NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2175849829|ref|NP_001030098|]
View 

leucine-rich repeat-containing protein 40 isoform 1 [Rattus norvegicus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 12835115)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
68-322 7.55e-35

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 136.60  E-value: 7.55e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829  68 QNLSFSSTERWWEQTDLTKLIISSNKLQSLSDDLRLLPALTVLDIHDNQLTSLPSAIRELDNLQKLNVSHNKLKMLPEEI 147
Cdd:COG4886    99 TELDLSGNEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEEL 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 148 TSLKNLKALHLQHNELTCIPEGFEHLSSLEDLDLSSNrlatvpadfallsnllrlnlssnQLKNLPAEISRMKRLKHLDC 227
Cdd:COG4886   179 GNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGN-----------------------QLTDLPEPLANLTNLETLDL 235

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 228 DANLLETVpPDVGSMESLELLYLRRNKLRVLPEFPSCRQLKELYLAENQIEKLGAEHLQHLQAILVLDLRSNKLRSVPEE 307
Cdd:COG4886   236 SNNQLTDL-PELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELL 314

                         250
                  ....*....|....*
gi 2175849829 308 MALLQSLERLDLSNN 322
Cdd:COG4886   315 ILLLLLTTLLLLLLL 329
PLN00113 super family cl33413
leucine-rich repeat receptor-like protein kinase; Provisional
 89-577 3.26e-22

leucine-rich repeat receptor-like protein kinase; Provisional


The actual alignment was detected with superfamily member PLN00113:

Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 101.46  E-value: 3.26e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829  89 ISSNKLQ-SLSDDL-RLLPALTVLDIHDNQLT-SLPSAirELDNLQKLNVSHNKLK-MLPEEITSLKNLKALHLQHNELT 164
Cdd:PLN00113  100 LSNNQLSgPIPDDIfTTSSSLRYLNLSNNNFTgSIPRG--SIPNLETLDLSNNMLSgEIPNDIGSFSSLKVLDLGGNVLV 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 165 C-IPEGFEHLSSLEDLDLSSNRL-ATVPADFALLSNLLRLNLSSNQLK-NLPAEISRMKRLKHLD-CDANLLETVPPDVG 240
Cdd:PLN00113  178 GkIPNSLTNLTSLEFLTLASNQLvGQIPRELGQMKSLKWIYLGYNNLSgEIPYEIGGLTSLNHLDlVYNNLTGPIPSSLG 257

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 241 SMESLELLYLRRNKLrvlpefpscrqlkelylaENQIEKlgaeHLQHLQAILVLDLRSNKLR-SVPEEMALLQSLERLDL 319
Cdd:PLN00113  258 NLKNLQYLFLYQNKL------------------SGPIPP----SIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILHL 315

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 320 -SNNDISSLPCSLGNL-HLKFLALEGNPLRtirreiiakgtqevlkylrSKIKDDRTNQNDsvpetamtlpsearvniha 397
Cdd:PLN00113  316 fSNNFTGKIPVALTSLpRLQVLQLWSNKFS-------------------GEIPKNLGKHNN------------------- 357

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 398 ivtLKLLDYSDKQAT-LIPDDIFDATKNTVVtsINFSKNQLCEIPQRIAELKEMVlDVNLSFNKLS-LVSHELCLLQKLA 475
Cdd:PLN00113  358 ---LTVLDLSTNNLTgEIPEGLCSSGNLFKL--ILFSNSLEGEIPKSLGACRSLR-RVRLQDNSFSgELPSEFTKLPLVY 431

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 476 FLDLR-NNFLSSLPEEMSSLTKLQTINLSFNRFKVFPAVLYHISTLETILISNNQVGSVDPLKMKLMENLSTLDLQNNDL 554
Cdd:PLN00113  432 FLDISnNNLQGRINSRKWDMPSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKL 511

                         490       500
                  ....*....|....*....|....
gi 2175849829 555 L-QIPPELGNCVQLRTLLLDGNPF 577
Cdd:PLN00113  512 SgEIPDELSSCKKLVSLDLSHNQL 535
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
68-322 7.55e-35

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 136.60  E-value: 7.55e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829  68 QNLSFSSTERWWEQTDLTKLIISSNKLQSLSDDLRLLPALTVLDIHDNQLTSLPSAIRELDNLQKLNVSHNKLKMLPEEI 147
Cdd:COG4886    99 TELDLSGNEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEEL 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 148 TSLKNLKALHLQHNELTCIPEGFEHLSSLEDLDLSSNrlatvpadfallsnllrlnlssnQLKNLPAEISRMKRLKHLDC 227
Cdd:COG4886   179 GNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGN-----------------------QLTDLPEPLANLTNLETLDL 235

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 228 DANLLETVpPDVGSMESLELLYLRRNKLRVLPEFPSCRQLKELYLAENQIEKLGAEHLQHLQAILVLDLRSNKLRSVPEE 307
Cdd:COG4886   236 SNNQLTDL-PELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELL 314

                         250
                  ....*....|....*
gi 2175849829 308 MALLQSLERLDLSNN 322
Cdd:COG4886   315 ILLLLLTTLLLLLLL 329
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 89-577 3.26e-22

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 101.46  E-value: 3.26e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829  89 ISSNKLQ-SLSDDL-RLLPALTVLDIHDNQLT-SLPSAirELDNLQKLNVSHNKLK-MLPEEITSLKNLKALHLQHNELT 164
Cdd:PLN00113  100 LSNNQLSgPIPDDIfTTSSSLRYLNLSNNNFTgSIPRG--SIPNLETLDLSNNMLSgEIPNDIGSFSSLKVLDLGGNVLV 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 165 C-IPEGFEHLSSLEDLDLSSNRL-ATVPADFALLSNLLRLNLSSNQLK-NLPAEISRMKRLKHLD-CDANLLETVPPDVG 240
Cdd:PLN00113  178 GkIPNSLTNLTSLEFLTLASNQLvGQIPRELGQMKSLKWIYLGYNNLSgEIPYEIGGLTSLNHLDlVYNNLTGPIPSSLG 257

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 241 SMESLELLYLRRNKLrvlpefpscrqlkelylaENQIEKlgaeHLQHLQAILVLDLRSNKLR-SVPEEMALLQSLERLDL 319
Cdd:PLN00113  258 NLKNLQYLFLYQNKL------------------SGPIPP----SIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILHL 315

