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Conserved domains on  [gi|82880674|ref|NP_001025125|]
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cerebral dopamine neurotrophic factor precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ARMET_N pfam20145
ARMET, N-terminal; This is the N-terminal domain of ARMET proteins (also known as ...
 36-132 2.43e-54

ARMET, N-terminal; This is the N-terminal domain of ARMET proteins (also known as mesencephalic astrocyte-derived neurotrophic factor (MANF) or arginine-rich protein), a saposin-like domain consisting of five alpha-helices with three cystein bridges that stabilizes the globular "closed leaf" conformation. ARMET is a small protein of approximately 170 residues which contain four di-sulfide bridges that are highly conserved from nematodes to humans. It is a soluble protein resident in the endoplasmic reticulum and induced by ER stress. It appears to be involved with dealing with mis-folded proteins in the ER, thus in quality control of ER stress.


:

Pssm-ID: 466306  Cd Length: 97  Bit Score: 167.44  E-value: 2.43e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82880674    36 DCEVCKEFLNRFYKSLIDRGVNFSLDTIEKELISFCLDTKGKENRLCYYLGATKDAATKILSEVTRPMSVHMPAMKICEK 115
Cdd:pfam20145   1 DCEVCVKFLFRFYLSLKYAEKSFAPKEIEEELRKFCKETKGKENRFCYYLGALEDSATKILSEVSKPLSWHVPAEKICEK 80

                          90
                  ....*....|....*..
gi 82880674   116 LKKLDSQICELKYEKTL 132
Cdd:pfam20145  81 LKKKDSQICELRYEKEL 97
ARMET_C pfam10208
ARMET, C-terminal; This is the C-terminal domain of ARMET (also known as mesencephalic ...
 136-178 3.87e-22

ARMET, C-terminal; This is the C-terminal domain of ARMET (also known as mesencephalic astrocyte-derived neurotrophic factor (MANF) or arginine-rich protein). This domain is well conserved among Armet family proteins whose structure is composed of a basic-helix-loop-helix (bHLH) motif. ARMET is a small protein of approximately 170 residues. It is soluble protein resident in the endoplasmic reticulum and induced by ER stress. It appears to be involved with dealing with mis-folded proteins in the ER, thus in quality control of ER stress.


:

Pssm-ID: 462997  Cd Length: 43  Bit Score: 83.90  E-value: 3.87e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 82880674   136 SVDLRKMRVAELKQILHSWGEECRACAEKTDYVNLIQELAPKY 178
Cdd:pfam10208   1 TVDLKKLRVKELKKILADWGEECRGCLEKTDFIKLIEELAPKY 43
 
Name Accession Description Interval E-value
ARMET_N pfam20145
ARMET, N-terminal; This is the N-terminal domain of ARMET proteins (also known as ...
 36-132 2.43e-54

ARMET, N-terminal; This is the N-terminal domain of ARMET proteins (also known as mesencephalic astrocyte-derived neurotrophic factor (MANF) or arginine-rich protein), a saposin-like domain consisting of five alpha-helices with three cystein bridges that stabilizes the globular "closed leaf" conformation. ARMET is a small protein of approximately 170 residues which contain four di-sulfide bridges that are highly conserved from nematodes to humans. It is a soluble protein resident in the endoplasmic reticulum and induced by ER stress. It appears to be involved with dealing with mis-folded proteins in the ER, thus in quality control of ER stress.


Pssm-ID: 466306  Cd Length: 97  Bit Score: 167.44  E-value: 2.43e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82880674    36 DCEVCKEFLNRFYKSLIDRGVNFSLDTIEKELISFCLDTKGKENRLCYYLGATKDAATKILSEVTRPMSVHMPAMKICEK 115
Cdd:pfam20145   1 DCEVCVKFLFRFYLSLKYAEKSFAPKEIEEELRKFCKETKGKENRFCYYLGALEDSATKILSEVSKPLSWHVPAEKICEK 80

                          90
                  ....*....|....*..
gi 82880674   116 LKKLDSQICELKYEKTL 132
Cdd:pfam20145  81 LKKKDSQICELRYEKEL 97
ARMET_C pfam10208
ARMET, C-terminal; This is the C-terminal domain of ARMET (also known as mesencephalic ...
 136-178 3.87e-22

ARMET, C-terminal; This is the C-terminal domain of ARMET (also known as mesencephalic astrocyte-derived neurotrophic factor (MANF) or arginine-rich protein). This domain is well conserved among Armet family proteins whose structure is composed of a basic-helix-loop-helix (bHLH) motif. ARMET is a small protein of approximately 170 residues. It is soluble protein resident in the endoplasmic reticulum and induced by ER stress. It appears to be involved with dealing with mis-folded proteins in the ER, thus in quality control of ER stress.


Pssm-ID: 462997  Cd Length: 43  Bit Score: 83.90  E-value: 3.87e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 82880674   136 SVDLRKMRVAELKQILHSWGEECRACAEKTDYVNLIQELAPKY 178
Cdd:pfam10208   1 TVDLKKLRVKELKKILADWGEECRGCLEKTDFIKLIEELAPKY 43
 
Name Accession Description Interval E-value
ARMET_N pfam20145
ARMET, N-terminal; This is the N-terminal domain of ARMET proteins (also known as ...
 36-132 2.43e-54

ARMET, N-terminal; This is the N-terminal domain of ARMET proteins (also known as mesencephalic astrocyte-derived neurotrophic factor (MANF) or arginine-rich protein), a saposin-like domain consisting of five alpha-helices with three cystein bridges that stabilizes the globular "closed leaf" conformation. ARMET is a small protein of approximately 170 residues which contain four di-sulfide bridges that are highly conserved from nematodes to humans. It is a soluble protein resident in the endoplasmic reticulum and induced by ER stress. It appears to be involved with dealing with mis-folded proteins in the ER, thus in quality control of ER stress.


Pssm-ID: 466306  Cd Length: 97  Bit Score: 167.44  E-value: 2.43e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82880674    36 DCEVCKEFLNRFYKSLIDRGVNFSLDTIEKELISFCLDTKGKENRLCYYLGATKDAATKILSEVTRPMSVHMPAMKICEK 115
Cdd:pfam20145   1 DCEVCVKFLFRFYLSLKYAEKSFAPKEIEEELRKFCKETKGKENRFCYYLGALEDSATKILSEVSKPLSWHVPAEKICEK 80

                          90
                  ....*....|....*..
gi 82880674   116 LKKLDSQICELKYEKTL 132
Cdd:pfam20145  81 LKKKDSQICELRYEKEL 97
ARMET_C pfam10208
ARMET, C-terminal; This is the C-terminal domain of ARMET (also known as mesencephalic ...
 136-178 3.87e-22

ARMET, C-terminal; This is the C-terminal domain of ARMET (also known as mesencephalic astrocyte-derived neurotrophic factor (MANF) or arginine-rich protein). This domain is well conserved among Armet family proteins whose structure is composed of a basic-helix-loop-helix (bHLH) motif. ARMET is a small protein of approximately 170 residues. It is soluble protein resident in the endoplasmic reticulum and induced by ER stress. It appears to be involved with dealing with mis-folded proteins in the ER, thus in quality control of ER stress.


Pssm-ID: 462997  Cd Length: 43  Bit Score: 83.90  E-value: 3.87e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 82880674   136 SVDLRKMRVAELKQILHSWGEECRACAEKTDYVNLIQELAPKY 178
Cdd:pfam10208   1 TVDLKKLRVKELKKILADWGEECRGCLEKTDFIKLIEELAPKY 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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