NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|84370244|ref|NP_001033689|]
View 

mu-type opioid receptor isoform 1C1 [Rattus norvegicus]

Protein Classification

G protein-coupled receptor family protein; olfactory receptor subfamily 2A protein( domain architecture ID 11606795)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters| olfactory receptor (OR) subfamily 2A protein, such as human olfactory receptor 2A2 and related proteins in other mammals and sauropsids; ORs play a central role in olfaction, the sense of smell, and belong to the class A rhodopsin-like family of seven-transmembrane G protein-coupled receptors (7TM GPCRs)

Graphical summary

 Zoom to residue level

show extra options Â»

Show site features     Horizontal zoom: Ã—

List of domain hits

Name Accession Description Interval E-value
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
69-347 0e+00

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


:

Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 543.82  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDY 148
Cdd:cd15090   1 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGNILCKIVISIDY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 149 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYW 228
Cdd:cd15090  81 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPSWYW 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 229 ENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITI 308
Cdd:cd15090 161 ENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTI 240
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 84370244 309 PETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15090 241 PETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 279
 
Name Accession Description Interval E-value
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
69-347 0e+00

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 543.82  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDY 148
Cdd:cd15090   1 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGNILCKIVISIDY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 149 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYW 228
Cdd:cd15090  81 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPSWYW 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 229 ENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITI 308
Cdd:cd15090 161 ENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTI 240
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 84370244 309 PETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15090 241 PETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 279
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
85-336 9.71e-72

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 226.79  E-value: 9.71e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244    85 GNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLM-GTWPFGTILCKIVISIDYYNMFTSIFTLCTMS 162
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLfSLLTLPFWLVYYLNhGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244   163 VDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYR--QGSIDCTLTFSHPTWYWEnLLKICVFIFA 240
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVpeGNVTVCFIDFPEDLSKPV-SYTLLISVLG 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244   241 FIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPE-TTFQTVSWH 319
Cdd:pfam00001 160 FLLPLLVILVCYTLIIRTLRKSASKQKSSERTQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCElSRLLDKALS 239
                         250
                  ....*....|....*..
gi 84370244   320 FCIALGYTNSCLNPVLY 336
Cdd:pfam00001 240 VTLWLAYVNSCLNPIIY 256
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
67-349 1.56e-43

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 155.71  E-value: 1.56e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244   67 TAITIMALYSIVCVVGLFGNFLVMYVIvRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISI 146
Cdd:PHA03087  39 NSTILIVVYSTIFFFGLVGNIIVIYVL-TKTKIKTPMDIYLLNLAVSDLLFVMTLPFQIYYYILFQWSFGEFACKIVSGL 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  147 DYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTW 226
Cdd:PHA03087 118 YYIGFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTPILFVYTTKKDHETLICCMFYNNKTM 197
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  227 YWENLLKICVFIFAFIMPVLIITVCYGLMILRLKsvrmlsGSKEKDRNLRRItRMVLVVVAVFIVCWTPIHIYVIIKALI 306
Cdd:PHA03087 198 NWKLFINFEINIIGMLIPLTILLYCYSKILITLK------GINKSKKNKKAI-KLVLIIVILFVIFWLPFNVSVFVYSLH 270
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 84370244  307 TIPETT------FQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFRE 349
Cdd:PHA03087 271 ILHFKSgckavkYIQYALHVTEIISLSHCCINPLIYAFVSEFFNKHKKK 319
 
Name Accession Description Interval E-value
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
69-347 0e+00

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 543.82  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDY 148
Cdd:cd15090   1 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGNILCKIVISIDY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 149 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYW 228
Cdd:cd15090  81 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPSWYW 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 229 ENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITI 308
Cdd:cd15090 161 ENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTI 240
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 84370244 309 PETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15090 241 PETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 279
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
69-347 1.05e-157

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 447.47  E-value: 1.05e-157
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDY 148
Cdd:cd15089   1 IAITALYSVVCVVGLLGNVLVMYGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 149 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKY-RQGSIDCTLTFSHPTWY 227
Cdd:cd15089  81 YNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLSSGVGVPIMVMAVTKTpRDGAVVCMLQFPSPSWY 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 228 WENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALIT 307
Cdd:cd15089 161 WDTVTKICVFIFAFVVPILVITVCYGLMILRLRSVRLLSGSKEKDRNLRRITRMVLVVVAAFIICWTPIHIFVIVWTLVD 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 84370244 308 IPETTFQTV-SWHFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15089 241 IDRRNPLVVaALHLCIALGYANSSLNPVLYAFLDENFKRCF 281
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
69-347 1.39e-151

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 431.72  E-value: 1.39e-151
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDY 148
Cdd:cd14970   1 IVIPAVYSVVCVVGLTGNSLVIYVILRYSKMKTVTNIYILNLAVADELFLLGLPFLATSYLLGYWPFGEVMCKIVLSVDA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 149 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATT-KYRQGSIDCTLTFSHPTWY 227
Cdd:cd14970  81 YNMFTSIFCLTVMSVDRYLAVVHPVKSLRFRTPRKAKLVSLCVWALSLVLGLPVIIFARTlQEEGGTISCNLQWPDPPDY 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 228 WENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLS--GSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKAL 305
Cdd:cd14970 161 WGRVFTIYTFVLGFAVPLLVITVCYSLIIRRLRSSRNLStsGAREKRRARRKVTRLVLVVVAVFVVCWLPFHVFQIVRLL 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 84370244 306 ITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd14970 241 IDPPETLTVVGVFLFCIALSYANSCLNPILYAFLDENFRKSF 282
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
69-347 1.49e-146

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 418.97  E-value: 1.49e-146
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDY 148
Cdd:cd15091   1 VIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 149 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQ--GSIDCTLTF-SHPT 225
Cdd:cd15091  81 YNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREdvDSTECSLQFpDDDY 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 226 WYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKAL 305
Cdd:cd15091 161 SWWDTFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEAL 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 84370244 306 ITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15091 241 GSVSHSTAAVSSYYFCIALGYTNSSLNPILYAFLDENFKRCF 282
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
69-347 7.93e-139

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 399.24  E-value: 7.93e-139
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDY 148
Cdd:cd15092   1 VTIVVVYLIVCVVGLVGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDIFLGFWPFGNALCKTVIAIDY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 149 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYW 228
Cdd:cd15092  81 YNMFTSTFTLTAMSVDRYVAICHPIKALDVRTPHKAKVVNVCIWALASVVGVPVMVMGSAQVEDEEIECLVEIPTPQDYW 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 229 ENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITI 308
Cdd:cd15092 161 DPVFGICVFLFSFIIPVLIISVCYSLMIRRLRGVRLLSGSKEKDRNLRRITRLVLVVVAVFVGCWTPIQIFVLAQGLGVQ 240
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 84370244 309 PETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15092 241 PSSETAVAILRFCTALGYVNSSLNPVLYAFLDENFKACF 279
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
69-347 3.26e-90

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 275.49  E-value: 3.26e-90
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDY 148
Cdd:cd15093   1 VLIPCIYAVVCLVGLCGNSLVIYVVLRYAKMKTVTNIYILNLAIADELFMLGLPFLAASNALRHWPFGSVLCRLVLSVDG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 149 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQ-GSIDCTLTFSHPTWY 227
Cdd:cd15093  81 INMFTSIFCLTVMSVDRYLAVVHPIKSARWRRPRVAKVVNLAVWVASLLVILPVVVFAGTRENQdGSSACNMQWPEPAAA 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 228 WENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALIT 307
Cdd:cd15093 161 WSAGFIIYTFVLGFLLPLLIICLCYLLIVIKVKSAGLRAGWQQRKRSERKVTRMVVMVVVVFVICWLPFYVLQLVNVFVQ 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 84370244 308 IPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15093 241 LPETPALVGVYHFVVILSYANSCANPILYGFLSDNFKKSF 280
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
69-347 7.52e-81

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 251.37  E-value: 7.52e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDY 148
Cdd:cd15970   1 ILISFIYSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELLMLSVPFLVTSTLLRHWPFGSLLCRLVLSVDA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 149 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLP-VMFMATTKYRQGSIDCTLTFSHPTWY 227
Cdd:cd15970  81 INMFTSIYCLTVLSIDRYIAVVHPIKAARYRRPTVAKMVNLGVWVFSILVILPiIIFSNTAPNSDGSVACNMQMPEPSQR 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 228 WENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALIT 307
Cdd:cd15970 161 WLAVFVVYTFLMGFLLPVIAICLCYILIIVKMRVVALKAGWQQRKRSERKITLMVMMVVTVFVICWMPFYVVQLVSVFVG 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 84370244 308 IPETTFQTVSwhfcIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15970 241 QHDATVSQLS----VILGYANSCANPILYGFLSDNFKRSF 276
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
69-347 7.01e-79

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 245.92  E-value: 7.01e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDY 148
Cdd:cd15973   1 VVIQFIYALVCLVGLIGNSMVIFVILRYAKMKTATNIYILNLAIADELFMLSVPFLAASAALQHWPFGSAMCRTVLSVDG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 149 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQG-SIDCTLTFSHPTwy 227
Cdd:cd15973  81 INMFTSVFCLTVLSVDRYIAVVHPLRAARYRRPTVAKMINICVWILSLLVISPIIIFADTATRKGqAVACNLIWPHPA-- 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 228 WENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALIT 307
Cdd:cd15973 159 WSAAFVIYTFLLGFLLPVLAIGLCYILIIGKMRAVALKAGWQQRRKSEKKITRMVLMVVTVFVICWMPFYVVQLLNLFLP 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 84370244 308 IPETTFQtvswHFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15973 239 RLDATVN----HASLILSYANSCANPILYGFLSDNFRRSF 274
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
71-347 1.49e-75

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 237.82  E-value: 1.49e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  71 IMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYN 150
Cdd:cd15971   3 LTFIYFVVCIIGLCGNTLVIYVILRYAKMKTVTNIYILNLAIADELFMLGLPFLAIQVALVHWPFGKAICRVVMTVDGIN 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 151 MFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWEN 230
Cdd:cd15971  83 QFTSIFCLTVMSIDRYLAVVHPIKSAKWRKPRTAKMINMAVWGVSLLVILPIMIYAGVQTKHGRSSCTIIWPGESSAWYT 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 231 LLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPE 310
Cdd:cd15971 163 GFIIYTFILGFFVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFVFCWLPFYIFNVSSVSVSISP 242
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 84370244 311 TTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15971 243 TPGLKGMFDFVVVLSYANSCANPILYAFLSDNFKKSF 279
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
69-347 3.84e-73

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 231.55  E-value: 3.84e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDY 148
Cdd:cd15087   1 VALPVIYSVICAVGLTGNTAVIYVILRAPKMKTVTNVFILNLAIADDLFTLVLPINIAEHLLQQWPFGELLCKLILSIDH 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 149 YNMFTSIFTLCTMSVDRYIAVCHPV--KALDFRTPRNAKIVNVCNWILSSAIGLP-VMFMATTKYRQGSIDCTLTFSHPT 225
Cdd:cd15087  81 YNIFSSIYFLTVMSVDRYLVVLATVrsRRMPYRTYRAAKIVSLCVWLLVTIIVLPfTVFAGVYSNELGRKSCVLSFPSPE 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 226 WYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKAL 305
Cdd:cd15087 161 SLWFKASRIYTLVLGFAIPVSTICILYTMMLYKLRNMRLNSNAKALDKAKKKVTLMVLVVLAVCLFCWTPFHLSTVVALT 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 84370244 306 ITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15087 241 TDLPQTPLVIGISYFITSLSYANSCLNPFLYAFLDDSFRKSF 282
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
85-336 9.71e-72

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 226.79  E-value: 9.71e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244    85 GNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLM-GTWPFGTILCKIVISIDYYNMFTSIFTLCTMS 162
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLfSLLTLPFWLVYYLNhGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244   163 VDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYR--QGSIDCTLTFSHPTWYWEnLLKICVFIFA 240
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVpeGNVTVCFIDFPEDLSKPV-SYTLLISVLG 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244   241 FIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPE-TTFQTVSWH 319
Cdd:pfam00001 160 FLLPLLVILVCYTLIIRTLRKSASKQKSSERTQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCElSRLLDKALS 239
                         250
                  ....*....|....*..
gi 84370244   320 FCIALGYTNSCLNPVLY 336
Cdd:pfam00001 240 VTLWLAYVNSCLNPIIY 256
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
74-347 2.48e-71

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 226.97  E-value: 2.48e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  74 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFT 153
Cdd:cd15094   6 LYGLICIVGLVGNGLVIYVVLRYAKMKTVTNLYILNLAVADECFLIGLPFLIVTMILKYWPFGAAMCKIYMVLTSINQFT 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 154 SIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHP--------- 224
Cdd:cd15094  86 SSFTLTVMSADRYLAVCHPIRSMRYRTPFIAKVVCATTWSISFLVMLPIILYASTVPDSGRYSCTIVWPDSsavngqkaf 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 225 TWYwenllkicVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIikA 304
Cdd:cd15094 166 TLY--------TFLLGFAIPLLLISVFYTLVILRLRTVGPKNKSKEKRRSHRKVTRLVLTVISVYIICWLPYWAFQV--H 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 84370244 305 LITIPETTfQTVSWHFCI-----ALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15094 236 LIFLPPGT-DMPKWEILMfllltVLSYANSMVNPLLYAFLSENFRKSF 282
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
71-347 2.43e-70

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 224.30  E-value: 2.43e-70
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  71 IMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYN 150
Cdd:cd15974   3 IPVIYLLVCAIGLSGNTLVIYVVLRYAKMKTVTNIYILNLAVADELFMLGLPFLATQNAISYWPFGSFLCRLVMTVDGVN 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 151 MFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSidCTLTFSHPTWYWEN 230
Cdd:cd15974  83 QFTSIFCLTVMSIDRYLAVVHPIKSTKWRRPRVAKLINATVWTLSFLVVLPVIIFSDVQPDLNT--CNISWPEPVSVWST 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 231 LLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPE 310
Cdd:cd15974 161 AFIIYTAVLGFFGPLLVICLCYLLIVIKVKSSGLRVGSTKRRKSERKVTRMVVIIVVVFVFCWLPFYMLNIVNLIVILPE 240
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 84370244 311 TTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15974 241 EPAFVGVYFFVVVLSYANSCANPILYGFLSDNFKQSF 277
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
69-345 2.43e-67

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 216.55  E-value: 2.43e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLM-GTWPFGTILCKIVISID 147
Cdd:cd15088   1 VIMPSVFGCICVVGLVGNGIVLYVLVRCSKLRTAPDIFIFNLAVADLLFMLGMPFLIHQFAIdGQWYFGEVMCKIITALD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 148 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPV-MFMATTKYRQGSIDCTLTFSHPT- 225
Cdd:cd15088  81 ANNQFTSTYILTAMSVDRYLAVVHPIRSTKYRTRFVAKLVNVGLWAASFLSILPVwVYSSLIYFPDGTTFCYVSLPSPDd 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 226 WYWenlLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKAL 305
Cdd:cd15088 161 LYW---FTIYHFILGFAVPLVVITVCYILILHRLARGVAPGNQSHGSSRTKRVTKMVILIVVVFIVCWLPFHVVQLVNLA 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 84370244 306 ITIPETTFQtVSWHFCIALGYTNSCLNPVLYAFLDENFKR 345
Cdd:cd15088 238 MNRPTLAFE-VAYFLSICLGYANSCLNPFVYILVSENFRK 276
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
69-347 9.18e-67

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 215.05  E-value: 9.18e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDY 148
Cdd:cd15972   1 VLIPLVYLVVCVVGLGGNTLVIYVVLRYSASESVTNIYILNLALADELFMLGLPFLAAQNALSYWPFGSFMCRLVMTVDA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 149 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSidCTLTFSHPTWYW 228
Cdd:cd15972  81 INQFTSIFCLTVMSVDRYLAVVHPIRSSKWRKPPVAKTVNATVWALSFLVVLPVVIFSGVPGGMGT--CHIAWPEPAQVW 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 229 ENLLKICVFIFAFIMPVLIITVCYGLMILRLKSV--RMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALI 306
Cdd:cd15972 159 RAGFIIYTATLGFFCPLLVICLCYLLIVVKVRSSgrRVRATSTKRRGSERKVTRMVVIVVAAFVLCWLPFYALNIVNLVC 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 84370244 307 TIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15972 239 PLPEEPSLFGLYFFVVVLSYANSCANPIIYGFLSDNFKQGF 279
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
71-339 1.82e-65

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 211.38  E-value: 1.82e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  71 IMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISIDYY 149
Cdd:cd00637   1 LAVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLvGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 150 NMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCtlTFSHPTWYWE 229
Cdd:cd00637  81 SLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCC--CLCWPDLTLS 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 230 NLLKICVFIFAFIMPVLIITVCYGLMILRLK-------SVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVII 302
Cdd:cd00637 159 KAYTIFLFVLLFLLPLLVIIVCYVRIFRKLRrhrrrirSSSSNSSRRRRRRRERKVTKTLLIVVVVFLLCWLPYFILLLL 238
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 84370244 303 KALITIPETTFQTVsWHFCIALGYTNSCLNPVLYAFL 339
Cdd:cd00637 239 DVFGPDPSPLPRIL-YFLALLLAYLNSAINPIIYAFF 274
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
69-347 1.24e-63

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 207.15  E-value: 1.24e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCKIVISID 147
Cdd:cd15096   1 IVVPVIFGLIFIVGLIGNSLVILVVLSNQQMRSTTNILILNLAVADlLFVVFCVPFTATDYVLPTWPFGDVWCKIVQYLV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 148 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYrQGSIDC---TLTFSHP 224
Cdd:cd15096  81 YVTAYASVYTLVLMSLDRYLAVVHPITSMSIRTERNTLIAIVGIWIVILVANIPVLFLHGVVS-YGFSSEaysYCTFLTE 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 225 TWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSG--SKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVII 302
Cdd:cd15096 160 VGTAAQTFFTSFFLFSYLIPLTLICVLYMLMLRRLRRQKSPGGrrSAESQRGKRRVTRLVVVVVVVFAICWLPIHIILLL 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 84370244 303 KALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15096 240 KYYGVLPETVLYVVIQILSNCLAYGNSCVNPILYAFLSQNFRKAF 284
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
69-347 1.33e-61

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 202.06  E-value: 1.33e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST-LPFQSVNYLMGTWPFGTILCKIVISID 147
Cdd:cd14993   1 IVLIVLYVVVFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFcMPLTLLENVYRPWVFGEVLCKAVPYLQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 148 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTF-----S 222
Cdd:cd14993  81 GVSVSASVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAIIIMLPLLVVYELEEIISSEPGTITIyicteD 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 223 HPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSV-------RMLSGSKEK-DRNLRRITRMVLVVVAVFIVCWT 294
Cdd:cd14993 161 WPSPELRKAYNVALFVVLYVLPLLIISVAYSLIGRRLWRRkppgdrgSANSTSSRRiLRSKKKVARMLIVVVVLFALSWL 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 84370244 295 PIHIYVIIKAL-ITIPETTFQTVS-WHFCIA-LGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd14993 241 PYYVLSILLDFgPLSSEESDENFLlILPFAQlLGYSNSAINPIIYCFMSKKFRRGF 296
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
73-347 3.92e-61

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 200.39  E-value: 3.92e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  73 ALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNM 151
Cdd:cd14971   5 LFFALIFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADlTFLLFCVPFTATIYPLPGWVFGDFMCKFVHYFQQVSM 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 152 FTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSidcTLTFSHPTW---YW 228
Cdd:cd14971  85 HASIFTLVAMSLDRFLAVVYPLRSLHIRTPRNALAASGCIWVVSLAVAAPVLALHRLRNYTPG---NRTVCSEAWpsrAH 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 229 ENLLKICVFIFAFIMPVLIITVCYGLMILRL-KSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALIT 307
Cdd:cd14971 162 RRAFALCTFLFGYLLPLLLICVCYAAMLRHLwRVAVRPVLSEGSRRAKRKVTRLVLVVVVLFAACWGPIHAILLLVALGP 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 84370244 308 IPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd14971 242 FPLTYATYALRIWAHCLAYSNSAVNPVLYAFLSEHFRKAF 281
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
73-347 4.34e-58

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 192.88  E-value: 4.34e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  73 ALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCKIVisidYYNM 151
Cdd:cd15095   5 LIFAIIFLVGLAGNSLVIYVVSRHREMRTVTNYYIVNLAVTDlAFLVCCVPFTAALYATPSWVFGDFMCKFV----NYMM 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 152 FTSI----FTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKyrQGSIDCTLTFSHPTW- 226
Cdd:cd15095  81 QVTVqatcLTLTALSVDRYYAIVHPIRSLRFRTPRVAVVVSACIWIVSFLLSIPVAIYYRLE--EGYWYGPQTYCREVWp 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 227 --YWENLLKICVFIFAFIMPVLIITVCYGLMILRL---KSVRMLSGSKEKDRNL---RRITRMVLVVVAVFIVCWTPIHI 298
Cdd:cd15095 159 skAFQKAYMIYTVLLTYVIPLAIIAVCYGLILRRLwrrSVDGNNQSEQLSERALrqkRKVTRMVIVVVVLFAICWLPNHV 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 84370244 299 YVIIKAL-ITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15095 239 LNLWQRFdPNFPETYATYALKIAALCLSYANSAVNPFVYAFMGENFRKYF 288
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
70-347 1.01e-56

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 188.16  E-value: 1.01e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  70 TIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISIDY 148
Cdd:cd14967   1 LLAVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLvALLVMPFSAVYTLLGYWPFGPVLCRFWIALDV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 149 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYW 228
Cdd:cd14967  81 LCCTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISLPPLVGWRDETQPSVVDCECEFTPNKIYV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 229 enllkICVFIFAFIMPVLIITVCYGLMILRLKsvrmlsgsKEkdrnlRRITRMVLVVVAVFIVCWTPIHIYVIIKALI-- 306
Cdd:cd14967 161 -----LVSSVISFFIPLLIMIVLYARIFRVAR--------RE-----LKAAKTLAIIVGAFLLCWLPFFIIYLVSAFCpp 222
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 84370244 307 -TIPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd14967 223 dCVPPILYAVFFW-----LGYLNSALNPIIYALFNRDFRRAF 259
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
73-345 1.13e-56

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 188.58  E-value: 1.13e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  73 ALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGtWPFGTILCKIVISIDYYNMF 152
Cdd:cd14984   5 VLYSLVFLLGLVGNSLVLLVLLYYRKLRSMTDVYLLNLALADLLFVLTLPFWAVYAADG-WVFGSFLCKLVSALYTINFY 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 153 TSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWY-WENL 231
Cdd:cd14984  84 SGILFLACISIDRYLAIVHAVSALRARTLLHGKLTCLGVWALALLLSLPEFIFSQVSEENGSSICSYDYPEDTATtWKTL 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 232 LKICVFIFAFIMPVLIITVCYGLMILRLKSvrmlSGSKEKDRNLRRItrmvLVVVAVFIVCWTPIHIYVIIKAL----IT 307
Cdd:cd14984 164 LRLLQNILGFLLPLLVMLFCYSRIIRTLLR----ARNHKKHRALRVI----FAVVVVFFLCWLPYNIVLLLDTLqllgII 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 84370244 308 IPETTFQT---VSWHFCIALGYTNSCLNPVLYAFLDENFKR 345
Cdd:cd14984 236 SRSCELSKsldYALQVTESLAFSHCCLNPVLYAFVGVKFRK 276
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
69-347 1.23e-56

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 188.78  E-value: 1.23e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMK--TATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCKIVIS 145
Cdd:cd15098   1 VIVPVVFGLIFCLGVLGNSLVITVLARVKPGKrrSTTNVFILNLSIADlFFLLFCVPFQATIYSLPEWVFGAFMCKFVHY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 146 IDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDctLTFSHPT 225
Cdd:cd15098  81 FFTVSMLVSIFTLVAMSVDRYIAVVHSRTSSSLRTRRNALLGVLVIWVLSLAMASPVAVHQDLVHHWTASN--QTFCWEN 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 226 WY---WENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVrMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVII 302
Cdd:cd15098 159 WPekqQKPVYVVCTFVFGYLLPLLLITFCYAKVLNHLHKK-LKNMSKKSERSKKKTAQTVLVVVVVFGISWLPHHIIHLW 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 84370244 303 KALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15098 238 VEFGDFPLTQASFVLRITAHCLAYANSCVNPIIYAFLSENFRKAY 282
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
72-345 3.19e-56

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 187.47  E-value: 3.19e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  72 MALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGT-WPFGTILCKIVISIDYYN 150
Cdd:cd14982   4 PIVYSLIFILGLLGNILALWVFLRKMKKRSPTTIYMINLALADLLFVLTLPFRIYYYLNGGwWPFGDFLCRLTGLLFYIN 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 151 MFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWEN 230
Cdd:cd14982  84 MYGSILFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWILVLVASVPLLLLRSTIAKENNSTTCFEFLSEWLASAA 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 231 LLKICVFIFAFIMPVLIITVCYGLMIlrlKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIH---IYVIIKALIT 307
Cdd:cd14982 164 PIVLIALVVGFLIPLLIILVCYSLII---RALRRRSKQSQKSVRKRKALRMILIVLAVFLVCFLPYHvtrILYLLVRLSF 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 84370244 308 IPETTFQ--TVSWH-FCIALGYTNSCLNPVLYAFLDENFKR 345
Cdd:cd14982 241 IADCSARnsLYKAYrITLCLASLNSCLDPLIYYFLSKTFRK 281
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
69-347 7.54e-55

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 183.66  E-value: 7.54e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYViVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMG-TWPFGTILCKIVISID 147
Cdd:cd14974   1 IVSLVLYALIFLLGLPGNGLVIWV-AGFKMKRTVNTVWFLNLALADFLFCLFLPFLIVYIAMGhHWPFGSVLCKLNSFVI 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 148 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLT-FSHPTW 226
Cdd:cd14974  80 SLNMFASVFLLTAISLDRCLLVLHPVWAQNHRTVRLASVVCVGIWILALVLSVPYFVFRDTVTHHNGRSCNLTcVEDYDL 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 227 --YWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSkekdRNLRRITRMvlvvVAVFIVCWTPIHIYVIIKA 304
Cdd:cd14974 160 rrSRHKALTVIRFLCGFLLPLLIIAICYSVIAVKLRRKRLAKSS----KPLRVLLAV----VVAFFLCWLPYHVFALLEL 231
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 84370244 305 LITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd14974 232 VAAAGLPEVVLLGLPLATGLAYFNSCLNPILYVFMGQDFRKRL 274
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
71-345 2.55e-54

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 182.58  E-value: 2.55e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  71 IMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLM-GTWPFGTILCKIVISIDYY 149
Cdd:cd14985   3 IPALYIAIFLVGLLGNLFVVWVFLFPRGPKRVADIFIANLAAADLVFVLTLPLWATYTANqYDWPFGAFLCKVSSYVISV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 150 NMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWE 229
Cdd:cd14985  83 NMFASIFLLTCMSVDRYLAIVHPVASRRLRRRRQARVTCALIWVVACLLSLPTFLLRSLQAIENLNKTACIMLYPHEAWH 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 230 NLLKICVFIFAFIMPVLIITVCYGLMILRLKsvRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITI- 308
Cdd:cd14985 163 FGLSLELNILGFVLPLLIILTCYFHIARSLR--KRYERTGKNGRKRRKSLKIIFALVVAFLVCWLPFHFFKFLDFLAQLg 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 84370244 309 -----PETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKR 345
Cdd:cd14985 241 airpcFWELFLDLGLPIATCLAFTNSCLNPFIYVFVDRRFRQ 282
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
69-347 3.18e-52

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 177.41  E-value: 3.18e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATS-TLPFQSVNYLMGTWPFGTILCKIVISID 147
Cdd:cd15203   1 IILILLYGLIIVLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLvSLPFTLIYTLTKNWPFGSILCKLVPSLQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 148 YYNMFTSIFTLCTMSVDRYIAVCHPVKalDFRTPRNAKIVNVCNWILSSAIGLPV-MFMATTKYRQGSIDCTLTF---SH 223
Cdd:cd15203  81 GVSIFVSTLTLTAIAIDRYQLIVYPTR--PRMSKRHALLIIALIWILSLLLSLPLaIFQELSDVPIEILPYCGYFcteSW 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 224 PTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKS-VRMLSGSKEKD--------RNLRRITRMVLVVVAVFIVCWT 294
Cdd:cd15203 159 PSSSSRLIYTISVLVLQFVIPLLIISFCYFRISLKLRKrVKKKRGKRTLSsrrrrselRRKRRTNRLLIAMVVVFAVCWL 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 84370244 295 PIHIYVII---KALITIPETTFQTVSWhFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15203 239 PLNLFNLLrdfEPLPQIDGRHFYLIFL-ICHLIAMSSACVNPLLYGWLNDNFRKEF 293
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
73-347 1.90e-49

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 169.81  E-value: 1.90e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  73 ALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGT-WPFGTILCKIVISIDYYNM 151
Cdd:cd15168   5 IVYGVVFLVGLLLNSVVLYRFIFHLKPWNSSAIYMFNLAVSDLLYLLSLPFLIYYYANGDhWIFGDFMCKLVRFLFYFNL 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 152 FTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSH---PTWYW 228
Cdd:cd15168  85 YGSILFLTCISVHRYLGICHPLRSLGKLKKRHAVAISVAVWILVLLQLLPILFFATTGRKNNRTTCYDTTSPeelNDYVI 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 229 ENllkICVFIFAFIMPVLIITVCYGLMILRL-KSVRMLSGSKEKdrnlRRITRMVLVVVAVFIVCWTPIHI----YVIIK 303
Cdd:cd15168 165 YS---MVLTGLGFLLPLLIILACYGLIVRALiRKLGEGVTSALR----RKSIRLVIIVLALFAVCFLPFHVtrtiNLAAR 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 84370244 304 AL-ITIPETTFQTVSWHFCIA--LGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15168 238 LLsGTASCATLNGIYVAYKVTrpLASLNSCLNPLLYFLAGDKFRRRL 284
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
75-347 6.55e-48

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 165.14  E-value: 6.55e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  75 YSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST-LPFQSVNYLMGTWPFGTILCKIVISIDYYNMFT 153
Cdd:cd15001   6 YVITFVLGLIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFcVPLKTAEYFSPTWSLGAFLCKAVAYLQLLSFIC 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 154 SIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFmaTTKYRQGSIDCTLTFSH-----PTWYW 228
Cdd:cd15001  86 SVLTLTAISIERYYVILHPMKAKSFCTIGRARKVALLIWILSAILASPVLF--GQGLVRYESENGVTVYHcqkawPSTLY 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 229 ENLLKICVFIFAFIMPVLIITVCYGLmilrlksvrmlsgskekdRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITI 308
Cdd:cd15001 164 SRLYVVYLAIVIFFIPLIVMTFAYAR------------------DTRKQVIKMLISVVVLFAVCWGPLLIDNLLVSFDVI 225
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 84370244 309 PETTFQTV-SWHFCI-ALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15001 226 STLHTQALkYMRIAFhLLSYANSCINPIIYAFMSKNFRSSF 266
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
69-347 1.13e-46

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 162.67  E-value: 1.13e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTA--TNIYIFNLALADALATSTLPFQSVNY-LMGTWPFGTILCKIVIS 145
Cdd:cd14976   1 NLVSVVYMVVFTVGLLGNLLVLYLLKSNKKLRQQseSNKFVFNLALTDLIFVLTLPFWAVEYaLDFVWPFGTAMCKVVRY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 146 IDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSID-CTLTF--- 221
Cdd:cd14976  81 VTKLNMYSSIFFLTALSVTRYIAVARALKHGWIRKAFGAFATTIAIWAAAALAAIPEAIFSTDTWSSVNHTlCLLRFpkn 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 222 -SHPTWY-WENLLKICVFIFAFIMPVLIITVCYgLMILRLKSVRMLSGSkekdRNLRRITRMVLVVVAVFIVCWTPIHIY 299
Cdd:cd14976 161 sSVTRWYnWLGMYQLQKVVLGFFLPLGIITLSY-LLLLRFLQRKRGGSK----RRKSRVTKSVFIVVLSFFICWLPNQAL 235
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 84370244 300 VIIKALI---TIPET----TFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd14976 236 SLWSALIkfdDVPFSdaffAFQTYAFPVAICLAHSNSCLNPVLYCLVRREFRDAL 290
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
69-347 5.68e-46

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 160.67  E-value: 5.68e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMG-TWPFGTILCKIVISID 147
Cdd:cd15192   1 IMIPTVYSIIFVVGIFGNSLVVIVIYCYMKLKTVANIFLLNLALADLCFLITLPLWAAYTAMEyHWPFGNFLCKIASALV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 148 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTW- 226
Cdd:cd15192  81 SFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTLVVARVTCIVIWLLAGVASLPAIIHRDVFFIENTNITVCAFHYPSQn 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 227 -YWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNlrrITRMVLVVVAVFIVCWTPIHIYVIIKAL 305
Cdd:cd15192 161 sTLLVGLGLMKNLLGFLIPFLIILTCYTLIGKALKKAYEIQRNKPRNDE---IFKMIMAVVLFFFFCWIPHQIFTFLDVL 237
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 84370244 306 IT--------IPETTFQTVSWHFCIAlgYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15192 238 IQlkviqdchIADIVDTAMPFTICIA--YFNSCLNPILYGFVGKNFRKKF 285
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
69-347 2.93e-45

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 159.21  E-value: 2.93e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATS-TLPFQSVNYLMGTWPFGTILCKIVISID 147
Cdd:cd15202   1 VLLIVAYSFIIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLfNTPFTFVRAVNNTWIFGLFMCHFSNFAQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 148 YYNMFTSIFTLCTMSVDRYIAVCHPVKALdfRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTW- 226
Cdd:cd15202  81 YCSVHVSAYTLTAIAVDRYQAIMHPLKPR--ISKTKAKFIIAVIWTLALAFALPHAICSKLETFKYSEDIVRSLCLEDWp 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 227 ----YWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSK-----EKDRNLRRITRMVLVVVAVFIVCWTPIH 297
Cdd:cd15202 159 eradLFWKYYDLALFILQYFLPLLVISFAYARVGIKLWASNMPGDATteryfALRRKKKKVIKMLMVVVVLFALCWLPFN 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 84370244 298 IYVIIKALITIPETTFQTVSWhFCIA-LGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15202 239 IYVLLLSSKPDYLIKTINAVY-FAFHwLAMSSTCYNPFIYCWLNERFRIEF 288
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
69-347 5.52e-45

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 157.82  E-value: 5.52e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGtWPFGTILCKIVISIDY 148
Cdd:cd15178   1 LALCVIYVLVFLLSLPGNSLVVLVILYNRRSRSSTDVYLLHLAIADLLFALTLPFWAVSVVKG-WIFGTFMCKLVSLLQE 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 149 YNMFTSIFTLCTMSVDRYIAVchpVKALDFRTPRNAKIVNVCN--WILSSAIGLPVMFM--ATTKYRQGSIDCTLTFSHP 224
Cdd:cd15178  80 ANFYSGILLLACISVDRYLAI---VHATRALTQKRHLVKFVCAgvWLLSLLLSLPALLNrdAFKPPNSGRTVCYENLGNE 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 225 TWY-WENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLsgskEKDRNLRRItrmvLVVVAVFIVCWTPIHIYVIIK 303
Cdd:cd15178 157 SADkWRVVLRILRHTLGFLLPLVVMLFCYGFTIKTLLQTRSF----QKHRAMRVI----FAVVLAFLLCWLPYNVTVLID 228
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 84370244 304 ALI---TIPETTFQ----TVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15178 229 TLMrtkLITETCELrnhvDVALYVTQILGFLHSCINPVLYAFIGQKFRNNL 279
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
69-344 5.85e-45

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 157.62  E-value: 5.85e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIvrYTKMKTATN-IYIFNLALADALATSTLPFQSVNYLM-GTWPFGTILCKIVISI 146
Cdd:cd15115   1 ILSLVVLSLTFLLGVPGNGLVIWVA--GLKMKRTVNtIWFLNLAVADLLCCLSLPFSIAHLLLnGHWPYGRFLCKLLPSI 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 147 DYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFShptw 226
Cdd:cd15115  79 IVLNMFASVFTLTAISLDRFLLVIKPVWAQNHRSVLLACLLCGCIWILALLLCLPVFIYRTTVTDGNHTRCGYDFL---- 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 227 yweNLLKICVFIFAFIMPVLIITVCYGLMILrlksvRMLSGSKEKDRNlrRITRMVLVVVAVFIVCWTPIHIYVIIkALI 306
Cdd:cd15115 155 ---VAITITRAVFGFLLPLLIIAACYSFIAF-----RMQRGRFAKSQS--KTFRVIIAVVVAFFVCWAPYHIIGIL-SLY 223
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 84370244 307 TIPETTFQTVSW-HFCIALGYTNSCLNPVLYAFLDENFK 344
Cdd:cd15115 224 GDPPLSKVLMSWdHLSIALAYANSCLNPVLYVFMGKDFK 262
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
71-347 6.70e-45

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 157.91  E-value: 6.70e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  71 IMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSV-NYLMGTWPFGTILCKIVISIDY 148
Cdd:cd15392   3 IILMYSTIFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDILmAVFCVPFSFIaLLILQYWPFGEFMCPVVNYLQA 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 149 YNMFTSIFTLCTMSVDRYIAVCHPVKALdfRTPRNAKIVNVCNWILSSAIGLPVMFMATTkYRQGSIDCTLTF---SHPT 225
Cdd:cd15392  83 VSVFVSAFTLVAISIDRYVAIMWPLRPR--MTKRQALLLIAVIWIFALATALPIAITSRL-FEDSNASCGQYIcteSWPS 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 226 WYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMlSGSKEKDR------NLRRITRMVLVVVAVFIVCWTPIHIY 299
Cdd:cd15392 160 DTNRYIYSLVLMILQYFVPLAVLVFTYTRIGIVVWAKRT-PGEAENNRdqrmaeSKRKLVKMMITVVAIFALCWLPLNIL 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 84370244 300 VIIKALI-TIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15392 239 NLVGDHDeSIYSWPYIPYLWLAAHWLAMSHCCYNPFIYCWMNAKFRNGF 287
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
71-346 3.45e-44

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 156.85  E-value: 3.45e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  71 IMALYSIVCVVGLFGNFLVMYVIVRY-TKMKTATNIYIFNLALADALATSTLPFQSV-NYLMGTWPFGTILCKIVISIDY 148
Cdd:cd15190  13 IPVIYMLVFVLGLSGNGLVLWTVFRSkRKRRRSADTFIANLALADLTFVVTLPLWAVyTALGYHWPFGSFLCKLSSYLVF 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 149 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGS--IDCTLTFSHPT- 225
Cdd:cd15190  93 VNMYASVFCLTGLSFDRYLAIVRSLASAKLRSRTSGIVALGVIWLLAALLALPALILRTTSDLEGTnkVICDMDYSGVVs 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 226 ----WYWENLLKICVFIFAFIMPVLIITVCYGLmILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVI 301
Cdd:cd15190 173 neseWAWIAGLGLSSTVLGFLLPFLIMLTCYFF-IGRTVARHFSKLRRKEDKKKRRLLKIIITLVVTFALCWLPFHLVKT 251
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 84370244 302 IKALITIPETTFQTVSWHF-------CIALGYTNSCLNPVLYAFLDENF-KRC 346
Cdd:cd15190 252 LYALMYLGILPFSCGFDLFlmnahpyATCLAYVNSCLNPFLYAFFDPRFrQQC 304
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
69-345 6.55e-44

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 155.31  E-value: 6.55e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVryTKMKTATN-IYIFNLALADALATSTLPFQSVNYLMGT-WPFGTILCKIVISI 146
Cdd:cd15116   1 ILSMVIYSVVFVLGVLGNGLVIFITG--FKMKKTVNtVWFLNLAVADFLFTFFLPFSIAYTAMDFhWPFGRFMCKLNSFL 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 147 DYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQ--GSIDCTLTFSHP 224
Cdd:cd15116  79 LFLNMFTSVFLLTVISIDRCISVVFPVWSQNHRSVRLASLVSLAVWVVAFFLSSPSFIFRDTAPSQnnNKIICFNNFSLS 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 225 TWY---WENLLK--------ICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEkdrnlrriTRMVLVVVAVFIVCW 293
Cdd:cd15116 159 GDNsspEVNQLRnmrhqvmtITRFLLGFLIPFTIIICCYAAIVLKLKRNRLAKSSKP--------FKIIAAVIVTFFLCW 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 84370244 294 TPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKR 345
Cdd:cd15116 231 APYHILNLLEMEATRSPASVFKIGLPITSSLAFINSCLNPILYVFMGQDFKK 282
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
73-347 6.67e-44

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 155.36  E-value: 6.67e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  73 ALYSIVCVVGLFGNFLVMYVIVRYTKMK---TATNIYIFNLALADALATSTLPFQsVNYLMGT--WPFGTILCKIVISID 147
Cdd:cd15338   5 SVFGVICFLGIIGNSIVIYTIVKKSKFRcqqTVPDIFIFNLSIVDLLFLLGMPFL-IHQLLGNgvWHFGETMCTLITALD 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 148 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPV-MFMATTKYRQGSIDCTLTFSHPT- 225
Cdd:cd15338  84 TNSQITSTYILTVMTLDRYLATVHPIRSTKIRTPRVAVAVICLVWILSLLSITPVwMYAGLMPLPDGSVGCALLLPNPEt 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 226 -WYWENLLKicvFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKA 304
Cdd:cd15338 164 dTYWFTLYQ---FFLAFALPLVVICVVYFKILQNMASTVAPLPQRSLRVRTKKVTRMAVAICLAFFICWAPFYILQLAHL 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 84370244 305 LITIPETTFqTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15338 241 SIDRPSLAF-LYAYNVAISMGYANSCINPFLYIMLSETFKRQF 282
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
74-347 7.06e-44

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 155.26  E-value: 7.06e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  74 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMF 152
Cdd:cd15393   6 LYGIISLVAVVGNFLVIWVVAKNRRMRTVTNIFIANLAVADIIiGLFSIPFQFQAALLQRWVLPRFMCPFCPFVQVLSVN 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 153 TSIFTLCTMSVDRYIAVCHPVKAldFRTPRNAKIVNVCNWILSSAIGLPV-MFMATTKYRQGSIDCTLTFSHPTWY---W 228
Cdd:cd15393  86 VSVFTLTVIAVDRYRAVIHPLKA--RCSKKSAKIIILIIWILALLVALPVaLALRVEELTDKTNNGVKPFCLPVGPsddW 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 229 ENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVR-----MLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIK 303
Cdd:cd15393 164 WKIYNLYLVCVQYFVPLVIICYAYTRIAVKIWGTKapgnaQDVRDDEILKNKKKVIKMLIIVVALFALCWLPLQTYNLLN 243
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 84370244 304 ALI-TIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15393 244 EIKpEINKYKYINIIWFCSHWLAMSNSCYNPFIYGLYNEKFKREF 288
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
67-349 1.56e-43

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 155.71  E-value: 1.56e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244   67 TAITIMALYSIVCVVGLFGNFLVMYVIvRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISI 146
Cdd:PHA03087  39 NSTILIVVYSTIFFFGLVGNIIVIYVL-TKTKIKTPMDIYLLNLAVSDLLFVMTLPFQIYYYILFQWSFGEFACKIVSGL 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  147 DYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTW 226
Cdd:PHA03087 118 YYIGFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTPILFVYTTKKDHETLICCMFYNNKTM 197
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  227 YWENLLKICVFIFAFIMPVLIITVCYGLMILRLKsvrmlsGSKEKDRNLRRItRMVLVVVAVFIVCWTPIHIYVIIKALI 306
Cdd:PHA03087 198 NWKLFINFEINIIGMLIPLTILLYCYSKILITLK------GINKSKKNKKAI-KLVLIIVILFVIFWLPFNVSVFVYSLH 270
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 84370244  307 TIPETT------FQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFRE 349
Cdd:PHA03087 271 ILHFKSgckavkYIQYALHVTEIISLSHCCINPLIYAFVSEFFNKHKKK 319
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
73-345 3.48e-43

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 153.43  E-value: 3.48e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  73 ALYSIVCVVGLFGNFLVMYVIVRyTKMKTATNIYIFNLALADALATSTLPFQSVNYLMG-TWPFGTILCKIVISIDYYNM 151
Cdd:cd15339   5 SFIGILCSTGLVGNILVLFTIIR-SRKKTVPDIYVCNLAVADLVHIIVMPFLIHQWARGgEWVFGSPLCTIITSLDTCNQ 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 152 FTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATT-KYRQGSIDCTLTFSHPT-WYWE 229
Cdd:cd15339  84 FACSAIMTAMSLDRYIALVHPFRLTSLRTRSKTIRINLLVWAASFILVLPVWVYAKViKFRDGLESCAFNLTSPDdVLWY 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 230 NLLKIcvfIFAFIMPVLIITVCYGL-------MILRLKSVRMLSGSKEKDRnLRRITRMVLVVVAVFIVCWTPIHIYVII 302
Cdd:cd15339 164 TLYQT---ITTFFFPLPLILICYILilcytweMYRKNKKAGRYNTSIPRQR-VMRLTKMVLVLVGVFLVSAAPYHVIQLV 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 84370244 303 KALITIPETTFqTVSWHFCIALGYTNSCLNPVLYAFLDENFKR 345
Cdd:cd15339 240 NLSVSQPTLAF-YVSYYLSICLSYASSSINPFLYILLSGNFRK 281
7tmA_CXCR3 cd15180
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
71-345 6.36e-43

CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341335 [Multi-domain]  Cd Length: 280  Bit Score: 152.54  E-value: 6.36e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  71 IMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGtWPFGTILCKIVISIDYYN 150
Cdd:cd15180   3 LPVLYSLVFLLGLLGNGLVLAVLLQKRRNLSVTDTFILHLALADILLLVTLPFWAVQAVHG-WIFGTGLCKLAGAVFKIN 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 151 MFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVM-FMATTK-YRQGSIDCTLTFSHPTWYW 228
Cdd:cd15180  82 FYCGIFLLACISFDRYLSIVHAVQMYSRKKPMLVHLSCLIVWLFCLLLSIPDFiFLEATKdPRQNKTECVHNFPQSDTYW 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 229 ENLLKICVFIFAFIMPVLIITVCYGLMILRLksvrmLSGSKEKDRnlRRITRMVLVVVAVFIVCWTPIHIYVIIKALITI 308
Cdd:cd15180 162 WLALRLLYHIVGFLLPLAVMVYCYTSILLRL-----LRSSQGFQK--QRAIRVIVAVVVVFFLCWTPYNIALLVDTLIDL 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 84370244 309 -------PETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKR 345
Cdd:cd15180 235 svldrncGTESRLDIALSVTSSLGYFHCCLNPLLYAFVGVKFRR 278
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
69-347 1.84e-42

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 151.82  E-value: 1.84e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISID 147
Cdd:cd14992   1 IILGVALVVIILVSVVGNFIVIAALARHKNLRGATNYFIASLAISDLLmALFCTPFNFTYVVSLSWEYGHFLCKIVNYLR 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 148 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKyRQGS------IDCTLTF 221
Cdd:cd14992  81 TVSVYASSLTLTAIAFDRYFAIIHPLKPRHRQSYTTTVIIIITIWVVSLLLAIPQLYYATTE-VLFSvknqekIFCCQIP 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 222 SHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSvRMLSGSKEKDRNL------RRITRMVLVVVAVFIVCWTP 295
Cdd:cd14992 160 PVDNKTYEKVYFLLIFVVIFVLPLIVMTLAYARISRELWF-RKVPGFSIKEVERkrlkckRRVIKMLVCVVVLFVICWLP 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 84370244 296 IHIYVIIKALITIPETTFQTVSWH-FCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd14992 239 FHLFFLLRDFFPLIMKEKHTLQVYyFLHWIAMSNSMYNPIIYVTLNNNFRKNF 291
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
68-347 4.79e-42

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 150.46  E-value: 4.79e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  68 AITIMAlYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISI 146
Cdd:cd15207   1 VLFIVS-YSLIFLLCVVGNVLVCLVVAKNPRMRTVTNYFILNLAVSDLLvGVFCMPFTLVDNILTGWPFGDVMCKLSPLV 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 147 DYYNMFTSIFTLCTMSVDRYIAVCHPVKalDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTW 226
Cdd:cd15207  80 QGVSVAASVFTLVAIAVDRYRAVVHPTE--PKLTNRQAFVIIVAIWVLALAIMIPQALVLEVKEYQFFRGQTVHICVEFW 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 227 YWENLLKI---CVFIFAFIMPVLIITVCYGLMILRL---KSVRMLSGSKEKD----RNLRRITRMVLVVVAVFIVCWTPI 296
Cdd:cd15207 158 PSDEYRKAyttSLFVLCYVAPLLIIAVLYVRIGYRLwfkPVPGGGSASREAQaavsKKKVRVIKMLIVVVVLFALSWLPL 237
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 84370244 297 HIYVIIKALITIPETTFQTV-SWHFCIA--LGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15207 238 HTVTMLDDFGNLSPNQREVLyVYIYPIAhwLAYFNSCVNPIVYGYFNRNFRKGF 291
7tmA_FPR-like cd15117
N-formyl peptide receptors, member of the class A family of seven-transmembrane G ...
72-344 9.71e-42

N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed at elevated levels on polymorphonuclear and mononuclear phagocytes. FPRs bind N-formyl peptides, which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Activation of FPRs by N-formyl peptides such as N-formyl-Met-Leu-Phe (FMLP) triggers a signaling cascade that stimulates neutrophil accumulation, phagocytosis and superoxide production. These responses are mediated through a pertussis toxin-sensitive G(i) protein that activates a PLC-IP3-calcium signaling pathway. While FPRs are involved in host defense responses to bacterial infection, they can also suppress the immune system under certain conditions. Yet, the physiological role of the FPR family is not fully understood.


Pssm-ID: 320245 [Multi-domain]  Cd Length: 288  Bit Score: 149.50  E-value: 9.71e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  72 MALYSIVCVVGLFGNFLVMYVIVrYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMG-TWPFGTILCKIVISIDYYN 150
Cdd:cd15117   4 LVIYSSAFVLGTLGNGLVIWVTG-FRMTRTVTTVCFLNLAVADFAFCLFLPFSVVYTALGfHWPFGWFLCKLYSTLVVFN 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 151 MFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWY--- 227
Cdd:cd15117  83 LFASVFLLTLISLDRCVSVLWPVWARNHRTPARAALVAVGAWLLALALSGPHLVFRDTRKENGCTHCYLNFDPWNETaed 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 228 WENLLKICV----------FIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKdrnlrritRMVLVVVAVFIVCWTPIH 297
Cdd:cd15117 163 PVLWLETVVqrlsaqvitrFVLGFLVPLVIIGGCYGLIAARLWREGWVHSSRPF--------RVLTAVVAAFFLCWFPFH 234
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 84370244 298 IyVIIKALITIPET-----TFQTVSWHFCIALGYTNSCLNPVLYAFLDENFK 344
Cdd:cd15117 235 L-VSLLELVVILNQkedlnPLLILLLPLSSSLACVNSCLNPLLYVFVGRDFR 285
7tmA_EBI2 cd15159
Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G ...
69-345 1.60e-41

Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2), also called GPR183, is activated by 7alpha, 25-dihydroxyxcholesterol (7alpha, 25-OHC), an oxysterol. EBI2 was originally identified as one of major genes induced in the Burkitt's lymphoma cell line BL41by EBV infection. EBI2 is involved in regulating B cell migration and responses, and is also implicated in human diseases such as type I diabetes, multiple sclerosis, and cancers.