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 320 -SNNDISSLPCSLGNL-HLKFLALEGNPLRtirreiiakgtqevlkylrSKIKDDRTNQNDsvpetamtlpsearvniha 397
Cdd:PLN00113  316 fSNNFTGKIPVALTSLpRLQVLQLWSNKFS-------------------GEIPKNLGKHNN------------------- 357

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 398 ivtLKLLDYSDKQAT-LIPDDIFDATKNTVVtsINFSKNQLCEIPQRIAELKEMVlDVNLSFNKLS-LVSHELCLLQKLA 475
Cdd:PLN00113  358 ---LTVLDLSTNNLTgEIPEGLCSSGNLFKL--ILFSNSLEGEIPKSLGACRSLR-RVRLQDNSFSgELPSEFTKLPLVY 431

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 476 FLDLR-NNFLSSLPEEMSSLTKLQTINLSFNRFKVFPAVLYHISTLETILISNNQVGSVDPLKMKLMENLSTLDLQNNDL 554
Cdd:PLN00113  432 FLDISnNNLQGRINSRKWDMPSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKL 511

                         490       500
                  ....*....|....*....|....
gi 2175849829 555 L-QIPPELGNCVQLRTLLLDGNPF 577
Cdd:PLN00113  512 SgEIPDELSSCKKLVSLDLSHNQL 535
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
395-577 2.05e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 93.84  E-value: 2.05e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 395 IHAIVTLKLLDYSDKQATLIPDDIFDATKntvVTSINFSKNQLCEIPQRIAELKEMVlDVNLSFNKLSLVSHELCLLQKL 474
Cdd:COG4886   109 LSNLTNLESLDLSGNQLTDLPEELANLTN---LKELDLSNNQLTDLPEPLGNLTNLK-SLDLSNNQLTDLPEELGNLTNL 184

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 475 AFLDLRNNFLSSLPEEMSSLTKLQTINLSFNRFKVFPAVLYHISTLETILISNNQVGSVDPLKmkLMENLSTLDLQNNDL 554
Cdd:COG4886   185 KELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELG--NLTNLEELDLSNNQL 262

                         170       180
                  ....*....|....*....|...
gi 2175849829 555 LQIPPeLGNCVQLRTLLLDGNPF 577
Cdd:COG4886   263 TDLPP-LANLTNLKTLDLSNNQL 284
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 120-577 6.56e-19

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 91.06  E-value: 6.56e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 120 LPSAIRELDNLQKLNVSHNKLK-MLPEEI-TSLKNLKALHLQHNELT-CIPEGFehLSSLEDLDLSSNRLAtvpadfall 196
Cdd:PLN00113   85 ISSAIFRLPYIQTINLSNNQLSgPIPDDIfTTSSSLRYLNLSNNNFTgSIPRGS--IPNLETLDLSNNMLS--------- 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 197 snllrlnlssnqlKNLPAEISRMKRLKHLDCDANLLE-TVPPDVGSMESLELLYLRRNKL--RVLPEFPSCRQLKELYLA 273
Cdd:PLN00113  154 -------------GEIPNDIGSFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQLvgQIPRELGQMKSLKWIYLG 220

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 274 ENQiekLGAEhlqhlqailvldlrsnklrsVPEEMALLQSLERLDLS-NNDISSLPCSLGNL-HLKFLALegnplrtirr 351
Cdd:PLN00113  221 YNN---LSGE--------------------IPYEIGGLTSLNHLDLVyNNLTGPIPSSLGNLkNLQYLFL---------- 267

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 352 eiiakgtqevlkylrskikddrtnqndsvpetamtlpsearvnihaivtlklldYSDKQATLIPDDIFDATKntvVTSIN 431
Cdd:PLN00113  268 ------------------------------------------------------YQNKLSGPIPPSIFSLQK---LISLD 290

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 432 FSKNQLC-EIPQRIAELKEMVLdvnlsfnkLSLVShelcllqklafldlrNNFLSSLPEEMSSLTKLQTINLSFNRFK-V 509
Cdd:PLN00113  291 LSDNSLSgEIPELVIQLQNLEI--------LHLFS---------------NNFTGKIPVALTSLPRLQVLQLWSNKFSgE 347

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2175849829 510 FPAVLYHISTLETILISNNQVGSVDPLKMKLMENLSTLDLQNNDLL-QIPPELGNCVQLRTLLLDGNPF 577
Cdd:PLN00113  348 IPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEgEIPKSLGACRSLRRVRLQDNSF 416
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 145-355 1.26e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 70.20  E-value: 1.26e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 145 EEITSLKNLKALHLQHNELTCIpEGFEHLSSLEDLDLSSNRlatvpadfallsnllrlnlssnqlknlpaeISRMKRLKH 224
Cdd:cd21340    18 DNLSLCKNLKVLYLYDNKITKI-ENLEFLTNLTHLYLQNNQ------------------------------IEKIENLEN 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 225 LdcdanlletvppdvgsmESLELLYLRRNKLRVLPEFPSCRQLKELYLaENQieKLGAEH--------LQHLQAIL-VLD 295
Cdd:cd21340    67 L-----------------VNLKKLYLGGNRISVVEGLENLTNLEELHI-ENQ--RLPPGEkltfdprsLAALSNSLrVLN 126

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2175849829 296 LRSNKLRSVpEEMALLQSLERLDLSNNDISSLP---CSLGNL-HLKFLALEGNPLRTIRR---EIIA 355
Cdd:cd21340   127 ISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEellDLLSSWpSLRELDLTGNPVCKKPKyrdKIIL 192
LRR_8 pfam13855
Leucine rich repeat;
129-186 7.94e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.14  E-value: 7.94e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 129 NLQKLNVSHNKLKMLPEEI-TSLKNLKALHLQHNELTCI-PEGFEHLSSLEDLDLSSNRL 186
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 471-577 5.95e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.78  E-value: 5.95e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 471 LQKLAFLDLRNNFLSSLpEEMSSLTKLQTINLSFNRFKV---------------------------F-PAVLYHIS-TLE 521
Cdd:cd21340    45 LTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLGGNRISVveglenltnleelhienqrlppgekltFdPRSLAALSnSLR 123

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2175849829 522 TILISNNQVGSVDPLKmkLMENLSTLDLQNN---DLLQIPPELGNCVQLRTLLLDGNPF 577
Cdd:cd21340   124 VLNISGNNIDSLEPLA--PLRNLEQLDASNNqisDLEELLDLLSSWPSLRELDLTGNPV 180
LRR_8 pfam13855
Leucine rich repeat;
518-577 4.75e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.58  E-value: 4.75e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2175849829 518 STLETILISNNQVGSVDPLKMKLMENLSTLDLQNNDLLQIPPE-LGNCVQLRTLLLDGNPF 577
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
68-322 7.55e-35

