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Conserved domains on  [gi|85702209|ref|NP_001030041|]
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uncharacterized protein LOC245263 [Mus musculus]

Protein Classification

homeobox domain-containing protein( domain architecture ID 10052840)

homeobox domain-containing protein may be involved in the transcriptional regulation of key eukaryotic developmental processes

Gene Ontology:  GO:0003677|GO:0006357|GO:0043565
PubMed:  1357790|26464018|21557080

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 6-56 2.60e-11

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


:

Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 58.02  E-value: 2.60e-11
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 85702209   6 RRPHTGLTLSQRRILAQAFERNPRPGCATREELALETGLPEDMIHTWLKNK 56
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNR 51
 
Name Accession Description Interval E-value
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 6-56 2.60e-11

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 58.02  E-value: 2.60e-11
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 85702209   6 RRPHTGLTLSQRRILAQAFERNPRPGCATREELALETGLPEDMIHTWLKNK 56
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNR 51
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 5-56 9.53e-11

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 56.10  E-value: 9.53e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 85702209      5 SRRPHTGLTLSQRRILAQAFERNPRPGCATREELALETGLPEDMIHTWLKNK 56
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNR 52
Homeodomain pfam00046
Homeodomain;
6-56 5.27e-09

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 51.35  E-value: 5.27e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 85702209     6 RRPHTGLTLSQRRILAQAFERNPRPGCATREELALETGLPEDMIHTWLKNK 56
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNR 51
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
2-56 1.36e-06

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 47.05  E-value: 1.36e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 85702209   2 RSSSRRPHTGLTLSQRRILAQAFERNPRPGCATREELALETGLPEDMIHTWLKNK 56
Cdd:COG5576  48 SSPPKSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNK 102
 
Name Accession Description Interval E-value
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 6-56 2.60e-11

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 58.02  E-value: 2.60e-11
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 85702209   6 RRPHTGLTLSQRRILAQAFERNPRPGCATREELALETGLPEDMIHTWLKNK 56
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNR 51
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 5-56 9.53e-11

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 56.10  E-value: 9.53e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 85702209      5 SRRPHTGLTLSQRRILAQAFERNPRPGCATREELALETGLPEDMIHTWLKNK 56
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNR 52
Homeodomain pfam00046
Homeodomain;
6-56 5.27e-09

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 51.35  E-value: 5.27e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 85702209     6 RRPHTGLTLSQRRILAQAFERNPRPGCATREELALETGLPEDMIHTWLKNK 56
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNR 51
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
2-56 1.36e-06

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 47.05  E-value: 1.36e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 85702209   2 RSSSRRPHTGLTLSQRRILAQAFERNPRPGCATREELALETGLPEDMIHTWLKNK 56
Cdd:COG5576  48 SSPPKSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNK 102
CENP-B_N pfam04218
CENP-B N-terminal DNA-binding domain; Centromere Protein B (CENP-B) is a DNA-binding protein ...
 6-56 7.19e-03

CENP-B N-terminal DNA-binding domain; Centromere Protein B (CENP-B) is a DNA-binding protein localized to the centromere. Within the N-terminal 125 residues, there is a DNA-binding region, which binds to a corresponding 17bp CENP-B box sequence. CENP-B dimers either bind two separate DNA molecules or alternatively, they may bind two CENP-B boxes on one DNA molecule, with the intervening stretch of DNA forming a loop structure. The CENP-B DNA-binding domain consists of two repeating domains, RP1 and RP2. This family corresponds to RP1 has been shown to consist of four helices in a helix-turn-helix structure.


Pssm-ID: 461229  Cd Length: 53  Bit Score: 33.92  E-value: 7.19e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 85702209     6 RRPHTGLTLSQRRILAQAFERNPRpgcatREELALETGLPEDMIHTWLKNK 56
Cdd:pfam04218   1 RRKRRSLTLREKIAIIQRYEEGES-----KASLARRFGVPASTLRRILKNK 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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