Pssm-ID: 320287 [Multi-domain]  Cd Length: 286  Bit Score: 149.04  E-value: 1.60e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMG-TWPFGTILCKIVISID 147
Cdd:cd15159   1 VLLPLFYSLILVFGLLGNTLALHVICQKRKKINSTTLYLINLAVSDILFTLALPGRIAYYALGfDWPFGDWLCRLTALLF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 148 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCT------LTF 221
Cdd:cd15159  81 YINTYAGVNFMTCLSVDRYIAVVHPLRRHRLRKVKVVRYICVFVWVLVFLQTLPLLFMPMTKEMGGRITCMeypnfeKIK 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 222 SHPTWywenLLKICVfiFAFIMPVLIITVCYGLMILRL-KSVRMLSGSKEKDRNLRRITrMVLVVVAVFIVCWTPIHIYV 300
Cdd:cd15159 161 RLPLI----LLGACV--IGFGVPVGIILFCYSQITLKLcRTAKENPLTEKSGHHKKACN-VILLVLLVFVVCFSPYHLNI 233
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 84370244 301 I---IKALITIP----ETTFQtVSWHFCIALGYTNSCLNPVLYAFLDENFKR 345
Cdd:cd15159 234 IqfmIRKLLYQPscseLKAFK-ISLQITVCLMNLNCCLDPFIYFFACKGYKK 284
7tmA_XCR1 cd15182
XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
73-345 2.33e-41

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 341337 [Multi-domain]  Cd Length: 271  Bit Score: 148.28  E-value: 2.33e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  73 ALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGtWPFGTILCKIVISIDYYNMF 152
Cdd:cd15182   5 VFYYLVFLLSLLGNGLVLWILVKYEKLKTLTNIFILNLAISDLLFTFTLPFWASYHSSG-WIFGEILCKAVTSIFYIGFY 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 153 TSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQgSIDCTLTFSHPTWYWENLL 232
Cdd:cd15182  84 SSILFLTLMTIDRYLAVVHPLSALRSRKLRYASLVSVAVWVISILASLPELILSTVMKSD-EDGSLCEYSSIKWKLGYYY 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 233 KICVFifaFIMPVLIITVCYGLMILRLKSVRMlsgsKEKDRNLRRItrmvLVVVAVFIVCWTPIHIYVIIKALITIPETT 312
Cdd:cd15182 163 QQNLF---FLIPLGIIVYCYVRILQTLMRTRT----MRKHRTVKLI----FVIVLVFFLSWAPYNIVIFLRSLKDLTIPI 231
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 84370244 313 FQTVS-----WHFCIALGYTNSCLNPVLYAFLDENFKR 345
Cdd:cd15182 232 CECSKqldyaFYICRNIAFSHCCLNPVFYVFVGVKFRN 269
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
71-347 5.31e-41

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 147.56  E-value: 5.31e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  71 IMALYSIVCVVGLFGNFLVMYVIV--RYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISID 147
Cdd:cd15002   2 VPILLGVICLLGFAGNLMVIGILLnnARKGKPSLIDSLILNLSAADLLlLLFSVPFRAAAYSKGSWPLGWFVCKTADWFG 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 148 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDfRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWY 227
Cdd:cd15002  82 HACMAAKSFTIAVLAKACYMYVVNPTKQVT-IKQRRITAVVASIWVPACLLPLPQWLFRTVKQSEGVYLCILCIPPLAHE 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 228 WENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHI---YVI-IK 303
Cdd:cd15002 161 FMSAFVKLYPLFVFCLPLTFALFYFWRAYGQCQRRGTKTQNLRNQIRSRKLTHMLLSVVLAFTILWLPEWVawlWLIhIK 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 84370244 304 ALITIPETTFQTVSWhfciALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15002 241 SSGSSPPQLFNVLAQ----LLAFSISSVNPIIFLLMSEEFREGF 280
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
71-345 3.07e-40

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 145.56  E-value: 3.07e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  71 IMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATS-TLPFQSVNYLMGTWPFGTILCKIVISIDYY 149
Cdd:cd15389   3 LIVAYSIIIVISLFGNSLVCHVIFKNKRMHTATNLFIVNLAVSDILITLlNTPFTLVRFVNSTWVFGKIMCHLSRFAQYC 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 150 NMFTSIFTLCTMSVDRYIAVCHPVKAldfR-TPRNAKIVNVCNWILSSAIGLP------VMFMATTKYRQGSIdCTLTFS 222
Cdd:cd15389  83 SVYVSTLTLTAIALDRHRVILHPLKP---RiTPCQGVVVIAIIWIMASCLSLPhaiyqkLVEFEYSNERTRSR-CLPSFP 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 223 HPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEK-----DRNLRRITRMVLVVVAVFIVCWTPIH 297
Cdd:cd15389 159 EPSDLFWKYLDLATFILQYVLPLLIIGVAYTRVAKKLWLRNAIGDVTTEqyvaqRRKKKKTIKMLMLVVLLFAICWLPLN 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 84370244 298 IYVIIkalitipeTTFQTVSWH-----FCIALGYTNSCLNPVLYAFLDENFKR 345
Cdd:cd15389 239 CYHVL--------LSSHPIRSNsalffAFHWLAMSSTCYNPFIYCWLNDSFRS 283
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
71-344 7.56e-40

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 144.51  E-value: 7.56e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  71 IMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMG-TWPFGTILCKIVISIDYY 149
Cdd:cd15191   3 IPVLYSIIFILGFLGNSLVVCVFCHQSGPKTVASIYIFNLAVADLLFLATLPLWATYYSYGyNWLFGSVMCKICGSLLTL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 150 NMFTSIFTLCTMSVDRYIAVCHPVKALDfRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQ--GSIDCTLTF-SHPTW 226
Cdd:cd15191  83 NLFASIFFITCMSVDRYLAVVYPLRSQR-RRSWQARLVCLLVWVLACLSSLPTFYFRDTYYIEelGVNACIMAFpNEKYA 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 227 YWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKekdRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALI 306
Cdd:cd15191 162 QWSAGLALMKNTLGFLIPLIVIATCYFGIGRHLLKTKGFGKNK---QRRDKVLKMVAAVVLAFLICWFPFHVLTFLDALA 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 84370244 307 TIPETTFQTVSWH------FCIALGYTNSCLNPVLYAFLDENFK 344
Cdd:cd15191 239 RMGVINNCWVITVidkalpFAICLGFSNSCINPFLYCFVGNHFR 282
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
69-347 9.05e-40

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 144.20  E-value: 9.05e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKM-KTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCKIVISI 146
Cdd:cd15097   1 VIVPVVFSLIFLLGTVGNSLVLAVLLRSGQSgHNTTNLFILNLSVADlCFILFCVPFQATIYSLEGWVFGSFLCKAVHFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 147 DYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMfmatTKYRQGSIDcTLTFSHPTW 226
Cdd:cd15097  81 IYLTMYASSFTLAAVSVDRYLAIRYPLRSRELRTPRNAVAAIALIWGLSLLFAGPYL----SYYDLIDYA-NSTVCMPGW 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 227 YWEN--LLKICVFIFAFIMPVLIITVCYGLMILRL-KSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIK 303
Cdd:cd15097 156 EEARrkAMDTCTFAFGYLIPVLVVSLSYTRTIKYLwTAVDPLEAMSESKRAKRKVTKMIIIVTALFCLCWLPHHVVILCY 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 84370244 304 ALITIP--ETTFQTVSWHFCIAlgYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15097 236 LYGDFPfnQATYAFRLLSHCMA--YANSCLNPIVYALVSKHFRKGF 279
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
70-344 1.10e-39

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 144.12  E-value: 1.10e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  70 TIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYY 149
Cdd:cd14999   1 AIGTVLSLMCVVGVAGNVYTLVVMCLSMRPRASMYVYILNLALADLLYLLTIPFYVSTYFLKKWYFGDVGCRLLFSLDFL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 150 NMFTSIFTLCTMSVDRYIAVCHPVKALDfRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYwE 229
Cdd:cd14999  81 TMHASIFTLTVMSTERYLAVVKPLDTVK-RSKSYRKLLAGVIWLLSLLLTLPMAIMIRLVTVEDKSGGSKRICLPTWS-E 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 230 NLLKICV---FIFAFIMPVLIITVCYGLMILRL-KSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIK-- 303
Cdd:cd14999 159 ESYKVYLtllFSTSIVIPGLVIGYLYIRLARKYwLSQAAASNSSRKRLPKQKVLKMIFTIVLVFWACFLPFWIWQLLYly 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 84370244 304 -ALITIPETTFQTVSWhFCIALGYTNSCLNPVLYAFLDENFK 344
Cdd:cd14999 239 sPSLSLSPRTTTYVNY-LLTCLTYSNSCINPFLYTLLTKNYK 279
7tmA_P2Y2 cd15373
P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
75-345 3.68e-39

P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y2 belongs to the P2Y receptor family of purinergic G-protein coupled receptors and is implicated to play a role in the control of the cell cycle of endometrial carcinoma cells. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320495 [Multi-domain]  Cd Length: 283  Bit Score: 142.58  E-value: 3.68e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  75 YSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGT-WPFGTILCKIVISIDYYNMFT 153
Cdd:cd15373   7 YGIVFVVGLVLNILALYVFLFRTKPWNASTTYMFNLAISDTLYVLSLPLLVYYYADENdWPFSEALCKIVRFLFYTNLYC 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 154 SIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLK 233
Cdd:cd15373  87 SILFLLCISVHRFLGVCYPVRSLRWLKVRYARIVSVVVWVIVLACQSPVLYFVTTSDKGGNITCHDTSSPELFDQFVVYS 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 234 ICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRnlRRITRMVLVVVAVFIVCWTPIHI-----YVIIKALITI 308
Cdd:cd15373 167 SVMLVLLFCVPFVVILVCYALMVRKLLKPSAGTSTNSRSK--KKSVKMIIIVLAVFILCFLPFHVtrtlyYSFRSMDLSC 244
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 84370244 309 PETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKR 345
Cdd:cd15373 245 GTLNAINLAYKVTRPLASANSCLDPILYFLAGQSFRS 281
7tmA_CysLTR1 cd15158
cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G ...
74-346 6.26e-39

cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320286 [Multi-domain]  Cd Length: 285  Bit Score: 142.19  E-value: 6.26e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  74 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYL-MGTWPFGTILCKIVISIDYYNMF 152
Cdd:cd15158   6 LYSVITVFGLVGNGFALYVLIKTYRQKSAFHIYMLNLAVSDLLCVCTLPLRVVYYVhKGQWLFGDFLCRISSYALYVNLY 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 153 TSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCtltFSHP--TWYWEN 230
Cdd:cd15158  86 CSIYFMTAMSFTRFLAIVFPVQNLNLVTVKKARIVCVGIWIFVTLTSSPFLMSGSHDTETNKTKC---FEPPqsNQQLTK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 231 LLKICVF--IFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRnlRRITRMVLVVVAVFIVCWTP------IHIYVII 302
Cdd:cd15158 163 LLVLNYIslVVGFIIPFLVILICYAMIIRTLLKNTMKARKQQSSR--KKAIRMIIIVLLAFLVSFMPyhiqrtIHLHFLS 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 84370244 303 KALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRC 346
Cdd:cd15158 241 RKDSTCEEVLYMQKSVVITLCLAAANCCFDPLLYFFSGENFRRR 284
7tmA_GPR1 cd15119
G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane ...
72-344 7.19e-39

G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 1 (GPR1) belongs to the class A of the seven transmembrane domain receptors. This is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1. GPR1 is most closely related to another chemerin receptor CMKLR1. In an in-vitro study, GPR1 has been shown to act as a co-receptor to allow replication of HIV viruses.


Pssm-ID: 320247 [Multi-domain]  Cd Length: 278  Bit Score: 141.80  E-value: 7.19e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  72 MALYSIVCVVGLFGNFLVMYVIVRYTKmKTATNIYIFNLALADALATSTLPFQSVNYLMG-TWPFGTILCKIVISIDYYN 150
Cdd:cd15119   4 IVIYIVAFVLGVPGNAIVIWVTGFKWK-KTVNTLWFLNLAIADFVFVLFLPLHITYVALDfHWPFGVWLCKINSFVAVLN 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 151 MFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVM-FMATTKYRQGSIDCTLTF----SHPT 225
Cdd:cd15119  83 MFASVLFLTVISLDRYISLAHPVWSHRYRTLKSALILCGIVWLSAAAISGPALyFRDTMELSINVTICFNNFhkhdGDLI 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 226 WYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKekdrnlrrITRMVLVVVAVFIVCWTPIHIYVIIKAL 305
Cdd:cd15119 163 VMRHTILVWVRFFFGFLFPLLTMVVCYSLLAIKVKRRTLLISSK--------FFWTISAVIVAFFVCWTPYHIFSILELS 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 84370244 306 ITIPETTFQTVSWHFCIA--LGYTNSCLNPVLYAFLDENFK 344
Cdd:cd15119 235 IHHSSYLHNVLRAGIPLAtsLAFINSCLNPILYVLIGKKFK 275
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
77-345 1.30e-38

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 141.07  E-value: 1.30e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  77 IVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMG-TWPFGTILCKIVISIDYYNMFTSI 155
Cdd:cd15189   9 SLCLFGLLGNLFVLLVFLLHRRRLTVAEIYLGNLAAADLVFVSGLPFWAMNILNQfNWPFGELLCRVVNGVIKVNLYTSI 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 156 FTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKY--RQGSIDCTLTFSHPTWYWENLLK 233
Cdd:cd15189  89 YLLVMISQDRYLALVKTMAARRLRRRRYAKLICVLIWVVGLLLSIPTFLLRKIKAipDLNITACVLLYPHEAWHFAHIVL 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 234 ICvfIFAFIMPVLIITVCyGLMILRLKSVRMLSGSKEkDRNLRRITRMVLVVVAVFIVCWTPIHIYVI------IKALIT 307
Cdd:cd15189 169 LN--IVGFLLPLLVITFC-NYNILQALRTREESTRCE-DRNDSKATALVLAVTLLFLVCWGPYHFFTFldflfdVGVLDE 244
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 84370244 308 IPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKR 345
Cdd:cd15189 245 CFWEHFIDIGLQLAVFLAFSNSCLNPVLYVFVGRYFRR 282
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
71-347 1.44e-38

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 141.76  E-value: 1.44e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  71 IMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST-LPFQSVNYLMGTWPFGTILCKIVISIDYY 149
Cdd:cd15208   3 LIALYILVFIVGLVGNVLVCFAVWRNHHMRTVTNYFIVNLSLADFLVIIIcLPATLLVDVTETWFFGQVLCKIIPYLQTV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 150 NMFTSIFTLCTMSVDRYIAVCHPVKalDFRTPRNAKIVNVCNWILSSAIGLP---VMFMATTKYRQGSIDcTLTFSHPTW 226
Cdd:cd15208  83 SVSVSVLTLSCIALDRWYAICHPLM--FKSTAKRARVSILIIWIVSLLIMIPqaiVMECSRVVPLANKTI-LLTVCDERW 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 227 YWENLLK---ICVFIFAFIMPVLIITVCYgLMILRLKSVRMLSGSKEKD-------------------RNLRRITRMVLV 284
Cdd:cd15208 160 SDSIYQKvyhICFFLVTYLLPLCLMILAY-FQIFRKLWCRQIPGTSSVVqrkwnkprksavaaeekqlRSRRKTAKMLIV 238
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 84370244 285 VVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIA--LGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15208 239 VVIMFAICYLPVHLLNILRYVFGLFTVDRETIYAWFLFShwLVYANSAINPIIYNFMSGKFREEF 303
7tmA_CysLTR2 cd15157
cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G ...
75-344 5.45e-38

cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320285 [Multi-domain]  Cd Length: 278  Bit Score: 139.46  E-value: 5.45e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  75 YSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGT-WPFGTILCKIVISIDYYNMFT 153
Cdd:cd15157   7 YLIIFVLGVVGNGLSIYVFLQPSKKKTSVNIFMLNLAVSDLMFVSTLPFRADYYLMGShWVFGDIACRIMSYSLYVNMYC 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 154 SIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYrqGSIDCTLTFSHPTWYWENLLK 233
Cdd:cd15157  87 SIYFLTVLSIVRFLAIVHPFKLWKVTSIKYARILCAVIWIFVMAASSPLLSKGTSKY--NSQTKCLDLHPSKIDKLLILN 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 234 ICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSgSKEKDRNlRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIP---- 309
Cdd:cd15157 165 YIVLVVGFILPFCTLSICYILIIKALLKPRVPQ-SKLRVSH-KKALLTIIITLILFLLCFLPYHILRTVHLMQWSEgqcn 242
                       250       260       270
                ....*....|....*....|....*....|....*
gi 84370244 310 ETTFQTVSWHFCIALgyTNSCLNPVLYAFLDENFK 344
Cdd:cd15157 243 LRLHKAVVITLCLAA--ANSCLDPLLYYFAGENFK 275
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
71-347 5.51e-38

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 139.71  E-value: 5.51e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  71 IMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALA-TSTLPFQSVNYLMGTWPFGTILCKIVISIDYY 149
Cdd:cd15927   3 VPILFALIFLVGVLGNGTLILIFLRNKSMRNVPNIFILSLALGDLLLlLTCVPFTSTIYTLDSWPFGEFLCKLSEFLKDT 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 150 NMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTF--SHPTWY 227
Cdd:cd15927  83 SIGVSVFTLTALSADRYFAIVNPMRKHRSQATRRTLVTAASIWIVSILLAIPEAIFSHVVTFTLTDNQTIQIcyPYPQEL 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 228 WENLLKICV---FIFAFIMPVLIITVCYGLMILRL-KSVRML-----SGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHI 298
Cdd:cd15927 163 GPNYPKIMVllrFLVYYLIPLLIIGVFYVLMARHLiRSTRNIgsgqnQAAQRQIEARKKVAKTVLAFVVLFAVCWLPRHV 242
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 84370244 299 YVIIKALITIPETTFQTVsWH------FCiaLGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15927 243 FMLWFHFAPNGLVDYNAF-WHvlkivgFC--LSFINSCVNPVALYLLSGSFRRHF 294
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
74-347 7.94e-38

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 139.17  E-value: 7.94e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  74 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGT-WPFGTILCKIVISIDYYNMF 152
Cdd:cd15921   6 AYILIFILGLTGNSISVYVFLSQYRSQTPVSVLMVNLAISDLLLVCTLPLRLTYYVLNShWPFGDIACRIILYVLYVNMY 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 153 TSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCtLTFSHPTWYWENLL 232
Cdd:cd15921  86 SSIYFLTALSVFRYLALVWPYLYLRVQTHSVAGIICGLIWILMGLASSPLLFAKSKQHDEGSTRC-LELAHDAVDKLLLI 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 233 KICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRnlRRITRMVLVVVAVFIVCWTPIH----IYVIIKALITI 308
Cdd:cd15921 165 NYVTLPVGFVVPFMTVIFCYIFIIKNLLKPSPALGRTRPSR--RKACALIIISLGIFLVCFLPYHivrtIHLITERQIKE 242
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 84370244 309 PETTFQTVSWHFCI--ALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15921 243 SCGYILRVRKAAVItlCLAASNSCFDPLLYFFVGENFRSRL 283
7tmA_CCR9 cd15174
CC chemokine receptor type 9, member of the class A family of seven-transmembrane G ...
73-345 1.06e-37

CC chemokine receptor type 9, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR9 is a homeostatic receptor specific for CCL25 (formerly known as thymus expressed chemokine) and is highly expressed on both immature and mature thymocytes as well as on intestinal homing T Lymphocytes and mucosal Lymphocytes. In cutaneous melanoma, activation of CCR9-CCL25 has been shown to stimulate metastasis to the small intestine. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 320302 [Multi-domain]  Cd Length: 280  Bit Score: 138.73  E-value: 1.06e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  73 ALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGtWPFGTILCKIVISIDYYNMF 152
Cdd:cd15174   5 PLYWLIFLVGAVGNSLVVLIYTYYRRRKTMTDVYLLNLAIADLLFLCTLPFWATAASSG-WVFGTFLCKVVNSMYKINFY 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 153 TSIFTLCTMSVDRYIAVCHPVKALDFRTPR--NAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTfshptwYWEN 230
Cdd:cd15174  84 SCMLLLTCISVDRYIAIVQATKAHNSKNKRllYSKLVCFFVWLLSTILSLPEILFSQSKEEESVTTCTMV------YPSN 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 231 L---LKICVF----IFAFIMPVLIITVCYGLMILRLKSVRmlsgSKEKDRNLRRITRMVLVVVAVFIvcwtPIHIYVIIK 303
Cdd:cd15174 158 EsnrFKVAVLalkvTVGFFLPFVVMVICYTLIIHTLLQAK----RFQKHKALKVIIAVVTVFVLSQL----PYNSILLIK 229
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 84370244 304 AL----ITIPE-TTFQTVSWHFCI--ALGYTNSCLNPVLYAFLDENFKR 345
Cdd:cd15174 230 TInaynITITDcATSQNLDIAGQVtqSIAFLHSCLNPFLYVFVGVRFRK 278
7tmA_RNL3R2 cd15925
relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G ...
69-345 2.84e-37

relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R2 is also known as GPR100, GPR142, and relaxin family peptide receptor 4 (RXFP4). Insulin-like peptide 5 (INSL5) is an endogenous ligand for RNL3R2 and plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. RNL3R2 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation.


Pssm-ID: 320591 [Multi-domain]  Cd Length: 283  Bit Score: 137.70  E-value: 2.84e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVI-VRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMG-TWPFGTILCKIVISI 146
Cdd:cd15925   1 ILVALAYGLVCAIGLLGNLAVMYLLrNCARRAPPPIDVFVFNLALADFGFALTLPFWAVESALDfHWPFGGAMCKMVLTA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 147 DYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFshPTW 226
Cdd:cd15925  81 TVLNVYASVFLLTAMSVTRYWVVASAAGPGTHLSTFWAKIITLALWAAALLATVPTAIFATEGEVCGVELCLLKF--PSN 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 227 YWENLLKICVFIFAFIMPVLIITVCYgLMILRLKSVRMLSGSKEKDRnlRRITRMVLVVVAVFIVCWTPIHIYVIIKALI 306
Cdd:cd15925 159 YWLGAYHLQRVVVAFVVPLGVITTSY-LLLLSFLQQHKVNQNNRQRQ--SVIARSVRLVVASFFLCWFPNHVVTFWGVLV 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 84370244 307 TIPET-------TFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKR 345
Cdd:cd15925 236 KFRAVpwnstfyFIHTYVFPVTTCLAHSNSCLNPVLYCLMRREFRQ 281
7tmA_CCR1 cd15183
CC chemokine receptor type 1, member of the class A family of seven-transmembrane G ...
74-345 5.56e-37

CC chemokine receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR1 is widely expressed on both hematopoietic and non-hematopoietic cells and binds to the inflammatory CC chemokines CCL3, CCL5, CCL6, CCL9, CCL15, and CCL23. CCR1 activates the typical chemokine signaling pathway through the G(i/o) type of G proteins, causing inhibition of adenylate cyclase and stimulation of phospholipase C, PKC, calcium flux, and PLA2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320311 [Multi-domain]  Cd Length: 278  Bit Score: 136.54  E-value: 5.56e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  74 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFT 153
Cdd:cd15183   6 LYSLVFIIGVVGNVLVVLVLIQHKRLRNMTSIYLFNLAISDLVFLFTLPFWIDYKLKDDWIFGDAMCKFLSGFYYLGLYS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 154 SIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWY-WENLL 232
Cdd:cd15183  86 EIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIITWALAILASMPCLYFFKSQWEFTHHTCSAHFPRKSLIrWKRFQ 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 233 KICVFIFAFIMPVLIITVCYGLMILRLksVRMLSGSKEKdrnlrrITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETT 312
Cdd:cd15183 166 ALKLNLLGLILPLLVMIICYTGIINIL--LRRPNEKKAK------AVRLIFVITLLFFLLWTPYNLAAFVSAFQDVLFTP 237
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 84370244 313 FQTVSWHFCIA------LGYTNSCLNPVLYAFLDENFKR 345
Cdd:cd15183 238 SCEQSQQLDLAlqvtevIAYTHCCVNPVIYVFVGERFRK 276
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
69-347 6.57e-37

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 136.57  E-value: 6.57e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISID 147
Cdd:cd14969   1 YVLAVYLSLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLmSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 148 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFrTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGS-IDCTltfshPTW 226
Cdd:cd14969  81 TFLGLVSISTLAALAFERYLVIVRPLKAFRL-SKRRALILIAFIWLYGLFWALPPLFGWSSYVPEGGgTSCS-----VDW 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 227 YWENLLK----ICVFIFAFIMPVLIITVCYGLMILRLKSV-------RMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTP 295
Cdd:cd14969 155 YSKDPNSlsyiVSLFVFCFFLPLAIIIFCYYKIYRTLRKMskraarrKNSAITKRTKKAEKKVAKMVLVMIVAFLIAWTP 234
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 84370244 296 ---IHIYVIIKALITIPeTTFQTVSWHFcialGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd14969 235 yavVSLYVSFGGESTIP-PLLATIPALF----AKSSTIYNPIIYVFMNKQFRRAL 284
7tmA_CCR8 cd15187
CC chemokine receptor type 8, member of the class A family of seven-transmembrane G ...
74-345 1.31e-36

CC chemokine receptor type 8, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR8, the receptor for the CC chemokines CCL1 and CC16, is highly expressed on allergen-specific T-helper type 2 cells, and is implicated in the pathogenesis of human asthma. CCL1- and CCR8-expressing CD4+ effector T lymphocytes are shown to have a critical role in lung mucosal inflammatory responses. CCR8 is also a functional receptor for CCL16, a liver-expressed CC chemokine that involved in attracting lymphocytes, dendritic cells, and monocytes. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320315 [Multi-domain]  Cd Length: 276  Bit Score: 135.70  E-value: 1.31e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  74 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSvNYLMGTWPFGTILCKIVISIDYYNMFT 153
Cdd:cd15187   6 LYCLLFVFGLLGNSLVIWVLVACKKLRSMTDVYLLNLAASDLLFVFSLPFQA-YYLLDQWVFGNAMCKIVSGAYYIGFYS 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 154 SIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLK 233
Cdd:cd15187  85 SMFFITLMSIDRYLAIVHAVYALKVRTASHGTILSLALWLVAILASVPLLVFYQVASEDGRLQCIPFYPGQGNSWKVFTN 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 234 ICVFIFAFIMPVLIITVCYGLMILRLKsvrmlsgsKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITI----- 308
Cdd:cd15187 165 FEVNILGLLIPFSILIFCYHNILRNLR--------RCHNQNKTKAIKLVFIVVIVFFLFWTPFNVVLFLDSLHSLhiidg 236
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 84370244 309 -PETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKR 345
Cdd:cd15187 237 cQNSQRLTLALHLTETISFTHCCLNPVIYAFVGEKFKK 274
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
69-347 1.36e-36

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 136.33  E-value: 1.36e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALA-TSTLPFQSVNYL-MGTWPFGTILCKIVISI 146
Cdd:cd14979   1 VLVTAIYVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLIlLVGLPVELYNFWwQYPWAFGDGGCKLYYFL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 147 DYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSID--------CT 218
Cdd:cd14979  81 FEACTYATVLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCAIPILFLMGIQYLNGPLPgpvpdsavCT 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 219 LTFSHPTwywENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRML-----------SGSKEKDRNLRRITRMVLVVVA 287
Cdd:cd14979 161 LVVDRST---FKYVFQVSTFIFFVLPMFVISILYFRIGVKLRSMRNIkkgtraqgtrnVELSLSQQARRQVVKMLGAVVI 237
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 84370244 288 VFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCI---ALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd14979 238 AFFVCWLPFHAQRLMFSYASKEDTFLFDFYQYLYPisgILFYLSSAINPILYNLMSSRFRVAF 300
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
69-347 2.01e-36

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 135.50  E-value: 2.01e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALA------TSTLPFQSVNylmgTWPFGTILCKI 142
Cdd:cd14997   1 VLVSVVYGVIFVVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVllvcmpVALVETWARE----PWLLGEFMCKL 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 143 VISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKY----RQGSIDCT 218
Cdd:cd14997  77 VPFVELTVAHASVLTILAISFERYYAICHPLQAKYVCTKRRALVIIALIWLLALLTSSPVLFITEFKEedfnDGTPVAVC 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 219 LTFSHPTW---YWenLLKICVFifaFIMPVLIITVCYGLMILRL------KSVRMLSGSKEKDRNLRRITRMVLVVVAVF 289
Cdd:cd14997 157 RTPADTFWkvaYI--LSTIVVF---FVVPLAILSGLYSVICRRLvghpalESRRADAANRHTLRSRRQVVYMLITVVVLF 231
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 84370244 290 IVCWTPI---HIYVIIKALITI----PETTFQTVSwhFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd14997 232 FVCLLPFrvvTLWIIFAPDEDLqalgLEGYLNLLV--FCRVMVYLNSALNPILYNLMSTKFRSAF 294
7tmA_RNL3R1 cd15926
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G ...
69-345 3.53e-36

relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.


Pssm-ID: 320592 [Multi-domain]  Cd Length: 288  Bit Score: 134.64  E-value: 3.53e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVI-VRYTKMKTATNIYIFNLALADALATSTLPFQSV-NYLMGTWPFGTILCKIVISI 146
Cdd:cd15926   1 IIISIVYSVVCALGLVGNLLVLYLMkSKQGWKKSSINLFVTSLAVTDFQFVLTLPFWAVeNALDFTWLFGKAMCKIVSYV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 147 DYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTF---SH 223
Cdd:cd15926  81 TAMNMYASVFFLTAMSVARYHSVASALKSKRRRGCCSAKWLCVLIWVLAILASLPNAIFSTTATVSNEELCLVKFpdnRG 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 224 PTWYWENLLKICVFIFAFIMPVLIITVCYgLMILRLKSVRMLSGSKEKDRNlrRITRMVLVVVAVFIVCWTPIHIYVIIK 303
Cdd:cd15926 161 NAQFWLGLYHAQKVLLGFLIPLGIISLCY-LLLVRFITDKNITGSSTKRRS--KVTKSVTIVVLSFFLCWLPNQALTTWG 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 84370244 304 ALITIPETTF-------QTVSWHFCIALGYTNSCLNPVLYAFLDENFKR 345
Cdd:cd15926 238 ILIKLNVVHFsyeyfttQVYIFPITVCLAHSNSCLNPILYCLMRREFRK 286
7tmA_GPR33 cd15120
orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled ...
69-347 4.65e-36

orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor GPR33, an orphan member of the chemokine-like receptor family, was originally identified as a pseudogene in humans as well as in several apes and rodent species. Although the intact GPR33 allele is still present in a small fraction of the human population, the human GPR33 contains a premature stop codon. The amino acid sequence of GPR33 shares a high degree of sequence identity with the members of the chemokine and chemoattractant receptors that control leukocyte chemotaxis. The human GPR33 is expressed in spleen, lung, heart, kidney, pancreas, thymus, gonads, and leukocytes.


Pssm-ID: 320248 [Multi-domain]  Cd Length: 282  Bit Score: 134.14  E-value: 4.65e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIvRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGT-WPFGTILCKIVISID 147
Cdd:cd15120   1 VLIAVALFVTFLVGLVVNGLYLWVL-GFKMRRTVNTLWFLHLILSNLIFTLILPFMAVHVLMDNhWAFGTVLCKVLNSTL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 148 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVM-FMATTKYRQGSIDCTLTF----- 221
Cdd:cd15120  80 SVGMFTSVFLLTAISLDRYLLTLHPVWSRQHRTNRWASAIVLGVWISAILLSIPYLaFRETRLDEKGKTICQNNYalstn 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 222 --------SHPTWYWenLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEkdrnlrriTRMVLVVVAVFIVCW 293
Cdd:cd15120 160 wesaevqaSRQWIHV--AMFVFRFLLGFLLPFLIITFCYVRMALKMKERGLARSSKP--------FKVMFTAVVSFFVCW 229
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 84370244 294 TPIHIYVIIKALITIPETTFQtVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15120 230 LPYHLHSGLVLTRGRPPSLTD-ITLLLTVGTTCFNTCFTPVLYLFVGENFKKVL 282
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
69-345 4.95e-36

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 134.11  E-value: 4.95e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGT-WPFGTILCKIVISID 147
Cdd:cd15162   1 VFLPAVYTLVFVVGLPANGMALWVLLFRTKKKAPAVIYMANLAIADLLLVIWLPFKIAYHIHGNnWIFGEALCRLVTVAF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 148 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTkYRQGSIDCTLTFSHPTW- 226
Cdd:cd15162  81 YGNMYCSILLLTCISIDRYLAIVHPMGHRRLRARRYALGTCLAIWLLALLVTLPLYLVKQT-IFLPALDITTCHDVLPEq 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 227 ----YWENLLkICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLrritRMVLVVVAVFIVCWTPIHIYVII 302
Cdd:cd15162 160 llvgDWFYYF-LSLAIVGFLIPFILTASCYVATIRTLAALEDENSEKKKKRAI----KLAATVLAIFIICFAPSNLLLLA 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 84370244 303 KALITIPETTFQTV-SWHFCIALGYTNSCLNPVLYAFLDENFKR 345
Cdd:cd15162 235 HYSLISSSGTGHLYfAYLLALCLSTLNSCIDPFIYYFVSKEFRD 278
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
69-345 9.63e-36

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 133.34  E-value: 9.63e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNY-LMGTWPFGTILCKIVISID 147
Cdd:cd15193   1 IYIPILYLIIFFTGLLGNLFVIALMSKRSTTKRLVDTFVLNLAVADLVFVLTLPFWAASTaLGGQWLFGEGLCKLSSFII 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 148 YYNMFTSIFTLCTMSVDRYIAVchpVKALD---FRTPRNAKIVNVCNWILSSAIGLPVMFmattkYR--QGSIDCTLTFS 222
Cdd:cd15193  81 AVNRCSSILFLTGMSVDRYLAV---VKLLDsrpLRTRRCALITCCIIWAVSLVLGIPSLV-----YRnlINESVCVEDSS 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 223 HPTWYWENLLKICVfifAFIMPVLIITVCYGLMILRLKsvRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTP------I 296
Cdd:cd15193 153 SRFFQGISLATLFL---TFVLPLIVILFCYCSILVRLR--RHFHGAKRTGRRRRNSLRIVFAIVTAFVLSWLPfntlkaV 227
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 84370244 297 HIYVIIKALItIPETTFQTVSWHFCIA--LGYTNSCLNPVLYAFLDENFKR 345
Cdd:cd15193 228 RLLLELGGGV-LPCHTTVAIRQGLTITacLAFVNSCVNPLIYSLLDRHFRR 277
7tmA_CCR3 cd15185
CC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
74-345 1.51e-35

CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR3 is a highly promiscuous receptor that binds a variety of inflammatory CC-type chemokines, including CCL11 (eotaxin-1), CCL3L1, CCL5 (regulated on activation, normal T cell expressed and secreted; RANTES), CCL7 (monocyte-specific chemokine 3 or MCP-3), CCL8 (MCP-2), CCL11, CCL13 (MCP-4), CCL15, CCL24 (eotaxin-2), CCL26 (eotaxin-3), and CCL28. Among these, the eosinophil chemotactic chemokines (CCL11, CCL24, and CCL26) are the most potent and specific ligands. In addition to eosinophil, CCR3 is expressed on cells involved in allergic responses, such as basophils, Th2 lymphocytes, and mast cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341339 [Multi-domain]  Cd Length: 278  Bit Score: 132.64  E-value: 1.51e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  74 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFT 153
Cdd:cd15185   6 LYSLVFIVGLLGNVVVVVILIKYRRLRIMTNIYLLNLAISDLLFLFTLPFWIHYVRWNNWVFGHGMCKLLSGFYYLGLYS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 154 SIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWY-WENLL 232
Cdd:cd15185  86 EIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIITWGLAVLAALPEFIFYETQELFEEFLCSPLYPEDTEDsWKRFH 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 233 KICVFIFAFIMPVLIITVCYGLMILRLksvrMLSGSKEKDRNLRRITRMVLVVVAVfivcWTPIHIYVIIKALITIPETT 312
Cdd:cd15185 166 ALRMNIFGLALPLLIMVICYTGIIKTL----LRCPSKKKYKAIRLIFVIMVVFFIF----WTPYNLVLLLSAFQSIFFET 237
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 84370244 313 FQTVSWHFCIA------LGYTNSCLNPVLYAFLDENFKR 345
Cdd:cd15185 238 DCERSKHLDLAmqvtevIAYTHCCINPVIYAFVGERFRK 276
7tmA_CCR5_CCR2 cd15184
CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G ...
74-345 1.63e-35

CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR2 and CCR5 share very high amino acid sequence identity. Both receptors play important roles in the trafficking of monocytes/macrophages and are implicated in the pathogenesis of immunologic diseases (rheumatoid arthritis, celiac disease, and transplant rejection) and cardiovascular diseases (atherosclerosis and autoimmune hepatitis). CCR2 is a receptor specific for members of the monocyte chemotactic protein family, including CCL2, CCL7, and CCL13. Conversely, CCR5 is a major co-receptor for HIV infection and binds many CC chemokine ligands, including CC chemokine ligands including CCL2, CCL3, CCL4, CCL5, CCL11, CCL13, CCL14, and CCL16. CCR2 is expressed primarily on blood monocytes and memory T cells, whereas CCR5 is expressed on antigen-presenting cells (macrophages and dendritic cells) and activated T effector cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341338 [Multi-domain]  Cd Length: 278  Bit Score: 132.57  E-value: 1.63e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  74 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSvNYLMGTWPFGTILCKIVISIDYYNMFT 153
Cdd:cd15184   6 LYSLVFIFGFVGNMLVVLILINCKKLKSMTDIYLLNLAISDLLFLLTLPFWA-HYAANEWVFGNAMCKLLTGLYHIGFFS 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 154 SIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTW-YWENLL 232
Cdd:cd15184  85 GIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVVTWVVAVFASLPGIIFTKSQKEGSHYTCSPHFPPSQYqFWKNFQ 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 233 KICVFIFAFIMPVLIITVCYGLMILRLKSVRmlsgsKEKDRNlrRITRMVLVVVAVFIVCWTPIHIYVIIkalitipeTT 312
Cdd:cd15184 165 TLKMNILGLVLPLLVMIICYSGILKTLLRCR-----NEKKRH--KAVRLIFTIMIVYFLFWAPYNIVLLL--------NT 229
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 84370244 313 FQT--------------VSWHFCIALGYTNSCLNPVLYAFLDENFKR 345
Cdd:cd15184 230 FQEffglnncsssnrldQAMQVTETLGMTHCCINPVIYAFVGEKFRS 276
7tmA_LPAR6_P2Y5 cd15156
lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G ...
74-341 4.09e-35

lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 6 (LPAR6), also known as P2Y5, is a G(i), G(12/13) G protein-coupled receptor that is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively present in serum. LPAR6 plays an important role in maintenance of human hair growth. Thus, mutations in the receptor are responsible for both autosomal recessive wooly hair and hypotrichosis. Phylogenetic analysis of the class A GPCRs shows that LAPR6 (P2Y5) is classified into the cluster consisting of receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production.


Pssm-ID: 320284 [Multi-domain]  Cd Length: 285  Bit Score: 131.90  E-value: 4.09e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  74 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFT 153
Cdd:cd15156   6 VFSMVFVLGLIANCVAIYIFMCTLKVRNETTTYMINLAISDLLFVFTLPFRIFYFVQRNWPFGDLLCKISVTLFYTNMYG 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 154 SIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATT--KYRQGSIDCTLTFSHPTWYwENL 231
Cdd:cd15156  86 SILFLTCISVDRFLAIVYPFRSKTLRTKRNAKIVCAAVWLTVLAGSLPASFFQSTnnQLNNNSETCFENFSSKTWK-TYL 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 232 LKICVFI--FAFIMPVLIITVCYGLMILRLKSVRMLSGSKekdRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIP 309
Cdd:cd15156 165 SKIVIFIeiVGFFIPLILNVTCSTMVLKTLRRPNTLSRSK---LNKKKVLKMIFVHLFIFCFCFIPYNVNLVLYSLVRTQ 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 84370244 310 -------ETTFQTV-SWHFCIALgyTNSCLNPVLYAFLDE 341
Cdd:cd15156 242 tfkncsvVAAVRTMyPITLCIAV--SNCCFDPIVYYFTSE 279
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
70-347 4.14e-35

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 131.36  E-value: 4.14e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  70 TIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISIDY 148
Cdd:cd15206   2 LIIPLYSVIFLLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLlAVFCMPFTLVGQLLRNFIFGEVMCKLIPYFQA 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 149 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKY--RQGSIDCTLTFshPTW 226
Cdd:cd15206  82 VSVSVSTFTLVAISLERYFAICHPLKSRVWQTLSHAYKVIAGIWLLSFLIMSPILVFSNLIPmsRPGGHKCREVW--PNE 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 227 YWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRmlsgskekdrnlRRITRMVLVVVAVFIVCWTPIHIYVIIKALi 306
Cdd:cd15206 160 IAEQAWYVFLDLMLLVIPGLVMSVAYGLISWTLLEAK------------KRVIRMLFVIVVEFFICWTPLYVINTWKAF- 226
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 84370244 307 tIPETTFQTVSW---HFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15206 227 -DPPSAARYVSSttiSLIQLLAYISSCVNPITYCFMNKRFRQAF 269
7tmA_C5aR cd15114
complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of ...
69-345 5.45e-35

complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320242 [Multi-domain]  Cd Length: 274  Bit Score: 130.99  E-value: 5.45e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKmKTATNIYIFNLALADALATSTLPFQSVNYLM-GTWPFGTILCKIVISID 147
Cdd:cd15114   1 VVALVLYAVVFLVGVPGNALVAWVTGFEAK-RSVNAVWFLNLAVADLLCCLSLPILAVPIAQdGHWPFGAAACKLLPSLI 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 148 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLP-VMFMAT-TKYRQGSIDCTLTFSHPT 225
Cdd:cd15114  80 LLNMYASVLLLTAISADRCLLVLRPVWCQNHRRARLAWIACGAAWLLALLLTVPsFIYRRIhQEHFPEKTVCVVDYGGST 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 226 WYwENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGskekdrnlRRITRMVLVVVAVFIVCWTPIHIYVIIKAL 305
Cdd:cd15114 160 GV-EWAVAIIRFLLGFLGPLVVIASCHGVLLVRTWSRRRQKS--------RRTLKVVTAVVVGFFLCWTPYHVVGLIIAA 230
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 84370244 306 ITIPETTFQTV--SWHFCIALGYTNSCLNPVLYAFLDENFKR 345
Cdd:cd15114 231 SAPNSRLLANAlkADPLTVSLAYINSCLNPIIYVVAGRGFRK 272
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
71-347 6.75e-35

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 130.55  E-value: 6.75e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  71 IMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATS-TLPFQSVNYLMG-TWPFGTILCKIVISIDY 148
Cdd:cd15067   2 LGVVLSLFCLVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSiVMPFSILHEMTGgYWLFGRDWCDVWHSFDV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 149 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLP--VMFMATTKYRQGSIDCTLTfSHPTW 226
Cdd:cd15067  82 LASTASILNLCVISLDRYWAITDPISYPSRMTKRRALIMIALVWICSALISFPaiAWWRAVDPGPSPPNQCLFT-DDSGY 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 227 YwenLLKICVfifAFIMPVLIITVCYGlMILRlksvrmlSGSKEkdrnlRRITRMVLVVVAVFIVCWTPIHIYVIIKAL- 305
Cdd:cd15067 161 L---IFSSCV---SFYIPLVVMLFTYY-RIYR-------AAAKE-----QKAAKTLGIVMGVFILCWLPFFVTNILIGFc 221
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 84370244 306 ----ITIPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15067 222 psncVSNPDILFPLVTW-----LGYINSGMNPIIYACSSRDFRRAF 262
7tmA_P2Y6_P2Y3-like cd15968
P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...
75-345 6.84e-35

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320634 [Multi-domain]  Cd Length: 285  Bit Score: 131.05  E-value: 6.84e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  75 YSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGT-WPFGTILCKIVISIDYYNMFT 153
Cdd:cd15968   7 YSFVFLLGLPLNSVVLTRCCRHTKAWTRTAIYMVNLALADLLYALSLPLLIYNYAMRDrWLFGDFMCRLVRFLFYFNLYG 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 154 SIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKY---RQGSIDCTLTFSHPTWYwen 230
Cdd:cd15968  87 SILFLTCISVHRYLGICHPMRPWHKETRRAAWLTCVLVWILVFAQTLPILIFARTGIirnRTVCYDLAPPALFPHYV--- 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 231 LLKICVFIFAFIMPVLIITVCYGLMILRLksVRMLSGSKEKDRNLRRIT-RMVLVVVAVFIVCWTPIH----IYVIIKAL 305
Cdd:cd15968 164 PYGMALTVSGFLLPFSIILWCYCLVVRTL--CRTLGPAEPPAQARRRKSiRTIVTVTLLFALCFLPFHitrtIYLAVRVT 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 84370244 306 ITIPETTFQTVSWHFCIA--LGYTNSCLNPVLYAFLDENFKR 345
Cdd:cd15968 242 PGVPCHVLEAVAACYKITrpLASANSVLNPLLYFLTKKKFGR 283
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
69-347 8.50e-35

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 130.15  E-value: 8.50e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCKIVISID 147
Cdd:cd15059   1 VAISSIVSVVILLIIVGNVLVIVAVLTSRKLRAPQNWFLVSLAVADiLVGLLIMPFSLVNELMGYWYFGSVWCEIWLALD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 148 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMatTKYRQGSID----CTLtfSH 223
Cdd:cd15059  81 VLFCTASIVNLCAISLDRYWSVTQAVEYNLKRTPRRAKAMIAAVWIISAVISLPPLFG--WKDEQPWHGaepqCEL--SD 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 224 PTWYwenLLKICvfIFAFIMPVLIITVCYglmilrlksVRMLSGSKEKDrnlRRITRMVLVVVAVFIVCWTPIHIYVIIK 303
Cdd:cd15059 157 DPGY---VLFSS--IGSFYIPLLIMIIVY---------ARIYRAAKRKE---RRFTLVLGVVMGAFVLCWLPFFFTYPLV 219
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 84370244 304 ALIT---IPETTFQtvswhFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15059 220 VVCKtcgVPELLFK-----FFFWLGYCNSALNPVIYTIFNKDFRRAF 261
7tmA_BK-2 cd15381
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled ...
77-345 1.85e-34

bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320503 [Multi-domain]  Cd Length: 284  Bit Score: 129.89  E-value: 1.85e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  77 IVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMG-TWPFGTILCKIVISIDYYNMFTSI 155
Cdd:cd15381   9 IIFVLGTIENAFVLIVFCLHKSSCTVAEIYLGNLAAADLLLVCCLPFWAINISNGfNWPFGEFLCKSVNAVIYMNLYSSI 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 156 FTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKIC 235
Cdd:cd15381  89 YFLMMVSIDRYLALVKTMSSGRMRRPACAKLNCLIIWMFGLLMSTPMIVFRTVMYFPEYNITACVLDYPSEGWHVALNIL 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 236 VFIFAFIMPVLIITVCYGLMILRLKSVRMlsgSKEKD-RNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALIT---IPET 311
Cdd:cd15381 169 LNVVGFLIPLSIITFCSTQIIQVLRNNKM---QKFKEiQTERKATVLVLAVLLMFFICWLPFHIFTFLDTLHKlglISGC 245
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 84370244 312 TFQTV---SWHFCIALGYTNSCLNPVLYAFLDENFKR 345
Cdd:cd15381 246 RWEDIldiGTQIATFLAYSNSCLNPLLYVIVGKHFRK 282
7tmA_LPAR4 cd15155
lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G ...
73-347 2.30e-34

lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 4 (LPAR4) is a G protein-coupled receptor that binds and is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively found in serum. Phylogenetic analysis of the class A GPCRs shows that LAPR4 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(12/13) proteins, leading to neurite retraction and stress fiber formation, whereas coupling to G(q) protein leads to increases in calcium levels.


Pssm-ID: 320283 [Multi-domain]  Cd Length: 283  Bit Score: 129.66  E-value: 2.30e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  73 ALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMF 152
Cdd:cd15155   5 AVYSVVFILGLITNCASLFVFCFRMKMRNETAIFMTNLAVSDLLFVFTLPFKIFYNFNRHWPFGDSLCKISGTAFLTNIY 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 153 TSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYwENLL 232
Cdd:cd15155  85 GSMLFLTCISVDRFLAIVYPFRSRTIRTRRNSAIVCAGVWILVLSGGISASLFSTTNVSNTSTTCFEGFSKSIWK-TYLS 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 233 KICVFI--FAFIMPVLIITVCYGLMILRLKSVRMLSgskEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPE 310
Cdd:cd15155 164 KITIFIevVGFIIPLLLNLTCSSLVLRTLRKPATLS---QIGTNKEKVLKMILVHVAIFVVCFVPYNSILFLYALVRSQA 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 84370244 311 TT------FQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15155 241 IAncgverFARTMYPITLCLATLNCCFDPFVYYFTSESFQKSF 283
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
69-347 2.81e-34

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 129.76  E-value: 2.81e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALA-TSTLPFQSVNYLMG-TWPFGTILCKIVISI 146
Cdd:cd15134   1 IPITIIYGIIFVTGVVGNLCTCIVIARNRSMHTATNYYLFSLAVSDLLLlILGLPFELYTIWQQyPWVFGEVFCKLRAFL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 147 DYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQ----------GSID 216
Cdd:cd15134  81 SEMSSYASVLTITAFSVERYLAICHPLRSHTMSKLSRAIRIIIAIWIIAFVCALPFAIQTRIVYLEypptsgealeESAF 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 217 CtlTFSHPTWYWENLLKICVFIFaFIMPVLIITVCYGLMILRLKS---VRMLSGSKEKDRN----LRRITRMVLVVVAVF 289
Cdd:cd15134 161 C--AMLNEIPPITPVFQLSTFLF-FIIPMIAIIVLYVLIGLQLRRstlLRRGQRSVSGGRRssqsRRTVLRMLVAVVVAF 237
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 84370244 290 IVCWTPIH----IYVIIKALITIPETTFQTVswhFCIA--LGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15134 238 FICWAPFHaqrlLTVYAKNMTPPYLFINRIL---FYISgvLYYVSSTVNPILYNVMSAKYRQAF 298
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
78-344 2.82e-34

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 129.53  E-value: 2.82e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  78 VCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMG-TWPFGTILCKIVISIDYYNMFTSIF 156
Cdd:cd15380  10 ICFFGLLGNLFVLFVFLLPRRRLTIAEIYLANLAASDLVFVLGLPFWAENIRNQfNWPFGNFLCRVISGVIKANLFISIF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 157 TLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKY--RQGSIDCTLTFSHPTWYWENLLKI 234
Cdd:cd15380  90 LVVAISQDRYRTLVHTMTSRRQRSRRQAQVICLLIWVFGGLLSIPTFLFRSVKHvpDLNISACILLFPHEAWHFARRVEL 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 235 CvfIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETT-- 312
Cdd:cd15380 170 N--IVGFLLPLAAIVFFNFHIIASLRERTEESRKRCGGLKDTKATRLILTLVLMFLVCWTPYHFFAFLDFLFQVEVIQgc 247
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 84370244 313 ----FQTVSWHFCIALGYTNSCLNPVLYAFLDENFK 344
Cdd:cd15380 248 fweeFIDLGLQLANFFAFANSCLNPVIYVFAGKLFR 283
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
70-347 6.66e-34

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 127.86  E-value: 6.66e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  70 TIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISIDY 148
Cdd:cd15061   1 ILISFLILAIIFTIFGNLLVILAVATTRRLRTITNCYIVSLATADLLvGVLVLPLAIIRQLLGYWPLGSHLCDFWISLDV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 149 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPtwyw 228
Cdd:cd15061  81 LLCTASILNLCCISLDRYFAITYPLKYRTKRSRRLAITMILAVWVISLLITSPPLVGPSWHGRRGLGSCYYTYDKG---- 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 229 enlLKICVFIFAFIMPVLIITVCYglmiLRLKSVRMlsgsKEkdrnlRRITRMVLVVVAVFIVCWTPIHIYVIIKALI-- 306
Cdd:cd15061 157 ---YRIYSSMGSFFLPLLLMLFVY----LRIFRVIA----KE-----RKTAKTLAIVVGCFIVCWLPFFIMYLIEPFCdc 220
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 84370244 307 TIPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15061 221 QFSEALSTAFTW-----LGYFNSVINPFIYAFYNKDFRRAF 256
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
73-347 7.60e-34

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 128.57  E-value: 7.60e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  73 ALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNM 151
Cdd:cd15390   5 IVFVVMVLVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLiSAFNTVFNFTYLLYNDWPFGLFYCKFSNFVAITTV 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 152 FTSIFTLCTMSVDRYIAVCHPVKAldfRT-PRNAKIVNVCNWILSSAIGLPVMFMATT--KYRQGSIDCTLTF----SHP 224
Cdd:cd15390  85 AASVFTLMAISIDRYIAIVHPLRP---RLsRRTTKIAIAVIWLASFLLALPQLLYSTTetYYYYTGSERTVCFiawpDGP 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 225 TWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSK----EKDRNLRRITRMVLVVVAVFIVCWTPIHIYV 300
Cdd:cd15390 162 NSLQDFVYNIVLFVVTYFLPLIIMAVAYTRVGVELWGSKTIGENTprqlESVRAKRKVVKMMIVVVVIFAICWLPYHLYF 241
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 84370244 301 IIKALItipettFQTVSWHF-------CIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15390 242 ILTYLY------PDINSWKYiqqiylaIYWLAMSNSMYNPIIYCWMNKRFRYGF 289
7tmA_ACKR2_D6 cd15188
atypical chemokine receptor 2, member of the class A family of seven-transmembrane G ...
73-344 1.92e-33

atypical chemokine receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR2 (also known as D6) binds non-selectively to all inflammatory CC-chemokines, but not to homeostatic CC-chemokines involved in controlling the migration of cells. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320316 [Multi-domain]  Cd Length: 278  Bit Score: 127.21  E-value: 1.92e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  73 ALYSIVCVVGLFGNFLVMYVIVRYT-KMKTATNIYIFNLALADALATSTLPFQSVnYLMGTWPFGTILCKIVISIDYYNM 151
Cdd:cd15188   5 VFYTLVFLLGLAGNLLLFVVLLLYVpKKKKMTEVYLLNLAVSDLLFLVTLPFWAM-YVAWHWVFGSFLCKFVSTLYTINF 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 152 FTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVM-FMATTKYRQGSIDCTLTFSHPTWYWEN 230
Cdd:cd15188  84 YSGIFFVSCMSLDKYLEIVHAQSPHRLRTRRKSLLVLVAVWVLSIALSVPDMvFVQTHHTNNGVWVCHADYGGHHTIWKL 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 231 LLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMlsgskekdRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPE 310
Cdd:cd15188 164 VFQFQQNLLGFLFPLLAMVFFYSRIACVLTRLRP--------PGQGRALRFVAALVVVFFVLWFPYNLTLFLHSLQDLHV 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 84370244 311 TTFQTVSWHFCIALGYTNS------CLNPVLYAFLDENFK 344
Cdd:cd15188 236 IGNCERSRHLDYALQVTESlafvhcCLNPLLYAFVSKRFR 275
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
75-344 2.02e-33

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 127.13  E-value: 2.02e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  75 YSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGT-WPFGTILCKIVISIDYYNMFT 153
Cdd:cd15161   7 YILVFILAFPGNTLALWLFIHDRKSGTPSNVFLMHLAVADLSYVLILPMRLVYHLSGNhWPFGEVPCRLAGFLFYLNMYA 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 154 SIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTfshptwYWEN--- 230
Cdd:cd15161  87 SLYFLACISVDRFLAIVHPVKSMKIRKPLYAHVVCGFLWVIVTVAMAPLLVSPQTVEVNNTTVCLQL------YREKasr 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 231 --LLKICVfifAFIMPVLIITVCYGLMILRLKsvrmlSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHI----YVIIKA 304
Cdd:cd15161 161 gaLVSLAV---AFTIPFVTTVTCYLLIIRSLR-----TGKREEKPLKDKAIKMIILVLTIFLICFVPYHIsryiYILSHN 232
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 84370244 305 LITIPETTFQTVSW--HFCIALGYTNSCLNPVLYAFLDENFK 344
Cdd:cd15161 233 GAGASCSSRRGLALanRITSCLTCLNGALDPVMYFFVAEKFR 274
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
69-347 2.03e-33

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 126.29  E-value: 2.03e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISID 147
Cdd:cd15064   1 VLISVLLSLIILATILGNALVIAAILLTRKLHTPANYLIASLAVADLLvAVLVMPLSAVYELTGRWILGQVLCDIWISLD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 148 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTfSHPTWy 227
Cdd:cd15064  81 VTCCTASILHLCVIALDRYWAITDAVEYAHKRTPKRAAVMIALVWTLSICISLPPLFGWRTPDSEDPSECLIS-QDIGY- 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 228 wenllKICVFIFAFIMPVLIITVCYGlMILRlksvrmlSGSKEkdrnlRRITRMVLVVVAVFIVCWTPIHIYVIIKAL-- 305
Cdd:cd15064 159 -----TIFSTFGAFYIPLLLMLILYW-KIYR-------AAARE-----RKAAKTLGIILGAFIVCWLPFFLVALIVPLcs 220
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 84370244 306 -ITIPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15064 221 hCWIPLALKSFFLW-----LGYFNSLINPLIYTFFNKDFRKAF 258
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
74-345 3.71e-33

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 126.35  E-value: 3.71e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  74 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMG-TWPFGTILCKIVISIDYYNMF 152
Cdd:cd15160   6 VYSFVFVVGLPANCLALWVLYLQIKKENVLGVYLLNLSLSDLLYILTLPLWIDYTANHhNWTFGPLSCKVVGFFFYTNIY 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 153 TSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILssAIGLPVMFMATTKYRQGSIDCTLTFSH---PTWY-W 228
Cdd:cd15160  86 ASIGFLCCIAVDRYLAVVHPLRFRGLRTRRFALKVSASIWVL--ELGTHSVFLGHDELFRDEPNHTLCYEKypmEGWQaS 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 229 ENLLKICVfifAFIMPVLIITVCYgLMILRlkSVRMLSGSKEKDRnlRRITRMVLVVVAVFIVCWTPIHIYVIIKALI-- 306
Cdd:cd15160 164 YNYARFLV---GFLIPLSLILFFY-RRVLR--AVRQSPSLEREEK--RKIIGLLLSIVVIFLLCFLPYHVVLLVRSVIel 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 84370244 307 ------TIPETTFqtVSWHFCIALGYTNSCLNPVLYAFLDENFKR 345
Cdd:cd15160 236 vqnglcGFEKRVF--TAYQISLCLTSLNCVADPILYIFVTEDVRQ 278
7tmA_PD2R2_CRTH2 cd15118
prostaglandin D2 receptor, member of the class A family of seven-transmembrane G ...
74-343 5.07e-33

prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. PD2R2 is involved in mediating chemotaxis of Th2 cells, eosinophils, and basophils generated during allergic inflammatory processes. CRTH2 (PD2R2), but not DP receptor, undergoes agonist-induced internalization which is one of key processes that regulates the signaling of the GPCR.