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 136.60  E-value: 7.55e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829  68 QNLSFSSTERWWEQTDLTKLIISSNKLQSLSDDLRLLPALTVLDIHDNQLTSLPSAIRELDNLQKLNVSHNKLKMLPEEI 147
Cdd:COG4886    99 TELDLSGNEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEEL 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 148 TSLKNLKALHLQHNELTCIPEGFEHLSSLEDLDLSSNrlatvpadfallsnllrlnlssnQLKNLPAEISRMKRLKHLDC 227
Cdd:COG4886   179 GNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGN-----------------------QLTDLPEPLANLTNLETLDL 235

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 228 DANLLETVpPDVGSMESLELLYLRRNKLRVLPEFPSCRQLKELYLAENQIEKLGAEHLQHLQAILVLDLRSNKLRSVPEE 307
Cdd:COG4886   236 SNNQLTDL-PELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELL 314

                         250
                  ....*....|....*
gi 2175849829 308 MALLQSLERLDLSNN 322
Cdd:COG4886   315 ILLLLLTTLLLLLLL 329
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
67-346 1.76e-34

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 135.45  E-value: 1.76e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829  67 NQNLSFSSTERWWEQTDLTKLIISSNklqslsDDLRLLPALTVLDIHDNQLTSLPSAIRELDNLQKLNVSHNKLKMLPEE 146
Cdd:COG4886    81 LLSLLLLGLTDLGDLTNLTELDLSGN------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEP 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 147 ITSLKNLKALHLQHNELTCIPEGFEHLSSLEDLDLSSNrlatvpadfallsnllrlnlssnQLKNLPAEISRMKRLKHLD 226
Cdd:COG4886   155 LGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNN-----------------------QITDLPEPLGNLTNLEELD 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 227 CDANLLETVPPDVGSMESLELLYLRRNKLRVLPEFPSCRQLKELYLAENQIEKLGaeHLQHLQAILVLDLRSNKLRSVPE 306
Cdd:COG4886   212 LSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQLTDLKL 289

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 2175849829 307 EMALLQSLERLDLSNNDISSLPCSLGNLHLKFLALEGNPL 346
Cdd:COG4886   290 KELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLL 329
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
69-327 4.32e-32

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 128.51  E-value: 4.32e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829  69 NLSFSSTERWWEQTDLTKLIISSNKLQSLSDDLRLLPALTVLDIHDNQltslpsAIRELDNLQKLNVSHNKLKMLPEEIT 148
Cdd:COG4886    60 LLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEELA 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 149 SLKNLKALHLQHNELTCIPEGFEHLSSLEDLDLSSNrlatvpadfallsnllrlnlssnQLKNLPAEISRMKRLKHLDCD 228
Cdd:COG4886   134 NLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNN-----------------------QLTDLPEELGNLTNLKELDLS 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 229 ANLLETVPPDVGSMESLELLYLRRNKLRVLP-EFPSCRQLKELYLAENQIEKLgaEHLQHLQAILVLDLRSNKLRSVPEE 307
Cdd:COG4886   191 NNQITDLPEPLGNLTNLEELDLSGNQLTDLPePLANLTNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQLTDLPPL 268

                         250       260
                  ....*....|....*....|
gi 2175849829 308 MAlLQSLERLDLSNNDISSL 327
Cdd:COG4886   269 AN-LTNLKTLDLSNNQLTDL 287
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
79-365 4.53e-28

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 116.96  E-value: 4.53e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829  79 WEQTDLTKLIISSNKLQSLSDDLRLLPALTVLDIHDNQLTSLPSAIRELDNLQKLNVSHNKLKMLPEEITSLKNLKALHL 158
Cdd:COG4886    24 LILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDL 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 159 QHNeltcipEGFEHLSSLEDLDLSSNRLATVPADFALLSNLLRLNLSSNQLKNLPAEISRMKRLKHLDCDANLLETVPPD 238
Cdd:COG4886   104 SGN------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEE 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 239 VGSMESLELLYLRRNKLRVLP-EFPSCRQLKELYLAENQIEKLGAEhLQHLQAILVLDLRSNKLRSVPeEMALLQSLERL 317
Cdd:COG4886   178 LGNLTNLKELDLSNNQITDLPePLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLTDLP-ELGNLTNLEEL 255

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 2175849829 318 DLSNNDISSLPCSLGNLHLKFLALEGNPLRTIRREIIAKGTQEVLKYL 365
Cdd:COG4886   256 DLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLL 303
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 89-577 3.26e-22

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 101.46  E-value: 3.26e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829  89 ISSNKLQ-SLSDDL-RLLPALTVLDIHDNQLT-SLPSAirELDNLQKLNVSHNKLK-MLPEEITSLKNLKALHLQHNELT 164
Cdd:PLN00113  100 LSNNQLSgPIPDDIfTTSSSLRYLNLSNNNFTgSIPRG--SIPNLETLDLSNNMLSgEIPNDIGSFSSLKVLDLGGNVLV 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 165 C-IPEGFEHLSSLEDLDLSSNRL-ATVPADFALLSNLLRLNLSSNQLK-NLPAEISRMKRLKHLD-CDANLLETVPPDVG 240
Cdd:PLN00113  178 GkIPNSLTNLTSLEFLTLASNQLvGQIPRELGQMKSLKWIYLGYNNLSgEIPYEIGGLTSLNHLDlVYNNLTGPIPSSLG 257

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 241 SMESLELLYLRRNKLrvlpefpscrqlkelylaENQIEKlgaeHLQHLQAILVLDLRSNKLR-SVPEEMALLQSLERLDL 319
Cdd:PLN00113  258 NLKNLQYLFLYQNKL------------------SGPIPP----SIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILHL 315

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 320 -SNNDISSLPCSLGNL-HLKFLALEGNPLRtirreiiakgtqevlkylrSKIKDDRTNQNDsvpetamtlpsearvniha 397
Cdd:PLN00113  316 fSNNFTGKIPVALTSLpRLQVLQLWSNKFS-------------------GEIPKNLGKHNN------------------- 357

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 398 ivtLKLLDYSDKQAT-LIPDDIFDATKNTVVtsINFSKNQLCEIPQRIAELKEMVlDVNLSFNKLS-LVSHELCLLQKLA 475
Cdd:PLN00113  358 ---LTVLDLSTNNLTgEIPEGLCSSGNLFKL--ILFSNSLEGEIPKSLGACRSLR-RVRLQDNSFSgELPSEFTKLPLVY 431

