       100
                 ....*....|....*....|....*
gi 392884801 111 HICDRAAIYLFIAASYTP--WLTLR 133
Cdd:COG1272   79 RRLDHSAIYLLIAGTYTPfaLIALR 103
PRK15087 PRK15087
hemolysin; Provisional
 37-130 3.00e-08

hemolysin; Provisional


Pssm-ID: 185044  Cd Length: 219  Bit Score: 51.63  E-value: 3.00e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884801  37 EHVANTVSHAIGI--GPTILVFYYFMCAYAHRDLQHIL-MIIYGIFTTLLFTSSTVYHFCellfrqqnKHRKLRYYLHIC 113
Cdd:PRK15087  15 EEIANSISHGIGLvfGIVGLVLLLVQAVDANADATAITsYSLYGGSMILLFLASTLYHAI--------PHQRAKRWLKKF 86

                         90
                 ....*....|....*..
gi 392884801 114 DRAAIYLFIAASYTPWL 130
Cdd:PRK15087  87 DHCAIYLLIAGTYTPFL 103
HlyIII pfam03006
Haemolysin-III related; Members of this family are integral membrane proteins. This family ...
 36-130 5.19e-07

Haemolysin-III related; Members of this family are integral membrane proteins. This family includes a protein with hemolytic activity from Bacillus cereus. It has been proposed that YOL002c encodes a Saccharomyces cerevisiae protein that plays a key role in metabolic pathways that regulate lipid and phosphate metabolism. In eukaryotes, members are seven-transmembrane pass molecules found to encode functional receptors with a broad range of apparent ligand specificities, including progestin and adipoQ receptors, and hence have been named PAQR proteins. The mammalian members include progesterone binding proteins. Unlike the case with GPCR receptor proteins, the evolutionary ancestry of the members of this family can be traced back to the Archaea. This family belongs to the CREST superfamily, which are distantly related to GPCRs.


Pssm-ID: 427098  Cd Length: 222  Bit Score: 48.04  E-value: 5.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884801   36 HEHVANTVSHAIGIGPTI-LVFYYFMCAYAHRDLQHIL-MIIYGIFTTLLFTSSTVYHfcellfRQQNKHRKLRYYLHIC 113
Cdd:pfam03006   4 HNETLNIWTHLLGAILFIaLLIFLLALATIDSQLSAVLpFLIFLLSACLCLGCSALYH------TFSCHSEKVRKLFRKL 77

                          90
                  ....*....|....*..
gi 392884801  114 DRAAIYLFIAASYTPWL 130
Cdd:pfam03006  78 DYSGIFLLIAGSYTPVI 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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