Pssm-ID: 320246 [Multi-domain]  Cd Length: 284  Bit Score: 126.07  E-value: 5.07e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  74 LYSIVCVVGLFGNFLVMYViVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMG-TWPFGTILCKIVISIDYYNMF 152
Cdd:cd15118   6 LHGIVSTLGIVENLLILWV-VGFRLRRTVISIWILNLALSDLLATLSLPFFTYYLASGhTWELGTTFCRIHSSIFFLNMF 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 153 TSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLP-VMFMATTKYRQGSIDCTLTFS--------- 222
Cdd:cd15118  85 VSGFLLAAISLDRCLLVVKPVWAQNHRNVAAAKKICGVIWAMALINTIPyFVFRDVIERKDGRKLCYYNFAlfspspdnn 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 223 HPTW-YWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRmlsgskekDRNLRRITRMVLVVVAVFIVCWTPIHIYVI 301
Cdd:cd15118 165 HPICkQRQEGLAISKLLLAFLIPLVIIAVSYAVVSLIIRHRC--------RRRPGRFVRLVVSVVVSFALCWAPYHIFSI 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 84370244 302 IKALITIPETTFQTV--SWHFCIALGYTNSCLNPVLYAFLDENF 343
Cdd:cd15118 237 IEVMAHNQHSLRPLViqGLPFATTLAFLNSVLNPVLYVFSCPDF 280
7tmA_CXCR6 cd15173
CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
74-347 6.90e-33

CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR6 binds specifically to the chemokine CXCL16, which is expressed on dendritic cells, monocyte/macrophages, activated T cells, fibroblastic reticular cells, and cancer cells. CXCR6 is phylogenetically more closely related to CC-type chemokine receptors (CCR6 and CCR9) than other CXC receptors. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320301 [Multi-domain]  Cd Length: 270  Bit Score: 125.27  E-value: 6.90e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  74 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGtWPFGTILCKIVISIDYYNMFT 153
Cdd:cd15173   6 MYSVMFVTGLVGNSLVIVIYIFYEKLRTLTDIFLVNLAVADLLFLCTLPFWAYSAAHE-WIFGTVMCKITNGLYTINLYS 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 154 SIFTLCTMSVDRYIAVCHPVKALDFRTPRN--AKIVNVCNWILSSAIGLPvMFMATTKYRQGSIDCTLTFshPTWYWENL 231
Cdd:cd15173  85 SMLILTCITVDRFIVIVQATKAHNCHAKKMrwGKVVCTLVWVISLLLSLP-QFIYSEVRNLSSKICSMVY--PPDAIEVV 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 232 LKICVFIFAFIMPVLIITVCYGLMILRLksvrMLSGSKEKDRNLRRItrmvLVVVAVFIVCWTPIHIYVIIKALITIPET 311
Cdd:cd15173 162 VNIIQMTVGFFLPLLAMIICYSVIIKTL----LHAKGFQKHKSLKII----FVVVAVFILTQLPYNIMKLIRTLHIENTD 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 84370244 312 tfqTVSWHFCI----ALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15173 234 ---STNFKYAIliteAIAYLHACLNPILYAFVGVKFRKNF 270
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
62-347 7.89e-33

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 125.03  E-value: 7.89e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  62 SPSMVTAITIMALYSIvcvvglFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILC 140
Cdd:cd15321   6 TAAIAAAITFLILFTI------FGNVLVIIAVLTSRSLRAPQNLFLVSLAAADILvATLIIPFSLANELMGYWYFRKTWC 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 141 KIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGL-PVMFMATTKYRQGSI-DCT 218
Cdd:cd15321  80 EIYLALDVLFCTSSIVHLCAISLDRYWSVSRAIEYNSKRTPRRIKCIILIVWLIAAVISLpPLIYKGKQKDEQGGLpQCK 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 219 LtfSHPTWYWenllkICVFIFAFIMPVLIitvcyglMILRLKSVRMLSGSKEKdrnlrRITRMVLVVVAVFIVCWTPIHI 298
Cdd:cd15321 160 L--NEEAWYI-----LSSSIGSFFAPCLI-------MILVYLRIYLIAKNREK-----RFTFVLAVVIGVFVLCWFPFFF 220
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 84370244 299 YVIIKALIT----IPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15321 221 SYSLGAICPelckVPHSLFQFFFW-----IGYCNSSLNPVIYTIFNQDFRRAF 268
7tmA_CXCR5 cd15181
CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G ...
75-345 9.33e-33

CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR5 is a B-cell selective receptor that binds specifically to the homeostatic chemokine CXCL13 and regulates adaptive immunity. The receptor is found on all peripheral blood and tonsillar B cells and is involved in lymphocyte migration (homing) to specific tissues and development of normal lymphoid tissue. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341336 [Multi-domain]  Cd Length: 281  Bit Score: 125.25  E-value: 9.33e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  75 YSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGtWPFGTILCKIVISIDYYNMFTS 154
Cdd:cd15181   7 YSLVFLLGVVGNGLVLTILLRRRRSRRTTENYLLHLALADLLLLLTFPFSVVESIAG-WVFGTFLCKLVGAIHKLNFYCS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 155 IFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLP-VMFMATTKYRQGSI-DCTLTFSH-PTWYWENL 231
Cdd:cd15181  86 SLLLACISVDRYLAIVHAIHSYRHRRLRSVHLTCGSIWLVCFLLSLPnLVFLEVETSTNANRtSCSFHQYGiHESNWWLT 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 232 LKICVFIFAFIMPVLIITVCYGLMILRLksvRMLSGSKEKdrnlRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIpET 311
Cdd:cd15181 166 SRFLYHVVGFFLPLLIMGYCYATIVVTL---CQSSRRLQK----QKAIRVAILVTLVFCLCWLPYNIVIFLDTLDDL-KA 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 84370244 312 TFQTVSWH--------FCIALGYTNSCLNPVLYAFLDENFKR 345
Cdd:cd15181 238 VVKNCKLNdlldaaitVTESLGFSHCCLNPILYAFIGVKFRN 279
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
71-344 9.64e-33

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 125.29  E-value: 9.64e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  71 IMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVN-YLMGTWPFGTILCKIVISIDYY 149
Cdd:cd15928   3 VTAVCSVLMLVGASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSDLLIFLVLPLDLYRlWRYRPWRFGDLLCRLMYFFSET 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 150 NMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWE 229
Cdd:cd15928  83 CTYASILHITALSVERYLAICHPLRAKVLVTRGRVKLLIAVIWAVAIVSAGPALVLVGVEHIQGQQTPRGFECTVVNVSS 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 230 NLLKICVFIFA--FIMPVLIITVCYGLMILRLKSVRMLS---GSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKA 304
Cdd:cd15928 163 GLLSVMLWVSTsfFFVPMVCLSLLYGLIGRALWDRRQRSrtaGASRRDNNHRQTVRMLAVIVLAFVLCWLPFHVGRVIFN 242
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 84370244 305 LITIPETTFQTVSWHFCI---ALGYTNSCLNPVLYAFLDENFK 344
Cdd:cd15928 243 HSRASTKHLHYVSQYFNLvsfVLFYLSAAINPILYNLMSKRYR 285
7tmA_CXCR4 cd15179
CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G ...
69-344 1.47e-32

CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR4 is the only known G protein-coupled chemokine receptor for the key homeostatic ligand CXCL12, which is constitutively secreted by bone marrow stromal cells. Atypical chemokine receptor CXCR7 (ACKR3) also binds CXCL12, but activates signaling in a G protein-independent manner. CXCR4 is also a co-receptor for HIV infection and plays critical roles in the development of immune system during both lymphopoiesis and myelopoiesis. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341334 [Multi-domain]  Cd Length: 278  Bit Score: 124.50  E-value: 1.47e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGtWPFGTILCKIVISIDY 148
Cdd:cd15179   1 IFLPTVYSIIFLLGIVGNGLVILVMGYQKKSRTMTDKYRLHLSVADLLFVLTLPFWAVDAAAN-WYFGNFLCKAVHVIYT 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 149 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWY- 227
Cdd:cd15179  80 VNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWLPALLLTVPDLVFAKVSELDDRYICDRIYPEDTFEl 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 228 WENLLKICVFIFAFIMPVLIITVCYGLMILRLksvrmlsgSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALIT 307
Cdd:cd15179 160 WVVAFRFQHILVGLVLPGLVILTCYCIIISKL--------SHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDTFML 231
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 84370244 308 IPETTF-----QTVSWHFCI--ALGYTNSCLNPVLYAFLDENFK 344
Cdd:cd15179 232 LEIIKQscemeQTVHKWISIteALAFFHCCLNPILYAFLGAKFK 275
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
69-347 4.10e-32

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 122.76  E-value: 4.10e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISID 147
Cdd:cd15329   1 VLIGIVLLIIILGTVVGNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLvALLVMPLAIIYELSGYWPFGEILCDVWISFD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 148 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYrqgSIDCTLTFSHPTWY 227
Cdd:cd15329  81 VLLCTASILNLCAISVDRYLVITRPLTYAVKRTPKRMALMIAIVWLLSALISIPPLFGWKNKV---NDPGVCQVSQDFGY 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 228 wenllKICVFIFAFIMPVLIITVCYGlmilrlksvRMLSGSKEKdrnlRRITRMVLVVVAVFIVCWTPIHIYVIIKALI- 306
Cdd:cd15329 158 -----QIYATFGAFYIPLIVMLVLYY---------KIYRAAKSE----RKAIKTLGIIMGAFTLCWLPFFILALLRPFLk 219
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 84370244 307 -----TIPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15329 220 pikcsCIPLWLSRLFLW-----LGYANSFLNPIIYAKFNREFRTPF 260
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
69-347 4.68e-32

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 122.74  E-value: 4.68e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISID 147
Cdd:cd15323   1 AGLAAVVGFLIVFTIVGNVLVVIAVLTSRALRAPQNLFLVSLASADILvATLVMPFSLANELMGYWYFGQVWCNIYLALD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 148 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMfMATTKYRQGSIDCTLTFSHPTWY 227
Cdd:cd15323  81 VLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKAIIVTVWLISAVISFPPL-ISMYRDPEGDVYPQCKLNDETWY 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 228 wenLLKICvfIFAFIMPVLIITVCYglmilrlksVRMLSGSKEKDrnlRRITRMVLVVVAVFIVCWTPI----HIYVIIK 303
Cdd:cd15323 160 ---ILSSC--IGSFFAPCLIMILVY---------IRIYRVAKARE---KRFTFVLAVVMGVFVVCWFPFffsySLYGICR 222
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 84370244 304 ALITIPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15323 223 EACEVPEPLFKFFFW-----IGYCNSSLNPVIYTIFNQDFRRSF 261
7tmA_P2Y4 cd15374
P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled ...
75-345 8.12e-32

P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y4 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320496 [Multi-domain]  Cd Length: 285  Bit Score: 122.99  E-value: 8.12e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  75 YSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYL-MGTWPFGTILCKIVISIDYYNMFT 153
Cdd:cd15374   7 YGLVFVVGLPLNATALWLFIKRMRPWNPTTVYMFHLALSDTLYVLSLPTLIYYYAdHNHWPFGVVACKIVRFLFYANLYC 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 154 SIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLT-----FSHPTWYw 228
Cdd:cd15374  87 SILFLTCISVHRYVGICHPIRALRWVKPRHAYLICASVWLVVTVCLVPNLIFVTTSRKDNITLCHDTtrpeeFDHYVHY- 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 229 enllKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITI 308
Cdd:cd15374 166 ----SSAVMVLLFGIPCLVIVVCYGLMARRLCKPRVGSSRQQGPSSKKRSLKTIIMVLTVFAICFVPFHITRTLYYVARL 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 84370244 309 PETTFQT-----VSWHFCIALGYTNSCLNPVLYAFLDENFKR 345
Cdd:cd15374 242 LKADCDTlniinVTYKVTRPLASANSCLDPILYFLAGDKYRR 283
7tmA_P2Y3-like cd16001
P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G ...
75-345 9.62e-32

P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y3-like proteins are an uncharacterized group that belongs to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320667 [Multi-domain]  Cd Length: 284  Bit Score: 122.56  E-value: 9.62e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  75 YSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLM-GTWPFGTILCKIVISIDYYNMFT 153
Cdd:cd16001   7 YSVVFVLGLPLNGTVLWLSWCRTKRWTCSTIYLVNLAVADLLYVCSLPLLIVNYAMrDRWPFGDFLCKLVRFLFYTNLYG 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 154 SIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLK 233
Cdd:cd16001  87 SILFLTCISVHRFLGVCYPIRSLAYRTRRLAVIGSAATWILVVLQLLPTLVYARTGSINNRTVCYDLTSPDNFGNYFPYG 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 234 ICVFIFAFIMPVLIITVCYGLMILRL--KSVRMLSGSKEKDRNLRRITRMvlvvVAVFIVCWTPIH----IYVIIKALIT 307
Cdd:cd16001 167 MVLTVTGFLIPFLIILLCYCLMIKSLirSEEAAGVGKAARAKSIRTILLV----CGLFALCFVPFHitrtIYLFVRVYLV 242
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 84370244 308 IPETTFQTVS-----WHFCIALgytNSCLNPVLYAFLDENFKR 345
Cdd:cd16001 243 QDCPLLQFVSlaykiWRPLVSF---NSCINPLLYFLSGDSNRL 282
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
66-338 1.26e-31

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 122.21  E-value: 1.26e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  66 VTAITIMalySIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVIS 145
Cdd:cd14975   1 VLGCTLL---SLAFAIGLPGNSFVIWSILIKVKQRSVTMLLVLNLALADLAVLLTLPVWIYFLATGTWDFGLAACKGCVY 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 146 IDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCtlTFSHPT 225
Cdd:cd14975  78 VCAVSMYASVFLITLMSLERFLAVSRPFVSQGWRAKALAHKVLAIIWLLAVLLATPVIAFRHVEETVENGMC--KYRHYS 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 226 WYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGskekdrnlRRITRMVLVVVAVFIVCWTPIHIYVIIKAL 305
Cdd:cd14975 156 DGQLVFHLLLETVVGFAVPFTAVVLCYSCLLRRLRRRRFRRR--------RRTGRLIASVVVAFAACWLPYHVGNLLEVV 227
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 84370244 306 ITIPETTFQTVSW--------HFCIALGYTNSCLNPVLYAF 338
Cdd:cd14975 228 SELIGGSKMAGTLgkvaeagrPIAGALAFLSSSINPLLYAF 268
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
74-345 1.36e-31

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 122.27  E-value: 1.36e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  74 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLP-FQSVNYLMGTWPFGTILCKIVISIDYYNMF 152
Cdd:cd15194   6 LYCLVFLVGAVGNAILMGALVFKRGVRRLIDIFISNLAASDFIFLVTLPlWVDKEVVLGPWRSGSFLCKGSSYIISVNMY 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 153 TSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTwywENLL 232
Cdd:cd15194  86 CSVFLLTCMSLDRYLAIVLPLVSRKFRTKHNAKVCCTCVWMLSCLLGLPTLLSRELKKYEEKEYCNEDAGTPS---KVIF 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 233 KICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGskEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVI------IKALI 306
Cdd:cd15194 163 SLVSLIVAFFLPLLSILTCYCTIIWKLCHHYQKSG--KHQKKLRKSIKIVFIVVAAFVFSWMPFNLFKAlaiasgLQVEV 240
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 84370244 307 TIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKR 345
Cdd:cd15194 241 TCLPYTLAQLGMEVSAPLAFANSCANPFIYYFFDRYIRR 279
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
71-344 1.41e-31

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 121.78  E-value: 1.41e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  71 IMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATnIYIFNLALADALATSTLPFQSVNYLMGT-WPFGTILCKIVISIDYY 149
Cdd:cd15372   3 VPSLYTLVFLVGLPANGLALWVLATQVKRLPST-IFLINLAVADLLLILVLPFKISYHFLGNnWPFGEGLCRVVTAFFYG 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 150 NMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTkYRQGSIDCT-----LTFSHP 224
Cdd:cd15372  82 NMYCSVLLLMCISLDRYLAVVHPFFARTLRSRRFALCMCTAIWLIAAALTLPLTLQRQS-YPLERLNITlchdvLPLDEQ 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 225 TWYWENLLkICVFIFAFIMPVLIITVCYGLMIlrlksvRMLSGSKEKDRNLRRITRMvlvVVAVFIVCWTPIHIYVIIKA 304
Cdd:cd15372 161 DTYLFYYF-ACLAVLGFLLPLVVILFCYGSVL------HTLLRSGQRYGHAMKLTVL---VLVSFVLCFTPSNLLLLLHY 230
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 84370244 305 LITIPETTFQTVSWHF-CIALGYTNSCLNPVLYAFLDENFK 344
Cdd:cd15372 231 SDPTLDDGGNLYIVYMvSLAISTLNSCVDPFIYYYVSEEFR 271
7tmA_CCR10 cd15177
CC chemokine receptor type 10, member of the class A family of seven-transmembrane G ...
73-345 1.47e-31

CC chemokine receptor type 10, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR10 is a homeostatic receptor specific for two C-C motif chemokines, CCL27 and CCL28. Activation of CCR10 by its two ligands mediates diverse activities, ranging from leukocyte trafficking to skin cancer. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341332 [Multi-domain]  Cd Length: 280  Bit Score: 121.81  E-value: 1.47e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  73 ALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGtWPFGTILCKIVISIDYYNMF 152
Cdd:cd15177   5 CVYLVVFVLGLVGNGLVLATHTRYRRLRSMTDVYLLNLALADLLLLLTLPFAAAETLQG-WIFGNAMCKLIQGLYAINFY 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 153 TSIFTLCTMSVDRYIAVCHPVKALDFR--TPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYW-E 229
Cdd:cd15177  84 SGFLFLTCISVDRYVVIVRATSAHRLRpkTLFYSVLTSLIVWLLSILFALPQLIYSRVENRSELSSCRMIFPEVVSRTvK 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 230 NLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRmlsgSKEKDRNLRRITRMVLVVVAVFivcwTPIHIYVIIKALITIP 309
Cdd:cd15177 164 GATALTQVVLGFAIPLIVMAVCYAAIGRTLLAAR----GWERHRALRVIAALVVAFVLFQ----LPYSVVLLLDTADLLA 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 84370244 310 ETTFQTVSW---HFCI----ALGYTNSCLNPVLYAFLDENFKR 345
Cdd:cd15177 236 TLELSCSQSkrkDIALlvtsGLAYVRCCLNPLLYAFVGVRFRR 278
7tmA_CCR7 cd15175
CC chemokine receptor type 7, member of the class A family of seven-transmembrane G ...
73-344 3.68e-31

CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR7 is a major homeostatic receptor responsible for lymph node development and effective adaptive immune responses and plays a critical role in trafficking of dendritic cells and B and T lymphocytes. Its only two ligands, CCL and CCl21, are primarily produced by stromal cells in the T cell zones of lymph nodes and spleen. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341331 [Multi-domain]  Cd Length: 278  Bit Score: 121.03  E-value: 3.68e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  73 ALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYlMGTWPFGTILCKIVISIDYYNMF 152
Cdd:cd15175   5 AMYSVICFLGLLGNGLVILTYIYFKRLKTMTDIYLLNLALADILFLLTLPFWAASA-AKKWVFGEEMCKAVYCLYKMSFF 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 153 TSIFTLCTMSVDRYIAVCHPVKALDFRtPRN---AKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWe 229
Cdd:cd15175  84 SGMLLLMCISIDRYFAIVQAASAHRHR-SRAvfiSKVSSLGVWVLAFILSIPELLYSGVNNNDGNGTCSIFTNNKQTLS- 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 230 NLLKICVFIFAFIMPVLIITVCYGLMILRLksvrMLSGSKEKDRNLRRITRMVLVVVAVFIvcwtPIHIYVIIKALITIP 309
Cdd:cd15175 162 VKIQISQMVLGFLVPLVVMSFCYSVIIKTL----LQARNFEKNKAIKVIIAVVVVFVVFQL----PYNSVMLVSTLSSFK 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 84370244 310 ETTFQ-TVSWHFCIALGYTNS------CLNPVLYAFLDENFK 344
Cdd:cd15175 234 GNTTDcDYSKNLDFALDVTYSlacfrcCLNPFLYAFIGVKFR 275
7tmA_CCR6 cd15172
CC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
74-347 7.80e-31

CC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR6 is the only known receptor identified for the chemokine CCL20 (also known as macrophage inflammatory protein-3alpha, MIP-3alpha). CCR6 is expressed by all mature human B cells, effector memory T-cells, and dendritic cells found in the gut mucosal immune system. CCL20 contributes to recruitment of CCR6-expressing cells to Peyer's patches and isolated lymphoid follicles in the intestine, thereby promoting the assembly and maintenance of organized lymphoid structures. Also, CCL20 expression is highly inducible in response to inflammatory signals. Thus, CCL20 is involved in both inflammatory and homeostatic functions in the immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341330 [Multi-domain]  Cd Length: 281  Bit Score: 119.86  E-value: 7.80e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  74 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYlMGTWPFGTILCKIVISIDYYNMFT 153
Cdd:cd15172   6 IYSLICVVGLIGNSLVVITYAFYKRTKSMTDVYLLNMAIADILFVLTLPFWAVYE-AHQWIFGNFSCKLLRGIYAINFYS 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 154 SIFTLCTMSVDRYIAVCHPVKALDFRTPRNA--KIVNVCNWILSSAIGLPVmFMATTKYRQGSIDCTL-TFSHPTWYWEN 230
Cdd:cd15172  85 GMLLLACISVDRYIAIVQATKSFRLRSRTLAysKLICAAVWLLAILISLPT-FIFSEVYDFGLEEQYVcEPKYPKNSTAI 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 231 LLKICVFI----FAFIMPVLIITVCYGLMILRLKSVRMLSGSKEkdrnlrriTRMVLVVVAVFIVCWTPIHIYVIIKALI 306
Cdd:cd15172 164 MWKLLVLSlqvsLGFFIPLLVMIFCYSFIIKTLLQAQNSQRHKA--------VRVVVAVVLVFLVCQVPYNIVLLIEAIN 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 84370244 307 TIPETTFQT---VSWHFCI--ALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15172 236 LGEQQSCSSekaVAYAKTIteCLAFFHCCLNPVLYAFIGVKFRNYF 281
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
69-347 9.69e-31

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 120.27  E-value: 9.69e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALAT-STLPFQSVNYLMGTWPFGTILCKIVISID 147
Cdd:cd15205   1 TAFVITYVLIFVLALFGNSLVIYVVTRKRAMRTATNIFICSLALSDLLITfFCIPFTLLQNISSNWLGGAFMCKMVPFVQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 148 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTK------YRQGSIDCTLTF 221
Cdd:cd15205  81 STAVVTSILTMTCIAVERHQGIVHPLKMKWQYTNRRAFTMLGLVWIVSVIVGSPMLFVQQLEvkydflYEKRHVCCLERW 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 222 SHPTwyWENLLKICVFIFAFIMPVLIITVCYGLMILRL---------KSVRMLSGSKEKD--RNLRRITRMVLVVVAVFI 290
Cdd:cd15205 161 YSPT--QQKIYTTFILVILFLLPLTTMLFLYSRIGYELwikkrvgdaSVLQTIHGIEMSKisRKKKRAVKMMVTVVLLFA 238
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 84370244 291 VCWTPIHIYVIIKALiTIPETTFQTVSWHFCIA----LGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15205 239 VCWAPFHVVHMMIEY-SNLENKYDGVTIKLIFAivqlIGFSNSFNNPIVYAFMNENFKKNF 298
7tmA_P2Y1 cd15377
P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
73-345 1.48e-30

P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y1 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 341350 [Multi-domain]  Cd Length: 289  Bit Score: 119.63  E-value: 1.48e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  73 ALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGT-WPFGTILCKIVISIDYYNM 151
Cdd:cd15377   5 AVYILVFITGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTdWIFGDAMCKLQRFIFHVNL 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 152 FTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQG-SIDCTLTFSHPTWYWEN 230
Cdd:cd15377  85 YGSILFLTCISVHRYTGVVHPLKSLGRLKKKNAICISVLVWLIVVVAISPILFYSGTGVRKNkTITCYDTTSDEYLRSYF 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 231 LLKICVFIFAFIMPVLIITVCYGlMILRLKSVRMLSGSKEKDRNLRRIT-RMVLVVVAVFIVCWTPIHiyvIIKALITIP 309
Cdd:cd15377 165 IYSMCTTVAMFCVPFILILGCYG-LIVRALIYKDMKYTEENNAPLRRKSiYLVIIVLTVFAVSYLPFH---VMKTLNLRA 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 84370244 310 ETTFQT-----------VSWHFCIALGYTNSCLNPVLYAFLDENFKR 345
Cdd:cd15377 241 RLDFQTpamcafndrvyATYQVTRGLASLNSCVDPILYFLAGDTFRR 287
7tmA_GPR35_55-like cd15923
G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of ...
73-347 1.82e-30

G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily is composed of GPR35, GPR55, and similar proteins. GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. GPR35 couples to G(13) and G(i/o) proteins, whereas GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Recently, lysophosphatidylinositol (LPI) has been identified as an endogenous ligand for GPR55, while several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast.


Pssm-ID: 320589 [Multi-domain]  Cd Length: 273  Bit Score: 118.71  E-value: 1.82e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  73 ALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQsVNYLMGTWPFGTILCKIVISIDYYNMF 152
Cdd:cd15923   5 AIYIPTFVLGLLLNILALWVFCWRLKKWTETNIYMTNLAVADLLLLISLPFK-MHSYRRESAGLQKLCNFVLSLYYINMY 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 153 TSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMAttkyrqGSIDCTLTFSHPTWYWENLL 232
Cdd:cd15923  84 VSIFTITAISVDRYVAIRYPLRARELRSPRKAAVVCAVIWVLVVTISIPYFLLD------SSNEKTMCFQRTKQTESLKV 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 233 KICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKdrnLRRITRMVLVVVAVFIVCWTPIHIYVIIKALI--TIPE 310
Cdd:cd15923 158 FLLLEIFGFLLPLIIMTFCSARVIHTLQKRLDDVGSRSE---TKQCIRVIMANLIVFIVCFLPVHVGFFVKFIVgkSYSC 234
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 84370244 311 TTFQTVSW--HFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15923 235 DSKLIIHFflQSAFCLSDMNCCLDAFCYYFATKEFREAY 273
PHA02638 PHA02638
CC chemokine receptor-like protein; Provisional
63-344 2.75e-30

CC chemokine receptor-like protein; Provisional


Pssm-ID: 165021 [Multi-domain]  Cd Length: 417  Bit Score: 121.66  E-value: 2.75e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244   63 PSMVTAITImaLYSIVCVVGLFGNFLVMyVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLmGTWPFGTILCKi 142
Cdd:PHA02638  95 PSISEYIKI--FYIIIFILGLFGNAAII-MILFCKKIKTITDIYIFNLAISDLIFVIDFPFIIYNEF-DQWIFGDFMCK- 169
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  143 VISIDYY-NMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFM---ATTKYRQGSIDCT 218
Cdd:PHA02638 170 VISASYYiGFFSNMFLITLMSIDRYFAILYPISFQKYRTFNIGIILCIISWILSLIITSPAYFIfeaSNIIFSAQDSNET 249
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  219 LTFSHPTWYWEN----------LLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEkdrnlrriTRMVLVVVAV 288
Cdd:PHA02638 250 ISNYQCTLIEDNeknnisflgrILQFEINILGMFIPIIIFAFCYIKIILKLKQLKKSKKTKS--------IIIVSIIIIC 321
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 84370244  289 FIVCWTPIHIYVIIKALITIpETTFQTVSWHFC--IALGY----------TNSCLNPVLYAFLDENFK 344
Cdd:PHA02638 322 SLICWIPLNIVILFATMYSF-KGFNSIISEHICgfIKLGYammlaeaislTHCCINPLIYTLIGENFR 388
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
80-347 4.06e-30

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 117.69  E-value: 4.06e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  80 VVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST-LPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTL 158
Cdd:cd15326  12 LFAIVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTvLPFSATLEILGYWVFGRIFCDIWAAVDVLCCTASILSL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 159 CTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTfshptwyWENLLKICVFI 238
Cdd:cd15326  92 CAISIDRYIGVRHSLQYPTIVTRKRAILALLGVWVLSTVISIGPLLGWKEPAPPDDKVCEIT-------EEPFYALFSSL 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 239 FAFIMPVLIITVCY-GLMILRLKsvrmLSGSKEKDRNLRRITRMvlvvvavFIVCWTPIHIYVIIKAL---ITIPETTFQ 314
Cdd:cd15326 165 GSFYIPLIVILVMYcRVYIVALK----FSREKKAAKTLGIVVGM-------FILCWLPFFIALPLGSLfshLKPPETLFK 233
                       250       260       270
                ....*....|....*....|....*....|...
gi 84370244 315 TVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15326 234 IIFW-----LGYFNSCLNPIIYPCSSKEFKRAF 261
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
74-344 4.87e-30

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 118.00  E-value: 4.87e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  74 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMF 152
Cdd:cd15391   6 LYQSTIFLSVGGNYSVIVVFYDGRRSRTDLNYYLINLAVSDlIMALFCMPFTFTQIMLGHWVFPAPMCPIVLYVQLVSVT 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 153 TSIFTLCTMSVDRYIAVCHPVKALdfRTPRNAKIVNVCNWILSSAIGLPVMFMATTK----YRQGSIDCTLTFSHPTwYW 228
Cdd:cd15391  86 ASVLTNTAIGIDRFFAVIFPLRSR--HTKSRTKCIIASIWAISFSLSSVQLFAGRTQrygqYSEGRVLCGESWPGPD-TS 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 229 ENLLKICVFIFAFIMPVLIITVCYGLMILRLKSvRMLSGSKEKDRNL------RRITRMVLVVVAVFIVCWTPIHIYVII 302
Cdd:cd15391 163 RSAYTVFVMLLTYIIPLLILTSTYGYVGFRLWN-RTAPGNADKGRDDmqikskRKVIKMLVFVVLMFGICWLPLHLFNLV 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 84370244 303 KALITI----PETTFQTVsWHFCIALGYTNSCLNPVLYAFLDENFK 344
Cdd:cd15391 242 QDFSTVfrnmPQHTTRLI-YGACHWIAMSNSFVNPIIYLFMNDSFR 286
7tmA_P2Y8 cd15368
purinergic receptor P2Y8, member of the class A family of seven-transmembrane G ...
69-345 5.16e-30

purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320490 [Multi-domain]  Cd Length: 281  Bit Score: 117.95  E-value: 5.16e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGT-WPFGTILCKIVISID 147
Cdd:cd15368   1 VILPVVYSLVALISIPGNLFSLWLLCFHTKPKTPSIIFMINLSLTDLMLACFLPFQIVYHIQRNhWIFGKPLCNVVTVLF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 148 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTkYRQGSIDCTLTFSHPTW- 226
Cdd:cd15368  81 YANMYSSILTMTCISIERYLGVVYPMRSMRWRKKRYAVAACIGMWLLVLTALSPLERTDLT-YYVKELNITTCFDVLKWt 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 227 ------YWENLLkICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKdrnlRRITRMVLVVVAVFIVCWTPIHIYV 300
Cdd:cd15368 160 mlpniaAWAAFL-FTLFILLFLIPFIITVYCYVLIILKLVQTSERYGREQK----RRAIYLALIVLLVFITCFAPNNFIL 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 84370244 301 IIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKR 345
Cdd:cd15368 235 LAHMVSRLFYGKSLYHAYKLTLSLSCLNSCLDPFIYYFASKEFRK 279
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
69-345 5.43e-30

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 116.98  E-value: 5.43e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST-LPFQSVNYLMGTWPFGTILCKIVISID 147
Cdd:cd15210   1 YFAAVWGIVFMVVGVPGNLLTVLALLRSKKLRTRTNAFIINLSISDLLFCAFnLPLAASTFLHQAWIHGETLCRVFPLLR 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 148 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWY 227
Cdd:cd15210  81 YGLVAVSLLTLVLITLNRYILIAHPSLYPRIYTRRGLALMIAGTWIFSFGSFLPLWLGIWGRFGLDPKVCSCSILRDKKG 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 228 WENllKICVFIFAFIMPVLIITVCYGLmilrlksvrmlsgskekdRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALIT 307
Cdd:cd15210 161 RSP--KTFLFVFGFVLPCLVIIICYAR------------------REDRRLTRMMLVIFLCFLVCYLPITLVNVFDDEVA 220
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 84370244 308 IPettfqtvsWHFCIA--LGYTNSCLNPVLYAFLDENFKR 345
Cdd:cd15210 221 PP--------VLHIIAyvLIWLSSCINPIIYVAMNRQYRQ 252
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
76-347 5.79e-30

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 117.14  E-value: 5.79e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  76 SIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTS 154
Cdd:cd15050   8 STISLITVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIvGAVVMPLNIVYLLESKWILGRPVCLFWLSMDYVASTAS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 155 IFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPV----MFMATTKYRQGSIDCTLTFSHPTWYwen 230
Cdd:cd15050  88 IFSLFILCIDRYRSVQQPLKYLKYRTKTRASLMISGAWLLSFLWVIPIlgwhHFARGGERVVLEDKCETDFHDVTWF--- 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 231 llKICVFIFAFIMPVLIITVCYGLMilrLKSVRmlsgsKEkdrnlRRITRMVLVVVAVFIVCWTPihiYVIIKALITIPE 310
Cdd:cd15050 165 --KVLTAILNFYIPSLLMLWFYAKI---FKAVN-----RE-----RKAAKQLGFIMAAFILCWIP---YFILFMVIAFCK 226
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 84370244 311 TTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15050 227 NCCNENLHMFTIWLGYINSTLNPFIYPLCNENFKKTF 263
7tmA_P2Y1-like cd15967
P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically ...
73-344 6.72e-30

P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320633 [Multi-domain]  Cd Length: 281  Bit Score: 117.48  E-value: 6.72e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  73 ALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGT-WPFGTILCKIVISIDYYNM 151
Cdd:cd15967   5 PVYILVFVVGLVGNVWGLKSLLANWKKLGNINVFVLNLGLADLLYLLTLPFLVVYYLKGRkWIFGQVFCKITRFCFNLNL 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 152 FTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMatTKYRQGSIDCTLTFSHPtwYWENL 231
Cdd:cd15967  85 YGSIGFLTCISVYRYLAIVHPMRVMGRITTTHSVVISALVWLLVVIQSLPDLFF--SKTNSNGTKCFDTTFND--YLESY 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 232 LK--ICVFIFAFIMPVLIITVCYGLMILrlksvrMLSGSKEKDRNLR-RITRMVLVVVAVFIVCWTPIHIYVIIKALITI 308
Cdd:cd15967 161 LTysLGWTVTGFVIPLLIILGCYGHVVV------VLCRNNNVDKGLKqRCLKLVIILIVLFSVCYIPYHVFRNLNLLSRI 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 84370244 309 PETTFQTVSWHFCIALGYT--------NSCLNPVLYAFLDENFK 344
Cdd:cd15967 235 LQKQGSCTQWFRGIYIAHQvsrglvclNSALNPLVYLMGSEDIL 278
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
74-347 8.22e-30

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 116.68  E-value: 8.22e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  74 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLM-GTWPFGTILCKIVISIDYYNM 151
Cdd:cd15053   6 FLLLLPLLTVFGNVLVIMSVFRERSLQTATNYFIVSLAVADLLvAILVMPFAVYVEVNgGKWYLGPILCDIYIAMDVMCS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 152 FTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMF-MATTKYRqgsidctltfshptwywen 230
Cdd:cd15053  86 TASIFNLCAISIDRYIAVTQPIKYARQKNSKRVLLTIAIVWVVSAAIACPLLFgLNNVPYR------------------- 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 231 LLKICVF----------IFAFIMPVLIITVCYGLMILRLKsvrmlsgsKEkdrnlRRITRMVLVVVAVFIVCWTP---IH 297
Cdd:cd15053 147 DPEECRFynpdfiiyssISSFYIPCIVMLLLYYRIFRALR--------RE-----KKATKTLAIVLGVFLFCWLPfftLN 213
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 84370244 298 I-----YVIIKALITIPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15053 214 IlnaicPKLQNQSCHVGPALFSLTTW-----LGYVNSFLNPIIYTIFNIEFRKAF 263
7tmA_ACKR3_CXCR7 cd14987
CXC chemokine receptor 7, member of the class A family of seven-transmembrane G ...
70-344 1.71e-29

CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR3, also known as CXCR7, is an atypical chemokine receptor for CXCL12 and CXCR11. Unlike the classical chemokine receptors, ACKR3 contains a DRYLSIT-sequence instead of the conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. Thus, ACKR3 does not activate classical GPCR signaling, instead induces beta-arrestin recruitment which is leading to ligand internalization and MAP-kinase activation. It is acting as a scavenger for CXCL12 and, to a lesser degree, for CXCL11. ACKR3 is highly expressed by blood vascular endothelial cells in brain, in numerous embryonic and neonatal tissues, in inflamed tissues and in a variety of cancers such as lymphomas, sarcomas, prostate and breast cancers, and gliomas. Five receptors have been identified for the ACKR family, including CC-Chemokine Receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, DARC, and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320118 [Multi-domain]  Cd Length: 282  Bit Score: 116.40  E-value: 1.71e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  70 TIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYL-MGTWPFGTILCKIVISIDY 148
Cdd:cd14987   2 TLSFFYIFIFVIGLLANSVVVWVNLQAKRTGYETHLYILNLAIADLCVVATLPVWVVSLVqHNQWPMGEFTCKITHLIFS 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 149 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLP-VMFMAT-TKYRQGSIDCTLTF-SHPT 225
Cdd:cd14987  82 INLFGSIFFLTCMSVDRYLSVTLFGNTSSRRKKIVRRIICVLVWLLAFVASLPdTYFLKTvTSPSNNETYCRSFYpEESF 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 226 WYWENLLKICVFIFAFIMPVLIITVCYGLMilrlksVRMLSGSKEKDRNLRRitRMVLVVVAVFIVCWTPIHIYVIIKAL 305
Cdd:cd14987 162 KEWLIGMELVSIVLGFVIPFPIIAVFYFLL------ARAISASSDQERKSSR--KIIFSYVVVFLVCWLPYHTVVLLDIL 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 84370244 306 IT---IPET----TFQTVSWHFCIALGYTNSCLNPVLYAFLDENFK 344
Cdd:cd14987 234 SFlhlIPFScqleNFLYAALHVTQCFSLVHCCVNPILYSFINRNYR 279
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
69-347 2.86e-29

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 115.56  E-value: 2.86e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADA--LATSTLPFQSVNYL-MGTWPFGTILCKIVIS 145
Cdd:cd14995   1 VVATFLVLLICGVGIVGNIMVVLVVLRTRHMRTPTNCYLVSLAVADLmvLVAAGLPNEIESLLgPDSWIYGYAGCLLITY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 146 IDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATT--KYRQGSIDCTLTFSH 223
Cdd:cd14995  81 LQYLGINASSLSITAFTIERYIAICHPMKAQFICTVSRAKKIICFVWIFTSLYCSPWLFLLDLsiKHYGDDIVVRCGYKV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 224 PTWYWENLLKICVFIFaFIMPVLIITVCYGLMilrlksVRMLSGSKekdrnlRRITRMVLVVVAVFIVCWTPIHIYVIIK 303
Cdd:cd14995 161 SRHYYLPIYLADFVLF-YVIPLLLAIVLYGLI------GRILFSSR------KQVTKMLAVVVVLFALLWMPYRTLVVYN 227
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 84370244 304 ALITIPETTfqtvSWH--FCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd14995 228 SFASPPYLD----LWFllFCRTCIYLNSAINPILYNLMSQKFRAAF 269
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
74-347 3.93e-29

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 115.30  E-value: 3.93e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  74 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMF 152
Cdd:cd15979   6 LYSVIFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDlMLAVFCMPFTLIPNLMGTFIFGEVICKAVAYLMGVSVS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 153 TSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKY-----RQGSIDCTLTFSHP--- 224
Cdd:cd15979  86 VSTFSLVAIAIERYSAICNPLQSRVWQTRSHAYRVIAATWLLSGLIMIPYPVYSVTVPvpvgdRPRGHQCRHAWPSAqvr 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 225 -TWYwenllkICVFIFAFIMPVLIITVCYGLMilrlksvrmlsgSKEKDRNL---RRITRMVLVVVAVFIVCWTPIHIYV 300
Cdd:cd15979 166 qAWY------VLLLLILFFIPGVVMIVAYGLI------------SRELYRGLlakKRVIRMLVVIVAMFFLCWLPIFSAN 227
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 84370244 301 IIKALitIPETTFQTVSW---HFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15979 228 TWRAF--DPLSAHRALSGapiSFIHLLSYTSACVNPLVYCFMNRRFRKAF 275
7tmA_GPR55-like cd15165
G protein-coupled receptor 55 and similar proteins, member of the class A family of ...
80-343 4.31e-29

G protein-coupled receptor 55 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR55 shares closest homology with GPR35, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Lysophosphatidylinositol (LPI) is currently considered as the endogenous ligand for GPR55, although the receptor was initially de-orphanized as a cannabinoid receptor and binds many cannabinoid ligands.


Pssm-ID: 320293 [Multi-domain]  Cd Length: 277  Bit Score: 115.12  E-value: 4.31e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  80 VVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMgTWPFGTILCKIVISIDYYNMFTSIFTLC 159
Cdd:cd15165  12 VLGLLLNLMALWVFLFKIKKWTESTIYMINLALNDLLLLLSLPFKMHSSKK-QWPLGRTLCSFLESLYFVNMYGSILIIV 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 160 TMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKyrQGSIDCTLTFSHPTwyWENLLKICVFIF 239
Cdd:cd15165  91 CISVDRYIAIRHPFLAKRLRSPRKAAIVCLTIWVFVWAGSIPIYSFHDKP--TNNTRCFHGFSNKT--WSKKVIVVVEEF 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 240 AFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITrmvLVVVAVFIVCWTPIHI----YVIIKALITIPETTFQT 315
Cdd:cd15165 167 GFLIPMAVMVFCSVQIIRTLLDMRRPEQPKVKQNKSVKIV---LSNLVVFLVCFTPYHLgiflQFLVKNDIINDCSTKQS 243
                       250       260       270
                ....*....|....*....|....*....|
gi 84370244 316 VSW--HFCIALGYTNSCLNPVLYAFLDENF 343
Cdd:cd15165 244 IRLfvQVSMCLANVNCCLDAICYYFILKEF 273
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
69-347 4.83e-29

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 115.12  E-value: 4.83e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISID 147
Cdd:cd15051   1 IVLGVVLAVIILLTVIGNVLVCLAVAVNRRLRNLTNYFIVSLAVTDLLlGLLVLPFSAIYELRGEWPLGPVFCNIYISLD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 148 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIG-LPVMF-MATTKYRQGSIDctltfsHPT 225
Cdd:cd15051  81 VMLCTASILNLFAISLDRYLAITAPLRYPSRVTPRRVAIALAAIWVVSLAVSfLPIHLgWNTPDGRVQNGD------TPN 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 226 ---WYWENLLKICVFIFAFIMPVLIITVCYgLMIL--------RLKSVRMLSGSKEKDRNL----RRITRMVLVVVAVFI 290
Cdd:cd15051 155 qcrFELNPPYVLLVAIGTFYLPLLIMCGVY-LRIFriareqakRINALTPASTANSSKSAAtareHKATVTLAAVLGAFI 233
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 84370244 291 VCWTPIHIYVIIKAL--ITIPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15051 234 ICWFPYFTYFTYRGLcgDNINETALSVVLW-----LGYANSALNPILYAFLNRDFRRAF 287
7tmA_PAR1 cd15369
protease-activated receptor 1, member of the class A family of seven-transmembrane G ...
73-338 6.98e-29

protease-activated receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320491  Cd Length: 281  Bit Score: 114.48  E-value: 6.98e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  73 ALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGT-WPFGTILCKIVISIDYYNM 151
Cdd:cd15369   5 SVYTIVFVISLPLNILALVVFLRKMRVKKPAVIYMLNLACADLLFVLLLPFKIAYHFSGNdWLFGEAMCRVVTAAFYCNM 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 152 FTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKY--RQGSIDC--TLTFSHPTWY 227
Cdd:cd15369  85 YCSILLMTCISVDRFLAVVYPMQSLSWRTLRRASFTCAAIWLLSIAGVVPLLLSEQTIQipDLGITTChdVLNEQLLMGY 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 228 WENLLKICVFIFaFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLrritRMVLVVVAVFIVCWTPIHIYVIIK--AL 305
Cdd:cd15369 165 YVYYFSIFSCLF-FFVPLIITTVCYVSIIRCLSSSSDVANSSKKTRAL----FMAVAVFCVFVICFGPTNVLLLAHyvRF 239
                       250       260       270
                ....*....|....*....|....*....|...
gi 84370244 306 ITIPETTFQTVSWHFCIALGYTNSCLNPVLYAF 338
Cdd:cd15369 240 AYTSTNDASYFAYLLCVCVGSISCCLDPLIYYY 272
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
71-344 1.51e-28

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 113.68  E-value: 1.51e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  71 IMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST-LPFqSVNYLM--GTWPFGTILCKIVISID 147
Cdd:cd15394   3 IIPLYSLVVLVGVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATcVPL-TLAYAFepRGWVFGRFMCYFVFLMQ 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 148 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRtPRNAKIVnVCNWILSSAIGLPVmfMATTKYrqgsIDCT-LTFSHPTW 226
Cdd:cd15394  82 PVTVYVSVFTLTAIAVDRYYVTVYPLRRRISR-RTCAYIV-AAIWLLSCGLALPA--AAHTYY----VEFKgLDFSICEE 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 227 YW-----ENLLKICVFIF-AFIMPVLIITVCYGLMILRLKSvRMLSGS-----KEKDRNLRRIT-RMVLVVVAVFIVCWT 294
Cdd:cd15394 154 FWfgqekQRLAYACSTLLiTYVLPLLAISLSYLRISVKLRN-RVVPGSmtqsqAEWDRARRRKTfRLLVVVVVAFAICWL 232
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 84370244 295 PIHIYVIIKAL-ITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFK 344
Cdd:cd15394 233 PLHIFNVIRDIdIDLIDKQYFNLIQLLCHWLAMSSACYNPFLYAWLHDSFR 283
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
69-342 2.00e-28

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 113.53  E-value: 2.00e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLM--GTWPFGTILCKIVIS 145
Cdd:cd15204   1 IVLGVVYVLIMLVCGVGNLLLIAVLARYKKLRTLTNLLIANLALSDFLvAVFCLPFEMDYYVVrqRSWTHGDVLCAVVNY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 146 IDYYNMFTSIFTLCTMSVDRYIAVCHPVKALdfRTPRNAKIVNVCNWILSSAIGLPV-MFMATTKY-RQGSIDCTLTFS- 222
Cdd:cd15204  81 LRTVSLYVSTNALLVIAIDRYLVIVHPLKPR--MKRRTACVVIALVWVVSLLLAIPSaVYSKTTPYaNQGKIFCGQIWPv 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 223 HPTWYWENLLkICVFIFAFIMPVLIITVCYgLMILRLKSVRMLSGS-----KEKDRNLRRITRMVLVVVAVFIVCWTPIH 297
Cdd:cd15204 159 DQQAYYKAYY-LFLFVLEFVLPVLIMTLCY-LRIVRKVWFRRVPGQqteqiRRRLRRRRRKVRLLVVILTAFVLCWAPYY 236
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 84370244 298 IYVIIK-------ALITIPETTFQTVSwhfCIALGytNSCLNPVLYAFLDEN 342
Cdd:cd15204 237 GYAIVRdffptllSKEKLNTTIFYIVE---ALAMS--NSMINTVVYVAFNNN 283
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
69-347 2.33e-28

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 112.68  E-value: 2.33e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST-LPFQSVNYLMGTWPFGTILCKIVISID 147
Cdd:cd15325   1 IVLGVILGGFILFGVLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTvLPFSAIFEILGYWAFGRVFCNIWAAVD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 148 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTfSHPTWY 227
Cdd:cd15325  81 VLCCTASIMSLCIISIDRYIGVSYPLRYPSIMTERRGLLALLCVWVLSLVISIGPLFGWKEPAPEDETICQIT-EEPGYA 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 228 WENLLKicvfifAFIMPVLIITVCYGLMIlrlksVRMLSGSKEKdrnlrRITRMVLVVVAVFIVCWTPIHIYVIIKAL-- 305
Cdd:cd15325 160 LFSALG------SFYLPLAIILVMYCRVY-----VVALKFSREK-----KAAKTLGIVVGCFVLCWLPFFLVMPIGSIfp 223
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 84370244 306 -ITIPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15325 224 aYKPSDTVFKITFW-----LGYFNSCINPIIYPCSSQEFKKAF 261
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
69-347 2.38e-28

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 113.42  E-value: 2.38e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTL-PFQSVNYLMGTWPFGTILCKIVISID 147
Cdd:cd15055   1 VLLYIVLSSISLLTVLGNLLVIISISHFKQLHTPTNLLLLSLAVADFLVGLLVmPFSMIRSIETCWYFGDTFCKLHSSLD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 148 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAI-GLPVMFMATTKYRQGSI----DCTLTFS 222
Cdd:cd15055  81 YILTSASIFNLVLIAIDRYVAVCDPLLYPTKITIRRVKICICLCWFVSALYsSVLLYDNLNQPGLIRYNscygECVVVVN 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 223 HPTWywenllkICVFIFAFIMPVLIITVCYG-LMILRLKSVRMLSGSKEKDRNLRRITRMVL-----------VVVAVFI 290
Cdd:cd15055 161 FIWG-------VVDLVLTFILPCTVMIVLYMrIFVVARSQARAIRSHTAQVSLEGSSKKVSKkserkaaktlgIVVGVFL 233
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 84370244 291 VCWTPIHIYVIIKALITIPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15055 234 LCWLPYYIVSLVDPYISTPSSVFDVLIW-----LGYFNSCLNPLIYALFYPWFRKAL 285
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
69-349 3.11e-28

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 112.72  E-value: 3.11e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATS-TLPFQSVNYLMGTWPFGTILCKIVISID 147
Cdd:cd15314   1 VLLYIFLGLISLVTVCGNLLVIISIAHFKQLHTPTNYLILSLAVADLLVGGlVMPPSMVRSVETCWYFGDLFCKIHSSFD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 148 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFM---ATTKYRQGSI---DCTLTF 221
Cdd:cd15314  81 ITLCTASILNLCFISIDRYYAVCQPLLYRSKITVRVVLVMILISWSVSALVGFGIIFLelnIKGIYYNHVAcegGCLVFF 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 222 SHPTwywenllKICVFIFAFIMPVLIITVCYG--LMILRlKSVRMLSGSKEKDRNL-----RRITRMVLVVVAVFIVCWT 294
Cdd:cd15314 161 SKVS-------SVVGSVFSFYIPAVIMLCIYLkiFLVAQ-RQARSIQSARTKSGASsskmeRKATKTLAIVMGVFLLCWT 232
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 84370244 295 PIHIYVIIKALI--TIPETTFQTVSWhfciaLGYTNSCLNPVLYAFldenFKRCFRE 349
Cdd:cd15314 233 PFFLCNIIDPFInySIPPVLIEVLNW-----LGYSNSTLNPFIYAF----FYSWFRK 280
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
69-347 4.90e-28

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 111.96  E-value: 4.90e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISID 147
Cdd:cd15322   1 LTLIILVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILvATLVIPFSLANEVMGYWYFGKVWCEIYLALD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 148 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSID-CTLtfSHPTW 226
Cdd:cd15322  81 VLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKKSGQPEGPiCKI--NDEKW 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 227 YwenllKICVFIFAFIMPVLIITVCYglmilrlksVRMLSGSKEKDrnlRRITRMVLVVVAVFIVCWTPIHIYVIIKALI 306
Cdd:cd15322 159 Y-----IISSCIGSFFAPCLIMVLVY---------IRIYQIAKNRE---KRFTFVLAVVIGVFVICWFPFFFTYTLTAVC 221
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 84370244 307 --TIPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15322 222 dcSVPETLFKFFFW-----FGYCNSSLNPVIYTIFNHDFRRAF 259
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
68-347 5.41e-28

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 112.52  E-value: 5.41e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  68 AITIMALYSIVcVVGLFGNFLVMYVIVRYTKMK-TATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTiLCKIVIS 145
Cdd:cd15057   1 IITGCILYLLV-LLTLLGNALVIAAVLRFRHLRsKVTNYFIVSLAVSDLLvAILVMPWAAVNEVAGYWPFGS-FCDVWVS 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 146 IDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIG-LPVMfmaTTKYRQGSIDCTLTFSHP 224
Cdd:cd15057  79 FDIMCSTASILNLCVISVDRYWAISSPFRYERRMTRRRAFIMIAVAWTLSALISfIPVQ---LGWHRADDTSEALALYAD 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 225 ---------TWYwenllKICVFIFAFIMPVLIITVCYGLM-------ILRLKSV-RMLSGSKEKDRNLR-------RITR 280
Cdd:cd15057 156 pcqcdsslnRTY-----AISSSLISFYIPVAIMIVTYTRIyriarrqIRRIAALeRAAQESTNPDSSLRsslrretKALK 230
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 84370244 281 MVLVVVAVFIVCWTPIHIYVII--------KALITIPETTFQTVSWhfciaLGYTNSCLNPVLYAFlDENFKRCF 347
Cdd:cd15057 231 TLSIIMGVFVCCWLPFFILNCVlpfcdlrtAQFPCVPDTTFIVFVW-----LGWANSSLNPIIYAF-NADFRKAF 299
7tmA_OXGR1 cd15375
2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G ...
73-347 9.08e-28

2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; 2-oxoglutarate receptor 1 (OXGR1) is also known as GPR80, GPR99, or P2Y15. OXGR1 functions as a receptor for alpha-ketoglutarate, a citric acid cycle intermediate, and acts exclusively through a G(q)-dependent pathway. OXGR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC). OXGR1 has also been reported as a potential third cysteinyl leukotriene receptor with specificity for leukotriene E4.


Pssm-ID: 320497 [Multi-domain]  Cd Length: 280  Bit Score: 111.71  E-value: 9.08e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  73 ALYSIVCVVGLFGNFLVMYVIVryTKMK--TATNIYIFNLALADALATSTLPFQSVNYLMG-TWPFGTILCKIVISIDYY 149
Cdd:cd15375   5 VMYSIIFIVGFPGNIIAIFVYL--FKMRpwKSSTIIMLNLALTDLLYVTSLPFLIYYYINGeSWIFGEFMCKFIRFIFHF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 150 NMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCT-LTFSHP--TW 226
Cdd:cd15375  83 NLYGSILFLTCFSIFRYVVIVHPLRAFQVQKRRWAIVACAVVWVISLAEVSPMTFLITTKEKNNRTICLdFTSSDNlnTI 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 227 YWENLLkicVFIFAFIMPVLIITVCYGLMILRL-KSVRMLSGSKEKDRnlrritRMVLVVVAVFIVCWTPIHIYVIIK-- 303
Cdd:cd15375 163 WWYNWI---LTVLGFLLPLVIVTLCYTRIIYTLaKGPHTGSASKQKAR------RLIILILLVFYVCFLPFHILRVVRie 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 84370244 304 -ALITIPETTFQTVSWHFCIA--LGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15375 234 tRLPPVSCCLKHQVHAIYIITrpLAALNTFGNLLLYVVSGDNFQQAF 280
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
68-347 1.33e-27

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 110.49  E-value: 1.33e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  68 AITIMALYSIVCVVGlfGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISI 146
Cdd:cd15049   2 LICIATGSLSLVTVG--GNILVILSFRVNRQLRTVNNYFLLSLACADLIiGLVSMNLYTVYLVMGYWPLGPLLCDLWLAL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 147 DYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATT--KYRQGSID-CTLTF-S 222
Cdd:cd15049  80 DYVASNASVMNLLLISFDRYFSVTRPLTYRAKRTPKRAILMIALAWVISFVLWAPAILGWQYfvGERTVPDGqCYIQFlD 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 223 HPTwywenlLKICVFIFAFIMPVLIITVCYGLMilrlksvrmlsgSKEKDRNlRRITRMVLVVVAVFIVCWTPIHIYVII 302
Cdd:cd15049 160 DPA------ITFGTAIAAFYLPVLVMTILYWRI------------YRETARE-RKAARTLSAILLAFIITWTPYNILVLV 220
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 84370244 303 KALIT--IPETtfqtvSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15049 221 STFCAkcIPDT-----LWSFGYWLCYINSTINPFCYALCNKTFRKTF 262
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
69-347 1.38e-27

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 110.60  E-value: 1.38e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCKIVISID 147
Cdd:cd15060   1 VVTTILLSVIIAFTIVGNILVILSVFTYRPLRIVQNFFIVSLAVADlAVAIFVLPLNVAYFLLGKWLFGIHLCQMWLTCD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 148 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVM---------FMATTKyrqgsidCT 218
Cdd:cd15060  81 ILCCTASILNLCAIALDRYWAIHDPINYAQKRTLKRVLLMIVVVWALSALISVPPLigwndwpenFTETTP-------CT 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 219 LTFshptwywENLLKICVFIFAFIMPVLIITVCYgLMILRlksvrmlSGSKEkdrnlRRITRMVLVVVAVFIVCWTPIHI 298
Cdd:cd15060 154 LTE-------EKGYVIYSSSGSFFIPLLIMTIVY-VKIFI-------ATSKE-----RRAARTLGIIMGVFVVCWLPFFL 213
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 84370244 299 YVIIKALITIPETTFQTVSwhFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15060 214 MYVILPFCETCSPSAKVVN--FITWLGYVNSALNPVIYTIFNLDFRRAF 260
PHA02834 PHA02834
chemokine receptor-like protein; Provisional
71-366 1.44e-27

chemokine receptor-like protein; Provisional


Pssm-ID: 165177  Cd Length: 323  Bit Score: 111.92  E-value: 1.44e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244   71 IMALYSIVCVVGLFGNFLVMYVIVRYTKMKTaTNIYIFNLALADALATSTLPFQSVNYLmGTWPFGTILCKIVISIDYYN 150
Cdd:PHA02834  31 VIVFYILLFIFGLIGNVLVIAVLIVKRFMFV-VDVYLFNIAMSDLMLVFSFPFIIHNDL-NEWIFGEFMCKLVLGVYFVG 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  151 MFTSIFTLCTMSVDRYIAVCHPVKaLDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWEN 230
Cdd:PHA02834 109 FFSNMFFVTLISIDRYILVVNATK-IKNKSISLSVLLSVAAWVCSVILSMPAMVLYYVDNTDNLKQCIFNDYHENFSWSA 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  231 LLKICVFIFAFIMPVLIITVCYGLMILRLKSVRmlsgskekDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKA-----L 305
Cdd:PHA02834 188 FFNFEINIFGIVIPLIILIYCYSKILYTLKNCK--------NKNKTRSIKIILTVVTFTVVFWVPFNIVLFINSlqsvgL 259
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 84370244  306 ITIPETTFQTV--SWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSTRV 366
Cdd:PHA02834 260 IDIGCYHFKKIvySIDIAELISFVHCCVNPIIYAFVGKNFKKVFKNMFCRTNNIFIRQSSNNV 322
7tmA_LPAR5 cd15154
lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G ...
75-347 1.53e-27

lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 5 (LPAR5) is a G protein-coupled receptor that binds the bioactive lipid lysophosphatidic acid (LPA) and is involved in maintenance of human hair growth. Phylogenetic analysis of the class A GPCRs shows that LAPR5 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(q) and G(12/13) proteins.