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 476 FLDLR-NNFLSSLPEEMSSLTKLQTINLSFNRFKVFPAVLYHISTLETILISNNQVGSVDPLKMKLMENLSTLDLQNNDL 554
Cdd:PLN00113  432 FLDISnNNLQGRINSRKWDMPSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKL 511

                         490       500
                  ....*....|....*....|....
gi 2175849829 555 L-QIPPELGNCVQLRTLLLDGNPF 577
Cdd:PLN00113  512 SgEIPDELSSCKKLVSLDLSHNQL 535
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
395-577 2.05e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 93.84  E-value: 2.05e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 395 IHAIVTLKLLDYSDKQATLIPDDIFDATKntvVTSINFSKNQLCEIPQRIAELKEMVlDVNLSFNKLSLVSHELCLLQKL 474
Cdd:COG4886   109 LSNLTNLESLDLSGNQLTDLPEELANLTN---LKELDLSNNQLTDLPEPLGNLTNLK-SLDLSNNQLTDLPEELGNLTNL 184

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 475 AFLDLRNNFLSSLPEEMSSLTKLQTINLSFNRFKVFPAVLYHISTLETILISNNQVGSVDPLKmkLMENLSTLDLQNNDL 554
Cdd:COG4886   185 KELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELG--NLTNLEELDLSNNQL 262

                         170       180
                  ....*....|....*....|...
gi 2175849829 555 LQIPPeLGNCVQLRTLLLDGNPF 577
Cdd:COG4886   263 TDLPP-LANLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
314-578 4.52e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 93.07  E-value: 4.52e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 314 LERLDLSNNDISSLPCSLGNLHLKFLALEGNPLRTIRREIIAKGTQEVLKYLRSKIKDDRTNQNDSVPETAMTLPSEARV 393
Cdd:COG4886     2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 394 NIHAIVTLKLLDYSDKQATLIPDDIFDATKNTVVTSINFSKNQLCEIPQRIAELKEMVlDVNLSFNKLSLVSHELCLLQK 473
Cdd:COG4886    82 LSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELANLTNLK-ELDLSNNQLTDLPEPLGNLTN 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 474 LAFLDLRNNFLSSLPEEMSSLTKLQTINLSFNRFKVFPAVLYHISTLETILISNNQVGSVdPLKMKLMENLSTLDLQNND 553
Cdd:COG4886   161 LKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQ 239

                         250       260
                  ....*....|....*....|....*
gi 2175849829 554 LLQIpPELGNCVQLRTLLLDGNPFR 578
Cdd:COG4886   240 LTDL-PELGNLTNLEELDLSNNQLT 263
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 120-577 6.56e-19

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 91.06  E-value: 6.56e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 120 LPSAIRELDNLQKLNVSHNKLK-MLPEEI-TSLKNLKALHLQHNELT-CIPEGFehLSSLEDLDLSSNRLAtvpadfall 196
Cdd:PLN00113   85 ISSAIFRLPYIQTINLSNNQLSgPIPDDIfTTSSSLRYLNLSNNNFTgSIPRGS--IPNLETLDLSNNMLS--------- 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 197 snllrlnlssnqlKNLPAEISRMKRLKHLDCDANLLE-TVPPDVGSMESLELLYLRRNKL--RVLPEFPSCRQLKELYLA 273
Cdd:PLN00113  154 -------------GEIPNDIGSFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQLvgQIPRELGQMKSLKWIYLG 220

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 274 ENQiekLGAEhlqhlqailvldlrsnklrsVPEEMALLQSLERLDLS-NNDISSLPCSLGNL-HLKFLALegnplrtirr 351
Cdd:PLN00113  221 YNN---LSGE--------------------IPYEIGGLTSLNHLDLVyNNLTGPIPSSLGNLkNLQYLFL---------- 267

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 352 eiiakgtqevlkylrskikddrtnqndsvpetamtlpsearvnihaivtlklldYSDKQATLIPDDIFDATKntvVTSIN 431
Cdd:PLN00113  268 ------------------------------------------------------YQNKLSGPIPPSIFSLQK---LISLD 290

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 432 FSKNQLC-EIPQRIAELKEMVLdvnlsfnkLSLVShelcllqklafldlrNNFLSSLPEEMSSLTKLQTINLSFNRFK-V 509
Cdd:PLN00113  291 LSDNSLSgEIPELVIQLQNLEI--------LHLFS---------------NNFTGKIPVALTSLPRLQVLQLWSNKFSgE 347

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2175849829 510 FPAVLYHISTLETILISNNQVGSVDPLKMKLMENLSTLDLQNNDLL-QIPPELGNCVQLRTLLLDGNPF 577
Cdd:PLN00113  348 IPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEgEIPKSLGACRSLRRVRLQDNSF 416
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
166-563 8.56e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 83.06  E-value: 8.56e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 166 IPEGFEHLSSLEDLDLSSNRLATVPADFALLSNLLRLNLSSNQLKNLPAEISRMKRLKHLDCDANLLETVPPDVGSMESL 245
Cdd:COG4886    14 LLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLG 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 246 ELLYLRRNKLRVLPEFPSCRQLKELYLAENQIEKLGAEhLQHLQAILVLDLRSNKLRSVPEEMALLQSLERLDLSNNDIS 325
Cdd:COG4886    94 DLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLT 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 326 SLPCSLGNL-HLKFLALEGNPLRTIRREIiakgtqevlkylrskikddrtnqndsvpetamtlpsearvnihaivtlkll 404
Cdd:COG4886   173 DLPEELGNLtNLKELDLSNNQITDLPEPL--------------------------------------------------- 201

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 405 dysdkqatlipddifdaTKNTVVTSINFSKNQLCEIPQRIAELKEMVLdVNLSFNKLSLVShELCLLQKLAFLDLRNNFL 484
Cdd:COG4886   202 -----------------GNLTNLEELDLSGNQLTDLPEPLANLTNLET-LDLSNNQLTDLP-ELGNLTNLEELDLSNNQL 262

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2175849829 485 SSLPEEmSSLTKLQTINLSFNRFKVFpAVLYHISTLETILISNNQVGSVDPLKMKLMENLSTLDLQNNDLLQIPPELGN 563
Cdd:COG4886   263 TDLPPL-ANLTNLKTLDLSNNQLTDL-KLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTT 339
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
84-290 1.30e-14

