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Conserved domains on  [gi|85724844|ref|NP_001033855|]
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histone gene-specific epigenetic repressor in late S phase, isoform D [Drosophila melanogaster]

Protein Classification

BAH_BAHCC1 domain-containing protein( domain architecture ID 10140545)

BAH_BAHCC1 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BAH_BAHCC1 cd04714
BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. ...
 1293-1446 2.30e-55

BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the remodeling of chromatin. It is assumed that in most or all of these instances the BAH domain mediates protein-protein interactions.


:

Pssm-ID: 240065  Cd Length: 121  Bit Score: 187.99  E-value: 2.30e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85724844 1293 GDIIRIRDCVLLKANEDNELPYVAKVAHLWQNPEdGEMMMSLLWYYRPEHTDQGRQRNDCPDEVYASRHRDHNSVACVED 1372
Cdd:cd04714    1 KEIIRVGDCVLFKSPGRPSLPYVARIESLWEDPE-GNMVVRVKWYYRPEETKGGRKPNHGEKELFASDHQDENSVQTIEH 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 85724844 1373 KCYVLTFSEYCRYRRRLRaaeedvedvsivprrpsiatapgfpvrtvpehTNPELVMFCRRAYEFRTRRLLKLP 1446
Cdd:cd04714   80 KCYVLTFAEYERLARVKK--------------------------------KPQDGVDFYYCAGTYNPDTGMLKC 121
 
Name Accession Description Interval E-value
BAH_BAHCC1 cd04714
BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. ...
 1293-1446 2.30e-55

BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the remodeling of chromatin. It is assumed that in most or all of these instances the BAH domain mediates protein-protein interactions.


Pssm-ID: 240065  Cd Length: 121  Bit Score: 187.99  E-value: 2.30e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85724844 1293 GDIIRIRDCVLLKANEDNELPYVAKVAHLWQNPEdGEMMMSLLWYYRPEHTDQGRQRNDCPDEVYASRHRDHNSVACVED 1372
Cdd:cd04714    1 KEIIRVGDCVLFKSPGRPSLPYVARIESLWEDPE-GNMVVRVKWYYRPEETKGGRKPNHGEKELFASDHQDENSVQTIEH 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 85724844 1373 KCYVLTFSEYCRYRRRLRaaeedvedvsivprrpsiatapgfpvrtvpehTNPELVMFCRRAYEFRTRRLLKLP 1446
Cdd:cd04714   80 KCYVLTFAEYERLARVKK--------------------------------KPQDGVDFYYCAGTYNPDTGMLKC 121
BAH smart00439
Bromo adjacent homology domain;
1295-1446 1.64e-19

Bromo adjacent homology domain;


Pssm-ID: 214664 [Multi-domain]  Cd Length: 121  Bit Score: 85.81  E-value: 1.64e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85724844    1295 IIRIRDCVLLKANEDNELPYVAKVAHLWQNPEDGEMMMSLL-WYYRPEHTDQGRQRNDCPDEVYASRHRDHNSVACVEDK 1373
Cdd:smart00439    1 TISVGDFVLVEPDDADEPYYIGRIEEIFETKKNSESKMVRVrWFYRPEETVLEKAALFDKNEVFLSDEYDTVPLSDIIGK 80

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 85724844    1374 CYVLTFSEYCRYRRRLRAAEEDVedvsivprrpsiatapgFpvrtvpehtnpelvmFCRRAYEFRTRRLLKLP 1446
Cdd:smart00439   81 CNVLYKSDYPGLRPEGSIGEPDV-----------------F---------------FCESAYDPEKGSFKKLP 121
BAH pfam01426
BAH domain; This domain has been called BAH (Bromo adjacent homology) domain and has also been ...
 1295-1384 3.35e-16

BAH domain; This domain has been called BAH (Bromo adjacent homology) domain and has also been called ELM1 and BAM (Bromo adjacent motif) domain. The function of this domain is unknown but may be involved in protein-protein interaction.


Pssm-ID: 460207  Cd Length: 120  Bit Score: 76.19  E-value: 3.35e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85724844   1295 IIRIRDCVLLKANEDNELPYVAKVAHLWQNPEDGEMMMSLLWYYRPEHT--DQGRQRNdcPDEVYASRHRDHNSVACVED 1372
Cdd:pfam01426    2 TYSVGDFVLVEPDDADEPYYVARIEELFEDTKNGKKMVRVQWFYRPEETvhRAGKAFN--KDELFLSDEEDDVPLSAIIG 79

                           90
                   ....*....|..
gi 85724844   1373 KCYVLTFSEYCR 1384
Cdd:pfam01426   80 KCSVLHKSDLES 91
 
Name Accession Description Interval E-value
BAH_BAHCC1 cd04714
BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. ...
 1293-1446 2.30e-55

BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the remodeling of chromatin. It is assumed that in most or all of these instances the BAH domain mediates protein-protein interactions.