Pssm-ID: 320282 [Multi-domain]  Cd Length: 285  Bit Score: 111.01  E-value: 1.53e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  75 YSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTS 154
Cdd:cd15154   7 YSLLFPVGLLLNAVALWVFVRYLRLHSVVSIYMCNLALSDLLFTLSLPLRIYYYANHYWPFGNFLCQFSGSIFQMNMYGS 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 155 IFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFM---ATTKYRQGSID-CTLTFShpTWYWEN 230
Cdd:cd15154  87 CLFLMCINVDRYLAIVHPLRFRHLRRPKVARLLCLAVWALILGGSVPAAIVhssSDCLLHGEKVYrCFESFS--DNDWKG 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 231 LLKICVF--IFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEkdrnlRRITRMVLVVVAVFIVCWTP----IHIYVIIKA 304
Cdd:cd15154 165 LLPLVVLaeILGFLLPLAAVLYCSCRIFVELCRTQEPQQGRR-----RKTVRLLLVNLVIFLICFVPynttLAVYGLLRA 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 84370244 305 -LITIPETTFQTVS--WHFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15154 240 nLVEDTWNIKDTLRkvLSVTVLLASTNCALDPLVYYFSTEGFRNTL 285
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
74-345 1.57e-27

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 111.19  E-value: 1.57e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  74 LYSIVCVVGLFGNFLVMYVIVRyTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMgtWPFGTILCKIVISIDYYNMF 152
Cdd:cd14978   6 VLPVICIFGIIGNILNLVVLTR-KSMRSSTNVYLAALAVSDiLVLLSALPLFLLPYIA--DYSSSFLSYFYAYFLPYIYP 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 153 -------TSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPT 225
Cdd:cd14978  83 lantfqtASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRFFEYEVVECENCNNNSYYYVIPT 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 226 ------WYWENLLKICVFIFAFIMPVLIITVCYGLMILRLK--------SVRMLSGSKEKDRNLRRITRMVLVVVAVFIV 291
Cdd:cd14978 163 llrqneTYLLKYYFWLYAIFVVLLPFILLLILNILLIRALRkskkrrrlLRRRRRLLSRSQRRERRTTIMLIAVVIVFLI 242
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 84370244 292 CWTPihiYVIIKALITIPETTFQTVSWHFCIA----LGYTNSCLNPVLYAFLDENFKR 345
Cdd:cd14978 243 CNLP---AGILNILEAIFGESFLSPIYQLLGDisnlLVVLNSAVNFIIYCLFSSKFRR 297
7tmA_ACKR4_CCR11 cd15176
atypical chemokine receptor 4, member of the class A family of seven-transmembrane G ...
73-344 1.75e-27

atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR4 was first reported to bind several CC chemokines including CCL19, CCL21, and CCL25 and was originally designated CCR11. AKCR4 is unable to couple to G-protein and, instead, it preferentially mediates beta-arrestin dependent processes, such as receptor internalization, after ligand binding. Thus, ACKR4 may act as a scavenger receptor to suppress the effects of proinflammatory chemokines. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320304 [Multi-domain]  Cd Length: 276  Bit Score: 110.60  E-value: 1.75e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  73 ALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGtWPFGTILCKIVISIDYYNMF 152
Cdd:cd15176   5 VFYTIALVVGLAGNSLVVAIYAYYKKLKTKTDVYILNLAVADLLLLFTLPFWAADAVNG-WVLGTAMCKITSALYTMNFS 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 153 TSIFTLCTMSVDRYIAVchpVKALDF-RTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPT-WYWEN 230
Cdd:cd15176  84 CGMQFLACISVDRYVAI---TKATSRqFTGKHCWIVCLCVWLLAILLSIPDLVFSTVRENSDRYRCLPVFPPSLvTSAKA 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 231 LLKICVFIFAFIMPVLIITVCYGLMilrlksVRMLSGSKEKDRnlRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPE 310
Cdd:cd15176 161 TIQILEVLLGFVLPFLVMVFCYSRV------ARALSRTPNVKK--SRALKVLLAVVGVFIVTQLPYNVVKFYRAIDVIYL 232
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 84370244 311 -TTFQTVSWHFCIALGYTNS------CLNPVLYAFLDENFK 344
Cdd:cd15176 233 lITDCSMSKTLDIAIQVTESialfhsCLNPVLYVFMGASFK 273
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
77-347 2.53e-27

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 109.71  E-value: 2.53e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  77 IVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGT-WPFGTILCKIVISIDYYNMFTS 154
Cdd:cd15052   9 LLVIATIGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLvGLLVMPLSILTELFGGvWPLPLVLCLLWVTLDVLFCTAS 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 155 IFTLCTMSVDRYIAVCHPVKALDFRTPRNA--KIVNVcnWILSSAIGLPV----MFMATTKYRQGSidCTLTFSHptwyw 228
Cdd:cd15052  89 IMHLCTISLDRYMAIRYPLRTRRNKSRTTVflKIAIV--WLISIGISSPIpvlgIIDTTNVLNNGT--CVLFNPN----- 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 229 enlLKICVFIFAFIMPVLIITVCYGLmilrlkSVRMLsgskekdRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKAL--- 305
Cdd:cd15052 160 ---FVIYGSIVAFFIPLLIMVVTYAL------TIRLL-------SNEQKASKVLGIVFAVFVICWCPFFITNILTGLcee 223
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 84370244 306 --ITIPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15052 224 cnCRISPWLLSVFVW-----LGYVSSTINPIIYTIFNKTFRRAF 262
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
74-347 3.75e-27

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 110.34  E-value: 3.75e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  74 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALA-TSTLPFQsVNYLMGTWP--FGTILCKIVISIDYYN 150
Cdd:cd15357   6 VYAVIFVVGVIGNLLVCLVILKHQNMKTPTNYYLFSLAVSDLLVlLFGMPLE-VYEMWSNYPflFGPVGCYFKTALFETV 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 151 MFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLP--------VMFMATTKYRQGSIDCTLTfs 222
Cdd:cd15357  85 CFASILSVTTVSVERYVAILHPFRAKLNSTRERALKIIVVLWVLSVLFSIPntsihgikLQYFPNGTLIPDSATCTVV-- 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 223 HPTWYWENLLKICVFIFaFIMPVLIITVCYGLMILRLKSVRMLSgSKEKDRNLRR-----ITRMVLVVVAVFIVCWTPIH 297
Cdd:cd15357 163 KPLWIYNLIIQITSLLF-YVLPMGVISVLYYLMGLKLRGDKSLE-ADEMNVNIQRpsrksVTKMLFVLVLVFAICWAPFH 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 84370244 298 IYVIIKALITIPETTFQTVSWHFCIALG---YTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15357 241 VDRLFFSFVVEWTEPLANVFNLIHVVSGvffYLSSAVNPIIYNLLSRRFRTAF 293
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
71-346 5.84e-27

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 109.07  E-value: 5.84e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  71 IMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQS-VNYLMGTWPFGTILCKIVISIDYY 149
Cdd:cd15012   2 FIILYTLVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNlSIYLIPSWPFGEVLCRMYQFVHSL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 150 NMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWE 229
Cdd:cd15012  82 SYTASIGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWLTSAVYNTPYFVFSQTVEILVTQDGQEEEICVLDREM 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 230 NLLKI---CVFIFAFIMPVLIITVCYGLMilrlkSVRMLSGSKEKDRnlRRITRMVLVVVAVFIVCWTPIHIYVIIKALI 306
Cdd:cd15012 162 FNSKLydtINFIVWYLIPLLIMTVLYSKI-----SIVLWKSSSIEAR--RKVVRLLVAVVVSFALCNLPYHARKMWQYWS 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 84370244 307 --TIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRC 346
Cdd:cd15012 235 epYRCDSNWNALLTPLTFLVLYFNSAVNPLLYAFLSKRFRQS 276
7tmA_NPY4R cd15397
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G ...
69-345 8.44e-27

neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320519 [Multi-domain]  Cd Length: 293  Bit Score: 109.06  E-value: 8.44e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISID 147
Cdd:cd15397   1 VFLVVSYSLVMAVGLLGNICLICVIARQKEKTNVTNILIANLSFSDILvCLVCLPFTVVYTLMDYWIFGEVLCKMTPFIQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 148 YYNMFTSIFTLCTMSVDRYIAVCHPV--KAldfrTPRNAKIVNVCNWILSSAIGLPvmFMATT-----KYRQGSIDCTLT 220
Cdd:cd15397  81 CMSVTVSILSLVLIALERHQLIINPTgwKP----SVSQAYLAVVVIWMLACFISLP--FLAFHiltdePYKNLSHFFAPL 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 221 FSH----PTWYWENLLKI---CVFIFAFIMPVLIITVCYGLMILRL-KSVRMLSGSKEKDR---NLRRITRMVLVVVAVF 289
Cdd:cd15397 155 ADKavctESWPSEHHKLAyttWLLLFQYCLPLLFILVCYLRIYLRLrRRKDMLERRGEYNRragHSKRINVMLVSLVAAF 234
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 290 IVCWTPIHIYVIIkalitipettfqtVSWH--------------FCIALGYTNSCLNPVLYAFLDENFKR 345
Cdd:cd15397 235 ALCWLPLNVFNAI-------------ADWNheaiphcqhnlifsLCHLAAMASTCVNPIIYGFLNSNFKK 291
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
70-347 1.74e-26

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 108.47  E-value: 1.74e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  70 TIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST-LPFQSVNYLMGTWPFGTILCKIVISIDY 148
Cdd:cd15123   2 AIYVTYAVIISVGILGNAILIKVFFKIKSMQTVPNIFITSLAFGDLLLLLTcVPVDATRYIADTWLFGRIGCKLLSFIQL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 149 YNMFTSIFTLCTMSVDRYIAVCHPVKaldfRTPRNAKIVN----VCNWILSSAIGLP-VMFMATTKYRQGSIDCTLTFSH 223
Cdd:cd15123  82 TSVGVSVFTLTVLSADRYRAIVKPLE----LQTSDAVLKTcckaGCVWIVSMLFAIPeAVFSDLYSFRDPEKNTTFEACA 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 224 PTWYWENLLK-----ICVFIFaFIMPVLIITVCYGLMILRL-KSVRML-----SGSKEKDRNLRRITRMVLVVVAVFIVC 292
Cdd:cd15123 158 PYPVSEKILQeihslLCFLVF-YIIPLSIISVYYFLIARTLyKSTFNMpaeehSHARKQIESRKRVAKTVLVLVALFAFC 236
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 84370244 293 WTPIHIYVIIKALI---TIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15123 237 WLPNHILYLYRSFTyhtSVDSSAFHLIATIFSRVLAFSNSCVNPFALYWLSKSFRQHF 294
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
75-347 1.98e-26

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 108.09  E-value: 1.98e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  75 YSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAlatSTLPFQS-VNY---LMGTWPFGTILCKIVISIDYYN 150
Cdd:cd16003   7 YGFVVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDA---SMAAFNTlINFiyaLHSEWYFGEAYCRFHNFFPITS 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 151 MFTSIFTLCTMSVDRYIAVCHPVKaldfrtPR----NAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFshPTW 226
Cdd:cd16003  84 VFASIYSMTAIAVDRYMAIIDPLK------PRlsatATKVVIGSIWILAFLLAFPQCLYSKTKVMPGRTLCFVAW--PGG 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 227 YWENLL-KICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKD----RNLRRITRMVLVVVAVFIVCWTPIHIYVI 301
Cdd:cd16003 156 PDQHFTyHIIVIVLVYCLPLLVMGITYTIVGITLWGGEIPGDTSDKYheqlRAKRKVVKMMIIVVLTFAICWLPYHIYFI 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 84370244 302 IKAL-ITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd16003 236 VTGLyQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGF 282
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
67-345 2.31e-26

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 107.68  E-value: 2.31e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  67 TAITIMALYSIVcvVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCKIVIS 145
Cdd:cd15402   1 TALACILIFTIV--VDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADlVVAIYPYPLVLTSIFHNGWNLGYLHCQISGF 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 146 IDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPT 225
Cdd:cd15402  79 LMGLSVIGSIFNITGIAINRYCYICHSLKYDKLYSDKNSLCYVLLIWVLTVAAIVPNLFVGSLQYDPRIYSCTFAQSVSS 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 226 WYwenllKICVFIFAFIMPVLIITVCY----GLMILRLKSVRMLSGSKEKDRNLRRITRMvLVVVAVFIVCWTPIHIyvI 301
Cdd:cd15402 159 AY-----TIAVVFFHFILPIIIVTFCYlriwILVIQVRRRVKPDNKPKLKPHDFRNFVTM-FVVFVLFAVCWAPLNF--I 230
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 84370244 302 IKALITIPETTFQTV-SWHFCIA--LGYTNSCLNPVLYAFLDENFKR 345
Cdd:cd15402 231 GLAVAVDPETIVPRIpEWLFVASyyMAYFNSCLNAIIYGLLNQNFRR 277
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
69-347 2.66e-26

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 107.89  E-value: 2.66e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST-LPFQSVNYLMGTWPFGTILCKIVISID 147
Cdd:cd14977   1 YVIMSLSLVIFAVGIIGNLMVLCIVCTNYYMRSVPNILIASLALGDLLLLLLcVPLNAYNLLTKDWLFGDVMCKLVPFIQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 148 YYNMFTSIFTLCTMSVDRYIAVC--HPVKALDFRTPRNAKIVNVcnWILSSAIGLPVMFMATTK----YRQGSID-CTLT 220
Cdd:cd14977  81 VTSLGVTVFSLCALSIDRYRAAVnsMPMQTIGACLSTCVKLAVI--WVGSVLLAVPEAVLSTVAressLDNSSLTvCIMK 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 221 FS------HPTW--YWenllkicVFIFAFIMPVLIITVCYGLM--ILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFI 290
Cdd:cd14977 159 PStpfaetYPKArsWW-------LFGCYFCLPLAFTAVCYLLMarTLIRAAKEYTRGTKKHMKQRRQLAKTVLCLVLVFA 231
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 84370244 291 VCWTPIHIYVIIKAL----ITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd14977 232 FCWLPEHISNILRATlyneVLIDTRSTLDILDLIGQFLSFFNSCVNPIALYLLSEPFRRAF 292
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
72-338 2.71e-26

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 107.60  E-value: 2.71e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  72 MALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNM 151
Cdd:cd15121   4 IAILSLAFILGFPGNLFVVWSVLCRMKKRSVTCILVLNLALADAAVLLTAPFFLHFLSGGGWEFGSVVCKLCHYVCGVSM 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 152 FTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIdcTLTF-SHPTWYWEN 230
Cdd:cd15121  84 YASIFLITLMSMDRCLAVAKPFLSQKMRTKRSVRALLLAIWIVAFLLSLPMPFYRTVLKKNINM--KLCIpYHPSVGHEA 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 231 LLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMlsgskekdRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKA------ 304
Cdd:cd15121 162 FQYLFETITGFLLPFTAIVTCYSTIGRRLRSARF--------RRKRRTNRLVVLIIATFALFWLPYHVVNLIQVagalqn 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 84370244 305 ------LITIPETTFQTVswhfcIALGYTNSCLNPVLYAF 338
Cdd:cd15121 234 qagnasVLKAAKLARPNV-----TALAFLSSSVNPVLYAF 268
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
71-347 2.80e-26

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 107.82  E-value: 2.80e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  71 IMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISIDYY 149
Cdd:cd15065   2 IGIFLSLIIVLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLvALLVMTFAVVNDLLGYWLFGETFCNIWISFDVM 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 150 NMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIG-LPVMFMATTKYRQGSIDCTLTFS-HPTWY 227
Cdd:cd15065  82 CSTASILNLCAISLDRYIHIKKPLKYERWMTTRRALVVIASVWILSALISfLPIHLGWHRLSQDEIKGLNHASNpKPSCA 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 228 WENLLKICVF--IFAFIMPVLIITVCYGLMIL-------RLKSVRMLSGSKEKDRNLRRITRMVLVVVA----------- 287
Cdd:cd15065 162 LDLNPTYAVVssLISFYIPCLVMLLIYSRLYLyarkhvvNIKSQKLPSESGSKFQVPSLSSKHNNQGVSdhkaavtlgii 241
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 84370244 288 --VFIVCWTPIHIYVIIKAL--ITIPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15065 242 mgVFLICWLPFFIINIIAAFckTCIPPKCFKILTW-----LGYFNSCLNPIIYSIFNSEFRRAF 300
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
69-347 4.32e-26

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 107.39  E-value: 4.32e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISID 147
Cdd:cd15048   1 IVLAVLISVLILVTVIGNLLVILAFIKDKKLRTVSNFFLLNLAVADFLvGLVSMPFYIPYTLTGKWPFGKVFCKAWLVVD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 148 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFmATTKYRQGSI----DCTLTFsH 223
Cdd:cd15048  81 YTLCTASALTIVLISLDRYLSVTKAVKYRAKQTKRRTVLLMALVWILAFLLYGPAII-GWDLWTGYSIvptgDCEVEF-F 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 224 PTWYWenllKICVFIFAFIMPVLIITVCYGLMIL---------RLKSVRMLSGSKEKDRNL-----------RRITRMVL 283
Cdd:cd15048 159 DHFYF----TFITSVLEFFIPFISVSFFNLLIYLnirkrsrrrPLRSVPILPASQNPSRARsqreqvklrrdRKAAKSLA 234
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 84370244 284 VVVAVFIVCWTPIHIYVIIKALITipETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15048 235 ILVLVFLICWAPYTILTIIRSFCS--GSCVDSYLYEFTFWLLWTNSAINPFLYAACHPRFRKAF 296
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
74-347 4.60e-26

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 106.88  E-value: 4.60e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  74 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMF 152
Cdd:cd15978   6 LYSLIFLLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDlMLCLFCMPFTLIPNLLKDFIFGSAVCKTATYFMGISVS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 153 TSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMAT----TKYRQGSID-CTLTF----SH 223
Cdd:cd15978  86 VSTFNLVAISLERYSAICKPLKSRVWQTKSHALKVIAATWCLSFTIMLPYPIYSNlvpfTRINNSTGNmCRLLWpndvTQ 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 224 PTWYwenllkICVFIFAFIMPVLIITVCYGLMILRL-KSVRMLSGSKekdrnlrRITRMVLVVVAVFIVCWTPIHIYVII 302
Cdd:cd15978 166 QSWY------IFLLLILFLIPGIVMMTAYGLISLELyRGIKFLMAKK-------RVIRMLIVIVILFFLCWTPIFSANAW 232
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 84370244 303 KALITI-PETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15978 233 RAFDTRsADRLLSGAPISFIHLLSYTSACVNPIIYCFMNKRFRMGF 278
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
69-347 4.65e-26

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 106.42  E-value: 4.65e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST-LPFQSVNYLMGTWPFGTILCKIVISID 147
Cdd:cd15062   1 IVVGVALGAFILFAIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTvLPFSATLEVLGYWAFGRIFCDVWAAVD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 148 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTfshptwy 227
Cdd:cd15062  81 VLCCTASIMSLCVISVDRYIGVRYPLNYPTIVTARRATVALLIVWVLSLVISIGPLLGWKEPAPADEQACGVN------- 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 228 WENLLKICVFIFAFIMPVLIITVCYGLMIlrlksVRMLSGSKEKdrnlrRITRMVLVVVAVFIVCWTPIHIYVIIKAL-- 305
Cdd:cd15062 154 EEPGYVLFSSLGSFYLPLAIILVMYCRVY-----VVAFKFSREK-----KAAKTLGIVVGAFVLCWFPFFVVLPLGSLfs 223
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 84370244 306 -ITIPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15062 224 tLKPPEPVFKVVFW-----LGYFNSCLNPIIYPCSSREFKRAF 261
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
71-347 4.81e-26

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 107.23  E-value: 4.81e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  71 IMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST-LPFQSV----NYlmgTWPFGTILCKIVIS 145
Cdd:cd15133   3 VCLTYLLIFVVGVVGNVLTCLVIARHKAMRTPTNYYLFSLAVSDLLVLLLgMPLELYelwqNY---PFLLGSGGCYFKTF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 146 IDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSH-- 223
Cdd:cd15133  80 LFETVCLASILNVTALSVERYIAVVHPLAARTCSTRPRVTRVLGCVWGVSMLCALPNTSLHGIKFLGSGVPASAQCTVrk 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 224 PTWYWENLLKICVFIFaFIMPVLIITVCYGLMILRLKSVRMLS-------------GSKEKDRNLRRITRMVLVVVAVFI 290
Cdd:cd15133 160 PQAIYNMIPQHTGHLF-FVLPMAVISVLYLLMALRLARERGLDatgagskigtrtgQLLQHPRTRAQVTKMLFILVVVFA 238
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 291 VCWTPIHIYVIIKALITIPETTFQTVSWHFCIALG---YTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15133 239 ICWAPFHIDRLMWSFISDWTDNLHEVFQYVHIISGvffYLSSAVNPILYNLMSTRFREMF 298
7tmA_P2Y10 cd15153
P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled ...
73-344 5.05e-26

P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y10 receptor is a G-protein coupled receptor that is activated by both sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA). Phylogenetic analysis of the class A GPCRs shows that P2Y10 is grouped into the cluster comprising nucleotide and lipid receptors. Although the mouse P2Y10 was found to be expressed in brain, lung, reproductive organs, and skeletal muscle, the physiological function of this receptor is not yet known. S1P and LPA are bioactive lipid molecules that induce a variety of cellular responses through G proteins: adhesion, invasion, cell migration and proliferation, among many others.


Pssm-ID: 320281 [Multi-domain]  Cd Length: 283  Bit Score: 106.80  E-value: 5.05e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  73 ALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMF 152
Cdd:cd15153   5 TTYIIIFIPGLLANSAALWVLCRFISKKNKAIIFMINLAVADLAHVLSLPLRIHYYIQHTWPFGRFLCLLCFYLKYLNMY 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 153 TSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCnWILSSAIGLPVMFMATTKYRQGSIDC--TLTFSHPTWYWEN 230
Cdd:cd15153  85 ASICFLTCISIQRCFFLLHPFKARDWKRRYDVGISAAV-WIVVGLACLPFPLLRSKSLSNNNRSCfaDLGMKKLNFGAAI 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 231 LLKICVFIFAFIMPVLIITVCYGLMILRLKSVRM-LSGSKEKDRNLrritRMVLVVVAVFIVCWTPIHI-----YVIIKA 304
Cdd:cd15153 164 AMMTVAELFGFVIPLFIIAWCTWKTENSLRQRNKqQQSTSEKQKAL----RMVRMCAAVFFICFAPYHInflfyLMVSES 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 84370244 305 LITIPETTFQTVSWH-FCIALGYTNSCLNPVLYAFLDENFK 344
Cdd:cd15153 240 IITNCEVSQVILQFHpISLCLASLNCCLDPILYYFMTSEFQ 280
7tmA_CX3CR1 cd15186
CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G ...
74-345 6.35e-26

CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CX3CR1 is an inflammatory receptor specific for CX3CL1 (also known as fractalkine in human), which is involved in the adhesion and migration of leukocytes. The CX3C chemokine subfamily is only represented by CX3CL1, which exists in both soluble and membrane-anchored forms. Membrane-anchored form promotes strong adhesion of receptor-bearing leukocytes to CX3CL1-expressing endothelial cells. On the other hand, soluble CX3CL1, which is released by the proteolytic cleavage of membrane-anchored CX3CL1, is a potent chemoattractant for CX3CR1-expressing T cells and monocytes. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 320314 [Multi-domain]  Cd Length: 273  Bit Score: 106.07  E-value: 6.35e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  74 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSvNYLMGTWPFGTILCKIVISIDYYNMFT 153
Cdd:cd15186   6 FYSLVFAFGLVGNLLVVLALTNSGKSKSITDIYLLNLALSDLLFVATLPFWT-HYLINEWGLHNAMCKLTTAFFFIGFFG 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 154 SIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPvMFMATtkyRQGSIDCTLTFSHPTW-YWENLL 232
Cdd:cd15186  85 GIFFITVISIDRYLAIVLAANSMNNRTVQHGVTISLGVWAAAILVAVP-QFMFT---KMKENECLGDYPEVLQeIWPVLR 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 233 KICVFIFAFIMPVLIITVCYGLMILRLKSVrmlsgskeKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKAL------I 306
Cdd:cd15186 161 NVELNFLGFLLPLLIMSYCYFRIIQTLFSC--------KNHKKARAIKLILLVVIVFFLFWTPYNVMIFLETLklydffP 232
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 84370244 307 TIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKR 345
Cdd:cd15186 233 SCDMKKDLRLALSVTETIAFSHCCLNPLIYAFAGEKFRR 271
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
75-347 1.13e-25

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 105.72  E-value: 1.13e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  75 YSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAlatSTLPFQSV-NYLMGT---WPFGTILCKIVISIDYYN 150
Cdd:cd16002   7 YSVIVVVSVVGNIIVMWIILAHKRMRTVTNYFLVNLAFAEA---SMSAFNTViNFTYAIhneWYYGLEYCKFHNFFPIAA 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 151 MFTSIFTLCTMSVDRYIAVCHPVKAldfRTPRNAKIVNVCN-WILSSAIGLPVMFMATTKYRQGSIDCTLTF-SHPTWYW 228
Cdd:cd16002  84 VFASIYSMTAIALDRYMAIIHPLQP---RLSATATKVVICViWVLAFLLAFPQGYYSDTEEMPGRVVCYVEWpEHEERKY 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 229 ENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSK----EKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKA 304
Cdd:cd16002 161 ETVYHVCVTVLIYFLPLLVIGCAYTVVGITLWASEIPGDSSdryhEQVSAKRKVVKMMIVVVCTFAICWLPYHIYFLLQY 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 84370244 305 LitIPETTFQTVSWHFCIA---LGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd16002 241 F--HPELYEQKFIQQVYLAimwLAMSSTMYNPIIYCCLNDRFRVGF 284
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
69-347 1.13e-25

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 106.03  E-value: 1.13e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISID 147
Cdd:cd15056   1 VVLSTFLSLVILLTILGNLLVIVAVCTDRQLRKKTNYFVVSLAVADLLvAVLVMPFGAIELVNNRWIYGETFCLVRTSLD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 148 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCnWILSSAIG-LPVM---------FMATTKYRQGSIDC 217
Cdd:cd15056  81 VLLTTASIMHLCCIALDRYYAICCQPLVYKMTPLRVAVMLGGC-WVIPTFISfLPIMqgwnhigieDLIAFNCASGSTSC 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 218 TLTFSHPtwywenLLKICVFIfAFIMPVLIITVCYGLMIL----RLKSVRML--SGSKEKDRNLRRITRMVLVVVAVFI- 290
Cdd:cd15056 160 VFMVNKP------FAIICSTV-AFYIPALLMVLAYYRIYVaareQAHQIRSLqrAGSSNHEADQHRNSRMRTETKAAKTl 232
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 84370244 291 --------VCWTPIHIYVIIKALItipETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15056 233 giimgcfcVCWAPFFVTNIVDPFI---GYRVPYLLWTAFLWLGYINSGLNPFLYAFFNKSFRRAF 294
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
80-344 1.28e-25

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 105.74  E-value: 1.28e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  80 VVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVN-YLMGTWPFGTILCKIVISIDYYNMFTSIFTL 158
Cdd:cd15131  12 VVGVTGNLMTMLVVSKYRDMRTTTNLYLSSMAFSDLLIFLCMPLDLYRlWQYRPWNFGDLLCKLFQFVSESCTYSTILNI 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 159 CTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYW--ENLLKICV 236
Cdd:cd15131  92 TALSVERYFAICFPLRAKVVVTKRRVKLVILVLWAVSFLSAGPIFVLVGVEHENGTNPIDTNECKATEYAvrSGLLTIMV 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 237 FIFA--FIMPVLIITVCYGLM---ILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPET 311
Cdd:cd15131 172 WVSSvfFFLPVFCLTVLYSLIgrkLWRRRRENIGPNASHRDKNNRQTVKMLAVVVFAFVLCWLPFHVGRYLFSKSFEAGS 251
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 84370244 312 TFQTVSWHFC----IALGYTNSCLNPVLYAFLDENFK 344
Cdd:cd15131 252 LEIALISQYCnlvsFVLFYLSAAINPILYNIMSKKYR 288
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
69-347 1.34e-25

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 104.95  E-value: 1.34e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISID 147
Cdd:cd15324   1 ALIVLVVVVIILVTIVGNVLVVVAVFTSRALRAPQNLFLVSLASADILvATLVIPFSLANEVMGYWYFGSTWCAFYLALD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 148 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQgsidCTLTfsHPTWY 227
Cdd:cd15324  81 VLFCTSSIVHLCAISLDRYWSVTKAVSYNLKRTPKRIKRMIAVVWVISAVISFPPLLMTKHDEWE----CLLN--DETWY 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 228 wenLLKICvfIFAFIMPVLIITVCYgLMILRLKSVRMlsgskekdrnlRRITRMVLVVVAVFIVCWTPI----HIYVIIK 303
Cdd:cd15324 155 ---ILSSC--TVSFFAPGLIMILVY-CKIYRVAKMRE-----------KRFTFVLAVVMGVFVLCWFPFfftySLHAVCR 217
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 84370244 304 ALITIPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15324 218 KRCGIPDALFNLFFW-----IGYCNSSVNPIIYTIFNRDFRKAF 256
7tmA_GPR68_OGR1 cd15367
G protein-coupled receptor 68, member of the class A family of seven-transmembrane G ...
75-347 1.58e-25

G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors; The ovarian cancer G-protein receptor 1 (OGR1, also known as GPR68) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), and the G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Knock-out mice studies have suggested that OGR1 plays a role in the regulation of insulin secretion and glucose metabolism. OGR1 couples to G(q/11) proteins and activates phospholipase C and Ca2+ signaling pathways.


Pssm-ID: 320489 [Multi-domain]  Cd Length: 276  Bit Score: 105.23  E-value: 1.58e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  75 YSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMG-TWPFGTILCKIVISIDYYNMFT 153
Cdd:cd15367   7 YILVLVVGLPANCLSLYYGYLQIKAKNELGIYLCNLTVADLLYIFSLPFWLQYVLQHdNWTYSELLCKICGILLYENIYI 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 154 SIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWIlsSAIGLPVMFMATTKYRQGSIDCTLTFSH-PTWYWENLL 232
Cdd:cd15367  87 SIGFLCCISVDRYLAVVHPFRFHAFRTMKAATLVSTVIWL--KELMTCVFFFLHGEISKDKENHSVCFEHyPIKAWEHNI 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 233 KICVFIFAFIMPVLIITVCYGLMilrLKSVRMLSGSKEKDRNlrRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETT 312
Cdd:cd15367 165 NYYRFYAGFLFPIFLLSFSYCRI---LRAVRKSHGTQKSQKI--QIKRLVLSTVVIFLVCFGPYHILLLVRSVFERDCNF 239
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 84370244 313 FQTV--SWHFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15367 240 AEGIfnYYHFSLLLTSFNCVADPVLYCFASESTYHDF 276
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
76-347 1.73e-25

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 104.68  E-value: 1.73e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  76 SIVCvvGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATS-TLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTS 154
Cdd:cd15330  10 LILC--AIFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVlVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 155 IFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMF-MATTKYRQGSIDCTLTFSHPTWYWENLlk 233
Cdd:cd15330  88 ILHLCAIALDRYWAITDPIDYVNKRTPRRAAVLISLTWLIGFSISIPPMLgWRTPEDRSDPDACTISKDPGYTIYSTF-- 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 234 icvfiFAFIMPVLIITVCYGlmilrlksvRMLSGSKEKdrnlRRITRMVLVVVAVFIVCWTPIHIYVII----KALITIP 309
Cdd:cd15330 166 -----GAFYIPLILMLVLYG---------RIFKAAARE----RKTVKTLGIIMGTFILCWLPFFIVALVlpfcESTCHMP 227
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 84370244 310 ETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15330 228 ELLGAIINW-----LGYSNSLLNPIIYAYFNKDFQSAF 260
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
69-347 3.03e-25

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 104.11  E-value: 3.03e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVgLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISID 147
Cdd:cd15063   2 ISLLVLTFLNVLV-VLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLvGTLVLPFSAVNEVLDVWIFGHTWCQIWLAVD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 148 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTkyRQGSIDCTLTFSHPTWY 227
Cdd:cd15063  81 VWMCTASILNLCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVLSFVICFPPLVGWND--GKDGIMDYSGSSSLPCT 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 228 WENLLKICVFIFA----FIMPVLIITVCYGlmilrlKSVRMLSGSKEKDRNLRRITRMvlvvvavFIVCWTPIHIYVIIK 303
Cdd:cd15063 159 CELTNGRGYVIYSalgsFYIPMLVMLFFYF------RIYRAARMETKAAKTVAIIVGC-------FIFCWLPFFTVYLVR 225
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 84370244 304 ALIT--IPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15063 226 AFCEdcIPPLLFSVFFW-----LGYCNSALNPCIYALFSRDFRFAF 266
7tmA_LTB4R2 cd15122
leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of ...
66-338 3.97e-25

leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320250 [Multi-domain]  Cd Length: 281  Bit Score: 104.12  E-value: 3.97e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  66 VTAITIMALYSIVcvvGLFGNFLVMYVIV--RYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIV 143
Cdd:cd15122   1 ATGTIFLLLAALL---GLPGNGFIIWSILwkMKARGRSVTCILILNLAVADGAVLLLTPFFITFLTRKTWPFGQAVCKAV 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 144 ISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSH 223
Cdd:cd15122  78 YYLCCLSMYASIFIIGLMSLDRCLAVTRPYLAQSLRKKALVRKILLAIWLLALLLALPAFVYRHVWKDEGMNDRICEPCH 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 224 PTwyweNLLKICVFIF----AFIMPVLIITVCYGLMILRLKSVRMLSGSkekdrnlrRITRMVLVVVAVFIVCWTPIHIY 299
Cdd:cd15122 158 AS----RGHAIFHYTFetlvAFVLPFGVILFSYSVILVRLKGARFRRRA--------RVEKLIAAIVVAFALLWVPYHVV 225
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 84370244 300 VIIKALITIPETTFQTVSWHF-------CIALGYTNSCLNPVLYAF 338
Cdd:cd15122 226 NLLQVVANLAPGEVLEKLGGAakaaragATALAFFSSSVNPLLYVF 271
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
76-347 4.70e-25

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 103.45  E-value: 4.70e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  76 SIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTS 154
Cdd:cd15327   8 AIFILMAIVGNILVILSVACNRHLQTVTNYFIVNLAIADLLlSTTVLPFSATLEVLGFWAFGRVFCDIWAAVDVLCCTAS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 155 IFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGL-PVMFMATTKYRQGSIdCTLTfSHPTWywenllK 233
Cdd:cd15327  88 ILSLCVISVDRYVGVKHSLKYPTIMTERKAGVILVLLWVSSMVISIgPLLGWKEPPPPDESI-CSIT-EEPGY------A 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 234 ICVFIFAFIMPVLIITVCYglmiLRLKSVrMLSGSKEKdrnlrRITRMVLVVVAVFIVCWTPIHIYVIIKAL---ITIPE 310
Cdd:cd15327 160 LFSSLFSFYLPLMVILVMY----FRVYVV-ALKFSREK-----KAAKTLAIVVGVFILCWFPFFFVLPLGSFfpaLKPSE 229
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 84370244 311 TTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15327 230 MVFKVIFW-----LGYFNSCVNPIIYPCSSKEFKRAF 261
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
76-344 5.04e-25

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 104.38  E-value: 5.04e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  76 SIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTS 154
Cdd:cd14986   8 GVLFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADlVVAFFTVLTQIIWEATGEWVAGDVLCRIVKYLQVVGLFAS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 155 IFTLCTMSVDRYIAVCHPVKALDFRtpRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSI-DCTLTFSHPtWYWEnLLK 233
Cdd:cd14986  88 TYILVSMSLDRYQAIVKPMSSLKPR--KRARLMIVVAWVLSFLFSIPQLVIFVERELGDGVhQCWSSFYTP-WQRK-VYI 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 234 ICVFIFAFIMPVLIITVCYGLMI------LRLKSVRMLSGSKEKDRNLR--------------RITRMVLVVVAVFIVCW 293
Cdd:cd14986 164 TWLATYVFVIPLIILSYCYGRILrtiwirSRQKTDRPIAPTAMSCRSVScvssrvslisrakiKTIKMTLVIILAFILCW 243
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 84370244 294 TP---IHIYVIIKALITIPETTFQTVSwhfciALGYTNSCLNPVLYAFLDENFK 344
Cdd:cd14986 244 TPyfiVQLLDVYAGMQQLENDAYVVSE-----TLASLNSALNPLIYGFFSSHLS 292
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
72-347 6.56e-25

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 104.02  E-value: 6.56e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  72 MALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSV-NYLMgTWPFGTILCKIVISIDYY 149
Cdd:cd15195   4 VLVTWVLFVISAAGNLTVLIQLFRRRRAKSHIQILIMHLALADlMVTFFNMPMDAVwNYTV-EWLAGDLMCRVMMFLKQF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 150 NMFTSIFTLCTMSVDRYIAVCHPVKALDFRtpRNAKIVNVCNWILSSAIGLP--VMFMATTK-YRQGSIDCTLTFSHPTW 226
Cdd:cd15195  83 GMYLSSFMLVVIALDRVFAILSPLSANQAR--KRVKIMLTVAWVLSALCSIPqsFIFSVLRKmPEQPGFHQCVDFGSAPT 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 227 YW-ENLLKICVFIFAFIMPVLIITVCYGLMIL----RLKSVRMLSGSKEKDRNLRRITR-------MVLVVVAVFIVCWT 294
Cdd:cd15195 161 KKqERLYYFFTMILSFVIPLIITVTCYLLILFeiskMAKRARDTPISNRRRSRTNSLERarmrtlrMTALIVLTFIVCWG 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 84370244 295 PIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15195 241 PYYVLGLWYWFDKESIKNLPPALSHIMFLLGYLNPCLHPIIYGVFMKEIRNWI 293
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
73-349 9.24e-25

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 103.11  E-value: 9.24e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  73 ALYSIVCVVG-LFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYN 150
Cdd:cd15307   4 ALLALVLVLGtAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMvAVLVMPLGILTLVKGHFPLSSEHCLTWICLDVLF 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 151 MFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPtwywen 230
Cdd:cd15307  84 CTASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSLPLSLMYSKDHASVLVNGTCQIPDP------ 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 231 LLKICVFIFAFIMPVLIITVCYGLmilrlkSVRMLSGSKEKD-RNLR---RITRMVLVVVAVFIVCWTPihiYVIIKALI 306
Cdd:cd15307 158 VYKLVGSIVCFYIPLGVMLLTYCL------TVRLLARQRSRHgRIIRleqKATKVLGVVFFTFVILWSP---FFVLNLLP 228
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 84370244 307 T--------IPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCFRE 349
Cdd:cd15307 229 TvcaeceerISHWVFDVVTW-----LGYASSMVNPIFYTIFNKVFRQAFKK 274
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
76-345 1.17e-24

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 103.17  E-value: 1.17e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  76 SIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL--ATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFT 153
Cdd:cd15337   8 AIVGILGVIGNLLVIYLFSKTKSLRTPSNMFIINLAISDFGfsAVNGFPLKTISSFNKKWIWGKVACELYGFAGGIFGFM 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 154 SIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVmFMATTKYRQGSIDCTLTFSHPTWYWENLLK 233
Cdd:cd15337  88 SITTLAAISIDRYLVIAKPLEAMKKMTFKRAFIMIIIIWLWSLLWSIPP-FFGWGRYVPEGFQTSCTFDYLSRDLNNRLF 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 234 I-CVFIFAFIMPVLIITVCYG--LMILRLKSVRML----------SGSKEKDRNLR-RITRMVLVVVAVFIVCWTPihiY 299
Cdd:cd15337 167 IlGLFIFGFLCPLLIIIFCYVniIRAVRNHEKEMTqtaksgmgkdTEKNDARKKAEiRIAKVAIILISLFLLSWTP---Y 243
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 84370244 300 VIIkALITI--PETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKR 345
Cdd:cd15337 244 AVV-ALLGQfgPAYWITPYVSELPVMFAKASAIYNPIIYALSHPKFRA 290
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
77-345 1.22e-24

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 102.93  E-value: 1.22e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  77 IVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSI 155
Cdd:cd15209   9 VTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVvAIYPYPLILHAIFHNGWTLGQLHCQASGFIMGLSVIGSI 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 156 FTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYwenllKIC 235
Cdd:cd15209  89 FNITAIAINRYCYICHSLQYDRLYSLRNTCCYLCLTWLLTVLAVLPNFFIGSLQYDPRIYSCTFAQTVSTVY-----TIT 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 236 VFIFAFIMPVLIITVCY----GLMILRLKSVRMLSGSKEKDRNLRRITRMvLVVVAVFIVCWTPIHIYVIIKAlITIPET 311
Cdd:cd15209 164 VVVIHFLLPLLIVSFCYlriwVLVLQVRQRVKPDQRPKLKPADVRNFLTM-FVVFVLFAVCWAPLNFIGLAVA-INPKEM 241
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 84370244 312 TFQTVSWHFCIA--LGYTNSCLNPVLYAFLDENFKR 345
Cdd:cd15209 242 APKIPEWLFVASyfMAYFNSCLNAIIYGLLNQNFRK 277
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
77-347 1.28e-24

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 102.91  E-value: 1.28e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  77 IVCVVG----LFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNM 151
Cdd:cd15317   5 IVLVLAmlitVSGNLVVIISISHFKQLHSPTNMLVLSLATADFLlGLCVMPFSMIRTVETCWYFGDLFCKFHTGLDLLLC 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 152 FTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSI--------DCTLTFSH 223
Cdd:cd15317  85 TTSIFHLCFIAIDRYYAVCDPLRYPSKITVQVAWRFIAIGWLVPGIYTFGLIYTGANDEGLEEYsseiscvgGCQLLFNK 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 224 pTWYWENLLkicvfifAFIMPVLIITVCYG-LMILRLKSVRMLSG------------SKEKDRNLRRITRMVLVVVAVFI 290
Cdd:cd15317 165 -IWVLLDFL-------TFFIPCLIMIGLYAkIFLVARRQARKIQNmedkfrsseensSKASASRERKAAKTLAIVMGIFL 236
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 84370244 291 VCWTPIHIYVIIKALITI--PETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15317 237 FCWLPYFIDTIVDEYSNFitPAIVFDAVIW-----LGYFNSAFNPFIYAFFYPWFRKAF 290
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
69-347 1.67e-24

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 102.92  E-value: 1.67e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALAT------------STLPFQsvnYLMGTWPFG 136
Cdd:cd15358   1 TPVCVTYLLIFVVGAVGNGLTCIVILRHKVMRTPTNYYLFSLAVSDLLVLllgmplelyemwSNYPFL---LGAGGCYFK 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 137 TILCKIVIsidyynmFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPV-----MFMATTKYR 211
Cdd:cd15358  78 TLLFETVC-------FASILNVTALSVERYIAVVHPLKAKYVVTRTHAKRVIGAVWVVSILCSIPNtslhgIFQLTVPCR 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 212 Q---GSIDCTLTfsHPTWYWENLLKICVFIFaFIMPVLIITVCYGLMILRLKSVRMLS-----GSKE-----------KD 272
Cdd:cd15358 151 GpvpDSATCMLV--KPRWMYNLIIQITTLLF-FFLPMGTISVLYLLIGLQLKREKMLLvleakGSKAgdsyqhrriqqEK 227
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 84370244 273 RNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALG---YTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15358 228 RRRRQVTKMLFVLVVVFGICWAPFHTDRLMWSFISQWTGELHLAFQYVHIISGvffYLSSAANPVLYNLMSTRFREMF 305
7tmA_P2Y-like cd15922
P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G ...
71-347 1.83e-24

P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y-like proteins are an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320588 [Multi-domain]  Cd Length: 284  Bit Score: 102.48  E-value: 1.83e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  71 IMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMG-TWPFGTILCKIVISIDYY 149
Cdd:cd15922   3 IPVFLSLVFLGGFLLNSFSLWIFWFRIKQWSSGTILQFNLALSDAIITPAAPLLIAYFSLGsHWPFGQFLCQLKVFLLST 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 150 NMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDC------TLTFSH 223
Cdd:cd15922  83 HMYGSIYFLMLISIHRYVTVVHYNWKSLWKKKSFMKKLCLGVWLLLFVQGLPFFFVLKTSVIDGKTKClsihqsELSLLY 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 224 PTWYWenllkiCVFIFAFIMPVLIITVCYGLM---ILRLKSvRMLSGSKEKDRNLRRITrmvlVVVAVFIVCWTPIHIY- 299
Cdd:cd15922 163 FVWNF------VLLILGFLLPFGVSLTCYALLgasIAKMNS-NNARGRAMKAKSLQMIG----ISLVIFIICFVPLHVTr 231
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 84370244 300 ---VIIKALITIPETTFQTV--SWHFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15922 232 tvgVVVKLFYPESCTLLHKVevAYYISWVLTGVNCCLDPLLYCFASEKFRKSF 284
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
79-344 1.86e-24

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 102.14  E-value: 1.86e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  79 CVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMG-TWPFGTILCKIVISIDYYNMFTSIFT 157
Cdd:cd14991  11 FVLGLPGNVVALWIFCFHSRTWKANTVYLFNLVLADFLLLICLPFRIDYYLRGeHWIFGEAWCRVNLFMLSVNRSASIAF 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 158 LCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVF 237
Cdd:cd14991  91 LTAVALDRYFKVVHPHHRVNRMSVKAAAGVAGLLWALVLLLTLPLLLSTLLTVNSNKSSCHSFSSYTKPSLSIRWHNALF 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 238 IFAFIMPVLIITVCyglmILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIY----VIIKALITIPETTF 313
Cdd:cd14991 171 LLEFFLPLGLIVFC----SVRIACNLRIRQSLGKQARVQRAIRLVFLVVIVFVLCFLPSIIAgllaLVFKNLGSCRCLNS 246
                       250       260       270
                ....*....|....*....|....*....|.
gi 84370244 314 QTVSWHFCIALGYTNSCLNPVLYAFLDENFK 344
Cdd:cd14991 247 VAQLFHISLAFTYLNSALDPVIYCFSSPWFR 277
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
75-347 2.02e-24

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 102.23  E-value: 2.02e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  75 YSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADA-LATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFT 153
Cdd:cd16004   7 YSLIVLVAVTGNATVIWIILAHRRMRTVTNYFIVNLALADLsMAAFNTAFNFVYASHNDWYFGLEFCRFQNFFPITAMFV 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 154 SIFTLCTMSVDRYIAVCHPVKaldfrtPR----NAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWE 229
Cdd:cd16004  87 SIYSMTAIAADRYMAIIHPFK------PRlsagSTKVVIAGIWLVALALAFPQCFYSTVTMDQGRTKCIVAWPGDSGGKH 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 230 NLL-KICVFIFAFIMPVLIITVCYGLMILRLKSvRMLSGSKEKDRNL------RRITRMVLVVVAVFIVCWTPIHIYVII 302
Cdd:cd16004 161 QLTyHLAVIVLIYLLPLAVMFVTYSIIGITLWR-SAVPGHQAHGAYHrqlqakKKFVKTMVVVVVTFAICWLPYHLYFIL 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 84370244 303 KAL-ITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd16004 240 GSFnEDIYCQKYIQQVYLAIFWLAMSSTMYNPIIYCCLNQRFRSGF 285
7tmA_GPR65_TDAG8 cd15365
proton-sensing G protein-coupled receptor 65, member of the class A family of ...
72-341 3.64e-24

proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors; The T cell death associated gene-8 receptor (TDAG8, also known as GPR65) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Activation of TDAG8 by extracellular acidosis increases the cAMP production, stimulates Rho, and induces stress fiber formation. TDAG8 has also been shown to regulate the extracellular acidosis-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages.


Pssm-ID: 320487 [Multi-domain]  Cd Length: 277  Bit Score: 101.40  E-value: 3.64e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  72 MALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQsVNYLMG--TWPFGTILCKIVISIDYY 149
Cdd:cd15365   4 PFVYIFVIVISIPSNCISLYVSCLQIRKKNELGVYLFNLSLSDLLYIVILPLW-IDYLWNgdNWTLSGFVCIFSAFLLYT 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 150 NMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGlPVMFMATTKYRQGSIDCTLTFSHPTWYWE 229
Cdd:cd15365  83 NFYTSTALLTCIALDRYLAVVHPLKFMHLRTIRTALSVSVAIWLLEICFN-AVILTWEDSFHESSSHTLCYDKFPLEDWQ 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 230 NLLKICVFIFAFIMPVLIITVCYGLMilrLKSVRMLSGSKEKDRnlRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIP 309
Cdd:cd15365 162 ARLNLFRICLGYLLPLLIILFCYWKI---YQAVRSNQATEDQEK--KKIFKLLLLITVTFVICFTPYHVVLLIRSIVEPC 236
                       250       260       270
                ....*....|....*....|....*....|....*
gi 84370244 310 ETTFQT---VSWHFCIALGYTNSCLNPVLYAFLDE 341
Cdd:cd15365 237 DCRNAKwlyTLYKITVALTSLNCIADPFLYCFVTE 271
7tmA_GPR4 cd15366
proton-sensing G protein-coupled receptor 4, member of the class A family of ...
74-341 4.69e-24

proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein-coupled receptor 4 (GPR4) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. GPR4 overexpression in melanoma cells was shown to reduce cell migration, membrane ruffling, and cell spreading under acidic pH conditions. Activation of GPR4 via extracellular acidosis is coupled to the G(s), G(q), and G(12/13) pathways.


Pssm-ID: 320488 [Multi-domain]  Cd Length: 280  Bit Score: 101.02  E-value: 4.69e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  74 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQsVNYLM--GTWPFGTILCKIVISIDYYNM 151
Cdd:cd15366   6 LYIIVIVLGLPTNCLALWAAYLQVRQRNELGVYLLNLSVSDLLYIATLPLW-IDYFLhrDNWIHGPESCKLFGFIFYTNI 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 152 FTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILS-SAIGLPVMFMATTKYRQGSIDCTLTFSHPTWY-WE 229
Cdd:cd15366  85 YISIAFLCCISVDRYLAVAHPLRFAKVRRVKTAVAVSAVVWAIEiGANSAPLFHDELFRDRYNHTFCFEKYPMEDWVaWM 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 230 NLLKICVfifAFIMPVLIITVCY-GLmilrLKSVRMLSGSKEKDRnlRRITRMVLVVVAVFIVCWTPIHIYVIIKALI-- 306
Cdd:cd15366 165 NLYRVFV---GFLFPWVLMLFSYrGI----LRAVRGNVSTEQQEK--AKIKRLALSLIAIVLLCFAPYHVLLLSRSVVyl 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 84370244 307 ------TIPETTFqtVSWHFCIALGYTNSCLNPVLYAFLDE 341
Cdd:cd15366 236 gkpcdcGFEERVF--TAYHVSLALTSLNCVADPILYCLVNE 274
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
73-336 5.40e-24

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 101.37  E-value: 5.40e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  73 ALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNM 151
Cdd:cd15058   5 LLLALIILAIVVGNLLVIIAIARTSRLQTMTNIFITSLACADlVMGLLVVPLGATIVVTGKWQLGNFWCELWTSVDVLCV 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 152 FTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIG-LPVMFMATTKYRQGSIDCtltFSHPTwywen 230
Cdd:cd15058  85 TASIETLCVIAVDRYIAITRPLRYQVLLTKRRARVIVCVVWIVSALVSfVPIMNQWWRANDPEANDC---YQDPT----- 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 231 llkICVF-----------IFAFIMPVLIITVCYG---------LMILRLKSVRMLSGSKE--------KDRNLRRITRMV 282
Cdd:cd15058 157 ---CCDFrtnmayaiassVVSFYIPLLIMIFVYArvfliatrqLQLIDKRRLRFQSECPApqttspegKRSSGRRPSRLT 233
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 84370244 283 LV-----------VVAVFIVCWTPIHIYVIIKALIT--IPETTFQTVSWhfciaLGYTNSCLNPVLY 336
Cdd:cd15058 234 VVkehkalktlgiIMGTFTLCWLPFFIANIINVFNRnlPPGEVFLLLNW-----LGYINSGLNPIIY 295
7tmA_NMBR cd15125
neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
71-347 6.77e-24

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320253 [Multi-domain]  Cd Length: 292  Bit Score: 101.18  E-value: 6.77e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  71 IMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST-LPFQSVNYLMGTWPFGTILCKIVISIDYY 149
Cdd:cd15125   3 IPSLYLLIITVGLLGNITLVKIFITNSAMRSVPNIFISSLAAGDLLLLVTcVPVDASRYFYEEWMFGTVGCKLIPVIQLT 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 150 NMFTSIFTLCTMSVDRYIAVCHPvkaLDFRTprNAKIVNVCN-----WILSSAIGLPVMFMATTKYRQGSIDCTLTFSHP 224
Cdd:cd15125  83 SVGVSVFTLTALSADRYKAIVNP---MDIQT--SSAVLRTCLkaiaiWVVSVLLAVPEAVFSEVAHIMPDDNTTFTACIP 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 225 TWYWENLL----KICVFIFAFIMPVLIITVCYGLMILRL-KSVRMLSG-----SKEKDRNLRRITRMVLVVVAVFIVCWT 294
Cdd:cd15125 158 YPQTDEMHpkihSVLIFLVYFLIPLAIISIYYYHIAKTLiKSAHNIPGeysehSKRQMETRKRLAKIVLVFVGLFAFCWF 237
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 84370244 295 PIHIYVIIKAL--ITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15125 238 PNHVLYMYRSFnyNEIDSSLGHMIVTLVARVLSFCNSCVNPFALYLLSESFRRHF 292
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
78-347 8.52e-24

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 100.58  E-value: 8.52e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  78 VCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLP-FQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIF 156
Cdd:cd15000   9 VVLFGIFGNFVLLYILASNRSLRTPTNLLIGNMALADLLTLLVCPwMFLVHDFFQNYVLGSVGCKLEGFLEGSLLLASVL 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 157 TLCTMSVDRYIAVCHPVKALdfRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGS----IDCTLTFSHPTWYWENLL 232
Cdd:cd15000  89 ALCAVSYDRLTAIVLPSEAR--LTKRGAKIVIVITWIVGLLLALPLAIYRSYRERQWKnfleTYCAENTQVLPIYWHVII 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 233 KICVFIfafimPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLR---RITRMVLVVVAVFIVCWTPIHIYVIIKALITIP 309
Cdd:cd15000 167 TVLVWL-----PLGIMLICYSAIFWKLDKYERRVLRREHPSVVRykkKAAKTLFIVLITFVVCRIPFTALIFYRYKLVPN 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 84370244 310 ETTFQTVS------WHFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15000 242 DNTQNSVSgsfhilWFASKYLMFLNAAVNPLIYGFTNENFRKAF 285
7tmA_mAChR_GAR-2-like cd15302
muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...
69-347 1.04e-23

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320429 [Multi-domain]  Cd Length: 266  Bit Score: 99.82  E-value: 1.04e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGT-WPFGTILCKIVISI 146
Cdd:cd15302   1 ILLALITAILSIITVIGNILVLLSFYVDRNIRQPSNYFIASLAVSDLLiGLESMPFYTVYVLNGDyWPLGWVLCDLWLSV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 147 DYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSI----DCTLTFS 222
Cdd:cd15302  81 DYTVCLVSIYTVLLITIDRYCSVKIPAKYRNWRTPRKVLLIIAITWIIPALLFFISIFGWQYFTGQGRSlpegECYVQFM 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 223 hptwywENLLKICVFIFAFIMPVLIItvcygLMILRLKSVRMlsgSKEKDRNLRRITrmvlVVVAVFIVCWTPIHIYVII 302
Cdd:cd15302 161 ------TDPYFNMGMYIGYYWTTLIV-----MLILYAGIYRA---ANRARKALRTIT----FILGAFVICWTPYHILATI 222
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 84370244 303 KALITIPE---TTFQTVSWHFCialgYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15302 223 YGFCEAPPcvnETLYTISYYLC----YMNSPINPFCYALANQQFKKTF 266
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
73-347 1.25e-23

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 100.37  E-value: 1.25e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  73 ALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNM 151
Cdd:cd15959   5 ALLSLAILVIVGGNLLVIVAIAKTPRLQTMTNVFVTSLACADlVMGLLVVPPGATILLTGHWPLGTTVCELWTSVDVLCV 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 152 FTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIG-LPVMfmaTTKYRQGS-IDCTLTFSHPtwywe 229
Cdd:cd15959  85 TASIETLCAIAVDRYLAITNPLRYEALVTKRRARTAVCLVWAISAAISfLPIM---NQWWRDGAdEEAQRCYDNP----- 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 230 nllKICVFI-----------FAFIMPVLIITVCYG-LMILRLKSVRMLSG------------SKEKDRNLRRITRMVL-- 283
Cdd:cd15959 157 ---RCCDFVtnmpyaivsstVSFYVPLLVMIFVYVrVFVVATRQVRLIRKdkvrfppeesppAESRPACGRRPSRLLAik 233
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 84370244 284 ---------VVVAVFIVCWTPIHIYVIIKALIT--IPETTFQTVSWhfciaLGYTNSCLNPVLYAfLDENFKRCF 347
Cdd:cd15959 234 ehkalktlgIIMGTFTLCWLPFFVANIIKVFCRslVPDPAFLFLNW-----LGYANSAFNPIIYC-RSPDFRSAF 302
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
69-345 1.72e-23

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 99.71  E-value: 1.72e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST-LPFQSVNYLMGTWPFGTILCKIVISID 147
Cdd:cd15083   1 YVLGIFILIIGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILnCPLMVISSFSGRWIFGKTGCDMYGFSG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 148 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQG-----SIDCTLTFS 222
Cdd:cd15083  81 GLFGIMSINTLAAIAVDRYLVITRPMKASVRISHRRALIVIAVVWLYSLLWVLPPLFGWSRYVLEGlltscSFDYLSRDD 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 223 HPTWYWenllkICVFIFAFIMPVLIITVCYGLMILRL------------KSVRMLSGSKEKDRNLR-RITRMVLVVVAVF 289
Cdd:cd15083 161 ANRSYV-----ICLLIFGFVLPLLIIIYCYSFIFRAVrrhekamkemakRFSKSELSSPKARRQAEvKTAKIALLLVLLF 235
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 84370244 290 IVCWTPIHIYVIIkALITIPET-TFQTVSWHFCIAlgYTNSCLNPVLYAFLDENFKR 345
Cdd:cd15083 236 CLAWTPYAVVALI-GQFGYLEVlTPLATAIPAAFA--KTSAIYNPVIYAFSHPKFRR 289
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
76-336 2.83e-23

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 99.43  E-value: 2.83e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  76 SIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATS-TLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTS 154
Cdd:cd15384   8 AVMFVISFIGNLLTIIQIYRLRRSRRTIYSLLLHLAIADLLVTFfCIPSEAIWAYTVAWLAGNTMCKLVKYLQVFGLYLS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 155 IFTLCTMSVDRYIAVCHPVKALdfRTPRNAKIVNVCNWILSSAIGLP--VMFMATTKYRQGSIDCTLTFSHPTWYW-ENL 231
Cdd:cd15384  88 TYITVLISLDRCVAILYPMKRN--QAPERVRRMVTVAWILSPIFSIPqaVIFHVERGPFVEDFHQCVTYGFYTAEWqEQL 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 232 LKICVFIFAFIMPVLIITVCYGLMILRL-KSVRMLSGSKEKDRNL------------RRITRMVLVVVAVFIVCWTPIHI 298
Cdd:cd15384 166 YNMLSLVFMFPIPLVIMVTCYVLIFITLsKSSRDFQGLEIYTRNRgpnrqrlfhkakVKSLRMSAVIVTAFILCWTPYYV 245
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 84370244 299 YVIIKALITIPETTFQTVSWHFciALGYTNSCLNPVLY 336
Cdd:cd15384 246 IMIWFLFFNPYPLNDILFDVIF--FFGMSNSCVNPLIY 281
7tmA_GPR31 cd15199
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G ...
69-344 2.98e-23

G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and sub-endothelial matrix, which is a critical step for metastasis.