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 77.04  E-value: 1.30e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829  84 LTKLIISSNKLQSLSDDLRllPALTVLDIHDNQLTS----LPSAIRELD---------------NLQKLNVSHNKLKMLP 144
Cdd:PRK15370  201 ITTLILDNNELKSLPENLQ--GNIKTLYANSNQLTSipatLPDTIQEMElsinritelperlpsALQSLDLFHNKISCLP 278

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 145 EEITslKNLKALHLQHNELTCIPegfEHL-SSLEDLDLSSNRLATVPADFALLSNLLRLNLSSnqLKNLPAEISrmKRLK 223
Cdd:PRK15370  279 ENLP--EELRYLSVYDNSIRTLP---AHLpSGITHLNVQSNSLTALPETLPPGLKTLEAGENA--LTSLPASLP--PELQ 349

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2175849829 224 HLDCDAN----LLETVPPdvgsmeSLELLYLRRNKLRVLPE-FPSCrqLKELYLAENQIEKLgAEHLQHLQA 290
Cdd:PRK15370  350 VLDVSKNqitvLPETLPP------TITTLDVSRNALTNLPEnLPAA--LQIMQASRNNLVRL-PESLPHFRG 412
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 83-343 4.62e-14

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 75.65  E-value: 4.62e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829  83 DLTKLI---ISSNKLQSLSDDLRL-LPALTVLDIHDNQLT-SLPSAIRELDNLQKLNVSHNKLK-MLPEEITSLKNLKAL 156
Cdd:PLN00113  282 SLQKLIsldLSDNSLSGEIPELVIqLQNLEILHLFSNNFTgKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVL 361

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 157 HLQHNELTC-IPEGFEHLSSLEDLDLSSNRL-ATVPADFALLSNLLRLNLSSNQLK-NLPAEISRMKRLKHLD-CDANLL 232
Cdd:PLN00113  362 DLSTNNLTGeIPEGLCSSGNLFKLILFSNSLeGEIPKSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDiSNNNLQ 441

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 233 ETVPPDVGSMESLELLYLRRNK-LRVLPEFPSCRQLKELYLAENQIEKLGAEHLQHLQAILVLDLRSNKLRSV-PEEMAL 310
Cdd:PLN00113  442 GRINSRKWDMPSLQMLSLARNKfFGGLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEiPDELSS 521

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 2175849829 311 LQSLERLDLSNNDIS-SLPCS------LGNLHLKFLALEG 343
Cdd:PLN00113  522 CKKLVSLDLSHNQLSgQIPASfsempvLSQLDLSQNQLSG 561
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 145-355 1.26e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 70.20  E-value: 1.26e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 145 EEITSLKNLKALHLQHNELTCIpEGFEHLSSLEDLDLSSNRlatvpadfallsnllrlnlssnqlknlpaeISRMKRLKH 224
Cdd:cd21340    18 DNLSLCKNLKVLYLYDNKITKI-ENLEFLTNLTHLYLQNNQ------------------------------IEKIENLEN 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 225 LdcdanlletvppdvgsmESLELLYLRRNKLRVLPEFPSCRQLKELYLaENQieKLGAEH--------LQHLQAIL-VLD 295
Cdd:cd21340    67 L-----------------VNLKKLYLGGNRISVVEGLENLTNLEELHI-ENQ--RLPPGEkltfdprsLAALSNSLrVLN 126

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2175849829 296 LRSNKLRSVpEEMALLQSLERLDLSNNDISSLP---CSLGNL-HLKFLALEGNPLRTIRR---EIIA 355
Cdd:cd21340   127 ISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEellDLLSSWpSLRELDLTGNPVCKKPKyrdKIIL 192
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 32-192 4.30e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 69.11  E-value: 4.30e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829  32 LKAARSSGQLNLAGRNL-GEVPQCVWRIN-VDIPEEANQNLSFSSTERWWEQTDLTKLIISSNKLQSLSDDLRLLPALTV 109
Cdd:PLN00113  400 LGACRSLRRVRLQDNSFsGELPSEFTKLPlVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGGLPDSFGSKRLEN 479

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 110 LDIHDNQLT-SLPSAIRELDNLQKLNVSHNKLK-MLPEEITSLKNLKALHLQHNELTC-IPEGFEHLSSLEDLDLSSNRL 186
Cdd:PLN00113  480 LDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLSGqIPASFSEMPVLSQLDLSQNQL 559


                  ....*..
gi 2175849829 187 A-TVPAD 192
Cdd:PLN00113  560 SgEIPKN 566
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
209-494 9.08e-12

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 68.18  E-value: 9.08e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 209 LKNLPAEIsRMKRLKhldcdanlLETVPPDVGsmESLELLYLRRNKLRVLPEFPSCrQLKELYLAENQIEKLGAEHLQHL 288
Cdd:PRK15370  176 LKNNKTEL-RLKILG--------LTTIPACIP--EQITTLILDNNELKSLPENLQG-NIKTLYANSNQLTSIPATLPDTI 243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 289 QailVLDLRSNKLRSVPEEmaLLQSLERLDLSNNDISSLPCSLGNlHLKFLALEGNPLRTIRreiiakgtqevlKYLRSK 368
Cdd:PRK15370  244 Q---EMELSINRITELPER--LPSALQSLDLFHNKISCLPENLPE-ELRYLSVYDNSIRTLP------------AHLPSG 305

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 369 IKDDRTnQNDSVPETAMTLPsearvnihaiVTLKLLDYSDKQATLIPDDIFDATKNtvvtsINFSKNQLCEIPQRI-AEL 447
Cdd:PRK15370  306 ITHLNV-QSNSLTALPETLP----------PGLKTLEAGENALTSLPASLPPELQV-----LDVSKNQITVLPETLpPTI 369

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 2175849829 448 KEMVLDVNLsfnklsLVSHELCLLQKLAFLDLRNNFLSSLPEEMSSL 494
Cdd:PRK15370  370 TTLDVSRNA------LTNLPENLPAALQIMQASRNNLVRLPESLPHF 410
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
87-355 1.55e-11

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 67.49  E-value: 1.55e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829  87 LIISSNKLQSLSDdlrLLPA-LTVLDIHDNQLTSLPSAIRELDNLQklnVSHNKLKMLPEEITSLKNLKALHLQHNELTC 165
Cdd:PRK15387  206 LNVGESGLTTLPD---CLPAhITTLVIPDNNLTSLPALPPELRTLE---VSGNQLTSLPVLPPGLLELSIFSNPLTHLPA 279