Pssm-ID: 240065  Cd Length: 121  Bit Score: 187.99  E-value: 2.30e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85724844 1293 GDIIRIRDCVLLKANEDNELPYVAKVAHLWQNPEdGEMMMSLLWYYRPEHTDQGRQRNDCPDEVYASRHRDHNSVACVED 1372
Cdd:cd04714    1 KEIIRVGDCVLFKSPGRPSLPYVARIESLWEDPE-GNMVVRVKWYYRPEETKGGRKPNHGEKELFASDHQDENSVQTIEH 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 85724844 1373 KCYVLTFSEYCRYRRRLRaaeedvedvsivprrpsiatapgfpvrtvpehTNPELVMFCRRAYEFRTRRLLKLP 1446
Cdd:cd04714   80 KCYVLTFAEYERLARVKK--------------------------------KPQDGVDFYYCAGTYNPDTGMLKC 121
BAH smart00439
Bromo adjacent homology domain;
1295-1446 1.64e-19

Bromo adjacent homology domain;


Pssm-ID: 214664 [Multi-domain]  Cd Length: 121  Bit Score: 85.81  E-value: 1.64e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85724844    1295 IIRIRDCVLLKANEDNELPYVAKVAHLWQNPEDGEMMMSLL-WYYRPEHTDQGRQRNDCPDEVYASRHRDHNSVACVEDK 1373
Cdd:smart00439    1 TISVGDFVLVEPDDADEPYYIGRIEEIFETKKNSESKMVRVrWFYRPEETVLEKAALFDKNEVFLSDEYDTVPLSDIIGK 80

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 85724844    1374 CYVLTFSEYCRYRRRLRAAEEDVedvsivprrpsiatapgFpvrtvpehtnpelvmFCRRAYEFRTRRLLKLP 1446
Cdd:smart00439   81 CNVLYKSDYPGLRPEGSIGEPDV-----------------F---------------FCESAYDPEKGSFKKLP 121
BAH pfam01426
BAH domain; This domain has been called BAH (Bromo adjacent homology) domain and has also been ...
 1295-1384 3.35e-16

BAH domain; This domain has been called BAH (Bromo adjacent homology) domain and has also been called ELM1 and BAM (Bromo adjacent motif) domain. The function of this domain is unknown but may be involved in protein-protein interaction.


Pssm-ID: 460207  Cd Length: 120  Bit Score: 76.19  E-value: 3.35e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85724844   1295 IIRIRDCVLLKANEDNELPYVAKVAHLWQNPEDGEMMMSLLWYYRPEHT--DQGRQRNdcPDEVYASRHRDHNSVACVED 1372
Cdd:pfam01426    2 TYSVGDFVLVEPDDADEPYYVARIEELFEDTKNGKKMVRVQWFYRPEETvhRAGKAFN--KDELFLSDEEDDVPLSAIIG 79

                           90
                   ....*....|..
gi 85724844   1373 KCYVLTFSEYCR 1384
Cdd:pfam01426   80 KCSVLHKSDLES 91
BAH cd04370
BAH, or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). ...
 1293-1396 4.18e-14

BAH, or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). BAH domains have first been described as domains found in the polybromo protein and Yeast Rsc1/Rsc2 (Remodeling of the Structure of Chromatin). They also occur in mammalian DNA methyltransferases and the MTA1 subunits of histone deacetylase complexes. A BAH domain is also found in Yeast Sir3p and in the origin receptor complex protein 1 (Orc1p), where it was found to interact with the N-terminal lobe of the silence information regulator 1 protein (Sir1p), confirming the initial hypothesis that BAH plays a role in protein-protein interactions.