Pssm-ID: 320327 [Multi-domain]  Cd Length: 278  Bit Score: 98.71  E-value: 2.98e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMG-TWPFGTILCKIVISID 147
Cdd:cd15199   1 IAYASLLILEFGLGLPGNAIALWTFIFRLKVWKPYAVYLLNLVLADVLLLICLPFKAYFYLNGnRWSLGGGTCKALLFML 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 148 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKyrqGSIDCTLTFSHPTWY 227
Cdd:cd15199  81 SLSRGVSIAFLTAVALDRYFRVVHPRGKKNSLSLQAAPYISFLVWLLLVGLTIPTLLASQPK---NFTECNSFSPKDDED 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 228 WENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKdrnLRRITRMVLVVVAVFIVCWTPIHIYVIIKALIT 307
Cdd:cd15199 158 FSDTWQEAVFFLQFLLPFGLIVFCTVRIIRRLKKRLRDVGKQPK---LQRAMALVTSVVVVFGFCFLPCFLARVLMLIFQ 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 84370244 308 IPETtfqtvSWHFCIA---------LGYTNSCLNPVLYAFLDENFK 344
Cdd:cd15199 235 NKES-----CNALNIAvhtydvtmcLTYLNSVLDPIVYCFSSPTFR 275
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
80-347 3.47e-23

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 98.97  E-value: 3.47e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  80 VVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST-LPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTL 158
Cdd:cd15312  12 LLTVFGNLMVIISISHFKQLHSPTNFLILSLAITDFLLGFLvMPYSMVRSVESCWYFGDLFCKIHSSLDMMLSTTSIFHL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 159 CTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFmaTTKYRQG------SIDCT----LTFSHptwYW 228
Cdd:cd15312  92 CFIAVDRYYAVCDPLHYRTKITTPVIKVFLVISWSVPCLFAFGVVF--SEVNLEGiedyvaLVSCTgscvLIFNK---LW 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 229 ENLLkicvFIFAFIMPVLIITVCYG-LMILRLKSVRMLS--------GSKEK--DRNLRRITRMVLVVVAVFIVCWTPIH 297
Cdd:cd15312 167 GVIA----SLIAFFIPGTVMIGIYIkIFFVARKHAKVINnrpsvtkgDSKNKlsKKKERKAAKTLSIVMGVFLLCWLPFF 242
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 84370244 298 IYVIIKALI--TIPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15312 243 VATLIDPFLnfSTPVDLFDALVW-----LGYFNSTCNPLIYGFFYPWFQKAF 289
7tmA_HCAR1-3 cd15201
hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G ...
77-347 1.22e-22

hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Hydroxycarboxylic acid receptor (HCAR) subfamily, a member of the class A G-protein coupled receptors (GPCRs), contains three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, or nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2 or GPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. Because nicotinic acid is capable of stimulating HCAR2 at higher concentrations only (in the range of sub-micromolar concentration), it is unlikely that nicotinic acts as a physiological ligand of HCAR2. All three receptors are expressed in adipocytes and mediate anti-lipolytic effects in fat cells through G(i) type G protein-dependent inhibition of adenylate cyclase.


Pssm-ID: 320329 [Multi-domain]  Cd Length: 281  Bit Score: 97.04  E-value: 1.22e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  77 IVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGT-WPFGTILCKIVISIDYYNMFTSI 155
Cdd:cd15201   9 LEFVLGLLGNGLALWIFCFHLKSWKSSTVYLFNLAVADFLLIICLPFRTDYYLRGKhWKFGDIPCRIVLFMLAMNRAGSI 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 156 FTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDC----TLTFSHPTWYWENL 231
Cdd:cd15201  89 FFLTAVAVDRYFRVVHPHHRINSISVRKAAIIACGLWLLTIAMTVYLLTKKHLFPRGNATQCesfnICTGTDSSSNWHEA 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 232 LkicvFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKekdrnLRRITRMVLVVVAVFIVCWTP-----IHIYVIIKALI 306
Cdd:cd15201 169 M----FLLEFFLPLAIILYCSVRIIWQLRGRQLDRHAK-----IKRAVQFIMVVAIVFIICFLPsnvtrIAIWILKHTSN 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 84370244 307 TI-PETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15201 240 EDcQYYRSVDLAFYITISFTYFNSMLDPVVYYFSSPSFKNFY 281
7tmA_GPR82 cd14996
orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G ...
74-347 1.23e-22

orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 82 of unknown function. GPR82 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320127 [Multi-domain]  Cd Length: 305  Bit Score: 97.57  E-value: 1.23e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  74 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGT-WPFGTILCKIVISID----Y 148
Cdd:cd14996   6 IYSFLFVTGVFGNLLSLWVFLTKISKKTSTHIYLINLVTANLLVCSAMPFQAAYFLKGFyWKYQSTQCRIANFFGtlviH 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 149 YNMFTSIFTLCTMSVDRY-IAVCH--------------PVKALD-FRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQ 212
Cdd:cd14996  86 VSMCVSILILSWIAISRYaTLMKHdsatqkqscyekifYGHFLKrFRQPKFARYLCIYIWGVVLCIIIPVVVYYSVREAD 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 213 GSIDcTLTFSHPTWYWENLLKICVFI---FAFIMPVLIITVCYGLmILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVF 289
Cdd:cd14996 166 EDGE-SLCYNRQVELGAKGSQIAGLIattFFFLFFLVVLLSYYSF-VNHLRRIQKNTCISEKDLIYRSVKRNILIIQALL 243
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 84370244 290 IVCWTPIHIYVIIKALITIPETTFQTVSW----HFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd14996 244 VVCFLPYHIFKPVFYVLHQREDCQQLNYLietkNILTCLASARSSTDPIMYLLLDKTFKKTL 305
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
69-345 1.35e-22

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 96.90  E-value: 1.35e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCKIVISID 147
Cdd:cd15401   1 SVLAGVLIFTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADlVVAVYPYPLILLAIFHNGWTLGNIHCQISGFLM 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 148 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWY 227
Cdd:cd15401  81 GLSVIGSVFNITAIAINRYCYICHSLRYDKLYNMKKTCCYVCLTWVLTLAAIVPNFFVGSLQYDPRIYSCTFAQTVSSSY 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 228 wenllKICVFIFAFIMPVLIITVCY---GLMILRLK-SVRMLSGSKEKDRNLRRITRMvLVVVAVFIVCWTPIHiYVIIK 303
Cdd:cd15401 161 -----TITVVVVHFIVPLSIVTFCYlriWVLVIQVKhRVRQDSKQKLKANDIRNFLTM-FVVFVLFAVCWGPLN-FIGLA 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 84370244 304 ALITIPETTFQTVSWHFCIA--LGYTNSCLNPVLYAFLDENFKR 345
Cdd:cd15401 234 VAINPLKVAPKIPEWLFVLSyfMAYFNSCLNAVIYGVLNQNFRK 277
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
66-347 2.14e-22

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 96.43  E-value: 2.14e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  66 VTAITIMALYSIVCVVGlfgNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCKIVI 144
Cdd:cd15301   1 VLIVIVAAVLSLVTVGG---NVMVMISFKIDKQLQTISNYFLFSLAVADfAIGVISMPLFTVYTALGYWPLGYEVCDTWL 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 145 SIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPvmFMATTKYRQGSID-----CTL 219
Cdd:cd15301  78 AIDYLASNASVLNLLIISFDRYFSVTRPLTYRARRTTKKAAVMIASAWIISLLLWPP--WIYSWPYIEGKRTvpagtCYI 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 220 TFSHPTWYwenlLKICVFIFAFIMPVLIITVCYGLMILRLKsvrmlsgsKEKDRNLRRITRMVLVVVAVFIVCWTPIHIY 299
Cdd:cd15301 156 QFLETNPY----VTFGTALAAFYVPVTIMCILYWRIWRETK--------KRQKKQESKAAKTLSAILLAFIVTWTPYNVL 223
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 84370244 300 VIIKALITIPETTfQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15301 224 VLIKAFFPCSDTI-PTELWDFSYYLCYINSTINPLCYALCNAAFRRTY 270
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
72-347 2.24e-22

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 96.88  E-value: 2.24e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  72 MALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYN 150
Cdd:cd15980   4 IASYLLIFLLCMMGNGVVCFIVLRSKHMRTVTNLFILNLAISDLLvGIFCMPTTLLDNIIAGWPFGSTVCKMSGMVQGIS 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 151 MFTSIFTLCTMSVDRYIAVCHPVKALdfRTPRNAKIVNVCNWILSSAIGLPVMFMATTK--------YRQGSIDCTLTFS 222
Cdd:cd15980  84 VSASVFTLVAIAVDRFRCIVYPFKQK--LTISTAVVIIVIIWVLAIAIMCPSAVMLHVQeeknyrvvLGSQNKTSPVYWC 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 223 HPTWYWENLLKI---CVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEK-------DRNLRRITRMVLVVVAVFIVC 292
Cdd:cd15980 162 REDWPNQEMRKIyttVLFANIYLAPLSLIVIMYARIGITLFKTAMPHTGKHNqeqrhvvSRKKQKVIKMLLIVALLFILS 241
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 84370244 293 WTPIHIYVIIKALITIPETTFQTVS---WHFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15980 242 WLPLWTLMMLSDYANLSPNQLQIINiyiYPFAHWLAFFNSSVNPIIYGFFNENFRRGF 299
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
71-347 2.63e-22

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 95.81  E-value: 2.63e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  71 IMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYY 149
Cdd:cd17790   3 IVITTGILSLVTVTGNLLVLISFKVNSELKTVNNYFLLSLACADlIIGAFSMNLYTTYILMGHWALGTVACDLWLALDYV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 150 NMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMatTKYRQGSIDCTLTFSHPTWYWE 229
Cdd:cd17790  83 ASNASVMNLLIISFDRYFSITRPLTYRAKRTPRRAAIMIGLAWLISFVLWAPAILF--WQYLVGERTVLAGQCYIQFLSQ 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 230 NLLKICVFIFAFIMPVLIitvcygLMILRLKSVRMLSGSKEKDRNLRRItrmvlvvVAVFIVCWTPIHIYVIIKALIT-- 307
Cdd:cd17790 161 PIITFGTAIAAFYLPVTI------MIILYWRIYRETIKEKKAARTLSAI-------LLAFILTWTPYNIMVLVSTFCKdc 227
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 84370244 308 IPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd17790 228 VPKTLWELGYW-----LCYVNSTVNPMCYALCNKSFRDTF 262
7tmA_GPR20 cd15163
G protein-coupled receptor 20, member of the class A family of seven-transmembrane G ...
69-344 2.92e-22

G protein-coupled receptor 20, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan GPR20 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR20 has been shown to constitutively activate G(i) proteins in the absence of a ligand; however its functional role is not known. GPR20 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320291 [Multi-domain]  Cd Length: 258  Bit Score: 95.63  E-value: 2.92e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTwpfGTILCKIVISIDY 148
Cdd:cd15163   1 LALMVINTLIFLVGIVLNSLALYVFCFRTKTKTTSVIYTINLVVTDLLVGLSLPTRIVMYYSAG---NCLTCSFVHIFSY 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 149 Y-NMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMfmaTTKYRQGSIDCTLTFShptwy 227
Cdd:cd15163  78 FvNMYCSILFLTCICVDRYLAIVQVEASRRWRNPNYAKGICVFIWLFAIVVTFSIL---TTAIKFASCCLSKLFA----- 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 228 wenllkicVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRnlrRITRMVLVVVAVFIVCWTPIHIYVIIKALIT 307
Cdd:cd15163 150 --------LTVFEFFLPLLIITFFTIRIMCALSRPGLMHQSRERRM---RAVQLLITVLIIFMICFTPFHVRQVAVAFNP 218
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 84370244 308 IPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFK 344
Cdd:cd15163 219 DIPHHTSLIVYHVTVTLSSLNSCMDPIVYCFVTNNFQ 255
7tmA_PAR2 cd15370
protease-activated receptor 2, member of the class A family of seven-transmembrane G ...
73-344 3.49e-22

protease-activated receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341349 [Multi-domain]  Cd Length: 280  Bit Score: 96.02  E-value: 3.49e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  73 ALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGT-WPFGTILCKIVISIDYYNM 151
Cdd:cd15370   5 IVYIIVFVVGLPSNAMALWVFLFRTKKKHPAVIYMANLALADLLFVIWFPLKIAYHINGNnWIYGEALCKVLIGFFYGNM 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 152 FTSIFTLCTMSVDRYIAVCHPVkALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQgsiDCTLTFSHPTWYwENL 231
Cdd:cd15370  85 YCSILFMTCLSVQRYWVIVNPM-SHSRKKANIAIGISLAIWLLILLVTIPLYLVKQTVFIP---ALDITTCHDVLP-EQL 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 232 LKICVFIF-------AFIMPVLIITVCYGLMILRLKSVrMLSGSKEKDRNlrRITRMVLVVVAVFIVCWTPIHIYVIIK- 303
Cdd:cd15370 160 LVGDMFNYflslaigVFLFPAFLTAVAYVLMIRALKSS-INDESIEKKRK--RAIKLIVTVLVMYLICFTPSNLLLVVHy 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 84370244 304 ALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFK 344
Cdd:cd15370 237 FLLKNQGQSSVYAFYITALCLSTLNSCIDPFVYYFVSHDFR 277
7tmA_GPR34-like cd15920
P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G ...
69-345 3.90e-22

P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR34 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR34 is shown to couple to G(i/o) protein and is highly expressed in microglia. Recently, lysophosphatidylserine has been identified as a ligand for GPR34. This group belongs to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320586 [Multi-domain]  Cd Length: 278  Bit Score: 95.64  E-value: 3.90e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQsVNYLMGTWPFgtILCKIVISIDY 148
Cdd:cd15920   1 VTLPVMYSIICIVGLLSNTLALWVFFLRQQRETSISVYMRNLALADLLLVLCLPFR-VAYQNTAGPL--SFCKIVGAFFY 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 149 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFmatTKYRQGSIDCTLTFSHPTWYW 228
Cdd:cd15920  78 LNMYASILFLSLISLDRYLKIIKPLQQFKIHTVPWSSAASGGVWLLLLACMIPFLF---ESRNEGPCDNKCFHFRSKGLT 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 229 ENLLKICVFIFAFIMPVLIItVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHI----YVI--I 302
Cdd:cd15920 155 AGGINLTAVVIFYILSLLFL-YFYAKISHKLYKVSLGNAQQQIKKASKRAIIKTFIVLAIFIVCFVPYHIvrvpYVLaqI 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 84370244 303 KALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKR 345
Cdd:cd15920 234 DVISSLPWKQTLHIANELVLCLSALNSCLDPIIYFFLSSSFRR 276
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
74-337 4.99e-22

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 95.72  E-value: 4.99e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  74 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFT 153
Cdd:cd15079   6 IYIFLGIVSLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDFLMMIKMPIFIYNSFYEGWALGPLGCQIYAFLGSLSGIG 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 154 SIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCnWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLK 233
Cdd:cd15079  86 SIWTNAAIAYDRYNVIVKPLNGNPLTRGKALLLILFI-WLYALPWALLPLLFGWGRYVPEGFLTSCSFDYLTRDWNTRSF 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 234 I-CVFIFAFIMPVLIITVCYGLMI---------LRLKSVRMLSGSKEKDRNLR------RITRMVLVVVAVFIVCWTPih 297
Cdd:cd15079 165 VaTIFVFAYVIPLIIIIYCYSFIVkavfahekaLREQAKKMNVVSLRSNADANkqsaeiRIAKVALTNVFLWFIAWTP-- 242
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 84370244 298 iYVII--------KALITiPETTfqtvSWHFCIAlgYTNSCLNPVLYA 337
Cdd:cd15079 243 -YAVValigafgnQSLLT-PLVS----MIPALFA--KTAACYNPIVYA 282
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
69-347 5.11e-22

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 95.25  E-value: 5.11e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATS-TLPFQSVNYLMGTWPFGTILCKIVISID 147
Cdd:cd15333   5 ISLAVLLALITLATTLSNAFVIATIYLTRKLHTPANYLIASLAVTDLLVSIlVMPISIVYTVTGTWTLGQVVCDIWLSSD 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 148 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWy 227
Cdd:cd15333  85 ITCCTASILHLCVIALDRYWAITDAVEYSKKRTPKRAAVMIALVWVISISISLPPFFWRQAKAEEEVSECVVNTDHILY- 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 228 wenllKICVFIFAFIMPVLIITVCYGlmilrlksvRMLSGSKEKDrnlRRITRMVLVVVAVFIVCWTPIHIYVIIKAlIT 307
Cdd:cd15333 164 -----TVYSTVGAFYIPTLLLIALYG---------RIYVEARARE---RKATKTLGIILGAFIVCWLPFFIISLVLP-IC 225
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 84370244 308 IPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15333 226 KDACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAF 265
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
74-347 9.00e-22

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 94.27  E-value: 9.00e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  74 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFqsVNYLM---GTWPFGTILCKIVISIDYY 149
Cdd:cd15310   6 SYCALILAIVFGNVLVCMAVLRERALQTTTNYLVVSLAVADLLvATLVMPW--VVYLEvtgGVWNFSRICCDVFVTLDVM 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 150 NMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNV---CNWILSSAIGLPVMFMATTkyrqgSIDCTL-TFSHPT 225
Cdd:cd15310  84 MCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVSLmitAVWVLAFAVSCPLLFGFNT-----TGDPTVcSISNPD 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 226 WYwenllkICVFIFAFIMPVLIITVCYGLMILRLksvrmlsgSKEKdrnlrRITRMVLVVVAVFIVCWTPIHIYVIIKA- 304
Cdd:cd15310 159 FV------IYSSVVSFYLPFGVTLLVYVRIYVVL--------LREK-----KATQMLAIVLGAFIVCWLPFFLTHILNTh 219
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 84370244 305 --LITIPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15310 220 cqACHVPPELYSATTW-----LGYVNSALNPVIYTTFNIEFRRAF 259
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
74-336 1.02e-21

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 94.93  E-value: 1.02e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  74 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMF 152
Cdd:cd15957   6 VMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADlVMGLAVVPFGAAHILLKTWTFGNFWCEFWTSIDVLCVT 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 153 TSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIG-LPVMFMATTKYRQGSIDCTLTFSHPTWYWENL 231
Cdd:cd15957  86 ASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSfLPIQMHWYRATHQEAINCYAEETCCDFFTNQA 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 232 LKICVFIFAFIMPVLIITVCYGLMIL----RLKSVRMLSGSKEKDRNLRRITRMVLVVVAVF------------------ 289
Cdd:cd15957 166 YAIASSIVSFYVPLVIMVFVYSRVFQeakrQLQKIDKSEGRFHNQNIDQNGSGGGGGNRRRSkfclkehkalktlgiimg 245
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 84370244 290 --IVCWTPIHIYVIIKAL--ITIPETTFQTVSWhfciaLGYTNSCLNPVLY 336
Cdd:cd15957 246 tfTLCWLPFFIVNIVHVIqdNLIRKEVYILLNW-----IGYVNSGFNPLIY 291
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
70-346 1.03e-21

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 94.65  E-value: 1.03e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  70 TIMALY-SIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTL-PFQSVNYLMGTWPFGTILCKIVISID 147
Cdd:cd15074   1 IIIGIYlTVIGILSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGyPLAIISAFAHRWLFGDIGCVFYGFCG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 148 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRnAKIVNVCNWILSS--AIgLPVMFMATTKYRQGSIDCTLTFSHPT 225
Cdd:cd15074  81 FLFGCCSINTLTAISIYRYLKICHPPYGPKLSRRH-VCIVIVAIWLYALfwAV-APLVGWGSYGPEPFGTSCSIDWTGAS 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 226 WYWENLL-KICVFIFAFIMPVLIITVCYGLMILRLKSVRML---SGSKEKDRNL--RRITRMVLVVVAVFIVCWTPihiY 299
Cdd:cd15074 159 ASVGGMSyIISIFIFCYLLPVLIIVFSYVKIIRKVKSSRKRvagFDSRSKRQHKieRKVTKVAVLICAGFLIAWTP---Y 235
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 84370244 300 VIIKALIT------IPETTFQTVSwhfciALGYTNSCLNPVLYAFLDENFKRC 346
Cdd:cd15074 236 AVVSMWSAfgspdsVPILASILPA-----LFAKSSCMYNPIIYLLFSSKFRQD 283
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
74-340 1.06e-21

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 94.03  E-value: 1.06e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  74 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPF-GTILCKIVISIDYYNMF 152
Cdd:cd14964   4 ILSLLTCLGLLGNLLVLLSLVRLRKRPRSTRLLLASLAACDLLASLVVLVLFFLLGLTEASSrPQALCYLIYLLWYGANL 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 153 TSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKyrqgSIDCTLTFSHPTWYWENLL 232
Cdd:cd14964  84 ASIWTTLVLTYHRYFALCGPLKYTRLSSPGKTRVIILGCWGVSLLLSIPPLVGKGAI----PRYNTLTGSCYLICTTIYL 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 233 KICVFIFAFIMPVLIITVCYGLMILRLKS---VRMLSGSKEKDRNLRRiTRMVLVVVAVFIVCWTPIHIYVIIKALITIP 309
Cdd:cd14964 160 TWGFLLVSFLLPLVAFLVIFSRIVLRLRRrvrAIRSAASLNTDKNLKA-TKSLLILVITFLLCWLPFSIVFILHALVAAG 238
                       250       260       270
                ....*....|....*....|....*....|.
gi 84370244 310 ETTFQTVSWHFciALGYTNSCLNPVLYAFLD 340
Cdd:cd14964 239 QGLNLLSILAN--LLAVLASTLNPFIYCLGN 267
7tmA_NAGly_R_GPR18 cd15166
N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G ...
69-344 1.15e-21

N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G protein-coupled receptors; N-arachidonyl glycine (NAGly), an endogenous metabolite of the endocannabinoid anandamide, has been identified as an endogenous ligand of the G(i/o) protein-coupled receptor 18 (GPR18). NAGly is involved in directing microglial migration in the CNS through activation of GPR18. NAGly-GPR18 signaling is thought to play an important role in microglial-neuronal communication. Recent studies also show that GPR18 functions as the abnormal cannabidiol (Abn-CBD) receptor. Abn-CBD is a synthetic isomer of cannabidiol and is inactive at cannabinoid receptors (CB1 or CB2), but acts as a selective agonist at GPR18. The NAGly receptor is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320294 [Multi-domain]  Cd Length: 275  Bit Score: 94.12  E-value: 1.15e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDY 148
Cdd:cd15166   1 IAALVFYSFIFIIGLFVNITALWVFSCTTKKRTTVTVYMMNVALVDLIFILSLPFRMVYYAKDEWPFGDYFCRILGALTV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 149 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYW 228
Cdd:cd15166  81 FYPSIALWLLAFISADRYMAIVQPKHAKELKNTPKAVLACVGVWIMTLASTFPLLFLYEDPDKASNFTTCLKMLDIIHLK 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 229 E-NLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMlsgSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIkALIT 307
Cdd:cd15166 161 EvNVLNFTRLIFFFLIPLFIMIGCYLVIIHNLVHGRT---SKLKPKVKEKSIRIIITLIVQVLVCFVPFHICFAF-LMLQ 236
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 84370244 308 IPETTFQTVSwHFCIALGYTNSCLNPVLYAFLDENFK 344
Cdd:cd15166 237 NGDNSYNPWA-AFTTFLMNLSTCLDVILYYIVSKQFQ 272
7tmA_ET-BR cd15976
endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
77-347 1.15e-21

endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320642 [Multi-domain]  Cd Length: 296  Bit Score: 94.92  E-value: 1.15e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  77 IVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST-LPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSI 155
Cdd:cd15976   9 LVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIIIdIPINVYKLLAEDWPFGVEMCKLVPFIQKASVGITV 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 156 FTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMF---MATTKYRQGSIDCTLTfsHPTW------ 226
Cdd:cd15976  89 LSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSIILAVPEAIgfdMITMDYKGELLRICLL--HPIQktafmq 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 227 YWENLLKICVFIFAFIMPVLIITVCYGLM---ILRLKSvRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIK 303
Cdd:cd15976 167 FYKTAKDWWLFSFYFCLPLACTAVFYTLMtceMLRKKN-GMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILK 245
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 84370244 304 ALITIPETTFQTVSWHFCIALGYT-------NSCLNPVLYAFLDENFKRCF 347
Cdd:cd15976 246 LTIYDEKDPNRCELLSFFLVLDYIginmaslNSCINPIALYLVSKRFKNCF 296
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
66-344 1.16e-21

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 94.48  E-value: 1.16e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  66 VTAITImalysIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVN-YLMGTWPFGTILCKIVI 144
Cdd:cd15132   3 VTIVCL-----ILFVVGVTGNTMTVLIIRRYKDMRTTTNLYLSSMAVSDLLILLCLPFDLYRlWKSRPWIFGEFLCRLYH 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 145 SIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFS-H 223
Cdd:cd15132  78 YISEGCTYATILHITALSIERYLAICFPLRAKVLVTRRRVKCVIAALWAFALLSAGPFLFLVGVEQDNNIHPDDFSREcK 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 224 PTWYWENLLKICVFIFA----FIMPVLIITVCYGLMILRL-KSVRMLSG--SKEKDRNLRRITRMVLVVVAVFIVCWTPI 296
Cdd:cd15132 158 HTPYAVSSGLLGIMIWVtttyFFLPMLCLSFLYGFIGRKLwKSKNDLRGpnAAARERSHRQTVRILAVVVLAFIICWLPF 237
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 84370244 297 HIYVIIkaLITIPETTFQTVSWHFCIA---LGYTNSCLNPVLYAFLDENFK 344
Cdd:cd15132 238 HIGRIL--FANTEDYRTMMFSQYFNIVamqLFYLSASINPILYNLISRKYR 286
7tmA_P2Y12-like cd15924
P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of ...
74-345 1.21e-21

P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y12-like receptors as well as closely related orphan receptor, GPR87.


Pssm-ID: 341352 [Multi-domain]  Cd Length: 284  Bit Score: 94.44  E-value: 1.21e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  74 LYSIVCVVGLFGNFLVMYVIVrYTKMKTATNIYIFNLALADALATSTLPFQSVNYL-MGTWPFGTILCKIVISIDYYNMF 152
Cdd:cd15924   6 LYTVIFFAGILLNGLAMWIFF-HIPSKSSFIIYLKNTVVADLLMILTFPFKILSDAgLGPWQLRTFVCRVTSVLFYFTMY 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 153 TSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSI-DCTLTFSHPTWYWENL 231
Cdd:cd15924  85 TSIVFLGLISIDRYLKIVRPFKTSFPKSVSFAKILSVVVWALMFLLSLPNMILTNQQPREKNVkKCSFLKSELGLKWHEI 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 232 LK-ICVFIFAFIMpvLIITVCYGLMILRL-KSVRMLSGSKEKDRnlRRITRMVLVVVAVFIVCWTPIHIyviikalITIP 309
Cdd:cd15924 165 VNyICQVIFWIVF--LLMIVCYTAITKKVyRSYRRVFRSSSSRR--KKSNVKIFIIVAVFFVCFVPYHF-------ARIP 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 84370244 310 ETTFQTVSWHFCIA-------------LGYTNSCLNPVLYAFLDENFKR 345
Cdd:cd15924 234 YTLSQTRDVFDCTAenilfyvkeatlfLSALNVCLDPIIYFFLCKSFRE 282
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
69-347 1.23e-21

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 93.94  E-value: 1.23e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCKIVISID 147
Cdd:cd15300   1 ITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADlIIGIFSMNLYTSYILMGYWALGSLACDLWLALD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 148 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFmaTTKYRQGSIDCTLTFSHPTWY 227
Cdd:cd15300  81 YVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPPIL--CWQYFVGKRTVPERECQIQFL 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 228 WENLLKICVFIFAFIMPVLIITVCYglmilrlksVRMLSGSKEKdrnlRRITRMVLVVVAVFIVCWTPIHIYVIIKALIT 307
Cdd:cd15300 159 SEPTITFGTAIAAFYIPVSVMTILY---------CRIYKETIKE----RKAAQTLSAILLAFIITWTPYNIMVLVSTFCS 225
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 84370244 308 --IPETTfqtvsWHFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15300 226 dcIPLTL-----WHLGYWLCYVNSTVNPMCYALCNKTFRKTF 262
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
77-338 1.26e-21

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 94.41  E-value: 1.26e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  77 IVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALA--TSTLPFQSVNYlMGTWPFGTILCKIVISIDYYNMFTS 154
Cdd:cd15197   9 VLFVFIVVGNSSVLFALWMRKAKKSRMNFFITQLAIADLCVglINVLTDIIWRI-TVEWRAGDFACKVIRYLQVVVTYAS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 155 IFTLCTMSVDRYIAVCHPVKALdfRTPRNAKIVNVCNWILSSAIGLPVMFMA-TTKYRQGSIDCTLTFSHPtWYWENLLK 233
Cdd:cd15197  88 TYVLVALSIDRYDAICHPMNFS--QSGRQARVLICVAWILSALFSIPMLIIFeKTGLSNGEVQCWILWPEP-WYWKVYMT 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 234 ICVFIFaFIMPVLIITVCYGLMI--------LRLKSVRMLSGSKEKDRNLRR--ITR-------MVLVVVAVFIVCWTPI 296
Cdd:cd15197 165 IVAFLV-FFIPATIISICYIIIVrtiwkkskIQVTINKAGLHDGSSRRSSSRgiIPRakiktikMTFVIVTVFIICWSPY 243
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 84370244 297 HIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAF 338
Cdd:cd15197 244 FVFDLLDVFGLLPRSKTKIAAATFIQSLAPLNSAINPLIYCL 285
7tmA_GPR174-like cd15152
putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G ...
75-345 1.28e-21

putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR174 has been recently identified as a lysophosphatidylserine receptor that enhances intracellular cAMP formation by coupling to a G(s) protein. GPR174 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320280 [Multi-domain]  Cd Length: 282  Bit Score: 94.41  E-value: 1.28e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  75 YSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTS 154
Cdd:cd15152   7 YTVILIPGLIGNVLALWVFYAYVKETKRAVIFMINLAIADLLQVLSLPLRIFYYLNKSWPFGKFLCMFCFYLKYVNMYAS 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 155 IFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIvNVCNWILSSAIGLPVMFMATTKYRQGSI--------DCTLTFShptw 226
Cdd:cd15152  87 IYFLVCISVRRCLYLIYPFRYNDCKRKCDVYI-SIAGWLVVCVGCLPFPLLRQSQDTNPTCcfadlplrNVGLTTS---- 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 227 yweNLLKICVFIFAFIMPVLIITVCYGLMILRLK-SVRMLSGSKEKDRNLrritRMVLVVVAVFIVCWTPIHIYVIIKAL 305
Cdd:cd15152 162 ---VIMLTIAELTGFVTPLLIVLYCSWKTVMSLReKTPVLQDLGEKKKAL----KMILTCAVVFLICFAPYHISFPLDFL 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 84370244 306 IT---IPETTFQTVSWHF---CIALGYTNSCLNPVLYAFLDENFKR 345
Cdd:cd15152 235 VKsnkIKSCTARKVILIFhpvALCLASLNSCLDPVIYYFTTDEFKR 280
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
69-347 1.59e-21

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 93.49  E-value: 1.59e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADA-LATSTLPFQSVNYLMGTWPFGTILCKIVISID 147
Cdd:cd15297   1 VFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLiIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 148 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMatTKYRQGSIDCTLTFSHPTWY 227
Cdd:cd15297  81 YVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILF--WQFIVGGRTVPEGECYIQFF 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 228 WENLLKICVFIFAFIMPVLIITVCYGLMilrlksvrmlsgSKEKDRNlRRITRMVLVVVAVFIVCWTPIHIYVIIKALIT 307
Cdd:cd15297 159 SNAAVTFGTAIAAFYLPVIIMTVLYWQI------------SRASSRE-KKVTRTILAILLAFIITWTPYNVMVLINTFCA 225
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 84370244 308 --IPETTfqtvsWHFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15297 226 scIPNTV-----WTIGYWLCYINSTINPACYALCNATFKKTF 262
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
77-345 1.98e-21

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 93.97  E-value: 1.98e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  77 IVCVVGLFGNFLVMYVIVR-YTKMKTATNIYIFNLALADALAT-STLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTS 154
Cdd:cd15383   9 VLFVLSACSNLAVLWSATRnRRRKLSHVRILILHLAAADLLVTfVVMPLDAAWNVTVQWYAGDLACRLLMFLKLFAMYSS 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 155 IFTLCTMSVDRYIAVCHPVKALDFRTpRNAKIVNVCnWILSSAIGLPVMFMATTKYRQGSID---CTLTFSHPTWYWENL 231
Cdd:cd15383  89 AFVTVVISLDRHAAILNPLAIGSARR-RNRIMLCAA-WGLSALLALPQLFLFHTVTATPPVNftqCATHGSFPAHWQETL 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 232 LKICVFIFAFIMPVLIITVCYGLMILRL-KSVRMLSGSKEKDRNLR-----------RITRMVLVVVAVFIVCWTPIHI- 298
Cdd:cd15383 167 YNMFTFFCLFLLPLLIMIFCYTRILLEIsRRMKEKKDSAKNEVALRsssdnipkarmRTLKMTIVIVSSFIVCWTPYYLl 246
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 84370244 299 ---YVIIKALI--TIPEttfqTVSwHFCIALGYTNSCLNPVLYAFLDENFKR 345
Cdd:cd15383 247 glwYWFSPEMLeqTVPE----SLS-HILFLFGLLNACLDPLIYGLFTISFRR 293
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
72-347 2.98e-21

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 93.47  E-value: 2.98e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  72 MALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATstlpfqsvnyLMGtwpfgtILCKIVISIDYYNM 151
Cdd:cd14968   4 IVLEVLIAVLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVG----------ALA------IPLAILISLGLPTN 67
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 152 F---------------TSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMF------MATTKY 210
Cdd:cd14968  68 FhgclfmaclvlvltqSSIFSLLAIAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFLVGLTPMFgwnngaPLESGC 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 211 RQGSIDCTLTFSHPTWYwenllkICVFIF-AFIM-PVLIITVCYGLMILR----LKSVRMLSGSKEKDRNLRR---ITRM 281
Cdd:cd14968 148 GEGGIQCLFEEVIPMDY------MVYFNFfACVLvPLLIMLVIYLRIFRVirkqLRQIESLLRSRRSRSTLQKevkAAKS 221
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 84370244 282 VLVVVAVFIVCWTPIHiyvIIKALITIPETTFQTVSW-HFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd14968 222 LAIILFLFALCWLPLH---IINCITLFCPECKVPKILtYIAILLSHANSAVNPIVYAYRIRKFRQTF 285
7tmA_ET-AR cd15975
endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G ...
77-347 3.12e-21

endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320641 [Multi-domain]  Cd Length: 300  Bit Score: 93.39  E-value: 3.12e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  77 IVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPF-----GTILCKIVISIDYYN 150
Cdd:cd15975   9 IIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIyIVIDIPINVYKLLAQKWPFddssfGVFLCKLVPFLQKAS 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 151 MFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLP---VMFMATTKYRQGSI-DCTLTFSHP-T 225
Cdd:cd15975  89 VGITVLNLCALSVDRYRAVASWSRVQGIGIPLITAIEIFSIWVLSFILAIPeaiGFVMVPFEYNGEQYrTCMLNATTKfM 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 226 WYWENLLKICVFIFAFIMPVLIITVCYGLMIL-----RLKSVRMLSGSKEKDRnlRRITRMVLVVVAVFIVCWTPIHIYV 300
Cdd:cd15975 169 NFYVDAKDWWLFGFYFCVPLACTAIFYTLMTCemlnrRKGSLRIALSEHLKQR--REVAKTVFCLVVIFALCWFPLHLSR 246
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 84370244 301 IIKALITIPET-------TFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15975 247 ILKKTVYNENDprrcellSFLLVMDYISINLATMNSCINPIALYFVSKKFKNCF 300
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
69-347 4.12e-21

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 92.96  E-value: 4.12e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALA-TSTLPFQSVNYLMGTWPFGTILCKIVISID 147
Cdd:cd15399   1 IVLILAYCSIILLGVVGNSLVIYVVIKFKNMRTVTNFFIANLAVADLMVnTLCLPFTLVYTLLDEWKFGAVLCHLVPYAQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 148 YYNMFTSIFTLCTMSVDRYIAVCHPVKAlDFRTPRNAKIVNVcNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWY 227
Cdd:cd15399  81 ALAVHVSTVTLTVIALDRHRCIVYHLES-KISKKISFLIIGL-TWAASALLASPLAIFREYSVIEISPDFKIQACSEKWP 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 228 WEN-----LLKICVFIFAFIMPVLIITVCYGLMILRLKS-VRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYV- 300
Cdd:cd15399 159 NGTlndgtIYSVSMLLIQYVLPLAIISYAYIRIWTKLKNhVSPGGGNDHYHQRRRKTTKMLVCVVVVFAVSWLPFHAFQl 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 84370244 301 ---IIKALITIPETTFQTVSWHFcIALGYTNSclNPVLYAFLDENFKRCF 347
Cdd:cd15399 239 asdIDSKVLDLKEYKLIYTIFHV-IAMCSTFA--NPLLYGWMNNNYRTAF 285
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
74-347 4.23e-21

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 92.44  E-value: 4.23e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  74 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMF 152
Cdd:cd15066   5 AMTLIILAAIFGNLLVIISVMRHRKLRVITNYFVVSLAMADMLvALCAMTFNASVEITGRWMFGYFMCDVWNSLDVYFST 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 153 TSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIG-LPVM--FMATTKYRQGSIdctltfSHPTwywe 229
Cdd:cd15066  85 ASILHLCCISVDRYYAIVQPLEYPSKMTKRRVAIMLANVWISPALISfLPIFlgWYTTEEHLQYRK------THPD---- 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 230 nllkICVFI-----------FAFIMPVLIITVCYglmilrlksVRMLSGSKEKdrnlRRITRMVLVVVAVFIVCWTPIHI 298
Cdd:cd15066 155 ----QCEFVvnkiyalisssVSFWIPCIVMIFTY---------YRIYLEAKRE----HKAAKTLGIIMGAFILCWLPFFL 217
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 84370244 299 YVIIKAL----ITIPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15066 218 WYVTTTLcgdaCPYPPILVSILFW-----IGYFNSTLNPLIYAYFNRDFREAF 265
7tmA_GPR35-like cd15164
G protein-coupled receptor 35 and similar proteins, member of the class A family of ...
69-344 5.34e-21

G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. Several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast. GPR35 couples to G(13) and G(i/o) proteins.


Pssm-ID: 320292 [Multi-domain]  Cd Length: 272  Bit Score: 92.32  E-value: 5.34e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFqsVNYLMGTWPFGTILCKIVISIDY 148
Cdd:cd15164   1 LIQLIIYIPILFFGLLFNVLALWVFCCKMKKWTETRVYMINLAVADCCLLFSLPF--VLYFLKHSWPDDELCLVLQSIYF 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 149 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILssaiglpVMFMATTKYRQGSIDCTLTFsHPTWYW 228
Cdd:cd15164  79 INRYMSIYIITAIAVDRYIAIKYPLKAKSLRSPRKAALTCGLLWVL-------VIISVSLRLAWEEQEENFCF-GKTSTR 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 229 ENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKdrNLRRITRMVLVVVAVFIVCWTPIHIYVIIK----- 303
Cdd:cd15164 151 PSKRTLIFSLLGFFIPLIILSFCSIQVIRSLKKKKKTNPHEEK--LIQKAIYIVSANLIVFIVCFLPLHIGLLVRfvmes 228
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 84370244 304 -----ALITIPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFK 344
Cdd:cd15164 229 nkascSLIQNIRNFIYVASC-----LANANCCLDAICYYFVAKEFQ 269
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
80-345 5.51e-21

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 92.61  E-value: 5.51e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  80 VVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTL 158
Cdd:cd15400  12 VVDILGNLLVIISVFRNRKLRNSGNVFVVSLALADlVVALYPYPLVLVAIFHNGWALGEMHCKVSGFVMGLSVIGSIFNI 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 159 CTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYwenllKICVFI 238
Cdd:cd15400  92 TGIAINRYCYICHSFAYDKLYSRWNTLLYVCLIWALTVVAIVPNFFVGSLEYDPRIYSCTFVQTASSSY-----TIAVVV 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 239 FAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDR----NLRRITRMvLVVVAVFIVCWTPIHIYVIIKAlITIPETTFQ 314
Cdd:cd15400 167 IHFIVPITVVSFCYLRIWVLVIQVRRKVKSESKPRlkpsDFRNFLTM-FVVFVIFAICWAPLNLIGLAVA-INPQEMAPK 244
                       250       260       270
                ....*....|....*....|....*....|...
gi 84370244 315 TVSWHFCIA--LGYTNSCLNPVLYAFLDENFKR 345
Cdd:cd15400 245 VPEWLFVVSyfMAYFNSCLNAIIYGLLNQNFRK 277
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
77-347 9.01e-21

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 91.44  E-value: 9.01e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  77 IVCVVGlfGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLP-FQSVNYLMGTWPFGTILCKIVISIDYYNMFTS 154
Cdd:cd15308  11 ILAIIA--GNVLVCLSVCTERALKTTTNYFIVSLAVADLLlALLVLPlYVYSEFQGGVWTLSPVLCDALMTMDVMLCTAS 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 155 IFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTfshptwywENLLKI 234
Cdd:cd15308  89 IFNLCAISVDRFIAVSVPLNYNRRQGSVRQLLLISATWILSFAVASPVIFGLNNVPNRDPAVCKLE--------DNNYVV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 235 CVFIFAFIMPVLIITVCYGLMILRLksvrmlsgSKEkdrnlRRITRMVLVVVAVFIVCWTPIHIYVIIKAL---ITIPET 311
Cdd:cd15308 161 YSSVCSFFIPCPVMLVLYCAMFRGL--------GRE-----RKAMRVLPVVVGAFLFCWTPFFVVHITRALcesCSIPPQ 227
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 84370244 312 TFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15308 228 LISIVTW-----LGYVNSALNPVIYTVFNAEFRNVF 258
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
69-351 1.00e-20

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 91.27  E-value: 1.00e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCKIVISID 147
Cdd:cd15213   1 ITLAILMILMIFVGFLGNSIVCLIVYQKPAMRSAINLLLANLAFSDiMLSLVCMPFAAVTIITGRWIFGDIFCRISAMLY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 148 YYNMFTSIFTLCTMSVDRYIAVchpVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFmATTKYRQGSIDCTLTFSHPTWY 227
Cdd:cd15213  81 WFFVLEGVAILLIISVDRYLII---VQRQDKLNPHRAKILIAVSWVLSFCVSFPPLV-GWGKYEFPPRAPQCVLGYTESP 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 228 WENLLKICVFIFAFIMPVLIITVCYgLMILRlkSVRMLsgskeKDRNLRRITRMvlvvVAVFIVCWTPIHIYVIIkALIT 307
Cdd:cd15213 157 ADRIYVVLLLVAVFFIPFLIMLYSY-FCILN--TVRSF-----KTRAFTTILIL----FIGFSVCWLPYTVYSLL-SVFS 223
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 84370244 308 IPETTFQTVSwHFCIALGYTNSCLNPVLYAFldenFKRCFREFC 351
Cdd:cd15213 224 RYSSSFYVIS-TCLLWLSYLKSAFNPVIYCW----RIKKFREAC 262
7tmA_NPY1R cd15395
neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G ...
71-345 1.06e-20

neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320517 [Multi-domain]  Cd Length: 293  Bit Score: 91.80  E-value: 1.06e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  71 IMAL-YSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALAT-STLPFQSVNYLMGTWPFGTILCKIVISIDY 148
Cdd:cd15395   2 TLALaYSAVIILGVSGNLALIIIILKQKEMHNVTNILIVNLSFSDLLMTiMCLPFTFVYTLMDHWVFGEAMCKLNSMVQC 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 149 YNMFTSIFTLCTMSVDRYIAVCHPvkaLDFR-TPRNAKIVNVCNWILSSAIGLPVM---------FMATTKYRQGSIDCT 218
Cdd:cd15395  82 ISITVSIFSLVLIAIERHQLIINP---RGWRpNNRHAYVGIAVIWVLAVLTSLPFLifqvltdepFKNVNVSLDAYKGKY 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 219 LTFSH-PTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKS----VRMLSGSKEKDRNLRRITRMVLVVVAVFIVCW 293
Cdd:cd15395 159 VCLDQfPSDTIRLSYTTCLLVLQYFGPLCFIFICYLKIYIRLKRrnnmMDKMRDNKYRSSETKRINIMLISIVVAFAVCW 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 84370244 294 TPIHIY-VIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKR 345
Cdd:cd15395 239 LPLNIFnAVFDWNHEAIATCNHNLLFLICHLTAMISTCVNPIFYGFLNKNFQR 291
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
70-261 1.91e-20

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 90.93  E-value: 1.91e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  70 TIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST-LPFQSVNYLMGTWPFGTILCKIVISIDY 148
Cdd:cd15336   2 TVGSVILIIGITGMLGNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTqSPIFFVNSLHKRWIFGEKGCELYAFCGA 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 149 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQG-SIDCT---LTFSHP 224
Cdd:cd15336  82 LFGITSMITLLAISLDRYLVITKPLASIRWVSKKRAMIIILLVWLYSLAWSLPPLFGWSAYVPEGlLTSCTwdyMTFTPS 161
                       170       180       190
                ....*....|....*....|....*....|....*..
gi 84370244 225 TWYWENLLkicvFIFAFIMPVLIITVCYGLMILRLKS 261
Cdd:cd15336 162 VRAYTMLL----FCFVFFIPLGIIIYCYLFIFLAIRS 194
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
70-347 2.00e-20

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 90.46  E-value: 2.00e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  70 TIMALYSIVCVVGlfgNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCKIVISIDY 148
Cdd:cd15298   5 TVTGSLSLVTVVG---NILVMLSIKVNRQLQTVNNYFLFSLACADlIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 149 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSI---DCTLTF-SHP 224
Cdd:cd15298  82 VVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVpdnQCFIQFlSNP 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 225 TwywenlLKICVFIFAFIMPVLIITVCYglMILRLKSVRMlsgskekdrnlRRITRMVLVVVAVFIVCWTPIHIYVIIKA 304
Cdd:cd15298 162 A------VTFGTAIAAFYLPVVIMTVLY--IHISLASARE-----------RKVTRTIFAILLAFILTWTPYNVMVLVNT 222
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 84370244 305 LIT--IPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15298 223 FCQscIPDTVWSIGYW-----LCYVNSTINPACYALCNATFKKTF 262
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
72-338 2.98e-20

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 90.63  E-value: 2.98e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  72 MALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADaLATSTlpFQSVNYLMG--TWPF-GT-ILCKIVISID 147
Cdd:cd15386   4 IGVLAAILVVATAGNLAVLLAMYRMRRKMSRMHLFVLHLALTD-LVVAL--FQVLPQLIWeiTYRFqGPdLLCRAVKYLQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 148 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDfRTPRNAKIVNVCNWILSSAIGLPVMFM-ATTKYRQGS--IDCTLTFSHP 224
Cdd:cd15386  81 VLSMFASTYMLIMMTVDRYIAVCHPLRTLQ-QPSRQAYLMIGATWLLSCILSLPQVFIfSLREVDQGSgvLDCWADFGFP 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 225 -------TWyweNLLKIcvfifaFIMPVLIITVCYGLMIL---------------------------RLKSVRMLSGSKe 270
Cdd:cd15386 160 wgakayiTW---TTLSI------FVLPVAILIVCYSLICYeicknlkgktqtsrsegggwrtqgmpsRVSSVRTISRAK- 229
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 84370244 271 kdrnlRRITRMVLVVVAVFIVCWTP---IHIYVIIKalITIPETTFQTVSWHFCIALGYTNSCLNPVLYAF 338
Cdd:cd15386 230 -----IRTVKMTFVIVLAYIACWAPffsVQMWSVWD--ENAPDEDSSDFAFTITMLLASLSSCCNPWIYMF 293
7tmA_PAFR cd15147
platelet-activating factor receptor, member of the class A family of seven-transmembrane G ...
75-345 4.41e-20

platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The platelet-activating factor receptor is a G(q/11)-protein coupled receptor, which is linked to p38 MAPK and PI3K signaling pathways. PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) which is synthesized by cells especially involved in host defense such as platelets, macrophages, neutrophils, and monocytes. PAF is well-known for its ability to induce platelet aggregation and anaphylaxis, and also plays important roles in allergy, asthma, and inflammatory responses, among many others.


Pssm-ID: 320275 [Multi-domain]  Cd Length: 291  Bit Score: 90.20  E-value: 4.41e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  75 YSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIF--NLALADALATSTLPFQSVNYL-MGTWPFGTILCKIVISIDYYNM 151
Cdd:cd15147   7 YSIIFVLGLIANCYVLWVFARLYPSKKLNEIKIFmvNLTIADLLFLITLPFWIVYYHnEGNWILPKFLCNVAGCLFFINT 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 152 FTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFM-ATTKYRQGSIDCTLTFSHPTWYWEN 230
Cdd:cd15147  87 YCSVAFLGVISYNRYQAVTRPIKTAQSTTRKRGIIISVAIWVIIVASASYFLFMdSTNTVKIDSGNFTRCFEGYEKDNSK 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 231 LLKICVF--IFAFIMPVLIITVCyGLMILRLKSVRMLSGSKEKDRNlRRITRMVLVVVAVFIVCWTPIHIyVIIKALITI 308
Cdd:cd15147 167 PVLIIHFiiIGLFFLVFLLILVC-NLVIARTLLSQPVQGQRNAGVK-RRALWMVCTVLAVFVICFVPHHV-VQGPWTLAV 243
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 84370244 309 PETTFQTVSW---------HFCIALGYTNSCLNPVLYAFLDENFKR 345
Cdd:cd15147 244 LQQWRYWDCQfrqalndahQITLCLMSTNCVLDPVIYCFLTKKFRK 289
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
69-345 8.60e-20

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 89.29  E-value: 8.60e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTA-TNIYIFNLALADALAT-STLPFQSVNYLMGTWPFGTILCKIVISI 146
Cdd:cd15382   1 LVSIIVYSVLFLIAAVGNLTVLLILLRNRRRKRSrVNILLMHLAIADLLVTfIMMPLEIGWAATVAWLAGDFLCRLMLFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 147 DYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRtpRNAKIVNVCNWILSSAIGLPVMFM-------ATTKYRQgsidCTL 219
Cdd:cd15382  81 RAFGLYLSSFVLVCISLDRYFAILKPLRLSDAR--RRGRIMLAVAWVISFLCSIPQSFIfhveshpCVTWFSQ----CVT 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 220 TFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRL----KSVRMLSGSKEKDRNLRRIT------------RMVL 283
Cdd:cd15382 155 FNFFPSHDHELAYNIFNMITMYALPLIIIVFCYSLILCEIsrksKEKKEDVSEKSSSVRLRRSSvgllerarsrtlKMTI 234
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 84370244 284 VVVAVFIVCWTPIHIYVIikalitipettfqtvsWHFCI----------------ALGYTNSCLNPVLYAFLDENFKR 345
Cdd:cd15382 235 VIVLVFIICWTPYFIMSL----------------WYWFDresaskvdpriqkglfLFAVSNSCMNPIVYGYFSIDLRR 296
7tmA_P2Y6 cd15379
P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled ...
73-345 1.13e-19

P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes mammalian P2Y6, avian P2Y3, and similar proteins. P2Y3 is the avian homolog of mammalian P2Y6. They belong to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320501 [Multi-domain]  Cd Length: 288  Bit Score: 88.78  E-value: 1.13e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  73 ALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGT-WPFGTILCKIVISIDYYNM 151
Cdd:cd15379   5 LVYSVVFLLGLPLNAVVIGQIWATRQALSRTTIYMLNLATADLLYVCSLPLLIYNYTQKDyWPFGDFTCRLVRFQFYTNL 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 152 FTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAK-IVNVCNWILSSAIGLPVMFMATTKYRQGSIDCtLTFSHP---TWY 227
Cdd:cd15379  85 HGSILFLTCISVQRYLGICHPLASWHKKKGKKLTwLVCGAVWLVVIAQCLPTFVFASTGTQRNRTVC-YDLSPParsTAY 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 228 WEnlLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLR-RITRMVLVVVAVFIVCWTPIHI----YVII 302
Cdd:cd15379 164 FP--YGITLTRTGFLLPFAARLACYCSMATILCRVVIAVAVVAAPGEKRgKAARMIIVVAAVFLISFLPFHYtktrYLQV 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 84370244 303 KALITIPETTFQ--TVSWHFCIALGYTNSCLNPVLYAFLDENFKR 345
Cdd:cd15379 242 RSWDGGPCTTRQafAEAYKRTRPFASMNSVLDPILFYFTQSKFRP 286
7tmA_ET-CR cd15977
endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled ...
77-347 1.21e-19

endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain. The ET-C receptor is specific for endothelin-3 on frog dermal melanophores; its activation causes dispersion of pigment granules.