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 166 IPEGF-------EHLSS-------LEDLDLSSNRLATVPadfALLSNLLRLNLSSNQLKNLPAEISRMKRLKHLDCDANL 231
Cdd:PRK15387  280 LPSGLcklwifgNQLTSlpvlppgLQELSVSDNQLASLP---ALPSELCKLWAYNNQLTSLPTLPSGLQELSVSDNQLAS 356

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 232 LETVPPDvgsmesLELLYLRRNKLRVLPEFPScrQLKELYLAENQIEKLGAEHlQHLQAILVldlRSNKLRSVPeemALL 311
Cdd:PRK15387  357 LPTLPSE------LYKLWAYNNRLTSLPALPS--GLKELIVSGNRLTSLPVLP-SELKELMV---SGNRLTSLP---MLP 421

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2175849829 312 QSLERLDLSNNDISSLPCSLgnLHLK---FLALEGNPL--RTIR--REIIA 355
Cdd:PRK15387  422 SGLLSLSVYRNQLTRLPESL--IHLSsetTVNLEGNPLseRTLQalREITS 470
LRR_8 pfam13855
Leucine rich repeat;
129-186 7.94e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.14  E-value: 7.94e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 129 NLQKLNVSHNKLKMLPEEI-TSLKNLKALHLQHNELTCI-PEGFEHLSSLEDLDLSSNRL 186
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 101-317 5.12e-08

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 55.57  E-value: 5.12e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 101 LRLLPALTVLDIHDNQLT-----SLPSAIRELDNLQKLNVSHNKL-----KMLPEEITSLKNLKALHLQHNELT-----C 165
Cdd:COG5238   232 LKGNKSLTTLDLSNNQIGdegviALAEALKNNTTVETLYLSGNQIgaegaIALAKALQGNTTLTSLDLSVNRIGdegaiA 311

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 166 IPEGFEHLSSLEDLDLSSNRLATVPADFallsnllrlnlssnqlknLPAEISRMKRLKHLDCDANLLetvppdvgSMESL 245
Cdd:COG5238   312 LAEGLQGNKTLHTLNLAYNGIGAQGAIA------------------LAKALQENTTLHSLDLSDNQI--------GDEGA 365

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2175849829 246 ELL--YLRRNKlrvlpefpscrQLKELYLAENQIEKLGAEHL-QHLQAILV--LDLRSNKLRSVPEEmALLQSLERL 317
Cdd:COG5238   366 IALakYLEGNT-----------TLRELNLGKNNIGKQGAEALiDALQTNRLhtLILDGNLIGAEAQQ-RLEQLLERI 430
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 103-342 9.31e-08

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 55.27  E-value: 9.31e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829  103 LLPALTVLDIHDNQLTSLPSAIRElDNLQKLNVSHNKLKMLPEEITSLKNLKALHLQhneltcipeGFEHLSSLEDLDLS 182
Cdd:PLN03210   587 LPPKLRLLRWDKYPLRCMPSNFRP-ENLVKLQMQGSKLEKLWDGVHSLTGLRNIDLR---------GSKNLKEIPDLSMA 656

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829  183 SNrlatvpadfallsnLLRLNLSS-NQLKNLPAEISRMKRLKHLD---CDAnlLETVPPDVgSMESLELLYLRR-NKLRV 257
Cdd:PLN03210   657 TN--------------LETLKLSDcSSLVELPSSIQYLNKLEDLDmsrCEN--LEILPTGI-NLKSLYRLNLSGcSRLKS 719

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829  258 LPEFPScrQLKELYLAENQIEKLGAE-HLQHLQAILVLDLRSNKL--RSVPEE--MALLQ-SLERLDLSNN-DISSLPCS 330
Cdd:PLN03210   720 FPDIST--NISWLDLDETAIEEFPSNlRLENLDELILCEMKSEKLweRVQPLTplMTMLSpSLTRLFLSDIpSLVELPSS 797

                          250
                   ....*....|...
gi 2175849829  331 LGNLH-LKFLALE 342
Cdd:PLN03210   798 IQNLHkLEHLEIE 810
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 414-580 9.39e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 55.24  E-value: 9.39e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 414 IPDDIFdaTKNTVVTSINFSKNQLC-EIPQRIAELKEMVldvNLSFNKLS-LVSHELCLLQKLAFLDLRNNFLSS-LPEE 490
Cdd:PLN00113  109 IPDDIF--TTSSSLRYLNLSNNNFTgSIPRGSIPNLETL---DLSNNMLSgEIPNDIGSFSSLKVLDLGGNVLVGkIPNS 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 491 MSSLTKLQTINLSFNRF-KVFPAVLYHISTLETILISNNQVGSVDPLKMKLMENLSTLDLQNNDLL-QIPPELGNCVQLR 568
Cdd:PLN00113  184 LTNLTSLEFLTLASNQLvGQIPRELGQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTgPIPSSLGNLKNLQ 263

                         170
                  ....*....|..
gi 2175849829 569 TLLLDGNPFRVP 580
Cdd:PLN00113  264 YLFLYQNKLSGP 275
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 101-368 1.36e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 53.51  E-value: 1.36e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 101 LRLLPALTVLDIHDNQLTS-----LPSAIRELDNLQKLNVSHNKLKM-------LPEEITSLKNLKALHLQHNELTC--- 165
Cdd:cd00116    19 LPKLLCLQVLRLEGNTLGEeaakaLASALRPQPSLKELCLSLNETGRiprglqsLLQGLTKGCGLQELDLSDNALGPdgc 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 166 -IPEGFEHLSSLEDLDLSSNRLATVPADFallsnllrlnlSSNQLKNLPAeisrmkRLKHLDCDANLLEtvppdVGSMES 244
Cdd:cd00116    99 gVLESLLRSSSLQELKLNNNGLGDRGLRL-----------LAKGLKDLPP------ALEKLVLGRNRLE-----GASCEA 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 245 LELlylrrnklrvlpEFPSCRQLKELYLAENQIEKLGAEHL----QHLQAILVLDLRSNKLRS-----VPEEMALLQSLE 315
Cdd:cd00116   157 LAK------------ALRANRDLKELNLANNGIGDAGIRALaeglKANCNLEVLDLNNNGLTDegasaLAETLASLKSLE 224