Pssm-ID: 239835 [Multi-domain]  Cd Length: 123  Bit Score: 70.11  E-value: 4.18e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85724844 1293 GDIIRIRDCVLLKANE--DNELPYVAKVAHLWQNPEdGEMMMSLLWYYRPEHTDQGRQRNDCPDEVYASRHRDHNSVACV 1370
Cdd:cd04370    1 GITYEVGDSVYVEPDDsiKSDPPYIARIEELWEDTN-GSKQVKVRWFYRPEETPKGLSPFALRRELFLSDHLDEIPVESI 79

                         90       100
                 ....*....|....*....|....*.
gi 85724844 1371 EDKCYVLTFSEYCRYRRRLRAAEEDV 1396
Cdd:cd04370   80 IGKCKVLFVSEFEGLKQRPNKIDTDD 105
BAH_polybromo cd04717
BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human ...
 1293-1396 9.46e-14

BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional regulation. Saccharomyces cerevisiae RSC1 and RSC2 are part of the 15-subunit nucleosome remodeling RSC complex. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the remodeling of chromatin. It is assumed that in most or all of these instances the BAH domain mediates protein-protein interactions.


Pssm-ID: 240068  Cd Length: 121  Bit Score: 69.15  E-value: 9.46e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85724844 1293 GDIIRIRDCVLLKANEDNELPYVAKVAHLWQNpEDGEMMMSLLWYYRPEHTDQGRQRNDCPDEVYAS-RHRDHnSVACVE 1371
Cdd:cd04717    1 GLQYRVGDCVYVANPEDPSKPIIFRIERLWKD-EDGEKFFFGCWFYRPEETFHEPTRKFYKNEVFKSpLYETV-PVEEIV 78

                         90       100
                 ....*....|....*....|....*
gi 85724844 1372 DKCYVLTFSEYCRYRRRlRAAEEDV 1396
Cdd:cd04717   79 GKCAVMDVKDYIKGRPT-EISEEDV 102
BAH_plant_3 cd04713
BAH, or Bromo Adjacent Homology domain, plant-specific sub-family with unknown function. BAH ...
 1292-1436 4.93e-11

BAH, or Bromo Adjacent Homology domain, plant-specific sub-family with unknown function. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the remodeling of chromatin. It is assumed that in most or all of these instances the BAH domain mediates protein-protein interactions.


Pssm-ID: 240064  Cd Length: 146  Bit Score: 62.10  E-value: 4.93e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85724844 1292 EGDIIRIRDCVLLKAnEDNELPYVAKVAHLWQNpEDGEMMMSLLWYYRPEHTDQGRQRNDC---PDEVYASRHRDHNSVA 1368
Cdd:cd04713   17 DGNKYRLEDCVLLVP-EDDQKPYIAIIKDIYKQ-EEGSLKLEVQWLYRPEEIEKKKGGNWKaedPRELFYSFHRDEVPAE 94

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 85724844 1369 CVEDKCYvltfseycryrrrlraaeedvedVSIVPR---RPSIATAPGFPVRTVPEHTNPELVMFCRRAYE 1436
Cdd:cd04713   95 SVLHPCK-----------------------VAFVPKgkqIPLRKGHSGFIVRRVYDNVNKKLWKLTDQDYE 142
BAH_Dnmt1_I cd04760
BAH, or Bromo Adjacent Homology domain, first copy present in DNA (Cytosine-5) ...
 1293-1377 5.18e-06

BAH, or Bromo Adjacent Homology domain, first copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG dinucleotide, has profound effects on the genome. These effects include transcriptional repression via inhibition of transcription factor binding, the recruitment of methyl-binding proteins and their associated chromatin remodeling factors, X chromosome inactivation, imprinting, and the suppression of parasitic DNA sequences. DNA methylation is also essential for proper embryonic development and is an important player in both DNA repair and genome stability. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the remodeling of chromatin. It is assumed that in most or all of these instances the BAH domain mediates protein-protein interactions.


Pssm-ID: 240107  Cd Length: 124  Bit Score: 47.07  E-value: 5.18e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85724844 1293 GDIIRIRDCVLLKANEDNELPYVAKVAHLWQNpEDGEMMMSLLWYYRPehTDQGRQRNDCPDEVYASRHRDHNSVACVED 1372
Cdd:cd04760    1 GEELEAGDCVSVKPDDPTKPLYIARVTYMWKD-SIGGKMFHAHWFCRG--SDTVLGETSDPLELFLVDECEDMALSSIHG 77


                 ....*
gi 85724844 1373 KCYVL 1377
Cdd:cd04760   78 KVNVI 82
BAH_Orc1p_like cd04715
BAH, or Bromo Adjacent Homology domain, as present in the Schizosaccharomyces pombe homolog of ...
 1293-1384 4.84e-05

BAH, or Bromo Adjacent Homology domain, as present in the Schizosaccharomyces pombe homolog of Saccharomyces cerevisiae Orc1p and similar proteins. Orc1 is part of the Yeast Sir1-origin recognition complex, the Orc1p BAH doman functions in epigenetic silencing. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the remodeling of chromatin. It is assumed that in most or all of these instances the BAH domain mediates protein-protein interactions.