Pssm-ID: 320643 [Multi-domain]  Cd Length: 296  Bit Score: 88.81  E-value: 1.21e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  77 IVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSI 155
Cdd:cd15977   9 VIFLVGIIGNSTLLRIIYKNKCMRNGPNVLIASLALGDLLyILIAIPINVIKLIAEDWPFGVHVCKLYPFIQKASVGITV 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 156 FTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLP--VMF-MATTKYRQGSIDCTLTFSHPT----WYW 228
Cdd:cd15977  89 LSLCALSIDRYRAVASWSRIRGIGIPVWKAVEVTLIWAVAIIVAVPeaIAFdMVEIDYRGQTLLVCMLPMEQTssfmRFY 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 229 ENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVR--MLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALI 306
Cdd:cd15977 169 QDVKDWWLFGFYFCLPLACTGVFYTLMSCEMLSIKngMRIALNDHMKQRREVAKTVFCLVVIFALCWLPLHLSRILKKTI 248
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 84370244 307 TIPETTFQTVSWHFCIALGYT-------NSCLNPVLYAFLDENFKRCF 347
Cdd:cd15977 249 YDVKDPQRCELLSFLLVMDYTginmaslNSCINPVALYFVSRKFKNCF 296
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
77-350 1.64e-19

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 88.04  E-value: 1.64e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  77 IVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMG-TWPFGTILCKIVISIDYYNMFTS 154
Cdd:cd15305   9 IIIILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLvGILVMPVSLIAILYDyAWPLPRYLCPIWISLDVLFSTAS 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 155 IFTLCTMSVDRYIAVCHPVKALDF--RTPRNAKIVNVcnWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHptwywENLL 232
Cdd:cd15305  89 IMHLCAISLDRYVAIRNPIEHSRFnsRTKAMMKIAAV--WTISIGISMPIPVIGLQDDEKVFVNGTCVLND-----ENFV 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 233 KICVFIfAFIMPVLIITVCYGLMILRLKsvrmlsgSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALI------ 306
Cdd:cd15305 162 LIGSFV-AFFIPLIIMVITYCLTIQVLQ-------RQQAINNERRASKVLGIVFFLFLIMWCPFFITNILSVLCkeacdq 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 84370244 307 TIPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCFREF 350
Cdd:cd15305 234 KLMEELLNVFVW-----VGYVSSGINPLVYTLFNKTYRRAFSNY 272
7tmA_GRPR cd15124
gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
71-347 1.68e-19

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320252 [Multi-domain]  Cd Length: 293  Bit Score: 88.42  E-value: 1.68e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  71 IMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST-LPFQSVNYLMGTWPFGTILCKIVISIDYY 149
Cdd:cd15124   3 IPTVYGIIILIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTcAPVDASRYLADEWLFGRVGCKLIPFIQLT 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 150 NMFTSIFTLCTMSVDRYIAVchpVKALDFRTPRnaKIVNVC-----NWILSSAIGLP-VMFMATTKYRQGSIDCTLT--- 220
Cdd:cd15124  83 SVGVSVFTLTALSADRYKAI---VRPMDIQASN--ALMKIClkaalIWILSMLLAIPeAVFSDLHPFYDKSTNKTFVsca 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 221 -FSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLM---ILRLKSVRMLSG---SKEKDRNLRRITRMVLVVVAVFIVCW 293
Cdd:cd15124 158 pYPHSNELHPKIHSMASFLIFYVIPLSIISVYYYFIaknLIRSAYNLPVEGnvhVRRQIESRKRLAKTVLVFVGLFAFCW 237
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 84370244 294 TPIHIYVIIKaliTIPETTFQTVSWHFCIA-----LGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15124 238 LPNHIIYLYR---SYHYSEVDTSMLHFVSSicariLAFTNSCVNPFALYLLSKSFRKQF 293
7tmA_SUCNR1_GPR91 cd15378
succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
73-344 1.74e-19

succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Succinate receptor (SUCNR1) GPR91 exclusively couples to G(i) protein to inhibit cAMP production and also activates PLC-beta to increase intracellular calcium concentrations in an inositol phosphate dependent mechanism. Succinate, an intermediate molecule of the citric cycle, is shown to cause cardiac hypertrophy via GPR91 activation. Furthermore, succinate-induced GPR91 activation is involved in the regulation of renin-angiotensin system and is suggested to play an important role in the development of renovascular hypertension and diabetic nephropathy. SUCNR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC).


Pssm-ID: 320500 [Multi-domain]  Cd Length: 283  Bit Score: 88.23  E-value: 1.74e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  73 ALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMF 152
Cdd:cd15378   5 TMYSIEFVLGFIGNTIVILGYIFCLKNWKSSNIYLFNLSVSDLAFLCTLPMLVYSYSNGQWLFGDFLCKSNRYLLHANLY 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 153 TSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCtLTFSHPTWYWENLL 232
Cdd:cd15378  85 SSILFLTFISIDRYLLIKYPFREHILQKKRSAVAISLAIWVLVTLELLPILTFIGPNLKDNVTKC-KDYASSGDATNSLI 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 233 -KICVFIFAFIMPVLIITVCYGLMILRLKSvrmLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKAL-----I 306
Cdd:cd15378 164 ySLFLTVTGFLIPLCVMCFFYYKIALFLKN---RNRQLANATSFEKPLTLVILAVVIFSVLFTPYHVMRNVRIAsrldsI 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 84370244 307 TIPETTFQTVSWHFCIA--LGYTNSCLNPVLYAFLDENFK 344
Cdd:cd15378 241 GVSECTLIIIKSLYIVTrpIAFLNSVINPVFYFLMGDHFR 280
7tmA_GPR132_G2A cd15364
proton-sensing G protein-coupled receptor 132, member of the class A family of ...
69-345 4.29e-19

proton-sensing G protein-coupled receptor 132, member of the class A family of seven-transmembrane G protein-coupled receptors; The G2 accumulation receptor (G2A, also known as GPR132) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. G2A was originally identified as a stress-inducible receptor that causes the cell cycle arrest at G2/M phase when serum is deprived. Lysophosphatidylcholine was identified as a ligand for G2A, and whose overexpression was shown to induce cell proliferation, oncogenic transformation, and apoptosis.


Pssm-ID: 320486 [Multi-domain]  Cd Length: 279  Bit Score: 87.14  E-value: 4.29e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVnYLMGT--WPFGTILCKIVISI 146
Cdd:cd15364   1 IFLVVVYSVVFALGFPANCLTLWLTLLQVRRKNVLAVYLFSLSLCELLYLGTLPLWTI-YVSNNhkWPWGSLACKITGYI 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 147 DYYNMFTSIFTLCTMSVDRYIAVchpVKALDFRTPRNAKIVNVCNWILSSAIGL---PVmFMATTKYRQGSIDCTLTFSH 223
Cdd:cd15364  80 FFCNIYISILLLCCISIDRFVAV---VYALESRGRRRQRIAAFISFLIFIVVGLvhsPV-FIMREGQTEGSHTCFETLQM 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 224 PTwywenllKICVFIFAfimpVLIITVCYGLMILRLKSVRMLSGSKEKD----RNLRRITRMVLVVVAVFIVCWTPIHIY 299
Cdd:cd15364 156 DT-------QVAGFYYA----RFCIGFAIPLAILIFTNYRIFRSIQTSTsltpHQKAKVKYLAIAVIVIFLICFAPYHLV 224
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 84370244 300 VIIKALITIP--------ETTFQTVSWHFcIALGYTNSCLNPVLYAFLDENFKR 345
Cdd:cd15364 225 LLVRAIAFSLypngmcgfEERIYTPSVIF-LCLSTVNSVADPIIYVLVSENVRQ 277
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
77-345 4.86e-19

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 86.84  E-value: 4.86e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  77 IVCVVGLF----GNFLVMYVIVRYTKMKTATNIYIFNLALADALATST-LPFQSVNYLMGTWPFGTILCKIVISIDYYNM 151
Cdd:cd15318   5 LACAIGMLiivlGNLFVVVTVSHFKALHTPTNFLLLSLALADMLLGLTvLPFSTIRSVESCWYFGDSFCRLHTCLDTLFC 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 152 FTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSI--------DCTLTFSH 223
Cdd:cd15318  85 LTSIFHLCFISIDRHCAICDPLLYPSKFTIRVACIFIAAGWLVPTVYTSVFLYTKAVEEGLAELltsvpcvgSCQLLYNK 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 224 pTWYWENLLkicvfifAFIMPVLIITVCYG-LMILRLKSVRM----LSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHI 298
Cdd:cd15318 165 -LWGWLNFP-------VFFIPCLIMIGLYVkIFIVAKRQARAiaslLSDTNGASKRERKAAKTLGIAVGVYLLCWLPFTI 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 84370244 299 YVIIKALITI--PETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKR 345
Cdd:cd15318 237 DTMVDSLLNFitPPLLFDIIIW-----FAYFNSACNPLIYVFSYPWFRK 280
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
72-345 6.26e-19

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 86.13  E-value: 6.26e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  72 MALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALAT--STLP---------FQSvnylmgtwpfGTILC 140
Cdd:cd15196   4 IAVLATILVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLVAlfNVLPqliwdityrFYG----------GDLLC 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 141 KIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFrTPRNAKIVNVCNWILSSAIGLPVMFMAT-TKYRQGSIDCTL 219
Cdd:cd15196  74 RLVKYLQVVGMYASSYVLVATAIDRYIAICHPLSSHRW-TSRRVHLMVAIAWVLSLLLSIPQLFIFSyQEVGSGVYDCWA 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 220 TFSHPtwyWENLLKICVFIFA-FIMPVLIITVCYGLMIL-----RLKSVrmlsgskekdrnlrritRMVLVVVAVFIVCW 293
Cdd:cd15196 153 TFEPP---WGLRAYITWFTVAvFVVPLIILAFCYGRICYvvwraKIKTV-----------------KLTLVVVACYIVCW 212
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 84370244 294 TPIHIYVIIKALitIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKR 345
Cdd:cd15196 213 TPFFVVQMWAAW--DPTAPIEGPAFVIIMLLASLNSCTNPWIYLAFSGNLRR 262
7tmA_GPR34-like cd15148
putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G ...
73-345 6.60e-19

putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 34 of unknown function. Orphan GPR34 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320276 [Multi-domain]  Cd Length: 282  Bit Score: 86.67  E-value: 6.60e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  73 ALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMG-TWPFGTILCKIVISIDYYNM 151
Cdd:cd15148   5 VFYSLIFLFGLVGNLLALWVFLFIHRKRNSVRIFLINVAIADLLLIICLPFRILYHVNNnQWTLGPLLCKVVGNLFYMNM 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 152 FTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATtkyrqGSIDCTLTFSHPTWY---W 228
Cdd:cd15148  85 YISIILLGFISLDRYLKINRSSRRQKFLTRKWSIVACGVLWAVALVGFVPMIVLTE-----KNEESTKCFQYKDRKnakG 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 229 ENllkicvfIFAFIMpVLIITVCYGLMILRLKSV--RMLSGSKEKDR-----NLRRITRMVLVVVAVFIVCWTPIH---I 298
Cdd:cd15148 160 KA-------IFNFLI-VAMFWLVFLLLILSYGKIakKLLRISRDKPDfpnaaKYNRTARKSFFVLFIFTVCFVPYHafrI 231
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 84370244 299 YVIIKALITIPETTFQTVswHFC----IALGYTNSCLNPVLYAFLDENFKR 345
Cdd:cd15148 232 FYITSQLQNNSCYWKEIL--HKTneimLLLSAFNSCLDPVMYFLLSSSIRK 280
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
69-348 6.62e-19

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 86.54  E-value: 6.62e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCKIVISID 147
Cdd:cd15299   4 VLIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADlIIGVISMNLFTTYIIMNRWALGNLACDLWLSID 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 148 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMatTKYRQGSIDCTLTFSHPTWY 227
Cdd:cd15299  84 YVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILF--WQYFVGKRTVPPDECFIQFL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 228 WENLLKICVFIFAFIMPVLIITVCYglmilrLKSVRMLSGSKEKDRNLRRItrmvlvvVAVFIVCWTPIHIYVIIKALIT 307
Cdd:cd15299 162 SEPIITFGTAIAAFYLPVTIMTILY------WRIYKETIKEKKAAQTLSAI-------LLAFIITWTPYNIMVLVNTFCD 228
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 84370244 308 --IPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCFR 348
Cdd:cd15299 229 scIPKTYWNLGYW-----LCYINSTVNPVCYALCNKTFRTTFK 266
7tmA_NTSR1 cd15355
neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...
69-347 1.63e-18

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320477 [Multi-domain]  Cd Length: 310  Bit Score: 86.05  E-value: 1.63e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMK---TATNIYIFNLALADALATS-TLPFQSVNYLM--GTWPFGTILCKi 142
Cdd:cd15355   1 VLVTAIYLALFVVGTVGNSITLYTLARKKSLQhlqSTVHYHLASLALSDLLILLlAMPVELYNFIWvhHPWAFGDAACR- 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 143 visiDYYNM-----FTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQ----G 213
Cdd:cd15355  80 ----GYYFLrdactYATALNVASLSVERYLAICHPFKAKSLMSRSRTKKFISAIWLASALLAIPMLFTMGEQNRSgthpG 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 214 SIDCTLTFSHPTwyWENLLKICVFIfAFIMPVLIITVCYGLMILRLKSV-----------------RMLSGSKEKDR--N 274
Cdd:cd15355 156 GLICTPIVDTST--LKVVIQVNAFL-SFLFPMLVISVLNTLIANQLTVMvnqaeqenqvctiggqrTVLSVSMEPGRvqS 232
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 275 LRRITRMVLVVVAVFIVCWTPIHIYVIIkaLITIPETTFQTVSWHF-------CIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15355 233 LRHGVLVLRAVVIAFVVCWLPYHVRRLM--FCYVSDEQWTTFLYDFyhyfymlTNVLFYVSSAINPILYNLVSANFRQIF 310
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
71-347 1.63e-18

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 84.98  E-value: 1.63e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  71 IMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISIDYY 149
Cdd:cd15335   3 IVLTLALITILTTVLNSAVIAAICTTKKLHQPANYLICSLAVTDFLvAVLVMPLSITYIVMDTWTLGYFICEIWLSVDMT 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 150 NMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWywe 229
Cdd:cd15335  83 CCTCSILHLCVIALDRYWAITDAIEYARKRTAKRAGLMILTVWTISIFISIPPLFWRNHHDANIPSQCIIQHDHVIY--- 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 230 nllKICVFIFAFIMPVLIITVCYglmilrlksVRMLSGSKEKdrnlRRITRMVLVVVAVFIVCWTPIHIYVIIKAL--IT 307
Cdd:cd15335 160 ---TIYSTFGAFYIPLTLILILY---------YRIYHAASRE----RKAARILGLILGAFILSWLPFFIKELIVGLsvMT 223
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 84370244 308 IPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15335 224 VSPEVADFLTW-----LGYVNSLVNPLLYTSFNEDFKLAF 258
7tmA_ET_R cd15128
endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
77-347 1.70e-18

endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are 21-amino acid peptides which able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320256 [Multi-domain]  Cd Length: 300  Bit Score: 85.65  E-value: 1.70e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  77 IVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPF-----GTILCKIVISIDYYN 150
Cdd:cd15128   9 LIFIVGIIGNSTLLRIIYQNKCMRNGPNALIASLALGDLLyIVIDLPINVYKLLAMDWPFgdqpfGQFLCKLVPFIQKAS 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 151 MFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMF---MATTKYRQGSIDCTLTFSHPTW- 226
Cdd:cd15128  89 VGITVLNLCALSVDRYRAVASWSRIQGIGIPMWTAVEIVMIWMLSAVLAVPEAIgfdMVRFNYKGVTLRTCLLRPETSFm 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 227 -YWENLLKICVFIFAFIMPVLIITVCYGLM---ILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVII 302
Cdd:cd15128 169 kFYIDVKDWWLFGFYFCLPLVCTAIFYTLMtceMLRKRNGMLRIALNEHLKQRREVAKTVFCLVVIFALCWLPLHLSRIL 248
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 84370244 303 KALITIPET-------TFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15128 249 KLTVYDQNDpnrcellSFLLVLDYFGINLATLNSCINPIALYFVSRKFKNCF 300
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
74-347 1.76e-18

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 84.98  E-value: 1.76e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  74 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMG-TWPFGTILCKIVISIDYYNM 151
Cdd:cd15304   6 LTVIVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLlGFLVMPVSMLTILYGyRWPLPSKLCAVWIYLDVLFS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 152 FTSIFTLCTMSVDRYIAVCHPVKALDF--RTPRNAKIVNVcnWILSSAIGLPVMFMA----TTKYRQGSidCTLTFshpt 225
Cdd:cd15304  86 TASIMHLCAISLDRYIAIRNPIHHSRFnsRTKAFLKIIAV--WTISVGISMPIPVFGlqddSKVFKEGS--CLLAD---- 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 226 wywENLLKICVFIfAFIMPVLIITVCYGLMILRLksvrmlsgsKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIkAL 305
Cdd:cd15304 158 ---ENFVLIGSFV-AFFIPLTIMVITYFLTIKSL---------QQSISNEQKASKVLGIVFFLFVVMWCPFFITNVM-AV 223
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 84370244 306 ITIPETTFQTVS--WHFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15304 224 ICKESCNEVVIGglLNVFVWIGYLSSAVNPLVYTLFNKTYRSAF 267
7tmA_D1B_dopamine_R cd15319
D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
73-347 1.80e-18

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320442 [Multi-domain]  Cd Length: 317  Bit Score: 85.78  E-value: 1.80e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  73 ALYSIVCVVGLFGNFLVMYVIVRYTKMKT-ATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTiLCKIVISIDYYN 150
Cdd:cd15319   5 CLLSLLILWTLLGNILVCAAVVRFRHLRSkVTNIFIVSLAVSDLFvALLVMPWKAVAEVAGYWPFGA-FCDVWVAFDIMC 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 151 MFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIG-LPVMF-----MATTkyrQGSIDCTLTFSHP 224
Cdd:cd15319  84 STASILNLCVISVDRYWAISSPFRYERKMTQRVALVMISVAWTLSVLISfIPVQLnwhkdSGDD---WVGLHNSSISRQV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 225 TWYWENLLK----ICVFIFAFIMPVLIITVCYG-------LMILRLKSVRMLSGSKEKDRNLR----------------- 276
Cdd:cd15319 161 EENCDSSLNrtyaISSSLISFYIPVAIMIVTYTriyriaqIQIRRISSLERAAEHAQSCRSNRidchhhtslrtsikket 240
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 277 RITRMVLVVVAVFIVCWTPIHIYVII------------KALITIPETTFQTVSWhfciaLGYTNSCLNPVLYAFlDENFK 344
Cdd:cd15319 241 KVLKTLSVIMGVFVCCWLPFFILNCMvpfcdrppadpdAGLPCVSETTFDVFVW-----FGWANSSLNPIIYAF-NADFR 314

                ...
gi 84370244 345 RCF 347
Cdd:cd15319 315 KVF 317
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
76-347 1.82e-18

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 85.83  E-value: 1.82e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  76 SIVCVVGLFGNFLVMYVIVRYTKMKT-ATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTiLCKIVISIDYYNMFT 153
Cdd:cd15320   9 SVLILSTLLGNTLVCAAVIRFRHLRSkVTNFFVISLAVSDLLvAVLVMPWKAVAEIAGFWPFGS-FCNIWVAFDIMCSTA 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 154 SIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIG-LPVMF----MATTKYRQGSIDC-TLTFSHPTWY 227
Cdd:cd15320  88 SILNLCVISVDRYWAISSPFRYERKMTPKVAFIMISVAWTLSVLISfIPVQLnwhkAKPTSFLDLNASLrDLTMDNCDSS 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 228 WENLLKICVFIFAFIMPVLIITVCYgLMILRL--KSVRMLSG----------------------SKEKDRNLR------- 276
Cdd:cd15320 168 LNRTYAISSSLISFYIPVAIMIVTY-TRIYRIaqKQIRRISAleraavhakncqnstgnrgsgdCQQPESSFKmsfkret 246
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 84370244 277 RITRMVLVVVAVFIVCWTPIHIYVII--------KALITIPETTFQTVSWhfciaLGYTNSCLNPVLYAFlDENFKRCF 347
Cdd:cd15320 247 KVLKTLSVIMGVFVCCWLPFFILNCMvpfckptsTEPFCISSTTFDVFVW-----FGWANSSLNPIIYAF-NADFRKAF 319
7tmA_NPY6R cd15396
neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G ...
75-345 2.22e-18

neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320518 [Multi-domain]  Cd Length: 293  Bit Score: 85.27  E-value: 2.22e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  75 YSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST-LPFQSVNYLMGTWPFGTILCKIVISIDYYNMFT 153
Cdd:cd15396   7 YSVVTIVGLFGNLCLITIIKKQKEEHNVTNILIANLSLSDVLVCVMcIPFTAVYTLMDHWIFGETMCKLTSFVQSVSVSV 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 154 SIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVcnWILSSAIGLP-VMFMATTK--YRQGSIDCTLTFSH------- 223
Cdd:cd15396  87 SIFSLVLIAIERYQLIVNPRGWKPSASHAYWGIVLI--WLFSLMISIPfLIFHQLTDepFRNLSSHSDFYKDKvvcieaw 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 224 PTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVR-MLSGSKEKDRNL---RRITRMVLVVVAVFIVCWTPIHIY 299
Cdd:cd15396 165 PSETERLIFTTSLLVFQYFVPLGFIFICYLKIFVCLKKRNsKIDRMRENESRLsenKRINTMLISIVVTFAACWLPLNIF 244
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 84370244 300 VII-----KALItipeTTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKR 345
Cdd:cd15396 245 NVVfdwnhEVLM----SCHHNLVFTLCHLVAMVSTCINPIFYGFLNKNFQK 291
7tmA_P2Y11 cd15376
P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled ...
73-346 2.90e-18

P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y11 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. The activation of P2Y11 is a major pathway of macrophage activation that leads to the release of cytokines. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320498 [Multi-domain]  Cd Length: 284  Bit Score: 84.75  E-value: 2.90e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  73 ALYSIVCVVGLFGNFLVMYVIV-RYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMG-TWPFGTILCKIVISIDYYN 150
Cdd:cd15376   5 PILGVEFLVAVLGNGLALWLFVtRERRPWHTGVVFSFNLAVSDLLYALSLPLLAAYYYPPkNWRFGEAACKLERFLFTCN 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 151 MFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGS-IDCTLTFSHPTWYwe 229
Cdd:cd15376  85 LYGSIFFITCISLNRYLGIVHPFFTRSHVRPKHAKLVSLAVWLLVAALSAPVLSFSHLEVERHNkTECLGTAVDSRLP-- 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 230 NLLKICVFIFAF--IMPVLIITVCYGLMI---LRLKSVRMLsgskEKdrnlRRITRMvlvvvavfivcwtpIHIYVIIKA 304
Cdd:cd15376 163 TYLPYSLFLAVVgcGLPFLLTLASYLAIVwavLRSPGITTL----EK----RKVAAL--------------VAVVVALYA 220
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 84370244 305 LITIPETTFQTV------SWHFC-----IALGYT--------NSCLNPVLYAFLDENFKRC 346
Cdd:cd15376 221 VSFVPYHILRNLnlyrrlQWLKAaaslrIYFAYQvtkglvtlNMCIHPLLYMAVADSIRLC 281
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
70-345 2.95e-18

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 84.40  E-value: 2.95e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  70 TIMALYSIVC-VVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCKIVISID 147
Cdd:cd15073   1 NIVAAYLIVAgIISTISNGIVLVTFVKFRELRTPTNALIINLAVTDlGVSIIGYPFSAASDLHGSWKFGYAGCQWYAFLN 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 148 YYNMFTSIFTLCTMSVDRYIAVCHPvKALDFRTPRNAKIVNVCNWILSSA-IGLPVMFMATTKYRQGSIDCTLTFSHPTW 226
Cdd:cd15073  81 IFFGMASIGLLTVVAVDRYLTICRP-DLGRKMTTNTYTVMILLAWTNAFFwAAMPLVGWASYALDPTGATCTINWRKNDS 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 227 YWENLLkICVFIFAFIMPVLIITVCYGLMILRLKSV---RMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIK 303
Cdd:cd15073 160 SFVSYT-MSVIVVNFIVPLAVMFYCYYNVSRFVKKVlasDCLESVNIDWTDQNDVTKMSVIMIVMFLVAWSPYSIVCLWA 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 84370244 304 AL---ITIPettfqtvSWHFCIA--LGYTNSCLNPVLYAFLDENFKR 345
Cdd:cd15073 239 SFgepKKIP-------PWMAIIPplFAKSSTFYNPCIYVIANKKFRR 278
7tmA_CCRL2 cd15171
CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G ...
74-346 3.02e-18

CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine (CC-motif) receptor-like 2 (CCRL2) is a member of the atypical chemokine receptor family. CCRL2, like other atypical receptors, has an alteration in the conserved DRYLAIV motif in the third intracellular loop, which is essential for GPCR coupling and signaling. CCR2L is expressed in most hematopoietic cells and many lymphoid organs as well as in heart and lung. CCRL2 was initially reported to promote chemotaxis and calcium fluxes in responses to chemokines (CCL2, CCL5, CCL7, and CCL8); however, these results are still controversial. More recently, chemerin, a chemotactic agonist of CMKLR1 (chemokine-like receptor-1) and GPR1, was identified as a novel non-signaling ligand for both human and mouse CCRL2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C).


Pssm-ID: 320299  Cd Length: 279  Bit Score: 84.50  E-value: 3.02e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  74 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPfGTILCKIVISIDYYNMFT 153
Cdd:cd15171   6 LCSAVFLVGLLDNGLVVFILVKYKGLKHVENIYFLNLAVSNLCFLLTLPFWAHAAWHGGSL-GNPTCKVLVALSSVGLHS 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 154 SIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIV-NVCNWILSSAIGLP-VMFMATTKYRQGSiDCtlTFSHPTW----- 226
Cdd:cd15171  85 EALFNVLLTVQASRVFFHGRLASSARRVAPCGIIaSVLAWLTAFLVTLPeFVFYKPQMDSQKS-KC--AFSRPHFlpaee 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 227 -YWENLLKICVFIFAFIMPVLIITVCYglmilrlksVRMLSGSKEKDRNlRRITRMVLVVVAVFIVCWTPIHIYVIIKA- 304
Cdd:cd15171 162 tFWKYFLTLKMNIVVLVFPLLVFIICC---------VQLRKTQRFRERQ-RDLSKLVFAIMVVFLLMWAPYNIALFLSAf 231
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 84370244 305 -----LITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRC 346
Cdd:cd15171 232 kehfsLRDCKSSYHLDASVQVTKLIATTHCCVNPLLYALLDPAFRRR 278
7tmA_NPFFR1 cd15981
neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G ...
71-347 3.29e-18

neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320647 [Multi-domain]  Cd Length: 299  Bit Score: 84.88  E-value: 3.29e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  71 IMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISIDYY 149
Cdd:cd15981   3 FILAYLFIFLLCMVGNGLVCFIVLKNRQMRTVTNMFILNLAVSDLLvGIFCMPTTLVDNLITGWPFDNAMCKMSGLVQGM 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 150 NMFTSIFTLCTMSVDRYIAVCHPvkaldFR---TPRNAKIVNVCNWILSSAIGLP-VMFMATTKYRQGSIDCTLTFSHPT 225
Cdd:cd15981  83 SVSASVFTLVAIAVERFRCIVHP-----FRqklTLRKAIVTIVIIWVLALIIMCPsAVTLTVTREEHHFMVDDYNNSYPL 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 226 WY-WEN--------LLKICVFIFAFIMPVLIITVCYGLMILRL-KSVRMLSGSKEKDRNLRRITR-------MVLVVVAV 288
Cdd:cd15981 158 YScWEAwpdtemrkIYTTVLFSHIYLAPLTLIVIMYARIAFKLfKSSAPIRGSQGEEEEGRRVSKrkikvinMLIIVALF 237
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 84370244 289 FIVCWTPIHIYVIIKALITIPETTFQTVSWH---FCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15981 238 FTLSWLPLWTLMLLTDYGHLSEDQLNLVTVYvfpFAHWLAFFNSSVNPIIYGYFNENFRRGF 299
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
69-348 3.76e-18

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 83.84  E-value: 3.76e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISID 147
Cdd:cd15334   1 ILISLTLSILALMTTAINSLVITAIIVTRKLHHPANYLICSLAVTDFLvAVLVMPFSIMYIVKETWIMGQVVCDIWLSVD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 148 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSiDCTLTFSHPTWy 227
Cdd:cd15334  81 ITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGIMIAVVWIISIFISMPPLFWRHQTTSRED-ECIIKHDHIVF- 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 228 wenllKICVFIFAFIMPVLIItvcyglMILRLKSVRMLSGSKEKDRNLRRItrmvlvvVAVFIVCWTPihiYVIIKALIT 307
Cdd:cd15334 159 -----TIYSTFGAFYIPLALI------LILYYKIYRAATRERKAATTLGLI-------LGAFVICWLP---FFVKEVIVN 217
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 84370244 308 IPETTFQTVSW-HFCIALGYTNSCLNPVLYAFLDENFKRCFR 348
Cdd:cd15334 218 TCDSCYISEEMsNFLTWLGYINSLINPLIYTIFNEDFKKAFQ 259
7tmA_GPER1 cd14989
G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G ...
74-344 4.04e-18

G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled estrogen receptor 1 (GPER1), also known as the G-protein coupled receptor 30 (GPR30), is a high affinity receptor for estrogen. This receptor is a member of the class A of seven-transmembrane GPCRs. Estrogen binding results in intracellular calcium mobilization and synthesis of phosphatidylinositol (3,4,5)-trisphosphate in the nucleus. GPR30 plays an important role in development of tamoxifen resistance in breast cancer cells. The distribution of GPR30 is well established in the rodent, with high expression observed in the hypothalamus, pituitary gland, adrenal medulla, kidney medulla and developing follicles of the ovary. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320120 [Multi-domain]  Cd Length: 276  Bit Score: 84.11  E-value: 4.04e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  74 LYSIVCV-VGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNyLMGTWPFGTILCKIVISIDYYNMF 152
Cdd:cd14989   5 LYTIFLFpIGFIGNILILVVNLSFREKMTIPDLYFVNLAVADLILVADSLIEVFN-LNEKYYDIAVLCTFMSLFLQINMY 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 153 TSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILS-SAIGLPVmfmaTTKYRQGSIDCTLTFSH-PTWYWen 230
Cdd:cd14989  84 SSIFFLTWMSFDRYIALAKVMKSSPLRTMQHARLSCGLIWMASiSATLLPF----TAVQAQHTGEVHFCFADvREIQW-- 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 231 lLKICVfifAFIMPVLIITVCYGLMilrlksVRMLSGSkEKDRNLR----RITRMVLVVVAVFIVCWTPIHIYVIIKAL- 305
Cdd:cd14989 158 -LEVTL---GFIIPFSIIGLCYSLI------VRVLVRA-QKHRRLRprrqKALRMILVVVLVFFICWLPENVFISIQLLq 226
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 84370244 306 -ITIPETTFQTVSWHFCIALG-------YTNSCLNPVLYAFLDENFK 344
Cdd:cd14989 227 gTQEPSESYDESFRHNHPLTGhivnlaaFSNSCLNPLIYSFLGETFR 273
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
71-336 6.38e-18

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 83.80  E-value: 6.38e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  71 IMALYSIVCVvglFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYY 149
Cdd:cd15958   6 LMALIVLLIV---AGNVLVIVAIGRTQRLQTLTNLFITSLACADlVMGLLVVPFGATLVVRGRWLYGSFFCELWTSVDVL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 150 NMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIG-LPVMFMATTKYRQGSIDCTLTFSHPTWYW 228
Cdd:cd15958  83 CVTASIETLCVIAIDRYLAITSPFRYQSLLTRARAKGIVCTVWAISALVSfLPIMMHWWRDEDDQALKCYEDPGCCDFVT 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 229 ENLLKICVFIFAFIMPVLIITVCYGLMIL--------------RLKSVRMLSGSKEKDRNLR-------RITRMVLVVVA 287
Cdd:cd15958 163 NRAYAIASSIISFYIPLLIMIFVYLRVYReakkqikkidkcegRFHNTLTGLGRKCKRRPSRilalreqKALKTLGIIMG 242
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 84370244 288 VFIVCWTPIHIYVIIKALIT--IPETTFQTVSWhfciaLGYTNSCLNPVLY 336
Cdd:cd15958 243 VFTLCWLPFFLVNVVNVFNRelVPDWLFVFFNW-----LGYANSAFNPIIY 288
7tmA_Pinopsin cd15084
non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...
67-347 7.32e-18

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320212 [Multi-domain]  Cd Length: 295  Bit Score: 83.76  E-value: 7.32e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  67 TAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALAT---STLPFqsVNYLMGTWPFGTILCKIV 143
Cdd:cd15084   9 TYLTVAVLMGMVVALASFVNGLVIVVSIKYKKLRSPLNYILVNLAVADLLVTlfgSSVSF--SNNIVGFFVFGKTMCEFE 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 144 ISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTpRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGsidcTLTFSH 223
Cdd:cd15084  87 GFMVSLTGIVGLWSLAILAFERYLVICKPMGDFRFQQ-RHAVSGCAFTWGWSLLWTSPPLFGWSSYVPEG----LRTSCG 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 224 PTWYW----ENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKE-KDRNLRRITRMVLVVVAVFIVCWTPIHI 298
Cdd:cd15084 162 PNWYTggtnNNSYILALFVTCFALPLSTIIFSYSNLLLTLRAVAAQQKESEtTQRAEKEVTRMVIAMVMAFLICWLPYAT 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 84370244 299 YVIIKAliTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15084 242 FAMVVA--TNKDVVIQPTLASLPSYFSKTATVYNPIIYVFMNKQFRSCL 288
7tmA_D2_dopamine_R cd15309
D2 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
74-347 7.71e-18

D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320435 [Multi-domain]  Cd Length: 254  Bit Score: 82.78  E-value: 7.71e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  74 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMF 152
Cdd:cd15309   6 LLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLvATLVMPWVVYLEVVGEWRFSRIHCDIFVTLDVMMCT 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 153 TSIFTLCTMSVDRYIAVCHP-VKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTkyrQGSIDCTLtfSHPTWYwenl 231
Cdd:cd15309  86 ASILNLCAISIDRYTAVAMPmLYNTRYSSKRRVTVMISVVWVLSFAISCPLLFGLNN---TDQNECII--ANPAFV---- 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 232 lkICVFIFAFIMPVLIITVCYGLMILRLKsvrmlsgsKEKdrnlrRITRMVLVVVAVFIVCWTPIHIYVIIKALIT--IP 309
Cdd:cd15309 157 --VYSSIVSFYVPFIVTLLVYVQIYIVLQ--------KEK-----KATQMLAIVLGVFIICWLPFFITHILNMHCDcnIP 221
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 84370244 310 ETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15309 222 PALYSAFTW-----LGYVNSAVNPIIYTTFNIEFRKAF 254
7tmA_P2Y12 cd15150
P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled ...
74-345 7.79e-18

P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y12 receptor (P2Y12R) is found predominantly on the surface of blood platelets and is activated by adenosine diphosphate (ADP). P2Y12R plays an important role in the regulation of blood clotting and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341326  Cd Length: 285  Bit Score: 83.33  E-value: 7.79e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  74 LYSIVCVVGLFGNFLVMYVIVRyTKMKTATNIYIFNLALADALATSTLPFQSV-NYLMGTWPFGTILCKIVISIDYYNMF 152
Cdd:cd15150   6 LYTVLFIVGLTMNGLAMRVFFQ-IPSKSNFIIFLKNTVISDLLMILTFPFKILsDAKLGSWPLRGFVCQVTSVIFYFTMY 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 153 TSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSI-DCTLTFSHPTWYWENL 231
Cdd:cd15150  85 ISILFLGLITIDRYQKTTRPFKTSNPKNLLGAKILSTVIWASMFALSLPNMILTNRQPTPKNVkKCSLLKSEFGLVWHEI 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 232 LK-ICVFIFAFIMpvLIITVCYGLMILRL-KSVRMLSGSKEKDRnlRRITRMVLVVVAVFIVCWTPIHiyviikaLITIP 309
Cdd:cd15150 165 VNyICQVIFWVNF--LIVIVCYTLITKELyKSYKRTRGVGKVSR--KKVNVKVFIIIAVFFICFVPFH-------FARIP 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 84370244 310 ETTFQTVSWHFCIA-------------LGYTNSCLNPVLYAFLDENFKR 345
Cdd:cd15150 234 YTLSQTRDVFDCTAkntlfyvkestlwLTSLNACLDPFIYFFLCKSFRN 282
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
73-347 8.35e-18

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 83.31  E-value: 8.35e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  73 ALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSV------NYLMGTWpfGTILCKIVISi 146
Cdd:cd15082  18 ALMFVVTSLSLAENFAVMLVTFRFKQLRQPLNYIIVNLSVADFLVSLTGGTISFltnargYFFLGVW--ACVLEGFAVT- 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 147 dyYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTpRNAKIVNVCNWILSSAIGLPVMfMATTKYRQGSIDCTltfSHPTW 226
Cdd:cd15082  95 --FFGIVALWSLAVLAFERFFVICRPLGNIRLQG-KHAALGLLFVWTFSFIWTIPPV-LGWSSYTVSKIGTT---CEPNW 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 227 YWENLLK----ICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNL-RRITRMVLVVVAVFIVCWTPIHIY-V 300
Cdd:cd15082 168 YSGNMHDhtyiITFFTTCFILPLGVIFVSYGKLLQKLRKVSNTQGRLGNARKPeRQVTRMVVVMIVAFMVCWTPYAAFsI 247
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 84370244 301 IIKALITIP-ETTFQTVSWHFcialGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15082 248 LVTAHPTIHlDPRLAAIPAFF----SKTAAVYNPIIYVFMNKQFRKCL 291
7tmA_NTSR cd15130
neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
69-347 1.28e-17

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320258 [Multi-domain]  Cd Length: 281  Bit Score: 82.69  E-value: 1.28e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNI---YIFNLALADALAT-STLPFQSVNYLM--GTWPFGTILCKI 142
Cdd:cd15130   1 VLVTAIYLALFVVGTVGNSVTLFTLARKKSLQSLQSTvryHLGSLALSDLLILlLAMPVELYNFIWvhHPWAFGDAGCRG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 143 VISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQ------GSID 216
Cdd:cd15130  81 YYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIPMLFTMGLQNESddgthpGGLV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 217 CTLTFSHPTwyWENLLKICVFIfAFIMPVLIITVCYGLMILRLKsvrmlsgskekdRNLRRITRMVLVVVAVFIVCWTPI 296
Cdd:cd15130 161 CTPIVDTAT--LKVVIQVNTFM-SFLFPMLVTSILNTVIANKLV------------QALRRGVLVLRAVVIAFVVCWLPY 225
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 84370244 297 HIYVIIKALI-----TIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15130 226 HVRRLMFCYIsdeqwTTFLFDFYHYFYMLTNALFYVSSAINPILYNLVSANFRQVF 281
7tmA_Parapinopsin cd15075
non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...
69-346 1.59e-17

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.


Pssm-ID: 320203 [Multi-domain]  Cd Length: 279  Bit Score: 82.52  E-value: 1.59e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADalatstlpfqsvnylMGTWPFGTILCKIVISIDY 148
Cdd:cd15075   1 TILSIIMAVFSIASVVLNATVIIVTLRHKQLRQPLNYALVNLAVAD---------------LGTTVFGGLLSVVTNAVGY 65
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 149 YNM-------------FTSIFTLCT---MSVDRYIAVCHPVKALDFrTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQ 212
Cdd:cd15075  66 FNLgrvgcvlegfavaFFGIAALCTvavIAVDRLFVVCKPLGTLTF-QTRHALAGIASSWLWSLIWNTPPLFGWGSYQLE 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 213 GsidcTLTFSHPTWYWENLLK----ICVFIFAFIMPVLIITVCYGLMILRLKSVRML----SGSKEKDRNlrRITRMVLV 284
Cdd:cd15075 145 G----VMTSCAPDWYSRDPVNvsyiLCYFSFCFAIPFAIILVSYGYLLWTLRQVAKLgvaeGGSTAKAEV--QVARMVVV 218
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 84370244 285 VVAVFIVCWTPIHIYVIIkaLITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRC 346
Cdd:cd15075 219 MVMAFLLCWLPYAAFALT--VVSKPDVYINPLIATVPMYLAKSSTVYNPIIYIFMNKQFRDC 278
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
72-255 1.72e-17

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 81.81  E-value: 1.72e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  72 MALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATS-TLPFQSVNYLMGTWPFGTILCKIVISIDYYN 150
Cdd:cd15215   3 SVLIVIFLCASLFGNIVLLLVFQRKPQLLQVANRFIFNLLVADLLQTVlVMPWVIATSVPLFWPLDSHLCTALVVLMHLF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 151 MFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMF-MATTKYRQGSIDCTLTFSHPTWYwe 229
Cdd:cd15215  83 AFAGVNTIVVVSVDRYLAIIHPLSYPTKMTPRRGYLLIYGTWIVSVLQSTPPLYgWGQAAFDERNALCSVIWGSSYSY-- 160
                       170       180
                ....*....|....*....|....*.
gi 84370244 230 nllKICVFIFAFIMPVLIITVCYGLM 255
Cdd:cd15215 161 ---TILSVVSSFVLPVIIMLACYSMV 183
7tmA_V2R cd15388
vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
72-346 1.89e-17

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320510 [Multi-domain]  Cd Length: 295  Bit Score: 82.51  E-value: 1.89e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  72 MALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATStlpFQSVNYLM----GTWPFGTILCKIVISID 147
Cdd:cd15388   4 IAVLAIIFACALLSNSLVLLVLWRRRKQLARMHVFMLHLCIADLVVAF---FQVLPQLVwditDRFRGPDVLCRLVKYLQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 148 YYNMFTSIFTLCTMSVDRYIAVCHPVKAldFRTPRNAKIVNVC-NWILSSAIGLPVMFM-ATTKYRQGSIDCTLTFSHP- 224
Cdd:cd15388  81 VVGMFASSYMIVAMTFDRHQAICRPMVT--FQKGRARWNGPVCvAWAISLILSLPQVFIfSKVEVAPGVYECWACFIEPw 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 225 ------TWywenllkicVFIFAFIMPVLIITVCYGL------MILRLKSVRMLSGSKEKDRNLRRIT------------- 279
Cdd:cd15388 159 glkayvTW---------ITLVVFVLPTLIITVCQVLifkeihINIYLKSQIIVAVVKKKQLLSSRASsvaevskamiktv 229
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 84370244 280 RMVLVVVAVFIVCWTPIHIYVIIKALitIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRC 346
Cdd:cd15388 230 KMTLVIVLVYVLCWAPFFLVQLWSVW--DPKAPTEGATFTILMLLASLNSCTNPWIYMAFSSSVSKE 294
7tmA_TAAR6_8_9 cd15316
trace amine-associated receptors 6, 8, and 9, member of the class A family of ...
69-345 1.94e-17

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320439 [Multi-domain]  Cd Length: 290  Bit Score: 82.21  E-value: 1.94e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST-LPFQSVNYLMGTWPFGTILCKIVISID 147
Cdd:cd15316   1 VILYIVLGFGAVLAVFGNLLVMISILHFKQLHSPTNFLIASLACADFLVGVTvMPFSTVRSVESCWYFGESFCTFHTCCD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 148 YYNMFTSIFTLCTMSVDRYIAVCHP-VKALDFRTPRNAKIVNVcNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTW 226
Cdd:cd15316  81 VSFCYASLFHLCFISVDRYIAVTDPlVYPTKFTVSVSGICISV-SWIFSLTYSFSVFYTGVNDDGLEELVNALNCVGGCQ 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 227 YWENLLKICVFIFAFIMPVLIITVCYGLMILRLK-SVRML---------SGSKEKDRNLRR---ITRMVLVVVAVFIVCW 293
Cdd:cd15316 160 IILNQNWVLVDFLLFFIPTFAMIILYGKIFLVAKqQARKIemtsskaesSSESYKDRVARRerkAAKTLGITVIAFLVSW 239
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 84370244 294 TPIHIYVIIKALIT--IPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKR 345
Cdd:cd15316 240 LPYLIDVLIDAFMNfiTPPYIYEICCW-----CAYYNSAMNPLIYALFYPWFRK 288
7tmA_GPR182 cd14988
G protein-coupled receptor 182, member of the class A family of seven-transmembrane G ...
69-344 2.33e-17

G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR182 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. When GPR182 gene was first cloned, it was proposed to encode an adrenomedullin receptor. However when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320119 [Multi-domain]  Cd Length: 278  Bit Score: 81.74  E-value: 2.33e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMG-TWPFGTILCKIVISID 147
Cdd:cd14988   1 VVLFILYLVIFVVGLVENVLVIWVNWHRWGSKNLVNLYILNMAIADLGVVLTLPVWMLEVMLDyTWLWGSFLCKFTHYFY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 148 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLP-VMFMATTKYRQ-GSIDCTLTFSHPT 225
Cdd:cd14988  81 FANMYSSIFFLTCLSVDRYLTLTSSSPFWQQHQHRIRRALCAGIWVLSAIIPLPeVVHMQLLDGVEpMCLFLAPFETYDE 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 226 WYWEnlLKICVFIFAFIMPVLIITVCYGLMILRLKSvrmlSGSKEKdrnlRRITRMVLVVVAVFIVCWTPIHIYVIIKAL 305
Cdd:cd14988 161 WALA--VSLLTLIIGFLIPFSIIAVFNVLTARYIRT----AGRPES----RRHCLLIYAYILVFVVCWLPYHVTLLLLTL 230
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 84370244 306 ITIPeTTFQTVSWHF---------CIALgyTNSCLNPVLYAFLDENFK 344
Cdd:cd14988 231 HGSH-ISLHCNLVHFlyffydvidCFSL--LHCVANPILYNFLSKSFR 275
7tmA_PAR3 cd15371
protease-activated receptor 3, member of the class A family of seven-transmembrane G ...
71-336 2.51e-17

protease-activated receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320493 [Multi-domain]  Cd Length: 274  Bit Score: 81.77  E-value: 2.51e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  71 IMALYSIVCVVGLFGNFLVMYVIVRYTKmKTATNIYIFNLALADALATSTLPFQSVNYLMGT-WPFGTILCKIVISIDYY 149
Cdd:cd15371   3 IPAVYIIVVVLGVPSNAIILWMLFFRLR-SVCTAIFYANLAISDLLFCITLPFKIVYHLNGNnWVFGETMCRIITITFYG 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 150 NMFTSIFTLCTMSVDRYIAVCHPVKALDFrtPRNAKIVNVCN--WILSSAIGLPVMFMATTKY-RQGSI--------DCT 218
Cdd:cd15371  82 NMYCSILLLTCISINRYLAIVHPFIYRSL--PKKTYAVLICAlvWTIVFLYMLPFFILKQTYYlKELNIttchdvlpECE 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 219 LTFSHPTWYWenllkICVFIFAFIMPVLIITVCYGLMIlrlksvRMLSGSKEKDRNLRRITRMvlvVVAVFIVCWTPIHI 298
Cdd:cd15371 160 QNSNFQFYYF-----ISMAVFGFLIPLVITIFCYISII------RTLNAYEHKWFWYVKITAL---VLIIFTICFAPSNV 225
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 84370244 299 YVIIKAlITIPETTFQTVSWHFCIA--LGYTNSCLNPVLY 336
Cdd:cd15371 226 ILIIHH-FNYYYFNNDNLYSIYLIAlcLGSLNSCLDPFLY 264
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
71-350 5.96e-17

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 80.65  E-value: 5.96e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  71 IMALYSIVCVVGlfGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLM-GTWPFGTILCKIVISIDY 148
Cdd:cd15306   5 LLILMVIIPTIG--GNILVILAVSLEKKLQYATNYFLMSLAVADLLvGLFVMPIALLTILFeAMWPLPLVLCPIWLFLDV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 149 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYR--QGSIDCTLTFshptw 226
Cdd:cd15306  83 LFSTASIMHLCAISLDRYIAIKKPIQASQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVdnPNNITCVLTK----- 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 227 ywENLLKICVF--IFAFIMPVLIITVCYGLMILRLKsvrmlsgsKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKA 304
Cdd:cd15306 158 --ERFGDFILFgsLAAFFTPLAIMIVTYFLTIHALR--------KQTITNEQRASKVLGIVFFLFLLMWCPFFITNITSV 227
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 84370244 305 LI-TIPETTFQTVSWHFcIALGYTNSCLNPVLYAFLDENFKRCFREF 350
Cdd:cd15306 228 LCdSCNQTTLQMLMEIF-VWIGYVSSGVNPLVYTLFNKTFRDAFGRY 273
7tmA_OXER1 cd15200
oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G ...
70-345 8.71e-17

oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; OXER1, also called GPR170, is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. OXER1 is a member of the class A family of seven-transmembrane G-protein coupled receptors and appears to be coupled to the G(i/o) protein. The receptor is expressed in various tissues except brain. Phylogenetic analysis showed that GPR31 and OXER1 are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). OXER1, like GPR31, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike GPR31, does cause increase in the cytosolic calcium level.


Pssm-ID: 320328 [Multi-domain]  Cd Length: 276  Bit Score: 80.20  E-value: 8.71e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  70 TIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMG-TWPFGTILCKIVISIDY 148
Cdd:cd15200   2 FLAPVLGIEFVLGLVGNGIALFIFCFHRRPWKSNTMYLLSLVVADFFLIINLPFRIDYYLRNeVWRFGATACQVNLFMLS 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 149 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMfmaTTKYRQGSIDCtLTFSHPT--- 225
Cdd:cd15200  82 MNRTASIVFLTAIALNRYLKVVHPHHQLSKASVGCAAKVAAGLWILILLLNIHLL---LLDHVQSNSTC-LSYDHGTdps 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 226 --WYWENLLkicvFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKekdrnLRRITRMVLVVVAVFIVCWTPIHIY---V 300
Cdd:cd15200 158 asDRWHRIL----FFLEFFLPLGIILFCIFSIILTLKQRKLAKQAG-----PQRAVKVLAVIVLVYTVCFLPSILFalaS 228
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 84370244 301 IIKALITIPET-TFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKR 345
Cdd:cd15200 229 LVAFKVSQCRSlDLCTQLFHGSLAFTYLNSALDPVLYCFSSPSFLN 274
7tmA_Histamine_H4R cd15295
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...
69-351 2.06e-16

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320422 [Multi-domain]  Cd Length: 267  Bit Score: 79.10  E-value: 2.06e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATS-TLPFQSVNYLMGTWPFGTILCKIVISID 147
Cdd:cd15295   1 VVLLFLMSLLALVIVLGNALVIIAFVVDKNLRHRSNYFFLNLAISDFFVGAiSIPLYIPYTLTNRWDFGRGLCVFWLVID 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 148 YYNMFTSIFTLCTMSVDRYIAVCHpvkALDFRTPRNA--KIVN--VCNWILSSAIGLPvMFMATTKYRQGSIDCTltfsh 223
Cdd:cd15295  81 YLLCTASVYNIVLISYDRYQSVSN---AVSYRNQQTAtlRIVTqmVAVWVLAFLVHGP-AILVSDSWKTEDGECE----- 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 224 PTWYWENLLKICVFIFAFIMPVLIITVcYGLMILRlksvrmlsgSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIK 303
Cdd:cd15295 152 PEFFSNWYILAITSVLEFLVPVILVAY-FNTQIYW---------SLWKRLRDRKLAKSLAIILGTFAICWAPYSLFTIIR 221
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 84370244 304 ALItipETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFRE-FC 351
Cdd:cd15295 222 AAC---EKHRGSPWYNFAFWLQWFNSFINPFLYPLCHKRFRKAFLKiFC 267
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
77-347 2.46e-16

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 79.21  E-value: 2.46e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  77 IVCVVGLFGNFLVMYVIVRYTKMKTATNIY-IFNLALADAL--------ATSTLPFQSVNYLMGTWPFGTILCKIVISID 147
Cdd:cd14980   9 IIGILALIGNILVIIWHISSKKKKKKVPKLlIINLAIADFLmgiylliiAIADQYYRGRYAQYSEEWLRSPPCLLACFLV 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 148 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFrTPRNAKIVNVCNWILSSA-IGLPVMFmattKYRQGSIDCTLTFSH--- 223
Cdd:cd14980  89 SLSSLMSVLMMLLITLDRYICIVYPFSNKRL-SYKSAKIILILGWLFSIIfAAIPILY----SINQPGDNRLYGYSSicm 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 224 PTWYWENLLKICVFIFAFIMPV--LIITVCYGLMILRLKSVRMLSGSKEKDRNlRRITRMVLVVVAVFIVCWTPIhIYVI 301
Cdd:cd14980 164 PSNVSNPYYRGWLIAYLLLTFIawIIICILYILIFISVRKSRKSARRSSSKRD-KRIAIRLALILITDLICWLPY-YIVI 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 84370244 302 IKALITIPETTFQTVSWHFCIALGyTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd14980 242 FSGLLTSTEIDIHVLQFIAILALP-LNSAINPYLYTLTTPTFKRDF 286
7tmA_SWS2_opsin cd15077
short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G ...
86-346 3.32e-16

short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 2 (SWS2), which mediates visual transduction in response to light at short wavelengths (violet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320205 [Multi-domain]  Cd Length: 280  Bit Score: 78.72  E-value: 3.32e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  86 NFLVMYVIVRYTKMKTATNIYIFNLALADALAT---STLPFQSVNYLMGTWpfGTILCKIVISIDYYNMFTSIFTLCTMS 162
Cdd:cd15077  18 NVLTIICTIKYKKLRSHLNYILVNLAVANLIVVcfgSTTAFYSFSQMYFVL--GPLACKIEGFTATLGGMVSLWSLAVVA 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 163 VDRYIAVCHPVKALDFRTPrNAKIVNVCNWILSSAIGLPVMFmATTKYRQGSIDCTLTfshPTWY-----WEN-LLKICV 236
Cdd:cd15077  96 FERFLVICKPLGNFTFRGT-HAIIGCIATWVFGLAASLPPLF-GWSRYIPEGLQCSCG---PDWYttnnkWNNeSYVMFL 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 237 FIFAFIMPVLIITVCYGLMILRLKSV-RMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIikALITIPETTFQT 315
Cdd:cd15077 171 FCFCFGVPLSIIVFSYGRLLLTLRAVaKQQEQSASTQKAEREVTKMVVVMVLGFLVCWLPYASFAL--WVVTNRGEPFDL 248
                       250       260       270
                ....*....|....*....|....*....|.
gi 84370244 316 VSWHFCIALGYTNSCLNPVLYAFLDENFKRC 346
Cdd:cd15077 249 RLASIPSVFSKASTVYNPVIYVFMNKQFRSC 279
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
72-338 7.97e-16

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 77.94  E-value: 7.97e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  72 MALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYN 150
Cdd:cd15385   4 IAVLAVIFAVAVIGNSSVLLALYKTKKKASRMHLFIKHLSLADlVVAFFQVLPQLCWDITYRFYGPDFLCRIVKHLQVLG 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 151 MFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRnAKIVNVCNWILSSAIGLPVMFMATTKYRQ---GSIDCTLTFSHPTWY 227
Cdd:cd15385  84 MFASTYMLVMMTADRYIAICHPLKTLQQPTKR-SYLMIGSAWALSFILSTPQYFIFSLSEIEngsGVYDCWANFIVPWGI 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 228 WENLLKICVFIfaFIMPVLIITVCYGLMI------LRLKSVRMLSGSKEKDRNLR--------------RITRMVLVVVA 287
Cdd:cd15385 163 KAYITWITISI--FVVPVIILLTCYGFICyniwrnIKCKTRRGLSDNALKNILLAvcvssvktisrakiRTVKMTFVIVL 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 84370244 288 VFIVCWTPIHIYVII-----KALITIPETTFQTVSwhfcIALGYTNSCLNPVLYAF 338
Cdd:cd15385 241 AYIVCWAPFFTIQMWsvwdqNFPWDESENTAVTIT----ALLASLNSCCNPWIYMF 292
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
80-346 1.04e-15

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 77.20  E-value: 1.04e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  80 VVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD---ALATSTLpFQSVNYlMGTWPFGTILCKIV-ISIDYYNMfTSI 155
Cdd:cd15085  12 TFSIFNNVLVIAVTLKNPQLRNPINIFILNLSFSDlmmALCGTTI-VTVTNY-EGYFYLGDAFCIFQgFAVNYFGI-VSL 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 156 FTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVnVCNWILSSAIGLPVMFMATTKYRQG-SIDCTLTFSHPTWYWENLLkI 234
Cdd:cd15085  89 WSLTLLAYERYNVVCKPMGGLKLSTKRGYQGL-LFIWLFCLFWAVAPLFGWSSYGPEGvQTSCSIGWEERSWSNYSYL-I 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 235 CVFIFAFIMPVLIITVCYGLMILRL----KSVRMLSGsKEKDRNLRRITRMVLVVVAVFIVCWTPihiYVIIKALITI-P 309
Cdd:cd15085 167 LYFLMCFVIPVAIIGFSYGNVLRSLhklnKKIEQQGG-KNCPEEEERAVIMVLAMVIAFLICWLP---YTVFALIVVVnP 242
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 84370244 310 ETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRC 346
Cdd:cd15085 243 ELSISPLAATMPTYFAKTSPVYNPIIYIFLNKQFRES 279
7tmA_MWS_opsin cd15080
medium wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
80-346 1.25e-15

medium wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Medium Wave-Sensitive opsin, which mediates visual transduction in response to light at medium wavelengths (green). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 381742 [Multi-domain]  Cd Length: 280  Bit Score: 76.79  E-value: 1.25e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  80 VVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALA-----TSTLpFQSVNylmGTWPFGTILCKIVISIDYYNMFTS 154
Cdd:cd15080  12 LLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMvfggfTTTM-YTSMH---GYFVFGPTGCNLEGFFATLGGEIA 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 155 IFTLCTMSVDRYIAVCHPVKalDFRTPRNAKIVNVC-NWILSSAIGLPVMFmATTKYRQGSIDCTLTFS----HPTWYWE 229
Cdd:cd15080  88 LWSLVVLAIERYVVVCKPMS--NFRFGENHAIMGVAfTWVMALACAAPPLV-GWSRYIPEGMQCSCGIDyytlKPEVNNE 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 230 NLLkICVFIFAFIMPVLIITVCYGLMILRLK-SVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPihiYVIIKALITI 308
Cdd:cd15080 165 SFV-IYMFVVHFTIPLIVIFFCYGRLVCTVKeAAAQQQESATTQKAEKEVTRMVIIMVIAFLICWVP---YASVAFYIFT 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 84370244 309 PE-----TTFQTVSWHFcialGYTNSCLNPVLYAFLDENFKRC 346
Cdd:cd15080 241 HQgsdfgPIFMTIPAFF----AKSSAVYNPVIYILMNKQFRNC 279
7tmA_GPR87 cd15969
G protein-coupled receptor 87, member of the class A family of seven-transmembrane G ...
69-345 1.91e-15

G protein-coupled receptor 87, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR87 acts as one of multiple receptors for lysophosphatidic acid (LPA). This orphan receptor has been shown to be over-expressed in several malignant tumors including lung squamous cell carcinoma and regulated by p53. GPR87 is phylogenetically closely related to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase.


Pssm-ID: 320635 [Multi-domain]  Cd Length: 283  Bit Score: 76.37  E-value: 1.91e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYvIVRYTKMKTATNIYIFNLALADALATSTLPFQSVN-YLMGTWPFGTILCKIVISID 147
Cdd:cd15969   1 IVFPVLYLIIFIGSILLNGLAVW-IFFHIRNKTSFIFYLKNIVIADLLMTLTFPFKIIQdSGLGPWNFNFFLCRYTSVLF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 148 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLP-VMFMATTKYRQGSIDCTLTFSHPTW 226
Cdd:cd15969  80 YASMYTSIVFLGLISLDRYLKVVKPFGDSRMYSITFTKVLSACVWLIMAFLSLPnIILTNGQPTEDNIHDCSKLKSPLGV 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 227 YWENLLK-ICVFIFAFIMPVLIitVCYgLMILRL--KSVRMLSGSKEKDRNLRRITRmvlVVVAVFIVCWTPIH---IYV 300
Cdd:cd15969 160 KWHTAVSyINICIFVAVLVILI--VCY-ISISRYiyKSSKQFISSSSRTRKHNQSIR---VVVAVFFVCFLPYHlcrIPF 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 84370244 301 IIKALITIPETTFQTVSWhFC----IALGYTNSCLNPVLYAFLDENFKR 345
Cdd:cd15969 234 TFSQLDKILDCTIKTILY-YCkeatLFLSACNVCLDPIIYFFMCRSFSQ 281
7tmA_GPR171 cd15167
orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G ...
74-344 2.14e-15

orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR171 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. A recent study has been reported that the peptide LENSSPQAPARRLLPP (BigLEN) activates GPR17 to regulate body weight in mice; however the biological role of the receptor remains unknown. GPR171 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320295 [Multi-domain]  Cd Length: 282  Bit Score: 76.34  E-value: 2.14e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  74 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYL-MGTWPFGTILCKIVISIDYYNMF 152
Cdd:cd15167   6 FYYLIFLIGFIGSCFALWAFIQKRSSRKCINIYLINLLTADFLLTLALPVKIAVDLgIAPWKLKIFHCQVTACLIYINMY 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 153 TSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQ----GSIDCTLTFSHptwYW 228
Cdd:cd15167  86 LSIIFLGFVSIDRYLQLTHSSKLYRIQEPGFAKMISAVVWTLVLFIMVPNMAIPIKTIEEkpgvGCADFKTEFGR---HW 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 229 ENLLK-ICVFIFAFIMPVLIITVCygLMILRLKSVRmlsgSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIyviikalIT 307
Cdd:cd15167 163 HVLTNfICMAIFLNFSAIILISNF--LVIRKLYRNK----DSEEYRNARQALVNILLVTAGYVICFVPYHI-------VR 229
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 84370244 308 IPETTFQTVSWHFC-------------IALGYTNSCLNPVLYAFLDENFK 344
Cdd:cd15167 230 IPYTLSQSEVITDCslkrslflakestLLLAVLNLCFDPILYFHLSKAFR 279
7tmA_FFAR2_FFAR3 cd15170
free fatty acid receptors 2, 3, and similar proteins, member of the class A family of ...
69-252 2.75e-15

free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes free fatty acid receptor 2 (FFAR2), FFAR3, and similar proteins. They are a member of the class A G-protein coupled receptors that bind free fatty acids. The FFAR subfamily is composed of three receptors, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR2 and FFAR3 are cell-surface receptors for short chain FFAs (SCFAs) with different ligand affinities, whereas FFAR1 is a receptor for medium- and long-chain FFAs. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), thus suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320298  Cd Length: 278  Bit Score: 75.76  E-value: 2.75e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMK-TATNIYIFNLALADALATSTLPFQSVNYLMG-TWPFGTILCKIVISI 146
Cdd:cd15170   1 WLVLAVYIITFLIGLPANLLAFYTFIRKVRRKpTPIDILLLNLTVSDLIFLLFLPFKMAEAASGmIWPLPYFLCPLSSFI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 147 DYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSA---IGLPVMFMATTKYRQG--SIDCTLTF 221
Cdd:cd15170  81 FFSTIYISTLFLTAISVERYLGVAFPIKYKLRRRPLYAVIASVFFWVLAFShcsIVYIVEYHIDSENTSVtnNSRCYDNF 160
                       170       180       190
                ....*....|....*....|....*....|....*..
gi 84370244 222 ShptwywENLLKIC------VFIFAFIMPVLIITVCY 252
Cdd:cd15170 161 T------PEQLKILlpvrleLFLVLFCIPFLITCFCY 191
7tmA_P2Y14 cd15149
P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled ...
71-344 4.85e-15

P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y14 receptor is activated by UDP-sugars and belongs to the G(i) class of the P2Y family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14). P2Y14 receptor has been reported to be involved in a diverse set of physiological responses in many epithelia as well as in immune and inflammatory cells.


Pssm-ID: 320277 [Multi-domain]  Cd Length: 284  Bit Score: 75.27  E-value: 4.85e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  71 IMALYSIVCVVGLFGNFLVMYVIVrYTKMKTATNIYIFNLALADALATSTLPFQSV-NYLMGTWPFGTILCKIVISIDYY 149
Cdd:cd15149   3 IPVFYSLVFIVGILLNGVNFWIFF-YVPSNKSFIVYLKNIVFADLLMSLTFPFKILsDVELGPWQLNVIVCRYSAVIFYL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 150 NMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQ-GSIDCTLTFSHPTWYW 228
Cdd:cd15149  82 NMYVGIIFFGLIGFDRYYKIVKPLHTSFVQNVGYSKALSVVVWMLMAVLSVPNIILTNQSFHEaNYTKCARLKSELGIQW 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 229 ENLLK-ICVFIFAFIMPVLII---TVCYGLMILRLKSVRMLSGSKEKdrnlrrITRMVLVVVAVFIVCWTPIHIyviika 304
Cdd:cd15149 162 HKASNyICVSIFWVVFLLLIIfyvAISRKIYKSNQKFRRNSTNMKAK------SSRNIFSILFVFFVCFVPYHA------ 229
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 84370244 305 lITIPETTFQTVSWHFC-------------IALGYTNSCLNPVLYAFLDENFK 344
Cdd:cd15149 230 -LRIPYTLSQTGADYSCqsktilyymkeftLLLSAANVCLDPIIYFFLCQPFR 281
7tmA_NTSR2 cd15356
neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...
73-347 6.61e-15

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320478 [Multi-domain]  Cd Length: 285  Bit Score: 74.90  E-value: 6.61e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  73 ALYSIVCVVGLFGNFLVMYVIVRYT---KMKTATNIYIFNLALADALA-TSTLPFQSVNYLMGTWP--FGTILCKIVISI 146
Cdd:cd15356   5 AVYALIWALGAAGNALTIHLVLKKRslrGLQGTVHYHLVSLALSDLLIlLISVPIELYNFVWFHYPwvFGDLVCRGYYFV 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 147 DYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSID---------C 217
Cdd:cd15356  85 RDICSYATVLNIASLSAERYLAICQPLRAKRLLSKRRTKWLLALIWASSLGFALPMAFIMGQKYELETADgepepssrvC 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 218 TLTFSHPTwyWENLLKICVFIfAFIMPVLIITVCYGLMILRLKSvrmlsgskekdRNLRRITRMVLVVVAVFIVCWTPIH 297
Cdd:cd15356 165 TVLVSRAT--LKVFIQVNAFV-SFVLPLALIAFLNGVTVSHLRI-----------QSLQHSVQVLRAIVIAYVICWLPYH 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 84370244 298 IYVIIKALI-----TIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15356 231 ARRLMFCYVpddawTDSLYNFYHYFYMLTNTLFYVSSAVNPLLYNVVSSSFRKLF 285
7tmA_tmt_opsin cd15086
teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G ...
77-347 8.77e-15

teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G protein-coupled receptors; Teleost multiple tissue (tmt) opsins are homologs of encephalopsin. Mouse encephalopsin (or panopsin) is highly expressed in the brain and testes, whereas the teleost homologs are localized to multiple tissues. The exact functions of the encephalopsins and tmt-opsins are unknown. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Tmt opsins belong to the class A of the G protein-coupled receptors and show strong homology to the vertebrate visual opsins.


Pssm-ID: 320214 [Multi-domain]  Cd Length: 276  Bit Score: 74.39  E-value: 8.77e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  77 IVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALA-TSTLPFQSVNYLMGTWPFGTILCKivisidYYNMFTSI 155
Cdd:cd15086   9 FILTFGFLNNLLVLVLFCKYKVLRSPINLLLLNISLSDLLVcVLGTPFSFAASTQGRWLIGEHGCR------WYGFANSL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 156 F------TLCTMSVDRYIAVCHPVKAlDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQG-----SIDCTLTFSHP 224
Cdd:cd15086  83 FgivsliSLAVLSYERYCTLLRPTEA-DVSDYRKAWLGVGGSWLYSLLWTLPPLLGWSSYGPEGpgttcSVQWTSRSANS 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 225 TWYwenllKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNlRRITRMVLVVVAVFIVCWTPihiYVIIKA 304
Cdd:cd15086 162 ISY-----IICLFIFCLLLPFLVMVYCYGRLLYAIKQVGKINKSTARKRE-QHVLLMVVTMVICYLLCWLP---YGVMAL 232
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 84370244 305 LITIPETTFQTVSWHFCIA-LGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15086 233 LATFGKPGLVTPVASIVPSiLAKSSTVVNPIIYVFMNKQFYRCF 276
7tmA_GPR19 cd15008
G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...
74-345 8.98e-15

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320137 [Multi-domain]  Cd Length: 275  Bit Score: 74.10  E-value: 8.98e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  74 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMF 152
Cdd:cd15008   5 VFGVLWLVSVFGNSLVCLVIHRSRRTQSTTNYFVVSMACADLLlSVASAPFVLLQFTSGRWTLGSAMCKLVRYFQYLTPG 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 153 TSIFTLCTMSVDRYIAVCHPvkaLDFRTPR-NAKIVNVCNWILSSAIGLPVMFMattkYRQGSIDCTLTFSHPTWYwENL 231
Cdd:cd15008  85 VQIYVLLSICVDRFYTIVYP---LSFKVSReKAKKMIAASWLFDAAFVSPALFF----YGSNWGPHCNFFLPDSWD-GAA 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 232 LKICVFIFAFIMPVLIITVCYGlmilrlKSVRMLSGSKEKDRNLRRIT-----------RMVLVVVAVFIVCWTPIHIYV 300
Cdd:cd15008 157 YAIIHLLVGFLVPSILIILFYQ------KVIKYIWRIGTDGRTVRRTMnivprtkvktiKMFLMLNSMFLLSWLPFYVVQ 230
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 84370244 301 IIKALITIPETT---FQTVSWhfciaLGYTNSCLNPVLYAFLDENFKR 345
Cdd:cd15008 231 LWHPRESDYRQSslvFLAVTW-----ISFSSSASKPTLYSVYNANFRR 273
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
72-338 1.57e-14

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 74.08  E-value: 1.57e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  72 MALYSIVCVVGLFGNFLVMYVIvrYTKMKTATNIYIF--NLALADALATStlpFQSVNYLMGTWPF----GTILCKIVIS 145
Cdd:cd15387   4 VTVLALILFLALTGNICVLLAI--HTTRHKHSRMYFFmkHLSIADLVVAV---FQVLPQLIWDITFrfygPDFLCRLVKY 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 146 IDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVnvcNWILSSAIGLP-VMFMATTKYRQGSIDCTLTFSHP 224
Cdd:cd15387  79 LQVVGMFASTYMLLLMSIDRCLAICQPLRSLHRRSDRVYVLF---SWLLSLVFSIPqVHIFSLREVGNGVYDCWADFIQP 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 225 -------TWywenllkicVFIFAFIMPVLIITVCYGL-----------------------------MILRLKSVRMLSGS 268
Cdd:cd15387 156 wgpkayiTW---------ITLSVYIIPVLILSVCYGLisfkiwqnvklktrretktplssaasggaALARVSSVKLISKA 226
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 269 KekdrnlRRITRMVLVVVAVFIVCWTPihIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAF 338
Cdd:cd15387 227 K------IRTVKMTFVIVLAYIVCWTP--FFFVQMWSVWDPNAPKEASPFIIAMLLASLNSCCNPWIYMF 288
7tmA_Histamine_H3R cd15296
histamine receptor subtypes H3R and H3R-like, member of the class A family of ...
69-347 1.79e-14

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320423 [Multi-domain]  Cd Length: 271  Bit Score: 73.29  E-value: 1.79e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATS-TLPFQSVNYLMGTWPFGTILCKIVISID 147
Cdd:cd15296   1 VILAVLMALLVVATVLGNALVILAFVVDSSLRTQGNFFFLNLAISDFLVGGfCIPLYIPYVLTGRWKFGRGLCKLWLVVD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 148 YYNMFTSIFTLCTMSVDRYIAVchpVKALDFRT----PRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSI---DCTLT 220
Cdd:cd15296  81 YLLCTASVFNIVLISYDRFLSV---TRAVSYRAqkgmTRQAVLKMVLVWVLAFLLYGPAIISWEYIAGGSIIpegECYAE 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 221 FSHpTWYWenllKICVFIFAFIMPVLIITVcYGLMILRLKSVRMLSGSKEKdrnlrRITRMVLVVVAVFIVCWTPIHIYV 300
Cdd:cd15296 158 FFY-NWYF----LMTASTLEFFTPFISVTY-FNLSIYLNIQKRRFRLSRDK-----KVAKSLAIIVCVFGLCWAPYTLLM 226
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 84370244 301 IIKALI---TIPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15296 227 IIRAAChghCVPDYWYETSFW-----LLWVNSAINPVLYPLCHMSFRRAF 271
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
70-347 2.47e-14

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 73.43  E-value: 2.47e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  70 TIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTIL---CKIVIS 145
Cdd:cd15069   2 TYVALELIIAALSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADvAVGLFAIPFAITISLGFCTDFHSCLflaCFVLVL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 146 IDyynmfTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLpVMFMATTKYRQGSIDCTLTFSHPT 225
Cdd:cd15069  82 TQ-----SSIFSLLAVAVDRYLAIKVPLRYKSLVTGKRARGVIAVLWVLAFGIGL-TPFLGWNKAMSATNNSTNPADHGT 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 226 WY--------WENLLKICVFIF-----AFIMPVLIITVCYGLMIL----RLKSVRMLSGSKEKDRNLRRITRMVLVVVAV 288
Cdd:cd15069 156 NHscclisclFENVVPMSYMVYfnffgCVLPPLLIMLVIYIKIFLvacrQLQRTELMDHSRTTLQREIHAAKSLAIIVGI 235
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 84370244 289 FIVCWTPIHIYVIIKALitIPETTFQTVSW--HFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15069 236 FALCWLPVHILNCITLF--QPEFSKSKPKWamNVAILLSHANSVVNPIVYAYRNRDFRYTF 294
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
71-347 2.82e-14

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 72.71  E-value: 2.82e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  71 IMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALA-------TSTLPFQSVNYLMGTWPFgtILCKIV 143
Cdd:cd14972   1 VLVVAIVLGVFIVVENSLVLAAIIKNRRLHKPMYILIANLAAADLLAgiafvftFLSVLLVSLTPSPATWLL--RKGSLV 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 144 ISidyynMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIG-LPVMFMATTKYRQGSidCTLTFS 222
Cdd:cd14972  79 LS-----LLASAYSLLAIAVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVLLAlLPVLGWNCVLCDQES--CSPLGP 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 223 HptwYWENLLkICVFIFaFIMPVLIITVCYGLMILRLKS--VRMLSGSKEKDRNLRRITRMVLVVVAVFIV----CWTPI 296
Cdd:cd14972 152 G---LPKSYL-VLILVF-FFIALVIIVFLYVRIFWCLWRhaNAIAARQEAAVPAQPSTSRKLAKTVVIVLGvflvCWLPL 226
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 84370244 297 HIYVIIkaLITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd14972 227 LILLVL--DVLCPSVCDIQAVFYYFLVLALLNSAINPIIYAFRLKEMRRAV 275
7tmA_FFAR cd14983
free fatty acid receptors, member of the class A family of seven-transmembrane G ...
71-347 7.79e-14

free fatty acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the free fatty acid receptors (FFARs) which bind free fatty acids (FFAs). They belong to the class A G-protein coupled receptors and are composed of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR1 is a receptor for medium- and long-chain FFAs, whereas FFAR2 and FFAR3 are receptors for short chain FFAs (SCFAs), which have different ligand affinities. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and also indirectly increases insulin secretion by enhancing the release of incretin. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to the inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320114 [Multi-domain]  Cd Length: 278  Bit Score: 71.70  E-value: 7.79e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  71 IMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATN-IYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYY 149
Cdd:cd14983   3 SLMVYVLTILLGLPSNLLALYAFVNRARLRLTPNvIYMINLCLSDLVFILSLPIKIVEALSSAWTLPAVLCPLYNLAHFS 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 150 NMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSsaiGLPVMFMATTKYRQGSIDCTLTFSHPTWYWE 229
Cdd:cd14983  83 TLYASTCFLTAISAGRYLGVAFPIKYQLYKKPLYSCLVCVAIWALV---IFHVTLVFILETSGGTLDINTPVGNSSTCYE 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 230 NL------------LKICVFIFaFImPVLIITVCYglmilrLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIH 297
Cdd:cd14983 160 NFtpeqlallapvrLELSLVLF-FL-PLAITAFCY------VRCIRILVRSRLHERRKRRAVRVAVSTLLTFVVCFGPYN 231
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 84370244 298 IYVIIKALITipettfQTVSWHfCIAL--GYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd14983 232 ISHVVGFVRH------ESVWWR-KLALltSTCNAFLDPLIFYFLSSSMERGF 276
7tmA_NPY5R cd15398
neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G ...
71-344 1.02e-13

neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320520 [Multi-domain]  Cd Length: 273  Bit Score: 70.95  E-value: 1.02e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  71 IMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISIDYY 149
Cdd:cd15398   3 LIGLYTFISLLGFLGNLLILTALTKKWKQKTIINFLIGNLAFSDILvVLFCSPFTLTCVLLDQWIFGEVMCHIVPFLQCV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 150 NMFTSIFTLCTMSVDRYIAVCHPVKalDFRTPRNAKIVNVCNWILSSAIGLPV-MFMATTKYRQGSIDCTLTF------S 222
Cdd:cd15398  83 SVMVSTLMLMSIAIVRYHMIKHPLS--NHLTANHGYFLLGTVWTLGFTICSPLpVFHKIVDLSETFNLESLKNkylcieS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 223 HPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRmlsgskekdRNLRRITRMVLVVVAVfivcWTPIHIYVII 302
Cdd:cd15398 161 WPSDSYRIAFTISLLFVQYILPLVCLTVSHTSVCRSVKRSR---------SVFYRLTIVILAFAVS----WMPLHLFHLV 227
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 84370244 303 KALIT--IPETTFQTVsWHFCIALGYTNSCLNPVLYAFLDENFK 344
Cdd:cd15398 228 TDFNAnlISNRHFKLV-YCICHLLGMLSCCLNPILYGFLNNGIK 270
7tmA_SWS1_opsin cd15076
short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G ...
73-346 1.16e-13

short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 1 (SWS1), which mediates visual transduction in response to light at short wavelengths (ultraviolet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320204 [Multi-domain]  Cd Length: 280  Bit Score: 71.00  E-value: 1.16e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  73 ALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQS-VNYLMGTWPFGTILCKIVISIDYYNM 151
Cdd:cd15076   5 AFMGFVFIVGTPLNAIVLFVTIKYKKLRQPLNYILVNISLAGFIFCIFSVFPVfVASAQGYFFFGRTVCALEAFVGSLAG 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 152 FTSIFTLCTMSVDRYIAVCHPVKALDFRTpRNAKIVNVCNWILSSAIGLPVmFMATTKYRQGSIDCTLTfshPTWYW--- 228
Cdd:cd15076  85 LVTGWSLAFLAFERYIVICKPFGNFRFGS-KHALGAVVATWIIGIGVSLPP-FFGWSRYIPEGLQCSCG---PDWYTvgt 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 229 ---ENLLKICVFIFAFIMPVLIITVCYGLMILRLKSV---RMLSGSKEKDRnlRRITRMVLVVVAVFIVCWTPIHIYVII 302
Cdd:cd15076 160 kyrSEYYTWFLFIFCFIVPLSIIIFSYSQLLGALRAVaaqQQESASTQKAE--REVSRMVVVMVGSFCLCYVPYAALAMY 237
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 84370244 303 KA----------LITIPettfqtvswhfciALGYTNSCL-NPVLYAFLDENFKRC 346
Cdd:cd15076 238 MVnnrdhgldlrLVTIP-------------AFFSKSSCVyNPIIYCFMNKQFRAC 279
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
77-345 1.20e-13

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 71.09  E-value: 1.20e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  77 IVCVVGLFGNFLVMYVI-VRYTKMkTATNIYIFNLALAD--------ALATSTLPFQSV--NYLMGtWPFGTiLCKIVIS 145
Cdd:cd15136   9 FVFLLALVGNIIVLLVLlTSRTKL-TVPRFLMCNLAFADfcmgiylgLLAIVDAKTLGEyyNYAID-WQTGA-GCKTAGF 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 146 IDYYNMFTSIFTLCTMSVDRYIAVCHPVKaLDFR-TPRNAKIVNVCNWILSSAIG-LPVMFMATtkYRQGSIdCtLTFSH 223
Cdd:cd15136  86 LAVFSSELSVFTLTVITLERWYAITHAMH-LNKRlSLRQAAIIMLGGWIFALIMAlLPLVGVSS--YSKTSI-C-LPFET 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 224 PTwyweNLLKICV-FIFAF-IMPVLIITVCYGLMILRLKSVRMLSGSKEkdrnlRRITRMVLVVVAVFIVCWTPIHIYVI 301
Cdd:cd15136 161 ET----PVSKAYViFLLLFnGLAFLIICGCYIKIYLSVRGSGRAANSND-----TRIAKRMALLVFTDFLCWAPIAFFGL 231
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 84370244 302 IKA----LITIPETTFQTVswhFCIALgytNSCLNPVLYAFLDENFKR 345
Cdd:cd15136 232 TAAfglpLISVSNAKILLV---FFYPL---NSCANPFLYAIFTKQFRR 273
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
77-345 1.51e-13

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 70.69  E-value: 1.51e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  77 IVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL--------ATSTLPFQSV-NYLMGTWpFGTILCKIVISID 147
Cdd:cd15137   9 VVGIIALLGNLFVLIWRLKYKEENKVHSFLIKNLAIADFLmgvylliiASVDLYYRGVyIKHDEEW-RSSWLCTFAGFLA 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 148 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFrTPRNAKIVNVCNWILSSAI-GLPVMFMATTKYRQG-SIDC-TLTFSHP 224
Cdd:cd15137  88 TLSSEVSVLILTLITLDRFICIVFPFSGRRL-GLRRAIIVLACIWLIGLLLaVLPLLPWDYFGNFYGrSGVClPLHITDE 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 225 T---WYWENLLKICVFIFAFimpvLIITVCYGLMILRLKSVRmLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIhiyVI 301
Cdd:cd15137 167 RpagWEYSVFVFLGLNFLAF----VFILLSYIAMFISIRRTR-KAAASRKSKRDMAVAKRFFLIVLTDFLCWIPI---IV 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 84370244 302 IKAL----ITIPETTFqtvSWHFCIALGyTNSCLNPVLYAFLDENFKR 345
Cdd:cd15137 239 IGILalsgVPIPGEVY---AWVAVFVLP-INSALNPILYTLSTPKFRK 282
7tmA_5-HT5 cd15328
serotonin receptor subtype 5, member of the class A family of seven-transmembrane G ...
69-347 2.00e-12

serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; 5-HT5 receptor, one of 14 mammalian 5-HT receptors, is activated by the neurotransmitter and peripheral signal mediator serotonin (also known as 5-hydroxytryptamine or 5-HT). The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/0) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320451 [Multi-domain]  Cd Length: 259  Bit Score: 66.90  E-value: 2.00e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGT-WPFGTILCKIVISI 146
Cdd:cd15328   1 VLVLTLLAMLVVATFLWNLLVLVTILRVRTFHRVPHNLVASMAVSDVLvAALVMPLSLVHELSGRrWQLGRSLCQVWISF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 147 DYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGL-PVMFMATTKYRQGSIDCTLTfSHPT 225
Cdd:cd15328  81 DVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRRRISNVMIALTWALSAVISLaPLLFGWGETYSEDSEECQVS-QEPS 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 226 WywenllKICVFIFAFIMPVLIITVCYGLMilrlksvrMLSGSKEKdrnlrRITRMVLVVVAVFIVCWTPIHIYVIIKAL 305
Cdd:cd15328 160 Y------TVFSTFGAFYLPLCVVLFVYWKI--------YKAAQKEK-----RAALMVGILIGVFVLCWIPFFLTELISPL 220
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 84370244 306 IT--IPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15328 221 CScdIPPIWKSIFLW-----LGYSNSFFNPLIYTAFNKNYNNAF 259
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
72-347 2.09e-12

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 67.65  E-value: 2.09e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  72 MALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQ---SVNYLMGTWPFGTILCKIVISID 147
Cdd:cd15068   4 ITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADiAVGVLAIPFAitiSTGFCAACHGCLFIACFVLVLTQ 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 148 yynmfTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAK-IVNVCnWILSSAIGLPVMF------------MATTKYRQGS 214
Cdd:cd15068  84 -----SSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKgIIAIC-WVLSFAIGLTPMLgwnncgqpkegkNHSQGCGEGQ 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 215 IDCTLTFSHPTWYwenlLKICVFIFAFIMPVLIITVCYGLMIL----RLKSVRMLSGSKEKDRN-LRR---ITRMVLVVV 286
Cdd:cd15068 158 VACLFEDVVPMNY----MVYFNFFACVLVPLLLMLGVYLRIFLaarrQLKQMESQPLPGERARStLQKevhAAKSLAIIV 233
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 84370244 287 AVFIVCWTPIHiyvIIKALITIPETTFQTVSW--HFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15068 234 GLFALCWLPLH---IINCFTFFCPDCSHAPLWlmYLAIVLSHTNSVVNPFIYAYRIREFRQTF 293
7tmA_Retinal_GPR cd15072
retinal G protein coupled receptor, member of the class A family of seven-transmembrane G ...
72-344 2.16e-12

retinal G protein coupled receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the retinal G-protein coupled receptor (RGR) found exclusively in retinal pigment epithelium (RPE) and Muller cells. RGR is a member of the class A rhodopsin-like receptor family. As with other opsins, RGR binds all-trans retinal and contains a conserved lysine reside on the seventh helix. RGR functions as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. Two mutations in RGR gene are found in patients with retinitis pigmentosa, indicating that RGR is essential to the visual process.


Pssm-ID: 320200 [Multi-domain]  Cd Length: 260  Bit Score: 67.00  E-value: 2.16e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  72 MALYSIVCV---VGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDY 148
Cdd:cd15072   1 FAVGSILLVealVGFSLNGLTILSFCKTRELRTPSNLLVLSLAVADMGISLNALVAASSSLLRRWPYGSEGCQAHGFQGF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 149 YNMFTSIFTLCTMSVDRYIAVCHPvkalDFRTPRNAKIVNVCNWILSSA-IGLPVMFMATTKYRQGSIDCTLTFSHPTWY 227
Cdd:cd15072  81 FTALASICSSAAIAWDRYHHYCTR----SKLQWSTAISLVLFVWLFSAFwAAMPLLGWGEYDYEPLGTCCTLDYSKGDRN 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 228 WENLLkICVFIFAFIMPVLIITVCYGLMILRLKsvrmlsgsKEKdrnlrRITRMVLVVVAVFIVCWTPihiYVIIKALIT 307
Cdd:cd15072 157 YVSYL-FTMAFFNFILPLFILLTSYSSIEQKLK--------KEG-----HLRFNTGLPLLTLLICWGP---YAILALYAA 219
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 84370244 308 IPETTFqtVS---WHFCIALGYTNSCLNPVLYAFLDENFK 344
Cdd:cd15072 220 ITDVTS--ISpklRMVPALLAKTSPTINAILYALGNENYR 257
7tmA_5-HT1A_invertebrates cd15331
serotonin receptor subtype 1A from invertebrates, member of the class A family of ...
69-347 4.46e-12

serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320454 [Multi-domain]  Cd Length: 261  Bit Score: 66.22  E-value: 4.46e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISID 147
Cdd:cd15331   1 VLTSIILGLLILATIIGNVFVIAAILLERSLQGVSNYLILSLAVADLMvAVLVMPLSAVYEVSQHWFLGPEVCDMWISMD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 148 YYNMFTSIFTLCTMSVDRYIAVCHpVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFmattkyrqgsidctlTFSHPT-W 226
Cdd:cd15331  81 VLCCTASILHLVAIALDRYWAVTN-IDYIRRRTAKRILIMIAVVWFVSLIISIAPLF---------------GWKDEDdL 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 227 YWENLLKICVF-------IF----AFIMPVLIITVCYglmilrlksVRMLSGSKEKdrnlRRITRMVLVVVAVFIVCWTP 295
Cdd:cd15331 145 DRVLKTGVCLIsqdygytIFstvgAFYVPLLLMIIIY---------WKIYQAAKRE----RKAARTLAIITGAFVVCWLP 211
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 84370244 296 IHIYVIIKAL---ITIPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15331 212 FFLVALVMPFcgaWQISRFLESFFLW-----LGYFNSLLNPIIYTIFSPDFRGAF 261
7tmA_P2Y13 cd15151
P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled ...
74-345 4.61e-12

P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y13 receptor (P2Y13R) is activated by adenosine diphosphate (ADP) and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341327  Cd Length: 284  Bit Score: 66.34  E-value: 4.61e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  74 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATnIYIFNLALADALATSTLPFQSV-NYLMGTWPFGTILCKIVISIDYYNMF 152
Cdd:cd15151   6 LYTVLFLVGLILNSVAAWIFFHIPSTSTFI-VYLKNTLVADLIMTLMLPFKILsDSGLGPWQLRAFVCRFSAVVFYITMY 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 153 TSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSI-DCTLTFSHPTWYW-EN 230
Cdd:cd15151  85 ISIILLGLISFDRYLKIVRPFGKSWVQRVRFAKILSGAVWLVMFLLSVPNMILSNKPATPISVkKCASLKSPLGLKWhEV 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 231 LLKICVFIFAFIMPVLIitVCYglMILRLKSVRMLSGSKEKDRNLRRITRMVL-VVVAVFIVCWTPIHiyviikaLITIP 309
Cdd:cd15151 165 VNYICQFIFWGVFALMV--LFY--TIISKKVYESYKKSRSKDNKASKKTKAKVfIIVAVFFVCFAPFH-------FVRVP 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 84370244 310 ETTFQTVSWHFCIA-------------LGYTNSCLNPVLYAFLDENFKR 345
Cdd:cd15151 234 YTLSQTGKITDCQLqnllyiakeitlwLAATNVCLDPLIYIFLCKSFRQ 282
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
69-347 1.36e-11

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 64.83  E-value: 1.36e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISID 147
Cdd:cd15054   1 GWVAAFLCLIILLTVAGNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMvGLVVMPPAMLNALYGRWVLARDFCPIWYAFD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 148 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTwy 227
Cdd:cd15054  81 VMCCSASILNLCVISLDRYLLIISPLRYKLRMTPPRALALILAAWTLAALASFLPIELGWHELGHERTLPNLTSGTVE-- 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 228 wenllKICVF-----------IFAFIMPVLIITVCYGLMILRLKsvRMLSGSkekdRNLRRITRMVLVVvavfivcWTPI 296
Cdd:cd15054 159 -----GQCRLlvslpyalvasCLTFFLPSGAICFTYCRILLAAR--KALKAS----LTLGILLGMFFVT-------WLPF 220
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 84370244 297 HIYVIIKALI-TIPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15054 221 FVANVVQAVCdCVSPGLFDVLTW-----LGYCNSTMNPIIYPLFMRDFKRAL 267
7tmA_GPR39 cd15135
G protein-coupled receptor 39, member of the class A family of seven-transmembrane G ...
69-347 1.44e-11

G protein-coupled receptor 39, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR39 is an orphan G protein-coupled receptor that belongs to the growth hormone secretagogue and neurotensin receptor subfamily. GPR39 is expressed in peripheral tissues such as pancreas, gut, gastrointestinal tract, liver, kidney as well as certain regions of the brain. The divalent metal ion Zn(2+) has been shown to be a ligand capable of activating GPR39. Thus, it has been suggested that GPR39 function as a G(q)-coupled Zn(2+)-sensing receptor which involved in the regulation of endocrine pancreatic function, body weight, gastrointestinal mobility, and cell death.


Pssm-ID: 320263 [Multi-domain]  Cd Length: 320  Bit Score: 65.20  E-value: 1.44e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFL---VMYVIVRYTKMKTATNIYIFNLALADALATST-LP--FQSVNYLMGTWPFGTILCKI 142
Cdd:cd15135   1 ITLTLLYSLILVAGILGNSAtikVTQVLQKKGYLQKSVTDHMVSLACSDLLVLLLgMPveLYSAIWDPFATPSGNIACKI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 143 visidYYNMF-----TSIFTLCTMSVDRYIAVCHPVKALDFRtPRNAKIVNVCNWILSSAIGLPVMF-MATTKYRQGSID 216
Cdd:cd15135  81 -----YNFLFeacsyATILNVATLSFERYIAICHPFKYKALS-GSRVRLLICFVWLTSALVALPLLFaMGTEDPLEAFPS 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 217 CTLTFSHPTWYWENlLKIC--------VF---IFAFIMPVLIITVCYGLMILRLKSV--RMLSG---------------- 267
Cdd:cd15135 155 YRGTRHHCQDQKSN-LTICtslsskwtVFqasIFSAFVLYLLVLASVAFMCRRMMRAlmGSKKGavavkgpggsvqllrk 233
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 268 --SKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKA-----------------LITIPETTFqtvswhfcialgYTN 328
Cdd:cd15135 234 heSAEGKTARKQTILFLGLIVGTLAVCWMPNQIRRIMAAakpkddwtrsyfrayiiLLPIADTFF------------YLS 301
                       330
                ....*....|....*....
gi 84370244 329 SCLNPVLYAFLDENFKRCF 347
Cdd:cd15135 302 SVLNPLLYNLSSQQFRSVF 320
7tmA_Encephalopsin cd15078
encephalopsins (opsin-3), member of the class A family of seven-transmembrane G ...
78-346 1.79e-11

encephalopsins (opsin-3), member of the class A family of seven-transmembrane G protein-coupled receptors; Encephalopsin, also called Opsin-3 or Panopsin, is a mammalian extra-retinal opsin that is highly localized in the brain. It is thought to play a role in encephalic photoreception. Encephalopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320206 [Multi-domain]  Cd Length: 279  Bit Score: 64.46  E-value: 1.79e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  78 VCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST-LPFQSVNYLMGTWPFGTILCkiVISIDYYNMF--TS 154
Cdd:cd15078  10 IGFLGVCNNLLVLILYYKFKRLRTPTNLLLVNISLSDLLVSLLgVTFTFMSCVRGRWVFDVAGC--VWDGFSNSLFgiVS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 155 IFTLCTMSVDRYIAVCHpVKALDFRTPRNAkIVNVcnWILSSA-IGLPVMFMATTKYRQGSIDCTLTFShPTWYWENLLK 233
Cdd:cd15078  88 IMTLTVLAYERYIRVVH-AKVVNFSWSWRA-ITYI--WLYSLAwTGAPLLGWNRYTLEVHGLGCSFDWK-SKDPNDTSFV 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 234 ICVFIFAFIMPVLIITVCYGLM---ILRLKSVRMLSGSKEKD--RNLRRITRMVLVVVAVFIVCWTPihiYVIIKALITI 308
Cdd:cd15078 163 LLFFLGCLVVPLGIMAYCYGHIlyeIRMLRSVEDLQTFQVIKilKYEKKVAKMCLLMISTFLICWMP---YAVVSLLVTS 239
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 84370244 309 PETTFQTVSWHFCIAL-GYTNSCLNPVLYAFLDENFKRC 346
Cdd:cd15078 240 GYSKLVTPTIAIIPSLfAKSSTAYNPVIYIFMIRKFRQC 278
7tmA_GPR26_GPR78-like cd15219
G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...
77-345 4.11e-11

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320347 [Multi-domain]  Cd Length: 264  Bit Score: 63.25  E-value: 4.11e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  77 IVCVVGLFGNFLVMYVIVRYTKMKT-ATNIYIFNLALADALAT-STLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTS 154
Cdd:cd15219   8 VVLVVSLLSNLLVLLCFLYSAELRKqVPGIFLLNLSFCNLLLTvLNMPFTLLGVVRNRQPFGDGFCQAVGFLETFLTSNA 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 155 IFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPtwywENLLKI 234
Cdd:cd15219  88 MLSMAALSIDRWIAVVFPLSYTSKMRYRDAALMVGYSWLHSLTFSLVALFLSWLGYSSLYASCTLHLPRE----EERRRF 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 235 CVF-----IFAFIMPVLIITVCYgLMILRLksvrmlsgskekdRNLRRITRMVLVVVAVFIVCWTPihiYVIIKALITIP 309
Cdd:cd15219 164 AVFtaffhAFTFLLSLLVLCVTY-LKVLKV-------------RRRQRATKKISIFIGTFVLCFAP---YVITRLVELLP 226
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 84370244 310 ettFQTVSWHFCI---ALGYTNSCLNPVLYAFLDENFKR 345
Cdd:cd15219 227 ---FVTINRYWGIvskCLTYSKAASDPFVYSLLRQQYRK 262
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
68-342 5.88e-11

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 62.86  E-value: 5.88e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  68 AITIMALYSIVCVVGLfGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST-LPFQSVNYLMG-TWPFGTILCKIVIS 145
Cdd:cd15212   1 AAQALVLLAIFLLSSL-GNCAVIGVIVKHRQLRTVTNAFILSLSLSDLLTALLcLPFAFLTLFSRpGWLFGDRLCLANGF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 146 IDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRtpRNAKIVNVCNWILSSAIGLPVMFMAT---TKYRQGSIDCTLTFS 222
Cdd:cd15212  80 FNACFGIVSTLTMTLISFDRYYAIVRQPQGKIGR--RRALQLLAAAWLTALGFSLPWYLLASapeYYEKLGFYHCLYVLH 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 223 HPTWYWENLLKICVFIFAFIMPVLIITVC-YGL-MILRLKSVRMLSGSKEKdRNLR-----RITRMVLVVVAVFIVCWTP 295
Cdd:cd15212 158 SGPSRLGAAYSSVLIVLCYLLPFALMCFChYNIcKTVRLSESRVRPVTTYA-HLLRfysemRTATTVLIMIVFIICCWGP 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 84370244 296 IHIYVIIKALI--TIPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDEN 342
Cdd:cd15212 237 YCLLGLVAAAGgyQFPPLMDTVAIW-----MAWANGAINPLIYAIRNPN 280
7tmA_GPR45 cd15403
G protein-coupled receptor 45, member of the class A family of seven-transmembrane G ...
69-201 6.58e-11

G protein-coupled receptor 45, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR45 and closely related proteins found in vertebrates. GPR45 is also called PSP24 in Xenopus and PSP24-alpha (or PSP24-1) in mammals. GPR45 shows the highest sequence homology with GPR63 (PSP24-beta, or PSP24-2). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320525 [Multi-domain]  Cd Length: 301  Bit Score: 62.94  E-value: 6.58e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCKIVISID 147
Cdd:cd15403   1 ILLAIVMILMIAIGFLGNAIVCLIVYQKPAMRSAINLLLATLAFSDiMLSLLCMPFTAVTIITVDWHFGAHFCRISAMLY 80
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 84370244 148 YYNMFTSIFTLCTMSVDRYIAVchpVKALDFRTPRNAKIVNVCNWILSSAIGLP 201
Cdd:cd15403  81 WFFVLEGVAILLIISVDRFLII---VQRQDKLNPHRAKVMIAISWVLSFCISFP 131
7tmA_GPR63 cd15404
G protein-coupled receptor 63, member of the class A family of seven-transmembrane G ...
69-344 1.94e-10

G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR63, which is also called PSP24-beta or PSP24-2, and its closely related proteins found in vertebrates. GPR63 shares the highest sequence homology with GPR45 (Xenopus PSP24, mammalian PSP24-alpha or PSP24-1). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320526 [Multi-domain]  Cd Length: 265  Bit Score: 61.39  E-value: 1.94e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADA-LATSTLPFQSVNYLMGTWPFGTILCKIVISID 147
Cdd:cd15404   1 VILSAVMIFILLVSFLGNFVVCLMVYQKAAMRSAINILLASLAFADMmLAVLNMPFALVTIITTRWIFGDAFCRVSAMFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 148 YYNMFTSIFTLCTMSVDRYIAVchpVKALDFRTPRNAKIVNVCNWILSSAIGLPVMF-MATTKYRQGSIDCTLTFSHPTW 226
Cdd:cd15404  81 WLFVMEGVAILLIISIDRFLII---VQKQDKLNPYRAKVLIAVSWAVSFCVAFPLAVgSPDLQIPSRAPQCVFGYTTNPG 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 227 YweNLLKICVFIFAFIMPVLIITvcYGLMILrLKSVRMLsgskeKDRNLRRITRMVLVvvavFIVCWTPIHIYVIIKAL- 305
Cdd:cd15404 158 Y--QAYVILIMLIFFFIPFMVML--YSFMGI-LNTVRSF-----KTRAFTTILILFIV----FTVCWAPFTTYSLVATFn 223
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 84370244 306 --ITIPETTFQTVSWhfCIALGYTNSCLNPVLYAFLDENFK 344
Cdd:cd15404 224 shFYHKHNFFEISTW--LLWLCYLKSALNPLIYYWRIKKFR 262
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
68-204 4.39e-10

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 60.93  E-value: 4.39e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  68 AITIMALYSIVCVvGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPF--QSVNYLMGtWPFGTILCKIVI 144
Cdd:cd15005   1 ALKLTTLGLILCV-SLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLrSLACFPFvmASVRHGSG-WIYGALSCKVIA 78
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 84370244 145 SIDYYNMFTSIFTLCTMSVDRYIAVCHP---VKALDFRTprnAKIVNVCNWILSSAIGLPVMF 204
Cdd:cd15005  79 FLAVLFCFHSAFTLFCIAVTRYMAIAHHrfyAKRMTFWT---CLAVICMAWTLSVAMAFPPVF 138
7tmA_Adenosine_R_A1 cd15071
adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...
72-347 8.62e-10

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.


Pssm-ID: 341323 [Multi-domain]  Cd Length: 290  Bit Score: 59.48  E-value: 8.62e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  72 MALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTilCKIVISIDYYN 150
Cdd:cd15071   4 IGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADvAVGALVIPLAIIINIGPQTEFYS--CLMVACPVLIL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 151 MFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYR-QGSIDCTLTFSHP--TWY 227
Cdd:cd15071  82 TQSSILALLAIAVDRYLRVKIPTRYKSVVTPRRAAVAIAGCWILSFLVGLTPMFGWNNLNAvERAWAANSSMGELviKCQ 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 228 WENLLKICVFI----FAFIMPVLIITVCYGLMILRL--KSVRMLSGSKEKDRNLR-----RITRMVLVVVAVFIVCWTPI 296
Cdd:cd15071 162 FETVISMEYMVyfnfFVWVLPPLLLMLLIYLEVFYLirKQLNKKVSSSSSDPQKYygkelKIAKSLALILFLFALSWLPL 241
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 84370244 297 HIYVIIKalITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15071 242 HILNCIT--LFCPSCKKPMILTYIAIFLTHGNSAMNPIVYAFRIKKFRTTF 290
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
76-344 1.61e-09

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 58.64  E-value: 1.61e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  76 SIVCVVGL---FGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTIL---CKIVisidy 148
Cdd:cd15070   5 SIEILIGLcavVGNVLVIWVVKLNPSLRTTTFYFIVSLALADiAVGVLVIPLAIVVSLGVTIHFYSCLfmsCLLV----- 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 149 ynMFT--SIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMF---MATTKYRQGS--IDCTLT- 220
Cdd:cd15070  80 --VFThaSIMSLLAIAVDRYLRVKLTVRYRIVTTQRRIWLALGLCWLVSFLVGLTPMFgwnRKPSLESVNTtpLQCQFTs 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 221 ---------FSHPTWywenllkicVFIFAFIMPVLIITVCYglmILRLKSVRMLSGSKEKDRNLRR---ITRMVLVVVAV 288
Cdd:cd15070 158 vmrmdymvyFSFFTW---------ILIPLVIMCALYVDIFY---IIRNKLSQNATGFRETGAFYGRefkTAKSLALVLFL 225
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 84370244 289 FIVCWTPIHIY-VIIKALITIPETTFqtvswHFCIALGYTNSCLNPVLYAFLDENFK 344
Cdd:cd15070 226 FAVCWLPLSIInCVVYFNPKVPKIAL-----YLGILLSHANSMMNPIVYACKIKKFK 277
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
72-302 1.78e-09

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 58.41  E-value: 1.78e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  72 MALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIF--NLALADALAT-STLPFQSVNYLMG-TWPFGTILCKivisid 147
Cdd:cd14981   4 PAPPALMFVFGVLGNLLALIVLARSSKSHKWSVFYRLvaGLAITDLLGIlLTSPVVLAVYASNfEWDGGQPLCD------ 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 148 yYNMFTSIFT-------LCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIG-LPVM-FMATTKYRQGSIdCT 218
Cdd:cd14981  78 -YFGFMMSFFglsslliVCAMAVERFLAITHPFFYNSHVKKRRARLMLGAVWAFALLIAsLPLLgLGSYVLQYPGTW-CF 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 219 LTFSHPTWywenLLKICVFIFAFIMPVLI-------ITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMV---LVVVAV 288
Cdd:cd14981 156 LDFYSKNT----GDAAYAYLYSILGLLILlvtllcnLLVIITLLRMRRRKKRHRRSRRSARRQKRNEIQMVvllLAITVV 231
                       250
                ....*....|....
gi 84370244 289 FIVCWTPIHIYVII 302
Cdd:cd14981 232 FSVCWLPLMIRVLI 245
7tmA_LWS_opsin cd15081
long wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
77-346 1.89e-09

long wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Long Wave-Sensitive opsin is also called red-sensitive opsin or red cone photoreceptor pigment, which mediates visual transduction in response to light at long wavelengths. Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320209 [Multi-domain]  Cd Length: 292  Bit Score: 58.38  E-value: 1.89e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  77 IVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD---ALATSTLPFqsVNYLMGTWPFGTILCKIVISIDYYNMFT 153
Cdd:cd15081  21 FVVFASVFTNGLVLVATLKFKKLRHPLNWILVNLAIADlgeTVIASTISV--VNQIFGYFILGHPMCVLEGFTVSVCGIT 98
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 154 SIFTLCTMSVDRYIAVCHPVKALDFRTpRNAKIVNVCNWILSSAIGLPVMFMATTKYRQG-SIDCTL-TFSHPTWYWENL 231
Cdd:cd15081  99 GLWSLTIISWERWVVVCKPFGNIKFDG-KLAIVGIIFSWVWSAVWCAPPIFGWSRYWPHGlKTSCGPdVFSGSSDPGVQS 177
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 232 LKICVFIFAFIMPVLIITVCYGLMILRLKSV-RMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKAliTIPE 310
Cdd:cd15081 178 YMIVLMITCCIIPLAIIILCYLQVWLAIRAVaQQQKESESTQKAEKEVSRMVVVMIFAYCFCWGPYTFFACFAA--ANPG 255
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 84370244 311 TTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRC 346
Cdd:cd15081 256 YAFHPLAAALPAYFAKSATIYNPIIYVFMNRQFRNC 291
7TM_GPCR_Srx pfam10328
Serpentine type 7TM GPCR chemoreceptor Srx; Chemoreception is mediated in Caenorhabditis ...
77-281 5.99e-09

Serpentine type 7TM GPCR chemoreceptor Srx; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srx is part of the Srg superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 431215  Cd Length: 262  Bit Score: 56.84  E-value: 5.99e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244    77 IVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST-----LPFQSVNYLMGTWPFGTILCKIVISIDYYNm 151
Cdd:pfam10328   2 LISLIGLVANLLVFIAFLKLPSLKNSFGILCLSQAIGNAIICLIflfyvVPMTLFQNSFLPEWLNSHIIGLIAMGLYEI- 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244   152 ftSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFmattkyrqgSIDCTLTFSHPTWYWENL 231
Cdd:pfam10328  81 --SPLSHLLIALNRFCAVFFPLKYEKIFSIKNTKIIIIFIWIVSIIFCTVFYE---------PEGCHFYYNPETLTWSFE 149
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 84370244   232 L-KICVFI-----FAFIMPVLIITVCYGLMI---LRLKSVRMLSGSKEKDRNLRRITRM 281
Cdd:pfam10328 150 DtPCCDFItwyldFYKNLSLVIITLFLNLLTaikLRVSKKKSNTSSSESKRRRKREINF 208
7tmA_GPR61_GPR62-like cd15220
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...
80-340 7.84e-09

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.


Pssm-ID: 410633 [Multi-domain]  Cd Length: 264  Bit Score: 56.30  E-value: 7.84e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  80 VVGLFGNFLVMYVIVRYTKMKTAtnIYIFNLALADALATSTL-PFQ--SVNYLMGTWPFGTILCKIVISIDYYNMFTSIF 156
Cdd:cd15220  11 LTALVGNTAVMVVIAKTPHLRKF--AFVCHLCVVDLLAALLLmPLGilSSSPFFLGVVFGEAECRVYIFLSVCLVSASIL 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 157 TLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSI---DCTLTFSHptwywENLLK 233
Cdd:cd15220  89 TISAISVERYYYIVHPMRYEVKMTIGLVAAVLVGVWVKALLLGLLPVLGWPSYGGPAPIaarHCSLHWSH-----SGHRG 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 234 ICVFIFA---FIMPVLIITVCYGLMIlrlksvRMLSGSKEkdrnlrriTRMVLVVVAVFIVCWTP---IHIYVIIKALIT 307
Cdd:cd15220 164 VFVVLFAlvcFLLPLLLILVVYCGVF------KVFGGGKA--------ALTLAAIVGQFLCCWLPyfaFHLYSALAASPV 229
                       250       260       270
                ....*....|....*....|....*....|...
gi 84370244 308 IPETTFQTVSWhfciaLGYTNSCLNPVLYAFLD 340
Cdd:cd15220 230 SGGEAEEVVTW-----LAYSCFAVNPFFYGLLN 257
7tmA_SREB3_GPR173 cd15217
super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...
72-347 2.08e-08

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320345 [Multi-domain]  Cd Length: 329  Bit Score: 55.73  E-value: 2.08e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  72 MALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST-LPFQSVNYLMGT-WPFGTILCKIVISIDYY 149
Cdd:cd15217   4 LVLLGLIICVSLAGNLIVSLLVLKDRALHKAPYYFLLDLCLADTIRSAVcFPFVLVSIRNGSaWTYSVLSCKIVAFMAVL 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 150 NMFTSIFTLCTMSVDRYIAVCHP---VKALDFRTPrnakIVNVCN-WILSSAIGLPVMF-MATTKYRQGSIDCtlTFSHP 224
Cdd:cd15217  84 FCFHAAFMLFCISVTRYMAIAHHrfySKRMTFWTC----IAVICMvWTLSVAMAFPPVFdVGTYKFIREEDQC--IFEHR 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 225 TWYWENLLKicvfiFAFIMPVLIIT--VCYGLMIL------RLKSVRMLSGSKE-------------------------- 270
Cdd:cd15217 158 YFKANDTLG-----FMLMLAVLIVAthIVYGKLLLfeyrhrKMKPVQMVPAISQnwtfhgpgatgqaaanwiagfgrgpm 232
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 271 -------------KDRNL---------RRITRMVLVVVAVFIVCWTP--IHIY--VIIKAlITIPETTFQTVSWhfciaL 324
Cdd:cd15217 233 pptllgirqnahtANRRLlgmeefkaeKRLGRMFYVITLSFLVLWSPyiVACYwrVFVKA-CSIPHRYLSTAVW-----M 306
                       330       340
                ....*....|....*....|...
gi 84370244 325 GYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15217 307 SFAQAGVNPIVCFLLNKDLKKCL 329
7tmA_GPR161 cd15214
orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...
68-255 6.93e-08

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320342 [Multi-domain]  Cd Length: 261  Bit Score: 53.40  E-value: 6.93e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  68 AITIMALYSIVCVvglfGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCKIVISI 146
Cdd:cd15214   3 SIAIIIIAILICL----GNLVIVVTLYKKSYLLTLSNKFVFSLTLSNlLLSVLVLPFVVTSSIRREWIFGVVWCNFSALL 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 147 DYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWiLSSAIG-LPVMF-MATTKYRQGSIDCTLTFSHP 224
Cdd:cd15214  79 YLLISSASMLTLGAIAIDRYYAVLYPMVYPMKITGNRAVLALVYIW-LHSLIGcLPPLFgWSSLEFDRFKWMCVAAWHKE 157
                       170       180       190
                ....*....|....*....|....*....|....
gi 84370244 225 ---TWYWEnllkicvfIFAFIMPVLIITVCYGLM 255
Cdd:cd15214 158 agyTAFWQ--------VWCALLPFVVMLVCYGFI 183
7tmA_PGE2_EP4 cd15142
prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G ...
70-172 1.71e-07

prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin E2 receptor EP4, also called prostanoid EP4 receptor, is one of four receptor subtypes whose endogenous physiological ligand is prostaglandin E2 (PGE2). Each of these subtypes (EP1-EP4) have unique but overlapping tissue distributions that activate different intracellular signaling pathways. Like the EP2 receptor, stimulation of the EP4 receptor by PGE2 causes cAMP accumulation through G(s) protein activation. Knockout studies in mice suggest that EP4 receptor may be involved in the maintenance of bone mass and fracture healing. Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320270 [Multi-domain]  Cd Length: 302  Bit Score: 52.50  E-value: 1.71e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  70 TIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIY--IFNLALADALATS-TLPFQSVNYLMGTWPFGTILCKIVISI 146
Cdd:cd15142   2 TPPTIPAVMFIFGVVGNLIAIVVLCKSRKEQKETTFYtlVCGLAVTDLLGTClASPVTIATYLKGRWPGGQPLCEYFSFI 81
                        90       100
                ....*....|....*....|....*.
gi 84370244 147 DYYNMFTSIFTLCTMSVDRYIAVCHP 172
Cdd:cd15142  82 LLFFSLSGLSIICAMSIERYLAINHA 107
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
68-347 4.32e-07

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 51.22  E-value: 4.32e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  68 AITIMALYSIVCVVGlfgNFLVMYVIVRYTKMK-TATNIYIFNLALADALATSTLPFQSVNYLMG-TWPFGTILCKIVIS 145
Cdd:cd15104   2 AGVILAVLSPLIITG---NLLVIVALLKLIRKKdTKSNCFLLNLAIADFLVGLAIPGLATDELLSdGENTQKVLCLLRMC 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 146 IDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIG-LPVMFMATTKYRQGSIDCTLTFSHP 224
Cdd:cd15104  79 FVITSCAASVLSLAAIAFDRYLALKQPLRYKQIMTGKSAGALIAGLWLYSGLIGfLPLISPQFQQTSYKGKCSFFAAFHP 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 225 twywENLLKICVFIFAFIMPVLIITVCYGLMILRLKS--VRMLSGSKEKDRNLRRIT------RMVLVVVAVFIVCWTPI 296
Cdd:cd15104 159 ----RVLLVLSCMVFFPALLLFVFCYCDILKIARVHSraIYKVEHALARQIHPRRTLsdfkaaRTVAVLIGCFLLSWLPF 234
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 84370244 297 HIYVIIKALITIPETTFQTVSWHFciALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15104 235 QITGLVQALCDECKLYDVLEDYLW--LLGLCNSLLNPWIYAFWQKEVRRAL 283
7tmA_GPR141 cd14994
orphan G protein-coupled receptor 141, member of the class A family of seven-transmembrane G ...
74-268 7.64e-07

orphan G protein-coupled receptor 141, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 141 of unknown function. Several ESTs for GPR141 were found in marrow and cancer cells. GPR141 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320125  Cd Length: 275  Bit Score: 50.56  E-value: 7.64e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  74 LYSIVCVVGLFGNFLVMYVIVRYTKmKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFT 153
Cdd:cd14994   7 LYSVVLIGGVIGVILMSFLLVKMNT-RSVTTTAVINLIVVHSLFLLTVPFRIYYYASKTWKFGMPLCKMVSAMIHIHMHL 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 154 SIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFsHPTWYWENLLK 233
Cdd:cd14994  86 TFLFYVIILVIRYLIFFQRKDKMEFYRKLHAVAASAVVWVLVLLIVVPVFVKEYGSSSSYNSDQCFKF-HKELEVHYVKV 164
                       170       180       190
                ....*....|....*....|....*....|....*
gi 84370244 234 ICVFIFAFIMPVLIITVCYGLMILrLKSVRMLSGS 268
Cdd:cd14994 165 LNYIIICIVLIVTLALLGFQVFIL-GHVYRKLRAS 198
7tmA_GPR37 cd15127
G protein-coupled receptor 37, member of the class A family of seven-transmembrane G ...
71-168 7.78e-07

G protein-coupled receptor 37, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR37, also called parkin-associated endothelin-like receptor (Pael-R), was isolated from a set of human brain frontal lobe expressed sequence tags. It is highly expressed in the mammalian CNS. It is a substrate of parkin and is involved in the pathogenesis of Parkinson's disease. GPR37 has recently been shown to act as a receptor for the neuropeptide prosaptide, the active fragment of the secreted neuroprotective and glioprotective factor prosaposin (also called sulfated glycoprotein-1). Both prosaptide and prosaposin protect primary astrocytes against oxidative stress. GPR37 is part of the class A family of GPCRs that includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320255 [Multi-domain]  Cd Length: 298  Bit Score: 50.62  E-value: 7.78e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  71 IMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATS-TLPFQSVNYLMGTWPFGTILCKIVISIDYY 149
Cdd:cd15127   3 VMCLSVVIFGIGIMGNVAVMCIVCHNYYMRSISNSLLANLAFWDFLIIFfCLPLVIFHELTKKWLLGDFSCKIVPYIEVA 82
                        90
                ....*....|....*....
gi 84370244 150 NMFTSIFTLCTMSVDRYIA 168
Cdd:cd15127  83 SLGVTTFTLCALCIDRFRA 101
7tmA_Mrgpr cd14973
mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G ...
69-339 8.96e-07

mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined. Also included in this family is Mas-related G-protein coupled receptor 1-like (MAS1L) which is only found in primates. The angiotensin-II metabolite angiotensin is an endogenous ligand for MAS1L.


Pssm-ID: 320104 [Multi-domain]  Cd Length: 272  Bit Score: 50.33  E-value: 8.96e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKmKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDY 148
Cdd:cd14973   1 LVIFSLTVLLSLCGLVGNGLVLWLLGFRIK-RNPFSVYILNLAAADFLFLSCQAIQSLEDLLGGSLPGFALCRLLATLMF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 149 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPvmfmattkyrqGSIDCTLTFSHPTWYW 228
Cdd:cd14973  80 FSYTVGLSLLAAISTERCLSVLFPIWYRCHRPKHLSAVVCALLWALSLLLSVL-----------ESYFCGFLFWKFNESA 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 229 -ENLLKICVFIFAFIMPVLIITvcyGLMILrlksVRMLSGSKEkdRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALIT 307
Cdd:cd14973 149 cRTFNFLSALLFLLLFLVMCVS---SLTLL----IRVQCSSQR--RPPTRLYVVILLTVLVFLLCGLPLGIYWFLLLWFS 219
                       250       260       270
                ....*....|....*....|....*....|..
gi 84370244 308 IPETTFQTVSWHFCIALgytNSCLNPVLYAFL 339
Cdd:cd14973 220 NYLFHTFHPISDLLSCV---NSSANPIIYFFV 248
7tmA_GPR139 cd15919
G-protein-coupled receptor GPR139, member of the class A family of seven-transmembrane G ...
75-193 9.63e-07

G-protein-coupled receptor GPR139, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR139, a vertebrate orphan receptor, is very closely related to GPR142, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and plays an important role in mediating insulin secretion and maintaining glucose homeostasis, whereas GPR139 is expressed almost exclusively in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139. These orphan receptors are phylogenetically clustered with invertebrate FMRFamide receptors such as Drosophila melanogaster DrmFMRFa-R.


Pssm-ID: 320585 [Multi-domain]  Cd Length: 270  Bit Score: 50.28  E-value: 9.63e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  75 YSIVCVVGLFGNFLVMYVIVRYT--KMKTATNiYIFNLALADALATSTLPFqsVNYLMGTW----PFGTILCKIVISIDY 148
Cdd:cd15919   7 YSLLLCLGLPANILTVIILSQLVarRQKSSYN-YLLALAAADILVLFFIVF--VDFLLEDFilnkQMPQVLDKIIEVLEF 83
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 84370244 149 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWI 193
Cdd:cd15919  84 SSIHTSIWITVPLTIDRYIAVCHPLKYHTVSYPARTRKVIVSVYI 128
7tmA_FFAR1 cd15169
free fatty acid receptor 1, member of the class A family of seven-transmembrane G ...
73-194 1.06e-06

free fatty acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the mammalian free fatty acid receptor 1 (FFAR1), also called GPR40. FFAR1 is a cell-surface receptor for medium- and long-chain free fatty acids (FFAs). The receptor is most potently activated by eicosatrienoic acid (C20:3), but can also be activated at micromolar concentrations of various fatty acids. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and indirectly increases insulin secretion by enhancing the release of incretin. Free fatty acid receptors (FFARs) belong to the class A G-protein coupled receptors and are comprised of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320297  Cd Length: 284  Bit Score: 50.01  E-value: 1.06e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  73 ALYSIVCVVGLFGNFLVMYVIVRYTKMK-TATNIYIFNLALADALATSTLPFQSVNYLM-GTWPFGTILCKIVISIDYYN 150
Cdd:cd15169   5 GLYVAAFALGFPLNVLAIRGATAHARLRlTPSLVYALNLGCSDLLLTVSLPLKAVEALAsGAWPLPASLCPVFAVAHFAP 84
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 84370244 151 MFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWIL 194
Cdd:cd15169  85 LYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWAL 128
PHA03235 PHA03235
DNA packaging protein UL33; Provisional
53-350 2.93e-06

DNA packaging protein UL33; Provisional


Pssm-ID: 223017 [Multi-domain]  Cd Length: 409  Bit Score: 49.43  E-value: 2.93e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244   53 NDSlCPQTGSPSMVTaITIMALYSIVCVVGLFGNFLVMYVIV---RYTKMKTATnIYIFNLALADALATSTLPF--QSVN 127
Cdd:PHA03235  19 NDT-CVPTEGLSAAR-TTETFINLLIISVGGPLNLIVLVTQLlanRVHGFSTPT-LYMTNLYLANLLTVFVLPFimLSNQ 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  128 YLMGTWPFGtilCKIViSIDYYNMFTSIF-TLCTMSVDRYiAVCHPVKALDFRTPRNAKIVNVCNW----ILSSAIGLPV 202
Cdd:PHA03235  96 GLLSGSVAG---CKFA-SLLYYASCTVGFaTVALIAADRY-RVIHQRTRARSSAYRSTYKILGLTWfaslICSGPAPVYT 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  203 MFMATTKYRQGSID---CTLTFSHPTWYweNLL---KICVFIFAFIMPVLIITVCYGLMILRLKsvrmLSGSKEKDRNLR 276
Cdd:PHA03235 171 TVVAHDDVDPEAPGyetCVIYFRADQVK--TVLstfKVLLTLVWGIAPVVMMTWFYTFFYRTLK----RASYKKRSRTLT 244
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  277 RITRMVLVVVAVFivcwTPihiYVIIKALitipeTTFQTVSWHF-CIALGYTNS------------CL-NPVLYAFLDEN 342
Cdd:PHA03235 245 FVCILLLSFLCLQ----TP---FVAIMIF-----DSYATLIWPSdCEHINLRDAvstlsrlvpnlhCLlNPILYAFLGND 312

                 ....*...
gi 84370244  343 FKRCFREF 350
Cdd:PHA03235 313 FLKRFRQC 320
7tmA_OR13H-like cd15431
olfactory receptor subfamily 13H and related proteins, member of the class A family of ...
69-172 5.46e-06

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320548 [Multi-domain]  Cd Length: 269  Bit Score: 47.60  E-value: 5.46e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGtwpFGTI---LCKIVI 144
Cdd:cd15431   1 IILFVLLLIVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDiCYTTSSVPQMLVNCLSD---RPTIsysRCLAQM 77
                        90       100
                ....*....|....*....|....*...
gi 84370244 145 SIDYYNMFTSIFTLCTMSVDRYIAVCHP 172
Cdd:cd15431  78 YISLFLGITECLLLAVMAYDRFVAICNP 105
7tmA_MC4R cd15353
melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G ...
74-347 8.83e-06

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320475 [Multi-domain]  Cd Length: 269  Bit Score: 47.21  E-value: 8.83e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  74 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSV------NYLMGTWPFGTILCKIVISID 147
Cdd:cd15353   6 VFVTLGIVSLLENILVIAAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETVvitllnGNDTDAQSFTVNIDNVIDSVI 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 148 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGlpVMFMattkyrqgsidctltfshpTWY 227
Cdd:cd15353  86 CSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRAGVIITCIWTACTVSG--VLFI-------------------IYS 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 228 WENLLKICVFIFAFIMPVLIITV---CYGLMILRLKSVRMLSGSKekdrNLRRITRMVLVVVAVF-----IVCWTPIHIY 299
Cdd:cd15353 145 DSSVVIICLISMFFTMLALMASLyvhMFLLARLHIKRIAVLPGTG----PIRQGANMKGAITLTIllgvfVVCWAPFFLH 220
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 84370244 300 VIIkaLITIPETTFQTV---SWHFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15353 221 LIF--YISCPRNPYCVCfmsHFNMYLILIMCNSVIDPLIYAFRSQELRKTF 269
7tmA_MCR cd15103
melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
80-347 8.85e-06

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320231 [Multi-domain]  Cd Length: 270  Bit Score: 47.10  E-value: 8.85e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  80 VVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-------ALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMF 152
Cdd:cd15103  12 IVSLLENILVILAIAKNKNLHSPMYFFICSLAVADmlvsvsnALETIVIILLNNGYLVPRDSFEQHIDNVIDSMICSSLL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 153 TSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGlpVMFMAttkyrqgsidctltFSHPTwywenLL 232
Cdd:cd15103  92 ASICSLLAIAVDRYITIFYALRYHSIMTVRRAGVIITAIWVFCTVCG--ILFII--------------YSDSV-----PV 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 233 KICVFIFAFIMPVLIITVcYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVF-----IVCWTPIHIYVIIkaLIT 307
Cdd:cd15103 151 IICLISMFFAMLVLMASL-YVHMFLLARSHVKKIAALPGQRSTRQRANMKGAVTLTIllgvfIFCWAPFFLHLTL--MIS 227
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 84370244 308 IPETTF---QTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15103 228 CPSNPYcacYMSHFNVYLILIMCNSVIDPLIYAFRSQELRKTF 270
7tmA_GPR150 cd15198
G protein-coupled receptor 150, member of the class A family of seven-transmembrane G ...
69-345 1.04e-05

G protein-coupled receptor 150, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors. Its endogenous ligand is not known. These receptors share a significant amino acid sequence similarity, suggesting that they have a common evolutionary origin.


Pssm-ID: 320326 [Multi-domain]  Cd Length: 299  Bit Score: 47.11  E-value: 1.04e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVcVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATS-TLPFQSVNYLMG-TWPFGTILCKIVISI 146
Cdd:cd15198   2 TRLIFLGVIL-VAGVAGNTTVLCWLCGGRRRKSRMNFLLLQLALADLLVIGgTALSQIIWELLGdRWMAGDVACRLLKLL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 147 DYYNMFTSIFTLCTMSVDRYIAVCHPvkaldFRTPRNAKIVNVCNWILSSAIGLPVMFM-------ATTKYRQGSIDCTL 219
Cdd:cd15198  81 QASARGASANLVVLLALDRHQAIRAP-----LGQPLRAWKLAALGWLLALLLALPQAYVfrvdfpdDPASAWPGHTLCRG 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 220 TFS-HPTWYWENLLkICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRIT------------------R 280
Cdd:cd15198 156 IFApLPRWHLQVYA-TYEAVVGFVAPVVILGVCYGRLLLKWWERANQAPGAKKPWKKPSKShlratapsalprakvktlK 234
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 84370244 281 MVLVVVAVFIVCWTPIHIYVIIKALIT---IPETTFQTVSwhfciALGYTNSCLNPVLYAFLDENFKR 345
Cdd:cd15198 235 MTLVIALLFVGCSLPYFIAELAAAFGSgdwEPEKVAAALG-----VMAVANSATNPFVFLFFNAGDCR 297
7tmA_GPR88-like cd15211
G protein-coupled receptor 88, member of the class A family of seven-transmembrane G ...
74-347 1.09e-05

G protein-coupled receptor 88, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR88, an orphan G protein-coupled receptor, is predominantly and almost exclusively expressed within medium spiny neurons (MSNs) of the brain's striatum in both human and rodents; thus it is also called Striatum-specific GPCR (STRG). The striatum is known to involve in motor coordination, reward-based decision making, and response learning. GPR88 is shown to co-localize with both dopamine D1 and D2 receptors and displays the highest sequence similarity to receptors for biogenic amines such as dopamine and serotonin. GPR88 knockout mice showed abnormal behaviors observed in schizophrenia, such as disrupted sensorimotor gating, increased stereotypic behavior and locomotor activity in response to treatment with dopaminergic compounds such as apomorphine and amphetamine, respectively, suggesting a role for GPR88 in dopaminergic signaling. Furthermore, the transcriptional profiling studies showed that GPR88 expression is altered in a number of psychiatric disorders such as depression, drug addiction, bipolar and schizophrenia, providing further evidence that GPR88 plays an important role in CNS signaling pathways related to psychiatric disorder. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320339 [Multi-domain]  Cd Length: 283  Bit Score: 47.15  E-value: 1.09e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  74 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-----------ALATSTLPFQSVNY------LMGTWpfg 136
Cdd:cd15211   5 VYSFLAVSGTLANVLVIYLVVSFKKLQTTSNAFIVNGCVADllvcafwmpqeAVLGSTGTLLVLGYrlfregLLFLG--- 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 137 tilckivisidyynMFTSIFTLCTMSVDRYIAVCH-PVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATtkYRQGSI 215
Cdd:cd15211  82 --------------LTVSLLSHSLIALNRYVLITKlPAVYQALYQKRNTEWMIALSWALALGLLLPWLTSFR--YPTKSC 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 216 DCTLTFSHPTWYWENLLKICVFI-FAFIMPVLIITVCYgLMILR-----LKSVRMLSGSKEKD-----RNLRRITRMVLV 284
Cdd:cd15211 146 HDSADGSFAVVSVLSSRYPALLLaFTVLGQTALVLHCY-FGIFRrvqisVKRVSVLNFQIVNNlpysrPRKDKRLGLYVL 224
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 84370244 285 VVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALgytnSCLNPVLYAFLDENFKRCF 347
Cdd:cd15211 225 LVCCVFLLTTEPLVWVSLAGLFVPVPVALQTASWLLFCTL----FVLNPFLYTWKNEEFRRSF 283
7tmA_SREB2_GPR85 cd15218
super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of ...
81-219 1.55e-05

super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320346 [Multi-domain]  Cd Length: 330  Bit Score: 46.95  E-value: 1.55e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  81 VGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST-LPFQSVNYLMG-TWPFGTILCKIVISIDYYNMFTSIFTL 158
Cdd:cd15218  13 VSVVGNLLISILLVKDKTLHRAPYYFLLDLCCSDILRSAIcFPFVFTSVKNGsTWTYGTLTCKVIAFLGVLSCFHTAFML 92
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 84370244 159 CTMSVDRYIAVCHP---VKALDFRTPrnakIVNVCN-WILSSAIGL-PVMFMATTKYRQGSIDCTL 219
Cdd:cd15218  93 FCISVTRYLAIAHHrfyTKRLTFWTC----LAVICMvWTLSVAMAFpPVLDVGTYSFIREEDQCTF 154
7tmA_OR2F-like cd15429
olfactory receptor subfamily 2F and related proteins, member of the class A family of ...
73-174 2.05e-05

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320546 [Multi-domain]  Cd Length: 277  Bit Score: 46.24  E-value: 2.05e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  73 ALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMG--TWPFGTILCKIVISIDYY 149
Cdd:cd15429   5 VLFLVMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDiCYTTSVVPQMLAHFLAEhkTISFASCVAQLFISLALG 84
                        90       100
                ....*....|....*....|....*
gi 84370244 150 NmfTSIFTLCTMSVDRYIAVCHPVK 174
Cdd:cd15429  85 G--TEFILLAVMAYDRYVAVCHPLR 107
7tmA_MrgprB cd15107
mas-related G protein-coupled receptor subtype B, member of the class A family of ...
70-338 2.36e-05

mas-related G protein-coupled receptor subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320235  Cd Length: 276  Bit Score: 45.85  E-value: 2.36e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  70 TIMALYSIVCVVGLFGNFLVMYVIVrYTKMKTATNIYIFNLALADALatsTLPFQSVNYLMGTWPFGTILCKIVISIDYY 149
Cdd:cd15107   2 TMNFLSIIIALVGLAGNAIVLWLLG-FHMHRNAFSVYILNLAGADFL---FLCTQIVFSLEIVLQFHSIDIHIPLFLLTV 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 150 NMFTSIFTLC---TMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMfmattkyrqgsIDCTLTFSHPTW 226
Cdd:cd15107  78 TMFAYLAGLSmitAISIERCLSVMWPIWYHCQRPRHTSAVICTLLWVLSLLLSLLEG-----------KGCGFLFSTYDY 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 227 YWenlLKICVFIFAFIMPVLIITVCYGLMILRlksVRMLSGSKEKDrnlrrITRMVLVVVAVF---IVCWTPIHIYVIIK 303
Cdd:cd15107 147 YW---CWTLDLITTAWLIVLFVVLSGSSLALL---VRIFCGSHRIP-----VTRLYVTIALTVlvfLIFGLPFGIYWFLL 215
                       250       260       270
                ....*....|....*....|....*....|....*
gi 84370244 304 ALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAF 338
Cdd:cd15107 216 KWIEEFYIVPCCGFYEVILFLSCVNSCANPIIYFL 250
7tmA_MC5R cd15354
melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...
74-347 2.53e-05

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320476 [Multi-domain]  Cd Length: 270  Bit Score: 45.70  E-value: 2.53e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  74 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVN-YLMGTWP--------------FGTI 138
Cdd:cd15354   6 VFLTLGIISLLENILVILAIVKNKNLHSPMYFFVCSLAVADMLVSVSNAWETITiYLLNNRHlviedafvrhidnvFDSL 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 139 LCKIVISidyynmftSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYrqgsidct 218
Cdd:cd15354  86 ICISVVA--------SMCSLLAIAVDRYVTIFYALRYHNIMTVRRAGIIIACIWTFCTGCGIIFILYSESTY-------- 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 219 ltfshptwywenlLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSgSKEKDRNLRRITRMVLVVVAVF-----IVCW 293
Cdd:cd15354 150 -------------VIICLITMFFAMLFLMVSLYIHMFLLARTHVKRIA-ALPGYNSVRQRTSMKGAVTLTIllgifIVCW 215
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 84370244 294 TPIHIYVIIkaLITIPETTFQTV---SWHFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15354 216 APFFLHLIL--MISCPQNLYCVCfmsHFNMYLILIMCNSVIDPLIYAFRSQEMRKTF 270
7tmA_MC2R_ACTH_R cd15350
melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of ...
74-338 2.67e-05

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320472 [Multi-domain]  Cd Length: 270  Bit Score: 45.54  E-value: 2.67e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  74 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST-------LPFQSVNYLMGTWPFGTILCKIVISI 146
Cdd:cd15350   6 VFFTIAAVGLLENLLVLVAVIKNKNLHSPMYFFICSLAVSDMLGSLYktlenilIILADMGYLNRRGPFETKLDDIMDSL 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 147 DYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFmattkyrqgsidctltFSHptw 226
Cdd:cd15350  86 FCLSLLGSIFSILAIAADRYITIFHALRYHNIMTMRRTLVILAIIWTFCGGSGILMIL----------------FFH--- 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 227 ywENLLKICVFIFAFIMPVLIITVcYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFI-----VCWTPIHIYVI 301
Cdd:cd15350 147 --FVATVICFTVLFFLMLVLILCL-YVHMFLLARSHARKIASLPNHHAQHQRSNMRGAITLTILlgvfvCCWAPFVLHLL 223
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 84370244 302 IKALITI-PETTFQTVSWHFCIALGYTNSCLNPVLYAF 338
Cdd:cd15350 224 LMMFCPMnPYCACYRSLFQVNGTLIMSHAVIDPAIYAF 261
7tmA_OR1_7-like cd15918
olfactory receptor families 1, 7, and related proteins, member of the class A family of ...
80-200 2.92e-05

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320584 [Multi-domain]  Cd Length: 270  Bit Score: 45.68  E-value: 2.92e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  80 VVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATS-TLPFQSVNYLMG--TWPFGTILCKIVISIDYYNMftSIF 156
Cdd:cd15918  12 LVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTStTVPKMLVNIQTQskSISYAGCLTQMYFFLLFGDL--DNF 89
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 84370244 157 TLCTMSVDRYIAVCHPVK-ALDFRTPRNAKIVNVCnWILSSAIGL 200
Cdd:cd15918  90 LLAVMAYDRYVAICHPLHyTTIMSPRLCILLVAAS-WVITNLHSL 133
7tmA_MC1R cd15351
melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...
74-345 4.65e-05

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320473 [Multi-domain]  Cd Length: 271  Bit Score: 44.78  E-value: 4.65e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  74 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALA-------TSTLPFQSVNYLMGTWPFGTILCKIVISI 146
Cdd:cd15351   6 LFLFLGLVSLVENILVVVAIAKNRNLHSPMYYFICCLAVSDMLVsvsnlieTLFMLLLEHGVLVCRAPMLQHMDNVIDTM 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 147 DYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAiglpvmfmattkyrqgsidCTLTFShpTW 226
Cdd:cd15351  86 ICSSVVSSLSFLGAIAVDRYITIFYALRYHSIMTLQRAVNAIAGIWLASTV-------------------SSTLFI--VY 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 227 YWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVF-----IVCWTPIHIYVI 301
Cdd:cd15351 145 YNSNAVILCLIVFFLFMLVLMLVLYIHMFILACRHSQSISSQQRRQCPHQQTASLKGAITLTIllgifFLCWGPFFLHLT 224
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 84370244 302 IkaLITIPETTFQTVSW-HFCI--ALGYTNSCLNPVLYAFLDENFKR 345
Cdd:cd15351 225 L--IVTCPTHPFCLCYFkYFNLflILIICNSIIDPLIYAFRSQELRK 269
7tmA_MrgprX-like cd15106
primate-specific mas-related G protein-coupled receptor subtype X-like, member of the class A ...
69-339 5.66e-05

primate-specific mas-related G protein-coupled receptor subtype X-like, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320234  Cd Length: 274  Bit Score: 44.74  E-value: 5.66e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIvRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGtwPFGTI-LCKIVISID 147
Cdd:cd15106   1 LSLTFLTCIISLVGLTGNAVVLWLL-GFRMRRNAFSVYILNLAAADFLFLCCHIIDSLLRLIN--IFHIIsIPKILTNVM 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 148 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIG-LPVMFMattkyrqgsiDCTLTFSHPTW 226
Cdd:cd15106  78 TFPYFAGLSMLSAISTERCLSVLWPIWYRCHRPRHLSAVVCVLLWALSLLLSiLEWKFC----------GFLFSGADSHW 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 227 yWENLlkicVFIFAFIMPVLIITVCYGLMILRlksVRMLSGSKEKDrnLRRITRMVLVVVAVFIVCWTPIHIYViikALI 306
Cdd:cd15106 148 -CQTF----DFITTAWLIFLFVVLCGSSLALL---VRILCGSRKMP--LTRLYVTILLTVLVFLLCGLPFGIQW---FLL 214
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 84370244 307 TIPETTFQTVSWHFCIA---LGYTNSCLNPVLYAFL 339
Cdd:cd15106 215 LWIHIDLEVLFCHVYLVsvvLSCLNSSANPIIYFFV 250
7tmA_Cannabinoid_R cd15099
cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled ...
72-337 6.04e-05

cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320227 [Multi-domain]  Cd Length: 281  Bit Score: 44.83  E-value: 6.04e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  72 MALYSIVCVVGLFG---NFLVMYVIVRYTKMK-TATNIYIFNLALADALATSTLPFQSVNYlmgtwpfgtilcKIVISID 147
Cdd:cd15099   1 KAIAVLCFLAGPVTfleNILVLLTILSSTALRrRPSYLFIGSLALADMLASVIFTISFLDF------------HVFHQRD 68
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 148 YYNMF-------TSIFT-----LCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIG-LPVMFMATTKYRQgs 214
Cdd:cd15099  69 SRNLFlfklggvTMAFTasvgsLLLTALDRYLCIYQPSNYKLLVTRTRAKVAILLMWCVTIIISfLPLMGWRCKTWDS-- 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 215 iDCTLTFSH-PTWYWENLLKICVFIFAFIMpvliitVCYGLMILRLKS-VRMLSGSKEKDRNLRRITRM---------VL 283
Cdd:cd15099 147 -PCSRLFPYiDRHYLASWTGLQLVLLFLII------YAYPYILWKAHRhEANMGGPKLGRQQVKGQARMrmdirlaktLS 219
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 84370244 284 VVVAVFIVCWTPIHIYVIIKALITIpeTTFQTVSWHFCIALGYTNSCLNPVLYA 337
Cdd:cd15099 220 LILLVLAICWLPVLAFMLVDVRVTL--TNKQKRMFAFCSMLCLVNSCVNPIIYA 271
7tmA_OR2A-like cd15420
olfactory receptor subfamily 2A and related proteins, member of the class A family of ...
73-206 6.82e-05

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320542 [Multi-domain]  Cd Length: 277  Bit Score: 44.63  E-value: 6.82e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  73 ALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNM 151
Cdd:cd15420   5 GLFSLLYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDiCYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFLALA 84
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 84370244 152 FTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMA 206
Cdd:cd15420  85 HTECVLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLL 139
7tmA_GPR142 cd15129
G-protein-coupled receptor GPR142, member of the class A family of seven-transmembrane G ...
75-345 6.90e-05

G-protein-coupled receptor GPR142, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR142, a vertebrate orphan receptor, is very closely related to GPR139, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and plays an important role in mediating enhancement of glucose-stimulated insulin secretion and maintaining glucose homeostasis, whereas GPR139 is expressed almost exclusively in the brain and is suggested to play a role in the control of locomotor activity. These orphan receptors are phylogenetically clustered with invertebrate FMRFamide receptors such as Drosophila melanogaster DrmFMRFa-R.


Pssm-ID: 320257 [Multi-domain]  Cd Length: 270  Bit Score: 44.38  E-value: 6.90e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  75 YSIVCVVGLFGNFLVMYVIVRY-TKMKTATNIYIFNLALADALATSTLPFqsVNYLMGTWPFG----TILCKIVISIDYY 149
Cdd:cd15129   7 YSVLLCLGLPVNILTAVALSRLaVRTKKSSYYYLLALTASDILTQVFIIF--VGFILQTAILArevpHALIHTVSVLEFA 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 150 NMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMF---MATTKYRQGSIDCTLTFSHptw 226
Cdd:cd15129  85 ANHASIWITVLLTVDRYVALCHPLRYRAVSYPERTRRIIAAVFVAALATGIPFYWwsdMWRDSHPPTTLDKVLKWTH--- 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 227 ywenllkicVFIFAFImPVLIITVCYGLMILRLksvRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPiHIYVIIKALI 306
Cdd:cd15129 162 ---------CFIIYFI-PCTIFLVTNSVIIHKL---RRRKGRSGPQRRSGKTTAILLAITTVFAVLWAP-RTVVIIYHLY 227
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 84370244 307 TIPETTFQTVSWHFCIA--LGYTNSCLNPVLYAFLDENFKR 345
Cdd:cd15129 228 VSSVNRDWRVHLALDLAnmLAMLNTAVNFFLYCFVSKRFRR 268
7tmA_CB2 cd15341
cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G ...
69-338 9.20e-05

cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320463 [Multi-domain]  Cd Length: 279  Bit Score: 44.06  E-value: 9.20e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKM-KTATNIYIFNLALADALATSTLPFQSVNY--LMGTWPFGTILCKIvis 145
Cdd:cd15341   1 IAIAVLCTLCGLLCILENVAVLYLILSSPKLrRKPSYLFIGSLALADFLASVVFACSFVDFhvFHGVDSSAIFLLKL--- 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 146 iDYYNM-FT-SIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIG-LPVMFMATTkyrQGSIDCTLTFs 222
Cdd:cd15341  78 -GGVTMsFTaSLGSLLLMAFDRYVCIYYPSEYKALVTRKRALVALAVMWVLTALIAyLPLMGWNCC---PLNSPCSELF- 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 223 hPTWYWENLLKICVFIfAFIMPVLIITVCYGLMILRLKSVRMlsgSKEKDRNLRRITRM---------VLVVVAVFIVCW 293
Cdd:cd15341 153 -PLIPNDYLLSWLLLV-AILLSGIIYTYGHVLWKAHKHVVYM---EKHQDQQGPGNARMrldvrlaktLGLVLAVLLICW 227
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 84370244 294 TPIHIYVIIKALITIPETTFQTVSwhFCIALGYTNSCLNPVLYAF 338
Cdd:cd15341 228 SPVLALMMHSLFTSLSDHIKKAFA--FCSTLCLVNSMVNPIIYAL 270
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
74-172 1.11e-04

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 43.79  E-value: 1.11e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  74 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST-LPFQSVNYLMG--TWPFGTILCKIVISIdyYN 150
Cdd:cd15232   6 LFLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTvVPKLLQNLLTErkTISFGGCMAQLYFFT--WS 83
                        90       100
                ....*....|....*....|..
gi 84370244 151 MFTSIFTLCTMSVDRYIAVCHP 172
Cdd:cd15232  84 LGSELLLLTAMAYDRYVAICHP 105
7tmA_S1PR1_Edg1 cd15346
sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial ...
74-347 1.12e-04

sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial differentiation gene 1 (Edg1), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320468 [Multi-domain]  Cd Length: 277  Bit Score: 43.71  E-value: 1.12e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  74 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLpfqSVNYLMgTWPFGTILCKIVISIDYYNMFT 153
Cdd:cd15346   6 VFIIICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAY---TANLLL-SGATTYKLTPTQWFLREGSMFV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 154 ----SIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCnWILSSAIG-LPVMFMATTKYRQgsiDCTLTFShptWYW 228
Cdd:cd15346  82 alsaSVFSLLAIAIERYITMLKMKLHNGSNSFRSFLLISAC-WVISLILGgLPIMGWNCISALS---SCSTVLP---LYH 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 229 ENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRM-----LSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIK 303
Cdd:cd15346 155 KHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLtfrknIRKASRSSEKSMALLKTVIIVLSVFIACWAPLFILLLLD 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 84370244 304 ALITIPETTFQTVSWHFcIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15346 235 VGCKVKTCSILFKAEYF-LVLAVLNSATNPIIYTLTNKEMRRAF 277
7tmA_FSH-R cd15360
follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G ...
154-347 1.21e-04

follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. FSH-R functions in gonad development and is found in the ovary, testis, and uterus. Defects in this receptor cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. The FSH-R activation couples to the G(s)-protein and stimulates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320482  Cd Length: 275  Bit Score: 43.69  E-value: 1.21e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 154 SIFTLCTMSVDRYIAVCHPVKaLDFRTP-RNAKIVNVCNWILSSAIGLPVMFmATTKYRQGSIDCTLTFSHPtwywenlL 232
Cdd:cd15360  94 SVYTLTVITLERWHTITYAMQ-LDRKVRlRHAAVIMVGGWIFAFTVALLPIF-GISSYMKVSICLPMDIESP-------L 164
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 233 KICVFIFAFIMPVL---IITVCYGLMILRLKSVRMLSGSKEKdrnlrRITRMVLVVVAVFIVCWTPIHIYVIIKA----L 305
Cdd:cd15360 165 SQAYIIFILVLNVLaflIICACYIKIYLTVRNPNFVSSNSDT-----KIAKRMAVLIFTDFLCMAPISFFAISASlkvpL 239
                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 84370244 306 ITIPETTFQTVSWHfcialgYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15360 240 ITVSKSKILLVLFY------PINSCANPFLYAIFTKTFRRDF 275
7tmA_ETBR-LP2 cd15126
endothelin B receptor-like protein 2, member of the class A family of seven-transmembrane G ...
71-172 1.86e-04

endothelin B receptor-like protein 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelin B receptor-like protein 2, also called GPR37L1, is almost exclusively expressed in the nervous system. It has recently been shown to act as a receptor for the neuropeptide prosaptide, the active fragment of the secreted neuroprotective and glioprotective factor prosaposin (also called sulfated glycoprotein-1). Both prosaptide and prosaposin protect primary astrocytes against oxidative stress. GPR37L1 is part of the class A family of GPCRs that includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320254  Cd Length: 298  Bit Score: 43.32  E-value: 1.86e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  71 IMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATS-TLPFQSVNYLMGTWPFGTILCKIVISIDYY 149
Cdd:cd15126   3 ILLLALVVFAVGIVGNLSVMCIVWHSYYLKSAWNSILASLALWDFLVLFfCLPVVVFNEITKKRLLGDVSCRVVPYMEVT 82
                        90       100
                ....*....|....*....|...
gi 84370244 150 NMFTSIFTLCTMSVDRYIAVCHP 172
Cdd:cd15126  83 SLGVTTFSLCALGIDRFHAATSP 105
7tmA_OR52R_52L-like cd15951
olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...
77-174 2.52e-04

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320617  Cd Length: 275  Bit Score: 42.72  E-value: 2.52e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  77 IVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCkiVISIDYYNMFTSI 155
Cdd:cd15951   9 IMYAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDlVLSTSTLPKMLSIFWFNSREIDFSAC--LTQMFFIHSFSTM 86
                        90       100
                ....*....|....*....|.
gi 84370244 156 FT--LCTMSVDRYIAVCHPVK 174
Cdd:cd15951  87 ESgiFVAMALDRYVAICNPLR 107
7tmA_S1PR4_Edg6 cd15349
sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial ...
86-338 3.57e-04

sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial differentiation gene 6 (Edg6), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320471 [Multi-domain]  Cd Length: 271  Bit Score: 42.08  E-value: 3.57e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  86 NFLVMYVIVRYTKMKTATNIYIFNLALADALA-TSTLpfqsVNYLMG---TWPFGTILCKIVISIDYYNMFTSIFTLCTM 161
Cdd:cd15349  18 NLLVLLAILRRVRLRRWVYICLANIALSDLLTgTSYL----VNICLSgerTFRLTPALWFLREGLLFTALAASTFSLLVT 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 162 SVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIG-LPVM-FMATTKYRQGSIDCTLtfshptwYWENLLKICVFIF 239
Cdd:cd15349  94 AVERYATMVRPVAENTATKTYRVYGMIVLCWILAFLIGfLPLLgWNCLCDFRSCSSLLPL-------YSKSYILFCLVIF 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 240 AFIMpvLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITiPETTFQTVSWH 319
Cdd:cd15349 167 FIIL--LTIIGLYFAIYCLVRASGQRVISARSRRRSLRLLKTVLMILGAFMVCWGPLFILLLVDFFCS-SRSCKPLFGME 243
                       250
                ....*....|....*....
gi 84370244 320 FCIALGYTNSCLNPVLYAF 338
Cdd:cd15349 244 WVLALAVLNSAINPLIYSF 262
7tmA_OR1A-like cd15235
olfactory receptor subfamily 1A and related proteins, member of the class A family of ...
73-200 3.74e-04

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320363 [Multi-domain]  Cd Length: 278  Bit Score: 42.21  E-value: 3.74e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  73 ALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTW--PFGTILCKIVISIDYY 149
Cdd:cd15235   6 LLFLAMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDiCFTSTTVPKMLANLLSGSKtiSYAGCLAQMYFFIAFG 85
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 84370244 150 NMFTsiFTLCTMSVDRYIAVCHPVKALDFRTPRN-AKIVNVCnWILSSAIGL 200
Cdd:cd15235  86 NTDS--FLLAVMAYDRYVAICHPLHYATVMSPKRcLLLVAGS-WLLSHLHSL 134
7tmA_LHCGR cd15359
luteinizing hormone-choriogonadotropin receptor, member of the class A family of ...
80-347 4.83e-04

luteinizing hormone-choriogonadotropin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. LHCGR is expressed predominantly in the ovary and testis, and plays an essential role in sexual development and reproductive processes. LHCGR couples primarily to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320481 [Multi-domain]  Cd Length: 275  Bit Score: 41.77  E-value: 4.83e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  80 VVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD----------ALATSTLPFQSVNYLMgTWPFGTiLCKIVISIDYY 149
Cdd:cd15359  12 ILAIAGNLIVLFVLLTSRYKLTVPRFLMCNLSFADfcmglyllliASVDSQTKSQYYNHAI-DWQTGS-GCSTAGFFTVF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 150 NMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLpVMFMATTKYRQGSIDCTLTFSHPTWYWE 229
Cdd:cd15359  90 ASELSVYTLTVITLERWHTITYAMQLDRKLRLRHAILIMLGGWVFSLLIAV-LPLVGVSNYMKVSICLPMDIETLLSQAY 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 230 NLLKICVFIFAFimpvLIITVCYGLMILRLKSVRMLSGSKEKdrnlrRITRMVLVVVAVFIVCWTPIHIYVIiKALITIP 309
Cdd:cd15359 169 ILLILVLNVIAF----LVICACYIKIYLAVQNPELVAKNKDT-----KIAKRMAILIFTDFTCMAPISFFAI-SAAFKVP 238
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 84370244 310 ETTFqTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15359 239 LITV-TNSKILLVLFYPINSCANPFLYAIFTKAFRRDF 275
7tmA_GPR176 cd15006
orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; ...
77-346 6.56e-04

orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; GPR176 is a putative G protein-coupled receptor that belongs to the class A GPCR superfamily; no endogenous ligand for GPR176 has yet been identified. The class A rhodopsin-like GPCRs represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320135 [Multi-domain]  Cd Length: 289  Bit Score: 41.40  E-value: 6.56e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  77 IVCVVG-LFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST-LPFQ---SVNYLMGTWPFGTILCKIVISIDYYNM 151
Cdd:cd15006   7 VVIFVGsLLGNFMVLWSTCRTSVFKSVTNRFIKNLACSGICASLVcVPFDivlSASPHCCWWIYTLLFCKVIKFLHKVFC 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 152 FTSIFTLCTMSVDRYIAVCHPVKaldfRTPRNAKIVNVCNWILSSAI--GLPVMFMATTKYRQGSIDCTLTFSHPTWYWe 229
Cdd:cd15006  87 SVTVLSFAAIALDRYYSVLYPLE----RKISDAKSRDLVIYIWAHAVvaSVPVFAVTNVTDIYAMSTCTESWGYSLGHL- 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 230 nllkICVFIFAFIMPVLIITVCYGLMILrlkSVRMLSGSKEK-------------------DRNLRRITRMVLVVVAVFI 290
Cdd:cd15006 162 ----VYVIIYNITTVILPVAVVFLFMIL---IRRALSASQKKkviiaalrtpqntisipyvSQREAELHAMLLSMVLVFI 234
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 84370244 291 VCWTPIHIYVIIKALITIPETT---FQTVSWHFCIALgytnsCLNPVLYAFLDENFKRC 346
Cdd:cd15006 235 LCSVPYATLVIYRTILNISDISvflLLTAIWLPKVSL-----LANPLLFLTVNKSVRKC 288
7tmA_S1PR cd15102
sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...
73-347 7.45e-04

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320230 [Multi-domain]  Cd Length: 270  Bit Score: 41.30  E-value: 7.45e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  73 ALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALAtstlpfqSVNYLMGTWPFGTILCKIVISIDYY--- 149
Cdd:cd15102   5 VVFVAICCFIVLENLLVLIAIWRHMKFHRPMYYFLGNLALSDLLA-------GAAYLANILLSGARTLRLSPAQWFLreg 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 150 NMFT----SIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCnWILSSAIG-LPVMfmattkyrqgSIDCTLTFSHP 224
Cdd:cd15102  78 SMFValsaSVFSLLAIAIERHLTMAKMKPYGASKTSRVLLLIGAC-WLISLLLGgLPIL----------GWNCLGALDAC 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 225 T----WYWENLLKICVFIFAFIMpvLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYV 300
Cdd:cd15102 147 StvlpLYSKHYVLFCVTIFAGIL--AAIVALYARIYCLVRASGRKATRASASPRSLALLKTVLIVLLVFIACWGPLFILL 224
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 84370244 301 IIKALITIPETTFqTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15102 225 LLDVACPVKTCPI-LYKADWFLALAVLNSALNPIIYTLRSRELRRAV 270
7tmA_OR13-like cd15430
olfactory receptor family 13 and related proteins, member of the class A family of ...
69-174 8.97e-04

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320547 [Multi-domain]  Cd Length: 270  Bit Score: 40.82  E-value: 8.97e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST-LPFQSVNYLMGTWPFGTILCKIVISID 147
Cdd:cd15430   1 ILLFVLCLIMYLVILLGNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSsVPLMLVNFLSERKTISFSGCAVQMYLS 80
                        90       100
                ....*....|....*....|....*..
gi 84370244 148 YYNMFTSIFTLCTMSVDRYIAVCHPVK 174
Cdd:cd15430  81 LAMGSTECVLLAVMAYDRYVAICNPLR 107
7tmA_OR14-like cd15227
olfactory receptor family 14 and related proteins, member of the class A family of ...
73-172 1.23e-03

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320355  Cd Length: 270  Bit Score: 40.51  E-value: 1.23e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  73 ALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATS-TLPFQSVNYLMGTWpfgtilckiviSIDYYN- 150
Cdd:cd15227   5 VLFLLIYLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISvTVPKSIANSLTNTR-----------SISFLGc 73
                        90       100       110
                ....*....|....*....|....*....|..
gi 84370244 151 ----------MFTSIFTLCTMSVDRYIAVCHP 172
Cdd:cd15227  74 vaqvflfiffAASELALLTVMAYDRYVAICHP 105
7tmA_OR2D-like cd15428
olfactory receptor subfamily 2D and related proteins, member of the class A family of ...
69-174 1.35e-03

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320545 [Multi-domain]  Cd Length: 277  Bit Score: 40.54  E-value: 1.35e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMG---TWPFgtILCKIVIS 145
Cdd:cd15428   1 ILLFILFLIIYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSerkIISF--IRCAAQLY 78
                        90       100
                ....*....|....*....|....*....
gi 84370244 146 IDYYNMFTSIFTLCTMSVDRYIAVCHPVK 174
Cdd:cd15428  79 FFLSFGITECALLSVMSYDRYVAICLPLR 107
7tmA_OR5P-like cd15416
olfactory receptor subfamily 5P and related proteins, member of the class A family of ...
69-172 2.03e-03

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320538 [Multi-domain]  Cd Length: 279  Bit Score: 40.04  E-value: 2.03e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCKIVISID 147
Cdd:cd15416   1 IILFVLFLVIYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDiCYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSA 80
                        90       100
                ....*....|....*....|....*
gi 84370244 148 YYNMFTSIFTLCTMSVDRYIAVCHP 172
Cdd:cd15416  81 ATFGTVECFLLAAMAYDRYVAICNP 105
7tmA_OR2-like cd15237
olfactory receptor family 2 and related proteins, member of the class A family of ...
69-172 2.70e-03

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320365 [Multi-domain]  Cd Length: 270  Bit Score: 39.57  E-value: 2.70e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMG--TWPFGTILCKIVIS 145
Cdd:cd15237   1 ILLFILFLLIYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDiCYTTSTVPQMLVHLLSEhkTISFVGCAAQMFFF 80
                        90       100
                ....*....|....*....|....*..
gi 84370244 146 IDYynMFTSIFTLCTMSVDRYIAVCHP 172
Cdd:cd15237  81 LAL--GVTECVLLAVMAYDRYVAICNP 105
7tmA_TSH-R cd15964
thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family ...
78-345 2.88e-03

thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. TSH-R plays an important role thyroid physiology, and its activation stimulates the production of thyroxine (T4) and triiodothyronine (T3). Defects in TSH-R are a cause of several types of hyperthyroidism. The receptor is predominantly found on the surface of the thyroid epithelial cells and couples to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production. TSH and cAMP stimulate thyroid cell proliferation, differentiation, and function.


Pssm-ID: 320630 [Multi-domain]  Cd Length: 275  Bit Score: 39.50  E-value: 2.88e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  78 VCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADalatstlpfqsvnYLMGTWPFGTILCKIVISIDYYN------- 150
Cdd:cd15964  10 VNLLAILGNVFVLLILLTSHYKLTVPRFLMCNLAFAD-------------FCMGIYLLLIASVDLHTRSEYYNhaidwqt 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 151 --------MFT------SIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLpVMFMATTKYRQGSID 216
Cdd:cd15964  77 gpgcntagFFTvfaselSVYTLTVITLERWYAITFAMRLDRKIRLRHASAIMLGGWVFCFLLAL-LPLVGVSSYAKVSIC 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 217 CTLTFSHPTWYWENLLKICVFIFAFImpvlIITVCYGLMILRLKSVRMLSGSKEKdrnlrRITRMVLVVVAVFIVCWTPI 296
Cdd:cd15964 156 LPMDTETPLAQAYIVFVLMLNIIAFV----IICACYIKIYITVRNPQYKSGDKDT-----KIAKRMAVLIFTDFICMAPI 226
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 84370244 297 HIY----VIIKALITIPETTFQTVSWHfcialgYTNSCLNPVLYAFLDENFKR 345
Cdd:cd15964 227 SFYalsaILNKPLITVSNSKILLVLFY------PLNSCANPFLYAIFTKAFRR 273
7tmA_MrgprH cd15110
mas-related G protein-coupled receptor subtype H, member of the class A family of ...
77-349 2.93e-03

mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320238  Cd Length: 274  Bit Score: 39.31  E-value: 2.93e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  77 IVCVVGLFGNFLVMYVIVRYTKMKTATnIYIFNLALADALATSTLPFQSVNYLMG---TWPFGTILCKIVISIDYYNMFT 153
Cdd:cd15110   9 IICLLGLVGNGIVLWFLGFRIRRNPFT-VYILHLAIADFTFLLCIFILSIMYIGPfnfSHSRDYVAMLIFIILFLFGYNT 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 154 SIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSsaiglpvMFMATTKYrqgsIDCTLTFSHPTWYwenllk 233
Cdd:cd15110  88 GLYLLTAISVERCLSVLYPIWYRCHRPKHQSAIVCGLLWALS-------VLMTSLEY----LMCIDEGFHVRNE------ 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 234 iCVFIFAFIMpVLIITVCYGLMILRLKS--VRMLSGSKEkdrnlRRITRMvlvvvavfivcWTPIHIYVIIKALITIP-- 309
Cdd:cd15110 151 -CRAVLIFIG-ILTFLVFTPLMLISSLIlfIKVRCNSQR-----RHPGKL-----------YIIIMLTVIFFLIFAMPmr 212
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 84370244 310 --------ETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFRE 349
Cdd:cd15110 213 vllllnylHHSSFLFSNPVPFLLSTVNSSINPIVYFLVGSLRRKRIKK 260
7tmA_GPR12 cd15961
G protein-coupled receptor 12, member of the class A family of seven-transmembrane G ...
86-347 2.98e-03

G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320627 [Multi-domain]  Cd Length: 268  Bit Score: 39.24  E-value: 2.98e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  86 NFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSV-NYLMGTWPFGTILCKIVISidyyNMFTSIFTLCTMSVD 164
Cdd:cd15961  18 NAIVVLIIFQNPSLRAPMFLLIGSLALADLLAGIGLILNFIfAYLLQSEAAKLVTVGLIVA----SFSASVCSLLAITVD 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 165 RYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGL-PVMFMATTKYrqgsiDCTLTFSHPTWYWENLLKICVFIFAF-I 242
Cdd:cd15961  94 RYLSLYYALTYNSERTVTFTYVMLVLLWGASICLGLlPVMGWNCLAD-----ESTCSVVRPLTKNNAAILSVSFLLMFaL 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 243 MPVLIITVCYglMILRLKSVRMLSG---SKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVswh 319
Cdd:cd15961 169 MLQLYIQICK--IVMRHAHQIALQHhflATSHYVTTRKGVSTLAIILGTFAACWMPFTLYSLIADYTYPSIYTYATL--- 243
                       250       260
                ....*....|....*....|....*...
gi 84370244 320 fcIALGYtNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15961 244 --LPATY-NSIINPVIYAFRNQEIQKAL 268
7tmA_OR4E-like cd15940
olfactory receptor 4E and related proteins, member of the class A family of ...
69-196 3.41e-03

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320606 [Multi-domain]  Cd Length: 267  Bit Score: 39.35  E-value: 3.41e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  69 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMG--TWPFGtilcKIVIS 145
Cdd:cd15940   1 LAFFMLFLVLYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDIChSSVTVPKMLSDLLSEekTISFN----GCVTQ 76
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 84370244 146 IDYYNMF--TSIFTLCTMSVDRYIAVCHPvkaLDFRTPRNAKivnVCNWILSS 196
Cdd:cd15940  77 LFFLHLFacTEIFLLTIMAYDRYVAICNP---LHYPTVMNHK---VCLWLVAA 123
7tmA_OR52I-like cd15950
olfactory receptor subfamily 52I and related proteins, member of the class A family of ...
74-207 3.88e-03

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320616  Cd Length: 275  Bit Score: 38.93  E-value: 3.88e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  74 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPfqsvnYLMGTWPFGTIlckiviSIDYYNMF 152
Cdd:cd15950   6 PFCSMYVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDlVMSTSIVP-----KMLSIFWLGSA------EISFEACF 74
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 84370244 153 TSIF-----------TLCTMSVDRYIAVCHPVKALDFRTPRnaKIVNVCNWILSSAIGL--PVMFMAT 207
Cdd:cd15950  75 TQMFfvhsftavesgVLLAMAFDRYVAICHPLRYSAILTSQ--VIAQIGLAIVLRALLFmtPLTCLVT 140
7tmA_S1PR2_Edg5 cd15347
sphingosine-1-phosphate receptor subtype 2 (S1PR2 or S1P2), also called endothelial ...
71-347 7.46e-03

sphingosine-1-phosphate receptor subtype 2 (S1PR2 or S1P2), also called endothelial differentiation gene 5 (Edg5), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320469 [Multi-domain]  Cd Length: 266  Bit Score: 38.26  E-value: 7.46e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  71 IMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTlpFQSVNYLMGTWPFGTILCKIVI--SIDY 148
Cdd:cd15347   3 ASIFIVILCCIIVLENLLVLIAVARNKKFHSAMFFFIGNLAFSDLLAGVA--FIANILLSGSVTFRLTPVQWFIreGTAF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 149 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCnWILSSAI-GLPVMFMATTKYRQgsiDCTLTFShptWY 227
Cdd:cd15347  81 ITLSASVFSLLAIAIERHVAITKVKLYGSDKNCRMVLLIGAC-WVISIVLgGLPILGWNCIGNLE---DCSTVLP---LY 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 228 WENLLKICVFIFAFIMpvLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITrmvlVVVAVFIVCWTPIHIYVIIKALIT 307
Cdd:cd15347 154 SKHYILFVVTIFSIIL--LSIVILYVRIYCIVRSSHAEMAAPQTLALLKTVT----IVLGVFIVCWLPAFIILLLDTSCK 227
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 84370244 308 IPETTFQTVSwHFCIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15347 228 VKSCPILYKA-DYFFSVATLNSALNPVIYTLRSKDMRKEF 266
7tmA_OR5H-like cd15409
olfactory receptor subfamily 5H and related proteins, member of the class A family of ...
74-172 8.34e-03

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320531 [Multi-domain]  Cd Length: 279  Bit Score: 38.16  E-value: 8.34e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  74 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADA-LATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMF 152
Cdd:cd15409   6 VFLAIYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADAcTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFFGFSAT 85
                        90       100
                ....*....|....*....|
gi 84370244 153 TSIFTLCTMSVDRYIAVCHP 172
Cdd:cd15409  86 TECFLLAAMAYDRYVAICNP 105
7tmA_S1PR3_Edg3 cd15345
sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial ...
73-347 9.41e-03

sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial differentiation gene 3 (Edg3), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320467 [Multi-domain]  Cd Length: 270  Bit Score: 37.88  E-value: 9.41e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  73 ALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLpfqSVNYLM-GTWPFGtiLCKIVISIDYYNM 151
Cdd:cd15345   5 IFFLVICSFIVLENLMVLIAIWKNNRFHNRMYFFIGNLALCDLLAGIAY---KVNILMsGKKTFS--LSPTQWFLREGSM 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 152 F----TSIFTLCTMSVDRYIAVchpVKALDFRTPRNAKI---VNVCnWILSSAIG-LPVMFMATTKYRQgsiDCTLTFSh 223
Cdd:cd15345  80 FvalgASTFSLLAIAIERHLTM---IKMRPYDANKRYRVfllIGTC-WLISVLLGaLPILGWNCLDNLP---DCSTILP- 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244 224 ptWYWENLLKICVFIFAFIMpvLIITVCYG-LMILRLKSVRMLSGSKEKDRNLRrITRMVLVVVAVFIVCWTPIHIYVII 302
Cdd:cd15345 152 --LYSKKYVAFCISIFIAIL--VAIVILYArIYILVKSSSRRVTNHRNSERSMA-LLRTVVIVVGVFIACWSPLFILLLI 226
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 84370244 303 KALITIPE-TTFQTVSWHfcIALGYTNSCLNPVLYAFLDENFKRCF 347
Cdd:cd15345 227 DVACEVKQcPILYKADWF--IALAVLNSAMNPIIYTLASKEMRRAF 270
7tmA_OR10D-like cd15228
olfactory receptor subfamily 10D and related proteins, member of the class A family of ...
83-224 9.59e-03

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320356 [Multi-domain]  Cd Length: 275  Bit Score: 37.80  E-value: 9.59e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370244  83 LFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPfgTILCKIVISIDYYNMF---TSIFTLC 159
Cdd:cd15228  15 LLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSR--VISLGGCMSQVFFYHFlgsTECLLYT 92
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 84370244 160 TMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAiglpvmfmattkyrQGSIDCTLTFSHP 224
Cdd:cd15228  93 VMAYDRYVAICHPLRYLLIMNRRVCALLAAGTWITSSF--------------HATILTSLTFTLP 143
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH
HHS Vulnerability Disclosure