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 316 RLDLSNNDISSLPCS-------LGNLHLKFLALEGNplrtirrEIIAKGTQEVLKYLRSK 368
Cdd:cd00116   225 VLNLGDNNLTDAGAAalasallSPNISLLTLSLSCN-------DITDDGAKDLAEVLAEK 277
LRR_8 pfam13855
Leucine rich repeat;
265-324 1.40e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.67  E-value: 1.40e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2175849829 265 RQLKELYLAENQIEKLGAEHLQHLQAILVLDLRSNKLRSV-PEEMALLQSLERLDLSNNDI 324
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
83-175 1.80e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 54.32  E-value: 1.80e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829  83 DLTKLIISSNKLQSLSDDLRllPALTVLDIHDNQLTSLPSAIREldNLQKLNVSHNKLKMLPEEITSLknLKALHLQHNE 162
Cdd:PRK15370  326 GLKTLEAGENALTSLPASLP--PELQVLDVSKNQITVLPETLPP--TITTLDVSRNALTNLPENLPAA--LQIMQASRNN 399

                          90
                  ....*....|...
gi 2175849829 163 LTCIPEGFEHLSS 175
Cdd:PRK15370  400 LVRLPESLPHFRG 412
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
82-260 2.33e-07

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 54.01  E-value: 2.33e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829  82 TDLTKLIISSNKLQSLSddlRLLPALTVLDIHDNQLTSLPSAIREL-----------------DNLQKLNVSHNKLKMLP 144
Cdd:PRK15387  282 SGLCKLWIFGNQLTSLP---VLPPGLQELSVSDNQLASLPALPSELcklwaynnqltslptlpSGLQELSVSDNQLASLP 358

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 145 EEITSLKNLKALHLQHNELTCIPEGfehlssLEDLDLSSNRLATVPAdfallsnllrlnlssnqlknLPAEisrmkrLKH 224
Cdd:PRK15387  359 TLPSELYKLWAYNNRLTSLPALPSG------LKELIVSGNRLTSLPV--------------------LPSE------LKE 406

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 2175849829 225 LDCDANLLETVPPDVGSMESLELLylrRNKLRVLPE 260
Cdd:PRK15387  407 LMVSGNRLTSLPMLPSGLLSLSVY---RNQLTRLPE 439
LRR_8 pfam13855
Leucine rich repeat;
84-140 6.33e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.75  E-value: 6.33e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2175849829  84 LTKLIISSNKLQSLSDD-LRLLPALTVLDIHDNQLTSL-PSAIRELDNLQKLNVSHNKL 140
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 120-191 1.97e-06

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 50.97  E-value: 1.97e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2175849829 120 LPSAIRELDNLQKLNVSHNKLK-MLPEEITSLKNLKALHLQHNELT-CIPEGFEHLSSLEDLDLSSNRLA-TVPA 191
Cdd:PLN03150  434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLSgRVPA 508
LRR_8 pfam13855
Leucine rich repeat;
105-163 3.35e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.44  E-value: 3.35e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2175849829 105 PALTVLDIHDNQLTSL-PSAIRELDNLQKLNVSHNKLKML-PEEITSLKNLKALHLQHNEL 163
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 460-587 2.26e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.54  E-value: 2.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 460 KLSLVSHELCLLQKLaflDLRNNFLS-SLPEEMSSLT-KLQTINLSFNRFKvFPAVLYHISTLETILISNNQVGSVDPLK 537
Cdd:PLN00113   84 KISSAIFRLPYIQTI---NLSNNQLSgPIPDDIFTTSsSLRYLNLSNNNFT-GSIPRGSIPNLETLDLSNNMLSGEIPND 159

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2175849829 538 MKLMENLSTLDLQNNDLL-QIPPELGNCVQLRTLLLDGNPF--RVPRAAILMK 587
Cdd:PLN00113  160 IGSFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQLvgQIPRELGQMK 212
PLN03150 PLN03150
hypothetical protein; Provisional
 477-582 3.50e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 46.73  E-value: 3.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 477 LDLRNNFLSS-LPEEMSSLTKLQTINLSFNRFKvfpavlyhistletilisnnqvGSVdPLKMKLMENLSTLDLQNNDLL 555
Cdd:PLN03150  423 LGLDNQGLRGfIPNDISKLRHLQSINLSGNSIR----------------------GNI-PPSLGSITSLEVLDLSYNSFN 479

                          90       100       110
                  ....*....|....*....|....*....|
gi 2175849829 556 -QIPPELGNCVQLRTLLLDGNPF--RVPRA 582
Cdd:PLN03150  480 gSIPESLGQLTSLRILNLNGNSLsgRVPAA 509
LRR_8 pfam13855
Leucine rich repeat;
244-301 4.75e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.36  E-value: 4.75e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 244 SLELLYLRRNKLRVLPE--FPSCRQLKELYLAENQIEKLGAEHLQHLQAILVLDLRSNKL 301
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 471-577 5.95e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.78  E-value: 5.95e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 471 LQKLAFLDLRNNFLSSLpEEMSSLTKLQTINLSFNRFKV---------------------------F-PAVLYHIS-TLE 521
Cdd:cd21340    45 LTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLGGNRISVveglenltnleelhienqrlppgekltFdPRSLAALSnSLR 123

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2175849829 522 TILISNNQVGSVDPLKmkLMENLSTLDLQNN---DLLQIPPELGNCVQLRTLLLDGNPF 577
Cdd:cd21340   124 VLNISGNNIDSLEPLA--PLRNLEQLDASNNqisDLEELLDLLSSWPSLRELDLTGNPV 180
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
82-187 1.24e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 45.15  E-value: 1.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829  82 TDLTKLIISSNKLQSLSddlRLLPALTVLDIHDNQLTSLPSAIRELdnlQKLNVSHNKLKMLPEEITSLKNLKalhLQHN 161
Cdd:PRK15387  362 SELYKLWAYNNRLTSLP---ALPSGLKELIVSGNRLTSLPVLPSEL---KELMVSGNRLTSLPMLPSGLLSLS---VYRN 432

                          90       100
                  ....*....|....*....|....*.
gi 2175849829 162 ELTCIPEGFEHLSSLEDLDLSSNRLA 187
Cdd:PRK15387  433 QLTRLPESLIHLSSETTVNLEGNPLS 458
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
212-505 1.88e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 44.38  E-value: 1.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 212 LPAEISRMkrlkhLDCDANL--LETVPPDVGSMEslellyLRRNKLRVLPEFPScrQLKELYLAENQIEklgaeHLQHLQ 289
Cdd:PRK15387  220 LPAHITTL-----VIPDNNLtsLPALPPELRTLE------VSGNQLTSLPVLPP--GLLELSIFSNPLT-----HLPALP 281