Pssm-ID: 240066  Cd Length: 159  Bit Score: 45.19  E-value: 4.84e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85724844 1293 GDIIRIRDCVLLKaNEDNElPYVAKVAHLWQNPED-GEMMMSLLWYYRP-----EHTDqgrQRNDCPDEVYASRHRDH-- 1364
Cdd:cd04715   27 GVEYRLYDDVYVH-NGDSE-PYIGKIIKIYETAIDsGKKKVKVIWFFRPseirmELKG---EPKRHINEVFLACGRGEgl 101

                         90       100
                 ....*....|....*....|...
gi 85724844 1365 ---NSVACVEDKCYVLTFSEYCR 1384
Cdd:cd04715  102 aniNLLESIIGKCNVVCISEDFR 124
BAH_plant_2 cd04718
BAH, or Bromo Adjacent Homology domain, plant-specific sub-family with unknown function. BAH ...
 1314-1399 1.85e-04

BAH, or Bromo Adjacent Homology domain, plant-specific sub-family with unknown function. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the remodeling of chromatin. It is assumed that in most or all of these instances the BAH domain mediates protein-protein interactions.


Pssm-ID: 240069  Cd Length: 148  Bit Score: 43.34  E-value: 1.85e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85724844 1314 YVAKVAHLWQnpEDGEMMMSLLWYYRPEHTDQGRQRNDCPDEVYASRHRDHNSVACVEDKCYVLTFSEYcryrrrlRAAE 1393
Cdd:cd04718   54 WLARIEKLWE--ENGTYWYAARWYTLPEETHMGRQPHNLRRELYLTNDFADIEMECILRHCSVKCPKEF-------RDAS 124


                 ....*.
gi 85724844 1394 EDVEDV 1399
Cdd:cd04718  125 NDGDDV 130
BAH_plant_1 cd04721
BAH, or Bromo Adjacent Homology domain, plant-specific sub-family with unknown function. BAH ...
 1293-1382 3.58e-04

BAH, or Bromo Adjacent Homology domain, plant-specific sub-family with unknown function. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the remodeling of chromatin. It is assumed that in most or all of these instances the BAH domain mediates protein-protein interactions.


Pssm-ID: 240072  Cd Length: 130  Bit Score: 42.05  E-value: 3.58e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85724844 1293 GDIIRIRDCVLLKANEDNElpYVAKVAHLWQNpEDGEMMMSLLWY-YRPEHTDQGRQRNDCPDEVYASRHRDHNSVACVE 1371
Cdd:cd04721    5 GVTISVHDFVYVLSEEEDR--YVAYIEDLYED-KKGSKMVKVRWFhTTDEVGAALSPDSVNPREIFLSPNLQVISVECID 81

                         90
                 ....*....|.
gi 85724844 1372 DKCYVLTFSEY 1382
Cdd:cd04721   82 GLATVLTREHY 92
BAH_plantDCM_I cd04716
BAH, or Bromo Adjacent Homology domain, first copy present in DNA (Cytosine-5) ...
 1293-1377 4.61e-04

BAH, or Bromo Adjacent Homology domain, first copy present in DNA (Cytosine-5)-methyltransferases (DCM) from plants. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG dinucleotide, has profound effects on the genome. These effects include transcriptional repression via inhibition of transcription factor binding, the recruitment of methyl-binding proteins and their associated chromatin remodeling factors, X chromosome inactivation, imprinting, and the suppression of parasitic DNA sequences. DNA methylation is also essential for proper embryonic development and is an important player in both DNA repair and genome stability. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the remodeling of chromatin. It is assumed that in most or all of these instances the BAH domain mediates protein-protein interactions.


Pssm-ID: 240067  Cd Length: 122  Bit Score: 41.66  E-value: 4.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85724844 1293 GDIIRIRDCVLLKANEDnELPYVAKVAHLWQNpEDGEMMMSLLWYYRPEHTDQGRQ-RNDCPDEVYASRHRDHNSVACVE 1371
Cdd:cd04716    1 GITYNLGDDAYVQGGEG-EEPFICKITEFFEG-TDGKTYFTAQWFYRAEDTVIERQaTNHDKKRVFYSEIKNDNPLDCLI 78


                 ....*.
gi 85724844 1372 DKCYVL 1377
Cdd:cd04716   79 SKVKIL 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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