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 290 AILV-LDLRSNKLRSVPeemALLQSLERLDLSNNDISSLPcSLGNLHLKFLALEgNPLRTIrrEIIAKGTQEVlkylrsK 368
Cdd:PRK15387  282 SGLCkLWIFGNQLTSLP---VLPPGLQELSVSDNQLASLP-ALPSELCKLWAYN-NQLTSL--PTLPSGLQEL------S 348

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 369 IKDdrtNQNDSVPetamTLPSEarvnihaivTLKLLDYSDKQATL--IPDDIfdatKNTVVtsinfSKNQLCEIPQRIAE 446
Cdd:PRK15387  349 VSD---NQLASLP----TLPSE---------LYKLWAYNNRLTSLpaLPSGL----KELIV-----SGNRLTSLPVLPSE 403

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2175849829 447 LKEMVLdvnlSFNKLSLVShelCLLQKLAFLDLRNNFLSSLPEEMSSLTKLQTINLSFN 505
Cdd:PRK15387  404 LKELMV----SGNRLTSLP---MLPSGLLSLSVYRNQLTRLPESLIHLSSETTVNLEGN 455
PLN03150 PLN03150
hypothetical protein; Provisional
 260-336 2.17e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 44.42  E-value: 2.17e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2175849829 260 EFPSCRQLKELYLAENQIEKLGAEHLQHLQAILVLDLRSNKLR-SVPEEMALLQSLERLDLSNNDISS-LPCSLGNLHL 336
Cdd:PLN03150  437 DISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLSGrVPAALGGRLL 515
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 266-437 5.07e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 42.85  E-value: 5.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 266 QLKELYLAENQIEKLGA----EHLQHLQAILVLDLRSNKLrSVPEEMALLQSL------ERLDLSNNDIS-----SLPCS 330
Cdd:COG5238   209 TVTTLWLKRNPIGDEGAeilaEALKGNKSLTTLDLSNNQI-GDEGVIALAEALknnttvETLYLSGNQIGaegaiALAKA 287

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 331 L-GNLHLKFLALEGNPLRTIRREIIAKGTQEvlkylRSKIKDDRTNQNDSVPETAMTLpSEARVNIHAIVTLKLLD--YS 407
Cdd:COG5238   288 LqGNTTLTSLDLSVNRIGDEGAIALAEGLQG-----NKTLHTLNLAYNGIGAQGAIAL-AKALQENTTLHSLDLSDnqIG 361

                         170       180       190
                  ....*....|....*....|....*....|
gi 2175849829 408 DKQATLIPDDIfdaTKNTVVTSINFSKNQL 437
Cdd:COG5238   362 DEGAIALAKYL---EGNTTLRELNLGKNNI 388
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 69-186 2.17e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.42  E-value: 2.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829  69 NLSFSSTERWWE----QTDLTKLIISSNKL-----QSLSDDLRLLPALTVLDIHDNQLTS-----LPSAIRELDNLQKLN 134
Cdd:cd00116   148 RLEGASCEALAKalraNRDLKELNLANNGIgdagiRALAEGLKANCNLEVLDLNNNGLTDegasaLAETLASLKSLEVLN 227

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2175849829 135 VSHNKL------KMLPEEITSLKNLKALHLQHNELTCipEGFEHLS-------SLEDLDLSSNRL 186
Cdd:cd00116   228 LGDNNLtdagaaALASALLSPNISLLTLSLSCNDITD--DGAKDLAevlaekeSLLELDLRGNKF 290
LRR_8 pfam13855
Leucine rich repeat;
221-277 4.66e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.58  E-value: 4.66e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 221 RLKHLDCDANLLETVPPDV-GSMESLELLYLRRNKLRVLPE--FPSCRQLKELYLAENQI 277
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
518-577 4.75e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.58  E-value: 4.75e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2175849829 518 STLETILISNNQVGSVDPLKMKLMENLSTLDLQNNDLLQIPPE-LGNCVQLRTLLLDGNPF 577
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
152-192 5.29e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.58  E-value: 5.29e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2175849829 152 NLKALHLQHNELTCIPEG-FEHLSSLEDLDLSSNRLATVPAD 192
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLTTLSPG 43
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 248-556 6.12e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 39.26  E-value: 6.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 248 LYLRRNKL---RVLPEFPSCRQLKELYLAENQIEKLG----AEHLQHLQAILVLDLRSNKLRSVPEEMALLQS------- 313
Cdd:cd00116     3 LSLKGELLkteRATELLPKLLCLQVLRLEGNTLGEEAakalASALRPQPSLKELCLSLNETGRIPRGLQSLLQgltkgcg 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 314 LERLDLSNNDISSLPC----------SLGNLHLKFLALEGNPLRtirreIIAKGTQEVLKYLRSKIKDDRTNQNDSVPET 383
Cdd:cd00116    83 LQELDLSDNALGPDGCgvlesllrssSLQELKLNNNGLGDRGLR-----LLAKGLKDLPPALEKLVLGRNRLEGASCEAL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 384 AMTLPsearvnihAIVTLKLLdysdkqatlipddifdatkntvvtsiNFSKNQLceIPQRIAELKemvldvnlsfnklsl 463
Cdd:cd00116   158 AKALR--------ANRDLKEL--------------------------NLANNGI--GDAGIRALA--------------- 186

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849829 464 vsHELCLLQKLAFLDLRNNFL-----SSLPEEMSSLTKLQTINLSFNRF------KVFPAVLYHISTLETILISNNQVGS 532
Cdd:cd00116   187 --EGLKANCNLEVLDLNNNGLtdegaSALAETLASLKSLEVLNLGDNNLtdagaaALASALLSPNISLLTLSLSCNDITD 264

                         330       340
                  ....*....|....*....|....*...
gi 2175849829 533 VDPLK----MKLMENLSTLDLQNNDLLQ 556
Cdd:cd00116   265 DGAKDlaevLAEKESLLELDLRGNKFGE 292
LRR_8 pfam13855
Leucine rich repeat;
477-530 7.04e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.19  E-value: 7.04e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2175849829 477 LDLRNNFLSSLPEEM-SSLTKLQTINLSFNRFKVF-PAVLYHISTLETILISNNQV 530
Cdd:pfam13855   6 LDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
293-346 7.47e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.19  E-value: 7.47e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2175849829 293 VLDLRSNKLRSVPEEMAL-LQSLERLDLSNNDISSL-PCSLGNLH-LKFLALEGNPL 346
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLsPGAFSGLPsLRYLDLSGNRL 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH